CYP26B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1enteric nervous system development (GO:0048484)9.93111564
2positive regulation of cell size (GO:0045793)8.77604989
3regulation of glomerulus development (GO:0090192)7.35029265
4neuron cell-cell adhesion (GO:0007158)7.03777235
5positive regulation of metanephros development (GO:0072216)6.66230072
6regulation of cell maturation (GO:1903429)6.65420851
7innervation (GO:0060384)6.26799688
8sympathetic nervous system development (GO:0048485)5.25242563
9neuron maturation (GO:0042551)5.25143144
10endocardial cushion morphogenesis (GO:0003203)5.11291153
11positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)5.03849496
12gonadal mesoderm development (GO:0007506)4.90620487
13planar cell polarity pathway involved in neural tube closure (GO:0090179)4.70946283
14anatomical structure maturation (GO:0071695)4.66427041
15bone trabecula formation (GO:0060346)4.43604466
16mesenchyme morphogenesis (GO:0072132)4.43245110
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.37627800
18lateral sprouting from an epithelium (GO:0060601)4.29308032
19peripheral nervous system neuron development (GO:0048935)4.22864433
20cell migration in hindbrain (GO:0021535)4.22444242
21G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.21784200
22response to pain (GO:0048265)4.21280534
23positive regulation of male gonad development (GO:2000020)4.17897031
24atrioventricular valve morphogenesis (GO:0003181)4.14762631
25anatomical structure regression (GO:0060033)4.12028626
26regulation of metanephros development (GO:0072215)4.06113033
27heart valve morphogenesis (GO:0003179)3.98523941
28positive regulation of cell adhesion mediated by integrin (GO:0033630)3.97420629
29outer ear morphogenesis (GO:0042473)3.86739116
30sequestering of extracellular ligand from receptor (GO:0035581)3.84567715
31glomerular basement membrane development (GO:0032836)3.79657327
32regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.79390387
33neural crest cell migration (GO:0001755)3.79348204
34hemidesmosome assembly (GO:0031581)3.78456410
35regulation of male gonad development (GO:2000018)3.78064911
36regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.70563234
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.69317085
38coronary vasculature morphogenesis (GO:0060977)3.66953981
39bundle of His cell to Purkinje myocyte communication (GO:0086069)3.65235870
40regulation of somitogenesis (GO:0014807)3.63112725
41desmosome organization (GO:0002934)3.60000642
42dendritic spine morphogenesis (GO:0060997)3.54213161
43cell surface receptor signaling pathway involved in heart development (GO:0061311)3.53078407
44Notch signaling involved in heart development (GO:0061314)3.51810233
45mesenchymal-epithelial cell signaling (GO:0060638)3.50874043
46protein heterotrimerization (GO:0070208)3.44731456
47dopaminergic neuron differentiation (GO:0071542)3.42301769
48collagen fibril organization (GO:0030199)3.42139236
49atrial cardiac muscle cell action potential (GO:0086014)3.41380654
50non-canonical Wnt signaling pathway (GO:0035567)3.37276072
51negative regulation of catenin import into nucleus (GO:0035414)3.36558439
52hair cell differentiation (GO:0035315)3.35226048
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35208514
54auditory behavior (GO:0031223)3.31170851
55cell communication by electrical coupling (GO:0010644)3.29844029
56Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.29556487
57cranial nerve morphogenesis (GO:0021602)3.28073386
58skin morphogenesis (GO:0043589)3.27516488
59norepinephrine metabolic process (GO:0042415)3.24300659
60epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.24137890
61negative regulation of chondrocyte differentiation (GO:0032331)3.20912024
62sex determination (GO:0007530)3.20905384
63synaptic vesicle maturation (GO:0016188)3.19692934
64chondrocyte proliferation (GO:0035988)3.19632896
65neuron projection extension involved in neuron projection guidance (GO:1902284)3.18456114
66axon extension involved in axon guidance (GO:0048846)3.18456114
67negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.17551204
68aorta morphogenesis (GO:0035909)3.16974057
69regulation of establishment of planar polarity (GO:0090175)3.15423054
70behavioral response to nicotine (GO:0035095)3.14445228
71negative regulation of dendrite morphogenesis (GO:0050774)3.14210957
72cartilage morphogenesis (GO:0060536)3.11358333
73regulation of respiratory gaseous exchange (GO:0043576)3.10848928
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.10551466
75mesenchymal cell proliferation (GO:0010463)3.09935159
76type B pancreatic cell proliferation (GO:0044342)3.09795021
77germ cell migration (GO:0008354)3.07966348
78cardiac epithelial to mesenchymal transition (GO:0060317)3.07959462
79hippo signaling (GO:0035329)3.06519647
80regulation of cardioblast differentiation (GO:0051890)3.05325547
81gap junction assembly (GO:0016264)3.04343425
82cell differentiation in hindbrain (GO:0021533)3.02819931
83regulation of heart morphogenesis (GO:2000826)3.02135447
84dorsal/ventral axis specification (GO:0009950)3.00954020
85metanephros development (GO:0001656)3.00875815
86ureteric bud development (GO:0001657)3.00757888
87embryonic forelimb morphogenesis (GO:0035115)3.00706589
88heart valve formation (GO:0003188)3.00195172
89cerebellar Purkinje cell differentiation (GO:0021702)2.99034470
90regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98301616
91cell proliferation involved in kidney development (GO:0072111)2.98235328
92central nervous system projection neuron axonogenesis (GO:0021952)2.96562409
93craniofacial suture morphogenesis (GO:0097094)2.94957587
94sodium ion export (GO:0071436)2.94534067
