ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glucocorticoid biosynthetic process (GO:0006704)	5.18470475
2	estrogen biosynthetic process (GO:0006703)	5.04924358
3	androgen biosynthetic process (GO:0006702)	5.04485456
4	exogenous drug catabolic process (GO:0042738)	4.75719517
5	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	4.67611745
6	drug catabolic process (GO:0042737)	4.57800427
7	benzene-containing compound metabolic process (GO:0042537)	4.55379729
8	indole-containing compound catabolic process (GO:0042436)	4.50921690
9	indolalkylamine catabolic process (GO:0046218)	4.50921690
10	tryptophan catabolic process (GO:0006569)	4.50921690
11	regulation of protein activation cascade (GO:2000257)	4.35629800
12	glucocorticoid metabolic process (GO:0008211)	4.26926970
13	aromatic amino acid family catabolic process (GO:0009074)	4.19718621
14	regulation of complement activation (GO:0030449)	4.17525502
15	complement activation, alternative pathway (GO:0006957)	4.13621279
16	tryptophan metabolic process (GO:0006568)	4.12969155
17	high-density lipoprotein particle remodeling (GO:0034375)	4.07249611
18	epoxygenase P450 pathway (GO:0019373)	3.94059896
19	indolalkylamine metabolic process (GO:0006586)	3.93641262
20	reverse cholesterol transport (GO:0043691)	3.92279037
21	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.84615169
22	L-phenylalanine catabolic process (GO:0006559)	3.84615169
23	response to follicle-stimulating hormone (GO:0032354)	3.79647560
24	glyoxylate metabolic process (GO:0046487)	3.79593131
25	C21-steroid hormone biosynthetic process (GO:0006700)	3.79524912
26	omega-hydroxylase P450 pathway (GO:0097267)	3.74808952
27	bile acid biosynthetic process (GO:0006699)	3.68892206
28	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.65875790
29	S-adenosylmethionine metabolic process (GO:0046500)	3.63564561
30	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.60902318
31	protein-lipid complex remodeling (GO:0034368)	3.58197352
32	macromolecular complex remodeling (GO:0034367)	3.58197352
33	plasma lipoprotein particle remodeling (GO:0034369)	3.58197352
34	progesterone metabolic process (GO:0042448)	3.56666185
35	hormone biosynthetic process (GO:0042446)	3.50578374
36	regulation of triglyceride catabolic process (GO:0010896)	3.47173111
37	oxidative demethylation (GO:0070989)	3.43753379
38	triglyceride homeostasis (GO:0070328)	3.43401365
39	acylglycerol homeostasis (GO:0055090)	3.43401365
40	serine family amino acid catabolic process (GO:0009071)	3.39328583
41	kynurenine metabolic process (GO:0070189)	3.37471481
42	mannosylation (GO:0097502)	3.36505847
43	bile acid metabolic process (GO:0008206)	3.36035746
44	cellular ketone body metabolic process (GO:0046950)	3.35643193
45	cellular response to gonadotropin stimulus (GO:0071371)	3.33034482
46	regulation of fibrinolysis (GO:0051917)	3.32777450
47	drug metabolic process (GO:0017144)	3.25050909
48	cholesterol efflux (GO:0033344)	3.24992471
49	piRNA metabolic process (GO:0034587)	3.22723421
50	aromatic amino acid family metabolic process (GO:0009072)	3.22148043
51	uronic acid metabolic process (GO:0006063)	3.21594226
52	glucuronate metabolic process (GO:0019585)	3.21594226
53	C21-steroid hormone metabolic process (GO:0008207)	3.21576301
54	cellular glucuronidation (GO:0052695)	3.18373207
55	intestinal cholesterol absorption (GO:0030299)	3.17135054
56	cellular response to cadmium ion (GO:0071276)	3.17013699
57	dopamine transport (GO:0015872)	3.15342132
58	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.15036351
59	ketone biosynthetic process (GO:0042181)	3.12201527
60	ketone body metabolic process (GO:1902224)	3.11319178
61	negative regulation of cAMP-mediated signaling (GO:0043951)	3.11153994
62	cellular biogenic amine catabolic process (GO:0042402)	3.08001073
63	amine catabolic process (GO:0009310)	3.08001073
64	DNA deamination (GO:0045006)	3.07864480
65	cellular response to antibiotic (GO:0071236)	3.05736658
66	detection of light stimulus involved in visual perception (GO:0050908)	3.05488069
67	detection of light stimulus involved in sensory perception (GO:0050962)	3.05488069
68	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.05342725
69	L-phenylalanine metabolic process (GO:0006558)	3.05342725
70	negative regulation of protein activation cascade (GO:2000258)	3.02443500
