CYP1A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* exogenous drug catabolic process (GO:0042738)8.29466945
2* drug catabolic process (GO:0042737)7.81586649
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.63498017
4L-phenylalanine catabolic process (GO:0006559)7.63498017
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25094396
6L-phenylalanine metabolic process (GO:0006558)7.25094396
7aromatic amino acid family catabolic process (GO:0009074)6.90091353
8indole-containing compound catabolic process (GO:0042436)6.21824955
9indolalkylamine catabolic process (GO:0046218)6.21824955
10tryptophan catabolic process (GO:0006569)6.21824955
11kynurenine metabolic process (GO:0070189)6.10140356
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.06224313
13* epoxygenase P450 pathway (GO:0019373)6.05619549
14bile acid biosynthetic process (GO:0006699)6.02874103
15tryptophan metabolic process (GO:0006568)5.88220144
16S-adenosylmethionine metabolic process (GO:0046500)5.85295635
17glyoxylate metabolic process (GO:0046487)5.68640220
18urea metabolic process (GO:0019627)5.65815420
19urea cycle (GO:0000050)5.65815420
20negative regulation of fibrinolysis (GO:0051918)5.53197965
21ethanol metabolic process (GO:0006067)5.42509090
22high-density lipoprotein particle remodeling (GO:0034375)5.39678846
23regulation of fibrinolysis (GO:0051917)5.37259267
24protein carboxylation (GO:0018214)5.36462643
25peptidyl-glutamic acid carboxylation (GO:0017187)5.36462643
26cysteine metabolic process (GO:0006534)5.35770593
27sulfur amino acid catabolic process (GO:0000098)5.32521777
28alpha-linolenic acid metabolic process (GO:0036109)5.27803179
29complement activation, alternative pathway (GO:0006957)5.24253265
30regulation of protein activation cascade (GO:2000257)5.20861769
31nitrogen cycle metabolic process (GO:0071941)5.19029787
32bile acid metabolic process (GO:0008206)5.16048755
33serine family amino acid catabolic process (GO:0009071)5.03158641
34aromatic amino acid family metabolic process (GO:0009072)5.00414353
35cellular glucuronidation (GO:0052695)4.97568976
36* oxidative demethylation (GO:0070989)4.95276395
37flavonoid metabolic process (GO:0009812)4.94966101
38regulation of complement activation (GO:0030449)4.89462533
39tyrosine metabolic process (GO:0006570)4.82531460
40homocysteine metabolic process (GO:0050667)4.77661106
41lysine metabolic process (GO:0006553)4.74034017
42lysine catabolic process (GO:0006554)4.74034017
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.71345775
44alpha-amino acid catabolic process (GO:1901606)4.70356519
45regulation of triglyceride catabolic process (GO:0010896)4.65923863
46amino-acid betaine metabolic process (GO:0006577)4.63761097
47reverse cholesterol transport (GO:0043691)4.62295002
48plasma lipoprotein particle remodeling (GO:0034369)4.54038230
49protein-lipid complex remodeling (GO:0034368)4.54038230
50macromolecular complex remodeling (GO:0034367)4.54038230
51regulation of cholesterol esterification (GO:0010872)4.51365344
52coenzyme catabolic process (GO:0009109)4.48930323
53triglyceride homeostasis (GO:0070328)4.47695886
54acylglycerol homeostasis (GO:0055090)4.47695886
55negative regulation of cholesterol transport (GO:0032375)4.46985016
56negative regulation of sterol transport (GO:0032372)4.46985016
57glucuronate metabolic process (GO:0019585)4.46104777
58uronic acid metabolic process (GO:0006063)4.46104777
59bile acid and bile salt transport (GO:0015721)4.42151740
60indolalkylamine metabolic process (GO:0006586)4.41957015
61glycine metabolic process (GO:0006544)4.39084869
62benzene-containing compound metabolic process (GO:0042537)4.32723414
63cellular amino acid catabolic process (GO:0009063)4.31924564
64amine catabolic process (GO:0009310)4.31043765
65cellular biogenic amine catabolic process (GO:0042402)4.31043765
66imidazole-containing compound metabolic process (GO:0052803)4.27983279
67glutamate metabolic process (GO:0006536)4.26639530
68cellular ketone body metabolic process (GO:0046950)4.23927789
69phospholipid efflux (GO:0033700)4.22300273
70xenobiotic catabolic process (GO:0042178)4.19079585
71serine family amino acid metabolic process (GO:0009069)4.18347994
72aldehyde catabolic process (GO:0046185)4.14506027
73cellular modified amino acid catabolic process (GO:0042219)4.13038687
74plasma lipoprotein particle clearance (GO:0034381)4.12971094
75* drug metabolic process (GO:0017144)4.08177246
76ethanol oxidation (GO:0006069)4.07764024
77arginine metabolic process (GO:0006525)4.03630949
78cholesterol efflux (GO:0033344)4.01448087
79serine family amino acid biosynthetic process (GO:0009070)4.01327237
80dicarboxylic acid biosynthetic process (GO:0043650)4.00882272
81fibrinolysis (GO:0042730)3.93254210
82cofactor catabolic process (GO:0051187)3.91613025
83regulation of bile acid biosynthetic process (GO:0070857)3.89654356
84blood coagulation, intrinsic pathway (GO:0007597)3.81425609
85disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.80055392
86killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.80055392
87low-density lipoprotein particle remodeling (GO:0034374)3.76901097
88negative regulation of lipase activity (GO:0060192)3.76598441
89organic acid catabolic process (GO:0016054)3.75642162