95midgut development (GO:0007494)2.94344016
96mesonephric epithelium development (GO:0072163)2.93269273
97cerebellar granule cell differentiation (GO:0021707)2.92822151
98mesonephric tubule development (GO:0072164)2.92131531
99chondrocyte development (GO:0002063)2.91073901
100cardiac muscle cell proliferation (GO:0060038)2.90204693
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89048645
102cellular potassium ion homeostasis (GO:0030007)2.88987627
103prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.88407311
104suckling behavior (GO:0001967)2.87629980
105protein localization to cell surface (GO:0034394)2.87512154
106collagen metabolic process (GO:0032963)2.87177730
107negative regulation of cell fate specification (GO:0009996)2.87063953
108embryonic epithelial tube formation (GO:0001838)2.86102278
109glutamate secretion (GO:0014047)2.84973673
110positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.84842753
111positive regulation of cartilage development (GO:0061036)2.84005562
112middle ear morphogenesis (GO:0042474)2.82369056
113head development (GO:0060322)2.81927881
114basement membrane organization (GO:0071711)2.76774545
115negative regulation of cartilage development (GO:0061037)2.76704763
116layer formation in cerebral cortex (GO:0021819)2.75986044
117oocyte development (GO:0048599)2.75587062
118* retinoic acid metabolic process (GO:0042573)2.75214756
119multicellular organismal macromolecule metabolic process (GO:0044259)2.74583465
120cell communication involved in cardiac conduction (GO:0086065)2.74310017
121cardiac ventricle formation (GO:0003211)2.73854876
122collagen catabolic process (GO:0030574)2.73551895
123mesenchymal cell development (GO:0014031)2.73062358
124dendritic spine organization (GO:0097061)2.71932861
125epithelial tube formation (GO:0072175)2.71103093
126dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.69858968
127regulation of cardioblast proliferation (GO:0003264)2.69515295
128regulation of secondary heart field cardioblast proliferation (GO:0003266)2.69515295
129regulation of axon extension involved in axon guidance (GO:0048841)2.68891562
130cochlea morphogenesis (GO:0090103)2.68036074
131positive regulation of fatty acid beta-oxidation (GO:0032000)2.67442792
132cell proliferation involved in metanephros development (GO:0072203)2.66872095
133branching involved in salivary gland morphogenesis (GO:0060445)2.66764479
134regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.66599118
135cytoskeletal anchoring at plasma membrane (GO:0007016)2.66251417
136forelimb morphogenesis (GO:0035136)2.65524778
137regulation of cell size (GO:0008361)2.64353047
138polarized epithelial cell differentiation (GO:0030859)2.64300355
139hindlimb morphogenesis (GO:0035137)2.64266993
140gastrulation with mouth forming second (GO:0001702)2.63334576
141negative regulation of axon extension involved in axon guidance (GO:0048843)2.62637107
142behavioral response to ethanol (GO:0048149)2.62362969
143positive regulation of mesenchymal cell proliferation (GO:0002053)2.61832912
144male sex determination (GO:0030238)2.60715221
145positive regulation of epithelial to mesenchymal transition (GO:0010718)2.60677129
146regulation of catenin import into nucleus (GO:0035412)2.60542094
147trabecula formation (GO:0060343)2.60212754
148metanephric mesenchyme development (GO:0072075)2.60005426
149mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.59933710
150neural crest cell development (GO:0014032)2.59574012
151response to auditory stimulus (GO:0010996)2.59407041
152regulation of cartilage development (GO:0061035)2.58201448
153regulation of axon guidance (GO:1902667)2.58144276
154tongue development (GO:0043586)2.57925274
155artery morphogenesis (GO:0048844)2.57908290
156genitalia morphogenesis (GO:0035112)2.57738161
157auditory receptor cell differentiation (GO:0042491)2.57608208
158central nervous system neuron axonogenesis (GO:0021955)2.57596964
159cardiac right ventricle morphogenesis (GO:0003215)2.57176342
160epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55836038
161nephron tubule formation (GO:0072079)2.55576947
162multicellular organismal metabolic process (GO:0044236)2.55257260
163embryonic cranial skeleton morphogenesis (GO:0048701)2.54961227
164regulation of synaptic vesicle exocytosis (GO:2000300)2.54852157
165axonal fasciculation (GO:0007413)2.54735782
166cell migration involved in heart development (GO:0060973)2.54543580
167regulation of chondrocyte differentiation (GO:0032330)2.54481658
168lung-associated mesenchyme development (GO:0060484)2.53971984
169paraxial mesoderm development (GO:0048339)2.53103972
170embryonic skeletal joint morphogenesis (GO:0060272)2.52886082
171somatic stem cell division (GO:0048103)2.52294871
172positive regulation of kidney development (GO:0090184)2.51932463
173vocalization behavior (GO:0071625)2.49882590
174myelination in peripheral nervous system (GO:0022011)2.49832363
175peripheral nervous system axon ensheathment (GO:0032292)2.49832363
176cardiac chamber formation (GO:0003207)2.49806673
177positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.47452457
178calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44716743
179cAMP biosynthetic process (GO:0006171)2.44411290
180neuromuscular synaptic transmission (GO:0007274)2.42766118
181positive regulation of dendritic spine development (GO:0060999)2.42607696
182regulation of glutamate receptor signaling pathway (GO:1900449)2.41414139
183multicellular organismal response to stress (GO:0033555)2.40824230
184positive regulation of transcription regulatory region DNA binding (GO:2000679)2.40798029
185locomotory exploration behavior (GO:0035641)2.38108402
186postsynaptic membrane organization (GO:0001941)2.37431759
