ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to gonadotropin stimulus (GO:0071371)	9.76400432
2	cellular response to toxic substance (GO:0097237)	8.87797718
3	Leydig cell differentiation (GO:0033327)	8.22556031
4	positive regulation of hormone biosynthetic process (GO:0046886)	7.78720045
5	benzene-containing compound metabolic process (GO:0042537)	7.44910356
6	cellular response to cadmium ion (GO:0071276)	7.17674789
7	* hormone biosynthetic process (GO:0042446)	7.15989542
8	cellular response to epinephrine stimulus (GO:0071872)	6.91316081
9	ketone biosynthetic process (GO:0042181)	6.83367224
10	response to gonadotropin (GO:0034698)	6.79758678
11	response to methylmercury (GO:0051597)	6.75862496
12	androgen metabolic process (GO:0008209)	6.70548292
13	response to corticosterone (GO:0051412)	6.20964710
14	cellular response to interferon-alpha (GO:0035457)	6.16127235
15	cellular response to growth hormone stimulus (GO:0071378)	6.04589086
16	mating behavior (GO:0007617)	5.91065863
17	positive regulation of hormone metabolic process (GO:0032352)	5.84449738
18	toxin metabolic process (GO:0009404)	5.81366881
19	response to epinephrine (GO:0071871)	5.81107651
20	positive regulation of steroid biosynthetic process (GO:0010893)	5.21420780
21	response to mineralocorticoid (GO:0051385)	5.07533030
22	pattern specification involved in kidney development (GO:0061004)	5.04634951
23	estrogen metabolic process (GO:0008210)	5.01398729
24	response to phenylpropanoid (GO:0080184)	4.92668263
25	low-density lipoprotein particle clearance (GO:0034383)	4.85958759
26	positive regulation of male gonad development (GO:2000020)	4.84838484
27	regulation of steroid hormone biosynthetic process (GO:0090030)	4.58556104
28	response to leptin (GO:0044321)	4.54990944
29	adrenal gland development (GO:0030325)	4.49465338
30	response to lead ion (GO:0010288)	4.42680614
31	detection of molecule of bacterial origin (GO:0032490)	4.25062325
32	cytokine metabolic process (GO:0042107)	4.16189367
33	response to vitamin E (GO:0033197)	4.13094485
34	intracellular lipid transport (GO:0032365)	4.11687199
35	ovulation (GO:0030728)	4.11575235
36	cellular ketone metabolic process (GO:0042180)	4.09413578
37	cellular response to dexamethasone stimulus (GO:0071549)	4.04338708
38	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.99038276
39	vitamin D metabolic process (GO:0042359)	3.92071227
40	positive regulation of steroid metabolic process (GO:0045940)	3.91552305
41	regulation of male gonad development (GO:2000018)	3.80834839
42	* steroid biosynthetic process (GO:0006694)	3.79495348
43	response to dexamethasone (GO:0071548)	3.76853456
44	* sterol metabolic process (GO:0016125)	3.74327227
45	regulation of female gonad development (GO:2000194)	3.68764691
46	sex differentiation (GO:0007548)	3.61331720
47	regulation of steroid biosynthetic process (GO:0050810)	3.60572897
48	regulation of apoptotic cell clearance (GO:2000425)	3.52717312
49	aggressive behavior (GO:0002118)	3.50852728
50	regulation of female receptivity (GO:0045924)	3.50044619
51	adhesion of symbiont to host (GO:0044406)	3.43064642
52	regulation of cholesterol biosynthetic process (GO:0045540)	3.42652839
53	cholesterol transport (GO:0030301)	3.42241044
54	sterol transport (GO:0015918)	3.42241044
55	response to growth hormone (GO:0060416)	3.36672170
56	response to antibiotic (GO:0046677)	3.34040554
57	cellular response to catecholamine stimulus (GO:0071870)	3.30067094
58	cellular response to monoamine stimulus (GO:0071868)	3.30067094
59	cholesterol efflux (GO:0033344)	3.29175841
60	* cellular hormone metabolic process (GO:0034754)	3.23802548
61	opsonization (GO:0008228)	3.23253528
62	complement activation, alternative pathway (GO:0006957)	3.22411319
63	maternal behavior (GO:0042711)	3.20713161
64	parturition (GO:0007567)	3.20159969
65	reverse cholesterol transport (GO:0043691)	3.13533585
66	cholesterol metabolic process (GO:0008203)	3.11987451
67	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.11700740
68	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.11700740
69	regulation of transmission of nerve impulse (GO:0051969)	3.09968077
70	regulation of complement activation (GO:0030449)	3.07211690
71	response to cadmium ion (GO:0046686)	3.05297207
72	regulation of triglyceride biosynthetic process (GO:0010866)	3.04206867
73	regulation of cholesterol homeostasis (GO:2000188)	3.04023997
