CYP26C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cranial suture morphogenesis (GO:0060363)8.92097859
2pre-miRNA processing (GO:0031054)8.61217808
3lateral sprouting from an epithelium (GO:0060601)7.98482727
4planar cell polarity pathway involved in neural tube closure (GO:0090179)7.35755751
5paraxial mesoderm development (GO:0048339)6.97945176
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)6.79854816
7negative regulation of fatty acid metabolic process (GO:0045922)6.67891638
8rRNA catabolic process (GO:0016075)6.44133404
9craniofacial suture morphogenesis (GO:0097094)6.22849624
10convergent extension (GO:0060026)6.10773904
11histone H3-K36 demethylation (GO:0070544)5.99125847
12somatic stem cell division (GO:0048103)5.60466736
13outer ear morphogenesis (GO:0042473)5.44862228
14establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)5.32529925
15mitotic sister chromatid cohesion (GO:0007064)5.26947842
16lens fiber cell development (GO:0070307)5.26828748
17regulation of somitogenesis (GO:0014807)5.15586834
18somite rostral/caudal axis specification (GO:0032525)5.10363120
19digestive tract morphogenesis (GO:0048546)5.02330384
20positive regulation of synapse maturation (GO:0090129)4.94362904
21L-phenylalanine catabolic process (GO:0006559)4.94313974
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.94313974
23negative regulation of steroid biosynthetic process (GO:0010894)4.84266096
24aromatic amino acid family catabolic process (GO:0009074)4.83413379
25post-anal tail morphogenesis (GO:0036342)4.81800090
26L-phenylalanine metabolic process (GO:0006558)4.76136304
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.76136304
28complement activation, alternative pathway (GO:0006957)4.75454060
29kidney morphogenesis (GO:0060993)4.71699894
30negative regulation of steroid metabolic process (GO:0045939)4.66298797
31mannose metabolic process (GO:0006013)4.66054660
32glomerulus development (GO:0032835)4.65950944
33indolalkylamine catabolic process (GO:0046218)4.65655998
34tryptophan catabolic process (GO:0006569)4.65655998
35indole-containing compound catabolic process (GO:0042436)4.65655998
36establishment of tissue polarity (GO:0007164)4.64372224
37establishment of planar polarity (GO:0001736)4.64372224
38lung-associated mesenchyme development (GO:0060484)4.61328729
39regulation of fatty acid biosynthetic process (GO:0042304)4.60520912
40G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.48711246
41establishment or maintenance of apical/basal cell polarity (GO:0035088)4.48165885
42establishment or maintenance of bipolar cell polarity (GO:0061245)4.48165885
43tryptophan metabolic process (GO:0006568)4.48164879
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)4.44187445
45* fat-soluble vitamin catabolic process (GO:0042363)4.41261077
46* vitamin catabolic process (GO:0009111)4.41261077
47kynurenine metabolic process (GO:0070189)4.36064779
48negative regulation of cell fate specification (GO:0009996)4.24176905
49regulation of establishment of planar polarity (GO:0090175)4.22837672
50stem cell division (GO:0017145)4.21351629
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.15321054
52apical protein localization (GO:0045176)4.15205098
53regulation of cell fate specification (GO:0042659)4.13573040
54histone H3-K9 demethylation (GO:0033169)4.01805044
55lens morphogenesis in camera-type eye (GO:0002089)4.00753595
56regulation of protein activation cascade (GO:2000257)4.00056278
57non-canonical Wnt signaling pathway (GO:0035567)3.99883594
58urea metabolic process (GO:0019627)3.96091082
59urea cycle (GO:0000050)3.96091082
60negative regulation of fibrinolysis (GO:0051918)3.92899990
61ncRNA catabolic process (GO:0034661)3.88844756
62phosphate ion homeostasis (GO:0055062)3.87416672
63trivalent inorganic anion homeostasis (GO:0072506)3.87416672
64cochlea morphogenesis (GO:0090103)3.80892039
65regulation of complement activation (GO:0030449)3.76001269
66bile acid biosynthetic process (GO:0006699)3.74421585
67axon ensheathment in central nervous system (GO:0032291)3.72676764
68central nervous system myelination (GO:0022010)3.72676764
69coenzyme catabolic process (GO:0009109)3.72529506
70middle ear morphogenesis (GO:0042474)3.72085325
71regulation of synapse maturation (GO:0090128)3.71078423
72dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.70810343
73regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.64589645
74notochord development (GO:0030903)3.63423455
75cardiovascular system development (GO:0072358)3.60169477
76nitrogen cycle metabolic process (GO:0071941)3.59155184
77mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.58164171
78regulation of mesoderm development (GO:2000380)3.57137477
79dicarboxylic acid biosynthetic process (GO:0043650)3.57052813
80plasma lipoprotein particle clearance (GO:0034381)3.57041062
81homocysteine metabolic process (GO:0050667)3.56534651
82positive regulation of catenin import into nucleus (GO:0035413)3.54541751
83peptidyl-glutamic acid carboxylation (GO:0017187)3.53928789
84protein carboxylation (GO:0018214)3.53928789
85cell surface receptor signaling pathway involved in heart development (GO:0061311)3.51678056
86branching involved in salivary gland morphogenesis (GO:0060445)3.47779610
87regulation of fibrinolysis (GO:0051917)3.47690200
88alpha-linolenic acid metabolic process (GO:0036109)3.45238011
89protein-DNA complex disassembly (GO:0032986)3.43970483
90nucleosome disassembly (GO:0006337)3.43970483
91high-density lipoprotein particle remodeling (GO:0034375)3.41537930
92glyoxylate metabolic process (GO:0046487)3.38136498
93negative regulation of astrocyte differentiation (GO:0048712)3.37806463
94microtubule severing (GO:0051013)3.35101948
95negative regulation of histone methylation (GO:0031061)3.34986498