90carboxylic acid catabolic process (GO:0046395)3.75642162
91* omega-hydroxylase P450 pathway (GO:0097267)3.74792274
92complement activation, classical pathway (GO:0006958)3.73031707
93plasma lipoprotein particle assembly (GO:0034377)3.71491408
94opsonization (GO:0008228)3.71419840
95short-chain fatty acid metabolic process (GO:0046459)3.71399398
96complement activation (GO:0006956)3.70121584
97protein activation cascade (GO:0072376)3.67509445
98ketone body metabolic process (GO:1902224)3.66434904
99cholesterol homeostasis (GO:0042632)3.66234918
100acetyl-CoA metabolic process (GO:0006084)3.66052924
101cytolysis (GO:0019835)3.65813661
102phenylpropanoid metabolic process (GO:0009698)3.65316832
103positive regulation of lipid catabolic process (GO:0050996)3.65050927
104water-soluble vitamin biosynthetic process (GO:0042364)3.63461160
105L-methionine salvage (GO:0071267)3.63232563
106L-methionine biosynthetic process (GO:0071265)3.63232563
107amino acid salvage (GO:0043102)3.63232563
108response to nitrosative stress (GO:0051409)3.61344157
109sterol homeostasis (GO:0055092)3.60191795
110phospholipid homeostasis (GO:0055091)3.58416367
111sodium-independent organic anion transport (GO:0043252)3.57328642
112regulation of plasminogen activation (GO:0010755)3.56922910
113regulation of cholesterol homeostasis (GO:2000188)3.54249408
114aspartate family amino acid catabolic process (GO:0009068)3.53644266
115pyrimidine nucleobase catabolic process (GO:0006208)3.51704991
116behavioral response to nicotine (GO:0035095)3.38423840
117heme transport (GO:0015886)3.35662979
118negative regulation of protein activation cascade (GO:2000258)3.35484182
119regulation of hexokinase activity (GO:1903299)3.32210229
120regulation of glucokinase activity (GO:0033131)3.32210229
121intestinal cholesterol absorption (GO:0030299)3.25011006
122* xenobiotic metabolic process (GO:0006805)3.22961050
123positive regulation of fatty acid transport (GO:2000193)3.21003430
124negative regulation of hemostasis (GO:1900047)3.19167310
125negative regulation of blood coagulation (GO:0030195)3.19167310
126nucleobase catabolic process (GO:0046113)3.18342364
127regulation of humoral immune response (GO:0002920)3.16174800
128urate metabolic process (GO:0046415)3.15356241
129positive regulation of icosanoid secretion (GO:0032305)3.14298701

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.37823405
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.12476728
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.05907666
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.48258320
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.30023065
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.04987216
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74611238
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05471545
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.95466792
10ZNF274_21170338_ChIP-Seq_K562_Hela2.93690585
11VDR_22108803_ChIP-Seq_LS180_Human2.63167383
12GBX2_23144817_ChIP-Seq_PC3_Human2.45670100
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36576385
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10064921
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09147035
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9595866
17IGF1R_20145208_ChIP-Seq_DFB_Human1.94538663
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.94533921
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93523493
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91563921
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91488440
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91139920
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85242883
24ER_23166858_ChIP-Seq_MCF-7_Human1.84622384
25P300_19829295_ChIP-Seq_ESCs_Human1.67176042
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.65680170
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.57675709
28HTT_18923047_ChIP-ChIP_STHdh_Human1.57364319
29FUS_26573619_Chip-Seq_HEK293_Human1.56924792
30CLOCK_20551151_ChIP-Seq_293T_Human1.56648196
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55553062
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55004328
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52003851
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.51909312
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51497396
36EZH2_22144423_ChIP-Seq_EOC_Human1.48767549
37GATA1_22025678_ChIP-Seq_K562_Human1.48242495
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45881848
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45043904
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44722019
41CBP_20019798_ChIP-Seq_JUKART_Human1.42296837
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42296837
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.40387125
44HNF4A_19822575_ChIP-Seq_HepG2_Human1.38777247
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37723626
46EWS_26573619_Chip-Seq_HEK293_Human1.36273603
47STAT3_23295773_ChIP-Seq_U87_Human1.35561956
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34720252
49NANOG_19829295_ChIP-Seq_ESCs_Human1.34044152
50SOX2_19829295_ChIP-Seq_ESCs_Human1.34044152
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31711222
52TCF4_23295773_ChIP-Seq_U87_Human1.30854440
53* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30227871
54* FOXA1_25329375_ChIP-Seq_VCAP_Human1.30227871
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27145624
56AR_25329375_ChIP-Seq_VCAP_Human1.26178950
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25691124
58TCF4_22108803_ChIP-Seq_LS180_Human1.25122286
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.22717654
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22403693
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22363725
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21776087
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21750798
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21313859
65TP53_22573176_ChIP-Seq_HFKS_Human1.20845490
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20353375
67SMAD4_21799915_ChIP-Seq_A2780_Human1.19922799
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18317061
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.18155731
70RUNX2_22187159_ChIP-Seq_PCA_Human1.17836538
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17131018
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17079667
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16895137
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.16459225
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15050296
76RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14789555
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13097795
78CDX2_22108803_ChIP-Seq_LS180_Human1.12708564
79* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12499807
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11892641
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09683018
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09683018
83MYC_19829295_ChIP-Seq_ESCs_Human1.09159851
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.08470381
85PHF8_20622853_ChIP-Seq_HELA_Human1.08076791
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08025384
87ETV1_20927104_ChIP-Seq_GIST48_Human1.05503188
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05500469
89* REST_21632747_ChIP-Seq_MESCs_Mouse1.05160426
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04118554
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.02449104
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02004961
93P53_22387025_ChIP-Seq_ESCs_Mouse1.00439271
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.99851372
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98380149
96OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98246870
97NFYA_21822215_ChIP-Seq_K562_Human0.97853533
98* FOXH1_21741376_ChIP-Seq_EPCs_Human0.97569276
99MYC_18940864_ChIP-ChIP_HL60_Human0.97542898
100HOXB7_26014856_ChIP-Seq_BT474_Human0.97237054
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93858390
102SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93055886
103AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87162315
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86548869
105RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81341792
106ESR2_21235772_ChIP-Seq_MCF-7_Human0.80436359
107GATA4_25053715_ChIP-Seq_YYC3_Human0.80144602
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79574826
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79224979
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77223420
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73697206
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.73199892
113IRF8_22096565_ChIP-ChIP_GC-B_Human0.72955167
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72571819
115RARA_24833708_ChIP-Seq_LIVER_Mouse0.72281333
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71263152
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70614578
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70614578
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70080080
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69841076
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.69524525
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69410717
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67341070
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66985800
125RARB_24833708_ChIP-Seq_LIVER_Mouse0.63042169
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62410485
127ZNF263_19887448_ChIP-Seq_K562_Human0.61875531
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61540452
129ESR1_21235772_ChIP-Seq_MCF-7_Human0.60987822
130EGR1_19032775_ChIP-ChIP_M12_Human0.60202822
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60168695
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58683872
133CEBPB_22108803_ChIP-Seq_LS180_Human0.56502927
134IRF1_19129219_ChIP-ChIP_H3396_Human0.54588807
135MYC_19915707_ChIP-ChIP_AK7_Human0.52864751
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52576178
137LXR_22292898_ChIP-Seq_THP-1_Human0.52462177
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.51777676
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.51201514
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50384963
141CBP_21632823_ChIP-Seq_H3396_Human0.49578033
142ESET_19884257_ChIP-Seq_ESCs_Mouse0.49139929
143* AR_20517297_ChIP-Seq_VCAP_Human0.49007120