74	bile acid biosynthetic process (GO:0006699)	3.01455187
75	multi-organism reproductive behavior (GO:0044705)	2.99906156
76	female mating behavior (GO:0060180)	2.99869663
77	positive regulation of nitric-oxide synthase activity (GO:0051000)	2.98728588
78	high-density lipoprotein particle remodeling (GO:0034375)	2.92962778
79	regulation of protein activation cascade (GO:2000257)	2.92598331
80	bile acid metabolic process (GO:0008206)	2.91119304
81	parental behavior (GO:0060746)	2.91103596
82	response to catecholamine (GO:0071869)	2.87391678
83	response to monoamine (GO:0071867)	2.87391678
84	positive regulation of lipid biosynthetic process (GO:0046889)	2.86464260
85	response to water (GO:0009415)	2.85164650
86	positive regulation of triglyceride metabolic process (GO:0090208)	2.84649683
87	regulation of hormone biosynthetic process (GO:0046885)	2.84295057
88	maintenance of protein location in nucleus (GO:0051457)	2.84185834
89	steroid catabolic process (GO:0006706)	2.83176906
90	* glucocorticoid biosynthetic process (GO:0006704)	17.1626953
91	C21-steroid hormone biosynthetic process (GO:0006700)	15.5075526
92	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	14.2155639
93	androgen biosynthetic process (GO:0006702)	13.9212458
94	* glucocorticoid metabolic process (GO:0008211)	13.3439367
95	progesterone metabolic process (GO:0042448)	11.9835794
96	cellular response to antibiotic (GO:0071236)	11.9333605
97	response to follicle-stimulating hormone (GO:0032354)	11.3812588
98	estrogen biosynthetic process (GO:0006703)	11.2770334
99	C21-steroid hormone metabolic process (GO:0008207)	11.0195797
100	response to insecticide (GO:0017085)	10.0901782

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	5.45243119
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.00408483
3	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.40184597
4	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.68145100
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.35478111
6	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.13369473
7	GBX2_23144817_ChIP-Seq_PC3_Human	3.12358589
8	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.10239096
9	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.90150366
10	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.71897460
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.59680607
12	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.52471376
13	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.47185287
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.36559623
15	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.22495191
16	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.15112349
17	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.01773869
18	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	2.00531238
19	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.99909456
20	CLOCK_20551151_ChIP-Seq_293T_Human	1.97995643
21	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.88219487
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.86747468
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86437311
24	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.77806018
25	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.77806018
26	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.76723567
27	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.69226327
28	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.69134818
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.61570155
30	GF1_26923725_Chip-Seq_HPCs_Mouse	1.56905613
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.56018033
32	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.53398385
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51938719
34	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.49533061
35	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48938991
36	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.47327186
37	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.38367943
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36192624
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36192624
40	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.32387634
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29448528
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.28176336
