CYP1B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)6.47602135
2protein heterotrimerization (GO:0070208)6.40205735
3* collagen fibril organization (GO:0030199)6.39856806
4skin morphogenesis (GO:0043589)5.34343925
5endodermal cell differentiation (GO:0035987)5.32973520
6sequestering of extracellular ligand from receptor (GO:0035581)5.31036101
7cell adhesion mediated by integrin (GO:0033627)5.10691213
8response to peptidoglycan (GO:0032494)5.08265896
9regulation of mononuclear cell migration (GO:0071675)5.06188021
10negative regulation of interleukin-12 production (GO:0032695)5.01019383
11regulation of vitamin D biosynthetic process (GO:0060556)4.89718175
12bone trabecula formation (GO:0060346)4.80920903
13positive regulation of endothelial cell apoptotic process (GO:2000353)4.71671320
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.68444029
15glycosphingolipid catabolic process (GO:0046479)4.43182384
16negative regulation of fatty acid transport (GO:2000192)4.34676006
17cellular response to thyroid hormone stimulus (GO:0097067)4.21565680
18neuron projection extension involved in neuron projection guidance (GO:1902284)4.16632487
19axon extension involved in axon guidance (GO:0048846)4.16632487
20lipopolysaccharide-mediated signaling pathway (GO:0031663)4.14924660
21collagen metabolic process (GO:0032963)4.13079784
22oligosaccharide catabolic process (GO:0009313)4.12209078
23negative regulation of chondrocyte differentiation (GO:0032331)4.08302588
24collagen catabolic process (GO:0030574)4.04518790
25mesenchymal-epithelial cell signaling (GO:0060638)4.01965354
26wound healing, spreading of epidermal cells (GO:0035313)4.00383276
27positive regulation of chemokine biosynthetic process (GO:0045080)3.98197582
28positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.95454314
29glycolipid catabolic process (GO:0019377)3.95177513
30multicellular organismal macromolecule metabolic process (GO:0044259)3.88167678
31regulation of vitamin metabolic process (GO:0030656)3.86585371
32regulation of podosome assembly (GO:0071801)3.81595534
33metanephric mesenchyme development (GO:0072075)3.81398095
34basement membrane organization (GO:0071711)3.80692105
35cellular response to vitamin (GO:0071295)3.78826519
36kidney mesenchyme development (GO:0072074)3.77947612
37extracellular matrix disassembly (GO:0022617)3.77003535
38macrophage activation involved in immune response (GO:0002281)3.74071285
39multicellular organismal catabolic process (GO:0044243)3.71444998
40protein localization to cell surface (GO:0034394)3.70898200
41negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.69980151
42multicellular organismal metabolic process (GO:0044236)3.66652405
43hippo signaling (GO:0035329)3.63307146
44regulation of membrane protein ectodomain proteolysis (GO:0051043)3.59429954
45wound healing, spreading of cells (GO:0044319)3.55885398
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.54152364
47dermatan sulfate biosynthetic process (GO:0030208)3.53170746
48neutrophil activation involved in immune response (GO:0002283)3.53080527
49G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.52765125
50T-helper 1 type immune response (GO:0042088)3.51331694
51peptidyl-proline hydroxylation (GO:0019511)3.50413628
52protein localization to endosome (GO:0036010)3.49649278
53ceramide catabolic process (GO:0046514)3.47527180
54craniofacial suture morphogenesis (GO:0097094)3.45809017
55positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.43008294
56endocardial cushion development (GO:0003197)3.42440104
57positive regulation of monocyte chemotaxis (GO:0090026)3.41616822
58detection of molecule of bacterial origin (GO:0032490)3.39360372
59regulation of chemokine biosynthetic process (GO:0045073)3.39315553
60apoptotic cell clearance (GO:0043277)3.37700389
61glomerular basement membrane development (GO:0032836)3.37630791
62cellular response to vitamin D (GO:0071305)3.37331550
63positive regulation of heat generation (GO:0031652)3.34087125
64germ cell migration (GO:0008354)3.34067766
65amino sugar catabolic process (GO:0046348)3.33614578
66regulation of cytokine secretion involved in immune response (GO:0002739)3.33387127
67plasma membrane repair (GO:0001778)3.32555974
68response to thyroid hormone (GO:0097066)3.32268355
69cellular response to interferon-alpha (GO:0035457)3.31573199
70extracellular matrix assembly (GO:0085029)3.31013356
71negative regulation of nitric oxide biosynthetic process (GO:0045019)3.30670922
72cell migration involved in sprouting angiogenesis (GO:0002042)3.30190578
73monocyte chemotaxis (GO:0002548)3.28116253
74regulation of macrophage chemotaxis (GO:0010758)3.27597277
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.25853690
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.24088343
77negative regulation of cartilage development (GO:0061037)3.21260295
78hydrogen peroxide biosynthetic process (GO:0050665)3.18729251
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18060725
80barbed-end actin filament capping (GO:0051016)3.17291081
81positive regulation by symbiont of host defense response (GO:0052509)3.15799910
82modulation by symbiont of host defense response (GO:0052031)3.15799910
83modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.15799910
84modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.15799910
85positive regulation by organism of defense response of other organism involved in symbiotic interact3.15799910
86modulation by symbiont of host immune response (GO:0052553)3.15799910
87dermatan sulfate metabolic process (GO:0030205)3.14761858
88regulation of fever generation (GO:0031620)3.14557470
89regulation of tight junction assembly (GO:2000810)3.14402369
90positive regulation of epithelial to mesenchymal transition (GO:0010718)3.13192954
91embryonic cranial skeleton morphogenesis (GO:0048701)3.12949315
92* epoxygenase P450 pathway (GO:0019373)3.12097813
93substrate adhesion-dependent cell spreading (GO:0034446)3.10929013
94NIK/NF-kappaB signaling (GO:0038061)3.10724781
95chondrocyte development (GO:0002063)3.10516447
96eosinophil chemotaxis (GO:0048245)3.09942519
97positive regulation of leukocyte degranulation (GO:0043302)3.09000377
98vascular endothelial growth factor signaling pathway (GO:0038084)3.07441778
99regulation of monocyte chemotaxis (GO:0090025)3.06379298
100stress fiber assembly (GO:0043149)3.05840507
101mesodermal cell differentiation (GO:0048333)3.05796153
