CYP11A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* estrogen metabolic process (GO:0008210)9.61399973
2* C21-steroid hormone metabolic process (GO:0008207)9.14011552
3* hormone biosynthetic process (GO:0042446)9.08079529
4positive regulation of hormone biosynthetic process (GO:0046886)8.85468609
5* androgen metabolic process (GO:0008209)8.74935531
6cellular response to interferon-alpha (GO:0035457)8.45060646
7* cellular response to follicle-stimulating hormone stimulus (GO:0071372)8.35205985
8* cellular response to cadmium ion (GO:0071276)8.12022525
9regulation of gonadotropin secretion (GO:0032276)7.96884646
10* progesterone metabolic process (GO:0042448)7.36391819
11cellular response to growth hormone stimulus (GO:0071378)6.99063374
12adhesion of symbiont to host (GO:0044406)6.77082160
13* ketone biosynthetic process (GO:0042181)6.55383493
14positive regulation of hormone metabolic process (GO:0032352)6.50997917
15response to methylmercury (GO:0051597)6.49274099
16* response to follicle-stimulating hormone (GO:0032354)6.21096784
17cellular response to zinc ion (GO:0071294)6.09881735
18positive regulation of male gonad development (GO:2000020)6.04079945
19* cellular response to gonadotropin stimulus (GO:0071371)5.94921777
20* response to insecticide (GO:0017085)5.93220430
21regulation of male gonad development (GO:2000018)5.84514420
22response to leptin (GO:0044321)5.80752720
23negative regulation of macrophage differentiation (GO:0045650)5.75462399
24epoxygenase P450 pathway (GO:0019373)5.71143588
25* Leydig cell differentiation (GO:0033327)5.41302218
26* cellular response to antibiotic (GO:0071236)5.38163414
27positive regulation of steroid biosynthetic process (GO:0010893)5.26177805
28toxin metabolic process (GO:0009404)5.08684050
29sex determination (GO:0007530)4.84347476
30ovulation (GO:0030728)4.72333171
31cellular response to epinephrine stimulus (GO:0071872)4.71965734
32low-density lipoprotein particle clearance (GO:0034383)4.61060447
33regulation of female gonad development (GO:2000194)4.53185799
34phagocytosis, recognition (GO:0006910)4.52076075
35hemoglobin metabolic process (GO:0020027)4.44020974
36response to lead ion (GO:0010288)4.42903649
37gonadal mesoderm development (GO:0007506)4.35901292
38detection of molecule of bacterial origin (GO:0032490)4.35352296
39* response to gonadotropin (GO:0034698)4.31103244
40positive regulation of nitric-oxide synthase activity (GO:0051000)4.19211119
41sex differentiation (GO:0007548)4.16718878
42regulation of cholesterol biosynthetic process (GO:0045540)4.15069651
43response to interferon-alpha (GO:0035455)4.11637151
44glucosamine-containing compound catabolic process (GO:1901072)4.10747673
45seminiferous tubule development (GO:0072520)4.03383478
46renal system process involved in regulation of blood volume (GO:0001977)4.03131379
47NADP metabolic process (GO:0006739)4.01763824
48* cellular hormone metabolic process (GO:0034754)4.00104392
49* steroid biosynthetic process (GO:0006694)3.90189861
50uterus development (GO:0060065)3.85687489
51decidualization (GO:0046697)3.80316233
52purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.74141556
533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.74141556
54steroid catabolic process (GO:0006706)3.71624156
55intracellular lipid transport (GO:0032365)3.70378651
56response to epinephrine (GO:0071871)3.67678106
57cellular response to catecholamine stimulus (GO:0071870)3.67676741
58cellular response to monoamine stimulus (GO:0071868)3.67676741
59positive regulation of steroid metabolic process (GO:0045940)3.61660189
60positive regulation of triglyceride biosynthetic process (GO:0010867)3.55963970
61* response to corticosterone (GO:0051412)3.55072746
62* cellular response to toxic substance (GO:0097237)3.52551767
63positive regulation of triglyceride metabolic process (GO:0090208)3.51628077
64ovarian follicle development (GO:0001541)3.48305754
65NADPH regeneration (GO:0006740)3.47271819
66renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.45801994
67response to growth hormone (GO:0060416)3.45521611
68* cholesterol metabolic process (GO:0008203)3.45004578
69regulation of steroid hormone biosynthetic process (GO:0090030)3.43458139
70sulfation (GO:0051923)3.41275604
71amyloid precursor protein catabolic process (GO:0042987)3.40445010
72plasma lipoprotein particle clearance (GO:0034381)3.34231293
73* cytokine metabolic process (GO:0042107)3.33220673
74cellular response to dexamethasone stimulus (GO:0071549)3.33005974
75cholesterol biosynthetic process (GO:0006695)3.32635333
76regulation of cholesterol homeostasis (GO:2000188)3.30583200
77glyoxylate metabolic process (GO:0046487)3.28717557
78trivalent inorganic anion homeostasis (GO:0072506)3.25197181
79phosphate ion homeostasis (GO:0055062)3.25197181
80phenylpropanoid metabolic process (GO:0009698)3.20793861
81response to monoamine (GO:0071867)3.16786200
82response to catecholamine (GO:0071869)3.16786200
83regulation of cholesterol storage (GO:0010885)3.16129321
84regulation of steroid metabolic process (GO:0019218)3.11305077
85bile acid metabolic process (GO:0008206)3.11176064
86high-density lipoprotein particle remodeling (GO:0034375)3.10365832
87sterol catabolic process (GO:0016127)3.10099241
88cholesterol catabolic process (GO:0006707)3.10099241
89response to dexamethasone (GO:0071548)3.09305930
90endocrine hormone secretion (GO:0060986)3.07240880
91female gonad development (GO:0008585)3.05534262