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48843969
145TAF15_26573619_Chip-Seq_HEK293_Human0.48370965
146STAT1_17558387_ChIP-Seq_HELA_Human0.47970347
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.47079002
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.46943224
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.46483045
150P53_21459846_ChIP-Seq_SAOS-2_Human0.46072607
151PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43607401
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43127877
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41228786
154ESR1_20079471_ChIP-ChIP_T-47D_Human0.40665705
155PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.40552817
156GATA1_19941826_ChIP-Seq_K562_Human0.40454982
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39633795
158BCAT_22108803_ChIP-Seq_LS180_Human0.39622074
159SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39608024
160GATA1_19941827_ChIP-Seq_MEL_Mouse0.39554445
161GATA6_25053715_ChIP-Seq_YYC3_Human0.39015733
162FOXO3_23340844_ChIP-Seq_DLD1_Human0.38479065
163GATA2_19941826_ChIP-Seq_K562_Human0.38184038
164SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37122428
165TAF2_19829295_ChIP-Seq_ESCs_Human0.36829574
166MYC_27129775_Chip-Seq_CORNEA_Mouse0.36809683
167PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36482050
168LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36074286
169NCOR_22424771_ChIP-Seq_293T_Human0.35924032
170SPI1_26923725_Chip-Seq_HPCs_Mouse0.35184390
171STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.34407739
172GATA3_24758297_ChIP-Seq_MCF-7_Human0.33971900
173OCT4_20526341_ChIP-Seq_ESCs_Human0.33682468
174ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.33440559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.35309275
2MP0005360_urolithiasis7.51511099
3MP0005085_abnormal_gallbladder_physiolo6.49755499
4MP0005365_abnormal_bile_salt6.15621385
5* MP0008875_abnormal_xenobiotic_pharmacok5.98083944
6MP0003806_abnormal_nucleotide_metabolis4.24003793
7MP0003252_abnormal_bile_duct3.91268072
8MP0010329_abnormal_lipoprotein_level3.50778501
9MP0009840_abnormal_foam_cell3.04182953
10MP0005083_abnormal_biliary_tract2.96612693
11MP0003195_calcinosis2.84369466
12MP0005332_abnormal_amino_acid2.74912150
13MP0001666_abnormal_nutrient_absorption2.56891906
14MP0004019_abnormal_vitamin_homeostasis2.14567827
15* MP0000609_abnormal_liver_physiology2.11641034
16MP0002118_abnormal_lipid_homeostasis2.06073288
17MP0003191_abnormal_cellular_cholesterol1.99325510
18MP0003868_abnormal_feces_composition1.92588774
19MP0002138_abnormal_hepatobiliary_system1.89524862
20* MP0005319_abnormal_enzyme/_coenzyme1.85015418
21MP0001764_abnormal_homeostasis1.69263345
22MP0006292_abnormal_olfactory_placode1.63014820
23MP0005584_abnormal_enzyme/coenzyme_acti1.59585071
24MP0005551_abnormal_eye_electrophysiolog1.58279608
25MP0009697_abnormal_copulation1.51543839
26MP0008877_abnormal_DNA_methylation1.41169995
27MP0001986_abnormal_taste_sensitivity1.40375569
28MP0005451_abnormal_body_composition1.35964490
29MP0003011_delayed_dark_adaptation1.35500706
30MP0002234_abnormal_pharynx_morphology1.33789028
31MP0003656_abnormal_erythrocyte_physiolo1.32859538
32MP0005646_abnormal_pituitary_gland1.30971246
33MP0004142_abnormal_muscle_tone1.30779764
34MP0003186_abnormal_redox_activity1.30374968
35MP0009643_abnormal_urine_homeostasis1.23235890
36MP0009764_decreased_sensitivity_to1.20244927
37MP0002102_abnormal_ear_morphology1.19981568
38* MP0000598_abnormal_liver_morphology1.16737296
39MP0003136_yellow_coat_color1.12512897
40MP0003705_abnormal_hypodermis_morpholog1.11940443
41MP0005647_abnormal_sex_gland1.10225839
42MP0001968_abnormal_touch/_nociception1.02312784
43MP0004133_heterotaxia0.99897081
44MP0000604_amyloidosis0.99604715
45MP0009763_increased_sensitivity_to0.99469351
46* MP0009745_abnormal_behavioral_response0.99462641
47MP0002254_reproductive_system_inflammat0.98141666
48MP0003646_muscle_fatigue0.96231866
49MP0004043_abnormal_pH_regulation0.96097869
50MP0002638_abnormal_pupillary_reflex0.94700588
51MP0010368_abnormal_lymphatic_system0.94529508
52MP0002736_abnormal_nociception_after0.92507441
53MP0009765_abnormal_xenobiotic_induced0.90722878
54MP0005408_hypopigmentation0.89138434
55MP0003787_abnormal_imprinting0.87912881
56MP0005636_abnormal_mineral_homeostasis0.87134891
57MP0002282_abnormal_trachea_morphology0.86786267
58MP0005670_abnormal_white_adipose0.86658514
59* MP0008469_abnormal_protein_level0.86048568
60* MP0009642_abnormal_blood_homeostasis0.85018335
61MP0000372_irregular_coat_pigmentation0.84009921
62MP0006036_abnormal_mitochondrial_physio0.83262903
63MP0005376_homeostasis/metabolism_phenot0.81200384
64MP0005187_abnormal_penis_morphology0.81197421
65MP0004885_abnormal_endolymph0.79015073
66MP0001501_abnormal_sleep_pattern0.78175927
67MP0005645_abnormal_hypothalamus_physiol0.76204666
68MP0002272_abnormal_nervous_system0.75805762
69MP0002078_abnormal_glucose_homeostasis0.75352065
70MP0001485_abnormal_pinna_reflex0.73121572
71MP0005084_abnormal_gallbladder_morpholo0.73008738
72MP0002876_abnormal_thyroid_physiology0.72945873
73MP0005253_abnormal_eye_physiology0.72584600
74MP0005266_abnormal_metabolism0.70829935
75MP0001984_abnormal_olfaction0.70613140
76MP0003880_abnormal_central_pattern0.69997891