102protein hydroxylation (GO:0018126)3.05495345
103negative regulation of cytokine production involved in immune response (GO:0002719)3.05420423
104negative regulation of focal adhesion assembly (GO:0051895)3.04480405
105negative regulation of cell junction assembly (GO:1901889)3.04480405
106negative regulation of adherens junction organization (GO:1903392)3.04480405
107keratan sulfate catabolic process (GO:0042340)3.02943690
108adhesion of symbiont to host cell (GO:0044650)3.02422492
109virion attachment to host cell (GO:0019062)3.02422492
110negative regulation of catenin import into nucleus (GO:0035414)3.00087629
111* extracellular matrix organization (GO:0030198)2.99551182
112positive regulation of fibroblast migration (GO:0010763)2.98842388
113regulation of interferon-alpha production (GO:0032647)2.98754761
114* extracellular structure organization (GO:0043062)2.98251352
115planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95646745
116immunoglobulin mediated immune response (GO:0016064)2.93276365
117positive regulation of blood vessel endothelial cell migration (GO:0043536)2.92601515
118endothelial cell morphogenesis (GO:0001886)2.91928979
119decidualization (GO:0046697)2.91666867
120myeloid dendritic cell differentiation (GO:0043011)2.91186607
121sphingolipid catabolic process (GO:0030149)2.89081092
122negative regulation of embryonic development (GO:0045992)2.88376618
123regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.87372371
124extracellular negative regulation of signal transduction (GO:1900116)2.87290281
125extracellular regulation of signal transduction (GO:1900115)2.87290281
126positive regulation of osteoblast proliferation (GO:0033690)2.86955942
127cellular response to lipopolysaccharide (GO:0071222)2.86838717
128branching involved in labyrinthine layer morphogenesis (GO:0060670)2.86457617
129regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.86362688
130regulation of cholesterol storage (GO:0010885)2.86213376
131regulation of interferon-beta biosynthetic process (GO:0045357)2.85037170
132germinal center formation (GO:0002467)2.83765564
133outer ear morphogenesis (GO:0042473)2.83160690
134regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83096367
135cranial suture morphogenesis (GO:0060363)2.82878449
136* epithelial cell-cell adhesion (GO:0090136)2.82672817
137positive regulation of mesenchymal cell proliferation (GO:0002053)2.82423292
138regulation of mast cell degranulation (GO:0043304)2.81649289
139insulin-like growth factor receptor signaling pathway (GO:0048009)2.80470180
140regulation of T-helper 2 cell differentiation (GO:0045628)2.80461116
141regulation of nitric oxide biosynthetic process (GO:0045428)2.80126419
142middle ear morphogenesis (GO:0042474)2.79375511
143negative regulation of lipid storage (GO:0010888)2.79159602
144regulation of cartilage development (GO:0061035)2.78399729
145regulation of SMAD protein import into nucleus (GO:0060390)2.78115474
146granulocyte activation (GO:0036230)2.77715794
147cellular response to molecule of bacterial origin (GO:0071219)2.77231864
148eosinophil migration (GO:0072677)2.76984734
149response to laminar fluid shear stress (GO:0034616)2.76299882
150positive regulation of cellular amide metabolic process (GO:0034250)2.75957247
151N-acetylneuraminate metabolic process (GO:0006054)2.75877625
152cellular response to arsenic-containing substance (GO:0071243)2.74321155
153reactive oxygen species biosynthetic process (GO:1903409)2.74065990
154positive regulation of interleukin-6 production (GO:0032755)2.73774482
155cellular response to amino acid stimulus (GO:0071230)2.72828085
156interferon-gamma-mediated signaling pathway (GO:0060333)2.72458432
157substrate-dependent cell migration (GO:0006929)2.71514156
158* membrane lipid catabolic process (GO:0046466)2.71273840
159regulation of leukocyte degranulation (GO:0043300)2.70765657
160dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.70708069
161regulation of chondrocyte differentiation (GO:0032330)2.70673335
162positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.70239580
163regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.70000425
164eye morphogenesis (GO:0048592)2.69307706
165negative regulation of myeloid cell apoptotic process (GO:0033033)2.68455152
166positive regulation of macrophage activation (GO:0043032)2.68335863
167cell-substrate junction assembly (GO:0007044)2.68195436
168regulation of T-helper 1 cell differentiation (GO:0045625)2.67930330
169regulation of gastrulation (GO:0010470)2.67805407
170regulation of chronic inflammatory response (GO:0002676)2.67462499
171COPI coating of Golgi vesicle (GO:0048205)2.65517433
172Golgi transport vesicle coating (GO:0048200)2.65517433
173response to muramyl dipeptide (GO:0032495)2.64992457
174cell-matrix adhesion (GO:0007160)2.63764953
175negative chemotaxis (GO:0050919)2.63353453
176negative regulation of smooth muscle cell migration (GO:0014912)2.62329025
177smooth muscle tissue development (GO:0048745)2.62237345
178extracellular fibril organization (GO:0043206)2.62091593
179adherens junction assembly (GO:0034333)2.61928305
180positive regulation of nitric oxide biosynthetic process (GO:0045429)2.61761102
181cellular extravasation (GO:0045123)2.61596698
182blood vessel endothelial cell migration (GO:0043534)2.60799756
183positive regulation of interferon-alpha production (GO:0032727)2.60619228
184response to fluid shear stress (GO:0034405)2.60594706
185pinocytosis (GO:0006907)2.60421122
186adhesion of symbiont to host (GO:0044406)2.59183581
187vitamin D metabolic process (GO:0042359)2.58821258
188epithelial cell differentiation involved in prostate gland development (GO:0060742)2.57646903
189regulation of early endosome to late endosome transport (GO:2000641)2.57539320
190regulation of mast cell activation involved in immune response (GO:0033006)2.56971076
191iron ion import (GO:0097286)2.56442820
192macrophage activation (GO:0042116)2.55176165
193positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.54278454
194positive regulation of type 2 immune response (GO:0002830)2.54167644
195detection of external biotic stimulus (GO:0098581)2.53997598
196positive regulation of NF-kappaB import into nucleus (GO:0042346)2.53796436
197positive regulation of mast cell activation (GO:0033005)2.53043274
198type I interferon signaling pathway (GO:0060337)2.52996671
199cellular response to type I interferon (GO:0071357)2.52996671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.58131771