96positive regulation of vascular permeability (GO:0043117)3.33583969
97spinal cord association neuron differentiation (GO:0021527)3.31304537
98heparan sulfate proteoglycan metabolic process (GO:0030201)3.31040444
99nonmotile primary cilium assembly (GO:0035058)3.29703979
100aromatic amino acid family metabolic process (GO:0009072)3.29348564
101negative regulation of smoothened signaling pathway (GO:0045879)3.28672851
102regulation of cholesterol homeostasis (GO:2000188)3.22732663
103regulation of bile acid biosynthetic process (GO:0070857)3.22100578
104cell migration in hindbrain (GO:0021535)3.19432120
105serine family amino acid catabolic process (GO:0009071)3.18731885
106camera-type eye morphogenesis (GO:0048593)3.18108165
107limb development (GO:0060173)3.17274613
108appendage development (GO:0048736)3.17274613
109neural tube closure (GO:0001843)3.17138457
110cysteine metabolic process (GO:0006534)3.17067225
111regulation of gene silencing by RNA (GO:0060966)3.14391713
112regulation of posttranscriptional gene silencing (GO:0060147)3.14391713
113regulation of gene silencing by miRNA (GO:0060964)3.14391713
114plasma lipoprotein particle assembly (GO:0034377)3.13459500
115tube closure (GO:0060606)3.12477901
116negative regulation of sterol transport (GO:0032372)3.12446430
117negative regulation of cholesterol transport (GO:0032375)3.12446430
118phospholipid efflux (GO:0033700)3.10498571
119positive regulation of RNA splicing (GO:0033120)3.10361184
120indolalkylamine metabolic process (GO:0006586)3.10031985
121alpha-amino acid catabolic process (GO:1901606)3.09313673
122embryonic retina morphogenesis in camera-type eye (GO:0060059)3.08923497
123primitive streak formation (GO:0090009)3.08134953
124peptidyl-arginine omega-N-methylation (GO:0035247)3.06827732
125negative regulation of chondrocyte differentiation (GO:0032331)3.06007210
126bile acid metabolic process (GO:0008206)3.05370428
127regulation of non-canonical Wnt signaling pathway (GO:2000050)3.04497613
128neuronal stem cell maintenance (GO:0097150)3.04147749
129acylglycerol homeostasis (GO:0055090)3.02184949
130triglyceride homeostasis (GO:0070328)3.02184949
131imidazole-containing compound metabolic process (GO:0052803)3.01507368
132presynaptic membrane organization (GO:0097090)3.01102276
133sulfur amino acid catabolic process (GO:0000098)3.01031791
134chondrocyte proliferation (GO:0035988)3.00061697
135bile acid and bile salt transport (GO:0015721)2.98395540
136glutamate metabolic process (GO:0006536)2.94878325
137tyrosine metabolic process (GO:0006570)2.94731253
138reverse cholesterol transport (GO:0043691)2.92044414
139asymmetric protein localization (GO:0008105)2.90892370
140protein-lipid complex assembly (GO:0065005)2.90477209
141positive regulation of canonical Wnt signaling pathway (GO:0090263)2.90442896
142ventricular system development (GO:0021591)2.89881270
143negative regulation of interleukin-1 beta production (GO:0032691)2.89330189
144heterochromatin organization (GO:0070828)2.89115320
145positive regulation of respiratory burst (GO:0060267)2.88834898
146regulation of NFAT protein import into nucleus (GO:0051532)2.87552320
147pyrimidine nucleobase catabolic process (GO:0006208)2.86495394
148complement activation (GO:0006956)2.86320147
149presynaptic membrane assembly (GO:0097105)2.85908705
150protein-lipid complex remodeling (GO:0034368)2.84218989
151macromolecular complex remodeling (GO:0034367)2.84218989
152plasma lipoprotein particle remodeling (GO:0034369)2.84218989
153cholesterol biosynthetic process (GO:0006695)2.83274038
154sister chromatid cohesion (GO:0007062)2.82640082
155positive regulation of gastrulation (GO:2000543)2.82019022
156negative regulation of lipase activity (GO:0060192)2.81737468
157very-low-density lipoprotein particle assembly (GO:0034379)2.81643025
158peptidyl-arginine methylation (GO:0018216)2.81506855
159peptidyl-arginine N-methylation (GO:0035246)2.81506855
160positive regulation of fibroblast migration (GO:0010763)2.79970641
161anion homeostasis (GO:0055081)2.79558924
162regulation of histone H3-K9 methylation (GO:0051570)2.79006467
163cranial nerve development (GO:0021545)2.78897122
164cell differentiation involved in metanephros development (GO:0072202)2.78875152
165histone arginine methylation (GO:0034969)2.78669620
166purine nucleotide transport (GO:0015865)2.78061673
167negative regulation of cell fate commitment (GO:0010454)2.75687208
168spinal cord development (GO:0021510)2.75165838
169fatty acid transmembrane transport (GO:1902001)2.74788200
170chromatin silencing (GO:0006342)2.74219221
171fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.73499766
172glycine metabolic process (GO:0006544)2.73110133
173head development (GO:0060322)2.72690691
174establishment of apical/basal cell polarity (GO:0035089)2.72376114
175regulation of triglyceride catabolic process (GO:0010896)2.72237306
176regulation of cell fate commitment (GO:0010453)2.72112946
177organ growth (GO:0035265)2.71932851
178complement activation, classical pathway (GO:0006958)2.71681928
179seminiferous tubule development (GO:0072520)2.71579289
180negative regulation of glial cell differentiation (GO:0045686)2.71408814
181positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.70565306
182positive regulation of dendritic spine morphogenesis (GO:0061003)2.69757861
183negative regulation of lipid biosynthetic process (GO:0051055)2.69135368
184heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.68628523
185regulation of smoothened signaling pathway (GO:0008589)2.67910589
186dorsal/ventral axis specification (GO:0009950)2.67390018
187midbrain development (GO:0030901)2.67337599
188regulation of catenin import into nucleus (GO:0035412)2.67159492