187positive regulation of glomerulus development (GO:0090193)10.6340480

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.71247744
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.58090163
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52616083
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23568711
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23568711
6WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.14897299
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.08920803
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98749569
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94570041
10* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91853147
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90725505
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89960023
13NR3C1_23031785_ChIP-Seq_PC12_Mouse1.86423704
14ESR1_21235772_ChIP-Seq_MCF-7_Human1.86265629
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84342465
16* RNF2_27304074_Chip-Seq_ESCs_Mouse1.82051442
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.79113597
18* EZH2_27304074_Chip-Seq_ESCs_Mouse1.78954361
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78826439
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74373410
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73829402
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71688289
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71607915
24* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70371136
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63104295
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62823714
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62823714
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62823714
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62668881
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61958698
31GBX2_23144817_ChIP-Seq_PC3_Human1.61733717
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61139858
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.59404177
34* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59221835
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.57268481
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53244053
37* EZH2_27294783_Chip-Seq_ESCs_Mouse1.50822922
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.50197094
39* REST_21632747_ChIP-Seq_MESCs_Mouse1.49189587
40CLOCK_20551151_ChIP-Seq_293T_Human1.48723898
41* ERG_21242973_ChIP-ChIP_JURKAT_Human1.47978486
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.47511228
43* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46455659
44AR_21572438_ChIP-Seq_LNCaP_Human1.46018335
45WT1_25993318_ChIP-Seq_PODOCYTE_Human1.45650403
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.44987774
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44749951
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44307150
49* KDM2B_26808549_Chip-Seq_K562_Human1.44087099
50* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41749380
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.39440697
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39378970
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37221741
54DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37210981
55* RING1B_27294783_Chip-Seq_NPCs_Mouse1.33451556
56* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33301735
57AHR_22903824_ChIP-Seq_MCF-7_Human1.33183604
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31327586
59ZNF263_19887448_ChIP-Seq_K562_Human1.30555353
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30257568
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.27289885
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26480008
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25038548
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24872016
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24100689
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23457839
67DROSHA_22980978_ChIP-Seq_HELA_Human1.23343744
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22077850
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.21918138
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21302424
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20741821
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20086327
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16532209
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16007305
75CTCF_27219007_Chip-Seq_Bcells_Human1.15300955
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13276869
77CJUN_26792858_Chip-Seq_BT549_Human1.12952537
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.12487177
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12145710
80TP53_16413492_ChIP-PET_HCT116_Human1.12106717
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11648897
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10324718
83EZH2_22144423_ChIP-Seq_EOC_Human1.10145017
84* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08700407
85* KDM2B_26808549_Chip-Seq_JURKAT_Human1.06158271
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05980444
87FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05918801
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.04943125
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03162274
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.02844666
91* KDM2B_26808549_Chip-Seq_DND41_Human1.02841308
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02534657
93* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02507742
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00447991
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00316279