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.89612345
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.73841474
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.34075262
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.15984920
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.92835370
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.65451015
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.51144617
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.47083072
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.38269987
11CLOCK_20551151_ChIP-Seq_293T_Human3.37657318
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.35933440
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.27396799
14* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.22105299
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.07775510
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96867425
17* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.90908743
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.63837250
19CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.62461633
20* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.60303402
21CJUN_26792858_Chip-Seq_BT549_Human2.57658547
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.49767904
23* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.34392315
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.33413439
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.32058136
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31990674
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21547375
28* BRD4_25478319_ChIP-Seq_HGPS_Human2.20428646
29* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.17861987
30* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.17861987
31STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16134468
32VDR_24787735_ChIP-Seq_THP-1_Human2.14693195
33EP300_21415370_ChIP-Seq_HL-1_Mouse2.11423988
34* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.10149442
35BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05835113
36RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01675387
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98104648
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.92815803
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89475387
40VDR_24763502_ChIP-Seq_THP-1_Human1.88407065
41* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85703671
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83104287
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82995231
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82464810
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82464810
46SPI1_23127762_ChIP-Seq_K562_Human1.81323202
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79598831
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.73081262
49* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71592406
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.71026962
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.64096042
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63815222
53VDR_21846776_ChIP-Seq_THP-1_Human1.63811107
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62630520
55TP53_16413492_ChIP-PET_HCT116_Human1.62458663
56SPI1_23547873_ChIP-Seq_NB4_Human1.61635612
57TP53_18474530_ChIP-ChIP_U2OS_Human1.60833003
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59974753
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59893472
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56255555
61* ESR1_21235772_ChIP-Seq_MCF-7_Human1.54946414
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.54898641
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.54794956
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54717525
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54184702
66PU_27001747_Chip-Seq_BMDM_Mouse1.54012523
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53245815
68* ESR2_21235772_ChIP-Seq_MCF-7_Human1.51820200
69* TP53_20018659_ChIP-ChIP_R1E_Mouse1.51379905
70* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48801995
71* SOX2_20726797_ChIP-Seq_SW620_Human1.47517627
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.47511397
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47296587
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.46097475
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45969503
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45125321
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.43890220
78* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41893218
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39289052
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38984148
81TFEB_21752829_ChIP-Seq_HELA_Human1.38451056
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36657963
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36612796
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.36468245
85ATF3_27146783_Chip-Seq_COLON_Human1.34955572
86* LXR_22292898_ChIP-Seq_THP-1_Human1.33705303
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33694636
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33609881
89* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33157578
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33058370
91GATA1_22025678_ChIP-Seq_K562_Human1.30532364
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28144471
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27565195
94* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23779189
95TP53_22127205_ChIP-Seq_IMR90_Human1.20565362
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19720314
97TP53_23651856_ChIP-Seq_MEFs_Mouse1.18736471
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17086765
99* ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16676127
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16075446
101ZNF263_19887448_ChIP-Seq_K562_Human1.16015033
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15948067
103* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15889756
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14525578
105* EED_16625203_ChIP-ChIP_MESCs_Mouse1.13418453
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13048679
107TBX20_22328084_ChIP-Seq_HEART_Mouse1.12342653
108TBX20_22080862_ChIP-Seq_HEART_Mouse1.12342653
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.11308996
110* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10757919
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10259320
112TCF7_22412390_ChIP-Seq_EML_Mouse1.10150628
113SCL_19346495_ChIP-Seq_HPC-7_Human1.10104184
114* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09446326
115* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08424146
116* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08424146
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06573126
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06289837
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06009921
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05809805
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05501512
122* KLF5_25053715_ChIP-Seq_YYC3_Human1.04929821
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04730459
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04689873
125RACK7_27058665_Chip-Seq_MCF-7_Human1.04665526
126NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03494202
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03251697
128E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03211794
129MAF_26560356_Chip-Seq_TH1_Human1.02659888
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02290678
131* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02197859
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01978227
133ISL1_27105846_Chip-Seq_CPCs_Mouse1.01646139
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01321351
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00884347
136GATA1_19941826_ChIP-Seq_K562_Human1.00481671
137RXR_22108803_ChIP-Seq_LS180_Human0.99329475
138SA1_22415368_ChIP-Seq_MEFs_Mouse0.98410812
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.98389220
140P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97670511
141SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96044974
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95531340
143KDM2B_26808549_Chip-Seq_DND41_Human0.95173755
144KDM2B_26808549_Chip-Seq_K562_Human0.95030514
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.94973478
146* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94579120
147* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94353263
148CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94234091
149KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94007981
150* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93840590
151* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92993174
152LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92713679
153RUNX_20019798_ChIP-Seq_JUKART_Human0.92124677
154* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92088788
155* TP63_23658742_ChIP-Seq_EP156T_Human0.91535735
156SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91102493
157RXR_22158963_ChIP-Seq_LIVER_Mouse0.91083399
158NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90852655
159* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89787647
160GATA1_19941827_ChIP-Seq_MEL_Mouse0.88955506
161LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88620105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.03098459
2MP0005275_abnormal_skin_tensile5.25705112
3MP0003705_abnormal_hypodermis_morpholog4.75532026
4MP0005503_abnormal_tendon_morphology4.56164613
5MP0005058_abnormal_lysosome_morphology4.18465022
6MP0003303_peritoneal_inflammation3.98917267
7MP0003279_aneurysm3.87536203
8MP0001958_emphysema3.33366406
9MP0006082_CNS_inflammation3.19603344
10MP0009384_cardiac_valve_regurgitation3.12246324
11MP0005623_abnormal_meninges_morphology3.07003450
12MP0009840_abnormal_foam_cell3.05779987
13MP0002148_abnormal_hypersensitivity_rea2.94589912
14MP0003436_decreased_susceptibility_to2.84268430
15MP0004272_abnormal_basement_membrane2.69232494
16MP0010352_gastrointestinal_tract_polyps2.55832860
17MP0009785_altered_susceptibility_to2.54585213
18MP0000343_altered_response_to2.54171985
19MP0004510_myositis2.53521980
20MP0005257_abnormal_intraocular_pressure2.43179060
21MP0003191_abnormal_cellular_cholesterol2.40419404
22MP0002419_abnormal_innate_immunity2.38820239
23MP0003172_abnormal_lysosome_physiology2.35384890
24MP0003724_increased_susceptibility_to2.34752907
25MP0003566_abnormal_cell_adhesion2.28027144
26MP0006054_spinal_hemorrhage2.25838537
27MP0001835_abnormal_antigen_presentation2.24866842
28MP0003075_altered_response_to2.19182618
29MP0005387_immune_system_phenotype2.13682161
30MP0001790_abnormal_immune_system2.13682161
31MP0005451_abnormal_body_composition2.09546597
32MP0002060_abnormal_skin_morphology2.08575611
33MP0000604_amyloidosis2.07814181
34MP0005000_abnormal_immune_tolerance2.07512382
35MP0005508_abnormal_skeleton_morphology2.04742621
36MP0009764_decreased_sensitivity_to1.96976905
37MP0002295_abnormal_pulmonary_circulatio1.91512310
38MP0005025_abnormal_response_to1.89904919
39MP0005023_abnormal_wound_healing1.89072684
40MP0005671_abnormal_response_to1.85006785
41MP0001853_heart_inflammation1.84834637
42MP0003091_abnormal_cell_migration1.84396727
43MP0003385_abnormal_body_wall1.83057610
44MP0009278_abnormal_bone_marrow1.79385826
45MP0004947_skin_inflammation1.78162270
46MP0002139_abnormal_hepatobiliary_system1.77099545
47MP0002452_abnormal_antigen_presenting1.74740871
48MP0000685_abnormal_immune_system1.71773896
49MP0002254_reproductive_system_inflammat1.69537152
50MP0009250_abnormal_appendicular_skeleto1.68203118
51MP0010030_abnormal_orbit_morphology1.64192536
52MP0002723_abnormal_immune_serum1.52907000
53MP0009053_abnormal_anal_canal1.52350812
54MP0000858_altered_metastatic_potential1.51328226
55MP0001845_abnormal_inflammatory_respons1.50096045
56MP0002896_abnormal_bone_mineralization1.49574161
57MP0001299_abnormal_eye_distance/1.46943153
58MP0005167_abnormal_blood-brain_barrier1.45883343
59MP0001542_abnormal_bone_strength1.44170184
60MP0008469_abnormal_protein_level1.43926294
61MP0001243_abnormal_dermal_layer1.43864566
62MP0000013_abnormal_adipose_tissue1.41796914
63MP0000767_abnormal_smooth_muscle1.41581298
64MP0002405_respiratory_system_inflammati1.41019850
65MP0000733_abnormal_muscle_development1.36524337
66MP0002282_abnormal_trachea_morphology1.36409467
67MP0001545_abnormal_hematopoietic_system1.35913953
68MP0005397_hematopoietic_system_phenotyp1.35913953
69MP0002877_abnormal_melanocyte_morpholog1.34063629
70MP0003806_abnormal_nucleotide_metabolis1.34005510
71MP0001800_abnormal_humoral_immune1.33620093