77MP0002653_abnormal_ependyma_morphology0.69057350
78MP0003690_abnormal_glial_cell0.69028365
79MP0000631_abnormal_neuroendocrine_gland0.68288232
80MP0004130_abnormal_muscle_cell0.68169382
81MP0006072_abnormal_retinal_apoptosis0.67960345
82MP0000427_abnormal_hair_cycle0.67699084
83MP0005220_abnormal_exocrine_pancreas0.67298395
84MP0009046_muscle_twitch0.66318256
85MP0009053_abnormal_anal_canal0.65414928
86MP0005334_abnormal_fat_pad0.64962892
87MP0002971_abnormal_brown_adipose0.64822779
88MP0002938_white_spotting0.63923464
89MP0005379_endocrine/exocrine_gland_phen0.63736409
90MP0003878_abnormal_ear_physiology0.63318836
91MP0005377_hearing/vestibular/ear_phenot0.63318836
92MP0003329_amyloid_beta_deposits0.61448197
93MP0000569_abnormal_digit_pigmentation0.60973644
94* MP0005535_abnormal_body_temperature0.60780224
95MP0002735_abnormal_chemical_nociception0.60600611
96MP0006276_abnormal_autonomic_nervous0.60565532
97MP0005386_behavior/neurological_phenoty0.59589931
98MP0004924_abnormal_behavior0.59589931
99MP0002064_seizures0.59544744
100MP0003879_abnormal_hair_cell0.58861320
101MP0005195_abnormal_posterior_eye0.58573708
102MP0001486_abnormal_startle_reflex0.58176804
103* MP0008874_decreased_physiological_sensi0.57840123
104MP0000639_abnormal_adrenal_gland0.57230450
105MP0001661_extended_life_span0.56438810
106MP0002822_catalepsy0.56262685
107MP0006035_abnormal_mitochondrial_morpho0.56192002
108MP0001756_abnormal_urination0.56139061
109MP0008873_increased_physiological_sensi0.56041862
110MP0001440_abnormal_grooming_behavior0.55554459
111MP0004147_increased_porphyrin_level0.55526381
112MP0001502_abnormal_circadian_rhythm0.54692113
113* MP0008872_abnormal_physiological_respon0.51765540
114MP0005448_abnormal_energy_balance0.50546543
115MP0003638_abnormal_response/metabolism_0.47482404
116MP0005464_abnormal_platelet_physiology0.45868414
117MP0003718_maternal_effect0.45299913
118MP0002928_abnormal_bile_duct0.44493768
119MP0005395_other_phenotype0.44230072
120MP0002837_dystrophic_cardiac_calcinosis0.43386241
121MP0003075_altered_response_to0.43059897
122MP0002136_abnormal_kidney_physiology0.42175028
123MP0005248_abnormal_Harderian_gland0.41906227
124MP0004381_abnormal_hair_follicle0.39335738
125MP0003436_decreased_susceptibility_to0.38923699
126MP0009672_abnormal_birth_weight0.38796769
127MP0003953_abnormal_hormone_level0.38263176
128MP0005166_decreased_susceptibility_to0.36241059
129MP0005666_abnormal_adipose_tissue0.36108152
130MP0000579_abnormal_nail_morphology0.35656635
131MP0003724_increased_susceptibility_to0.34020511
132MP0002090_abnormal_vision0.31188598
133MP0009384_cardiac_valve_regurgitation0.31073684
134MP0002796_impaired_skin_barrier0.30118100
135MP0009115_abnormal_fat_cell0.29636055
136MP0006082_CNS_inflammation0.29619350
137MP0000249_abnormal_blood_vessel0.29464467
138MP0001243_abnormal_dermal_layer0.28812817
139MP0000230_abnormal_systemic_arterial0.28676822
140MP0002970_abnormal_white_adipose0.27398523
141MP0002168_other_aberrant_phenotype0.27130595
142MP0001881_abnormal_mammary_gland0.26820650
143MP0002132_abnormal_respiratory_system0.25473323
144MP0001853_heart_inflammation0.24879304
145MP0001845_abnormal_inflammatory_respons0.24441209
146MP0002060_abnormal_skin_morphology0.24204660
147MP0004883_abnormal_blood_vessel0.23488727
148MP0005058_abnormal_lysosome_morphology0.23139548
149MP0002135_abnormal_kidney_morphology0.20571988

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.58604733
2Deep venous thrombosis (HP:0002625)7.51527763
3Intrahepatic cholestasis (HP:0001406)7.34883921
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.80186021
5Prolonged partial thromboplastin time (HP:0003645)6.68527102
6Hypobetalipoproteinemia (HP:0003563)6.45928757
7Xanthomatosis (HP:0000991)6.18108581
8Hyperlipoproteinemia (HP:0010980)5.76440523
9Complement deficiency (HP:0004431)5.35433633
10Joint hemorrhage (HP:0005261)4.79996725
11Hypolipoproteinemia (HP:0010981)4.74511353
12Hyperammonemia (HP:0001987)4.61856868
13Epidermoid cyst (HP:0200040)4.57913746
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.37231021
15Hyperglycinemia (HP:0002154)4.34415846
16Abnormality of methionine metabolism (HP:0010901)4.33398630
17Ketosis (HP:0001946)4.32276338
18Abnormality of the common coagulation pathway (HP:0010990)4.32192896
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.27170095
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.23973462
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13927124
22Fat malabsorption (HP:0002630)4.10049171
23Hypoalphalipoproteinemia (HP:0003233)4.09142131
24Hyperglycinuria (HP:0003108)4.03609113
25Abnormality of serine family amino acid metabolism (HP:0010894)3.97404913
26Abnormality of glycine metabolism (HP:0010895)3.97404913
27Abnormality of pyrimidine metabolism (HP:0004353)3.94152617
28Abnormality of complement system (HP:0005339)3.90368503
29Abnormality of the intrinsic pathway (HP:0010989)3.85231839
30Conjugated hyperbilirubinemia (HP:0002908)3.78239343
31Hypoglycemic coma (HP:0001325)3.72658178
32Fair hair (HP:0002286)3.62076706
33Hypercholesterolemia (HP:0003124)3.61021724
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37899474
35Hyperbilirubinemia (HP:0002904)3.37781970
36Abnormality of fatty-acid metabolism (HP:0004359)3.31752971