96* RNF2_27304074_Chip-Seq_NSC_Mouse1.00243408
97* TP53_18474530_ChIP-ChIP_U2OS_Human1.00188038
98* CBX2_27304074_Chip-Seq_ESCs_Mouse0.99764271
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99197384
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98584495
101* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98232767
102P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96876268
103TBX20_22328084_ChIP-Seq_HEART_Mouse0.96840536
104TBX20_22080862_ChIP-Seq_HEART_Mouse0.96840536
105HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95884563
106NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95186499
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94824960
108CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93822709
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.93564933
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93181181
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93181181
112PIAS1_25552417_ChIP-Seq_VCAP_Human0.92836696
113* LXR_22292898_ChIP-Seq_THP-1_Human0.92184554
114* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91425146
115* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91371989
116* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91371989
117* TP53_23651856_ChIP-Seq_MEFs_Mouse0.91102708
118* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90694359
119BCAT_22108803_ChIP-Seq_LS180_Human0.89921385
120* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89049430
121TET1_21490601_ChIP-Seq_MESCs_Mouse0.88675228
122KLF5_25053715_ChIP-Seq_YYC3_Human0.87601464
123* RACK7_27058665_Chip-Seq_MCF-7_Human0.87578573
124* AR_19668381_ChIP-Seq_PC3_Human0.86787416
125RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85052345
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82239550
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80965800
128SMAD4_21799915_ChIP-Seq_A2780_Human0.80010278
129* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78441759
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78059839
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75239687
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.74248979
133MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.74100926
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.74010285
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73615732
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.73357154
137* SOX2_21211035_ChIP-Seq_LN229_Gbm0.73300428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.64387565
2MP0002822_catalepsy4.28526424
3MP0005275_abnormal_skin_tensile4.27076171
4MP0003868_abnormal_feces_composition3.77651507
5MP0003878_abnormal_ear_physiology3.44992606
6MP0005377_hearing/vestibular/ear_phenot3.44992606
7MP0002751_abnormal_autonomic_nervous3.37763788
8MP0008438_abnormal_cutaneous_collagen3.37589027
9MP0000538_abnormal_urinary_bladder3.33141431
10MP0002638_abnormal_pupillary_reflex2.97787962
11MP0004272_abnormal_basement_membrane2.94816147
12MP0005503_abnormal_tendon_morphology2.83085638
13MP0003705_abnormal_hypodermis_morpholog2.73560675
14MP0004859_abnormal_synaptic_plasticity2.60915355
15MP0005171_absent_coat_pigmentation2.48077388
16MP0003941_abnormal_skin_development2.44968983
17MP0000579_abnormal_nail_morphology2.39880959
18MP0005409_darkened_coat_color2.31282909
19MP0002796_impaired_skin_barrier2.27572688
20MP0005623_abnormal_meninges_morphology2.20508997
21MP0010030_abnormal_orbit_morphology2.18662052
22MP0009053_abnormal_anal_canal2.16301416
23MP0002249_abnormal_larynx_morphology2.11884426
24MP0000537_abnormal_urethra_morphology2.11463746
25MP0005187_abnormal_penis_morphology2.11123607
26MP0010678_abnormal_skin_adnexa2.10165943
27MP0009250_abnormal_appendicular_skeleto2.04983466
28MP0004270_analgesia2.01856417
29MP0001270_distended_abdomen2.00690993
30MP0003879_abnormal_hair_cell2.00553284
31MP0000681_abnormal_thyroid_gland1.98294661
32MP0000613_abnormal_salivary_gland1.97073907
33MP0000566_synostosis1.94494790
34MP0005423_abnormal_somatic_nervous1.93176046
35MP0009384_cardiac_valve_regurgitation1.92646731
36MP0001958_emphysema1.90334085
37MP0003635_abnormal_synaptic_transmissio1.89382774
38MP0003942_abnormal_urinary_system1.88810398
39MP0005248_abnormal_Harderian_gland1.87231983
40MP0002282_abnormal_trachea_morphology1.84077702
41MP0002184_abnormal_innervation1.81382093
42MP0010368_abnormal_lymphatic_system1.80161424
43MP0005508_abnormal_skeleton_morphology1.77777701
44MP0010386_abnormal_urinary_bladder1.76512644
45MP0003385_abnormal_body_wall1.75977049
46MP0000762_abnormal_tongue_morphology1.68362989
47MP0009780_abnormal_chondrocyte_physiolo1.67344471
48MP0000049_abnormal_middle_ear1.66929461
49MP0006054_spinal_hemorrhage1.59713920
50MP0003115_abnormal_respiratory_system1.59592881
51MP0000534_abnormal_ureter_morphology1.58242707
52MP0003880_abnormal_central_pattern1.57050826
53MP0000778_abnormal_nervous_system1.56670895
54MP0002098_abnormal_vibrissa_morphology1.55763014
55MP0002932_abnormal_joint_morphology1.55329257
56MP0004134_abnormal_chest_morphology1.52966674
57MP0003755_abnormal_palate_morphology1.51767619
58MP0002734_abnormal_mechanical_nocicepti1.51613455
59MP0000383_abnormal_hair_follicle1.47745052
60MP0002060_abnormal_skin_morphology1.47393622
61MP0001664_abnormal_digestion1.44633017
62MP0003011_delayed_dark_adaptation1.41367404
63MP0000955_abnormal_spinal_cord1.40858611
64MP0002108_abnormal_muscle_morphology1.39907146
65MP0003935_abnormal_craniofacial_develop1.37515041
66MP0002063_abnormal_learning/memory/cond1.34954384
67* MP0000428_abnormal_craniofacial_morphol1.34238561
68MP0003937_abnormal_limbs/digits/tail_de1.32105606
69MP0002938_white_spotting1.30167412
70MP0009379_abnormal_foot_pigmentation1.27627128
71MP0000639_abnormal_adrenal_gland1.27564444
72MP0001849_ear_inflammation1.26814988
73MP0003329_amyloid_beta_deposits1.25978486
74MP0003279_aneurysm1.24386492
75MP0001299_abnormal_eye_distance/1.23723076
76MP0005076_abnormal_cell_differentiation1.23370616
77MP0000647_abnormal_sebaceous_gland1.23190183
78MP0002896_abnormal_bone_mineralization1.18515820
79MP0001346_abnormal_lacrimal_gland1.18322567
80MP0005501_abnormal_skin_physiology1.17998977
81MP0009745_abnormal_behavioral_response1.17924056
82MP0004811_abnormal_neuron_physiology1.17418464
83MP0003566_abnormal_cell_adhesion1.16940446
84MP0000751_myopathy1.15018577
85MP0000377_abnormal_hair_follicle1.13639508
86MP0001485_abnormal_pinna_reflex1.13209493
87* MP0002115_abnormal_skeleton_extremities1.12839133
88MP0008569_lethality_at_weaning1.12382669
89MP0000467_abnormal_esophagus_morphology1.11409005
90MP0000767_abnormal_smooth_muscle1.08790682
91* MP0000163_abnormal_cartilage_morphology1.08238465
92MP0002233_abnormal_nose_morphology1.07692677
93MP0000013_abnormal_adipose_tissue1.07113002
94* MP0002116_abnormal_craniofacial_bone1.06837682
95MP0002064_seizures1.05907824
96MP0002572_abnormal_emotion/affect_behav1.05277475
97MP0000733_abnormal_muscle_development1.05094176
98MP0002089_abnormal_postnatal_growth/wei1.04365515
99MP0001486_abnormal_startle_reflex1.03097494
100* MP0001340_abnormal_eyelid_morphology1.02063237
101MP0006138_congestive_heart_failure1.01811842
102* MP0002109_abnormal_limb_morphology1.01028155
103MP0003122_maternal_imprinting1.00155177
104MP0002272_abnormal_nervous_system0.97982500
105MP0001177_atelectasis0.96709465
106MP0000432_abnormal_head_morphology0.94184686
107MP0003866_abnormal_defecation0.93550330
108MP0004885_abnormal_endolymph0.92854599
109MP0001216_abnormal_epidermal_layer0.88755726
110MP0003567_abnormal_fetal_cardiomyocyte0.88133587
111MP0001970_abnormal_pain_threshold0.87164648
112MP0002168_other_aberrant_phenotype0.87067784
113MP0002882_abnormal_neuron_morphology0.85864792
114MP0000026_abnormal_inner_ear0.85367218
115MP0006276_abnormal_autonomic_nervous0.85227805
116MP0000759_abnormal_skeletal_muscle0.84674077
117MP0002092_abnormal_eye_morphology0.83872310
118MP0000003_abnormal_adipose_tissue0.83447955
119MP0008995_early_reproductive_senescence0.83308989
120MP0001243_abnormal_dermal_layer0.82245876
121MP0002009_preneoplasia0.81236410
122MP0002295_abnormal_pulmonary_circulatio0.81188236
123MP0010771_integument_phenotype0.80278909
124MP0001440_abnormal_grooming_behavior0.79743975
125MP0004145_abnormal_muscle_electrophysio0.79730233
126MP0002697_abnormal_eye_size0.78741166
127MP0004858_abnormal_nervous_system0.78070991
128MP0005367_renal/urinary_system_phenotyp0.77944932
129MP0000516_abnormal_urinary_system0.77944932
130MP0002925_abnormal_cardiovascular_devel0.77739582
131MP0003119_abnormal_digestive_system0.77553532
132MP0002111_abnormal_tail_morphology0.77307505
133MP0000427_abnormal_hair_cycle0.75869854
134MP0002177_abnormal_outer_ear0.75389805
135MP0009278_abnormal_bone_marrow0.74943385
136MP0001879_abnormal_lymphatic_vessel0.73709910
137MP0003315_abnormal_perineum_morphology0.72951226
138MP0002113_abnormal_skeleton_development0.72251414
139MP0005167_abnormal_blood-brain_barrier0.71926315
140MP0001915_intracranial_hemorrhage0.71289475
141MP0002128_abnormal_blood_circulation0.70483050
142MP0003045_fibrosis0.70172105
143MP0003091_abnormal_cell_migration0.70100129
144MP0005375_adipose_tissue_phenotype0.68802646
145MP0005257_abnormal_intraocular_pressure0.68711810
146MP0001293_anophthalmia0.68603562
147MP0003861_abnormal_nervous_system0.67999131
148MP0001968_abnormal_touch/_nociception0.67054332
149MP0005666_abnormal_adipose_tissue0.66030684
150MP0002733_abnormal_thermal_nociception0.63567074
151MP0002152_abnormal_brain_morphology0.63489168
152MP0003633_abnormal_nervous_system0.62931430
153MP0002133_abnormal_respiratory_system0.62853812
154MP0005388_respiratory_system_phenotype0.62853812
155MP0002735_abnormal_chemical_nociception0.61863647
156MP0003634_abnormal_glial_cell0.60487076
157* MP0002081_perinatal_lethality0.58889555
158MP0002066_abnormal_motor_capabilities/c0.58713351
159MP0001188_hyperpigmentation0.58636029
160MP0005197_abnormal_uvea_morphology0.58505320

Predicted human phenotypes

RankGene SetZ-score
1Pheochromocytoma (HP:0002666)9.39177697
2Neuroendocrine neoplasm (HP:0100634)8.03909766
3Failure to thrive in infancy (HP:0001531)7.06433349
4Abnormality of the parathyroid morphology (HP:0011766)6.94752885
5Facial shape deformation (HP:0011334)6.79282227
6Potter facies (HP:0002009)6.79282227
7Hypercortisolism (HP:0001578)5.70645587
8Cerebral hemorrhage (HP:0001342)5.04375401
9Bicornuate uterus (HP:0000813)5.00553064
10Neoplasm of the peripheral nervous system (HP:0100007)4.96509970
11Abnormality of calcium-phosphate metabolism (HP:0100530)4.85220726
12Hyperparathyroidism (HP:0000843)4.52192515
13Protrusio acetabuli (HP:0003179)4.38005688
14Shallow orbits (HP:0000586)4.03285789
15Renal dysplasia (HP:0000110)3.94770396
16Thyroid carcinoma (HP:0002890)3.94390119
17Premature rupture of membranes (HP:0001788)3.90023460
18Short 4th metacarpal (HP:0010044)3.80118769
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.80118769
20Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.42683775
21Ankle contracture (HP:0006466)3.33496292
22Abnormality of the 4th metacarpal (HP:0010012)3.31942963
23Broad metatarsal (HP:0001783)3.25130032
24Hypercalcemia (HP:0003072)3.17378701
25Coronal craniosynostosis (HP:0004440)3.14364298
26Peripheral primitive neuroectodermal neoplasm (HP:0030067)3.13868926
27Neuroblastoma (HP:0003006)3.13868926
28Primitive neuroectodermal tumor (HP:0030065)3.13868926
29Neuroblastic tumors (HP:0004376)3.13868926