43	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.25181690
44	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.25181690
45	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.23958501
46	TCF4_22108803_ChIP-Seq_LS180_Human	1.20735798
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20418235
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19615094
49	AR_25329375_ChIP-Seq_VCAP_Human	1.14692834
50	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.14040039
51	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13199022
52	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12750327
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.12358949
54	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.11240135
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11094146
56	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09350919
57	POU5F1_16518401_ChIP-PET_MESCs_Mouse	1.08363947
58	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.07074778
59	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.06584268
60	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.06292020
61	TP53_18474530_ChIP-ChIP_U2OS_Human	1.06193250
62	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.05552345
63	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.05552345
64	GATA1_19941826_ChIP-Seq_K562_Human	1.03637099
65	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.03287613
66	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02386639
67	VDR_22108803_ChIP-Seq_LS180_Human	1.00755098
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99718072
69	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.97112444
70	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.96520565
71	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.95656807
72	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94843481
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94659348
74	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.94236141
75	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.93670000
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.93429792
77	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.91587563
78	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.91325131
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.91049946
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.90412087
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.89146833
82	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.87961832
83	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.87670659
84	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.87534939
85	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.87183385
86	P300_19829295_ChIP-Seq_ESCs_Human	0.86358905
87	GATA4_25053715_ChIP-Seq_YYC3_Human	0.84940990
88	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.84676189
89	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.84626097
90	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.82620812
91	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.81803603
92	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.81480976
93	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.81148136
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.79803741
95	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.78206210
96	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.77625676
97	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.77623183
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.77615193
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.77615193
100	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.77078387

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000639_abnormal_adrenal_gland	7.63097548
2	MP0002909_abnormal_adrenal_gland	7.02645808
3	MP0008995_early_reproductive_senescence	6.13705987
4	MP0010368_abnormal_lymphatic_system	5.34292850
5	MP0003941_abnormal_skin_development	5.04831134
6	MP0009840_abnormal_foam_cell	4.81834735
7	MP0008004_abnormal_stomach_pH	3.44298342
8	MP0008875_abnormal_xenobiotic_pharmacok	3.40650403
9	MP0001661_extended_life_span	2.64734599
10	MP0001984_abnormal_olfaction	2.64339909
11	MP0003122_maternal_imprinting	2.63546685
12	MP0002837_dystrophic_cardiac_calcinosis	2.56887468
13	MP0005083_abnormal_biliary_tract	2.49537892
14	MP0002254_reproductive_system_inflammat	2.32916583
15	MP0009780_abnormal_chondrocyte_physiolo	2.31311891
16	MP0003329_amyloid_beta_deposits	2.16861227
17	MP0003011_delayed_dark_adaptation	2.10907537
18	MP0001765_abnormal_ion_homeostasis	2.07744353
19	MP0003786_premature_aging	2.06538555
20	MP0000647_abnormal_sebaceous_gland	1.86170040
21	MP0000604_amyloidosis	1.82271149
22	MP0005379_endocrine/exocrine_gland_phen	1.78554751
23	MP0001879_abnormal_lymphatic_vessel	1.74753691
24	MP0005636_abnormal_mineral_homeostasis	1.74202912
25	MP0000631_abnormal_neuroendocrine_gland	1.68318672
26	MP0006276_abnormal_autonomic_nervous	1.55142363
27	MP0005187_abnormal_penis_morphology	1.53266270
28	MP0003121_genomic_imprinting	1.49346260
29	MP0001485_abnormal_pinna_reflex	1.40482001
30	MP0003191_abnormal_cellular_cholesterol	1.37986926
31	MP0010329_abnormal_lipoprotein_level	1.33986017
32	MP0003953_abnormal_hormone_level	1.31050131
33	MP0003879_abnormal_hair_cell	1.24825332
34	MP0003315_abnormal_perineum_morphology	1.23584824
35	MP0000230_abnormal_systemic_arterial	1.22428356
36	MP0002160_abnormal_reproductive_system	1.20880815
37	MP0005365_abnormal_bile_salt	1.16563448
38	MP0002557_abnormal_social/conspecific_i	1.13313090
39	MP0002269_muscular_atrophy	1.06769072
40	MP0003959_abnormal_lean_body	1.04702013
41	MP0004019_abnormal_vitamin_homeostasis	1.04629745
42	MP0001119_abnormal_female_reproductive	1.04093945
43	MP0003878_abnormal_ear_physiology	1.02584223
44	MP0005377_hearing/vestibular/ear_phenot	1.02584223
45	MP0006035_abnormal_mitochondrial_morpho	1.00104154
46	MP0004883_abnormal_blood_vessel	0.92469220
47	MP0003136_yellow_coat_color	0.89940096
48	MP0005248_abnormal_Harderian_gland	0.85681809
49	MP0002118_abnormal_lipid_homeostasis	0.83073724
50	MP0002938_white_spotting	0.83012423
51	MP0003690_abnormal_glial_cell	0.79194974
52	MP0004134_abnormal_chest_morphology	0.78691696
53	MP0005595_abnormal_vascular_smooth	0.74083538
54	MP0004085_abnormal_heartbeat	0.73533157
55	MP0001915_intracranial_hemorrhage	0.73208541
56	MP0003632_abnormal_nervous_system	0.69460779
57	MP0003950_abnormal_plasma_membrane	0.68598059
58	MP0005334_abnormal_fat_pad	0.68579761
59	MP0005319_abnormal_enzyme/_coenzyme	0.68088944
60	MP0005253_abnormal_eye_physiology	0.66574054
61	MP0005389_reproductive_system_phenotype	0.64816286
62	MP0000013_abnormal_adipose_tissue	0.64636561
63	MP0000609_abnormal_liver_physiology	0.60561932
64	MP0000343_altered_response_to	0.59698419
65	MP0000751_myopathy	0.59170910
66	MP0001929_abnormal_gametogenesis	0.57815842
67	MP0008007_abnormal_cellular_replicative	0.52821212
68	MP0005360_urolithiasis	0.52719847
69	MP0004484_altered_response_of	0.52051081
70	MP0004742_abnormal_vestibular_system	0.51653277
71	MP0000653_abnormal_sex_gland	0.50882819
72	MP0005058_abnormal_lysosome_morphology	0.50648912
73	MP0005332_abnormal_amino_acid	0.50538522
74	MP0009642_abnormal_blood_homeostasis	0.50467967
75	MP0005167_abnormal_blood-brain_barrier	0.49496866
76	MP0002139_abnormal_hepatobiliary_system	0.47913127
77	MP0000778_abnormal_nervous_system	0.46035304
78	MP0001324_abnormal_eye_pigmentation	0.45897917
79	MP0001666_abnormal_nutrient_absorption	0.45749787
80	MP0002210_abnormal_sex_determination	0.44946199
81	MP0003385_abnormal_body_wall	0.44501401
82	MP0008438_abnormal_cutaneous_collagen	0.44353133
83	MP0003787_abnormal_imprinting	0.43950691
84	MP0005410_abnormal_fertilization	0.42048537
85	MP0002998_abnormal_bone_remodeling	0.40452813
86	MP0005164_abnormal_response_to	0.40097466
87	MP0000249_abnormal_blood_vessel	0.39309309
88	MP0000598_abnormal_liver_morphology	0.36968183
89	MP0003699_abnormal_female_reproductive	0.36262538
90	MP0001486_abnormal_startle_reflex	0.34517520
91	MP0001145_abnormal_male_reproductive	0.34392287
92	MP0005076_abnormal_cell_differentiation	0.33431745
93	MP0002876_abnormal_thyroid_physiology	0.33340712
94	MP0005647_abnormal_sex_gland	0.32964552
95	MP0002653_abnormal_ependyma_morphology	0.30406505
96	MP0003137_abnormal_impulse_conducting	0.29590500
97	MP0005448_abnormal_energy_balance	0.28916846
98	MP0002127_abnormal_cardiovascular_syste	0.28262061
99	MP0002971_abnormal_brown_adipose	0.28088682
100	MP0002277_abnormal_respiratory_mucosa	0.27396955

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Enlarged penis (HP:0000040)	8.36581467
2	Abnormal sex determination (HP:0012244)	7.98511198
3	Sex reversal (HP:0012245)	7.98511198
4	Hypoplasia of the uterus (HP:0000013)	7.12663152
5	Hypokalemic alkalosis (HP:0001949)	6.61819501
6	Adrenal overactivity (HP:0002717)	5.81014794
7	Clitoromegaly (HP:0000057)	5.31173780
8	Complement deficiency (HP:0004431)	5.22566506
9	Aplasia/hypoplasia of the uterus (HP:0008684)	5.12405328
10	Male pseudohermaphroditism (HP:0000037)	5.03525001
11	Abnormality of renin-angiotensin system (HP:0000847)	4.99684253
12	Testicular neoplasm (HP:0010788)	4.11299447
13	Gonadal dysgenesis (HP:0000133)	4.03134363
14	Azoospermia (HP:0000027)	4.00635445
15	Abnormality of complement system (HP:0005339)	3.78906102
16	Abnormality of the clitoris (HP:0000056)	3.56833171
17	Neonatal onset (HP:0003623)	3.55431860
18	Recurrent gram-negative bacterial infections (HP:0005420)	3.50894295
19	Hypokalemia (HP:0002900)	3.46519377
20	Accelerated skeletal maturation (HP:0005616)	3.32451841
21	Alkalosis (HP:0001948)	3.28960061
22	Secondary amenorrhea (HP:0000869)	3.27330277
23	Abnormality of the axillary hair (HP:0100134)	3.06524777
24	Abnormality of secondary sexual hair (HP:0009888)	3.06524777
25	Epidermoid cyst (HP:0200040)	3.00505686
26	Choanal stenosis (HP:0000452)	2.96271998
27	Premature ovarian failure (HP:0008209)	2.91846135
28	Abnormal spermatogenesis (HP:0008669)	2.88574515
29	Xanthomatosis (HP:0000991)	2.86861996
30	Glomerulonephritis (HP:0000099)	2.83969254
31	Decreased testicular size (HP:0008734)	2.82470815
32	Mitral stenosis (HP:0001718)	2.72808444
33	Bicornuate uterus (HP:0000813)	2.61814441
34	Hyperpituitarism (HP:0010514)	2.60774547
35	Bifid tongue (HP:0010297)	2.55315717
36	Aplasia of the musculature (HP:0100854)	2.53135306
37	Absent eyebrow (HP:0002223)	2.50934075
38	Primary amenorrhea (HP:0000786)	2.48853637
39	Neurofibrillary tangles (HP:0002185)	2.46888321
40	Abnormality of potassium homeostasis (HP:0011042)	2.41624939
41	Tracheal stenosis (HP:0002777)	2.31271339
42	Systemic lupus erythematosus (HP:0002725)	2.25919215
43	Morphological abnormality of the middle ear (HP:0008609)	2.25873165
44	Ventricular fibrillation (HP:0001663)	2.24810334
45	Female pseudohermaphroditism (HP:0010458)	2.24134111
46	Congenital sensorineural hearing impairment (HP:0008527)	2.20649772
47	Mucopolysacchariduria (HP:0008155)	2.20305438
48	Urinary glycosaminoglycan excretion (HP:0003541)	2.20305438
49	Midline defect of the nose (HP:0004122)	2.18290518
50	Myelomeningocele (HP:0002475)	2.15885955
51	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.14736402
52	Sparse lateral eyebrow (HP:0005338)	2.11616215
53	Mesangial abnormality (HP:0001966)	2.04051546
54	Shawl scrotum (HP:0000049)	2.03788346
55	Abnormality of polysaccharide metabolism (HP:0011012)	2.01828569
56	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.01828569
57	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.01828569
58	Decreased circulating renin level (HP:0003351)	10.5881712
59	* Renal salt wasting (HP:0000127)	10.3668548
60	Hyperaldosteronism (HP:0000859)	10.0524163
61	Large earlobe (HP:0009748)	1.99498863
62	* Hypospadias (HP:0000047)	1.97959082
63	Congenital malformation of the right heart (HP:0011723)	1.95554403
64	Double outlet right ventricle (HP:0001719)	1.95554403
65	Scrotal hypoplasia (HP:0000046)	1.95081016
66	Bilateral microphthalmos (HP:0007633)	1.94961742
67	Hypoplastic nipples (HP:0002557)	1.90914287
68	Skin nodule (HP:0200036)	1.84599519
69	Abnormal pancreas size (HP:0012094)	1.75661394
70	Absent hair (HP:0002298)	1.73783603
71	Precocious puberty (HP:0000826)	1.73374430
72	Absent eyelashes (HP:0000561)	1.72623977
73	Cerebral inclusion bodies (HP:0100314)	1.71696656
74	* Gynecomastia (HP:0000771)	1.68599791
75	Acne (HP:0001061)	1.67678249
76	Resting tremor (HP:0002322)	1.67667256
77	Vaginal atresia (HP:0000148)	1.64048885
78	Cerebral palsy (HP:0100021)	1.63715098
79	Cupped ear (HP:0000378)	1.62151448
80	Hypercortisolism (HP:0001578)	1.56787949
81	Cutaneous finger syndactyly (HP:0010554)	1.55489317
82	Syncope (HP:0001279)	1.55029791
83	Metaphyseal dysplasia (HP:0100255)	1.54469742
84	Ectopic anus (HP:0004397)	1.54127400
85	Genital tract atresia (HP:0001827)	1.53574429
86	Nephritis (HP:0000123)	1.53485021
87	Bilateral sensorineural hearing impairment (HP:0008619)	1.52846193
88	Visceral angiomatosis (HP:0100761)	1.51062274
89	Prolonged QT interval (HP:0001657)	1.50662136
90	Patent foramen ovale (HP:0001655)	1.49675027