37Delayed CNS myelination (HP:0002188)3.19948612
38Steatorrhea (HP:0002570)3.16974245
39Abnormality of nucleobase metabolism (HP:0010932)3.10129762
40Abnormality of serum amino acid levels (HP:0003112)3.04262825
41Pancreatic cysts (HP:0001737)3.02692184
42Hepatocellular carcinoma (HP:0001402)2.98975374
43Ketoacidosis (HP:0001993)2.95825161
44Myocardial infarction (HP:0001658)2.94018500
45Hypochromic microcytic anemia (HP:0004840)2.91780974
46Pancreatic fibrosis (HP:0100732)2.89007717
47Skin nodule (HP:0200036)2.88455674
48Chronic hepatic failure (HP:0100626)2.86158789
49Spontaneous abortion (HP:0005268)2.78658344
50Metabolic acidosis (HP:0001942)2.77112715
51Systemic lupus erythematosus (HP:0002725)2.76819305
52Abnormal biliary tract physiology (HP:0012439)2.75675011
53Bile duct proliferation (HP:0001408)2.75675011
54True hermaphroditism (HP:0010459)2.69518080
55Neonatal hypoglycemia (HP:0001998)2.69380465
56Generalized hypopigmentation of hair (HP:0011358)2.68909905
57Abnormality of purine metabolism (HP:0004352)2.68118334
58Lethargy (HP:0001254)2.63056644
59Abnormality of midbrain morphology (HP:0002418)2.61622029
60Molar tooth sign on MRI (HP:0002419)2.61622029
61Congenital stationary night blindness (HP:0007642)2.58195286
62Spastic diplegia (HP:0001264)2.57774343
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55921300
64Dicarboxylic aciduria (HP:0003215)2.55921300
65Vascular calcification (HP:0004934)2.49383177
66Abnormal gallbladder morphology (HP:0012437)2.48198219
67Abnormality of the renal cortex (HP:0011035)2.46605761
68Gout (HP:0001997)2.45065285
69Cerebral edema (HP:0002181)2.43903785
70Mitral stenosis (HP:0001718)2.42552205
71Recurrent gram-negative bacterial infections (HP:0005420)2.41976903
72Neonatal onset (HP:0003623)2.41766972
73Decreased central vision (HP:0007663)2.41139033
74Cholelithiasis (HP:0001081)2.40749658
75Irritability (HP:0000737)2.39041771
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38993536
77Abnormality of alanine metabolism (HP:0010916)2.38993536
78Hyperalaninemia (HP:0003348)2.38993536
79Acanthocytosis (HP:0001927)2.37734594
80Glomerulonephritis (HP:0000099)2.37391304
81Hypoglycemic seizures (HP:0002173)2.34149685
82Hyperventilation (HP:0002883)2.29650752
83Brushfield spots (HP:0001088)2.21914544
84Cardiovascular calcification (HP:0011915)2.21166082
85Abnormal gallbladder physiology (HP:0012438)2.19825123
86Cholecystitis (HP:0001082)2.19825123
87Type II lissencephaly (HP:0007260)2.19172730
88Nephronophthisis (HP:0000090)2.17241029
89Esophageal varix (HP:0002040)2.15006458
90Malnutrition (HP:0004395)2.14937463
91Arthropathy (HP:0003040)2.12679390
92Sensorimotor neuropathy (HP:0007141)2.11901021
93Glycosuria (HP:0003076)2.11396783
94Abnormality of urine glucose concentration (HP:0011016)2.11396783
95Menorrhagia (HP:0000132)2.10742072
96Amyloidosis (HP:0011034)2.10055459
97Enlarged kidneys (HP:0000105)2.09220037
98Pendular nystagmus (HP:0012043)2.08982408
99Opisthotonus (HP:0002179)2.08710481
100Cystic liver disease (HP:0006706)2.08273929
101Gingival bleeding (HP:0000225)2.06264122
102Abolished electroretinogram (ERG) (HP:0000550)2.05750540
103Pancreatitis (HP:0001733)2.05632282
104Vomiting (HP:0002013)2.05132535
105Attenuation of retinal blood vessels (HP:0007843)2.02709087
106Abnormality of the gallbladder (HP:0005264)1.99815754
107Generalized aminoaciduria (HP:0002909)1.99456266
108Thrombophlebitis (HP:0004418)1.98715996
109Poikilocytosis (HP:0004447)1.98352213
110Abnormality of proline metabolism (HP:0010907)1.97635539
111Hydroxyprolinuria (HP:0003080)1.97635539
112Abnormal cartilage morphology (HP:0002763)1.97344917
113Late onset (HP:0003584)1.96439501
114Status epilepticus (HP:0002133)1.95793901
115Hemorrhage of the eye (HP:0011885)1.95469480
116Rickets (HP:0002748)1.93751872
117Abnormality of the renal medulla (HP:0100957)1.93720327
118Methylmalonic acidemia (HP:0002912)1.92781852
119Abnormal rod and cone electroretinograms (HP:0008323)1.92147772
120Hyperinsulinemic hypoglycemia (HP:0000825)1.91893824
121Hypophosphatemic rickets (HP:0004912)1.88826380
122Blue irides (HP:0000635)1.86784058
123Abnormal enzyme/coenzyme activity (HP:0012379)1.86729917
124Renal cortical cysts (HP:0000803)1.86597458
125Abnormality of iron homeostasis (HP:0011031)1.84980395
126Hypochromic anemia (HP:0001931)1.84652468
127Abnormality of transition element cation homeostasis (HP:0011030)1.82583572
128Alkalosis (HP:0001948)1.80432880
129Abnormality of vitamin metabolism (HP:0100508)1.79353700
130Hyperphosphaturia (HP:0003109)1.78591851
131Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77513704
132Elevated hepatic transaminases (HP:0002910)1.76753443
133Medial flaring of the eyebrow (HP:0010747)1.75313355
134Hypothermia (HP:0002045)1.74161441
135Hyperglycemia (HP:0003074)1.74072669
136Nephritis (HP:0000123)1.72492874
137Acute encephalopathy (HP:0006846)1.72247751
138Keratoconus (HP:0000563)1.70264026
139Increased corneal curvature (HP:0100692)1.70264026
140Tubular atrophy (HP:0000092)1.68486179
141Inability to walk (HP:0002540)1.63148328
142Male pseudohermaphroditism (HP:0000037)1.62337671
143Congenital hepatic fibrosis (HP:0002612)1.61127567
1443-Methylglutaconic aciduria (HP:0003535)1.60008621