30Neonatal short-limb short stature (HP:0008921)3.07545954
31Midline defect of the nose (HP:0004122)3.02710590
32Aortic dissection (HP:0002647)3.02307376
33Atrophic scars (HP:0001075)2.97414350
34Bladder diverticulum (HP:0000015)2.95441615
35Focal motor seizures (HP:0011153)2.79122680
36Mitral valve prolapse (HP:0001634)2.76770655
37Hypoplastic ischia (HP:0003175)2.75785920
38Follicular hyperkeratosis (HP:0007502)2.72260666
39Abnormality of the parietal bone (HP:0002696)2.69667495
40Fragile skin (HP:0001030)2.68813398
41Hypothermia (HP:0002045)2.65324416
42Adrenal overactivity (HP:0002717)2.64658232
43Bell-shaped thorax (HP:0001591)2.63770270
44Type 1 muscle fiber predominance (HP:0003803)2.58901779
45Cerebral aneurysm (HP:0004944)2.58648473
46Deviation of the hallux (HP:0010051)2.53465551
47Exotropia (HP:0000577)2.50635609
48Adducted thumb (HP:0001181)2.50094651
49Aplasia involving bones of the upper limbs (HP:0009823)2.49975625
50Aplasia of the phalanges of the hand (HP:0009802)2.49975625
51Aplasia involving bones of the extremities (HP:0009825)2.49975625
52Germ cell neoplasia (HP:0100728)2.46012802
53Abnormality of the pubic bones (HP:0003172)2.45309859
54Atonic seizures (HP:0010819)2.45239226
55Vaginal atresia (HP:0000148)2.44069561
56Bronchomalacia (HP:0002780)2.42491601
57Neonatal hypoglycemia (HP:0001998)2.42323066
58Hallux valgus (HP:0001822)2.40617165
59Renal duplication (HP:0000075)2.40125392
60Soft skin (HP:0000977)2.38937225
61Abnormality of the ischium (HP:0003174)2.38115663
62Abnormality of the epiphysis of the femoral head (HP:0010574)2.34484927
63Abnormality of the middle phalanges of the toes (HP:0010183)2.34238636
64Morphological abnormality of the middle ear (HP:0008609)2.32689215
65Vitreoretinal degeneration (HP:0000655)2.32032476
66Amblyopia (HP:0000646)2.30122861
67Genital tract atresia (HP:0001827)2.30069773
68Turricephaly (HP:0000262)2.29507275
69Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.27340899
70Abnormality of femoral epiphyses (HP:0006499)2.27340899
71Renovascular hypertension (HP:0100817)2.23645493
72Wide anterior fontanel (HP:0000260)2.21333567
73Non-midline cleft lip (HP:0100335)2.20886270
74Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.20519449
75Malignant neoplasm of the central nervous system (HP:0100836)2.18977845
76Intestinal polyposis (HP:0200008)2.18626916
77Peritonitis (HP:0002586)2.18219700
78Myokymia (HP:0002411)2.17960179
79Goiter (HP:0000853)2.17845094
80Joint laxity (HP:0001388)2.16153317
81Annular pancreas (HP:0001734)2.16084348
82Increased connective tissue (HP:0009025)2.15650014
83Dilatation of the ascending aorta (HP:0005111)2.15326237
84Spinal muscular atrophy (HP:0007269)2.14226078
85Intestinal polyp (HP:0005266)2.13835500
86Neuroectodermal neoplasm (HP:0030061)2.13805143
87Neuroepithelial neoplasm (HP:0030063)2.13805143
88Nervous tissue neoplasm (HP:0030060)2.13805143
89Hip contracture (HP:0003273)2.13701130
90Increased IgE level (HP:0003212)2.11995899
91Broad toe (HP:0001837)2.11453851
92Spinal rigidity (HP:0003306)2.11067288
93Milia (HP:0001056)2.08953069
94Abnormality of the femoral head (HP:0003368)2.08795504
95Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07675241
96Increased variability in muscle fiber diameter (HP:0003557)2.05092231
97Partial duplication of the phalanx of hand (HP:0009999)2.04922317
98Abnormality of the nasolacrimal system (HP:0000614)2.04086290
99Aortic aneurysm (HP:0004942)2.03725701
100Abnormality of the diencephalon (HP:0010662)2.02796654
101Skull defect (HP:0001362)2.02037451
102Broad hallux (HP:0010055)2.01201783
103Neoplasm of the thyroid gland (HP:0100031)2.00455838
104Abnormality of the 2nd finger (HP:0004100)2.00159378
105Knee flexion contracture (HP:0006380)1.96416383
106Hyperacusis (HP:0010780)1.95977739
107Limited hip movement (HP:0008800)1.95867358
108Febrile seizures (HP:0002373)1.95250261
109Severe Myopia (HP:0011003)1.94739481
110Down-sloping shoulders (HP:0200021)1.94411748
111Exostoses (HP:0100777)1.93866279
112Elbow flexion contracture (HP:0002987)1.93648625
113Arterial tortuosity (HP:0005116)1.93537662
114Flat cornea (HP:0007720)1.93520868
115Trigonocephaly (HP:0000243)1.93307185
116Abnormal vertebral ossification (HP:0100569)1.92670404
117Orthostatic hypotension (HP:0001278)1.92320528
118Infantile muscular hypotonia (HP:0008947)1.91894989
119Hypotrichosis (HP:0001006)1.90745257
120Cutaneous finger syndactyly (HP:0010554)1.90670772
121Mildly elevated creatine phosphokinase (HP:0008180)1.89709126
122Abnormality of nail color (HP:0100643)1.89698436
123Abnormality of the lacrimal duct (HP:0011481)1.89340819
124Hypoventilation (HP:0002791)1.88878895
125Overriding aorta (HP:0002623)1.88654238
126Supernumerary ribs (HP:0005815)1.87320391
127Mixed hearing impairment (HP:0000410)1.87180616
128Vascular tortuosity (HP:0004948)1.86923182
129Sex reversal (HP:0012245)1.86176057
130Abnormal sex determination (HP:0012244)1.86176057
131Bowel diverticulosis (HP:0005222)1.85174908
132Pulmonary artery stenosis (HP:0004415)1.83706496
133Broad face (HP:0000283)1.83541894
134Preaxial foot polydactyly (HP:0001841)1.83444435
135Lymphangioma (HP:0100764)1.83264898
136Alopecia of scalp (HP:0002293)1.82979410
137Focal seizures (HP:0007359)1.82852927
138Disproportionate tall stature (HP:0001519)1.82789733
139Microglossia (HP:0000171)1.81070634
140Narrow palate (HP:0000189)1.80911439
141Thick eyebrow (HP:0000574)1.79473305
142Hypoplasia of the iris (HP:0007676)1.78814601
143Abnormality of the pulmonary veins (HP:0011718)1.78424934
144Onycholysis (HP:0001806)1.77625224
145Hyperextensible skin (HP:0000974)1.76338022
146Arnold-Chiari malformation (HP:0002308)1.76044063
147Absent eyelashes (HP:0000561)1.76028153
148Fragile nails (HP:0001808)1.74703164