72MP0002108_abnormal_muscle_morphology1.32655307
73MP0003690_abnormal_glial_cell1.31438237
74MP0005310_abnormal_salivary_gland1.29356034
75MP0001819_abnormal_immune_cell1.26634713
76MP0002420_abnormal_adaptive_immunity1.26145711
77MP0008004_abnormal_stomach_pH1.26008078
78MP0002168_other_aberrant_phenotype1.25386101
79MP0010155_abnormal_intestine_physiology1.25070313
80MP0001348_abnormal_lacrimal_gland1.24882410
81MP0000534_abnormal_ureter_morphology1.23717553
82MP0003942_abnormal_urinary_system1.23061523
83MP0003656_abnormal_erythrocyte_physiolo1.22565368
84MP0005166_decreased_susceptibility_to1.22361916
85MP0010368_abnormal_lymphatic_system1.21058570
86MP0005464_abnormal_platelet_physiology1.20915422
87MP0005390_skeleton_phenotype1.20541950
88MP0002933_joint_inflammation1.19108096
89MP0002932_abnormal_joint_morphology1.18573151
90MP0003828_pulmonary_edema1.17114838
91MP0000163_abnormal_cartilage_morphology1.14866872
92MP0003283_abnormal_digestive_organ1.14790490
93MP0005367_renal/urinary_system_phenotyp1.13016795
94MP0000516_abnormal_urinary_system1.13016795
95MP0000428_abnormal_craniofacial_morphol1.12013337
96MP0003300_gastrointestinal_ulcer1.11177900
97MP0002115_abnormal_skeleton_extremities1.10124548
98MP0003115_abnormal_respiratory_system1.10033495
99MP0002332_abnormal_exercise_endurance1.08008822
100MP0005165_increased_susceptibility_to1.05966786
101MP0004233_abnormal_muscle_weight1.05757896
102MP0005076_abnormal_cell_differentiation1.05198122
103MP0004134_abnormal_chest_morphology1.03674403
104MP0003045_fibrosis1.03634688
105MP0003755_abnormal_palate_morphology1.01725460
106MP0000920_abnormal_myelination1.01594121
107MP0004883_abnormal_blood_vessel0.99864529
108MP0003941_abnormal_skin_development0.99788081
109MP0000003_abnormal_adipose_tissue0.98117661
110MP0002113_abnormal_skeleton_development0.97347524
111MP0009333_abnormal_splenocyte_physiolog0.96823701
112MP0000371_diluted_coat_color0.94794585
113MP0003329_amyloid_beta_deposits0.94477293
114MP0001879_abnormal_lymphatic_vessel0.92673441
115MP0002249_abnormal_larynx_morphology0.91559029
116MP0008260_abnormal_autophagy0.91528312
117MP0002233_abnormal_nose_morphology0.88273345
118MP0003950_abnormal_plasma_membrane0.87666766
119MP0000432_abnormal_head_morphology0.86529886
120MP0002128_abnormal_blood_circulation0.85647006
121MP0000537_abnormal_urethra_morphology0.84562365
122MP0005647_abnormal_sex_gland0.83077642
123MP0000716_abnormal_immune_system0.82631785
124MP0001533_abnormal_skeleton_physiology0.81879103
125MP0000049_abnormal_middle_ear0.81607333
126MP0001614_abnormal_blood_vessel0.81555011
127MP0003937_abnormal_limbs/digits/tail_de0.81217062
128MP0003935_abnormal_craniofacial_develop0.80829860
129MP0002998_abnormal_bone_remodeling0.80736841
130MP0002133_abnormal_respiratory_system0.80140023
131MP0005388_respiratory_system_phenotype0.80140023
132MP0001915_intracranial_hemorrhage0.79706457
133MP0010234_abnormal_vibrissa_follicle0.79518149
134MP0000762_abnormal_tongue_morphology0.79140971
135MP0009763_increased_sensitivity_to0.78385753
136MP0002697_abnormal_eye_size0.78369979
137MP0005164_abnormal_response_to0.74183223
138MP0004185_abnormal_adipocyte_glucose0.74020217
139MP0002111_abnormal_tail_morphology0.74018887
140MP0002116_abnormal_craniofacial_bone0.73979808
141MP0000249_abnormal_blood_vessel0.73785718
142MP0001346_abnormal_lacrimal_gland0.73213173
143MP0001849_ear_inflammation0.72747046
144MP0005595_abnormal_vascular_smooth0.71877421
145MP0002109_abnormal_limb_morphology0.71866161
146MP0001177_atelectasis0.70819111
147MP0003795_abnormal_bone_structure0.70463162
148MP0002234_abnormal_pharynx_morphology0.69981743
149MP0003453_abnormal_keratinocyte_physiol0.69549807
150MP0003448_altered_tumor_morphology0.68780181
151MP0002925_abnormal_cardiovascular_devel0.67763568
152MP0003634_abnormal_glial_cell0.67377566
153* MP0005197_abnormal_uvea_morphology0.67174920
154MP0009765_abnormal_xenobiotic_induced0.66919050
155MP0008875_abnormal_xenobiotic_pharmacok0.66390698
156* MP0005193_abnormal_anterior_eye0.66147919
157MP0004808_abnormal_hematopoietic_stem0.65842329
158MP0001727_abnormal_embryo_implantation0.65632834
159MP0009780_abnormal_chondrocyte_physiolo0.65532902
160MP0002177_abnormal_outer_ear0.64869959
161MP0010307_abnormal_tumor_latency0.64558493
162MP0010771_integument_phenotype0.64379178
163MP0002092_abnormal_eye_morphology0.64005497
164MP0002089_abnormal_postnatal_growth/wei0.63990133
165MP0001175_abnormal_lung_morphology0.63622880
166MP0005375_adipose_tissue_phenotype0.63356047
167MP0001851_eye_inflammation0.61854324
168* MP0008874_decreased_physiological_sensi0.61730160
169MP0006138_congestive_heart_failure0.61720391
170MP0005248_abnormal_Harderian_gland0.60755739
171MP0001340_abnormal_eyelid_morphology0.60297957
172MP0000750_abnormal_muscle_regeneration0.60194473

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.67831151
2Premature rupture of membranes (HP:0001788)8.04577186
3Abnormality of liposaccharide metabolism (HP:0010968)7.64841484
4Abnormality of glycosphingolipid metabolism (HP:0004343)7.64841484
5Abnormality of glycolipid metabolism (HP:0010969)7.64841484
6Vacuolated lymphocytes (HP:0001922)5.82438247
7Aortic dissection (HP:0002647)5.14798953
8Peritonitis (HP:0002586)5.01537180
9Ankle contracture (HP:0006466)4.97447840
10Shallow orbits (HP:0000586)4.96911397
11Dysostosis multiplex (HP:0000943)4.95680482
12Soft skin (HP:0000977)4.89446507
13Increased cerebral lipofuscin (HP:0011813)4.88391645
14Atrophic scars (HP:0001075)4.82651331
15Aortic aneurysm (HP:0004942)4.55361539
16Abnormality of macrophages (HP:0004311)4.53031451
17Bladder diverticulum (HP:0000015)4.48722326
18Loss of speech (HP:0002371)4.23022734
19Dilatation of the ascending aorta (HP:0005111)4.16854720
20Abnormality of dentin (HP:0010299)4.10099537
21Cerebral aneurysm (HP:0004944)4.08012843
22Systemic lupus erythematosus (HP:0002725)4.07983163
23Broad metatarsal (HP:0001783)4.03362288
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.94801698
25Abnormality of polysaccharide metabolism (HP:0011012)3.94801698
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.94801698
27Disinhibition (HP:0000734)3.94575872
28Cervical subluxation (HP:0003308)3.91853572
29Follicular hyperkeratosis (HP:0007502)3.90241634
30Urinary glycosaminoglycan excretion (HP:0003541)3.87336607
31Mucopolysacchariduria (HP:0008155)3.87336607
32Fragile skin (HP:0001030)3.85392883
