CYP20A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-fucose catabolic process (GO:0042355)4.91895285
2fucose catabolic process (GO:0019317)4.91895285
3L-fucose metabolic process (GO:0042354)4.91895285
4DNA deamination (GO:0045006)4.71498689
5axon ensheathment in central nervous system (GO:0032291)4.67919915
6central nervous system myelination (GO:0022010)4.67919915
7protein prenylation (GO:0018342)4.40905609
8prenylation (GO:0097354)4.40905609
9nucleotide transmembrane transport (GO:1901679)4.12916104
10fatty acid elongation (GO:0030497)4.10011304
11signal peptide processing (GO:0006465)4.07535102
12cholesterol biosynthetic process (GO:0006695)3.97851302
13platelet dense granule organization (GO:0060155)3.97245161
14isoprenoid biosynthetic process (GO:0008299)3.92357529
15regulation of metalloenzyme activity (GO:0048552)3.70849199
16sterol biosynthetic process (GO:0016126)3.61505488
17behavioral response to nicotine (GO:0035095)3.50955501
18piRNA metabolic process (GO:0034587)3.48961576
19water-soluble vitamin biosynthetic process (GO:0042364)3.46495286
20purine ribonucleotide transport (GO:0015868)3.40750015
21mesenchymal cell differentiation involved in renal system development (GO:2001012)3.34404520
22mesenchymal cell differentiation involved in kidney development (GO:0072161)3.34404520
23positive regulation of osteoblast proliferation (GO:0033690)3.33165290
24respiratory chain complex IV assembly (GO:0008535)3.31106636
25dermatan sulfate biosynthetic process (GO:0030208)3.26759054
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25142288
27tryptophan catabolic process (GO:0006569)3.24539459
28indole-containing compound catabolic process (GO:0042436)3.24539459
29indolalkylamine catabolic process (GO:0046218)3.24539459
30preassembly of GPI anchor in ER membrane (GO:0016254)3.22732160
31response to pheromone (GO:0019236)3.22606245
32indolalkylamine metabolic process (GO:0006586)3.16800179
33dermatan sulfate metabolic process (GO:0030205)3.13175862
34protein polyglutamylation (GO:0018095)3.11012627
35positive regulation of actin filament depolymerization (GO:0030836)3.10729853
36protein-cofactor linkage (GO:0018065)3.10542850
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10532609
38detection of light stimulus involved in sensory perception (GO:0050962)3.10199872
39detection of light stimulus involved in visual perception (GO:0050908)3.10199872
40protein complex biogenesis (GO:0070271)3.09824710
41DNA demethylation (GO:0080111)3.08976557
42negative regulation of myoblast differentiation (GO:0045662)3.04449282
43nonmotile primary cilium assembly (GO:0035058)3.00699493
44GPI anchor biosynthetic process (GO:0006506)2.99946419
45regulation of cilium movement (GO:0003352)2.99735681
46tryptophan metabolic process (GO:0006568)2.99571779
47neutrophil activation involved in immune response (GO:0002283)2.97911770
48regulation of meiosis I (GO:0060631)2.97662334
49DNA ligation (GO:0006266)2.97197929
50cytochrome complex assembly (GO:0017004)2.95791287
51recombinational repair (GO:0000725)2.94984494
52axoneme assembly (GO:0035082)2.94851599
53double-strand break repair via homologous recombination (GO:0000724)2.94845653
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93784853
55mitochondrial respiratory chain complex I assembly (GO:0032981)2.93784853
56NADH dehydrogenase complex assembly (GO:0010257)2.93784853
57kynurenine metabolic process (GO:0070189)2.93758296
58response to redox state (GO:0051775)2.93463871
59RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92623372
60mitochondrial respiratory chain complex assembly (GO:0033108)2.91203089
61long-chain fatty acid biosynthetic process (GO:0042759)2.91190862
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.89921721
63synapsis (GO:0007129)2.88499234
64cilium morphogenesis (GO:0060271)2.88299678
65cellular ketone body metabolic process (GO:0046950)2.86590810
66establishment of protein localization to mitochondrial membrane (GO:0090151)2.84593021
67DNA double-strand break processing (GO:0000729)2.84552723
68protein heterotetramerization (GO:0051290)2.84441757
69regulation of mitotic spindle checkpoint (GO:1903504)2.81212357
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81212357
71cell proliferation involved in kidney development (GO:0072111)2.78665676
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78233373
73reciprocal meiotic recombination (GO:0007131)2.77970793
74reciprocal DNA recombination (GO:0035825)2.77970793
75metanephric mesenchyme development (GO:0072075)2.77474358
76retinal cone cell development (GO:0046549)2.74476510
77replication fork processing (GO:0031297)2.74428854
78amino acid salvage (GO:0043102)2.73960501
79L-methionine salvage (GO:0071267)2.73960501
80L-methionine biosynthetic process (GO:0071265)2.73960501
81nucleotide transport (GO:0006862)2.73575726
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72079454
83C-terminal protein lipidation (GO:0006501)2.71767073
84mannosylation (GO:0097502)2.71290641
85negative regulation of telomere maintenance (GO:0032205)2.70726011
86mitotic nuclear envelope reassembly (GO:0007084)2.70694631
87nuclear envelope reassembly (GO:0031468)2.70694631
88oxidative demethylation (GO:0070989)2.70357103
89L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69765423
90positive regulation of chemokine secretion (GO:0090197)2.67493288
91regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.67398764
92regulation of osteoblast proliferation (GO:0033688)2.67125369
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66839301
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66839301
95positive regulation of oligodendrocyte differentiation (GO:0048714)2.66320754
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.65951184
97termination of RNA polymerase III transcription (GO:0006386)2.65951184
98C-terminal protein amino acid modification (GO:0018410)2.65776029
99import into cell (GO:0098657)2.65458443
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.64904231
101extracellular matrix assembly (GO:0085029)2.64376271
102neural tube formation (GO:0001841)2.63320566
103ketone body metabolic process (GO:1902224)2.63171772
104meiotic chromosome segregation (GO:0045132)2.62793327
105cell differentiation involved in metanephros development (GO:0072202)2.62167928
106CENP-A containing nucleosome assembly (GO:0034080)2.61827092
107limb bud formation (GO:0060174)2.61608261
108centriole replication (GO:0007099)2.61203192
109protein neddylation (GO:0045116)2.58980333
110seminiferous tubule development (GO:0072520)2.58924173
111GPI anchor metabolic process (GO:0006505)2.58560887
112regulation of T cell migration (GO:2000404)2.56812091
113methionine biosynthetic process (GO:0009086)2.56571823
114positive regulation of defense response to virus by host (GO:0002230)2.55316596
115estrogen biosynthetic process (GO:0006703)2.55127225
116male meiosis I (GO:0007141)2.54751550
117photoreceptor cell maintenance (GO:0045494)2.53959085
118myelination (GO:0042552)2.53796962
119regulation of glucokinase activity (GO:0033131)2.53773878
120regulation of hexokinase activity (GO:1903299)2.53773878
121retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52899041
122phagocytosis, recognition (GO:0006910)2.52756484
123peptidyl-histidine modification (GO:0018202)2.52364680
124epithelial cilium movement (GO:0003351)2.51299273
125DNA dealkylation (GO:0035510)2.50328033
126DNA methylation involved in gamete generation (GO:0043046)2.50106983
127ensheathment of neurons (GO:0007272)2.49647850
128axon ensheathment (GO:0008366)2.49647850
129cytidine catabolic process (GO:0006216)2.49555419
130cytidine deamination (GO:0009972)2.49555419
131cytidine metabolic process (GO:0046087)2.49555419
132somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.47752835
133isotype switching (GO:0045190)2.47752835
134somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.47752835
135astrocyte differentiation (GO:0048708)2.47036277
136protein K6-linked ubiquitination (GO:0085020)2.45999322
137protein K11-linked deubiquitination (GO:0035871)2.45549902
138negative regulation of T cell receptor signaling pathway (GO:0050860)2.44566833
139regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.43478807
140ubiquinone biosynthetic process (GO:0006744)2.43450676
141kidney mesenchyme development (GO:0072074)2.42250400
142protein localization to cilium (GO:0061512)2.41892274
143bone trabecula formation (GO:0060346)2.40727582
144collagen fibril organization (GO:0030199)2.40632641
145photoreceptor cell development (GO:0042461)2.38652142
146amyloid precursor protein metabolic process (GO:0042982)2.38588387
147regulation of mitochondrial translation (GO:0070129)2.38395644
148terpenoid biosynthetic process (GO:0016114)2.36995094
149ER overload response (GO:0006983)2.36138306
150response to X-ray (GO:0010165)2.35957929
151myoblast migration (GO:0051451)2.35572012
152dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.35204153
153proteasome assembly (GO:0043248)2.35095547
154cell proliferation involved in metanephros development (GO:0072203)2.34992056
155oligodendrocyte differentiation (GO:0048709)2.32314573
156transcription initiation from RNA polymerase I promoter (GO:0006361)2.32203406
157adenine nucleotide transport (GO:0051503)2.32173338
158chromatin remodeling at centromere (GO:0031055)2.32169370
159purine nucleotide transport (GO:0015865)2.31588798
160establishment of integrated proviral latency (GO:0075713)2.31305444
161extracellular fibril organization (GO:0043206)2.30924372
162mitotic G2 DNA damage checkpoint (GO:0007095)2.30604163
163mesenchymal cell proliferation (GO:0010463)2.29291609
164negative regulation of mast cell activation (GO:0033004)2.28661907
165telomere maintenance via recombination (GO:0000722)2.28189337
166wound healing, spreading of epidermal cells (GO:0035313)2.28091633
167negative regulation of JUN kinase activity (GO:0043508)2.27851446
168termination of RNA polymerase I transcription (GO:0006363)2.27596911
169wound healing, spreading of cells (GO:0044319)2.26164288
170superoxide anion generation (GO:0042554)2.26152210
171astrocyte development (GO:0014002)2.24826584
172cranial suture morphogenesis (GO:0060363)2.24731450
173regulation of integrin-mediated signaling pathway (GO:2001044)2.23407571
174phagocytosis, engulfment (GO:0006911)2.23224434
175sequestering of extracellular ligand from receptor (GO:0035581)2.23211844
176cellular response to gamma radiation (GO:0071480)2.22583306
177transcription from RNA polymerase I promoter (GO:0006360)2.20889435
178mismatch repair (GO:0006298)2.19383117
179fibril organization (GO:0097435)2.19033384
180response to follicle-stimulating hormone (GO:0032354)2.17839049
181chondrocyte proliferation (GO:0035988)2.17744049
182telomere maintenance via semi-conservative replication (GO:0032201)2.16764853
183eye photoreceptor cell differentiation (GO:0001754)2.14325343
184photoreceptor cell differentiation (GO:0046530)2.14325343
185negative regulation of stem cell proliferation (GO:2000647)2.13216414
186establishment of viral latency (GO:0019043)2.12462152
187response to lipoprotein particle (GO:0055094)2.11824710
188mesenchymal cell differentiation (GO:0048762)2.11788459
189extracellular regulation of signal transduction (GO:1900115)2.11648720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.03398967
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.92242908
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.86192191
4VDR_22108803_ChIP-Seq_LS180_Human3.57600030
5ZNF274_21170338_ChIP-Seq_K562_Hela3.48834954
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10574374
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94489138
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.77327228
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59502575
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57761906
11ELK1_19687146_ChIP-ChIP_HELA_Human2.51357253
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.50870106
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.47110446
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45825852
15IGF1R_20145208_ChIP-Seq_DFB_Human2.42738620
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39721738
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37703239
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34502571