149Slender build (HP:0001533)1.72506219
150Broad ribs (HP:0000885)1.72454898
151Gonadal dysgenesis (HP:0000133)1.71871327
152Abnormal autonomic nervous system physiology (HP:0012332)1.70599841
153Abnormality of skeletal muscle fiber size (HP:0012084)1.69583295
154Short phalanx of the thumb (HP:0009660)1.68352241
155Anomalous pulmonary venous return (HP:0010772)1.66081072
156Renal agenesis (HP:0000104)1.64446154
157Congenital cataract (HP:0000519)1.61016880
158Atrioventricular block (HP:0001678)1.53461872
159Obstructive sleep apnea (HP:0002870)1.51286786
160Thick nail (HP:0001805)1.49849658
161Action tremor (HP:0002345)1.49737369
162Spontaneous hematomas (HP:0007420)1.48136476
163Woolly hair (HP:0002224)1.46359910
164Abnormality of the lower motor neuron (HP:0002366)1.43934377
165Overgrowth (HP:0001548)1.43856678
166Insomnia (HP:0100785)1.43539593
167Short clavicles (HP:0000894)1.39344476
168Aplasia/Hypoplasia of the clavicles (HP:0006710)1.36970517
169Neoplasm of the heart (HP:0100544)1.36387042
170Vertebral arch anomaly (HP:0008438)1.35105916
171Laryngomalacia (HP:0001601)1.34546209
172Elfin facies (HP:0004428)1.34373628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.77334062
2LATS14.29360700
3TRIB33.35821926
4EPHB23.01701149
5RIPK12.90217502
6PNCK2.78202730
7PDGFRA2.50379025
8EPHA42.43004741
9LATS22.32351674
10TIE12.28007307
11PTK62.23471933
12CASK2.23319565
13CDK122.23236724
14SIK12.19729298
15FER2.16821122
16FGFR22.12662821
17TYRO32.00400031
18AKT31.83849278
19ICK1.80148421
20FGFR11.74242609
21SGK4941.65455179
22SGK2231.65455179
23PKN21.63122619
24DMPK1.63013770
25CAMKK11.62338469
26TTN1.62123205
27MAPK151.58633256
28EPHA31.57598785
29MAP3K101.48406232
30PRKD31.48248261
31BRD41.48142366
32SGK21.45442374
33NTRK31.44382125
34TGFBR21.44207806
35EPHB11.44160720
36BMX1.38508234
37CAMK1G1.35937455
38MAP3K61.35490919
39STK31.34753122
40ERN11.30835072
41PAK41.29113963
42CAMKK21.28294604
43CDK61.28183414
44CSNK1A1L1.26873670
45SGK31.17030272
46PTK21.16694928
47MTOR1.13635065
48TSSK61.10965852
49FGFR31.05786616
50TGFBR11.04529919
51MAP3K91.04335772
52ERBB21.04101039
53PTK2B1.03198722
54PAK21.01828866
55DAPK20.98627440
56MET0.93580828
57ERBB30.93459846
58WNK10.93044507
59PDGFRB0.93025095
60CAMK1D0.89290724
61DYRK1B0.87364409
62MAP3K70.87250982
63ROCK10.86981627
64SCYL20.86744287
65PRPF4B0.84410234
66FGFR40.84255471
67PAK30.79464936
68BCR0.79068972
69KDR0.76027315
70CDK50.73621083
71CAMK10.73263046
72MAPKAPK50.71466792
73DYRK1A0.71183620
74STK38L0.70204740
75EEF2K0.69864022
76MINK10.68465662
77MST1R0.68057381
78RET0.67857458
79CSNK1G10.65139498
80CDK90.62506872
81IGF1R0.62210122
82PRKD10.61216319
83PLK20.60979846
84PRKCH0.58053087
85UHMK10.57248812
86PRKD20.56478406
87NTRK20.56142703
88CSNK1G20.55542085
89PHKG10.53969944
90PHKG20.53969944
91PRKCG0.52520472
92ARAF0.51836865
93RPS6KA20.51126985
94LRRK20.50778007
95CSNK1G30.50632589
96ALK0.50277707
97PLK40.50228824
98NTRK10.49931011
99MAP2K40.49670151
100STK380.45092023
101CDC42BPA0.43185898
102GSK3A0.43094544
103SGK10.42208397
104CAMK40.41583999
105TESK10.41334799
106TAOK10.39754046
107PAK60.38871721
108GRK50.38763843
109MARK20.38724332
110NUAK10.38456302
111WNK40.38366873
112PRKCE0.37672430
113MAP3K40.37475813
114MAP2K70.37430324
115RPS6KC10.37347577
116RPS6KL10.37347577
117SIK20.36991902
118ILK0.36866861
119TRPM70.36329414
120ROCK20.35894533
121EGFR0.34755893
122HIPK20.34614770
123CAMK2B0.34281109
124MAPK10.33651508
125MAPK120.33455400
126KSR20.33414110
127SRC0.33049967
128LMTK20.31531217
129KSR10.31339436
130CDK150.31060152
131STK110.30911650
132MAPK70.30882074
133FLT30.30582363
134CSNK1D0.30226135
135CDK70.29860795
136MARK10.29813728
137CDK180.28084248
138CDK11A0.27828725
139MAPK100.27755826
140MAPK90.27668182
141MAP3K20.27532133
142MYLK0.27504242
143STK240.26798260
144CDK30.26726860
145RPS6KA30.26483174
146MAP2K20.25728395

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.76715835
2ECM-receptor interaction_Homo sapiens_hsa045123.43787202
3Hedgehog signaling pathway_Homo sapiens_hsa043402.66092773
4Hippo signaling pathway_Homo sapiens_hsa043902.36957955
5Protein digestion and absorption_Homo sapiens_hsa049742.26050005
6TGF-beta signaling pathway_Homo sapiens_hsa043502.25829212
7Focal adhesion_Homo sapiens_hsa045102.18062151
8Axon guidance_Homo sapiens_hsa043602.11346309
9Notch signaling pathway_Homo sapiens_hsa043302.10916170
10Nicotine addiction_Homo sapiens_hsa050332.03019036
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.02428726
12Adherens junction_Homo sapiens_hsa045202.00742521
13Proteoglycans in cancer_Homo sapiens_hsa052051.94945764
14Dorso-ventral axis formation_Homo sapiens_hsa043201.88812924
15Amoebiasis_Homo sapiens_hsa051461.84999043
16Cholinergic synapse_Homo sapiens_hsa047251.79635213
17Glutamatergic synapse_Homo sapiens_hsa047241.78127495
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.75147590
19Wnt signaling pathway_Homo sapiens_hsa043101.74017278
20Lysine degradation_Homo sapiens_hsa003101.69754214
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68260852
22Long-term potentiation_Homo sapiens_hsa047201.66121476
23Small cell lung cancer_Homo sapiens_hsa052221.64642076
24Synaptic vesicle cycle_Homo sapiens_hsa047211.63009181
25Circadian entrainment_Homo sapiens_hsa047131.61456116
26Melanogenesis_Homo sapiens_hsa049161.60570345
27GABAergic synapse_Homo sapiens_hsa047271.57160834
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55646483
29Morphine addiction_Homo sapiens_hsa050321.51712005
30Amphetamine addiction_Homo sapiens_hsa050311.46781869
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41473607
32Dopaminergic synapse_Homo sapiens_hsa047281.40650933
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36986835
34Insulin secretion_Homo sapiens_hsa049111.35914616
35MicroRNAs in cancer_Homo sapiens_hsa052061.33872531
36Salivary secretion_Homo sapiens_hsa049701.31107984
37Tight junction_Homo sapiens_hsa045301.28940301
38Pathways in cancer_Homo sapiens_hsa052001.28433120
39Dilated cardiomyopathy_Homo sapiens_hsa054141.26619258
40Melanoma_Homo sapiens_hsa052181.23534143
41PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17868735
42Rap1 signaling pathway_Homo sapiens_hsa040151.14738662
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11595070
44Prion diseases_Homo sapiens_hsa050201.11221187
45Calcium signaling pathway_Homo sapiens_hsa040201.08715572
46Chronic myeloid leukemia_Homo sapiens_hsa052201.04391803
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04279919
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01717575
49Complement and coagulation cascades_Homo sapiens_hsa046100.99675774
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97165678
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95612922
52Insulin resistance_Homo sapiens_hsa049310.95267602
53Prostate cancer_Homo sapiens_hsa052150.94623818
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93416726
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93302449
56ErbB signaling pathway_Homo sapiens_hsa040120.92147126
57Renin secretion_Homo sapiens_hsa049240.92043047
58Glioma_Homo sapiens_hsa052140.91416497
59Endometrial cancer_Homo sapiens_hsa052130.90832354
60Bladder cancer_Homo sapiens_hsa052190.89848306
61Fatty acid metabolism_Homo sapiens_hsa012120.87957809
62Long-term depression_Homo sapiens_hsa047300.86833922
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86604830
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85452955
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.83563125
66Alcoholism_Homo sapiens_hsa050340.82945853
67Colorectal cancer_Homo sapiens_hsa052100.82944309
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.81629831
69Estrogen signaling pathway_Homo sapiens_hsa049150.81520005
70Thyroid hormone synthesis_Homo sapiens_hsa049180.81058424
71Viral myocarditis_Homo sapiens_hsa054160.81009499
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79974265
73cAMP signaling pathway_Homo sapiens_hsa040240.79085834
74Fatty acid biosynthesis_Homo sapiens_hsa000610.78942450
75Ovarian steroidogenesis_Homo sapiens_hsa049130.77868350
76Inositol phosphate metabolism_Homo sapiens_hsa005620.77356432
77Choline metabolism in cancer_Homo sapiens_hsa052310.77220106
78Toxoplasmosis_Homo sapiens_hsa051450.76774448
79Pancreatic secretion_Homo sapiens_hsa049720.76120606
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75321347
81Renal cell carcinoma_Homo sapiens_hsa052110.75007420
82Taste transduction_Homo sapiens_hsa047420.74780279
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73739465
84Serotonergic synapse_Homo sapiens_hsa047260.72683675
85Ras signaling pathway_Homo sapiens_hsa040140.72087951
86PPAR signaling pathway_Homo sapiens_hsa033200.71117919
87HTLV-I infection_Homo sapiens_hsa051660.70723769
88Nitrogen metabolism_Homo sapiens_hsa009100.69804274
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.69656821
90Bile secretion_Homo sapiens_hsa049760.67994766
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66653784
92Platelet activation_Homo sapiens_hsa046110.66307536
93Gap junction_Homo sapiens_hsa045400.64387680
94VEGF signaling pathway_Homo sapiens_hsa043700.64228640
95Fatty acid degradation_Homo sapiens_hsa000710.63696728
96Pancreatic cancer_Homo sapiens_hsa052120.63349468
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.61930936
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61711781
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.61536446
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.60635864
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58992139
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.58289059
103mTOR signaling pathway_Homo sapiens_hsa041500.58237270
104Arginine biosynthesis_Homo sapiens_hsa002200.57583509
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55869531
106AMPK signaling pathway_Homo sapiens_hsa041520.55641545
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55489298
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54605460
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.54204914
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53339902
111MAPK signaling pathway_Homo sapiens_hsa040100.53220564
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52907248
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52304857
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51396008
115Insulin signaling pathway_Homo sapiens_hsa049100.51135676
116Endocytosis_Homo sapiens_hsa041440.50771132
117GnRH signaling pathway_Homo sapiens_hsa049120.50155028
118Oxytocin signaling pathway_Homo sapiens_hsa049210.49477479
119Glucagon signaling pathway_Homo sapiens_hsa049220.48586113
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48235635
121Thyroid cancer_Homo sapiens_hsa052160.48091274
122Fatty acid elongation_Homo sapiens_hsa000620.48077725
123Gastric acid secretion_Homo sapiens_hsa049710.47052848
124Type II diabetes mellitus_Homo sapiens_hsa049300.46629714
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39818248
126Non-small cell lung cancer_Homo sapiens_hsa052230.38870491
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.38735511
128FoxO signaling pathway_Homo sapiens_hsa040680.37790801
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37726584
130Cocaine addiction_Homo sapiens_hsa050300.37151361
131Prolactin signaling pathway_Homo sapiens_hsa049170.34474941

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