145Methylmalonic aciduria (HP:0012120)1.59224206
146Cerebral palsy (HP:0100021)1.58023859
147Dyskinesia (HP:0100660)1.55465387
148Sclerocornea (HP:0000647)1.53738733
149Large for gestational age (HP:0001520)1.52265059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.10183856
2FGFR44.59724627
3ERN14.34033949
4SIK14.21235238
5TLK13.74330586
6ADRBK23.15513064
7INSRR3.13469089
8ERBB43.00226734
9MAP4K22.85453231
10TAOK32.84678237
11WNK32.74335149
12BMPR1B2.70659760
13MAP2K42.59391178
14NUAK12.55769858
15ZAK2.23801871
16PKN22.23606444
17MST1R2.14818843
18ACVR1B2.09256137
19WNK41.89384492
20MAPK111.86789609
21LATS11.85384654
22FLT31.84486838
23OXSR11.79327788
24CASK1.70130904
25TRIB31.69411715
26TNIK1.66908605
27TYK21.65247743
28ABL21.57915216
29CAMKK21.56932189
30FGFR21.56120257
31MAPK131.52969841
32FRK1.50346545
33PIK3CG1.49001655
34DAPK21.44894369
35PTK61.41624764
36TXK1.39353194
37TRIM281.34949455
38GRK61.32762429
39NEK91.30848826
40MAP3K71.26530798
41MAP3K41.26392035
42JAK21.23980669
43KDR1.19185954
44NTRK31.13278610
45MAP2K31.12411561
46STK391.11934279
47PINK11.10894327
48PRKAA21.09107256
49ADRBK11.07195690
50ERBB21.06714444
51MAP3K141.06498240
52MAPK41.04798646
53TNK21.04538264
54DYRK21.02692577
55JAK10.99501741
56TBK10.98867527
57PRKCZ0.97586415
58MAP3K30.95429272
59MAPK150.94880779
60PRKCE0.92552183
61MAPK120.90777658
62MAP3K100.90506007
63STK160.88645861
64MET0.87049938
65STK38L0.85596029
66MARK10.82133379
67KIT0.80528131
68EPHB10.79924551
69PRKACG0.77891308
70MAP2K60.77737909
71CDK60.77522474
72IKBKB0.77378021
73CAMK2G0.76094709
74MAP3K110.75577591
75TGFBR10.74170478
76MUSK0.73816916
77MKNK20.73790685
78MAP2K70.73596266
79CSK0.72844221
80TEC0.70943913
81VRK10.70616634
82MST40.70227815
83MAPK70.69618842
84TIE10.68962393
85DYRK1B0.67888986
86FGFR30.67781635
87TAOK20.67559022
88MAPKAPK30.66501759
89SGK30.66426347
90BRSK20.66158510
91PRKACA0.65853645
92EPHA30.65508715
93PHKG20.65349000
94PHKG10.65349000
95TGFBR20.63135332
96GSK3A0.63059710
97EPHA40.62663856
98CSF1R0.61350152
99PRKAA10.60132048
100PLK20.59613327
101PNCK0.58343267
102PRKG10.57422911
103PTK20.55730990
104RIPK10.55580047
105GRK70.54868727
106IKBKE0.52722099
107FER0.52450946
108STK110.51679621
109PDPK10.51677751
110CSNK1G10.50728446
111PRKCQ0.50450205
112IGF1R0.50422749
113IRAK10.50150620
114NLK0.49994480
115GRK10.49665507
116NTRK20.49268074
117PTK2B0.49236787
118MAP3K50.48992208
119PRKCG0.47730008
120SGK20.47365594
121RET0.47222326
122CSNK1A10.46603481
123CSNK1D0.45591037
124ERBB30.45329819
125CDK190.44583297
126CAMK2A0.42729786
127CHUK0.42709397
128MAP2K10.41607554
129BCR0.40839634
130PKN10.40590448
131EIF2AK30.39910181
132PRKCI0.39365418
133MAP3K60.39347190
134LATS20.39336397
135IRAK30.39096276
136CSNK1G20.38606078
137CAMK1D0.38360000
138CAMK10.38166236
139AKT30.37996974
140EGFR0.37657344
141RPS6KA50.37366064
142MAP3K130.36809580
143PLK40.36692109
144ICK0.36136449
145SGK4940.35994310
146SGK2230.35994310
147STK30.35603270
148PDK20.35367618
149PRKCA0.34072352
150PDK30.33916602
151PDK40.33916602
152PAK30.33868350
153PRKACB0.33783984
154CDK40.33406905
155DYRK1A0.33382090
156PDK10.33298273
157ITK0.32831966
158CAMK40.31652124
159CSNK1G30.30792952
160MTOR0.30251658
161PIK3CA0.29034216
162ABL10.25229465
163BMX0.24844363
164PBK0.24792422
165CSNK1A1L0.22948947
166MAP3K10.22863195

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54666453
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.60518156
3Nitrogen metabolism_Homo sapiens_hsa009103.49878824
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44911704
5Arginine biosynthesis_Homo sapiens_hsa002203.06921043
6* Tryptophan metabolism_Homo sapiens_hsa003802.84187588
7Complement and coagulation cascades_Homo sapiens_hsa046102.67622013
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51476630
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49323845
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.48011380
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47501217
12Fatty acid degradation_Homo sapiens_hsa000712.38115144
13* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.36798294
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34517548
15* Steroid hormone biosynthesis_Homo sapiens_hsa001402.28796314
16* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.26574789
17* Chemical carcinogenesis_Homo sapiens_hsa052042.23965355
18Butanoate metabolism_Homo sapiens_hsa006502.09437524
19Peroxisome_Homo sapiens_hsa041462.02112382
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.92780902
21* Retinol metabolism_Homo sapiens_hsa008301.90266426
22Histidine metabolism_Homo sapiens_hsa003401.90143850
23Propanoate metabolism_Homo sapiens_hsa006401.83288039
24PPAR signaling pathway_Homo sapiens_hsa033201.77674816
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75900824
26beta-Alanine metabolism_Homo sapiens_hsa004101.70304047
27Staphylococcus aureus infection_Homo sapiens_hsa051501.68202006
28Fatty acid metabolism_Homo sapiens_hsa012121.64395961
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64175791
30Selenocompound metabolism_Homo sapiens_hsa004501.60369704
31Phenylalanine metabolism_Homo sapiens_hsa003601.58597963
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54861054
33Bile secretion_Homo sapiens_hsa049761.53917701
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48437101
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45091862
36Tyrosine metabolism_Homo sapiens_hsa003501.41407387
37Sulfur metabolism_Homo sapiens_hsa009201.38911774
38Starch and sucrose metabolism_Homo sapiens_hsa005001.35519103
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.31793258
40Pyruvate metabolism_Homo sapiens_hsa006201.30179799
41* Caffeine metabolism_Homo sapiens_hsa002321.21004276
42Fatty acid elongation_Homo sapiens_hsa000621.20938866
43ABC transporters_Homo sapiens_hsa020101.20904002
44Biosynthesis of amino acids_Homo sapiens_hsa012301.19290125
45Folate biosynthesis_Homo sapiens_hsa007901.17263792
46Steroid biosynthesis_Homo sapiens_hsa001001.16161951
47Carbon metabolism_Homo sapiens_hsa012001.08210216
48Fat digestion and absorption_Homo sapiens_hsa049751.06073287
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04380401
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99879758
51Arginine and proline metabolism_Homo sapiens_hsa003300.98059301
52Sulfur relay system_Homo sapiens_hsa041220.96461707
53Vitamin B6 metabolism_Homo sapiens_hsa007500.94128992
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.92714767
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.90099437
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84632130
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80747543
58Lysine degradation_Homo sapiens_hsa003100.77807990
59Glutathione metabolism_Homo sapiens_hsa004800.75735197
60Phototransduction_Homo sapiens_hsa047440.75357915
61One carbon pool by folate_Homo sapiens_hsa006700.74416921
62Vitamin digestion and absorption_Homo sapiens_hsa049770.73774503
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68072695
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65511939
65Glycerolipid metabolism_Homo sapiens_hsa005610.64261819
66Pentose phosphate pathway_Homo sapiens_hsa000300.55470425
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55365083
68Oxidative phosphorylation_Homo sapiens_hsa001900.50589808
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49733493
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49115938
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47581710
72* Metabolic pathways_Homo sapiens_hsa011000.45561284
73Fatty acid biosynthesis_Homo sapiens_hsa000610.43737621
74Protein export_Homo sapiens_hsa030600.41922440
75Nicotine addiction_Homo sapiens_hsa050330.35869734
76Prion diseases_Homo sapiens_hsa050200.35570154
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30990152
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30946273
79Homologous recombination_Homo sapiens_hsa034400.26900032
80Serotonergic synapse_Homo sapiens_hsa047260.26828865
81Mineral absorption_Homo sapiens_hsa049780.22789479
82Parkinsons disease_Homo sapiens_hsa050120.22776068
83Fructose and mannose metabolism_Homo sapiens_hsa000510.21969939
84Galactose metabolism_Homo sapiens_hsa000520.21832205
85Insulin resistance_Homo sapiens_hsa049310.20895694
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.18378656
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17478196
88RNA polymerase_Homo sapiens_hsa030200.16851906
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.14237186
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13361488
91Ovarian steroidogenesis_Homo sapiens_hsa049130.13040788
92Basal transcription factors_Homo sapiens_hsa030220.12373092
93Fanconi anemia pathway_Homo sapiens_hsa034600.09905522
94Taste transduction_Homo sapiens_hsa047420.09493808
95GABAergic synapse_Homo sapiens_hsa047270.09376554
96Glucagon signaling pathway_Homo sapiens_hsa049220.08295356
97Olfactory transduction_Homo sapiens_hsa047400.07335214
98Circadian rhythm_Homo sapiens_hsa047100.05415337
99* Linoleic acid metabolism_Homo sapiens_hsa005910.04549721
100Non-homologous end-joining_Homo sapiens_hsa034500.02218129
101Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2371936
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2353514
103Amoebiasis_Homo sapiens_hsa05146-0.2308041
104Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2158541
105Ether lipid metabolism_Homo sapiens_hsa00565-0.2154043
106Renin-angiotensin system_Homo sapiens_hsa04614-0.2153098
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2120547
108Hepatitis C_Homo sapiens_hsa05160-0.2023858
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1963475
110Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1753553
111Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1675283
112Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1667172
113African trypanosomiasis_Homo sapiens_hsa05143-0.1640603
114Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1598956
115Regulation of autophagy_Homo sapiens_hsa04140-0.1512110
116Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1473460
117Insulin signaling pathway_Homo sapiens_hsa04910-0.1270842
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1206111
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1007897
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0615168
121Insulin secretion_Homo sapiens_hsa04911-0.0049605
122AMPK signaling pathway_Homo sapiens_hsa04152-0.0008595

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »