CYP21A1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid biosynthetic process (GO:0006704)5.18470475
2estrogen biosynthetic process (GO:0006703)5.04924358
3androgen biosynthetic process (GO:0006702)5.04485456
4exogenous drug catabolic process (GO:0042738)4.75719517
5cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.67611745
6drug catabolic process (GO:0042737)4.57800427
7benzene-containing compound metabolic process (GO:0042537)4.55379729
8indole-containing compound catabolic process (GO:0042436)4.50921690
9indolalkylamine catabolic process (GO:0046218)4.50921690
10tryptophan catabolic process (GO:0006569)4.50921690
11regulation of protein activation cascade (GO:2000257)4.35629800
12glucocorticoid metabolic process (GO:0008211)4.26926970
13aromatic amino acid family catabolic process (GO:0009074)4.19718621
14regulation of complement activation (GO:0030449)4.17525502
15complement activation, alternative pathway (GO:0006957)4.13621279
16tryptophan metabolic process (GO:0006568)4.12969155
17high-density lipoprotein particle remodeling (GO:0034375)4.07249611
18epoxygenase P450 pathway (GO:0019373)3.94059896
19indolalkylamine metabolic process (GO:0006586)3.93641262
20reverse cholesterol transport (GO:0043691)3.92279037
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.84615169
22L-phenylalanine catabolic process (GO:0006559)3.84615169
23response to follicle-stimulating hormone (GO:0032354)3.79647560
24glyoxylate metabolic process (GO:0046487)3.79593131
25C21-steroid hormone biosynthetic process (GO:0006700)3.79524912
26omega-hydroxylase P450 pathway (GO:0097267)3.74808952
27bile acid biosynthetic process (GO:0006699)3.68892206
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.65875790
29S-adenosylmethionine metabolic process (GO:0046500)3.63564561
30negative regulation of cytosolic calcium ion concentration (GO:0051481)3.60902318
31protein-lipid complex remodeling (GO:0034368)3.58197352
32macromolecular complex remodeling (GO:0034367)3.58197352
33plasma lipoprotein particle remodeling (GO:0034369)3.58197352
34progesterone metabolic process (GO:0042448)3.56666185
35hormone biosynthetic process (GO:0042446)3.50578374
36regulation of triglyceride catabolic process (GO:0010896)3.47173111
37oxidative demethylation (GO:0070989)3.43753379
38triglyceride homeostasis (GO:0070328)3.43401365
39acylglycerol homeostasis (GO:0055090)3.43401365
40serine family amino acid catabolic process (GO:0009071)3.39328583
41kynurenine metabolic process (GO:0070189)3.37471481
42mannosylation (GO:0097502)3.36505847
43bile acid metabolic process (GO:0008206)3.36035746
44cellular ketone body metabolic process (GO:0046950)3.35643193
45cellular response to gonadotropin stimulus (GO:0071371)3.33034482
46regulation of fibrinolysis (GO:0051917)3.32777450
47drug metabolic process (GO:0017144)3.25050909
48cholesterol efflux (GO:0033344)3.24992471
49piRNA metabolic process (GO:0034587)3.22723421
50aromatic amino acid family metabolic process (GO:0009072)3.22148043
51glucuronate metabolic process (GO:0019585)3.21594226
52uronic acid metabolic process (GO:0006063)3.21594226
53C21-steroid hormone metabolic process (GO:0008207)3.21576301
54cellular glucuronidation (GO:0052695)3.18373207
55intestinal cholesterol absorption (GO:0030299)3.17135054
56cellular response to cadmium ion (GO:0071276)3.17013699
57dopamine transport (GO:0015872)3.15342132
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15036351
59ketone biosynthetic process (GO:0042181)3.12201527
60ketone body metabolic process (GO:1902224)3.11319178
61negative regulation of cAMP-mediated signaling (GO:0043951)3.11153994
62cellular biogenic amine catabolic process (GO:0042402)3.08001073
63amine catabolic process (GO:0009310)3.08001073
64DNA deamination (GO:0045006)3.07864480
65cellular response to antibiotic (GO:0071236)3.05736658
66detection of light stimulus involved in sensory perception (GO:0050962)3.05488069
67detection of light stimulus involved in visual perception (GO:0050908)3.05488069
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.05342725
69L-phenylalanine metabolic process (GO:0006558)3.05342725
70negative regulation of protein activation cascade (GO:2000258)3.02443500
71androgen metabolic process (GO:0008209)2.98438106
72regulation of acrosome reaction (GO:0060046)2.98013061
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97641093
74response to insecticide (GO:0017085)2.97120697
75amino-acid betaine metabolic process (GO:0006577)2.94055707
76arginine metabolic process (GO:0006525)2.94030848
77steroid catabolic process (GO:0006706)2.93960197
78L-methionine salvage (GO:0071267)2.91351505
79L-methionine biosynthetic process (GO:0071265)2.91351505
80amino acid salvage (GO:0043102)2.91351505
81negative regulation of fibrinolysis (GO:0051918)2.89252804
82cysteine metabolic process (GO:0006534)2.87373962
83blood coagulation, intrinsic pathway (GO:0007597)2.85193856
84toxin metabolic process (GO:0009404)2.85035537
85water-soluble vitamin biosynthetic process (GO:0042364)2.84400806
86plasma lipoprotein particle organization (GO:0071827)2.83308590
87plasma lipoprotein particle clearance (GO:0034381)2.82644933
88behavioral response to nicotine (GO:0035095)2.81217215
89alpha-amino acid catabolic process (GO:1901606)2.80470593
90alkaloid metabolic process (GO:0009820)2.77620435
91cellular response to toxic substance (GO:0097237)2.76612603
92regulation of glucokinase activity (GO:0033131)2.75164913
93regulation of hexokinase activity (GO:1903299)2.75164913
94sterol transport (GO:0015918)2.75155315
95cholesterol transport (GO:0030301)2.75155315
96behavioral response to ethanol (GO:0048149)2.74702228
97drug transmembrane transport (GO:0006855)2.74566378
98cellular ketone metabolic process (GO:0042180)2.73978748
99peptidyl-glutamic acid carboxylation (GO:0017187)2.73166536
100protein carboxylation (GO:0018214)2.73166536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.61129949
2ZNF274_21170338_ChIP-Seq_K562_Hela3.34359452
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13317876
4IGF1R_20145208_ChIP-Seq_DFB_Human2.98645393
5GBX2_23144817_ChIP-Seq_PC3_Human2.77280668
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.66154861
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48609960
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.38366720
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.35710655
10TAF15_26573619_Chip-Seq_HEK293_Human2.26572973
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13225425
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08420583
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07504500
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04637297
15BCAT_22108803_ChIP-Seq_LS180_Human1.99602641
16ER_23166858_ChIP-Seq_MCF-7_Human1.93383046
17IRF1_19129219_ChIP-ChIP_H3396_Human1.92801609
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85156620
19NFE2_27457419_Chip-Seq_LIVER_Mouse1.79969564
20FUS_26573619_Chip-Seq_HEK293_Human1.78063854
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.77758513
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75811159
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72214164
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71559039
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.69497138
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65782504
27P300_19829295_ChIP-Seq_ESCs_Human1.63314911
28TCF4_22108803_ChIP-Seq_LS180_Human1.61920365
29EWS_26573619_Chip-Seq_HEK293_Human1.60975886
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59763552
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.52976892
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52793302
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.52667555
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50111359
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48992671
36CBP_20019798_ChIP-Seq_JUKART_Human1.48992671
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48430937
38TP53_22573176_ChIP-Seq_HFKS_Human1.45999075
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.44699375
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44503454
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42117083
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42004713