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.27489139
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22910221
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18842568
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.16254128
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.10172595
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02100162
25TAF15_26573619_Chip-Seq_HEK293_Human2.01415775
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01385372
27P300_19829295_ChIP-Seq_ESCs_Human2.01355135
28FUS_26573619_Chip-Seq_HEK293_Human1.97340522
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.95756996
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95407743
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94217530
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89913726
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83804433
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.77965235
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76546097
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76045016
37BCAT_22108803_ChIP-Seq_LS180_Human1.71810923
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70593046
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.68704500
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.63300153
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62879103
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62154422
43EWS_26573619_Chip-Seq_HEK293_Human1.59979743
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57461367
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56941693
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55937419
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54976800
48TP53_22573176_ChIP-Seq_HFKS_Human1.53475306
49ER_23166858_ChIP-Seq_MCF-7_Human1.51964054
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50715788
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50608231
52IRF1_19129219_ChIP-ChIP_H3396_Human1.49493359
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47233583
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46922521
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.45673724
56* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45588326
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45524861
58CBP_20019798_ChIP-Seq_JUKART_Human1.45030619
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45030619
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44089815
61SOX17_20123909_ChIP-Seq_XEN_Mouse1.43741894
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41933118
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38887840
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37781832
65VDR_23849224_ChIP-Seq_CD4+_Human1.36551389
66* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35802147
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35507917
68MYC_18940864_ChIP-ChIP_HL60_Human1.35398326
69AR_21909140_ChIP-Seq_LNCAP_Human1.34700151
70NANOG_19829295_ChIP-Seq_ESCs_Human1.34036794
71SOX2_19829295_ChIP-Seq_ESCs_Human1.34036794
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33255851
73* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31760094
74STAT3_23295773_ChIP-Seq_U87_Human1.31661993
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.31009510
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.30367399
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30367399
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30286895
79SMAD4_21799915_ChIP-Seq_A2780_Human1.29947527
80* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29509675
81* STAT3_18555785_Chip-Seq_ESCs_Mouse1.28815483
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.28599152
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28292713
84* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27916312
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27420702
86* CRX_20693478_ChIP-Seq_RETINA_Mouse1.27150690
87AR_25329375_ChIP-Seq_VCAP_Human1.25797183
88* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25004734
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23850650
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23850650
91CJUN_26792858_Chip-Seq_BT549_Human1.23286277
92IRF8_22096565_ChIP-ChIP_GC-B_Human1.23226539
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23107207
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22948338
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22948087
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22501684
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.22473123
98* TCF4_22108803_ChIP-Seq_LS180_Human1.22164189
99* FOXP3_21729870_ChIP-Seq_TREG_Human1.20846596
100* EZH2_27294783_Chip-Seq_NPCs_Mouse1.20239373
101* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20200834
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19798766
103* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19635968
104* NFE2_27457419_Chip-Seq_LIVER_Mouse1.19092521
105* FLI1_27457419_Chip-Seq_LIVER_Mouse1.18486878
106DCP1A_22483619_ChIP-Seq_HELA_Human1.17851722
107* TCF4_23295773_ChIP-Seq_U87_Human1.17500566
108NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17359338
109* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16438358
110GATA1_22025678_ChIP-Seq_K562_Human1.16048913
111* P300_18555785_Chip-Seq_ESCs_Mouse1.15976616
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.15808881
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15517056
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.15278770
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15079811
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14696489
117AR_20517297_ChIP-Seq_VCAP_Human1.14254377
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14014051
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13309602
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13198399
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12582906
122* NMYC_18555785_Chip-Seq_ESCs_Mouse1.12349447
123* P53_22387025_ChIP-Seq_ESCs_Mouse1.12248169
124* CMYC_18555785_Chip-Seq_ESCs_Mouse1.12043434
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.11754840
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10999350
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10999350
128* NANOG_18555785_Chip-Seq_ESCs_Mouse1.09312226
129PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09223719
130SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08733703
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.07062082
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07036044
133* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06545557
134GBX2_23144817_ChIP-Seq_PC3_Human1.06141998
135GATA3_26560356_Chip-Seq_TH2_Human1.05407840
136CDX2_22108803_ChIP-Seq_LS180_Human1.04584429
137RUNX2_22187159_ChIP-Seq_PCA_Human1.04580781
138* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04351907
139NCOR_22424771_ChIP-Seq_293T_Human1.04266268
140STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03792184
141* E2F1_18555785_Chip-Seq_ESCs_Mouse1.03496422
142* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03453596
143* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03168714
144SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02317782
145GATA3_21878914_ChIP-Seq_MCF-7_Human1.02137060
146CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01169707
147SOX2_20726797_ChIP-Seq_SW620_Human1.01125562
148IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00065538
149* ZFX_18555785_Chip-Seq_ESCs_Mouse0.99808948
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.99248665
151NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97516631
152* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97088518
153SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95908243
154* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95733961
155* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95715385
156TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94951888
157* SOX2_18555785_Chip-Seq_ESCs_Mouse0.94650992
158* KLF4_18555785_Chip-Seq_ESCs_Mouse0.92981305
159* PU1_27457419_Chip-Seq_LIVER_Mouse0.91403299
160PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91156167
161BRD4_25478319_ChIP-Seq_HGPS_Human0.90952515
162SALL4_22934838_ChIP-ChIP_CD34+_Human0.89271515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.96950746
2MP0005503_abnormal_tendon_morphology4.11349376
3MP0005171_absent_coat_pigmentation3.88818842
4MP0008877_abnormal_DNA_methylation3.44971245
5MP0003950_abnormal_plasma_membrane2.86435672
6MP0002102_abnormal_ear_morphology2.79683010
7MP0000569_abnormal_digit_pigmentation2.68144169
8MP0006072_abnormal_retinal_apoptosis2.56452956
9MP0004134_abnormal_chest_morphology2.35317111
10MP0005275_abnormal_skin_tensile2.32224347
11MP0002938_white_spotting2.30323696
12MP0003136_yellow_coat_color2.26976362
13MP0005551_abnormal_eye_electrophysiolog2.25181374
14MP0005253_abnormal_eye_physiology2.23995437
15MP0002876_abnormal_thyroid_physiology2.09945729
16MP0002736_abnormal_nociception_after2.08162902
17MP0009697_abnormal_copulation2.07649709
18MP0000920_abnormal_myelination2.06574120
19MP0009384_cardiac_valve_regurgitation2.06391027
20MP0003279_aneurysm2.05234495
21MP0001958_emphysema1.98218635
22MP0006054_spinal_hemorrhage1.96137098
23MP0002653_abnormal_ependyma_morphology1.94619469
24MP0001542_abnormal_bone_strength1.94059773
25MP0003646_muscle_fatigue1.89413199
26MP0002295_abnormal_pulmonary_circulatio1.89371726
27MP0002837_dystrophic_cardiac_calcinosis1.87247102
28MP0001968_abnormal_touch/_nociception1.82565117
29MP0002933_joint_inflammation1.79800778
30MP0005408_hypopigmentation1.79305586
31MP0004272_abnormal_basement_membrane1.76827268
32MP0003011_delayed_dark_adaptation1.76460515
33MP0000427_abnormal_hair_cycle1.70686589
34MP0008875_abnormal_xenobiotic_pharmacok1.70083154
35MP0008872_abnormal_physiological_respon1.68616073
36MP0000372_irregular_coat_pigmentation1.68556882
37MP0001984_abnormal_olfaction1.66196460
38MP0003787_abnormal_imprinting1.62618230
39MP0006292_abnormal_olfactory_placode1.61237212
40MP0003806_abnormal_nucleotide_metabolis1.60337506
41MP0005389_reproductive_system_phenotype1.60092207
42MP0008057_abnormal_DNA_replication1.60026874
43MP0001919_abnormal_reproductive_system1.58979042
44MP0004142_abnormal_muscle_tone1.57529822
45MP0005508_abnormal_skeleton_morphology1.56891136
46MP0002928_abnormal_bile_duct1.56280682
47MP0000566_synostosis1.55335257
48MP0005671_abnormal_response_to1.54738545
49MP0009250_abnormal_appendicular_skeleto1.52001341
50MP0002132_abnormal_respiratory_system1.51096150
51MP0002638_abnormal_pupillary_reflex1.49113384
52MP0003186_abnormal_redox_activity1.48092656
53MP0010386_abnormal_urinary_bladder1.45630943
54MP0005451_abnormal_body_composition1.45622332
55MP0005645_abnormal_hypothalamus_physiol1.44500894
56MP0005084_abnormal_gallbladder_morpholo1.43269225
57MP0005257_abnormal_intraocular_pressure1.42044940
58MP0005646_abnormal_pituitary_gland1.41202208
59MP0001764_abnormal_homeostasis1.40229856
60MP0001501_abnormal_sleep_pattern1.36820949
61MP0008995_early_reproductive_senescence1.34374443
62MP0006276_abnormal_autonomic_nervous1.32051550
63MP0005174_abnormal_tail_pigmentation1.31114493
64MP0008058_abnormal_DNA_repair1.29508648
65MP0003724_increased_susceptibility_to1.29154149
66MP0008007_abnormal_cellular_replicative1.28952107
67MP0004133_heterotaxia1.28435157
68MP0003252_abnormal_bile_duct1.26720219
69MP0005075_abnormal_melanosome_morpholog1.25019177
70MP0004147_increased_porphyrin_level1.24868366
71MP0008789_abnormal_olfactory_epithelium1.23850327
72MP0005390_skeleton_phenotype1.21942762
73MP0002751_abnormal_autonomic_nervous1.20729142
74MP0002009_preneoplasia1.18044252
75MP0008932_abnormal_embryonic_tissue1.17325789
76MP0003937_abnormal_limbs/digits/tail_de1.16220035
77MP0001529_abnormal_vocalization1.15981458
78MP0010094_abnormal_chromosome_stability1.15120521
79MP0001299_abnormal_eye_distance/1.13231955
80MP0008260_abnormal_autophagy1.11951364
81MP0000163_abnormal_cartilage_morphology1.11343110
82MP0002148_abnormal_hypersensitivity_rea1.10509632
83MP0001243_abnormal_dermal_layer1.09965534
84MP0002133_abnormal_respiratory_system1.09610405
85MP0005388_respiratory_system_phenotype1.09610405
86MP0001986_abnormal_taste_sensitivity1.08143360
87MP0002108_abnormal_muscle_morphology1.07604134
88MP0001485_abnormal_pinna_reflex1.06786574
89MP0002998_abnormal_bone_remodeling1.06697423
90MP0009046_muscle_twitch1.05687765
91MP0001533_abnormal_skeleton_physiology1.05119212
92MP0002060_abnormal_skin_morphology1.04020663
93MP0000631_abnormal_neuroendocrine_gland1.03547377
94MP0001929_abnormal_gametogenesis1.02764451
95MP0005410_abnormal_fertilization1.02025129
96MP0002163_abnormal_gland_morphology1.01824639
97MP0001177_atelectasis1.00923781
98MP0005332_abnormal_amino_acid0.99719462
99MP0002210_abnormal_sex_determination0.99200213
100MP0005058_abnormal_lysosome_morphology0.98932136
101MP0005164_abnormal_response_to0.97693413
102MP0009745_abnormal_behavioral_response0.96609506
103MP0005220_abnormal_exocrine_pancreas0.96599315
104MP0000762_abnormal_tongue_morphology0.96469927
105MP0005623_abnormal_meninges_morphology0.95724436
106MP0002115_abnormal_skeleton_extremities0.95480106
107MP0001119_abnormal_female_reproductive0.95233894
108MP0002419_abnormal_innate_immunity0.95139141
109MP0000767_abnormal_smooth_muscle0.94922070
110MP0001293_anophthalmia0.94481735
111MP0002160_abnormal_reproductive_system0.94400265
112MP0001879_abnormal_lymphatic_vessel0.93127288
113MP0005310_abnormal_salivary_gland0.92884064
114MP0005379_endocrine/exocrine_gland_phen0.90947608
115MP0000653_abnormal_sex_gland0.89869780
116MP0002113_abnormal_skeleton_development0.89864557
117MP0003795_abnormal_bone_structure0.88986625
118MP0005195_abnormal_posterior_eye0.88889765
119MP0000015_abnormal_ear_pigmentation0.88881567
120MP0006082_CNS_inflammation0.88793290
121MP0002234_abnormal_pharynx_morphology0.87716001
122MP0004215_abnormal_myocardial_fiber0.87593470
123MP0002095_abnormal_skin_pigmentation0.87258046
124MP0003690_abnormal_glial_cell0.87032656
125MP0000613_abnormal_salivary_gland0.85834014
126MP0001188_hyperpigmentation0.85250581
127MP0000647_abnormal_sebaceous_gland0.85118517
128MP0005391_vision/eye_phenotype0.84710085
129MP0001873_stomach_inflammation0.84094898
130MP0002877_abnormal_melanocyte_morpholog0.82575899
131MP0002272_abnormal_nervous_system0.81949958
132MP0001486_abnormal_startle_reflex0.81698940
133MP0005409_darkened_coat_color0.80372268
134MP0001348_abnormal_lacrimal_gland0.80091760
135MP0010030_abnormal_orbit_morphology0.79700906
136MP0009333_abnormal_splenocyte_physiolog0.78799461
137MP0000230_abnormal_systemic_arterial0.78695247
138MP0002109_abnormal_limb_morphology0.78138119
139MP0001324_abnormal_eye_pigmentation0.77860412
140MP0003786_premature_aging0.77808788
141MP0002396_abnormal_hematopoietic_system0.77748574
142MP0003077_abnormal_cell_cycle0.77522683
143MP0001800_abnormal_humoral_immune0.77510445
144MP0002282_abnormal_trachea_morphology0.76419667
145MP0001145_abnormal_male_reproductive0.75538566
146MP0001175_abnormal_lung_morphology0.75316187
147MP0004782_abnormal_surfactant_physiolog0.75104261
148MP0003195_calcinosis0.74941127
149MP0002138_abnormal_hepatobiliary_system0.74186796
150MP0005085_abnormal_gallbladder_physiolo0.73820867
151MP0009785_altered_susceptibility_to0.73777563
152MP0002177_abnormal_outer_ear0.73535505
153MP0000383_abnormal_hair_follicle0.73192036
154MP0003448_altered_tumor_morphology0.73097745
155MP0004043_abnormal_pH_regulation0.73084291
156MP0002277_abnormal_respiratory_mucosa0.72884415
157MP0004145_abnormal_muscle_electrophysio0.72714908
158MP0000343_altered_response_to0.72019286
159MP0005023_abnormal_wound_healing0.72015565
160MP0001663_abnormal_digestive_system0.71999459
161MP0000049_abnormal_middle_ear0.71464219
162MP0002111_abnormal_tail_morphology0.71192844
163MP0003698_abnormal_male_reproductive0.70818922
164MP0005167_abnormal_blood-brain_barrier0.70259169
165MP0003718_maternal_effect0.69798072
166MP0000681_abnormal_thyroid_gland0.69449485
167MP0003755_abnormal_palate_morphology0.67274215
168MP0005367_renal/urinary_system_phenotyp0.66985122
169MP0000516_abnormal_urinary_system0.66985122
170MP0010368_abnormal_lymphatic_system0.66535570
171MP0000432_abnormal_head_morphology0.65440005
172MP0009764_decreased_sensitivity_to0.65432798

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.30379344
2Premature rupture of membranes (HP:0001788)4.24233751
3Abnormality of midbrain morphology (HP:0002418)4.17559539
4Molar tooth sign on MRI (HP:0002419)4.17559539
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.03998063
6Chromsome breakage (HP:0040012)3.97093975
7True hermaphroditism (HP:0010459)3.78138737
8Pancreatic fibrosis (HP:0100732)3.65428742
9Nephronophthisis (HP:0000090)3.37359159
10Congenital stationary night blindness (HP:0007642)3.28630624
11Abnormality of the renal cortex (HP:0011035)3.18736286
12Medial flaring of the eyebrow (HP:0010747)3.12653366
13Irregular epiphyses (HP:0010582)3.07428412
14Abolished electroretinogram (ERG) (HP:0000550)3.04822975
15Duplicated collecting system (HP:0000081)2.96943727
16Soft skin (HP:0000977)2.96292700
17Abnormality of the renal medulla (HP:0100957)2.96135698
18Patchy hypopigmentation of hair (HP:0011365)2.93577836
19Type II lissencephaly (HP:0007260)2.84960441
20Epiphyseal dysplasia (HP:0002656)2.81933290
21Vertebral compression fractures (HP:0002953)2.80100639
22Renal cortical cysts (HP:0000803)2.78468729
23White forelock (HP:0002211)2.76429450
24Attenuation of retinal blood vessels (HP:0007843)2.75946144
25Chronic hepatic failure (HP:0100626)2.71986077
26Congenital sensorineural hearing impairment (HP:0008527)2.68646032
27Wormian bones (HP:0002645)2.68112187
28Bile duct proliferation (HP:0001408)2.66391434
29Abnormal biliary tract physiology (HP:0012439)2.66391434
30Protrusio acetabuli (HP:0003179)2.64961340
31Flat capital femoral epiphysis (HP:0003370)2.59072267
32Abnormality of the renal collecting system (HP:0004742)2.55186305
33Parakeratosis (HP:0001036)2.54049822
34Adrenal hypoplasia (HP:0000835)2.53675433
35Type I transferrin isoform profile (HP:0003642)2.53369647
36Tubular atrophy (HP:0000092)2.51914809
37Increased CSF lactate (HP:0002490)2.48618545
38Abnormal rod and cone electroretinograms (HP:0008323)2.47402195
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.46675922
40Stomatitis (HP:0010280)2.46567620
41Pendular nystagmus (HP:0012043)2.45924867
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.45695151
43Congenital primary aphakia (HP:0007707)2.44251428
44Beaking of vertebral bodies (HP:0004568)2.43574629
45Acute necrotizing encephalopathy (HP:0006965)2.42657599
46Large for gestational age (HP:0001520)2.42355706
47Mitochondrial inheritance (HP:0001427)2.40279841
48Methylmalonic acidemia (HP:0002912)2.38472190
49Congenital, generalized hypertrichosis (HP:0004540)2.37572564
50Cystic liver disease (HP:0006706)2.37310877
51Gait imbalance (HP:0002141)2.36836319
52Aortic dissection (HP:0002647)2.35065589
53Small epiphyses (HP:0010585)2.34883396
54Osteolytic defects of the hand bones (HP:0009699)2.33329780
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.33329780
56Cervical subluxation (HP:0003308)2.31063008
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.29575153
58Abnormality of dentin (HP:0010299)2.29357636
59Hypothermia (HP:0002045)2.28061405
60Vacuolated lymphocytes (HP:0001922)2.26929815
61Nephrogenic diabetes insipidus (HP:0009806)2.26329324
62Keratoconus (HP:0000563)2.24428289
63Increased corneal curvature (HP:0100692)2.24428289
64Neonatal short-limb short stature (HP:0008921)2.24213789
65Absent/shortened dynein arms (HP:0200106)2.24207724
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.24207724
67Progressive macrocephaly (HP:0004481)2.22589279
68Submucous cleft hard palate (HP:0000176)2.22294109
69Cerebral hypomyelination (HP:0006808)2.22242604
70Delayed cranial suture closure (HP:0000270)2.21767955
71Hyperventilation (HP:0002883)2.20413917
72Male pseudohermaphroditism (HP:0000037)2.19571564
73Abnormality of alanine metabolism (HP:0010916)2.19391270
74Hyperalaninemia (HP:0003348)2.19391270
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19391270
76Thyroiditis (HP:0100646)2.18871638
77Acute encephalopathy (HP:0006846)2.18439076
78Colon cancer (HP:0003003)2.17844530
79Disproportionate short-trunk short stature (HP:0003521)2.17727939
80Short tibia (HP:0005736)2.16280921
81Stomach cancer (HP:0012126)2.14869095
82Polydipsia (HP:0001959)2.13497853
83Abnormal drinking behavior (HP:0030082)2.13497853
84Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13132952
85Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.12507870
86Absent epiphyses (HP:0010577)2.12507870
87Sclerocornea (HP:0000647)2.12425910
88Decreased central vision (HP:0007663)2.11135202
89Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09673877
90Hypoplasia of the odontoid process (HP:0003311)2.08232828
91Gaze-evoked nystagmus (HP:0000640)2.07675730
92Autoamputation (HP:0001218)2.06451194
93Lipid accumulation in hepatocytes (HP:0006561)2.06415421
94Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04664967
95IgG deficiency (HP:0004315)2.03367875
96Abnormal protein glycosylation (HP:0012346)2.02528021
97Abnormal glycosylation (HP:0012345)2.02528021
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02528021
99Abnormal protein N-linked glycosylation (HP:0012347)2.02528021
100Follicular hyperkeratosis (HP:0007502)2.02140315
101Renal Fanconi syndrome (HP:0001994)2.00755475
102Methylmalonic aciduria (HP:0012120)1.98897641
103Hepatocellular necrosis (HP:0001404)1.98244350
104Aplasia/hypoplasia of the uterus (HP:0008684)1.96683263
105Genital tract atresia (HP:0001827)1.96436025
106Congenital hepatic fibrosis (HP:0002612)1.96208691
107Flared iliac wings (HP:0002869)1.95926859
108Hepatic necrosis (HP:0002605)1.95059791
109Furrowed tongue (HP:0000221)1.94812318
110Progressive inability to walk (HP:0002505)1.94731244
111Reduced antithrombin III activity (HP:0001976)1.94144943
112Duplication of thumb phalanx (HP:0009942)1.94014337
113Broad-based gait (HP:0002136)1.93514989
114Severe muscular hypotonia (HP:0006829)1.93451627
115Constricted visual fields (HP:0001133)1.92874383
116Aplasia/Hypoplasia of the spleen (HP:0010451)1.92242341
117Hepatosplenomegaly (HP:0001433)1.91413506
118Delayed closure of the anterior fontanelle (HP:0001476)1.91299993
119Hypergonadotropic hypogonadism (HP:0000815)1.90145572
120Inability to walk (HP:0002540)1.90053875
121Delayed epiphyseal ossification (HP:0002663)1.89899215
122Bony spicule pigmentary retinopathy (HP:0007737)1.89701336
123Abnormality of macular pigmentation (HP:0008002)1.89649319
124Vaginal atresia (HP:0000148)1.88361127
125Bell-shaped thorax (HP:0001591)1.87776716
126Blue sclerae (HP:0000592)1.87025702
127Biconcave vertebral bodies (HP:0004586)1.86949140
128Postaxial foot polydactyly (HP:0001830)1.86587129
129Anencephaly (HP:0002323)1.85976694
130Abnormal auditory evoked potentials (HP:0006958)1.85373778
1313-Methylglutaconic aciduria (HP:0003535)1.84982163
132Infantile muscular hypotonia (HP:0008947)1.84356501
133Lissencephaly (HP:0001339)1.83873420
134Abnormal mitochondria in muscle tissue (HP:0008316)1.83653423
135Nonimmune hydrops fetalis (HP:0001790)1.83335095
136Increased serum lactate (HP:0002151)1.82251623
137Barrel-shaped chest (HP:0001552)1.81514682
138Abnormality of the odontoid process (HP:0003310)1.81342598
139Meckel diverticulum (HP:0002245)1.80923674
140Asplenia (HP:0001746)1.80811027
141Poor head control (HP:0002421)1.80039410
142Optic disc pallor (HP:0000543)1.79116762
143Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78418565
144Degeneration of the lateral corticospinal tracts (HP:0002314)1.78418565
145Adactyly (HP:0009776)1.77918706
146Abnormality of incisor morphology (HP:0011063)1.77502035
147Cerebellar dysplasia (HP:0007033)1.76923178
148Abnormality of the femoral head (HP:0003368)1.76575140
149Spondylolisthesis (HP:0003302)1.76312524
150Abnormality of the labia minora (HP:0012880)1.76024703
151Recurrent pneumonia (HP:0006532)1.75826932
152Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74656937
153Abnormality of the pons (HP:0007361)1.74593657
154Supernumerary spleens (HP:0009799)1.74512174
155Abnormality of chromosome stability (HP:0003220)1.73811822
15611 pairs of ribs (HP:0000878)1.73071877
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.72226377
158Irregular vertebral endplates (HP:0003301)1.72115796
159Prolonged neonatal jaundice (HP:0006579)1.71743528
160Opisthotonus (HP:0002179)1.71429645
161Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71221283
162Vascular tortuosity (HP:0004948)1.69795277
163Pulmonary artery stenosis (HP:0004415)1.69352106
164Broad face (HP:0000283)1.69307743
165Clubbing of toes (HP:0100760)1.68947684
166Platyspondyly (HP:0000926)1.66782754
167Hypoplastic pelvis (HP:0008839)1.66270675
168Peritonitis (HP:0002586)1.65909618
169Hypoplasia of the iris (HP:0007676)1.65144090
170Abnormality of the ileum (HP:0001549)1.64750462
171Aortic valve stenosis (HP:0001650)1.64258962
172Abnormal foot bone ossification (HP:0010675)1.63816051
173Ectopic kidney (HP:0000086)1.63542972
174Aplasia of the musculature (HP:0100854)1.63356632
175Sensory axonal neuropathy (HP:0003390)1.63249151
176Increased hepatocellular lipid droplets (HP:0006565)1.62638910
177Reticulocytopenia (HP:0001896)1.61025030
178Mesomelia (HP:0003027)1.60883090
179Glossoptosis (HP:0000162)1.59740224
180Metaphyseal irregularity (HP:0003025)1.58462723
181Anhidrosis (HP:0000970)1.58091395
182Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.57627328
183Abnormality of femoral epiphyses (HP:0006499)1.57627328
184Atrophic scars (HP:0001075)1.57015446
185Abnormality of the epiphysis of the femoral head (HP:0010574)1.56844215
186Stillbirth (HP:0003826)1.56440832
187Abnormality of carpal bone ossification (HP:0006257)1.55260708
188Congenital ichthyosiform erythroderma (HP:0007431)1.53634599
189Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.52830408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK392.94697597
2ZAK2.77958647
3PBK2.74916435
4MAP4K22.68833436
5IRAK32.58709587
6WNK32.55722375
7ACVR1B2.39371732
8TAOK32.25242508
9BUB12.12835140
10MKNK12.10947902
11BCR1.98933523
12EIF2AK31.91739135
13TIE11.88806260
14NME21.86464206
15MAPKAPK51.84068751
16EIF2AK11.76472452
17STK161.73948290
18NEK61.71400746
19MST41.71284193
20TLK11.71172706
21IRAK41.66508313
22TRPM71.63142305
23EIF2AK21.59011147
24CLK11.55128162
25PKN11.49045203
26PINK11.48879234
27PIM21.47665204
28LIMK11.47071796
29TRIM281.46885682
30VRK11.46070262
31BMPR1B1.44072156
32EPHB11.43656871
33MUSK1.43568224
34AKT31.43483474
35NUAK11.43164233
36MAP3K41.42522243
37OXSR11.40149038
38YES11.35698028
39MAP3K141.35463234
40NEK91.33964182
41MKNK21.28849178
42CASK1.28303343
43WNK41.25295204
44STK38L1.19623364
45MET1.19599572
46PLK41.19304620
47TESK21.15958149
48STK41.07804464
49WNK11.07268241
50CDK81.05599080
51MAPK131.03165564
52ERBB31.03151189
53PIK3CG1.02356936
54TGFBR11.00630137
55RPS6KA51.00346978
56INSRR0.99908296
57DDR20.99246774
58SRPK10.96793756
59PRPF4B0.96542590
60PASK0.93764596
61VRK20.88894383
62IRAK20.88579266
63BRSK20.86517741
64PLK30.84205022
65TEC0.84001349
66MAP3K30.83619336
67ADRBK10.82140237
68FRK0.81982025
69TAOK10.81021662
70CSNK1A1L0.80640956
71PAK30.80636794
72TNIK0.79804255
73IKBKB0.79707054
74ADRBK20.77524059
75TGFBR20.76627057
76STK30.74419482
77GRK70.73857018
78MOS0.73690417
79EPHA30.72838183
80EPHA20.71962330
81MAP3K120.71940676
82BCKDK0.70489386
83CSNK1G30.70150490
84CHEK20.70021136
85TXK0.68516086
86AURKA0.67420364
87DYRK20.67319327
88PRKCQ0.66296508
89AURKB0.65751461
90IRAK10.64677916
91CSNK1G20.63951767
92DYRK1A0.63391402
93DAPK20.63088193
94TTK0.62842300
95ATR0.61997213
96PIK3CA0.59997561
97ITK0.59066322
98PTK2B0.58836912
99PNCK0.58422127
100NLK0.57659932
101MAPKAPK20.56102603
102PAK20.56089704
103CAMKK20.55445980
104BMPR20.55443537
105TSSK60.55168269
106PRKCE0.55022552
107WEE10.54699455
108GRK10.53996739
109CDK70.53856922
110PLK10.53845416
111PDK20.53304719
112TAF10.52575717
113CSNK1G10.52404200
114MAP2K70.52216969
115PLK20.51035107
116PRKCG0.49029845
117GRK50.48332168
118MAP2K60.48158213
119CDC70.47308668
120ABL20.46252777
121OBSCN0.46211587
122STK240.44677679
123TESK10.44442577
124RPS6KA40.43844614
125PRKG20.43379758
126FGFR20.42865685
127IKBKE0.42664457
128BRAF0.42504521
129KIT0.42127071
130IGF1R0.42115577
131TNK20.41809866
132CSNK2A10.41527393
133ERBB40.40190671
134LYN0.39833641
135JAK30.39388885
136CAMK2D0.39214690
137CSF1R0.38003217
138ROCK20.37544966
139PHKG10.36676931
140PHKG20.36676931
141FER0.35958655
142ABL10.35608173
143CSNK1A10.34550277
144PRKACA0.34300466
145MAPKAPK30.34276927
146NME10.33865069

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.93912580
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.90822258
3Steroid biosynthesis_Homo sapiens_hsa001003.51841698
4Fatty acid elongation_Homo sapiens_hsa000622.55168430
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49274020
6Non-homologous end-joining_Homo sapiens_hsa034502.30097545
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09816375
8Butanoate metabolism_Homo sapiens_hsa006502.04702438
9DNA replication_Homo sapiens_hsa030302.00608577
10Mismatch repair_Homo sapiens_hsa034301.98085819
11Phototransduction_Homo sapiens_hsa047441.91487457
12Sphingolipid metabolism_Homo sapiens_hsa006001.87097957
13RNA polymerase_Homo sapiens_hsa030201.86396449
14Sulfur metabolism_Homo sapiens_hsa009201.85258044
15Proteasome_Homo sapiens_hsa030501.81544008
16Homologous recombination_Homo sapiens_hsa034401.77787723
17Fanconi anemia pathway_Homo sapiens_hsa034601.73580030
18Propanoate metabolism_Homo sapiens_hsa006401.67105812
19Nucleotide excision repair_Homo sapiens_hsa034201.66853747
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62892782
21Ether lipid metabolism_Homo sapiens_hsa005651.62648429
22Tryptophan metabolism_Homo sapiens_hsa003801.57130503
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54122632
24Nitrogen metabolism_Homo sapiens_hsa009101.53652428
25Basal transcription factors_Homo sapiens_hsa030221.53544005
26Malaria_Homo sapiens_hsa051441.50092180
27Ribosome_Homo sapiens_hsa030101.49544231
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49466691
29Caffeine metabolism_Homo sapiens_hsa002321.43789797
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.42331027
31Selenocompound metabolism_Homo sapiens_hsa004501.40592400
32Other glycan degradation_Homo sapiens_hsa005111.40212679
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39299748
34Arachidonic acid metabolism_Homo sapiens_hsa005901.39150846
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38201424
36ECM-receptor interaction_Homo sapiens_hsa045121.37931631
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34002454
38Base excision repair_Homo sapiens_hsa034101.32656153
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32507561
40Primary immunodeficiency_Homo sapiens_hsa053401.31886107
41Cell cycle_Homo sapiens_hsa041101.22426780
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19057902
43Folate biosynthesis_Homo sapiens_hsa007901.19022958
44Pyrimidine metabolism_Homo sapiens_hsa002401.18967743
45Huntingtons disease_Homo sapiens_hsa050161.18506398
46Chemical carcinogenesis_Homo sapiens_hsa052041.18331885
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18040485
48One carbon pool by folate_Homo sapiens_hsa006701.16060960
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15851857
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15604593
51Autoimmune thyroid disease_Homo sapiens_hsa053201.14498388
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09371725
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06762782
54Retinol metabolism_Homo sapiens_hsa008301.04977356
55Regulation of autophagy_Homo sapiens_hsa041401.04020948
56Allograft rejection_Homo sapiens_hsa053301.03582685
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03082274
58Spliceosome_Homo sapiens_hsa030401.00963865
59Alzheimers disease_Homo sapiens_hsa050101.00819762
60Graft-versus-host disease_Homo sapiens_hsa053320.99261240
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97438980
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95952618
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95757316
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95610510
65Rheumatoid arthritis_Homo sapiens_hsa053230.95473693
66Vitamin B6 metabolism_Homo sapiens_hsa007500.94165343
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.93553625
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92822059
69Linoleic acid metabolism_Homo sapiens_hsa005910.92749893
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.92508963
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91999027
72Phagosome_Homo sapiens_hsa041450.91593899
73RNA degradation_Homo sapiens_hsa030180.91032395
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.91023358
75Lysosome_Homo sapiens_hsa041420.88714135
76beta-Alanine metabolism_Homo sapiens_hsa004100.88497188
77N-Glycan biosynthesis_Homo sapiens_hsa005100.87547438
78Taste transduction_Homo sapiens_hsa047420.86615428
79Glutathione metabolism_Homo sapiens_hsa004800.86558174
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85646963
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83552852
82Olfactory transduction_Homo sapiens_hsa047400.80097534
83Purine metabolism_Homo sapiens_hsa002300.79049250
84Collecting duct acid secretion_Homo sapiens_hsa049660.77541641
85Arginine and proline metabolism_Homo sapiens_hsa003300.77033427
86Protein digestion and absorption_Homo sapiens_hsa049740.76589177
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76197925
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75987977
89Hematopoietic cell lineage_Homo sapiens_hsa046400.73998370
90ABC transporters_Homo sapiens_hsa020100.73593254
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72210148
92Legionellosis_Homo sapiens_hsa051340.71218613
93RNA transport_Homo sapiens_hsa030130.66848145
94Glycerolipid metabolism_Homo sapiens_hsa005610.65123189
95Vitamin digestion and absorption_Homo sapiens_hsa049770.64222117
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64171486
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62686269
98TGF-beta signaling pathway_Homo sapiens_hsa043500.61580627
99Systemic lupus erythematosus_Homo sapiens_hsa053220.61502369
100Asthma_Homo sapiens_hsa053100.60241950
101p53 signaling pathway_Homo sapiens_hsa041150.58832197
102Fatty acid degradation_Homo sapiens_hsa000710.58777992
103Fatty acid metabolism_Homo sapiens_hsa012120.56815241
104Circadian rhythm_Homo sapiens_hsa047100.55347833
105Histidine metabolism_Homo sapiens_hsa003400.55193009
106Cardiac muscle contraction_Homo sapiens_hsa042600.54574849
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.51778371
108Nicotine addiction_Homo sapiens_hsa050330.51631741
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51536348
110Mineral absorption_Homo sapiens_hsa049780.51214968
111Oxidative phosphorylation_Homo sapiens_hsa001900.50965543
112Small cell lung cancer_Homo sapiens_hsa052220.50654192
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.50640865
114Metabolic pathways_Homo sapiens_hsa011000.49888369
115Measles_Homo sapiens_hsa051620.47984857
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47961077
117Epstein-Barr virus infection_Homo sapiens_hsa051690.47505250
118Pertussis_Homo sapiens_hsa051330.45583371
119Type I diabetes mellitus_Homo sapiens_hsa049400.45579191
120Leishmaniasis_Homo sapiens_hsa051400.43857556
121Antigen processing and presentation_Homo sapiens_hsa046120.43729167
122Fat digestion and absorption_Homo sapiens_hsa049750.42856581
123Vibrio cholerae infection_Homo sapiens_hsa051100.42459407
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41177569
125Herpes simplex infection_Homo sapiens_hsa051680.40465671
126Peroxisome_Homo sapiens_hsa041460.40439191
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39824572
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38908400
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.38704374
130Shigellosis_Homo sapiens_hsa051310.38208843
131MicroRNAs in cancer_Homo sapiens_hsa052060.37610700
132Prostate cancer_Homo sapiens_hsa052150.37195024
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36629094
134Ovarian steroidogenesis_Homo sapiens_hsa049130.36124647
135Viral carcinogenesis_Homo sapiens_hsa052030.35140796
136Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33616312
137Focal adhesion_Homo sapiens_hsa045100.32425105
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.28310506
139Parkinsons disease_Homo sapiens_hsa050120.28233935
140Apoptosis_Homo sapiens_hsa042100.27884016
141Basal cell carcinoma_Homo sapiens_hsa052170.26796812

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