33Increased neuronal autofluorescent lipopigment (HP:0002074)3.84035109
34Genu recurvatum (HP:0002816)3.83039900
35Neonatal short-limb short stature (HP:0008921)3.77932316
36Wrist flexion contracture (HP:0001239)3.64015905
37Recurrent bacterial skin infections (HP:0005406)3.63536900
38Nuclear cataract (HP:0100018)3.62960195
39Recurrent abscess formation (HP:0002722)3.61437455
40Vascular tortuosity (HP:0004948)3.57950605
41Wormian bones (HP:0002645)3.53687668
42Mitral valve prolapse (HP:0001634)3.52784938
43Eczematoid dermatitis (HP:0000976)3.48901536
44Mutism (HP:0002300)3.46587324
45Neurofibrillary tangles (HP:0002185)3.40855992
46Biconcave vertebral bodies (HP:0004586)3.36890149
47Myocardial infarction (HP:0001658)3.34333455
48Vertebral compression fractures (HP:0002953)3.33190663
49Blue sclerae (HP:0000592)3.33115303
50Bowel diverticulosis (HP:0005222)3.29980205
51Spinal rigidity (HP:0003306)3.06770499
52Axonal loss (HP:0003447)3.06173739
53Arterial tortuosity (HP:0005116)3.03777385
54Recurrent gram-negative bacterial infections (HP:0005420)3.00419955
55Type 1 muscle fiber predominance (HP:0003803)2.99952988
56Hyperextensible skin (HP:0000974)2.91267350
57Infantile muscular hypotonia (HP:0008947)2.88663582
58Autoimmune thrombocytopenia (HP:0001973)2.84803681
59Overgrowth (HP:0001548)2.82381599
60Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.77999197
61Abnormality of the vasculature of the conjunctiva (HP:0008054)2.73983667
62Elbow flexion contracture (HP:0002987)2.73690949
63Orchitis (HP:0100796)2.73329937
64Mediastinal lymphadenopathy (HP:0100721)2.70977745
65Abnormal delivery (HP:0001787)2.67659665
66Apathy (HP:0000741)2.65635263
67Aneurysm (HP:0002617)2.63483019
68Diminished motivation (HP:0000745)2.62635427
69Cerebral inclusion bodies (HP:0100314)2.60401888
70Glomerulonephritis (HP:0000099)2.56444507
71Deviation of the hallux (HP:0010051)2.52941847
72Retrobulbar optic neuritis (HP:0100654)2.51955856
73Optic neuritis (HP:0100653)2.51955856
74Abnormality of the acetabulum (HP:0003170)2.49739184
75Ectopia lentis (HP:0001083)2.49677770
76Hallux valgus (HP:0001822)2.48504334
77Increased connective tissue (HP:0009025)2.44692413
78Metaphyseal irregularity (HP:0003025)2.44384839
79Thin bony cortex (HP:0002753)2.43008307
80Slender build (HP:0001533)2.40044470
81Hematochezia (HP:0002573)2.39784217
82Neuronal loss in central nervous system (HP:0002529)2.39404876
83Asymmetric septal hypertrophy (HP:0001670)2.38032452
84Wide anterior fontanel (HP:0000260)2.37968103
85Abnormality of the peritoneum (HP:0002585)2.36432494
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.36099804
87Osteolytic defects of the hand bones (HP:0009699)2.36099804
88Myositis (HP:0100614)2.35939873
89Camptodactyly of toe (HP:0001836)2.35433985
90Increased serum ferritin (HP:0003281)2.34909079
91Increased variability in muscle fiber diameter (HP:0003557)2.34395099
92Tibial bowing (HP:0002982)2.33026453
93Progressive neurologic deterioration (HP:0002344)2.32123029
94Mitral regurgitation (HP:0001653)2.31528024
95Breech presentation (HP:0001623)2.28790874
96Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.27968747
97Joint laxity (HP:0001388)2.26800343
98Prolonged neonatal jaundice (HP:0006579)2.25534382
99Absent frontal sinuses (HP:0002688)2.25290356
100Hepatosplenomegaly (HP:0001433)2.21307238
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21026121
102Bone pain (HP:0002653)2.19573786
103Broad ribs (HP:0000885)2.17613503
104Knee flexion contracture (HP:0006380)2.15456599
105Spinal cord lesions (HP:0100561)2.14927270
106Syringomyelia (HP:0003396)2.14927270
107Asymmetry of the thorax (HP:0001555)2.13682719
108Ulnar bowing (HP:0003031)2.13148373
109Increased density of long bones (HP:0006392)2.13058049
110Mesomelia (HP:0003027)2.12756099
111Cardiomegaly (HP:0001640)2.11698868
112Mildly elevated creatine phosphokinase (HP:0008180)2.11219607
113Protuberant abdomen (HP:0001538)2.10663543
114Femoral bowing (HP:0002980)2.10455857
115Upper motor neuron abnormality (HP:0002127)2.08297488
116Coronal craniosynostosis (HP:0004440)2.05311550
117Purpura (HP:0000979)2.04798499
118Inappropriate behavior (HP:0000719)2.03680316
119Abnormality of skeletal muscle fiber size (HP:0012084)2.03376596
120Amyloidosis (HP:0011034)2.03279057
121Coxa vara (HP:0002812)2.02605941
122Short nail (HP:0001799)2.02177727
123Bell-shaped thorax (HP:0001591)2.02171046
124Venous abnormality (HP:0002624)2.01719401
125Ovoid vertebral bodies (HP:0003300)2.00281788
126Nonimmune hydrops fetalis (HP:0001790)1.98686128
127Pathologic fracture (HP:0002756)1.98203000
128Aortic regurgitation (HP:0001659)1.97927685
129Interstitial pulmonary disease (HP:0006530)1.97868985
130Spondylolisthesis (HP:0003302)1.97051169
131Pulmonary infiltrates (HP:0002113)1.96313576
132J-shaped sella turcica (HP:0002680)1.95189380
133Agnosia (HP:0010524)1.94848846
134Abnormality of the anterior chamber (HP:0000593)1.94011614
135Gingivitis (HP:0000230)1.93547091
136Osteoarthritis (HP:0002758)1.92993219
137Round ear (HP:0100830)1.92962633
138Esophageal varix (HP:0002040)1.92071151
139Hypoplasia of the iris (HP:0007676)1.91593067
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.91520032
141Stomatitis (HP:0010280)1.91375264
142Venous insufficiency (HP:0005293)1.91128499
143Recurrent skin infections (HP:0001581)1.90015363
144Broad long bones (HP:0005622)1.89908464
145Basal ganglia calcification (HP:0002135)1.89002122
146Complement deficiency (HP:0004431)1.87019492
147Dementia (HP:0000726)1.87009663
148Osteopenia (HP:0000938)1.86385510
149Abnormality of the periventricular white matter (HP:0002518)1.84866630
150Tetraparesis (HP:0002273)1.84668547
151Bowing of the arm (HP:0006488)1.83483282
152Bowed forearm bones (HP:0003956)1.83483282
153Decreased skull ossification (HP:0004331)1.82530935
154Microglossia (HP:0000171)1.82192558
155Inguinal hernia (HP:0000023)1.81101957
156Thoracic kyphosis (HP:0002942)1.81023654
157Upper limb amyotrophy (HP:0009129)1.80370775
158Distal upper limb amyotrophy (HP:0007149)1.80370775
159Joint stiffness (HP:0001387)1.80140242
160Spinal cord compression (HP:0002176)1.80013014
161Radial bowing (HP:0002986)1.79567290
162Abnormality of the calcaneus (HP:0008364)1.78986026
163Increased CSF protein (HP:0002922)1.78785157
164Short 4th metacarpal (HP:0010044)1.77803240
165Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77803240
166Morphological abnormality of the middle ear (HP:0008609)1.75328223
167Flexion contracture of toe (HP:0005830)1.73914736
168Joint contractures involving the joints of the feet (HP:0100492)1.73914736
169Polyneuropathy (HP:0001271)1.73252243
170Tarsal synostosis (HP:0008368)1.72018674
171Scapular winging (HP:0003691)1.71565875
172Personality changes (HP:0000751)1.71131855
173Abnormality of complement system (HP:0005339)1.70010193
174Abnormality of skull ossification (HP:0002703)1.69976055
175Platyspondyly (HP:0000926)1.69934380
176Disproportionate tall stature (HP:0001519)1.69083830
177Protruding ear (HP:0000411)1.68940031
178Spontaneous hematomas (HP:0007420)1.68809867
179Peripheral demyelination (HP:0011096)1.68487098
180Abnormality of iron homeostasis (HP:0011031)1.67112039
181Chronic obstructive pulmonary disease (HP:0006510)1.66634333
182Obstructive lung disease (HP:0006536)1.66634333
183Flared iliac wings (HP:0002869)1.66184896
184Progressive visual loss (HP:0000529)1.64964156
185Hemoptysis (HP:0002105)1.64721564
186Acrocyanosis (HP:0001063)1.64170749
187Retinal atrophy (HP:0001105)1.62316417
188Petechiae (HP:0000967)1.61792793
189Abnormality of the frontal sinuses (HP:0002687)1.59988070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.43165455
2DDR24.90727267
3TTN4.20093071
4TRIB33.70154561
5NME23.60800476
6PDGFRA3.57971475
7LATS13.25500967
8LATS22.95580327
9GRK72.88867330
10MAP3K142.87428007
11EPHB22.82319807
12PKN22.51146906
13SIK12.46242390
14ERN12.45395471
15TYK22.26982215
16PAK22.25349207
17TBK12.22311689
18BLK2.22157042
19MATK2.21811643
20TAOK22.21808104
21PRPF4B2.10580149
22PAK32.08986387
23FER2.00069504
24RIPK11.95823295
25PTK21.83785657
26RIPK41.76733967
27CSK1.76494089
28TRPM71.75988627
29FRK1.74989529
30EPHA31.74272586
31LRRK21.73340084
32FGR1.73161286
33IRAK41.66585272
34IKBKB1.60018349
35DMPK1.55490020
36PTK61.53913917
37BMX1.53211043
38MAP2K31.50077107
39TESK11.49781787
40STK31.46960526
41ACVR1B1.36179673
42PAK41.34122641
43NEK91.27244085
44IKBKE1.25626726
45PDGFRB1.25434134
46MAP3K111.23823245
47PIK3CA1.22814157
48FGFR11.19831697
49SCYL21.19367754
50BMPR21.19356915
51EPHA21.17106952
52ROCK11.15366424
53LIMK11.14700132
54PTK2B1.14570729
55RPS6KA41.14492311
56CSF1R1.14063920
57IRAK21.13535913
58TGFBR21.13147052
59CAMK1G1.11891258
60CHUK1.11542570
61MAP3K131.10139699
62EEF2K1.07827681
63MET1.07673875
64CAMK1D1.05641359
65ZAP701.05051474
66EPHB11.04237653
67FGFR21.03129011
68PIM21.02635371
69MTOR1.02290546
70NTRK11.01057109
71MOS0.99535221
72CDK60.96676499
73MAP2K10.93338234
74PLK20.86114243
75ERBB30.85400860
76MAP3K10.84740606
77ROCK20.83687153
78MYLK0.80985294
79ADRBK20.79297219
80PIK3CG0.78544572
81SIK30.75143642
82FGFR30.74941024
83RET0.74206448
84ILK0.73766507
85INSR0.71999958
86DYRK1B0.71231393
87STK100.71207907
88JAK10.68951400
89FLT30.68909051
90JAK20.68361692
91ICK0.67616150
92DAPK30.67608321
93IRAK10.66456894
94MAP3K50.60951507
95PRKD10.59213089
96FGFR40.58415785
97ABL20.57013060
98MARK30.56117110
99RPS6KC10.55447898
100RPS6KL10.55447898
101TYRO30.54024740
102KIT0.53417831
103PDPK10.52829643
104LYN0.52271405
105MAP4K10.51402252
106CLK10.51124297
107SRC0.50119876
108LMTK20.50114361
109PAK10.48300706
110ADRBK10.48178279
111CDC42BPA0.48063208
112STK38L0.47213664
113ARAF0.46979322
114HCK0.46583606
115MELK0.46385057
116TESK20.45868711
117NUAK10.45508441
118TGFBR10.45219392
119PRKCH0.45187872
120PRKD20.44474150
121MAP3K20.43741165
122MAP3K80.42749658
123PAK60.41444735
124KSR20.41442761
125MAPK40.40797123
126PDK20.40272607
127MAP3K100.40082944
128MAP3K30.39366840
129MAPK70.39359028
130TAOK10.38467292
131ERBB40.38425378
132PDK30.37978394
133PDK40.37978394
134RPS6KA60.37830232
135MAP3K120.36785897
136WNK10.35998197
137MAPKAPK30.35700568
138NEK60.34987169
139LCK0.34912898
140ABL10.34382786
141CAMKK10.34184929
142MAPKAPK20.34004303
143SMG10.32726047
144IGF1R0.32495102
145PRKG20.32440141
146ALK0.32061717
147CDK140.32050678
148MAP3K60.30092232
149MST1R0.29969781
150MAP2K60.29869591
151PDK10.29610405
152ERBB20.29069836
153RPS6KA20.28961013
154CAMKK20.26353347
155JAK30.26255819
156PRKCE0.25327506
157MAPK10.25276985

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.30271201
2Other glycan degradation_Homo sapiens_hsa005113.81568953
3Focal adhesion_Homo sapiens_hsa045103.17453277
4Rheumatoid arthritis_Homo sapiens_hsa053232.66616103
5Osteoclast differentiation_Homo sapiens_hsa043802.61387119
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.57887085
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.56403488
8Proteoglycans in cancer_Homo sapiens_hsa052052.54854694
9Adherens junction_Homo sapiens_hsa045202.47850408
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.42862827
11Protein digestion and absorption_Homo sapiens_hsa049742.39660105
12Bladder cancer_Homo sapiens_hsa052192.39246504
13Staphylococcus aureus infection_Homo sapiens_hsa051502.37171320
14Amoebiasis_Homo sapiens_hsa051462.33615583
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.24608755
16TGF-beta signaling pathway_Homo sapiens_hsa043502.22451493
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.12969611
18Tuberculosis_Homo sapiens_hsa051522.09182970
19Small cell lung cancer_Homo sapiens_hsa052222.04829291
20Hippo signaling pathway_Homo sapiens_hsa043902.03970027
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.96835651
22Malaria_Homo sapiens_hsa051441.95930354
23Pertussis_Homo sapiens_hsa051331.95564507
24Legionellosis_Homo sapiens_hsa051341.92697723
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82600176
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78031930
27Allograft rejection_Homo sapiens_hsa053301.75566876
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74839106
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74754479
30Asthma_Homo sapiens_hsa053101.74714445
31Caffeine metabolism_Homo sapiens_hsa002321.72031630
32* MicroRNAs in cancer_Homo sapiens_hsa052061.71744448
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67211741
34Chronic myeloid leukemia_Homo sapiens_hsa052201.64935589
35Graft-versus-host disease_Homo sapiens_hsa053321.60268796
36Basal cell carcinoma_Homo sapiens_hsa052171.60217197
37Melanoma_Homo sapiens_hsa052181.58534028
38Dilated cardiomyopathy_Homo sapiens_hsa054141.57607653
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.57121153
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.56998611
41p53 signaling pathway_Homo sapiens_hsa041151.51898759
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46902539