92* hormone metabolic process (GO:0042445)3.05085227
93regulation of steroid biosynthetic process (GO:0050810)3.04337255
94* cellular ketone metabolic process (GO:0042180)3.04332559
95negative regulation of fatty acid transport (GO:2000192)3.04296290
96reverse cholesterol transport (GO:0043691)3.00761421
97* estrogen biosynthetic process (GO:0006703)22.1303785
98ovulation cycle process (GO:0022602)2.99208286
99male gonad development (GO:0008584)2.98830233
100regulation of cholesterol metabolic process (GO:0090181)2.96136109
101bile acid biosynthetic process (GO:0006699)2.92478035
102sterol biosynthetic process (GO:0016126)2.91173140
103circadian sleep/wake cycle process (GO:0022410)2.90118057
104negative regulation of complement activation (GO:0045916)2.85541761
105response to lipoprotein particle (GO:0055094)2.83911618
106cholesterol transport (GO:0030301)2.81434765
107sterol transport (GO:0015918)2.81434765
108gonad development (GO:0008406)2.79678570
109positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.79406214
110regulation of transforming growth factor beta2 production (GO:0032909)2.77736352
111negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76855500
112positive regulation of reproductive process (GO:2000243)2.76690153
113multicellular organismal aging (GO:0010259)2.62157251
114* sterol metabolic process (GO:0016125)2.60739712
115* benzene-containing compound metabolic process (GO:0042537)2.60490860
116adrenal gland development (GO:0030325)2.58790636
117positive regulation of monooxygenase activity (GO:0032770)2.57032878
118positive regulation of macrophage activation (GO:0043032)2.55903145
119male genitalia development (GO:0030539)2.55562981
120regulation of macrophage differentiation (GO:0045649)2.55092143
121detection of external biotic stimulus (GO:0098581)2.49394102
122tricarboxylic acid metabolic process (GO:0072350)2.48807566
123regulation of hormone biosynthetic process (GO:0046885)2.47682234
124maintenance of protein location in nucleus (GO:0051457)2.46143266
125cholesterol efflux (GO:0033344)2.41687747
126positive regulation of mast cell activation involved in immune response (GO:0033008)2.40997993
127positive regulation of mast cell degranulation (GO:0043306)2.40997993
128parturition (GO:0007567)2.40624923
129negative regulation of reproductive process (GO:2000242)2.38668614
130regulation of triglyceride biosynthetic process (GO:0010866)2.36917576
131glucocorticoid biosynthetic process (GO:0006704)17.1722359
132* androgen biosynthetic process (GO:0006702)16.5473318
133* C21-steroid hormone biosynthetic process (GO:0006700)13.6727618
134glucocorticoid metabolic process (GO:0008211)13.5373528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.48232237
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.00270746
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse5.00643227
4ESR1_15608294_ChIP-ChIP_MCF-7_Human4.90910187
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.77228502
6CLOCK_20551151_ChIP-Seq_293T_Human4.76881685
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.30773243
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.18446471
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.72699175
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.65047646
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.61279199
12RBPJ_22232070_ChIP-Seq_NCS_Mouse3.10100849
13ESR1_21235772_ChIP-Seq_MCF-7_Human3.07618631
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92632171
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.90780909
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90037782
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.76332362
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.60119243
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.50383256
20GBX2_23144817_ChIP-Seq_PC3_Human2.35931158
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.29900898
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.12736649
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04839749
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94808779
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94754407
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90793362
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88883944
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81580272
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.78917164
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.75970130
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66173841
32POU5F1_16518401_ChIP-PET_MESCs_Mouse1.65649981
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65508818
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.63325462
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.60706831
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59819839
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58592073
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55206464
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54270276
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50556739
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47857506
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41276572
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40810936
44LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40607430
45EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.38313456
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37104191
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.36566034
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35380072
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34383946
50EGR1_19032775_ChIP-ChIP_M12_Human1.33716190
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33205411
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32104301
53GF1_26923725_Chip-Seq_HPCs_Mouse1.30700821
54* KDM2B_26808549_Chip-Seq_DND41_Human1.29718380
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29682593
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28124001
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27647729
58AR_21572438_ChIP-Seq_LNCaP_Human1.25573918
59* ELK3_25401928_ChIP-Seq_HUVEC_Human1.25237279
60* LXR_22292898_ChIP-Seq_THP-1_Human1.21906345
61GATA4_25053715_ChIP-Seq_YYC3_Human1.20078828
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19229207
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19229207
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18626585
65SOX2_20726797_ChIP-Seq_SW620_Human1.18548954
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.16786383
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15605372
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15605372
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.14805672
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14620840
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14587276
72CDX2_20551321_ChIP-Seq_CACO-2_Human1.13085522
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.12648002
74TBX20_22080862_ChIP-Seq_HEART_Mouse1.12648002
75LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10252025
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10222500
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10007531
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09635658
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09283416
80ESET_19884257_ChIP-Seq_ESCs_Mouse1.08293580
81RUNX1_27514584_Chip-Seq_MCF-7_Human1.07440748
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06557358
83GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06418560
84RACK7_27058665_Chip-Seq_MCF-7_Human1.06291295
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.05612752
86TCF4_22108803_ChIP-Seq_LS180_Human1.05580425
87DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05330637
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04733074
89STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04254312
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03831672
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03773264
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.03525733
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.03331113
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02906935
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02906935
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02668870
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01570625
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00819312
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.00726075
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00628317
101EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98318211
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98187290
103RXR_22108803_ChIP-Seq_LS180_Human0.98031774
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97881693
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96580394
106* KDM2B_26808549_Chip-Seq_K562_Human0.96487470
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95922630
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95389055
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95308860
110* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94902213
111* KDM2B_26808549_Chip-Seq_JURKAT_Human0.94012864
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.92117896
113ISL1_27105846_Chip-Seq_CPCs_Mouse0.91664173
114TAL1_26923725_Chip-Seq_HPCs_Mouse0.91503678
115* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91183915
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90840328
117SMAD4_21799915_ChIP-Seq_A2780_Human0.90821899
118AR_25329375_ChIP-Seq_VCAP_Human0.90349334
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89352723
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89111321
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89041968
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86747789
123* GATA1_19941826_ChIP-Seq_K562_Human0.85975463
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85336267
125SMAD4_21741376_ChIP-Seq_EPCs_Human0.83745449
126* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83652266
127STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.83505681
128MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82846491
129* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82735327
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.82619741
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81981887
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81644822
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81577083
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81276077
135WT1_19549856_ChIP-ChIP_CCG9911_Human0.81094030
136PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80247297
137AHR_22903824_ChIP-Seq_MCF-7_Human0.80191780
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79576670
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79269840
140GATA2_21666600_ChIP-Seq_HMVEC_Human0.79236137
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79155781
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78858606
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78085739
144NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77875059
145CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77824378
146EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.77116232
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75505101
148ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75254660
149GATA6_25053715_ChIP-Seq_YYC3_Human0.75131117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000639_abnormal_adrenal_gland6.05365704
2MP0003941_abnormal_skin_development5.43948081
3MP0005647_abnormal_sex_gland5.13052921
4MP0003195_calcinosis4.49369532
5MP0009840_abnormal_foam_cell4.26266503
6MP0003011_delayed_dark_adaptation3.91356074
7MP0003122_maternal_imprinting3.85549550
8MP0008004_abnormal_stomach_pH3.74388124
9MP0001661_extended_life_span3.71933431
10MP0001919_abnormal_reproductive_system3.55052010
11MP0008438_abnormal_cutaneous_collagen3.33974282
12MP0008995_early_reproductive_senescence3.17504291
13MP0003315_abnormal_perineum_morphology3.11208720
14MP0005389_reproductive_system_phenotype3.10298806
15* MP0002909_abnormal_adrenal_gland2.91244236
16MP0005083_abnormal_biliary_tract2.88047028
17MP0004883_abnormal_blood_vessel2.85132876
18MP0000647_abnormal_sebaceous_gland2.58991052
19MP0005187_abnormal_penis_morphology2.49524594
20MP0010368_abnormal_lymphatic_system2.39742769
21MP0003786_premature_aging2.25883522
22MP0010329_abnormal_lipoprotein_level2.21519570
23MP0000230_abnormal_systemic_arterial2.19915136
24MP0009384_cardiac_valve_regurgitation2.16272752
25MP0009780_abnormal_chondrocyte_physiolo2.15685555
26MP0009278_abnormal_bone_marrow2.14731715
27MP0003121_genomic_imprinting2.09044765
28MP0005379_endocrine/exocrine_gland_phen2.02183584
29MP0000013_abnormal_adipose_tissue1.94622384
30* MP0001765_abnormal_ion_homeostasis1.90758522
31MP0006054_spinal_hemorrhage1.86211252
32MP0002160_abnormal_reproductive_system1.85498076
33MP0005164_abnormal_response_to1.78303823
34MP0001119_abnormal_female_reproductive1.77864908
35MP0004084_abnormal_cardiac_muscle1.71109012
36MP0002254_reproductive_system_inflammat1.68285084
37MP0005503_abnormal_tendon_morphology1.67753800
38MP0000538_abnormal_urinary_bladder1.67481506
39MP0003329_amyloid_beta_deposits1.67368801
40MP0003638_abnormal_response/metabolism_1.60989944
41MP0003279_aneurysm1.54572171
42* MP0003953_abnormal_hormone_level1.51226653
43MP0003300_gastrointestinal_ulcer1.49958969
44MP0001881_abnormal_mammary_gland1.49659124
45MP0000631_abnormal_neuroendocrine_gland1.48735801
46MP0000343_altered_response_to1.45942985
47MP0005623_abnormal_meninges_morphology1.45114091
48MP0006276_abnormal_autonomic_nervous1.39614632
49MP0002938_white_spotting1.36334428
50MP0004019_abnormal_vitamin_homeostasis1.35847148
51* MP0005636_abnormal_mineral_homeostasis1.34957673
52MP0001984_abnormal_olfaction1.34953905
53MP0005248_abnormal_Harderian_gland1.33920398
54MP0009053_abnormal_anal_canal1.30302270
55MP0008875_abnormal_xenobiotic_pharmacok1.30174580
56MP0001879_abnormal_lymphatic_vessel1.28899735
57MP0003566_abnormal_cell_adhesion1.25413160
58MP0009672_abnormal_birth_weight1.24653757
59MP0003567_abnormal_fetal_cardiomyocyte1.23955875
60MP0004272_abnormal_basement_membrane1.22997412
61MP0004036_abnormal_muscle_relaxation1.22069350
62MP0003699_abnormal_female_reproductive1.21217352
63MP0005319_abnormal_enzyme/_coenzyme1.20112909
64MP0003191_abnormal_cellular_cholesterol1.11291250
65MP0001851_eye_inflammation1.11093960
66MP0000003_abnormal_adipose_tissue1.10353048
67MP0002168_other_aberrant_phenotype1.10173453
68MP0009697_abnormal_copulation1.08369373
69MP0001958_emphysema1.07790399
70MP0008775_abnormal_heart_ventricle1.07172942
71MP0003705_abnormal_hypodermis_morpholog1.05669013
72MP0004858_abnormal_nervous_system1.02370086
73MP0003950_abnormal_plasma_membrane1.01434069
74MP0002896_abnormal_bone_mineralization1.00291490
75MP0003959_abnormal_lean_body1.00218571
76MP0002837_dystrophic_cardiac_calcinosis0.98539499
77MP0001542_abnormal_bone_strength0.96491587
78MP0002998_abnormal_bone_remodeling0.95374570
79MP0002877_abnormal_melanocyte_morpholog0.93868238
80MP0000249_abnormal_blood_vessel0.93648368
81MP0005023_abnormal_wound_healing0.93472775
82MP0000751_myopathy0.91287655
83MP0010386_abnormal_urinary_bladder0.90771599
84MP0000767_abnormal_smooth_muscle0.90120291
85MP0003936_abnormal_reproductive_system0.89765446
86MP0005584_abnormal_enzyme/coenzyme_acti0.89439538
87MP0003091_abnormal_cell_migration0.88352733
88MP0003123_paternal_imprinting0.88146154
89MP0003115_abnormal_respiratory_system0.88052942
90MP0009643_abnormal_urine_homeostasis0.87253673
91* MP0000653_abnormal_sex_gland0.87250908
92MP0010630_abnormal_cardiac_muscle0.86202461
93MP0001915_intracranial_hemorrhage0.86112979
94MP0000604_amyloidosis0.85104486
95MP0005253_abnormal_eye_physiology0.84410182
96MP0005167_abnormal_blood-brain_barrier0.82858965
97MP0005275_abnormal_skin_tensile0.82435400
98MP0004085_abnormal_heartbeat0.80839247
99MP0003385_abnormal_body_wall0.80077090
100MP0004147_increased_porphyrin_level0.78837447
101MP0002557_abnormal_social/conspecific_i0.77693813
102MP0006138_congestive_heart_failure0.76867286
103MP0000627_abnormal_mammary_gland0.76622514
104MP0002127_abnormal_cardiovascular_syste0.75302415
105MP0005508_abnormal_skeleton_morphology0.74315482
106MP0002115_abnormal_skeleton_extremities0.72880866
107MP0000462_abnormal_digestive_system0.72328822
108MP0009703_decreased_birth_body0.71600612
109MP0005058_abnormal_lysosome_morphology0.71594071
110* MP0001929_abnormal_gametogenesis0.70829121
111* MP0001145_abnormal_male_reproductive0.70343388
112MP0004145_abnormal_muscle_electrophysio0.68954250
113MP0001340_abnormal_eyelid_morphology0.68539335
114MP0005334_abnormal_fat_pad0.68392941
115MP0009250_abnormal_appendicular_skeleto0.68360510
116MP0002295_abnormal_pulmonary_circulatio0.67670121
117MP0004134_abnormal_chest_morphology0.66764163
118* MP0009642_abnormal_blood_homeostasis0.66665755
119MP0005365_abnormal_bile_salt0.66035348
120MP0001756_abnormal_urination0.64649030
121* MP0002210_abnormal_sex_determination0.63698155
122MP0002128_abnormal_blood_circulation0.63680972
123MP0004264_abnormal_extraembryonic_tissu0.63527714
124MP0003942_abnormal_urinary_system0.63046476
125MP0001614_abnormal_blood_vessel0.62947529
126MP0002009_preneoplasia0.62630082
127MP0003690_abnormal_glial_cell0.61979677
128MP0002876_abnormal_thyroid_physiology0.61864702
129MP0003186_abnormal_redox_activity0.61750682
130MP0008469_abnormal_protein_level0.61249453
131MP0004510_myositis0.61236097
132MP0000266_abnormal_heart_morphology0.60937773
133MP0004484_altered_response_of0.60383510
134MP0002135_abnormal_kidney_morphology0.60202573
135MP0003795_abnormal_bone_structure0.58484081
136MP0005464_abnormal_platelet_physiology0.57785794
137MP0000681_abnormal_thyroid_gland0.57747082
138MP0003718_maternal_effect0.57535660
139MP0000609_abnormal_liver_physiology0.55826738
140* MP0002118_abnormal_lipid_homeostasis0.54910418
141MP0000750_abnormal_muscle_regeneration0.53278388
142MP0005391_vision/eye_phenotype0.51757773
143MP0002697_abnormal_eye_size0.46597717
144MP0003698_abnormal_male_reproductive0.42409065
145MP0005452_abnormal_adipose_tissue0.40387475
146MP0004782_abnormal_surfactant_physiolog0.39225593
147MP0003890_abnormal_embryonic-extraembry0.38601986
148MP0005375_adipose_tissue_phenotype0.38474016
149MP0005330_cardiomyopathy0.38406481
150MP0000598_abnormal_liver_morphology0.38238625
151MP0005448_abnormal_energy_balance0.36865037
152MP0003935_abnormal_craniofacial_develop0.35543771
153MP0005595_abnormal_vascular_smooth0.35376872
154MP0005076_abnormal_cell_differentiation0.32922706

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)6.81895095
2* Renal salt wasting (HP:0000127)6.73794216
3Hypokalemic alkalosis (HP:0001949)6.22813011
4Gonadal dysgenesis (HP:0000133)6.06536279
5Menstrual irregularities (HP:0000858)5.63115961
6Testicular neoplasm (HP:0010788)5.56416803
7Premature ovarian failure (HP:0008209)5.41305713
8Hypoplasia of the uterus (HP:0000013)5.33670029
9Abnormality of renin-angiotensin system (HP:0000847)4.84722552
10Multiple enchondromatosis (HP:0005701)4.58497925
11* Hyperpituitarism (HP:0010514)4.51599677
12Lymphangioma (HP:0100764)4.39859352
13Azoospermia (HP:0000027)4.33582675
14Aplasia/hypoplasia of the uterus (HP:0008684)4.21669441
15Macroorchidism (HP:0000053)4.15654062
16Large earlobe (HP:0009748)4.15065423
17Gynecomastia (HP:0000771)4.01890569
18Abnormality of the clitoris (HP:0000056)3.97917136
19Bifid tongue (HP:0010297)3.95842338
20Bilateral microphthalmos (HP:0007633)3.90940409
21Accelerated skeletal maturation (HP:0005616)3.90636202
22Neonatal onset (HP:0003623)3.88481389
23Absent eyebrow (HP:0002223)3.83856804
24Bicornuate uterus (HP:0000813)3.78416411
25Choanal stenosis (HP:0000452)3.77388960
26Morphological abnormality of the middle ear (HP:0008609)3.76030456
27Increased circulating renin level (HP:0000848)3.69149550
28Myelomeningocele (HP:0002475)3.61655193
29Female pseudohermaphroditism (HP:0010458)3.51686649
30Orthostatic hypotension (HP:0001278)3.41811490
31Secondary amenorrhea (HP:0000869)3.39835208
32* Hyperaldosteronism (HP:0000859)3.36999233
33Hypospadias (HP:0000047)3.27659933
34Cupped ear (HP:0000378)3.27652664
35Hydroxyprolinuria (HP:0003080)3.24414793
36Abnormality of proline metabolism (HP:0010907)3.24414793
37Tracheal stenosis (HP:0002777)3.20477715
38Precocious puberty (HP:0000826)3.15118780
39Absent frontal sinuses (HP:0002688)3.08864399
40Anomalous pulmonary venous return (HP:0010772)3.06002873
41Absent eyelashes (HP:0000561)3.05008077
42Alkalosis (HP:0001948)2.99980329
43Abnormal spermatogenesis (HP:0008669)2.99083283
44Abnormality of the parathyroid morphology (HP:0011766)2.87478603
45Pulmonary fibrosis (HP:0002206)2.84480624
46Abnormal cartilage morphology (HP:0002763)2.79086754
47Male pseudohermaphroditism (HP:0000037)2.76718236
48Partial agenesis of the corpus callosum (HP:0001338)2.72409575
49Midline defect of the nose (HP:0004122)2.69570046
50Spondylolisthesis (HP:0003302)2.68110152
51Relative macrocephaly (HP:0004482)2.66821873
52Infertility (HP:0000789)2.66370622
53Neoplasm of the adrenal gland (HP:0100631)2.62452935
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.62193300
55Complement deficiency (HP:0004431)2.61319816
56Abnormality of the pulmonary veins (HP:0011718)2.61022850
57Abnormal hemoglobin (HP:0011902)2.59978255
58Abnormality of the pubic bones (HP:0003172)2.56608035
59Abnormal lung lobation (HP:0002101)2.54483853
60Cutaneous finger syndactyly (HP:0010554)2.53330621
61Abnormal pancreas size (HP:0012094)2.49851071
62Exostoses (HP:0100777)2.49320736
63Visceral angiomatosis (HP:0100761)2.44396597
64Osteolytic defects of the hand bones (HP:0009699)2.44132800
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.44132800
66Scrotal hypoplasia (HP:0000046)2.42952414
67Purpura (HP:0000979)2.41445254
68Nausea (HP:0002018)2.38270618
69Abnormality of potassium homeostasis (HP:0011042)2.32185925
70Cerebral aneurysm (HP:0004944)2.27978105
71Hemangiomatosis (HP:0007461)2.27032091
72Anophthalmia (HP:0000528)2.26795549
73Neurofibrillary tangles (HP:0002185)2.26664202
74Premature rupture of membranes (HP:0001788)2.26440418
75Rectal prolapse (HP:0002035)2.23153669
76Broad metatarsal (HP:0001783)2.23133537
77Ovarian neoplasm (HP:0100615)2.22930705
78Ankle contracture (HP:0006466)2.22874423
79Xanthomatosis (HP:0000991)2.22242712
80Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.19952125
81Urinary glycosaminoglycan excretion (HP:0003541)2.19898149
82Mucopolysacchariduria (HP:0008155)2.19898149
83Cutaneous syndactyly (HP:0012725)2.18719162
84Ureteral duplication (HP:0000073)2.18090904
85Ulnar bowing (HP:0003031)2.17986256
86Broad alveolar ridges (HP:0000187)2.17679758
87Hyperkalemia (HP:0002153)2.16588059
88Absent hair (HP:0002298)2.16430631
89Hypokalemia (HP:0002900)2.15185838
90Skull defect (HP:0001362)2.15006615
91Vertebral clefting (HP:0008428)2.14557072
92Clitoromegaly (HP:0000057)2.12548296
93Epidermoid cyst (HP:0200040)2.11997505
94Abnormality of the axillary hair (HP:0100134)2.11945331
95Abnormality of secondary sexual hair (HP:0009888)2.11945331
96* Adrenal overactivity (HP:0002717)2.09380621
97Abnormality of the alveolar ridges (HP:0006477)2.09070244
98Abnormality of liposaccharide metabolism (HP:0010968)2.08920173
99Abnormality of glycosphingolipid metabolism (HP:0004343)2.08920173
100Abnormality of glycolipid metabolism (HP:0010969)2.08920173
101Aplasia involving bones of the upper limbs (HP:0009823)2.07307236
102Aplasia of the phalanges of the hand (HP:0009802)2.07307236
103Aplasia involving bones of the extremities (HP:0009825)2.07307236
104Ectopic anus (HP:0004397)2.06889383
105Delayed closure of the anterior fontanelle (HP:0001476)2.06031481
106Bronchomalacia (HP:0002780)2.06022055
107Skin nodule (HP:0200036)2.05351045
108Facial cleft (HP:0002006)2.04648777
109Aplasia of the musculature (HP:0100854)2.03797502
110Abnormality of the lacrimal duct (HP:0011481)2.03765299
111Hypoplastic nipples (HP:0002557)2.03705956
112Growth hormone excess (HP:0000845)2.01350179
113Mitral stenosis (HP:0001718)2.00231450
114Gonadotropin excess (HP:0000837)13.8381644
115Enlarged penis (HP:0000040)12.2563933
116Primary adrenal insufficiency (HP:0008207)1.99268490
117Increased number of teeth (HP:0011069)1.97290941
118Abnormality of carpal bone ossification (HP:0006257)1.97141648
119Abnormality of polysaccharide metabolism (HP:0011012)1.95041719
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95041719
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95041719
122Aortic aneurysm (HP:0004942)1.94815145
123Short humerus (HP:0005792)1.94113744
124Vaginal atresia (HP:0000148)1.92621836
125Recurrent gram-negative bacterial infections (HP:0005420)1.92023505
126Cerebral palsy (HP:0100021)1.91407575
127Wormian bones (HP:0002645)1.89973512
128Wide intermamillary distance (HP:0006610)1.89908906
129Abnormality of the nasolacrimal system (HP:0000614)1.88875288
130Neonatal hypoglycemia (HP:0001998)1.88812872
131Lower limb asymmetry (HP:0100559)1.88584941
132Short middle phalanx of the 5th finger (HP:0004220)1.87955981
133Abnormality of complement system (HP:0005339)1.86713935
134Short hallux (HP:0010109)1.86440527
135Breech presentation (HP:0001623)1.86316109
136Short clavicles (HP:0000894)1.86197120
137Abnormality of the aortic arch (HP:0012303)1.84079761
138Menorrhagia (HP:0000132)1.83731805
139Episodic fever (HP:0001954)1.83728684
140Genital tract atresia (HP:0001827)1.82507678
141Limited hip movement (HP:0008800)1.81892758
142Male infertility (HP:0003251)1.81889064
143Arachnodactyly (HP:0001166)1.80074480
144Buphthalmos (HP:0000557)1.79366545
145Aplasia/hypoplasia of the humerus (HP:0006507)1.79040415
146Patent foramen ovale (HP:0001655)1.74092070
147Protrusio acetabuli (HP:0003179)1.72454874
148Diastasis recti (HP:0001540)1.72263423
149Systemic lupus erythematosus (HP:0002725)1.69952431
150Aplasia/Hypoplasia of the hallux (HP:0008362)1.69866076
151Rhizomelia (HP:0008905)1.67930433
152Long clavicles (HP:0000890)1.67676217
153Bifid scrotum (HP:0000048)1.64870762
154Cavernous hemangioma (HP:0001048)1.64733453
155Aortic dissection (HP:0002647)1.64387973
156Selective tooth agenesis (HP:0001592)1.64284835
157Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.61697635
158Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60369025
159Abnormality of the frontal sinuses (HP:0002687)1.55847728
160Acne (HP:0001061)1.53456384
161Multifactorial inheritance (HP:0001426)1.52562278
162Petechiae (HP:0000967)1.50412257
163Decreased testicular size (HP:0008734)1.49524519
164Narrow palate (HP:0000189)1.47925407
165Primary amenorrhea (HP:0000786)1.47161726
166Cervical subluxation (HP:0003308)1.46806857
167Increased mean platelet volume (HP:0011877)1.46363488
168Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.45046113
169Oligomenorrhea (HP:0000876)1.41590455
170Striae distensae (HP:0001065)1.38569820
171Blue sclerae (HP:0000592)1.38473649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.97084410
2AKT34.67318383
3PIK3CG4.42797943
4ERN13.52534950
5PKN22.86267966
6CDK72.86258340
7TGFBR22.74959797
8PRPF4B2.73086283
9TAOK32.47751705
10MELK2.31146025
11LRRK22.27668666
12DDR22.07487505
13PTK62.06835391
14AKT21.98631727
15MAP3K51.90469170
16EEF2K1.82454811
17PDGFRA1.82267333
18GRK51.78721229
19JAK11.77873288
20PDK21.75219495
21FER1.73452565
22FGFR21.72342746
23TESK11.65828501
24TAOK21.64319140
25MYLK1.63415932
26EPHA41.59785699
27PAK11.45954637
28EPHB21.37716058
29LIMK11.37127408
30MAPK121.32473325
31TTN1.32260803
32ILK1.28052565
33PAK41.27941113
34CDK61.27839891
35KSR21.24222744
36KIT1.23950522
37RIPK41.18468315
38TRPM71.15807178
39ERBB41.13504952
40FGFR41.12688476
41MAP3K121.11319763
42JAK21.08304827
43CAMK1G1.07366500
44MST41.06790617
45PAK31.05268414
46PINK11.04203598
47STK31.03116184
48MAPK31.00511799
49FGFR10.99512187
50NTRK10.99349650
51NLK0.97393764
52RIPK10.97281780
53ERBB30.96669470
54LATS10.92036453
55PIM10.90811284
56INSRR0.88555896
57MAPK70.88103893
58JAK30.87842004
59PTK2B0.86858637
60MAP2K20.85647288
61PRKAA20.85633738
62CSNK1A1L0.83879980
63PDPK10.80289076
64TYK20.79019216
65SGK10.78971896
66ICK0.78451856
67SIK10.77942466
68TNK20.76695880
69TNIK0.74477870
70CSNK1G10.74323813
71CSNK1G20.71154140
72PRKCZ0.69267030
73MAPKAPK50.67675471
74KDR0.67417355
75BRD40.66484813
76MAP2K10.66448721
77RET0.65630348
78TYRO30.65063784
79PAK20.64914806
80MTOR0.64875266
81WNK30.64637460
82DMPK0.63780857
83NEK90.63295391
84MAP3K20.62191967
85PTK20.60280570
86CDK120.59256222
87IGF1R0.59150708
88TAOK10.58707000
89MATK0.57077442
90PRKCH0.56123048
91YES10.55889386
92PDGFRB0.55594513
93PDK10.55018115
94CSNK1G30.53925907
95TTK0.52314559
96MAP3K70.50929407
97SCYL20.50757502
98CAMK40.50412024
99EIF2AK30.50267132
100CAMK1D0.49905421
101MAPK10.49558296
102SRC0.49419138
103FGFR30.48908120
104ZAP700.48620031
105FLT30.48528151
106PRKD10.46983822
107BMX0.45826263
108HIPK20.45696352
109DYRK1B0.45654564
110PBK0.44699848
111ACVR1B0.44472557
112STK100.44084627
113PRKACG0.43994927
114PRKACA0.43915747
115ROCK20.43520651
116TIE10.42957716
117BCKDK0.42844281
118LMTK20.42282056
119ITK0.42183040
120WNK10.42088636
121PRKACB0.41555907
122UHMK10.40607613
123ALK0.39757751
124LATS20.39058088
125TBK10.38755358
126FRK0.38073678
127TGFBR10.37231516
128EGFR0.35552988
129ERBB20.34814595
130MAPK90.33612177
131CDC42BPA0.33344820
132RPS6KA30.32929488
133GSK3A0.32385350
134BMPR1B0.32382473
135PLK20.31713166
136ROCK10.31486024
137MST1R0.30068915
138MAP3K40.29154250
139SGK30.28555426
140CSNK1A10.28253742
141PRKD30.27845866
142ADRBK10.27440179
143SGK20.25350050
144MAP3K80.23765097
145TSSK60.22244006
146MAP3K60.21307675
147NTRK30.20466952
148NEK60.20143144
149CAMK10.19578687
150SGK4940.19276228
151SGK2230.19276228
152STK380.19114016

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ovarian steroidogenesis_Homo sapiens_hsa049138.44068621
2* Steroid hormone biosynthesis_Homo sapiens_hsa001407.70367602
3* Aldosterone synthesis and secretion_Homo sapiens_hsa049254.71150640
4Vitamin B6 metabolism_Homo sapiens_hsa007502.68787564
5Fatty acid biosynthesis_Homo sapiens_hsa000612.51420981
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29256385
7Fatty acid metabolism_Homo sapiens_hsa012122.28463759
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19009705
9Fatty acid degradation_Homo sapiens_hsa000712.11593916
10Steroid biosynthesis_Homo sapiens_hsa001002.11329639
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09604143
12Sulfur metabolism_Homo sapiens_hsa009201.99915752
13Asthma_Homo sapiens_hsa053101.66835407
14Renin-angiotensin system_Homo sapiens_hsa046141.66422578
15Chemical carcinogenesis_Homo sapiens_hsa052041.61991855
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54179587
17Selenocompound metabolism_Homo sapiens_hsa004501.54108467
18PPAR signaling pathway_Homo sapiens_hsa033201.49678812
19Vitamin digestion and absorption_Homo sapiens_hsa049771.39701932
20Tyrosine metabolism_Homo sapiens_hsa003501.39374796
21Fat digestion and absorption_Homo sapiens_hsa049751.25145699
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.15440859
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06891392
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01504604
25ECM-receptor interaction_Homo sapiens_hsa045121.00651563
26Prolactin signaling pathway_Homo sapiens_hsa049170.99853014
27Tryptophan metabolism_Homo sapiens_hsa003800.99820070
28Pyruvate metabolism_Homo sapiens_hsa006200.99388441
29TGF-beta signaling pathway_Homo sapiens_hsa043500.98192495
30Glutathione metabolism_Homo sapiens_hsa004800.85897924
31Lysosome_Homo sapiens_hsa041420.80978352
32Complement and coagulation cascades_Homo sapiens_hsa046100.77764454
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75039336
34Arachidonic acid metabolism_Homo sapiens_hsa005900.74959513
35Carbon metabolism_Homo sapiens_hsa012000.74651957
36Fatty acid elongation_Homo sapiens_hsa000620.73809450
37Focal adhesion_Homo sapiens_hsa045100.70048222
38Bile secretion_Homo sapiens_hsa049760.70029238
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68024329
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64960540
41Sphingolipid metabolism_Homo sapiens_hsa006000.62496846
42Proteoglycans in cancer_Homo sapiens_hsa052050.60689283
43Histidine metabolism_Homo sapiens_hsa003400.59222564
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.59099801
45Estrogen signaling pathway_Homo sapiens_hsa049150.57898818
46GnRH signaling pathway_Homo sapiens_hsa049120.56459715
47Propanoate metabolism_Homo sapiens_hsa006400.55750715
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53889512
49Lysine degradation_Homo sapiens_hsa003100.53531621
50cAMP signaling pathway_Homo sapiens_hsa040240.53470208
51ABC transporters_Homo sapiens_hsa020100.53338233
52Prostate cancer_Homo sapiens_hsa052150.53296052
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.53085252
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.49146992
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48932571
56Staphylococcus aureus infection_Homo sapiens_hsa051500.48871360
57Peroxisome_Homo sapiens_hsa041460.48290665
58Retinol metabolism_Homo sapiens_hsa008300.46924244
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46911891
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46128778
61Osteoclast differentiation_Homo sapiens_hsa043800.45504401
62Amoebiasis_Homo sapiens_hsa051460.44392010
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44111389
64Thyroid hormone synthesis_Homo sapiens_hsa049180.44083691
65Renin secretion_Homo sapiens_hsa049240.43693298
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43126159
67Butanoate metabolism_Homo sapiens_hsa006500.41315835
68Phagosome_Homo sapiens_hsa041450.41002510
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.40735502
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40175129
71Platelet activation_Homo sapiens_hsa046110.38694087
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38484269
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38047867
74* Metabolic pathways_Homo sapiens_hsa011000.37955248
75Dilated cardiomyopathy_Homo sapiens_hsa054140.37434543
76Chronic myeloid leukemia_Homo sapiens_hsa052200.37434146
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37320497
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36675864
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35285522
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35225699
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34314238
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34121191
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33641304
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32708136
85Insulin resistance_Homo sapiens_hsa049310.31996208
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31093162
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29531388
88Toxoplasmosis_Homo sapiens_hsa051450.27435965
89Pancreatic cancer_Homo sapiens_hsa052120.25727361
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24982305
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24764796
92Hepatitis C_Homo sapiens_hsa051600.24518565
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24098775
94Small cell lung cancer_Homo sapiens_hsa052220.22998129
95Vibrio cholerae infection_Homo sapiens_hsa051100.22863082
96Arginine and proline metabolism_Homo sapiens_hsa003300.22785581
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22689279
98Nitrogen metabolism_Homo sapiens_hsa009100.22634098
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22486672
100Adherens junction_Homo sapiens_hsa045200.22421358
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22366645
102Glycerolipid metabolism_Homo sapiens_hsa005610.22234277
103Calcium signaling pathway_Homo sapiens_hsa040200.22179767
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22109598
105N-Glycan biosynthesis_Homo sapiens_hsa005100.20887061
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20735476
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20391285
108Renal cell carcinoma_Homo sapiens_hsa052110.19820908
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.19759235
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19758164
111Prion diseases_Homo sapiens_hsa050200.19648505
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19345788
113Ras signaling pathway_Homo sapiens_hsa040140.18768119
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18696476
115Caffeine metabolism_Homo sapiens_hsa002320.18025366
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17353188
117Tight junction_Homo sapiens_hsa045300.16630822
118Protein digestion and absorption_Homo sapiens_hsa049740.16478747
119Circadian rhythm_Homo sapiens_hsa047100.16232649
120Cocaine addiction_Homo sapiens_hsa050300.16172804
121Wnt signaling pathway_Homo sapiens_hsa043100.15986940
122VEGF signaling pathway_Homo sapiens_hsa043700.15843790
123Mineral absorption_Homo sapiens_hsa049780.15005479
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14876643
125beta-Alanine metabolism_Homo sapiens_hsa004100.14869376
126Biosynthesis of amino acids_Homo sapiens_hsa012300.14692654
127Antigen processing and presentation_Homo sapiens_hsa046120.14679077
128Apoptosis_Homo sapiens_hsa042100.14332684
129Tuberculosis_Homo sapiens_hsa051520.14265211
130Rap1 signaling pathway_Homo sapiens_hsa040150.13797507
131Hedgehog signaling pathway_Homo sapiens_hsa043400.12821769
132Folate biosynthesis_Homo sapiens_hsa007900.12588894
133Gastric acid secretion_Homo sapiens_hsa049710.08142135
134Inositol phosphate metabolism_Homo sapiens_hsa005620.07442187
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.06958856
136FoxO signaling pathway_Homo sapiens_hsa040680.04030521
137Dorso-ventral axis formation_Homo sapiens_hsa043200.04004397
138Endometrial cancer_Homo sapiens_hsa052130.03764430
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.03726421
140AMPK signaling pathway_Homo sapiens_hsa041520.03254539

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