189negative regulation of gene expression, epigenetic (GO:0045814)2.66936662
190inner ear receptor cell differentiation (GO:0060113)2.66415532
191mesenchymal to epithelial transition (GO:0060231)2.65629084
192axonal fasciculation (GO:0007413)2.65190159
193inner ear receptor cell development (GO:0060119)2.64761846
194bone morphogenesis (GO:0060349)2.61159054
195spermatid development (GO:0007286)2.60092405
196glomerular visceral epithelial cell development (GO:0072015)2.59080595
197negative regulation of fatty acid biosynthetic process (GO:0045717)10.3738156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.14367028
2EZH2_22144423_ChIP-Seq_EOC_Human5.96291491
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse5.09996901
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.86571469
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.30968354
6NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03272007
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.82498251
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.53888848
9STAT6_21828071_ChIP-Seq_BEAS2B_Human3.20293464
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.00548231
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.71076146
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.62539166
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.57453460
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.51776668
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.42400460
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.41807918
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.39203764
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.31819588
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28282900
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28282900
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.26910078
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.20976449
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.20976449
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.20976449
25IGF1R_20145208_ChIP-Seq_DFB_Human2.19669776
26TP53_16413492_ChIP-PET_HCT116_Human2.14014253
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.08090059
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.06676488
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06587605
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.05507060
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99054606
32* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91828634
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90283751
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87930773
35* EZH2_27294783_Chip-Seq_ESCs_Mouse1.87665122
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86023126
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.85943014
38* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82494907
39* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81219867
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.80212784
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74956871
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.68050044
43* ISL1_27105846_Chip-Seq_CPCs_Mouse1.67440945
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61812476
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58582946
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56802074
47CLOCK_20551151_ChIP-Seq_293T_Human1.55728747
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55683660
49IRF1_19129219_ChIP-ChIP_H3396_Human1.54466754
50RNF2_27304074_Chip-Seq_NSC_Mouse1.54070224
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48987602
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47595687
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.47227841
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46782158
55* RING1B_27294783_Chip-Seq_ESCs_Mouse1.46560966
56FOXA2_19822575_ChIP-Seq_HepG2_Human1.45365506
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43962469
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42239295
59AR_21572438_ChIP-Seq_LNCaP_Human1.42034173
60CTCF_27219007_Chip-Seq_Bcells_Human1.40576128
61SMAD3_21741376_ChIP-Seq_ESCs_Human1.40124508
62KDM2B_26808549_Chip-Seq_K562_Human1.39165902
63DROSHA_22980978_ChIP-Seq_HELA_Human1.34749747
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.33909330
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30640770
66* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28755855
67FUS_26573619_Chip-Seq_HEK293_Human1.28626709
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28092677
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27833465
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27724953
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27537942
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.27073928
73ELK4_26923725_Chip-Seq_MESODERM_Mouse1.26831820
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25313960
75RUNX1_26923725_Chip-Seq_HPCs_Mouse1.23031416
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21964681
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20333717
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19326167
79WDR5_24793694_ChIP-Seq_LNCAP_Human1.18579903
80REST_21632747_ChIP-Seq_MESCs_Mouse1.16825764
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.16603797
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.16285636
83TAF15_26573619_Chip-Seq_HEK293_Human1.13812424
84POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11961393
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11246783
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11179173
87GATA6_25053715_ChIP-Seq_YYC3_Human1.10942098
88* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10023484
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.09179059
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.07023897
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06471457
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06471457
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06457029
94BCAT_22108803_ChIP-Seq_LS180_Human1.05420171
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05295110
96FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04905788
97* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04486142
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04019729
99TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03037854
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01707968
101RXR_22108803_ChIP-Seq_LS180_Human1.00372917
102REST_18959480_ChIP-ChIP_MESCs_Mouse0.99767965
103DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98678220
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98202753
105TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97754562
106TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97382028
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97236409
108POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96641688
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95197867
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95052931
111BP1_19119308_ChIP-ChIP_Hs578T_Human0.94868047
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94197347
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94110706
114* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93765158
115KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93661649
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93634440
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93441320
118* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93335489
119* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93322670
120HNF4A_19822575_ChIP-Seq_HepG2_Human0.93037745
121EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92905688
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92375399
123* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92157395
124CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91742445
125TP63_19390658_ChIP-ChIP_HaCaT_Human0.91455996
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91321514
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91046131
128* KLF4_19829295_ChIP-Seq_ESCs_Human0.90739482
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90332890
130AR_19668381_ChIP-Seq_PC3_Human0.90326428
131RARB_27405468_Chip-Seq_BRAIN_Mouse0.89432059
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89193187
133EGR1_19032775_ChIP-ChIP_M12_Human0.88887668
134TCF7_22412390_ChIP-Seq_EML_Mouse0.87862133
135* TBL1_22424771_ChIP-Seq_293T_Human0.86668016
136ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86250619
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86206915
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.86141440
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84824952
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84473926
141CDX2_20551321_ChIP-Seq_CACO-2_Human0.83688948
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82840557
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82840557
144OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82774605
145CREB1_26743006_Chip-Seq_LNCaP_Human0.81468425
146SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80444793
147ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80132029
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78595160
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78015766
150VDR_21846776_ChIP-Seq_THP-1_Human0.76868188
151RNF2_27304074_Chip-Seq_ESCs_Mouse0.76698991
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75470024
153SMAD3_21741376_ChIP-Seq_EPCs_Human0.75281034
154SOX3_22085726_ChIP-Seq_NPCs_Mouse0.73890046
155TCF4_22108803_ChIP-Seq_LS180_Human0.73183159
156NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.72637038
157SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72274665
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.71624727
159RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.71012844
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.70941711
161SRY_22984422_ChIP-ChIP_TESTIS_Rat0.70925903
162HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69507656
163TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.69352548
164KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.69263894
165Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69235782
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.69213608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.89136425
2MP0002139_abnormal_hepatobiliary_system5.91744083
3MP0005360_urolithiasis5.61081143
4MP0005083_abnormal_biliary_tract4.41578571
5MP0005365_abnormal_bile_salt4.34139748
6MP0005085_abnormal_gallbladder_physiolo4.29613816
7MP0005377_hearing/vestibular/ear_phenot4.27662468
8MP0003878_abnormal_ear_physiology4.27662468
9MP0008875_abnormal_xenobiotic_pharmacok3.25477816
10MP0003136_yellow_coat_color2.95761335
11MP0009840_abnormal_foam_cell2.89879636
12MP0003122_maternal_imprinting2.87633738
13MP0000537_abnormal_urethra_morphology2.66021728
14MP0003119_abnormal_digestive_system2.60662496
15MP0006292_abnormal_olfactory_placode2.57680448
16MP0001299_abnormal_eye_distance/2.57246151
17MP0010329_abnormal_lipoprotein_level2.39772043
18MP0003195_calcinosis2.38883060
19MP0002249_abnormal_larynx_morphology2.38439598
20MP0005171_absent_coat_pigmentation2.29857280
21MP0003890_abnormal_embryonic-extraembry2.23052464
22MP0003705_abnormal_hypodermis_morpholog2.21011914
23MP0003252_abnormal_bile_duct2.20741665
24MP0003868_abnormal_feces_composition2.18778880
25MP0009780_abnormal_chondrocyte_physiolo2.12931908
26MP0000569_abnormal_digit_pigmentation2.03696027
27MP0004858_abnormal_nervous_system2.00663862
28MP0005670_abnormal_white_adipose1.93291210
29MP0003941_abnormal_skin_development1.92467003
30MP0002282_abnormal_trachea_morphology1.91333078
31MP0005076_abnormal_cell_differentiation1.88210472
32MP0009250_abnormal_appendicular_skeleto1.84384329
33MP0005257_abnormal_intraocular_pressure1.80451071
34MP0003935_abnormal_craniofacial_develop1.80305337
35MP0005423_abnormal_somatic_nervous1.77421702
36MP0010030_abnormal_orbit_morphology1.62949310
37MP0003937_abnormal_limbs/digits/tail_de1.57946793
38MP0002009_preneoplasia1.53606167
39MP0000609_abnormal_liver_physiology1.50206350
40MP0004185_abnormal_adipocyte_glucose1.48131954
41MP0000579_abnormal_nail_morphology1.44315638
42MP0003121_genomic_imprinting1.43349641
43MP0002932_abnormal_joint_morphology1.42791872
44MP0009672_abnormal_birth_weight1.40176433
45MP0005332_abnormal_amino_acid1.36885040
46MP0002234_abnormal_pharynx_morphology1.35662772
47MP0001286_abnormal_eye_development1.35457566
48MP0001984_abnormal_olfaction1.34689643
49MP0000026_abnormal_inner_ear1.33670578
50MP0002184_abnormal_innervation1.32176276
51MP0004019_abnormal_vitamin_homeostasis1.31141940
52MP0000678_abnormal_parathyroid_gland1.30280396
53MP0001346_abnormal_lacrimal_gland1.30216049
54MP0009703_decreased_birth_body1.29967872
55MP0002751_abnormal_autonomic_nervous1.29889848
56MP0002089_abnormal_postnatal_growth/wei1.26754772
57MP0003315_abnormal_perineum_morphology1.26455353
58MP0001485_abnormal_pinna_reflex1.25576979
59MP0002697_abnormal_eye_size1.22768072
60MP0004197_abnormal_fetal_growth/weight/1.21913812
61MP0000049_abnormal_middle_ear1.20894217
62MP0000955_abnormal_spinal_cord1.20731045
63MP0001666_abnormal_nutrient_absorption1.19864493
64MP0003385_abnormal_body_wall1.19677486
65MP0009278_abnormal_bone_marrow1.18432986
66MP0002102_abnormal_ear_morphology1.13030659
67MP0002152_abnormal_brain_morphology1.12489425
68MP0005410_abnormal_fertilization1.11900419
69MP0003880_abnormal_central_pattern1.11003573
70MP0002118_abnormal_lipid_homeostasis1.10256586
71MP0003942_abnormal_urinary_system1.08118124
72MP0003755_abnormal_palate_morphology1.06705659
73MP0000631_abnormal_neuroendocrine_gland1.06263614
74MP0002111_abnormal_tail_morphology1.04205971
75MP0002081_perinatal_lethality0.99857734
76MP0005197_abnormal_uvea_morphology0.98353981
77MP0005248_abnormal_Harderian_gland0.97372198
78MP0005409_darkened_coat_color0.96963499
79MP0005391_vision/eye_phenotype0.95466462
80MP0004272_abnormal_basement_membrane0.94313907
81MP0005666_abnormal_adipose_tissue0.91572283
82MP0003115_abnormal_respiratory_system0.90973946
83MP0002925_abnormal_cardiovascular_devel0.90497878
84MP0005395_other_phenotype0.90427625
85MP0002882_abnormal_neuron_morphology0.90273720
86MP0003718_maternal_effect0.89430125
87MP0000762_abnormal_tongue_morphology0.88100659
88MP0002127_abnormal_cardiovascular_syste0.87728857
89MP0005187_abnormal_penis_morphology0.87295545
90MP0001958_emphysema0.86335925
91MP0000598_abnormal_liver_morphology0.86239620
92MP0000428_abnormal_craniofacial_morphol0.85414070
93MP0000604_amyloidosis0.84258996
94MP0003693_abnormal_embryo_hatching0.83919263
95MP0006276_abnormal_autonomic_nervous0.83477544
96MP0000534_abnormal_ureter_morphology0.83039132
97MP0001851_eye_inflammation0.83002799
98MP0003698_abnormal_male_reproductive0.82739725
99MP0002938_white_spotting0.81596021
100MP0004742_abnormal_vestibular_system0.81514096
101MP0001340_abnormal_eyelid_morphology0.80398757
102MP0004811_abnormal_neuron_physiology0.79903254
103MP0002168_other_aberrant_phenotype0.79402493
104MP0004133_heterotaxia0.78772340
105MP0008932_abnormal_embryonic_tissue0.78627870
106MP0009697_abnormal_copulation0.78444838
107MP0002752_abnormal_somatic_nervous0.78353595
108MP0006072_abnormal_retinal_apoptosis0.78299444
109MP0001968_abnormal_touch/_nociception0.78220922
110MP0005508_abnormal_skeleton_morphology0.77949903
111MP0003861_abnormal_nervous_system0.77586760
112MP0001502_abnormal_circadian_rhythm0.77543042
113MP0004270_analgesia0.77470109
114MP0004233_abnormal_muscle_weight0.76632208
115MP0010368_abnormal_lymphatic_system0.76539965
116MP0008961_abnormal_basal_metabolism0.76471937
117MP0002114_abnormal_axial_skeleton0.74731429
118MP0000266_abnormal_heart_morphology0.74582257
119MP0002109_abnormal_limb_morphology0.74067053
120MP0003984_embryonic_growth_retardation0.73852914
121MP0002116_abnormal_craniofacial_bone0.73682623
122MP0001486_abnormal_startle_reflex0.73459331
123MP0005319_abnormal_enzyme/_coenzyme0.73101355
124MP0002085_abnormal_embryonic_tissue0.72469574
125MP0009053_abnormal_anal_canal0.72366587
126MP0000163_abnormal_cartilage_morphology0.72122441
127MP0001963_abnormal_hearing_physiology0.72049434
128MP0003787_abnormal_imprinting0.71896618
129MP0003656_abnormal_erythrocyte_physiolo0.70169301
130MP0002088_abnormal_embryonic_growth/wei0.69416988
131MP0002132_abnormal_respiratory_system0.68749673
132MP0001849_ear_inflammation0.67545474
133MP0003566_abnormal_cell_adhesion0.67211236
134MP0000432_abnormal_head_morphology0.67044172
135MP0005551_abnormal_eye_electrophysiolog0.67035524
136MP0003806_abnormal_nucleotide_metabolis0.66751846
137MP0008789_abnormal_olfactory_epithelium0.64104779
138MP0002233_abnormal_nose_morphology0.63625431
139MP0002084_abnormal_developmental_patter0.62119918
140MP0001293_anophthalmia0.62020487
141MP0003938_abnormal_ear_development0.60703200
142MP0002653_abnormal_ependyma_morphology0.57961987
143MP0002092_abnormal_eye_morphology0.57591465
144MP0008775_abnormal_heart_ventricle0.57093485
145MP0003567_abnormal_fetal_cardiomyocyte0.56357881
146MP0002135_abnormal_kidney_morphology0.55130364
147MP0003329_amyloid_beta_deposits0.55112850
148MP0004134_abnormal_chest_morphology0.54902584
149MP0005499_abnormal_olfactory_system0.54393537
150MP0005394_taste/olfaction_phenotype0.54393537
151MP0004859_abnormal_synaptic_plasticity0.54260681
152MP0005381_digestive/alimentary_phenotyp0.53902186
153MP0005380_embryogenesis_phenotype0.53777469
154MP0001672_abnormal_embryogenesis/_devel0.53777469
155MP0009763_increased_sensitivity_to0.53744698
156MP0000778_abnormal_nervous_system0.53234202
157MP0010234_abnormal_vibrissa_follicle0.52330283
158MP0001790_abnormal_immune_system0.52193141
159MP0005387_immune_system_phenotype0.52193141

Predicted human phenotypes

RankGene SetZ-score
1Coronal craniosynostosis (HP:0004440)5.46924564
2Prolonged partial thromboplastin time (HP:0003645)5.18834067
3Aplasia involving bones of the upper limbs (HP:0009823)4.81089081
4Aplasia of the phalanges of the hand (HP:0009802)4.81089081
5Aplasia involving bones of the extremities (HP:0009825)4.81089081
6Partial duplication of thumb phalanx (HP:0009944)4.72159212
7Back pain (HP:0003418)4.69675723
8Deep venous thrombosis (HP:0002625)4.68957937
9Conjugated hyperbilirubinemia (HP:0002908)4.67374315
10Systemic lupus erythematosus (HP:0002725)4.67212491
11Cerebellar dysplasia (HP:0007033)4.32573020
12Partial duplication of the phalanx of hand (HP:0009999)4.18512027
13Skull defect (HP:0001362)4.02758333
14Rib fusion (HP:0000902)3.98407129
15Hyperlipoproteinemia (HP:0010980)3.94241735
16Abnormality of the middle phalanges of the toes (HP:0010183)3.89984476
17Intrahepatic cholestasis (HP:0001406)3.89270053
18Complement deficiency (HP:0004431)3.87042338
19Myelomeningocele (HP:0002475)3.83608928
20Cutaneous finger syndactyly (HP:0010554)3.55305738
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.53421233
22Neonatal short-limb short stature (HP:0008921)3.50145881
23Xanthomatosis (HP:0000991)3.45491915
24Hemivertebrae (HP:0002937)3.31857749
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.30828318
26Aqueductal stenosis (HP:0002410)3.29365727
27Abnormality of complement system (HP:0005339)3.25208795
28Cutaneous syndactyly (HP:0012725)3.17090057
29Mixed hearing impairment (HP:0000410)3.12084283
30Preaxial foot polydactyly (HP:0001841)3.11161159
313-Methylglutaconic aciduria (HP:0003535)3.05577830
32Hypoplasia of the pons (HP:0012110)3.05516873
33Abnormality of abdominal situs (HP:0011620)3.03855424
34Abdominal situs inversus (HP:0003363)3.03855424
35Epidermoid cyst (HP:0200040)3.01848043
36Trigonocephaly (HP:0000243)3.01264077
37Hyperventilation (HP:0002883)3.00384160
38Duplication of thumb phalanx (HP:0009942)2.94665812
39Bronchomalacia (HP:0002780)2.92907678
40Synostosis of carpal bones (HP:0005048)2.92740738
41Abnormality of pyrimidine metabolism (HP:0004353)2.89065128
42Broad metatarsal (HP:0001783)2.88426577
43Choanal stenosis (HP:0000452)2.86273813
44Joint hemorrhage (HP:0005261)2.85765910
45Broad hallux (HP:0010055)2.84176949
46Fair hair (HP:0002286)2.83398180
47Abnormality of incisor morphology (HP:0011063)2.78661689
48Abnormality of the lacrimal duct (HP:0011481)2.76921471
49Hyperammonemia (HP:0001987)2.68588398
50Heterotopia (HP:0002282)2.67769038
51Broad thumb (HP:0011304)2.67670575
52Hypobetalipoproteinemia (HP:0003563)2.65356408
53Polycythemia (HP:0001901)2.64814252
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62138568
55Short 4th metacarpal (HP:0010044)2.62138568
56Enlarged kidneys (HP:0000105)2.61116883
57Broad toe (HP:0001837)2.60191440
58Abnormality of sulfur amino acid metabolism (HP:0004339)2.57372579
59Abnormality of the pons (HP:0007361)2.55110674
60Uterine leiomyosarcoma (HP:0002891)2.54049929
61Leiomyosarcoma (HP:0100243)2.54049929
62Humeroradial synostosis (HP:0003041)2.53993176
63Synostosis involving the elbow (HP:0003938)2.53993176
64Thickened helices (HP:0000391)2.51936741
65Abnormality of the intrinsic pathway (HP:0010989)2.49485335
66Renal cell carcinoma (HP:0005584)2.46917178
67Hypoplasia of the ulna (HP:0003022)2.45875986
68Abnormality of the phalanges of the 2nd finger (HP:0009541)2.44093323
69Megalencephaly (HP:0001355)2.41417379
70Exotropia (HP:0000577)2.41416001
71Hepatocellular carcinoma (HP:0001402)2.41218602
72Abnormality of the nasolacrimal system (HP:0000614)2.40934564
73Partial agenesis of the corpus callosum (HP:0001338)2.39556695
74Aplasia involving forearm bones (HP:0009822)2.39413610
75Absent forearm bone (HP:0003953)2.39413610
76Urethral obstruction (HP:0000796)2.39153948
77Pseudobulbar signs (HP:0002200)2.39007443
78Absent radius (HP:0003974)2.38675224
79Septo-optic dysplasia (HP:0100842)2.38234101
80Stroke (HP:0001297)2.37749438
81Supernumerary ribs (HP:0005815)2.36164785
82Broad phalanges of the hand (HP:0009768)2.34135798
83Short middle phalanx of finger (HP:0005819)2.33405939
84Abnormality of the antihelix (HP:0009738)2.32723112
85Carpal synostosis (HP:0009702)2.31789173
86Hemangiomatosis (HP:0007461)2.30230040
87Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.28506016
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28171814
89Tracheomalacia (HP:0002779)2.27928590
90Shallow orbits (HP:0000586)2.26928023
91Oligodactyly (hands) (HP:0001180)2.26494180
92Abnormality of the incisor (HP:0000676)2.24323551
93Morphological abnormality of the middle ear (HP:0008609)2.24124530
94Arnold-Chiari malformation (HP:0002308)2.24071574
95Abnormality of the common coagulation pathway (HP:0010990)2.23583047
96Aplasia/Hypoplasia of the ulna (HP:0006495)2.23156640
97Alacrima (HP:0000522)2.22514418
98Broad finger (HP:0001500)2.21609426
99Abnormality of the 2nd finger (HP:0004100)2.21069046
100Anophthalmia (HP:0000528)2.18621188
101Abnormality of the lumbar spine (HP:0100712)2.17701084
102Turricephaly (HP:0000262)2.16890137
103Vertebral fusion (HP:0002948)2.16117809