71	androgen metabolic process (GO:0008209)	2.98438106
72	regulation of acrosome reaction (GO:0060046)	2.98013061
73	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97641093
74	response to insecticide (GO:0017085)	2.97120697
75	amino-acid betaine metabolic process (GO:0006577)	2.94055707
76	arginine metabolic process (GO:0006525)	2.94030848
77	steroid catabolic process (GO:0006706)	2.93960197
78	L-methionine salvage (GO:0071267)	2.91351505
79	L-methionine biosynthetic process (GO:0071265)	2.91351505
80	amino acid salvage (GO:0043102)	2.91351505
81	negative regulation of fibrinolysis (GO:0051918)	2.89252804
82	cysteine metabolic process (GO:0006534)	2.87373962
83	blood coagulation, intrinsic pathway (GO:0007597)	2.85193856
84	toxin metabolic process (GO:0009404)	2.85035537
85	water-soluble vitamin biosynthetic process (GO:0042364)	2.84400806
86	plasma lipoprotein particle organization (GO:0071827)	2.83308590
87	plasma lipoprotein particle clearance (GO:0034381)	2.82644933
88	behavioral response to nicotine (GO:0035095)	2.81217215
89	alpha-amino acid catabolic process (GO:1901606)	2.80470593
90	alkaloid metabolic process (GO:0009820)	2.77620435
91	cellular response to toxic substance (GO:0097237)	2.76612603
92	regulation of glucokinase activity (GO:0033131)	2.75164913
93	regulation of hexokinase activity (GO:1903299)	2.75164913
94	sterol transport (GO:0015918)	2.75155315
95	cholesterol transport (GO:0030301)	2.75155315
96	behavioral response to ethanol (GO:0048149)	2.74702228
97	drug transmembrane transport (GO:0006855)	2.74566378
98	cellular ketone metabolic process (GO:0042180)	2.73978748
99	protein carboxylation (GO:0018214)	2.73166536
100	peptidyl-glutamic acid carboxylation (GO:0017187)	2.73166536

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.61129949
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.34359452
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.13317876
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.98645393
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.77280668
6	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.66154861
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48609960
8	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.38366720
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35710655
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.26572973
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.13225425
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.08420583
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.07504500
14	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.04637297
15	BCAT_22108803_ChIP-Seq_LS180_Human	1.99602641
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.93383046
17	IRF1_19129219_ChIP-ChIP_H3396_Human	1.92801609
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85156620
19	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.79969564
20	FUS_26573619_Chip-Seq_HEK293_Human	1.78063854
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.77758513
22	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.75811159
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72214164
24	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.71559039
25	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.69497138
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.65782504
27	P300_19829295_ChIP-Seq_ESCs_Human	1.63314911
28	TCF4_22108803_ChIP-Seq_LS180_Human	1.61920365
29	EWS_26573619_Chip-Seq_HEK293_Human	1.60975886
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.59763552
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52976892
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.52793302
33	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.52667555
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.50111359
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48992671
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.48992671
37	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.48430937
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.45999075
39	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.44699375
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44503454
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42117083
42	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.42004713
43	TCF4_23295773_ChIP-Seq_U87_Human	1.41497687