91	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.49237280
92	Atrioventricular block (HP:0001678)	1.48798315
93	Abnormality of the pubic bones (HP:0003172)	1.46377955
94	Vertebral clefting (HP:0008428)	1.46167436
95	Cervical subluxation (HP:0003308)	1.45017408
96	Breast hypoplasia (HP:0003187)	1.43390985
97	Primary adrenal insufficiency (HP:0008207)	1.42639778
98	Abnormality of the aortic arch (HP:0012303)	1.41479061
99	Bifid scrotum (HP:0000048)	1.41420181
100	Facial cleft (HP:0002006)	1.40289345

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.77661338
2	PIM2	3.68871402
3	BMPR1B	3.21643239
4	MAP3K5	3.17379210
5	DDR2	2.78240902
6	SIK1	2.76050912
7	MELK	2.45855755
8	CDK7	2.35063204
9	JAK1	2.12567085
10	ICK	2.12269243
11	AKT3	10.3830312
12	DYRK1B	1.92263776
13	PINK1	1.88249527
14	PIM1	1.83520104
15	PDK2	1.57067379
16	CDK6	1.51553542
17	TGFBR1	1.45673606
18	CAMK1D	1.43858003
19	AKT2	1.26773655
20	EIF2AK3	1.26026605
21	PDK1	1.10246893
22	JAK2	1.09346476
23	GRK5	1.06280967
24	EPHA4	1.04100938
25	PDPK1	1.02283515
26	CDK8	1.01832264
27	CAMK1G	1.00197767
28	FGFR4	0.99671700
29	MAPK12	0.92166511
30	PKN2	0.91283811
31	NTRK3	0.90439781
32	PRKAA2	0.90037646
33	NLK	0.81460910
34	SGK1	0.77423817
35	PDGFRB	0.73663390
36	FRK	0.73569887
37	YES1	0.72066842
38	NTRK1	0.71951122
39	BCKDK	0.71714735
40	STK39	0.71643037
41	CSNK1A1L	0.68998787
42	PRKCZ	0.61395117
43	MTOR	0.58835732
44	FGFR2	0.57118234
45	TIE1	0.57040098
46	MAP2K2	0.55918371
47	PHKG2	0.54924052
48	PHKG1	0.54924052
49	MYLK	0.54322009
50	MAPK3	0.54083871
51	DAPK3	0.53951377
52	ERBB4	0.51622705
53	TBK1	0.51535460
54	CAMK2D	0.50353940
55	MAP3K4	0.49150164
56	ACVR1B	0.49091560
57	INSRR	0.48407127
58	CSF1R	0.47898114
59	CSNK1G2	0.46482191
60	FER	0.46111307
61	PTK6	0.45896983
62	CAMK2B	0.42209053
63	CDK9	0.40736629
64	ABL2	0.39971591
65	CSNK1G1	0.39558689
66	PRKACA	0.39397610
67	CHUK	0.38995649
68	KDR	0.37777387
69	STK10	0.37619584
70	CSNK1G3	0.36276863
71	LATS2	0.35694444
72	CAMK2G	0.34060254
73	MAP2K7	0.33663464
74	NEK9	0.33547212
75	ERBB2	0.32678177
76	MAP2K4	0.30013588
77	MAP3K2	0.29980362
78	MAPK1	0.29687322
79	PRKD3	0.28625350
80	TGFBR2	0.27453057
81	MAPK7	0.26075657
82	WNK3	0.25139106
83	PRKCH	0.25133203
84	NTRK2	0.24534228
85	RPS6KA3	0.23828604
86	RET	0.23655319
87	SCYL2	0.23486103
88	MAP2K6	0.22722678
89	PRKAA1	0.20928611
90	MAP3K6	0.20539932
91	ABL1	0.20026032
92	MAPK4	0.19392048
93	AKT1	0.19046858
94	PRKD1	0.18697587
95	OXSR1	0.16860224
96	MAPK14	0.15971791
97	EPHA3	0.15946620
98	ROCK1	0.15396039
99	PDGFRA	0.15255609
100	IGF1R	0.15000275

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ovarian steroidogenesis_Homo sapiens_hsa04913	7.26925029
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	5.60282346
3	* Steroid hormone biosynthesis_Homo sapiens_hsa00140	5.58641614
4	Steroid biosynthesis_Homo sapiens_hsa00100	5.32179575
5	* Aldosterone synthesis and secretion_Homo sapiens_hsa04925	4.42088889
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.45915065
7	Bile secretion_Homo sapiens_hsa04976	2.19369320
8	Sulfur metabolism_Homo sapiens_hsa00920	2.14528029
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.12975821
10	Tryptophan metabolism_Homo sapiens_hsa00380	1.82627794
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.67236578
12	Chemical carcinogenesis_Homo sapiens_hsa05204	1.65224422
13	Prion diseases_Homo sapiens_hsa05020	1.56084923
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.54328114
15	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.50167415
16	Fatty acid degradation_Homo sapiens_hsa00071	1.36916167
17	Histidine metabolism_Homo sapiens_hsa00340	1.33297515
18	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.32335021
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.30600821
20	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.30543920
21	Fat digestion and absorption_Homo sapiens_hsa04975	1.29176326
22	Tyrosine metabolism_Homo sapiens_hsa00350	1.25648726
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.23174731
24	Retinol metabolism_Homo sapiens_hsa00830	1.15556561
25	Pyruvate metabolism_Homo sapiens_hsa00620	1.11995070
26	ABC transporters_Homo sapiens_hsa02010	1.04603709
27	Prolactin signaling pathway_Homo sapiens_hsa04917	1.04369108
28	beta-Alanine metabolism_Homo sapiens_hsa00410	1.03409283
29	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.00949258
30	Propanoate metabolism_Homo sapiens_hsa00640	0.99244093
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98913629
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.94482755
33	Sulfur relay system_Homo sapiens_hsa04122	0.92132299
34	Fatty acid metabolism_Homo sapiens_hsa01212	0.79065891
35	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76960629
36	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.74020854
37	Circadian rhythm_Homo sapiens_hsa04710	0.71898119
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.69034092
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.62119647
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57069394
41	ECM-receptor interaction_Homo sapiens_hsa04512	0.56012756
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54708899
43	Lysine degradation_Homo sapiens_hsa00310	0.50980023
44	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.50010735
45	Butanoate metabolism_Homo sapiens_hsa00650	0.49756771
46	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.45014204
47	Pertussis_Homo sapiens_hsa05133	0.44386909
48	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43529826
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42256190
50	Peroxisome_Homo sapiens_hsa04146	0.42237594
51	PPAR signaling pathway_Homo sapiens_hsa03320	0.41741011
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40629382
53	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.39218301
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.37539598
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37505733
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.33288171
57	Lysosome_Homo sapiens_hsa04142	0.32885686
58	Fatty acid elongation_Homo sapiens_hsa00062	0.32469012
59	Renin-angiotensin system_Homo sapiens_hsa04614	0.32457108
60	* Metabolic pathways_Homo sapiens_hsa01100	0.31338697
61	Vibrio cholerae infection_Homo sapiens_hsa05110	0.29975052
62	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.29757683
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.29334513
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.28361891
65	Arginine biosynthesis_Homo sapiens_hsa00220	0.27979182
66	Caffeine metabolism_Homo sapiens_hsa00232	0.27041872
67	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.27004796
68	Hepatitis C_Homo sapiens_hsa05160	0.25707842
69	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.24997152
70	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.24165248
71	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.22800443
72	Glutathione metabolism_Homo sapiens_hsa00480	0.22550027
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.22355569
74	Other glycan degradation_Homo sapiens_hsa00511	0.22107158
75	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.20376368
76	Melanoma_Homo sapiens_hsa05218	0.20162951
77	Linoleic acid metabolism_Homo sapiens_hsa00591	0.19724677
78	Carbon metabolism_Homo sapiens_hsa01200	0.19636959
79	GnRH signaling pathway_Homo sapiens_hsa04912	0.18655602
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.16399223
81	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.16219727
82	Focal adhesion_Homo sapiens_hsa04510	0.14835116
83	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.14742554
84	Mineral absorption_Homo sapiens_hsa04978	0.12450294
85	FoxO signaling pathway_Homo sapiens_hsa04068	0.12382186
86	Phenylalanine metabolism_Homo sapiens_hsa00360	0.11435720
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.10401945
88	Ras signaling pathway_Homo sapiens_hsa04014	0.06800846
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.06470153
90	AMPK signaling pathway_Homo sapiens_hsa04152	0.06094019
91	Prostate cancer_Homo sapiens_hsa05215	0.05273687
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.04943901
93	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.04441545
94	Choline metabolism in cancer_Homo sapiens_hsa05231	0.04259368
95	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.03999965
96	Insulin resistance_Homo sapiens_hsa04931	0.02958470
97	Protein digestion and absorption_Homo sapiens_hsa04974	0.02374902
98	Ether lipid metabolism_Homo sapiens_hsa00565	0.01455808
99	Gastric acid secretion_Homo sapiens_hsa04971	0.01151993
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.00975470

CYP21A2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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