43TCF4_23295773_ChIP-Seq_U87_Human1.41497687
44CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37846780
45CRX_20693478_ChIP-Seq_RETINA_Mouse1.37572381
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37085566
47SOX2_19829295_ChIP-Seq_ESCs_Human1.35910710
48NANOG_19829295_ChIP-Seq_ESCs_Human1.35910710
49HTT_18923047_ChIP-ChIP_STHdh_Human1.35877428
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34534740
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33712091
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.33694837
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33650887
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33518463
55STAT3_23295773_ChIP-Seq_U87_Human1.31985946
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.30384841
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30384841
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30197882
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26377234
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25842651
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25842651
62AR_25329375_ChIP-Seq_VCAP_Human1.25296714
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24701797
64NCOR_22424771_ChIP-Seq_293T_Human1.24390984
65OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23537321
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22025977
67CDX2_22108803_ChIP-Seq_LS180_Human1.21788170
68SMAD4_21799915_ChIP-Seq_A2780_Human1.21495240
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20747527
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.18828540
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18571754
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16881934
73AR_20517297_ChIP-Seq_VCAP_Human1.15880990
74HOXB7_26014856_ChIP-Seq_BT474_Human1.15645085
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15562029
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15009439
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.14773604
78RUNX2_22187159_ChIP-Seq_PCA_Human1.14766915
79MYC_19829295_ChIP-Seq_ESCs_Human1.13859464
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13012947
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.12899642
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.12323295
83AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11591152
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08845296
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08756571
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05738074
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.04113672
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02538027
89P53_22387025_ChIP-Seq_ESCs_Mouse1.02523622
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01834843
91FOXH1_21741376_ChIP-Seq_EPCs_Human1.01610757
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.01575024
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00979584
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00491401
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.99917329
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99734577
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98253330
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98056923
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97944147
100CEBPB_22108803_ChIP-Seq_LS180_Human0.96575705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.27890488
2MP0008875_abnormal_xenobiotic_pharmacok3.89692367
3MP0002139_abnormal_hepatobiliary_system3.73468970
4MP0005360_urolithiasis3.33789599
5MP0005085_abnormal_gallbladder_physiolo2.97260662
6MP0002876_abnormal_thyroid_physiology2.89094140
7MP0005365_abnormal_bile_salt2.84544295
8MP0008877_abnormal_DNA_methylation2.61949607
9MP0003252_abnormal_bile_duct2.42742821
10MP0003136_yellow_coat_color2.40656235
11MP0002102_abnormal_ear_morphology2.15288158
12MP0000639_abnormal_adrenal_gland2.15066336
13MP0005551_abnormal_eye_electrophysiolog2.14284567
14MP0000372_irregular_coat_pigmentation2.12658543
15MP0002909_abnormal_adrenal_gland2.07746965
16MP0010329_abnormal_lipoprotein_level2.01747552
17MP0002138_abnormal_hepatobiliary_system1.99239779
18MP0000013_abnormal_adipose_tissue1.95203179
19MP0005646_abnormal_pituitary_gland1.84092585
20MP0001968_abnormal_touch/_nociception1.78665070
21MP0005645_abnormal_hypothalamus_physiol1.75805054
22MP0001764_abnormal_homeostasis1.70755651
23MP0009780_abnormal_chondrocyte_physiolo1.68746640
24MP0008995_early_reproductive_senescence1.66874904
25MP0005332_abnormal_amino_acid1.59895813
26MP0006292_abnormal_olfactory_placode1.55737823
27MP0003122_maternal_imprinting1.55701059
28MP0001986_abnormal_taste_sensitivity1.55586653
29MP0003011_delayed_dark_adaptation1.49563923
30MP0008872_abnormal_physiological_respon1.48712680
31MP0001984_abnormal_olfaction1.47743584
32MP0002638_abnormal_pupillary_reflex1.47713662
33MP0005253_abnormal_eye_physiology1.46478211
34MP0003880_abnormal_central_pattern1.43572962
35MP0004142_abnormal_muscle_tone1.43453336
36MP0002837_dystrophic_cardiac_calcinosis1.41760791
37MP0010368_abnormal_lymphatic_system1.40695981
38MP0006035_abnormal_mitochondrial_morpho1.30755933
39MP0006072_abnormal_retinal_apoptosis1.30582258
40MP0001529_abnormal_vocalization1.28649502
41MP0004043_abnormal_pH_regulation1.24297533
42MP0009697_abnormal_copulation1.22342614
43MP0006276_abnormal_autonomic_nervous1.19908066
44MP0003868_abnormal_feces_composition1.18432084
45MP0002938_white_spotting1.18057949
46MP0009046_muscle_twitch1.17411414
47MP0001485_abnormal_pinna_reflex1.16944331
48MP0001486_abnormal_startle_reflex1.14056633
49MP0003786_premature_aging1.13035052
50MP0009745_abnormal_behavioral_response1.10859910
51MP0006036_abnormal_mitochondrial_physio1.10849885
52MP0003121_genomic_imprinting1.09452993
53MP0005389_reproductive_system_phenotype1.09370668
54MP0005636_abnormal_mineral_homeostasis1.09367570
55MP0005167_abnormal_blood-brain_barrier1.07399370
56MP0001666_abnormal_nutrient_absorption1.06643218
57MP0002118_abnormal_lipid_homeostasis1.05089439
58MP0004885_abnormal_endolymph1.04942728
59MP0004924_abnormal_behavior1.03065371
60MP0005386_behavior/neurological_phenoty1.03065371
61MP0002822_catalepsy0.97110288
62MP0004742_abnormal_vestibular_system0.95735593
63MP0002557_abnormal_social/conspecific_i0.95538454
64MP0001501_abnormal_sleep_pattern0.95014773
65MP0002277_abnormal_respiratory_mucosa0.94875407
66MP0002272_abnormal_nervous_system0.93995586
67MP0005084_abnormal_gallbladder_morpholo0.92532923
68MP0001324_abnormal_eye_pigmentation0.92489718
69MP0009840_abnormal_foam_cell0.91859853
70MP0005670_abnormal_white_adipose0.91781880
71MP0001502_abnormal_circadian_rhythm0.91541611
72MP0003646_muscle_fatigue0.91466433
73MP0005187_abnormal_penis_morphology0.90809100
74MP0009764_decreased_sensitivity_to0.89954855
75MP0002733_abnormal_thermal_nociception0.89269136
76MP0003787_abnormal_imprinting0.87750199
77MP0000609_abnormal_liver_physiology0.87594619
78MP0003806_abnormal_nucleotide_metabolis0.85607333
79MP0002160_abnormal_reproductive_system0.84147421
80MP0000631_abnormal_neuroendocrine_gland0.82234984
81MP0005319_abnormal_enzyme/_coenzyme0.82159719
82MP0001919_abnormal_reproductive_system0.81692597
83MP0001929_abnormal_gametogenesis0.80610331
84MP0001661_extended_life_span0.79174491
85MP0000647_abnormal_sebaceous_gland0.79093393
86MP0004019_abnormal_vitamin_homeostasis0.76133488
87MP0000427_abnormal_hair_cycle0.76005750
88MP0001963_abnormal_hearing_physiology0.74581855
89MP0002735_abnormal_chemical_nociception0.74200859
90MP0009785_altered_susceptibility_to0.74137886
91MP0002572_abnormal_emotion/affect_behav0.73968802
92MP0003878_abnormal_ear_physiology0.72484955
93MP0005377_hearing/vestibular/ear_phenot0.72484955
94MP0002282_abnormal_trachea_morphology0.70115454
95MP0002736_abnormal_nociception_after0.70023940
96MP0005408_hypopigmentation0.69945974
97MP0005334_abnormal_fat_pad0.69660429
98MP0000015_abnormal_ear_pigmentation0.68958657
99MP0003953_abnormal_hormone_level0.68878817
100MP0001970_abnormal_pain_threshold0.68029006

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.41776147
2Complement deficiency (HP:0004431)3.74309360
3Congenital stationary night blindness (HP:0007642)3.73509191
4Renal salt wasting (HP:0000127)3.67960875
5Hypobetalipoproteinemia (HP:0003563)3.29964141
6Epidermoid cyst (HP:0200040)3.16910709
7Hyperventilation (HP:0002883)3.16247944
8Deep venous thrombosis (HP:0002625)3.11074994
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.07703467
10Joint hemorrhage (HP:0005261)3.01950259
11Decreased central vision (HP:0007663)2.97769837
12Abnormality of the renal cortex (HP:0011035)2.89398321
13Intestinal atresia (HP:0011100)2.81467812
14Thyroid-stimulating hormone excess (HP:0002925)2.81351535
15Hyperlipoproteinemia (HP:0010980)2.77395947
16Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76889952
17Hyperaldosteronism (HP:0000859)2.73110981
18Conjugated hyperbilirubinemia (HP:0002908)2.72472191
19Nephronophthisis (HP:0000090)2.68611427
20Decreased circulating renin level (HP:0003351)2.66310025
21Abnormal rod and cone electroretinograms (HP:0008323)2.56511208
22Pancreatic cysts (HP:0001737)2.54983772
23Hypokalemic alkalosis (HP:0001949)2.49252058
24Attenuation of retinal blood vessels (HP:0007843)2.48523797
25Abnormality of the renal medulla (HP:0100957)2.48090257
26Polydipsia (HP:0001959)2.46787227
27Abnormal drinking behavior (HP:0030082)2.46787227
28Molar tooth sign on MRI (HP:0002419)2.45239901
29Abnormality of midbrain morphology (HP:0002418)2.45239901
30Xanthomatosis (HP:0000991)2.44446974
31Male pseudohermaphroditism (HP:0000037)2.37521644
32Gaze-evoked nystagmus (HP:0000640)2.35395602
33Hyperglycinuria (HP:0003108)2.34240846
34Abnormality of complement system (HP:0005339)2.33232278
35True hermaphroditism (HP:0010459)2.32276904
36Focal motor seizures (HP:0011153)2.31615120
37Hypoplasia of the uterus (HP:0000013)2.30252570
38Ketosis (HP:0001946)2.30202620
39Large eyes (HP:0001090)2.28622601
40Abolished electroretinogram (ERG) (HP:0000550)2.28300482
41Tubular atrophy (HP:0000092)2.28288730
42Type II lissencephaly (HP:0007260)2.27281787
43Azoospermia (HP:0000027)2.26135729
44Abnormality of glycine metabolism (HP:0010895)2.24050738
45Abnormality of serine family amino acid metabolism (HP:0010894)2.24050738
46Pancreatic fibrosis (HP:0100732)2.20795947
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20138786
48Large for gestational age (HP:0001520)2.17888428
49Progressive inability to walk (HP:0002505)2.17430250
50Hyperglycinemia (HP:0002154)2.16344443
51Aplasia/hypoplasia of the uterus (HP:0008684)2.15574608
52Hypothermia (HP:0002045)2.14583857
53Glomerulonephritis (HP:0000099)2.14539102
54Mesangial abnormality (HP:0001966)2.13521824
55Lipid accumulation in hepatocytes (HP:0006561)2.11481315
56Abnormality of urine glucose concentration (HP:0011016)2.10821589
57Glycosuria (HP:0003076)2.10821589
58Renal cortical cysts (HP:0000803)2.09994687
59Spontaneous abortion (HP:0005268)2.09604609
60Bony spicule pigmentary retinopathy (HP:0007737)2.06255124
61Polyuria (HP:0000103)2.05569001
62Keratoconus (HP:0000563)2.05068353
63Increased corneal curvature (HP:0100692)2.05068353
64Increased hepatocellular lipid droplets (HP:0006565)2.03609535
65Increased CSF lactate (HP:0002490)2.03001333
66Abnormal sex determination (HP:0012244)2.02519070
67Sex reversal (HP:0012245)2.02519070
68Retrobulbar optic neuritis (HP:0100654)2.02252897
69Optic neuritis (HP:0100653)2.02252897
70Abnormal urine output (HP:0012590)2.01583994
71Medial flaring of the eyebrow (HP:0010747)2.00405417
72Alkalosis (HP:0001948)1.96158315
73Ketoacidosis (HP:0001993)1.95182337
74Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93318284
75Hypoproteinemia (HP:0003075)1.92263724
76Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91001743
77Bile duct proliferation (HP:0001408)1.90403756
78Abnormal biliary tract physiology (HP:0012439)1.90403756
79Chronic hepatic failure (HP:0100626)1.89864506
80Hypolipoproteinemia (HP:0010981)1.89561047
81Mitochondrial inheritance (HP:0001427)1.88095925
82Inability to walk (HP:0002540)1.86275444
83Optic disc pallor (HP:0000543)1.86245179
84Pulmonary embolism (HP:0002204)1.85187954
85Abnormality of alanine metabolism (HP:0010916)1.85004257
86Hyperalaninemia (HP:0003348)1.85004257
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85004257
88Methylmalonic aciduria (HP:0012120)1.83770613
89Abnormality of serum amino acid levels (HP:0003112)1.83070856
90Orchitis (HP:0100796)1.82488952
91Gangrene (HP:0100758)1.81604501
92Acute necrotizing encephalopathy (HP:0006965)1.80661378
93Severe visual impairment (HP:0001141)1.80500452
94Fair hair (HP:0002286)1.79318409
95Dynein arm defect of respiratory motile cilia (HP:0012255)1.78268336
96Absent/shortened dynein arms (HP:0200106)1.78268336
97Absent speech (HP:0001344)1.76549905
98Broad alveolar ridges (HP:0000187)1.75440628
99Bilateral microphthalmos (HP:0007633)1.75105969
100Systemic lupus erythematosus (HP:0002725)1.74148185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.20744104
2ADRBK23.13496552
3MAP4K22.99132743
4TAOK32.89872313
5PINK12.67817446
6TXK2.52366259
7PNCK2.36663720
8MAPK152.35314840
9WNK32.21480037
10ZAK2.15178019
11NUAK12.14100736
12WNK42.05043468
13MAP3K41.67008584
14CASK1.58065561
15TRIM281.55242403
16VRK11.51794412
17EIF2AK31.50795647
18NTRK31.48911598
19BMPR1B1.48280625
20GRK11.48070381
21ACVR1B1.47116636
22MAP2K71.41054649
23MAPK131.26206608
24AKT31.25027597
25MAP2K61.24287011
26PIK3CA1.24169159
27PLK41.22546091
28BCKDK1.16168217
29TLK11.14218836
30PRKCG1.13618812
31ADRBK11.10687414
32MAP3K121.09134493
33OXSR11.08732972
34PLK21.04205582
35CDK80.99501730
36CSF1R0.99472022
37MST40.95239746
38PRKCE0.93841683
39MAP3K50.89421232
40TGFBR20.88937696
41TNK20.88682229
42WEE10.88129941
43ERBB30.86538823
44KIT0.86511886
45GRK70.81171644
46CDK30.81054510
47KDR0.80859405
48INSRR0.79389190
49CSNK1G20.78454654
50CSNK1G30.76510097
51ITK0.76374954
52PDK20.76249395
53CSNK1G10.73235834
54EPHA30.72434488
55STK390.72111497
56MAP2K40.71803973
57FLT30.70737086
58STK38L0.69292527
59SIK20.69119755
60ERBB20.67550153
61DAPK20.65461872
62CSNK1A1L0.64497746
63GRK50.64254968
64TESK20.61608536
65CAMK2A0.59957502
66IRAK10.59816570
67NTRK20.59712885
68PKN10.59027504
69IGF1R0.57660680
70BCR0.57610830
71DYRK1A0.57352791
72PTK2B0.55353076
73MAP3K70.55287502
74EPHA40.54052728
75PRKCQ0.53518443
76PHKG20.53393379
77PHKG10.53393379
78TIE10.53348971
79PRKACA0.51795905
80MARK10.51384513
81TSSK60.50090584
82EIF2AK10.49933257
83IKBKB0.48901858
84CSNK1A10.48447160
85PRKACG0.48237880
86PRKG10.47640575
87SGK10.46734129
88PLK30.46350864
89PAK30.45521029
90ERN10.43321954
91PRKCI0.43199655
92CDK70.42912390
93PRKAA20.41661270
94DYRK20.41030078
95PRKCZ0.37978326
96CAMK10.37922129
97TYK20.37590888
98MAP4K10.36185110
99STK160.35767126
100CSNK1D0.35627498

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001403.17119901
2Caffeine metabolism_Homo sapiens_hsa002323.03912887
3Complement and coagulation cascades_Homo sapiens_hsa046102.87750517
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.77570605
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.69824338
6Butanoate metabolism_Homo sapiens_hsa006502.61154954
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.52644641
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.46862251
9Retinol metabolism_Homo sapiens_hsa008302.39993978
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36735228
11Chemical carcinogenesis_Homo sapiens_hsa052042.30836657
12Tryptophan metabolism_Homo sapiens_hsa003802.19922172
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14085867
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12296464
15Linoleic acid metabolism_Homo sapiens_hsa005912.11362606
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.07515399
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05755909
18Fatty acid degradation_Homo sapiens_hsa000711.96737786
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83291257
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80055138
21Nitrogen metabolism_Homo sapiens_hsa009101.78647863
22Arginine biosynthesis_Homo sapiens_hsa002201.77432942
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76759814
24Ovarian steroidogenesis_Homo sapiens_hsa049131.56362465
25Propanoate metabolism_Homo sapiens_hsa006401.51693891
26Peroxisome_Homo sapiens_hsa041461.45581360
27Steroid biosynthesis_Homo sapiens_hsa001001.39920389
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39036626
29ABC transporters_Homo sapiens_hsa020101.38674915
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38065455
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35629900
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33871604
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.32361370
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29378056
35Histidine metabolism_Homo sapiens_hsa003401.28226858
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27927682
37Phototransduction_Homo sapiens_hsa047441.25637896
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.24369852
39Fat digestion and absorption_Homo sapiens_hsa049751.20549532
40Tyrosine metabolism_Homo sapiens_hsa003501.18277376
41Phenylalanine metabolism_Homo sapiens_hsa003601.14793117
42Fatty acid metabolism_Homo sapiens_hsa012121.13113156
43Basal transcription factors_Homo sapiens_hsa030221.10672270
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10177599
45Bile secretion_Homo sapiens_hsa049761.09340627
46Fatty acid elongation_Homo sapiens_hsa000621.09217168
47Fanconi anemia pathway_Homo sapiens_hsa034601.01756094
48Protein export_Homo sapiens_hsa030600.99580757
49Arachidonic acid metabolism_Homo sapiens_hsa005900.95570017
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95137874
51beta-Alanine metabolism_Homo sapiens_hsa004100.94767689
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.94460445
53Homologous recombination_Homo sapiens_hsa034400.93630386
54PPAR signaling pathway_Homo sapiens_hsa033200.91722199
55Ether lipid metabolism_Homo sapiens_hsa005650.91424082
56Staphylococcus aureus infection_Homo sapiens_hsa051500.90956312
57Oxidative phosphorylation_Homo sapiens_hsa001900.87126009
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76659903
59Glycerolipid metabolism_Homo sapiens_hsa005610.74791415
60Selenocompound metabolism_Homo sapiens_hsa004500.74504291
61Metabolic pathways_Homo sapiens_hsa011000.74323959
62One carbon pool by folate_Homo sapiens_hsa006700.73319733
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71877516
64Olfactory transduction_Homo sapiens_hsa047400.69490257
65Sulfur metabolism_Homo sapiens_hsa009200.68696569
66Starch and sucrose metabolism_Homo sapiens_hsa005000.68270794
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.67625023
68Nicotine addiction_Homo sapiens_hsa050330.66966609
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66036397
70Arginine and proline metabolism_Homo sapiens_hsa003300.64126609
71Primary immunodeficiency_Homo sapiens_hsa053400.63967986
72Sulfur relay system_Homo sapiens_hsa041220.61709957
73Circadian rhythm_Homo sapiens_hsa047100.60152878
74Parkinsons disease_Homo sapiens_hsa050120.52859875
75Non-homologous end-joining_Homo sapiens_hsa034500.50831248
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50101138
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48168247
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.47446882
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.46804113
80Vitamin B6 metabolism_Homo sapiens_hsa007500.45339294
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42938515
82Lysine degradation_Homo sapiens_hsa003100.41647365
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.41624143
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40567795
85Proteasome_Homo sapiens_hsa030500.39488902
86Taste transduction_Homo sapiens_hsa047420.38961370
87Pyruvate metabolism_Homo sapiens_hsa006200.37705548
88Fatty acid biosynthesis_Homo sapiens_hsa000610.35800659
89RNA polymerase_Homo sapiens_hsa030200.33963454
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32874016
91Pertussis_Homo sapiens_hsa051330.31931261
92Morphine addiction_Homo sapiens_hsa050320.29897766
93Vitamin digestion and absorption_Homo sapiens_hsa049770.27540233
94Serotonergic synapse_Homo sapiens_hsa047260.24282044
95RNA degradation_Homo sapiens_hsa030180.21386472
96Nucleotide excision repair_Homo sapiens_hsa034200.20851466
97Mineral absorption_Homo sapiens_hsa049780.20454127
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20085645
99GABAergic synapse_Homo sapiens_hsa047270.19716518
100Alzheimers disease_Homo sapiens_hsa050100.18088323

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