44	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.37846780
45	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.37572381
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37085566
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35910710
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35910710
49	HTT_18923047_ChIP-ChIP_STHdh_Human	1.35877428
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.34534740
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.33712091
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33694837
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33650887
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33518463
55	STAT3_23295773_ChIP-Seq_U87_Human	1.31985946
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30384841
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30384841
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30197882
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26377234
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25842651
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.25842651
62	AR_25329375_ChIP-Seq_VCAP_Human	1.25296714
63	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.24701797
64	NCOR_22424771_ChIP-Seq_293T_Human	1.24390984
65	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.23537321
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22025977
67	CDX2_22108803_ChIP-Seq_LS180_Human	1.21788170
68	SMAD4_21799915_ChIP-Seq_A2780_Human	1.21495240
69	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.20747527
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18828540
71	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.18571754
72	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16881934
73	AR_20517297_ChIP-Seq_VCAP_Human	1.15880990
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15645085
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15562029
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15009439
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14773604
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14766915
79	MYC_19829295_ChIP-Seq_ESCs_Human	1.13859464
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13012947
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12899642
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.12323295
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11591152
84	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.08845296
85	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.08756571
86	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.05738074
87	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.04113672
88	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.02538027
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02523622
90	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01834843
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01610757
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01575024
93	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.00979584
94	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00491401
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99917329
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.99734577
97	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98253330
98	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98056923
99	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.97944147
100	CEBPB_22108803_ChIP-Seq_LS180_Human	0.96575705

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.27890488
2	MP0008875_abnormal_xenobiotic_pharmacok	3.89692367
3	MP0002139_abnormal_hepatobiliary_system	3.73468970
4	MP0005360_urolithiasis	3.33789599
5	MP0005085_abnormal_gallbladder_physiolo	2.97260662
6	MP0002876_abnormal_thyroid_physiology	2.89094140
7	MP0005365_abnormal_bile_salt	2.84544295
8	MP0008877_abnormal_DNA_methylation	2.61949607
9	MP0003252_abnormal_bile_duct	2.42742821
10	MP0003136_yellow_coat_color	2.40656235
11	MP0002102_abnormal_ear_morphology	2.15288158
12	MP0000639_abnormal_adrenal_gland	2.15066336
13	MP0005551_abnormal_eye_electrophysiolog	2.14284567
14	MP0000372_irregular_coat_pigmentation	2.12658543
15	MP0002909_abnormal_adrenal_gland	2.07746965
16	MP0010329_abnormal_lipoprotein_level	2.01747552
17	MP0002138_abnormal_hepatobiliary_system	1.99239779
18	MP0000013_abnormal_adipose_tissue	1.95203179
19	MP0005646_abnormal_pituitary_gland	1.84092585
20	MP0001968_abnormal_touch/_nociception	1.78665070
21	MP0005645_abnormal_hypothalamus_physiol	1.75805054
22	MP0001764_abnormal_homeostasis	1.70755651
23	MP0009780_abnormal_chondrocyte_physiolo	1.68746640
24	MP0008995_early_reproductive_senescence	1.66874904
25	MP0005332_abnormal_amino_acid	1.59895813
26	MP0006292_abnormal_olfactory_placode	1.55737823
27	MP0003122_maternal_imprinting	1.55701059
28	MP0001986_abnormal_taste_sensitivity	1.55586653
29	MP0003011_delayed_dark_adaptation	1.49563923
30	MP0008872_abnormal_physiological_respon	1.48712680
31	MP0001984_abnormal_olfaction	1.47743584
32	MP0002638_abnormal_pupillary_reflex	1.47713662
33	MP0005253_abnormal_eye_physiology	1.46478211
34	MP0003880_abnormal_central_pattern	1.43572962
35	MP0004142_abnormal_muscle_tone	1.43453336
36	MP0002837_dystrophic_cardiac_calcinosis	1.41760791
37	MP0010368_abnormal_lymphatic_system	1.40695981
38	MP0006035_abnormal_mitochondrial_morpho	1.30755933
39	MP0006072_abnormal_retinal_apoptosis	1.30582258
40	MP0001529_abnormal_vocalization	1.28649502
41	MP0004043_abnormal_pH_regulation	1.24297533
42	MP0009697_abnormal_copulation	1.22342614
43	MP0006276_abnormal_autonomic_nervous	1.19908066
44	MP0003868_abnormal_feces_composition	1.18432084
45	MP0002938_white_spotting	1.18057949
46	MP0009046_muscle_twitch	1.17411414
47	MP0001485_abnormal_pinna_reflex	1.16944331
48	MP0001486_abnormal_startle_reflex	1.14056633
49	MP0003786_premature_aging	1.13035052
50	MP0009745_abnormal_behavioral_response	1.10859910
51	MP0006036_abnormal_mitochondrial_physio	1.10849885
52	MP0003121_genomic_imprinting	1.09452993
53	MP0005389_reproductive_system_phenotype	1.09370668
54	MP0005636_abnormal_mineral_homeostasis	1.09367570
55	MP0005167_abnormal_blood-brain_barrier	1.07399370
56	MP0001666_abnormal_nutrient_absorption	1.06643218
57	MP0002118_abnormal_lipid_homeostasis	1.05089439
58	MP0004885_abnormal_endolymph	1.04942728
59	MP0005386_behavior/neurological_phenoty	1.03065371
60	MP0004924_abnormal_behavior	1.03065371
61	MP0002822_catalepsy	0.97110288
62	MP0004742_abnormal_vestibular_system	0.95735593
63	MP0002557_abnormal_social/conspecific_i	0.95538454
64	MP0001501_abnormal_sleep_pattern	0.95014773
65	MP0002277_abnormal_respiratory_mucosa	0.94875407
66	MP0002272_abnormal_nervous_system	0.93995586
67	MP0005084_abnormal_gallbladder_morpholo	0.92532923
68	MP0001324_abnormal_eye_pigmentation	0.92489718
69	MP0009840_abnormal_foam_cell	0.91859853
70	MP0005670_abnormal_white_adipose	0.91781880
71	MP0001502_abnormal_circadian_rhythm	0.91541611
72	MP0003646_muscle_fatigue	0.91466433
73	MP0005187_abnormal_penis_morphology	0.90809100
74	MP0009764_decreased_sensitivity_to	0.89954855
75	MP0002733_abnormal_thermal_nociception	0.89269136
76	MP0003787_abnormal_imprinting	0.87750199
77	MP0000609_abnormal_liver_physiology	0.87594619
78	MP0003806_abnormal_nucleotide_metabolis	0.85607333
79	MP0002160_abnormal_reproductive_system	0.84147421
80	MP0000631_abnormal_neuroendocrine_gland	0.82234984
81	MP0005319_abnormal_enzyme/_coenzyme	0.82159719
82	MP0001919_abnormal_reproductive_system	0.81692597
83	MP0001929_abnormal_gametogenesis	0.80610331
84	MP0001661_extended_life_span	0.79174491
85	MP0000647_abnormal_sebaceous_gland	0.79093393
86	MP0004019_abnormal_vitamin_homeostasis	0.76133488
87	MP0000427_abnormal_hair_cycle	0.76005750
88	MP0001963_abnormal_hearing_physiology	0.74581855
89	MP0002735_abnormal_chemical_nociception	0.74200859
90	MP0009785_altered_susceptibility_to	0.74137886
91	MP0002572_abnormal_emotion/affect_behav	0.73968802
92	MP0005377_hearing/vestibular/ear_phenot	0.72484955
93	MP0003878_abnormal_ear_physiology	0.72484955
94	MP0002282_abnormal_trachea_morphology	0.70115454
95	MP0002736_abnormal_nociception_after	0.70023940
96	MP0005408_hypopigmentation	0.69945974
97	MP0005334_abnormal_fat_pad	0.69660429
98	MP0000015_abnormal_ear_pigmentation	0.68958657
99	MP0003953_abnormal_hormone_level	0.68878817
100	MP0001970_abnormal_pain_threshold	0.68029006

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	4.41776147
2	Complement deficiency (HP:0004431)	3.74309360
3	Congenital stationary night blindness (HP:0007642)	3.73509191
4	Renal salt wasting (HP:0000127)	3.67960875
5	Hypobetalipoproteinemia (HP:0003563)	3.29964141
6	Epidermoid cyst (HP:0200040)	3.16910709
7	Hyperventilation (HP:0002883)	3.16247944
8	Deep venous thrombosis (HP:0002625)	3.11074994
9	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.07703467
10	Joint hemorrhage (HP:0005261)	3.01950259
11	Decreased central vision (HP:0007663)	2.97769837
12	Abnormality of the renal cortex (HP:0011035)	2.89398321
13	Intestinal atresia (HP:0011100)	2.81467812
14	Thyroid-stimulating hormone excess (HP:0002925)	2.81351535
15	Hyperlipoproteinemia (HP:0010980)	2.77395947
16	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.76889952
17	Hyperaldosteronism (HP:0000859)	2.73110981
18	Conjugated hyperbilirubinemia (HP:0002908)	2.72472191
19	Nephronophthisis (HP:0000090)	2.68611427
20	Decreased circulating renin level (HP:0003351)	2.66310025
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.56511208
22	Pancreatic cysts (HP:0001737)	2.54983772
23	Hypokalemic alkalosis (HP:0001949)	2.49252058
24	Attenuation of retinal blood vessels (HP:0007843)	2.48523797
25	Abnormality of the renal medulla (HP:0100957)	2.48090257
26	Abnormal drinking behavior (HP:0030082)	2.46787227
27	Polydipsia (HP:0001959)	2.46787227
28	Abnormality of midbrain morphology (HP:0002418)	2.45239901
29	Molar tooth sign on MRI (HP:0002419)	2.45239901
30	Xanthomatosis (HP:0000991)	2.44446974
31	Male pseudohermaphroditism (HP:0000037)	2.37521644
32	Gaze-evoked nystagmus (HP:0000640)	2.35395602
33	Hyperglycinuria (HP:0003108)	2.34240846
34	Abnormality of complement system (HP:0005339)	2.33232278
35	True hermaphroditism (HP:0010459)	2.32276904
36	Focal motor seizures (HP:0011153)	2.31615120
37	Hypoplasia of the uterus (HP:0000013)	2.30252570
38	Ketosis (HP:0001946)	2.30202620
39	Large eyes (HP:0001090)	2.28622601
40	Abolished electroretinogram (ERG) (HP:0000550)	2.28300482
41	Tubular atrophy (HP:0000092)	2.28288730
42	Type II lissencephaly (HP:0007260)	2.27281787
43	Azoospermia (HP:0000027)	2.26135729
44	Abnormality of serine family amino acid metabolism (HP:0010894)	2.24050738
45	Abnormality of glycine metabolism (HP:0010895)	2.24050738
46	Pancreatic fibrosis (HP:0100732)	2.20795947
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.20138786
48	Large for gestational age (HP:0001520)	2.17888428
49	Progressive inability to walk (HP:0002505)	2.17430250
50	Hyperglycinemia (HP:0002154)	2.16344443
51	Aplasia/hypoplasia of the uterus (HP:0008684)	2.15574608
52	Hypothermia (HP:0002045)	2.14583857
53	Glomerulonephritis (HP:0000099)	2.14539102
54	Mesangial abnormality (HP:0001966)	2.13521824
55	Lipid accumulation in hepatocytes (HP:0006561)	2.11481315
56	Glycosuria (HP:0003076)	2.10821589
57	Abnormality of urine glucose concentration (HP:0011016)	2.10821589
58	Renal cortical cysts (HP:0000803)	2.09994687
59	Spontaneous abortion (HP:0005268)	2.09604609
60	Bony spicule pigmentary retinopathy (HP:0007737)	2.06255124
61	Polyuria (HP:0000103)	2.05569001
62	Increased corneal curvature (HP:0100692)	2.05068353
63	Keratoconus (HP:0000563)	2.05068353
64	Increased hepatocellular lipid droplets (HP:0006565)	2.03609535
65	Increased CSF lactate (HP:0002490)	2.03001333
66	Abnormal sex determination (HP:0012244)	2.02519070
67	Sex reversal (HP:0012245)	2.02519070
68	Retrobulbar optic neuritis (HP:0100654)	2.02252897
69	Optic neuritis (HP:0100653)	2.02252897
70	Abnormal urine output (HP:0012590)	2.01583994
71	Medial flaring of the eyebrow (HP:0010747)	2.00405417
72	Alkalosis (HP:0001948)	1.96158315
73	Ketoacidosis (HP:0001993)	1.95182337
74	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.93318284
75	Hypoproteinemia (HP:0003075)	1.92263724
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.91001743
77	Abnormal biliary tract physiology (HP:0012439)	1.90403756
78	Bile duct proliferation (HP:0001408)	1.90403756
79	Chronic hepatic failure (HP:0100626)	1.89864506
80	Hypolipoproteinemia (HP:0010981)	1.89561047
81	Mitochondrial inheritance (HP:0001427)	1.88095925
82	Inability to walk (HP:0002540)	1.86275444
83	Optic disc pallor (HP:0000543)	1.86245179
84	Pulmonary embolism (HP:0002204)	1.85187954
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85004257
86	Abnormality of alanine metabolism (HP:0010916)	1.85004257
87	Hyperalaninemia (HP:0003348)	1.85004257
88	Methylmalonic aciduria (HP:0012120)	1.83770613
89	Abnormality of serum amino acid levels (HP:0003112)	1.83070856
90	Orchitis (HP:0100796)	1.82488952
91	Gangrene (HP:0100758)	1.81604501