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.46003254
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44894698
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.41051851
46Influenza A_Homo sapiens_hsa051641.39602101
47Hedgehog signaling pathway_Homo sapiens_hsa043401.38366855
48Pancreatic cancer_Homo sapiens_hsa052121.34011051
49Glioma_Homo sapiens_hsa052141.32870534
50Antigen processing and presentation_Homo sapiens_hsa046121.30466602
51Autoimmune thyroid disease_Homo sapiens_hsa053201.30396384
52Tight junction_Homo sapiens_hsa045301.27455201
53Shigellosis_Homo sapiens_hsa051311.27449826
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26446154
55Prion diseases_Homo sapiens_hsa050201.21724696
56Hematopoietic cell lineage_Homo sapiens_hsa046401.18317986
57Prostate cancer_Homo sapiens_hsa052151.17256051
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15792081
59Hepatitis C_Homo sapiens_hsa051601.14780434
60Pathways in cancer_Homo sapiens_hsa052001.14676335
61Viral myocarditis_Homo sapiens_hsa054161.13204668
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13166295
63Platelet activation_Homo sapiens_hsa046111.11149502
64B cell receptor signaling pathway_Homo sapiens_hsa046621.11060400
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10263259
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10017131
67Type I diabetes mellitus_Homo sapiens_hsa049401.08630025
68African trypanosomiasis_Homo sapiens_hsa051431.08359129
69Sphingolipid metabolism_Homo sapiens_hsa006001.05182400
70Rap1 signaling pathway_Homo sapiens_hsa040151.03741620
71Chemokine signaling pathway_Homo sapiens_hsa040621.03162152
72Collecting duct acid secretion_Homo sapiens_hsa049661.00607339
73Measles_Homo sapiens_hsa051620.99889381
74Axon guidance_Homo sapiens_hsa043600.99451735
75Vibrio cholerae infection_Homo sapiens_hsa051100.96321126
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94186610
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.93684881
78Wnt signaling pathway_Homo sapiens_hsa043100.92613364
79Toxoplasmosis_Homo sapiens_hsa051450.90760923
80Herpes simplex infection_Homo sapiens_hsa051680.90675156
81TNF signaling pathway_Homo sapiens_hsa046680.90153326
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89980260
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89730080
84Renal cell carcinoma_Homo sapiens_hsa052110.89104996
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.88374113
86HTLV-I infection_Homo sapiens_hsa051660.85677861
87Mineral absorption_Homo sapiens_hsa049780.84926712
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84260959
89Endometrial cancer_Homo sapiens_hsa052130.83563812
90Colorectal cancer_Homo sapiens_hsa052100.80072906
91mTOR signaling pathway_Homo sapiens_hsa041500.79869645
92Phagosome_Homo sapiens_hsa041450.79809936
93Melanogenesis_Homo sapiens_hsa049160.76912257
94Salmonella infection_Homo sapiens_hsa051320.72393402
95Thyroid cancer_Homo sapiens_hsa052160.71646012
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69855179
97Viral carcinogenesis_Homo sapiens_hsa052030.69176269
98Galactose metabolism_Homo sapiens_hsa000520.67594836
99HIF-1 signaling pathway_Homo sapiens_hsa040660.67215918
100Renin-angiotensin system_Homo sapiens_hsa046140.66513958
101Hepatitis B_Homo sapiens_hsa051610.66395922
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65509964
103Endocytosis_Homo sapiens_hsa041440.62645968
104Gap junction_Homo sapiens_hsa045400.60905461
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59923423
106Estrogen signaling pathway_Homo sapiens_hsa049150.59108859
107FoxO signaling pathway_Homo sapiens_hsa040680.58763131
108* Ovarian steroidogenesis_Homo sapiens_hsa049130.57903628
109Nitrogen metabolism_Homo sapiens_hsa009100.57773849
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57138263
111Apoptosis_Homo sapiens_hsa042100.56493223
112T cell receptor signaling pathway_Homo sapiens_hsa046600.55952201
113Lysosome_Homo sapiens_hsa041420.54471463
114Non-small cell lung cancer_Homo sapiens_hsa052230.53696781
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.53617695
116AMPK signaling pathway_Homo sapiens_hsa041520.53249265
117VEGF signaling pathway_Homo sapiens_hsa043700.52554727
118Epstein-Barr virus infection_Homo sapiens_hsa051690.52194146
119PPAR signaling pathway_Homo sapiens_hsa033200.49796586
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49736495
121Insulin resistance_Homo sapiens_hsa049310.49446567
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.49188605
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48874384
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.48311164
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47351379
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.47149706
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.47065925
128Ras signaling pathway_Homo sapiens_hsa040140.46292213
129Thyroid hormone synthesis_Homo sapiens_hsa049180.43502951
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43413070
131GnRH signaling pathway_Homo sapiens_hsa049120.42252446
132Sulfur metabolism_Homo sapiens_hsa009200.41866716
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41012518
134ErbB signaling pathway_Homo sapiens_hsa040120.39682304
135N-Glycan biosynthesis_Homo sapiens_hsa005100.38980562
136Leishmaniasis_Homo sapiens_hsa051400.37787580
137Pentose phosphate pathway_Homo sapiens_hsa000300.36836409
138Prolactin signaling pathway_Homo sapiens_hsa049170.36495663
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.35541951
140Type II diabetes mellitus_Homo sapiens_hsa049300.35437761
141Glutathione metabolism_Homo sapiens_hsa004800.35215845
142Fructose and mannose metabolism_Homo sapiens_hsa000510.34789597
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34366032
144Acute myeloid leukemia_Homo sapiens_hsa052210.33893208
145Insulin signaling pathway_Homo sapiens_hsa049100.33556777
146Complement and coagulation cascades_Homo sapiens_hsa046100.32196670
147Lysine degradation_Homo sapiens_hsa003100.32150642
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32140927
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31578496
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31489247
151Notch signaling pathway_Homo sapiens_hsa043300.31156799
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30258130
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.29770828

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »