CYP17A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* C21-steroid hormone metabolic process (GO:0008207)9.56762447
2* progesterone metabolic process (GO:0042448)9.09170406
3* cellular response to antibiotic (GO:0071236)9.02671169
4* cellular response to gonadotropin stimulus (GO:0071371)8.44238093
5cellular response to epinephrine stimulus (GO:0071872)8.09494263
6* hormone biosynthetic process (GO:0042446)7.95339259
7cellular response to cadmium ion (GO:0071276)7.76575711
8ketone biosynthetic process (GO:0042181)7.51143880
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.44176531
10L-phenylalanine catabolic process (GO:0006559)7.44176531
11response to epinephrine (GO:0071871)7.18355757
12L-phenylalanine metabolic process (GO:0006558)7.08167522
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.08167522
14cellular response to interferon-alpha (GO:0035457)6.78682219
15toxin metabolic process (GO:0009404)6.76332898
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.68559879
17* cellular response to toxic substance (GO:0097237)6.60548909
18cellular response to growth hormone stimulus (GO:0071378)6.56022195
19response to corticosterone (GO:0051412)6.50213560
20aromatic amino acid family catabolic process (GO:0009074)6.40487347
21alpha-linolenic acid metabolic process (GO:0036109)6.15999448
22high-density lipoprotein particle remodeling (GO:0034375)6.10039602
23mating behavior (GO:0007617)5.98275750
24* androgen metabolic process (GO:0008209)5.90819102
25* response to gonadotropin (GO:0034698)5.89469174
26* response to insecticide (GO:0017085)5.71818011
27urea metabolic process (GO:0019627)5.71749370
28urea cycle (GO:0000050)5.71749370
29positive regulation of male gonad development (GO:2000020)5.66607374
30estrogen metabolic process (GO:0008210)5.47222962
31tryptophan catabolic process (GO:0006569)5.44665870
32indole-containing compound catabolic process (GO:0042436)5.44665870
33indolalkylamine catabolic process (GO:0046218)5.44665870
34bile acid biosynthetic process (GO:0006699)5.43511821
35negative regulation of fibrinolysis (GO:0051918)5.43181628
36kynurenine metabolic process (GO:0070189)5.37625404
37glyoxylate metabolic process (GO:0046487)5.34123407
38reverse cholesterol transport (GO:0043691)5.31966477
39regulation of cholesterol esterification (GO:0010872)5.29801468
40gonadal mesoderm development (GO:0007506)5.26144329
41response to mineralocorticoid (GO:0051385)5.23963694
42nitrogen cycle metabolic process (GO:0071941)5.23380273
43peptidyl-glutamic acid carboxylation (GO:0017187)5.23041805
44protein carboxylation (GO:0018214)5.23041805
45tryptophan metabolic process (GO:0006568)5.18750752
46sulfur amino acid catabolic process (GO:0000098)5.18519901
47low-density lipoprotein particle clearance (GO:0034383)5.14483939
48regulation of fibrinolysis (GO:0051917)5.13903314
49intracellular lipid transport (GO:0032365)5.08103385
50response to lead ion (GO:0010288)5.06064823
51response to phenylpropanoid (GO:0080184)5.05203808
52protein-lipid complex remodeling (GO:0034368)5.04865646
53macromolecular complex remodeling (GO:0034367)5.04865646
54plasma lipoprotein particle remodeling (GO:0034369)5.04865646
55serine family amino acid catabolic process (GO:0009071)4.99211162
56phospholipid efflux (GO:0033700)4.97608364
57response to leptin (GO:0044321)4.96981252
58* Leydig cell differentiation (GO:0033327)4.93660600
59regulation of triglyceride catabolic process (GO:0010896)4.93620596
60cysteine metabolic process (GO:0006534)4.92594851
61negative regulation of cholesterol transport (GO:0032375)4.90684785
62negative regulation of sterol transport (GO:0032372)4.90684785
63detection of molecule of bacterial origin (GO:0032490)4.89879102
64bile acid metabolic process (GO:0008206)4.87009225
65tyrosine metabolic process (GO:0006570)4.81458095
66parturition (GO:0007567)4.77324718
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.74932569
68plasma lipoprotein particle clearance (GO:0034381)4.72409287
69cellular response to dexamethasone stimulus (GO:0071549)4.70174541
70triglyceride homeostasis (GO:0070328)4.62839467
71acylglycerol homeostasis (GO:0055090)4.62839467
72amino-acid betaine metabolic process (GO:0006577)4.62614015
73response to vitamin E (GO:0033197)4.62179867
74aromatic amino acid family metabolic process (GO:0009072)4.62105678
75cytokine metabolic process (GO:0042107)4.54679838
76regulation of male gonad development (GO:2000018)4.47936007
77cellular ketone body metabolic process (GO:0046950)4.47411268
78cholesterol efflux (GO:0033344)4.46923177
79alpha-amino acid catabolic process (GO:1901606)4.42767243
80response to dexamethasone (GO:0071548)4.37518879
81regulation of female gonad development (GO:2000194)4.31495821
82regulation of protein activation cascade (GO:2000257)4.30515615
83homocysteine metabolic process (GO:0050667)4.28252461
84complement activation, alternative pathway (GO:0006957)4.24797599
85plasma lipoprotein particle assembly (GO:0034377)4.23581940
86* benzene-containing compound metabolic process (GO:0042537)4.22715922
87negative regulation of lipase activity (GO:0060192)4.22476551
88lysine metabolic process (GO:0006553)4.22427681
89lysine catabolic process (GO:0006554)4.22427681
90drug catabolic process (GO:0042737)4.17275208
91* steroid biosynthetic process (GO:0006694)4.15996379
92vitamin D metabolic process (GO:0042359)4.09704951
93* sterol metabolic process (GO:0016125)4.06682191
94cellular amino acid catabolic process (GO:0009063)4.06507769
95cellular glucuronidation (GO:0052695)4.05994255
96positive regulation of triglyceride biosynthetic process (GO:0010867)4.05916635
97bile acid and bile salt transport (GO:0015721)4.04244909
98positive regulation of lipid catabolic process (GO:0050996)4.03166726
99low-density lipoprotein particle remodeling (GO:0034374)4.02775680
100glycine metabolic process (GO:0006544)4.02408777
101aggressive behavior (GO:0002118)4.02327159
102cellular response to monoamine stimulus (GO:0071868)4.00898390
103cellular response to catecholamine stimulus (GO:0071870)4.00898390
104imidazole-containing compound metabolic process (GO:0052803)4.00125954
105glutamate metabolic process (GO:0006536)3.95355707
106arginine metabolic process (GO:0006525)3.95214025
107ethanol oxidation (GO:0006069)3.93973452
108regulation of female receptivity (GO:0045924)3.93851943
109coenzyme catabolic process (GO:0009109)3.91058636
110regulation of complement activation (GO:0030449)3.90187887
111very-low-density lipoprotein particle assembly (GO:0034379)3.90151352
112phospholipid homeostasis (GO:0055091)3.89994519
113serine family amino acid metabolic process (GO:0009069)3.88859901
114serine family amino acid biosynthetic process (GO:0009070)3.85148327
115ketone body metabolic process (GO:1902224)3.85140443
116plasma lipoprotein particle organization (GO:0071827)3.84292194
117indolalkylamine metabolic process (GO:0006586)3.83499584
118regulation of apoptotic cell clearance (GO:2000425)3.82277771
119flavonoid metabolic process (GO:0009812)3.79961047
120protein-lipid complex assembly (GO:0065005)3.79285110
121cholesterol homeostasis (GO:0042632)3.78612117
122positive regulation of lipoprotein lipase activity (GO:0051006)3.78210401
123positive regulation of triglyceride lipase activity (GO:0061365)3.78210401
124short-chain fatty acid metabolic process (GO:0046459)3.77310137
125regulation of cholesterol biosynthetic process (GO:0045540)3.76674807
126drug metabolic process (GO:0017144)3.72804272
127sterol homeostasis (GO:0055092)3.71994640
128cellular modified amino acid catabolic process (GO:0042219)3.71674948
129fibrinolysis (GO:0042730)3.71618881
130aldehyde catabolic process (GO:0046185)3.71585137
131cellular biogenic amine catabolic process (GO:0042402)3.69737231
132amine catabolic process (GO:0009310)3.69737231
133response to monoamine (GO:0071867)3.69533936
134response to catecholamine (GO:0071869)3.69533936
135positive regulation of fatty acid beta-oxidation (GO:0032000)3.68130914
136linoleic acid metabolic process (GO:0043651)3.68109908
137dicarboxylic acid biosynthetic process (GO:0043650)3.68060107
138regulation of transmission of nerve impulse (GO:0051969)3.65163399
139organic acid catabolic process (GO:0016054)3.64791028
140carboxylic acid catabolic process (GO:0046395)3.64791028
141cofactor catabolic process (GO:0051187)3.62780891
142very long-chain fatty acid metabolic process (GO:0000038)3.61646722
143protein-lipid complex subunit organization (GO:0071825)3.61106277
144purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.58898239
1453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.58898239
146* cellular hormone metabolic process (GO:0034754)3.56971233
147uronic acid metabolic process (GO:0006063)3.56451681
148glucuronate metabolic process (GO:0019585)3.56451681
149response to water (GO:0009415)3.56441915
150response to growth hormone (GO:0060416)3.52496044
151carnitine metabolic process (GO:0009437)3.52103784
152cholesterol transport (GO:0030301)3.51572209
153sterol transport (GO:0015918)3.51572209
154positive regulation of nitric-oxide synthase activity (GO:0051000)3.51270755
155lipoprotein metabolic process (GO:0042157)3.49867899
156blood coagulation, intrinsic pathway (GO:0007597)3.49786729
157* cellular ketone metabolic process (GO:0042180)3.40249482
158female mating behavior (GO:0060180)3.38964486
159adhesion of symbiont to host (GO:0044406)3.38674148
160negative regulation of cytosolic calcium ion concentration (GO:0051481)3.35627552
161cholesterol metabolic process (GO:0008203)3.32292826
162response to cadmium ion (GO:0046686)3.22056714
163steroid catabolic process (GO:0006706)3.20226326
164sulfation (GO:0051923)3.19468470
165cholesterol catabolic process (GO:0006707)3.18909331
166sterol catabolic process (GO:0016127)3.18909331
167opsonization (GO:0008228)3.18822256
168positive regulation of amino acid transport (GO:0051957)3.09487402
169regulation of cholesterol homeostasis (GO:2000188)3.09315007
170* regulation of steroid biosynthetic process (GO:0050810)3.09177946
171regulation of cholesterol storage (GO:0010885)3.04975555
172regulation of triglyceride biosynthetic process (GO:0010866)3.04875381
173response to lipoprotein particle (GO:0055094)3.03620290
174cellular sodium ion homeostasis (GO:0006883)2.93916321
175cellular response to cAMP (GO:0071320)2.91524313
176response to interferon-alpha (GO:0035455)2.89979308
177regulation of cholesterol metabolic process (GO:0090181)2.88286434
178maintenance of protein location in nucleus (GO:0051457)2.83345916
179multi-organism reproductive behavior (GO:0044705)2.78491432
180multicellular organismal aging (GO:0010259)2.77134826
181positive regulation of triglyceride metabolic process (GO:0090208)2.75203090
182* adrenal gland development (GO:0030325)2.72994096
183positive regulation of monooxygenase activity (GO:0032770)2.68743547
184* glucocorticoid biosynthetic process (GO:0006704)19.2719285
185C21-steroid hormone biosynthetic process (GO:0006700)17.4187606
186cellular response to follicle-stimulating hormone stimulus (GO:0071372)15.5398658
187* glucocorticoid metabolic process (GO:0008211)15.0944804
188response to follicle-stimulating hormone (GO:0032354)12.4389096
189* androgen biosynthetic process (GO:0006702)12.4105073
190estrogen biosynthetic process (GO:0006703)12.3343731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.11078183
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.87787033
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.41313417
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.36295513
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.84335778
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.01748153
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.97686838
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.66765676
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.84637207
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.77788139
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.55241897
12EZH2_22144423_ChIP-Seq_EOC_Human3.27397666
13GBX2_23144817_ChIP-Seq_PC3_Human2.99076161
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.87110517
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.59573105
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51859755
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44086788
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40797609
19* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5275996
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97740008
21SRY_22984422_ChIP-ChIP_TESTIS_Rat1.95027104
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89214593
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69046687
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.68300962
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67490879
26CLOCK_20551151_ChIP-Seq_293T_Human1.65896266
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65882026
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.60158990
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60081191
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58772945
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.58697957
32* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.58327487
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.55565909
34HTT_18923047_ChIP-ChIP_STHdh_Human1.55053547
35AR_25329375_ChIP-Seq_VCAP_Human1.50624773
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48716383
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47483110
38SMAD4_21799915_ChIP-Seq_A2780_Human1.41894173
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39448787
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.38584320
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38077772
42AR_21572438_ChIP-Seq_LNCaP_Human1.35870618
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34238995
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34053049
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.33162328
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32562184
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32562184
48* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32476635
49TCF4_22108803_ChIP-Seq_LS180_Human1.23557491
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23535260
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.22370242
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18941809
53RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18315691
54LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17793320
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15948500
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.13329509
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.13240072
58TCF4_23295773_ChIP-Seq_U87_Human1.11144045
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10279676
60AHR_22903824_ChIP-Seq_MCF-7_Human1.08480225
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08402046
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08222400
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06572983
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06163381
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05901852
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05350294
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05350294
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04519567
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.02200913
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01524445
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01083540
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00265250
73WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99464962
74POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98596195
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98257322
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97406323
77TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96708467
78* GF1_26923725_Chip-Seq_HPCs_Mouse0.95757761
79DROSHA_22980978_ChIP-Seq_HELA_Human0.95714478
80KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95103244
81ZNF263_19887448_ChIP-Seq_K562_Human0.94715181
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94650755
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94471006
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93911429
85GATA1_22025678_ChIP-Seq_K562_Human0.93798971
86POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93760294
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92455755
88SOX2_21211035_ChIP-Seq_LN229_Gbm0.91287563
89VDR_22108803_ChIP-Seq_LS180_Human0.90937435
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89958738
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.89548008
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89327823
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87580628
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86913202
95SMAD3_21741376_ChIP-Seq_HESCs_Human0.86660766
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86101216
97* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85514868
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85489811
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84783643
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83844023
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82718770
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81685049
103* GATA4_25053715_ChIP-Seq_YYC3_Human0.80270743
104RARA_24833708_ChIP-Seq_LIVER_Mouse0.80184810
105* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79777032
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79564864
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77809252
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77614388
109* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77214419
110STAT1_17558387_ChIP-Seq_HELA_Human0.76078407
111STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73562693
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.70519109
113LXR_22292898_ChIP-Seq_THP-1_Human0.69344445
114P53_21459846_ChIP-Seq_SAOS-2_Human0.68860319
115CEBPB_22108803_ChIP-Seq_LS180_Human0.67636897
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67039765
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66670048
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.66456911
119RARB_24833708_ChIP-Seq_LIVER_Mouse0.65809088
120ESET_19884257_ChIP-Seq_ESCs_Mouse0.65274527
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63584254
122BCAT_22108803_ChIP-Seq_LS180_Human0.63518859
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63309001
124RARG_19884340_ChIP-ChIP_MEFs_Mouse0.62345786
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.62316681
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.60948640
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59435887
128MYC_19915707_ChIP-ChIP_AK7_Human0.58260309
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.57217290
130MYC_27129775_Chip-Seq_CORNEA_Mouse0.56452635
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55060674
132EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.54521418
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.54304811
134GATA1_19941826_ChIP-Seq_K562_Human0.53441560
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.52818681
136SOX2_22085726_ChIP-Seq_NPCs_Mouse0.51852048
137* CBP_21632823_ChIP-Seq_H3396_Human0.51382264
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49899717
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.48725490
140SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.48648207
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.48405550
142GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.48396883
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.47922687
144CDX2_22108803_ChIP-Seq_LS180_Human0.47588821
145PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47585094
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.47380863
147* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.47195158
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.46746650
149AR_20517297_ChIP-Seq_VCAP_Human0.46623661
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.46184595
151CTCF_27219007_Chip-Seq_Bcells_Human0.45688728
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.45242195
153FOXA1_25552417_ChIP-Seq_VCAP_Human0.45212159
154CSB_26484114_Chip-Seq_FIBROBLAST_Human0.44792722
155TAF15_26573619_Chip-Seq_HEK293_Human0.44581935
156FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.44558185
157PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44078563
158SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43695708
159GATA2_19941826_ChIP-Seq_K562_Human0.43231610
160* TBX20_22328084_ChIP-Seq_HEART_Mouse0.43108657
161* TBX20_22080862_ChIP-Seq_HEART_Mouse0.43108657
162TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.42691484
163SOX11_22085726_ChIP-Seq_ESNs_Mouse0.42662804
164MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.41932812
165SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.41849917
166NRF2_20460467_ChIP-Seq_MEFs_Mouse0.40992843
167NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.40992843
168* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.40897252
169SOX2_21211035_ChIP-Seq_LN229_Human0.40547291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.54065716
2MP0002909_abnormal_adrenal_gland7.73150222
3MP0005360_urolithiasis7.23001541
4MP0005085_abnormal_gallbladder_physiolo6.03577386
5MP0005365_abnormal_bile_salt6.02082740
6MP0008875_abnormal_xenobiotic_pharmacok5.31125489
7MP0008004_abnormal_stomach_pH4.21988393
8MP0010329_abnormal_lipoprotein_level3.73454029
9MP0003806_abnormal_nucleotide_metabolis3.69576995
10MP0003252_abnormal_bile_duct3.61913017
11MP0009840_abnormal_foam_cell3.54580674
12MP0003941_abnormal_skin_development3.30383458
13MP0003122_maternal_imprinting3.12154642
14MP0005083_abnormal_biliary_tract2.95532096
15MP0003195_calcinosis2.86903694
16MP0005332_abnormal_amino_acid2.74893685
17MP0005379_endocrine/exocrine_gland_phen2.38769167
18MP0003191_abnormal_cellular_cholesterol2.35435017
19MP0001984_abnormal_olfaction2.34811000
20MP0001666_abnormal_nutrient_absorption2.32662090
21MP0004019_abnormal_vitamin_homeostasis2.27848691
22MP0001765_abnormal_ion_homeostasis2.18811640
23MP0002118_abnormal_lipid_homeostasis2.15839593
24MP0000609_abnormal_liver_physiology2.15453007
25MP0003315_abnormal_perineum_morphology2.12635224
26MP0009780_abnormal_chondrocyte_physiolo2.12630643
27MP0000647_abnormal_sebaceous_gland1.98918982
28MP0003011_delayed_dark_adaptation1.96815105
29MP0000631_abnormal_neuroendocrine_gland1.92238327
30MP0002138_abnormal_hepatobiliary_system1.76554843
31MP0005410_abnormal_fertilization1.75359104
32MP0005451_abnormal_body_composition1.74080891
33MP0005319_abnormal_enzyme/_coenzyme1.73174159
34MP0001879_abnormal_lymphatic_vessel1.71804162
35MP0003868_abnormal_feces_composition1.62657084
36MP0006276_abnormal_autonomic_nervous1.58003206
37MP0005584_abnormal_enzyme/coenzyme_acti1.55794783
38MP0005646_abnormal_pituitary_gland1.54859460
39MP0002269_muscular_atrophy1.51788959
40MP0003705_abnormal_hypodermis_morpholog1.50201391
41MP0001485_abnormal_pinna_reflex1.49737628
42MP0001764_abnormal_homeostasis1.48793460
43MP0002160_abnormal_reproductive_system1.46550395
44MP0003121_genomic_imprinting1.43765091
45MP0009697_abnormal_copulation1.41834810
46MP0005647_abnormal_sex_gland1.41388516
47MP0005670_abnormal_white_adipose1.22795304
48MP0001119_abnormal_female_reproductive1.20950877
49MP0003878_abnormal_ear_physiology1.18563025
50MP0005377_hearing/vestibular/ear_phenot1.18563025
51MP0000604_amyloidosis1.16894376
52MP0009643_abnormal_urine_homeostasis1.16199785
53MP0003950_abnormal_plasma_membrane1.15726601
54MP0000598_abnormal_liver_morphology1.14988039
55MP0004134_abnormal_chest_morphology1.11434588
56MP0001661_extended_life_span1.07571692
57MP0002254_reproductive_system_inflammat1.06151481
58MP0010368_abnormal_lymphatic_system1.05031418
59MP0003186_abnormal_redox_activity1.04686703
60MP0000639_abnormal_adrenal_gland1.02449716
61MP0000013_abnormal_adipose_tissue0.97930879
62MP0004085_abnormal_heartbeat0.97907876
63MP0009053_abnormal_anal_canal0.97632253
64MP0003656_abnormal_erythrocyte_physiolo0.96790842
65MP0009763_increased_sensitivity_to0.95754326
66MP0005636_abnormal_mineral_homeostasis0.92556283
67MP0005408_hypopigmentation0.89140368
68MP0001915_intracranial_hemorrhage0.87611482
69MP0002938_white_spotting0.87531863
70* MP0009642_abnormal_blood_homeostasis0.86720274
71MP0000751_myopathy0.86180460
72MP0009764_decreased_sensitivity_to0.83874365
73MP0004484_altered_response_of0.81466017
74MP0005595_abnormal_vascular_smooth0.78364243
75MP0002971_abnormal_brown_adipose0.76726997
76MP0002078_abnormal_glucose_homeostasis0.74613049
77MP0005253_abnormal_eye_physiology0.74337704
78MP0003959_abnormal_lean_body0.73919053
79MP0008469_abnormal_protein_level0.73424559
80MP0005376_homeostasis/metabolism_phenot0.72880242
81MP0006036_abnormal_mitochondrial_physio0.72055494
82MP0004130_abnormal_muscle_cell0.71847500
83MP0005334_abnormal_fat_pad0.71816984
84MP0005275_abnormal_skin_tensile0.71679524
85MP0009765_abnormal_xenobiotic_induced0.68086683
86MP0003329_amyloid_beta_deposits0.67150916
87MP0002127_abnormal_cardiovascular_syste0.65371263
88* MP0002557_abnormal_social/conspecific_i0.65125393
89MP0003690_abnormal_glial_cell0.63975153
90MP0002998_abnormal_bone_remodeling0.63445433
91MP0004272_abnormal_basement_membrane0.63243121
92MP0002876_abnormal_thyroid_physiology0.62643309
93MP0002796_impaired_skin_barrier0.61357995
94MP0003279_aneurysm0.61260772
95MP0001756_abnormal_urination0.60955179
96MP0005535_abnormal_body_temperature0.58443688
97MP0005666_abnormal_adipose_tissue0.58331575
98MP0005448_abnormal_energy_balance0.56712882
99MP0000653_abnormal_sex_gland0.56546758
100MP0005266_abnormal_metabolism0.56084320
101MP0004742_abnormal_vestibular_system0.55541158
102MP0001905_abnormal_dopamine_level0.55415727
103MP0002210_abnormal_sex_determination0.54838723
104MP0005167_abnormal_blood-brain_barrier0.54837419
105MP0005248_abnormal_Harderian_gland0.54356593
106MP0005395_other_phenotype0.53898288
107MP0001486_abnormal_startle_reflex0.53075286
108* MP0003698_abnormal_male_reproductive0.52642527
109MP0003879_abnormal_hair_cell0.51957458
110MP0002896_abnormal_bone_mineralization0.51651679
111MP0005257_abnormal_intraocular_pressure0.51190840
112MP0003632_abnormal_nervous_system0.50225720
113MP0009672_abnormal_birth_weight0.49042860
114MP0008057_abnormal_DNA_replication0.48675779
115MP0006035_abnormal_mitochondrial_morpho0.47384719
116MP0003137_abnormal_impulse_conducting0.47254981
117MP0003300_gastrointestinal_ulcer0.47022346
118* MP0001929_abnormal_gametogenesis0.46882448
119MP0002168_other_aberrant_phenotype0.46339803
120MP0004145_abnormal_muscle_electrophysio0.45916021
121MP0000343_altered_response_to0.45857175
122* MP0003953_abnormal_hormone_level0.45805926
123MP0005464_abnormal_platelet_physiology0.45732312
124MP0008438_abnormal_cutaneous_collagen0.45729623
125MP0003638_abnormal_response/metabolism_0.45620813
126MP0008770_decreased_survivor_rate0.44747989
127MP0005164_abnormal_response_to0.44208889
128MP0001324_abnormal_eye_pigmentation0.43438319
129MP0005220_abnormal_exocrine_pancreas0.43188177
130MP0001145_abnormal_male_reproductive0.42204796
131MP0001243_abnormal_dermal_layer0.42067196
132MP0002136_abnormal_kidney_physiology0.41895195
133MP0001727_abnormal_embryo_implantation0.41269954
134MP0002115_abnormal_skeleton_extremities0.40896782
135MP0000462_abnormal_digestive_system0.39811078
136MP0008874_decreased_physiological_sensi0.38703087
137MP0003718_maternal_effect0.38105282
138MP0009384_cardiac_valve_regurgitation0.37763288
139MP0004883_abnormal_blood_vessel0.37187193
140MP0001299_abnormal_eye_distance/0.36913346
141MP0002970_abnormal_white_adipose0.36134735
142MP0002282_abnormal_trachea_morphology0.35619365
143MP0005330_cardiomyopathy0.35243577
144MP0005389_reproductive_system_phenotype0.35005000
145* MP0002161_abnormal_fertility/fecundity0.34892359
146MP0009115_abnormal_fat_cell0.34626993
147MP0003634_abnormal_glial_cell0.34617873
148MP0005084_abnormal_gallbladder_morpholo0.34388443
149MP0000750_abnormal_muscle_regeneration0.34357909
150MP0005391_vision/eye_phenotype0.33391962
151MP0000249_abnormal_blood_vessel0.33329255
152MP0004185_abnormal_adipocyte_glucose0.33067860
153MP0002837_dystrophic_cardiac_calcinosis0.33014149
154MP0002060_abnormal_skin_morphology0.32841967
155MP0008873_increased_physiological_sensi0.32829213
156MP0005187_abnormal_penis_morphology0.32766325
157MP0002090_abnormal_vision0.28360216
158MP0001881_abnormal_mammary_gland0.27931997
159MP0000230_abnormal_systemic_arterial0.27851659
160MP0003699_abnormal_female_reproductive0.27833067
161MP0002822_catalepsy0.27766143
162MP0002928_abnormal_bile_duct0.27358841
163MP0003115_abnormal_respiratory_system0.27297059
164MP0003075_altered_response_to0.26584066
165MP0006082_CNS_inflammation0.25596380

Predicted human phenotypes

RankGene SetZ-score
1Hyperaldosteronism (HP:0000859)9.91590691
2Sex reversal (HP:0012245)7.72924956
3Abnormal sex determination (HP:0012244)7.72924956
4Deep venous thrombosis (HP:0002625)7.70308109
5Abnormality of aromatic amino acid family metabolism (HP:0004338)7.47487535
6Hypoplasia of the uterus (HP:0000013)7.46971551
7Hypobetalipoproteinemia (HP:0003563)6.77688318
8Abnormality of monocarboxylic acid metabolism (HP:0010996)6.70754215
9Intrahepatic cholestasis (HP:0001406)6.48319893
10Prolonged partial thromboplastin time (HP:0003645)6.23783305
11Xanthomatosis (HP:0000991)6.13168922
12Hyperlipoproteinemia (HP:0010980)5.93468227
13Aplasia/hypoplasia of the uterus (HP:0008684)5.38034952
14Clitoromegaly (HP:0000057)5.22142235
15Hypolipoproteinemia (HP:0010981)5.18774791
16Adrenal overactivity (HP:0002717)5.16950204
17Abnormality of renin-angiotensin system (HP:0000847)5.14297874
18Testicular neoplasm (HP:0010788)4.91401792
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.71016988
20Hypoalphalipoproteinemia (HP:0003233)4.67147946
21Hyperammonemia (HP:0001987)4.64677037
22Joint hemorrhage (HP:0005261)4.61397580
23Ketosis (HP:0001946)4.38754221
24Epidermoid cyst (HP:0200040)4.31389866
25Abnormality of methionine metabolism (HP:0010901)4.30899822
26Gonadal dysgenesis (HP:0000133)4.18177598
27Abnormality of the common coagulation pathway (HP:0010990)4.17122175
28Abnormality of sulfur amino acid metabolism (HP:0004339)4.17083156
29Hyperglycinemia (HP:0002154)4.16776396
30Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14403247
31Abnormality of glutamine family amino acid metabolism (HP:0010902)4.07431362
32Recurrent gram-negative bacterial infections (HP:0005420)3.92305590
33Complement deficiency (HP:0004431)3.89245659
34Hypercholesterolemia (HP:0003124)3.89138956
35Hypoglycemic coma (HP:0001325)3.83200330
36Abnormality of pyrimidine metabolism (HP:0004353)3.78501008
37Abnormality of serine family amino acid metabolism (HP:0010894)3.78148916
38Abnormality of glycine metabolism (HP:0010895)3.78148916
39Hyperglycinuria (HP:0003108)3.76534384
40Accelerated skeletal maturation (HP:0005616)3.68382881
41Hypokalemia (HP:0002900)3.62439084
42Abnormality of the intrinsic pathway (HP:0010989)3.47494916
43Fat malabsorption (HP:0002630)3.47361044
44Abnormality of the clitoris (HP:0000056)3.44705765
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42090443
46Abnormality of fatty-acid metabolism (HP:0004359)3.32999483
47Abnormality of secondary sexual hair (HP:0009888)3.30665251
48Abnormality of the axillary hair (HP:0100134)3.30665251
49Secondary amenorrhea (HP:0000869)3.26552640
50Hyperbilirubinemia (HP:0002904)3.24220376
51* Male pseudohermaphroditism (HP:0000037)3.07170060
52Conjugated hyperbilirubinemia (HP:0002908)3.06421081
53Ketoacidosis (HP:0001993)3.04181855
54Abnormality of nucleobase metabolism (HP:0010932)3.00540078
55Abnormality of serum amino acid levels (HP:0003112)2.92345794
56Delayed CNS myelination (HP:0002188)2.90816282
57Vascular calcification (HP:0004934)2.89667348
58Abnormal spermatogenesis (HP:0008669)2.88565066
59Spontaneous abortion (HP:0005268)2.85961355
60Myocardial infarction (HP:0001658)2.85764658
61Abnormality of complement system (HP:0005339)2.85302525
62Premature ovarian failure (HP:0008209)2.81586492
63Neurofibrillary tangles (HP:0002185)2.78336028
64Hepatocellular carcinoma (HP:0001402)2.77729048
65Hyperpituitarism (HP:0010514)2.75230127
66Hypospadias (HP:0000047)2.74335329
67Cardiovascular calcification (HP:0011915)2.72015724
68Decreased testicular size (HP:0008734)2.70624756
69Asymmetric septal hypertrophy (HP:0001670)2.67961988
70Skin nodule (HP:0200036)2.66241032
71Metabolic acidosis (HP:0001942)2.65603325
72Abnormality of purine metabolism (HP:0004352)2.61559613
73Dicarboxylic aciduria (HP:0003215)2.59991320
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59991320
75Abnormality of potassium homeostasis (HP:0011042)2.56725625
76Congenital sensorineural hearing impairment (HP:0008527)2.56115380
77Choanal stenosis (HP:0000452)2.55722748
78Ventricular fibrillation (HP:0001663)2.52244293
79Spastic diplegia (HP:0001264)2.50422572
80Mitral stenosis (HP:0001718)2.50064802
81Steatorrhea (HP:0002570)2.49224343
82Lethargy (HP:0001254)2.45916921
83Cholecystitis (HP:0001082)2.44173627
84Abnormal gallbladder physiology (HP:0012438)2.44173627
85Male infertility (HP:0003251)2.38153252
86Malnutrition (HP:0004395)2.37912488
87Large earlobe (HP:0009748)2.36921814
88Mesangial abnormality (HP:0001966)2.36573577
89Acanthocytosis (HP:0001927)2.34511746
90Cerebral edema (HP:0002181)2.34382070
91Urinary glycosaminoglycan excretion (HP:0003541)2.34360635
92Mucopolysacchariduria (HP:0008155)2.34360635
93Amyloidosis (HP:0011034)2.33529828
94Hypochromic microcytic anemia (HP:0004840)2.33375485
95Abnormal gallbladder morphology (HP:0012437)2.32894680
96Irritability (HP:0000737)2.32502235
97Glomerulonephritis (HP:0000099)2.30313506
98Bicornuate uterus (HP:0000813)2.29153628
99Brushfield spots (HP:0001088)2.28557360
100Hypoglycemic seizures (HP:0002173)2.27086884
101Cholelithiasis (HP:0001081)2.26391068
102Aplasia of the musculature (HP:0100854)2.26351653
103Precocious puberty (HP:0000826)2.25406753
104Atrioventricular block (HP:0001678)2.21047826
105Hemorrhage of the eye (HP:0011885)2.20060456
106Bifid tongue (HP:0010297)2.19369592
107Tracheal stenosis (HP:0002777)2.18944034
108Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16714971
109Abnormality of polysaccharide metabolism (HP:0011012)2.16714971
110Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16714971
111Esophageal varix (HP:0002040)2.13015704
112Menorrhagia (HP:0000132)2.11486645
113Neonatal onset (HP:0003623)2.08133339
114Absent eyebrow (HP:0002223)2.07859417
115Nausea (HP:0002018)2.06980822
116Late onset (HP:0003584)2.06900210
117Gout (HP:0001997)2.05904345
118Cerebral inclusion bodies (HP:0100314)2.05634502
119Vomiting (HP:0002013)2.04604315
120Female pseudohermaphroditism (HP:0010458)2.04526042
121Enlarged kidneys (HP:0000105)2.03173216
122Thrombophlebitis (HP:0004418)2.02259642
123Abnormal cartilage morphology (HP:0002763)2.00259496
124Renal salt wasting (HP:0000127)13.7790898
125Decreased circulating renin level (HP:0003351)11.0155728
126Enlarged penis (HP:0000040)10.2738717
127Metaphyseal dysplasia (HP:0100255)1.97588952
128Bilateral microphthalmos (HP:0007633)1.97110179
129Systemic lupus erythematosus (HP:0002725)1.96742691
130Morphological abnormality of the middle ear (HP:0008609)1.96338690
131Pancreatitis (HP:0001733)1.95159665
132Prolonged QT interval (HP:0001657)1.94313134
133Hyperinsulinemic hypoglycemia (HP:0000825)1.94021379
134Azoospermia (HP:0000027)1.91819758
135Generalized aminoaciduria (HP:0002909)1.89830107
136Gingival bleeding (HP:0000225)1.89156192
137Infertility (HP:0000789)1.87432386
138Abnormal pancreas size (HP:0012094)1.86720489
139Abnormality of the gallbladder (HP:0005264)1.86551426
140Nephritis (HP:0000123)1.86478458
141Poikilocytosis (HP:0004447)1.84518125
142Hypertriglyceridemia (HP:0002155)1.81456729
143Stroke (HP:0001297)1.81414238
144Reticulocytosis (HP:0001923)1.81078656
145Abnormality of the Achilles tendon (HP:0005109)1.80725117
146Syncope (HP:0001279)1.80318799
147Hydroxyprolinuria (HP:0003080)1.79926522
148Abnormality of proline metabolism (HP:0010907)1.79926522
149Abnormality of the lower motor neuron (HP:0002366)1.79338461
150Renal cortical cysts (HP:0000803)1.77375108
151Status epilepticus (HP:0002133)1.75777496
152Acne (HP:0001061)1.74845711
153Bilateral sensorineural hearing impairment (HP:0008619)1.74590824
154Upper motor neuron abnormality (HP:0002127)1.74552967
155Sensorimotor neuropathy (HP:0007141)1.74092447
156Cervical subluxation (HP:0003308)1.73299690
157Gonadotropin excess (HP:0000837)1.72008251
158* Gynecomastia (HP:0000771)1.66901625
159Midline defect of the nose (HP:0004122)1.62401996
160Cerebral palsy (HP:0100021)1.59807556
161Breast hypoplasia (HP:0003187)1.57279137
162Sparse lateral eyebrow (HP:0005338)1.56883557
163Absent hair (HP:0002298)1.53733416
164Short humerus (HP:0005792)1.52402027
165Cutaneous finger syndactyly (HP:0010554)1.51706404
166Osteolytic defects of the hand bones (HP:0009699)1.51356997
167Osteolytic defects of the phalanges of the hand (HP:0009771)1.51356997
168Myelomeningocele (HP:0002475)1.51141449
169Hypoplastic nipples (HP:0002557)1.50818130
170Neonatal hypoglycemia (HP:0001998)1.48706888
171Abnormality of carpal bone ossification (HP:0006257)1.48281412
172Hip contracture (HP:0003273)1.46788467
173Visceral angiomatosis (HP:0100761)1.46203806
174Absent hand (HP:0004050)1.46057405
175Limited hip movement (HP:0008800)1.45531278
176Absent eyelashes (HP:0000561)1.45099354
177Ovarian neoplasm (HP:0100615)1.41268139
178Persistence of primary teeth (HP:0006335)1.39971803
179Thoracolumbar scoliosis (HP:0002944)1.38103392
180Abnormality of the aortic arch (HP:0012303)1.38084252
181Cupped ear (HP:0000378)1.37675253
182Wrist flexion contracture (HP:0001239)1.37452809
183Hemangiomatosis (HP:0007461)1.36368135
184Scrotal hypoplasia (HP:0000046)1.36366508
185Aplasia/hypoplasia of the humerus (HP:0006507)1.35360665
186Abnormality of the pubic bones (HP:0003172)1.35076606
187Breech presentation (HP:0001623)1.34594240
188Abnormal EKG (HP:0003115)1.34401599
189Primary adrenal insufficiency (HP:0008207)1.34340621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.63191163
2SIK14.24433949
3DDR23.70011354
4FGFR43.66856230
5ERN13.54538708
6PDK43.46430175
7PDK33.46430175
8TRIB33.34123445
9PKN23.09116951
10MELK3.04578660
11MAP3K52.37589902
12ICK2.18980552
13INSRR2.18514965
14LATS12.14288505
15AKT311.6411617
16MAP2K41.97242508
17PDK21.95730321
18DAPK21.89229781
19PTK61.85370280
20TAOK31.81198828
21AKT21.76543359
22FLT31.73042375
23PIK3CG1.65265372
24MST1R1.64859713
25MAP3K101.40891683
26FGFR21.37872679
27RIPK11.30848838
28ERBB41.24804628
29PDGFRA1.22009135
30TYK21.21717420
31PIM11.20864663
32GRK51.16539973
33CAMK1D1.15669164
34SCYL21.14687255
35ABL21.08694491
36MAPK111.08406330
37EEF2K1.08397279
38DYRK1B1.08209451
39NTRK11.06079447
40KDR1.04125091
41TRPM70.98707590
42STK38L0.96044394
43MAP2K60.94418110
44TESK10.93569507
45MAP3K30.91902549
46FRK0.90318429
47PRKAA20.88689920
48NLK0.88111519
49MAP3K70.87163311
50JAK20.87089734
51SGK10.87011501
52PRKD30.86922536
53CAMK1G0.86342957
54PINK10.84484443
55MAPK40.83932313
56TYRO30.82849759
57CDK60.82671150
58PTK2B0.82649899
59EPHB20.81966820
60PRKCZ0.81028931
61MET0.77224741
62PRKACG0.76641224
63MAPK120.76073353
64YES10.73605333
65PDK10.72764762
66WNK30.72635880
67CDK40.72606688
68PDPK10.70464299
69STK100.70157336
70CSK0.70146479
71NEK90.68815730
72MAPK30.68440041
73MTOR0.67828051
74MAP2K30.66981496
75ERBB20.66337376
76TBK10.65880703
77LATS20.64216491
78TGFBR20.61707572
79GSK3A0.61349755
80PTK20.60704392
81EPHB10.59387166
82CSNK1A1L0.58356885
83STK30.57137560
84EPHA30.57028341
85GRK60.54305854
86RET0.54126195
87STK380.51711446
88WNK40.51693258
89PHKG10.50617579
90PHKG20.50617579
91ACVR1B0.50325937
92MAPKAPK50.49422060
93PRKAA10.48210598
94TIE10.47532827
95JAK10.47097443
96FER0.46089446
97MAPK150.44971423
98MAP3K20.44517145
99PAK20.44092616
100SGK20.43750809
101MAPK70.43701654
102CSNK1G20.42658591
103EPHA40.39966028
104ADRBK10.38903732
105PRKCG0.37273149
106IGF1R0.36591312
107MAP2K10.36578416
108MAP3K120.35438151
109PRKCQ0.34939973
110CSNK1G10.34337529
111CAMK2G0.33877257
112CSF1R0.33053942
113FGFR30.32996188
114OBSCN0.31735029
115SGK30.31441968
116MAP3K110.31396396
117PAK30.31182473
118CAMK40.30015342
119BMPR1B0.30001229
120* PRKACA0.29500485
121SGK2230.28267657
122SGK4940.28267657
123MYLK0.28106444
124ROCK20.27894752
125MAP4K20.27099351
126STK390.26717206
127TTN0.25859018
128LRRK20.24970472
129CAMKK10.24816182
130MAP3K140.24749140
131FGFR10.24427491
132MAPK10.24260486
133NTRK30.24222869
134MAP3K60.24135629
135PDGFRB0.23787915
136CAMKK20.23331538
137CDK70.22919908
138RPS6KB10.22860529
139MAP3K40.22815542
140CAMK10.22678161
141MAPKAPK30.22588762
142PRKACB0.22237090
143EGFR0.22016685
144RPS6KA30.21674735
145MAP2K20.21552602
146CDC42BPA0.20530663
147ROCK10.20185727
148CSNK1G30.20160108
149OXSR10.19694862
150MUSK0.19247864

Predicted pathways (KEGG)

RankGene SetZ-score
1Aldosterone synthesis and secretion_Homo sapiens_hsa049255.79120237
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.89463613
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.48419294
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.47149277
5Nitrogen metabolism_Homo sapiens_hsa009103.29951797
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27555485
7Arginine biosynthesis_Homo sapiens_hsa002202.92558368
8Fatty acid degradation_Homo sapiens_hsa000712.61493540
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49727351
10Tryptophan metabolism_Homo sapiens_hsa003802.49054507
11Complement and coagulation cascades_Homo sapiens_hsa046102.39060465
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37510091
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.32675709
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32128328
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31558584
16Propanoate metabolism_Homo sapiens_hsa006402.23595532
17Fatty acid metabolism_Homo sapiens_hsa012122.22067603
18* Steroid hormone biosynthesis_Homo sapiens_hsa001402.17990804
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.15347867
20Chemical carcinogenesis_Homo sapiens_hsa052042.14826859
21Butanoate metabolism_Homo sapiens_hsa006502.08082081
22PPAR signaling pathway_Homo sapiens_hsa033202.06847139
23Peroxisome_Homo sapiens_hsa041461.96071054
24Histidine metabolism_Homo sapiens_hsa003401.93808107
25Retinol metabolism_Homo sapiens_hsa008301.83272901
26Fatty acid elongation_Homo sapiens_hsa000621.75092323
27beta-Alanine metabolism_Homo sapiens_hsa004101.72804693
28Pyruvate metabolism_Homo sapiens_hsa006201.67945095
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.66375448
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65131946
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63089056
32Phenylalanine metabolism_Homo sapiens_hsa003601.61091881
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58542385
34Selenocompound metabolism_Homo sapiens_hsa004501.54419682
35Staphylococcus aureus infection_Homo sapiens_hsa051501.54095409
36Bile secretion_Homo sapiens_hsa049761.50220082
37Steroid biosynthesis_Homo sapiens_hsa001001.44241052
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42060318
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41883855
40Caffeine metabolism_Homo sapiens_hsa002321.41491786
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.34696006
42Tyrosine metabolism_Homo sapiens_hsa003501.32127841
43Sulfur metabolism_Homo sapiens_hsa009201.30268781
44Fat digestion and absorption_Homo sapiens_hsa049751.26317398
45Biosynthesis of amino acids_Homo sapiens_hsa012301.25403436
46Carbon metabolism_Homo sapiens_hsa012001.19943645
47Starch and sucrose metabolism_Homo sapiens_hsa005001.18893690
48ABC transporters_Homo sapiens_hsa020101.10233649
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.01697598
50Fatty acid biosynthesis_Homo sapiens_hsa000611.00092087
51Folate biosynthesis_Homo sapiens_hsa007900.97701960
52Vitamin digestion and absorption_Homo sapiens_hsa049770.96928193
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95440993
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93750921
55ECM-receptor interaction_Homo sapiens_hsa045120.93389395
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93286375
57Arginine and proline metabolism_Homo sapiens_hsa003300.93266720
58Lysine degradation_Homo sapiens_hsa003100.85105696
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83452515
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83383635
61Glycerolipid metabolism_Homo sapiens_hsa005610.82389338
62Vitamin B6 metabolism_Homo sapiens_hsa007500.74526052
63Sulfur relay system_Homo sapiens_hsa041220.73966725
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.73698412
65Glutathione metabolism_Homo sapiens_hsa004800.68580241
66Circadian rhythm_Homo sapiens_hsa047100.67812705
67Lysosome_Homo sapiens_hsa041420.63690696
68Pentose phosphate pathway_Homo sapiens_hsa000300.60759478
69One carbon pool by folate_Homo sapiens_hsa006700.55801059
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51324709
71Sphingolipid metabolism_Homo sapiens_hsa006000.50407901
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47898336
73Pertussis_Homo sapiens_hsa051330.47503243
74* Prolactin signaling pathway_Homo sapiens_hsa049170.45316101
75* Metabolic pathways_Homo sapiens_hsa011000.44100570
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.43624987
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43459551
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43210266
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.42378551
80Focal adhesion_Homo sapiens_hsa045100.41330888
81Systemic lupus erythematosus_Homo sapiens_hsa053220.36428710
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35192595
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35073408
84Linoleic acid metabolism_Homo sapiens_hsa005910.34562096
85Dorso-ventral axis formation_Homo sapiens_hsa043200.34444855
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31775303
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31624470
88Vibrio cholerae infection_Homo sapiens_hsa051100.31378604
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.28285375
90Other glycan degradation_Homo sapiens_hsa005110.27683298
91Calcium signaling pathway_Homo sapiens_hsa040200.27674039
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27575253
93GnRH signaling pathway_Homo sapiens_hsa049120.26455239
94Gastric acid secretion_Homo sapiens_hsa049710.26447485
95Glucagon signaling pathway_Homo sapiens_hsa049220.26176266
96Gap junction_Homo sapiens_hsa045400.25856177
97Amoebiasis_Homo sapiens_hsa051460.23432351
98Insulin resistance_Homo sapiens_hsa049310.23170976
99Small cell lung cancer_Homo sapiens_hsa052220.21502278
100Choline metabolism in cancer_Homo sapiens_hsa052310.19571429
101Fructose and mannose metabolism_Homo sapiens_hsa000510.18641554
102Dilated cardiomyopathy_Homo sapiens_hsa054140.18634172
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.17490072
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.14891748
105* Ovarian steroidogenesis_Homo sapiens_hsa049130.14640499
106Toxoplasmosis_Homo sapiens_hsa051450.13549258
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13470628
108Melanoma_Homo sapiens_hsa052180.13223813
109Galactose metabolism_Homo sapiens_hsa000520.12106500
110Hepatitis C_Homo sapiens_hsa051600.11860082
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11735926
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.11195966
113Pancreatic secretion_Homo sapiens_hsa049720.10037777
114mTOR signaling pathway_Homo sapiens_hsa041500.08804415
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.06499275
116FoxO signaling pathway_Homo sapiens_hsa040680.06316257
117Long-term depression_Homo sapiens_hsa047300.06300403
118AMPK signaling pathway_Homo sapiens_hsa041520.05914918
119Type II diabetes mellitus_Homo sapiens_hsa04930-0.2691673
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2593146
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.2468934
122Mineral absorption_Homo sapiens_hsa04978-0.2375436
123Ether lipid metabolism_Homo sapiens_hsa00565-0.2300900
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2258958
125Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2097595
126African trypanosomiasis_Homo sapiens_hsa05143-0.1935160
127Protein digestion and absorption_Homo sapiens_hsa04974-0.1821977
128Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1771239
129Renin-angiotensin system_Homo sapiens_hsa04614-0.1656017
130Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1528401
131Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1418738
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1318855
133Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1166689
134Insulin signaling pathway_Homo sapiens_hsa04910-0.1090543
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0992138
136Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0960310
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0937720
138Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0876814
139Prion diseases_Homo sapiens_hsa05020-0.0119123

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