92	Acute necrotizing encephalopathy (HP:0006965)	1.80661378
93	Severe visual impairment (HP:0001141)	1.80500452
94	Fair hair (HP:0002286)	1.79318409
95	Absent/shortened dynein arms (HP:0200106)	1.78268336
96	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.78268336
97	Absent speech (HP:0001344)	1.76549905
98	Broad alveolar ridges (HP:0000187)	1.75440628
99	Bilateral microphthalmos (HP:0007633)	1.75105969
100	Systemic lupus erythematosus (HP:0002725)	1.74148185

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.20744104
2	ADRBK2	3.13496552
3	MAP4K2	2.99132743
4	TAOK3	2.89872313
5	PINK1	2.67817446
6	TXK	2.52366259
7	PNCK	2.36663720
8	MAPK15	2.35314840
9	WNK3	2.21480037
10	ZAK	2.15178019
11	NUAK1	2.14100736
12	WNK4	2.05043468
13	MAP3K4	1.67008584
14	CASK	1.58065561
15	TRIM28	1.55242403
16	VRK1	1.51794412
17	EIF2AK3	1.50795647
18	NTRK3	1.48911598
19	BMPR1B	1.48280625
20	GRK1	1.48070381
21	ACVR1B	1.47116636
22	MAP2K7	1.41054649
23	MAPK13	1.26206608
24	AKT3	1.25027597
25	MAP2K6	1.24287011
26	PIK3CA	1.24169159
27	PLK4	1.22546091
28	BCKDK	1.16168217
29	TLK1	1.14218836
30	PRKCG	1.13618812
31	ADRBK1	1.10687414
32	MAP3K12	1.09134493
33	OXSR1	1.08732972
34	PLK2	1.04205582
35	CDK8	0.99501730
36	CSF1R	0.99472022
37	MST4	0.95239746
38	PRKCE	0.93841683
39	MAP3K5	0.89421232
40	TGFBR2	0.88937696
41	TNK2	0.88682229
42	WEE1	0.88129941
43	ERBB3	0.86538823
44	KIT	0.86511886
45	GRK7	0.81171644
46	CDK3	0.81054510
47	KDR	0.80859405
48	INSRR	0.79389190
49	CSNK1G2	0.78454654
50	CSNK1G3	0.76510097
51	ITK	0.76374954
52	PDK2	0.76249395
53	CSNK1G1	0.73235834
54	EPHA3	0.72434488
55	STK39	0.72111497
56	MAP2K4	0.71803973
57	FLT3	0.70737086
58	STK38L	0.69292527
59	SIK2	0.69119755
60	ERBB2	0.67550153
61	DAPK2	0.65461872
62	CSNK1A1L	0.64497746
63	GRK5	0.64254968
64	TESK2	0.61608536
65	CAMK2A	0.59957502
66	IRAK1	0.59816570
67	NTRK2	0.59712885
68	PKN1	0.59027504
69	IGF1R	0.57660680
70	BCR	0.57610830
71	DYRK1A	0.57352791
72	PTK2B	0.55353076
73	MAP3K7	0.55287502
74	EPHA4	0.54052728
75	PRKCQ	0.53518443
76	PHKG1	0.53393379
77	PHKG2	0.53393379
78	TIE1	0.53348971
79	PRKACA	0.51795905
80	MARK1	0.51384513
81	TSSK6	0.50090584
82	EIF2AK1	0.49933257
83	IKBKB	0.48901858
84	CSNK1A1	0.48447160
85	PRKACG	0.48237880
86	PRKG1	0.47640575
87	SGK1	0.46734129
88	PLK3	0.46350864
89	PAK3	0.45521029
90	ERN1	0.43321954
91	PRKCI	0.43199655
92	CDK7	0.42912390
93	PRKAA2	0.41661270
94	DYRK2	0.41030078
95	PRKCZ	0.37978326
96	CAMK1	0.37922129
97	TYK2	0.37590888
98	MAP4K1	0.36185110
99	STK16	0.35767126
100	CSNK1D	0.35627498

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Steroid hormone biosynthesis_Homo sapiens_hsa00140	3.17119901
2	Caffeine metabolism_Homo sapiens_hsa00232	3.03912887
3	Complement and coagulation cascades_Homo sapiens_hsa04610	2.87750517
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.77570605
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.69824338
6	Butanoate metabolism_Homo sapiens_hsa00650	2.61154954
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.52644641
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.46862251
9	Retinol metabolism_Homo sapiens_hsa00830	2.39993978
10	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.36735228
11	Chemical carcinogenesis_Homo sapiens_hsa05204	2.30836657
12	Tryptophan metabolism_Homo sapiens_hsa00380	2.19922172
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14085867
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.12296464
15	Linoleic acid metabolism_Homo sapiens_hsa00591	2.11362606
16	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.07515399
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05755909
18	Fatty acid degradation_Homo sapiens_hsa00071	1.96737786
19	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.83291257
20	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.80055138
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.78647863
22	Arginine biosynthesis_Homo sapiens_hsa00220	1.77432942
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.76759814
24	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.56362465
25	Propanoate metabolism_Homo sapiens_hsa00640	1.51693891
26	Peroxisome_Homo sapiens_hsa04146	1.45581360
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.39920389
28	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.39036626
29	ABC transporters_Homo sapiens_hsa02010	1.38674915
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.38065455
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.35629900
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.33871604
33	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.32361370
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.29378056
35	Histidine metabolism_Homo sapiens_hsa00340	1.28226858
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.27927682
37	Phototransduction_Homo sapiens_hsa04744	1.25637896
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.24369852
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.20549532
40	Tyrosine metabolism_Homo sapiens_hsa00350	1.18277376
41	Phenylalanine metabolism_Homo sapiens_hsa00360	1.14793117
42	Fatty acid metabolism_Homo sapiens_hsa01212	1.13113156
43	Basal transcription factors_Homo sapiens_hsa03022	1.10672270
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.10177599
45	Bile secretion_Homo sapiens_hsa04976	1.09340627
46	Fatty acid elongation_Homo sapiens_hsa00062	1.09217168
47	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01756094
48	Protein export_Homo sapiens_hsa03060	0.99580757
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.95570017
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95137874
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.94767689
52	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.94460445
53	Homologous recombination_Homo sapiens_hsa03440	0.93630386
54	PPAR signaling pathway_Homo sapiens_hsa03320	0.91722199
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.91424082
56	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.90956312
57	Oxidative phosphorylation_Homo sapiens_hsa00190	0.87126009
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.76659903
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74791415
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.74504291
61	Metabolic pathways_Homo sapiens_hsa01100	0.74323959
62	One carbon pool by folate_Homo sapiens_hsa00670	0.73319733
63	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71877516
64	Olfactory transduction_Homo sapiens_hsa04740	0.69490257
65	Sulfur metabolism_Homo sapiens_hsa00920	0.68696569
66	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.68270794
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67625023
68	Nicotine addiction_Homo sapiens_hsa05033	0.66966609
69	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.66036397
70	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64126609
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.63967986
72	Sulfur relay system_Homo sapiens_hsa04122	0.61709957
73	Circadian rhythm_Homo sapiens_hsa04710	0.60152878
74	Parkinsons disease_Homo sapiens_hsa05012	0.52859875
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.50831248
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50101138
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.48168247
78	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.47446882
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46804113
80	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.45339294
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42938515
82	Lysine degradation_Homo sapiens_hsa00310	0.41647365
83	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.41624143
84	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40567795
85	Proteasome_Homo sapiens_hsa03050	0.39488902
86	Taste transduction_Homo sapiens_hsa04742	0.38961370
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.37705548
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35800659
89	RNA polymerase_Homo sapiens_hsa03020	0.33963454
90	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.32874016
91	Pertussis_Homo sapiens_hsa05133	0.31931261
92	Morphine addiction_Homo sapiens_hsa05032	0.29897766
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27540233
94	Serotonergic synapse_Homo sapiens_hsa04726	0.24282044
95	RNA degradation_Homo sapiens_hsa03018	0.21386472
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.20851466
97	Mineral absorption_Homo sapiens_hsa04978	0.20454127
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.20085645
99	GABAergic synapse_Homo sapiens_hsa04727	0.19716518
100	Alzheimers disease_Homo sapiens_hsa05010	0.18088323

CYP21A1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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