104Supernumerary bones of the axial skeleton (HP:0009144)2.15991677
105Bell-shaped thorax (HP:0001591)2.15944546
106Abnormality of the labia minora (HP:0012880)2.13741029
107Split foot (HP:0001839)2.13578827
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13357355
109Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12496158
110Nasolacrimal duct obstruction (HP:0000579)2.11777675
111Skin nodule (HP:0200036)2.11708460
112Aplasia/Hypoplasia of the sternum (HP:0006714)2.10414484
113Hyperinsulinemic hypoglycemia (HP:0000825)2.09610253
114Optic nerve hypoplasia (HP:0000609)2.09470620
115Disproportionate tall stature (HP:0001519)2.09217443
116Aplasia cutis congenita (HP:0001057)2.07955492
117Cupped ear (HP:0000378)2.07322442
118Hypoglycemic seizures (HP:0002173)2.06079893
119Abnormality of the septum pellucidum (HP:0007375)2.05342786
120Down-sloping shoulders (HP:0200021)2.05335333
121Absent septum pellucidum (HP:0001331)2.05227739
122Broad phalanx (HP:0006009)2.04826934
123Visceral angiomatosis (HP:0100761)2.04665862
124Abnormality of the 4th metacarpal (HP:0010012)2.03378343
125Esophageal atresia (HP:0002032)2.03360121
126Vitreoretinal degeneration (HP:0000655)2.02737449
127Hyperacusis (HP:0010780)2.01858693
128Broad long bones (HP:0005622)1.99073869
129Abnormality of permanent molar morphology (HP:0011071)1.98708246
130Abnormality of the dental root (HP:0006486)1.98708246
131Taurodontia (HP:0000679)1.98708246
132Midline defect of the nose (HP:0004122)1.98667311
133Meningocele (HP:0002435)1.98025725
134Intestinal fistula (HP:0100819)1.96783217
135Bilateral microphthalmos (HP:0007633)1.96319626
136J-shaped sella turcica (HP:0002680)1.93786038
137Ectopic anus (HP:0004397)1.91869489
138Hypolipoproteinemia (HP:0010981)1.91600247
139Abnormality of the distal phalanx of the thumb (HP:0009617)1.91486368
140Broad distal phalanx of finger (HP:0009836)1.90649908
141Nonimmune hydrops fetalis (HP:0001790)1.89494467
142Synostosis involving bones of the hand (HP:0004278)1.88880325
143Proximal tubulopathy (HP:0000114)1.88544648
144Glomerulonephritis (HP:0000099)1.88025042
145Abnormal number of incisors (HP:0011064)1.87423871
146Spastic diplegia (HP:0001264)1.86846232
147Myocardial infarction (HP:0001658)1.86590838
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86042354
1492-3 toe syndactyly (HP:0004691)1.85893240
150Abnormality of the pubic bones (HP:0003172)1.85493993
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84389497
152Abnormality of molar morphology (HP:0011070)1.83820032
153Abnormality of molar (HP:0011077)1.83820032
154Vascular calcification (HP:0004934)1.83508548
155Stenosis of the external auditory canal (HP:0000402)1.83297506
156Tubular atrophy (HP:0000092)1.83216966
157Hypoalphalipoproteinemia (HP:0003233)1.82859975
158Anteriorly placed anus (HP:0001545)1.82771551
159Abnormality of the parathyroid morphology (HP:0011766)1.81614747
160Abnormality of the dental pulp (HP:0006479)1.81235551
161Ulnar bowing (HP:0003031)1.81053546
162Recurrent gram-negative bacterial infections (HP:0005420)1.80411441
163Subacute progressive viral hepatitis (HP:0006572)1.80366932
164Decreased lacrimation (HP:0000633)1.80298615
165High anterior hairline (HP:0009890)1.80054870
166Oligodactyly (HP:0012165)1.79652729
167Hepatoblastoma (HP:0002884)1.79027078
168Esophageal varix (HP:0002040)1.78902365
169Omphalocele (HP:0001539)1.78136611
170Buphthalmos (HP:0000557)1.77562812
171Gingival bleeding (HP:0000225)1.77537584
172Rectal fistula (HP:0100590)1.76344566
173Rectovaginal fistula (HP:0000143)1.76344566
174Hypercholesterolemia (HP:0003124)1.76269242
175Elfin facies (HP:0004428)1.76231406
176Ketosis (HP:0001946)1.74290117
177Vaginal fistula (HP:0004320)1.74144813
178Transitional cell carcinoma of the bladder (HP:0006740)1.70770899
179Asymmetric septal hypertrophy (HP:0001670)1.70353872
180Hyperbilirubinemia (HP:0002904)1.69782024
181Ileus (HP:0002595)1.68095357
182Abnormality of methionine metabolism (HP:0010901)1.67960073
183Abnormality of nucleobase metabolism (HP:0010932)1.67824640
184Missing ribs (HP:0000921)1.67595376
185Abnormal social behavior (HP:0012433)1.67441345
186Impaired social interactions (HP:0000735)1.67441345
187Generalized hypopigmentation of hair (HP:0011358)1.66027015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK7.72017495
2FGFR25.15771626
3CDK124.61187019
4TYRO33.42463784
5TYK23.35323799
6BRD43.29677251
7PKN23.12130675
8FGFR32.63545761
9INSRR2.47204453
10CAMK1D2.28503660
11MKNK22.21511694
12MAP3K92.14824862
13DYRK1B2.11997585
14MAPK112.10360629
15CAMK1G2.07664339
16NTRK21.96856473
17MAP3K101.82928424
18EPHA41.82302973
19KSR11.80579335
20IRAK31.79474358
21MAP3K21.73499329
22PLK21.62797742
23PLK41.61296887
24DAPK21.55295179
25DYRK21.46734229
26LATS21.40874606
27CDK191.36281410
28NEK11.36017798
29MARK11.29648998
30BCR1.27932879
31SRPK11.26286516
32PTK61.24462222
33EPHB21.20239033
34DYRK1A1.17665216
35MAPK151.15419156
36CDK31.09294059
37ERN11.08427929
38PDGFRA1.08196995
39SIK11.08128052
40MTOR1.06103039
41LATS11.05718747
42FLT31.05232272
43SIK20.98684847
44FES0.97540378
45TRIB30.97528622
46NEK20.96765152
47TIE10.96097315
48EPHA30.95524396
49ALK0.94908549
50CDC70.89605432
51TESK20.89394796
52ERBB20.89370041
53MAP2K30.86082505
54WNK10.84241813
55TTN0.83185352
56STK38L0.80322274
57MAP3K130.79873852
58HCK0.79237918
59FGFR40.77346909
60MAP2K70.74699597
61SGK2230.74623086
62SGK4940.74623086
63MINK10.73004551
64NTRK10.72519315
65FGFR10.70319192
66KSR20.70045119
67ZAK0.68505152
68ICK0.65588821
69CDK60.65105175
70NEK60.64325456
71MOS0.64154630
72MST1R0.63867029
73RPS6KA40.60346120
74CHEK20.58687024
75RIPK10.57528743
76CAMK2D0.56787279
77CSNK1A1L0.56769213
78BMX0.56352029
79MAPK100.56139042
80SGK30.54561128
81PRKD30.54457611
82STK110.54421102
83BMPR1B0.53891388
84MAP4K10.53707017
85PDGFRB0.53122831
86CDK70.53113635
87CDK11A0.52420052
88RET0.51925831
89PAK60.51738644
90MAPK80.50248795
91RPS6KA10.49804699
92PAK30.49062528
93MAP2K40.49045542
94PASK0.48767832
95FER0.47871719
96CSNK1D0.47729352
97MARK20.47106321
98EEF2K0.46477229
99CDK150.44413281
100CLK10.44203595
101PAK20.42969301
102TGFBR10.42737614
103GSK3B0.42538041
104CSNK1G10.42141200
105CDK180.41889005
106MET0.41594467
107RPS6KA20.41436784
108CDK20.41213347
109CDK10.40997347
110CDK90.40745250
111RPS6KC10.39826353
112RPS6KL10.39826353
113CSNK1G30.39464618
114CSNK1E0.38837082
115MAP3K40.38158119
116STK30.37996293
117FGR0.37957257
118AKT10.37801619
119EGFR0.37283243
120PNCK0.36820344
121ERBB40.36698539
122CSF1R0.35738730
123DAPK30.35636633
124TTK0.35415505
125MKNK10.34740566
126MAP3K70.34691861
127PRKCE0.34388699
128CDC42BPA0.34376320
129PTK20.34001739
130ATR0.33659275
131NTRK30.33384576
132ATM0.33357840
133MAP3K30.33159576
134PAK40.33033803
135CSNK1A10.32986527
136CSNK1G20.32111438
137IGF1R0.31888140
138CAMK40.31382049
139JAK20.31041937
140PRKCZ0.30957818
141TXK0.30537835
142PRKG10.30501313
143BCKDK0.29998754
144PRKDC0.29871511
145CDK50.29859677
146MAPK90.29579750
147YES10.29578807
148MAPK10.29514489
149MARK30.29408049
150MAPK140.29345478
151SGK20.28985388
152CHEK10.27597125
153PKN10.27576677
154TAOK30.27270345

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.20835209
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.98110918
3Nitrogen metabolism_Homo sapiens_hsa009103.44370441
4Arginine biosynthesis_Homo sapiens_hsa002203.17568250
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.16431512
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.10569923
7Complement and coagulation cascades_Homo sapiens_hsa046103.05040111
8Hippo signaling pathway_Homo sapiens_hsa043903.01640882
9Staphylococcus aureus infection_Homo sapiens_hsa051502.80044767
10Tryptophan metabolism_Homo sapiens_hsa003802.40948548
11mRNA surveillance pathway_Homo sapiens_hsa030152.28732359
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18186906
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.11370498
14Lysine degradation_Homo sapiens_hsa003102.08635374
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00249061
16Melanogenesis_Homo sapiens_hsa049161.96875158
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.95428238
18Caffeine metabolism_Homo sapiens_hsa002321.92875156
19Histidine metabolism_Homo sapiens_hsa003401.76412788
20* Retinol metabolism_Homo sapiens_hsa008301.75410074
21Phenylalanine metabolism_Homo sapiens_hsa003601.72596439
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60999011
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.60352855
24Long-term depression_Homo sapiens_hsa047301.60217633
25Tight junction_Homo sapiens_hsa045301.58354131
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57896799
27Biosynthesis of amino acids_Homo sapiens_hsa012301.55475697
28Selenocompound metabolism_Homo sapiens_hsa004501.53463907
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.52006930
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48939509
31Peroxisome_Homo sapiens_hsa041461.47926225
32Morphine addiction_Homo sapiens_hsa050321.45437739
33beta-Alanine metabolism_Homo sapiens_hsa004101.41906841
34Circadian entrainment_Homo sapiens_hsa047131.41438575
35Butanoate metabolism_Homo sapiens_hsa006501.39725777
36Fatty acid degradation_Homo sapiens_hsa000711.37657871
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35921828
38Bile secretion_Homo sapiens_hsa049761.34930089
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33261314
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25231632
41Rap1 signaling pathway_Homo sapiens_hsa040151.24421586
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24069930
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21606273
44Nicotine addiction_Homo sapiens_hsa050331.21262263
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18792310
46Alcoholism_Homo sapiens_hsa050341.17450611
47Pathways in cancer_Homo sapiens_hsa052001.17213851
48TGF-beta signaling pathway_Homo sapiens_hsa043501.16709910
49Cholinergic synapse_Homo sapiens_hsa047251.14979240
50Taste transduction_Homo sapiens_hsa047421.14938153
51ECM-receptor interaction_Homo sapiens_hsa045121.12671269
52Starch and sucrose metabolism_Homo sapiens_hsa005001.11639073
53Chemical carcinogenesis_Homo sapiens_hsa052041.10556993
54PPAR signaling pathway_Homo sapiens_hsa033201.09973543
55Tyrosine metabolism_Homo sapiens_hsa003501.05662170
56Dorso-ventral axis formation_Homo sapiens_hsa043201.03769191
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.03140209
58Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02138255
59One carbon pool by folate_Homo sapiens_hsa006701.01563270
60GABAergic synapse_Homo sapiens_hsa047270.98426195
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.98425973
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98141665
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.97961266
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97238485
65Ras signaling pathway_Homo sapiens_hsa040140.94975328
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92693552
67Inositol phosphate metabolism_Homo sapiens_hsa005620.92597538
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91801046
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91766407
70Dopaminergic synapse_Homo sapiens_hsa047280.91469582
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.91325922
72MAPK signaling pathway_Homo sapiens_hsa040100.90773386
73Choline metabolism in cancer_Homo sapiens_hsa052310.90489071
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90283256
75Spliceosome_Homo sapiens_hsa030400.90126649
76Folate biosynthesis_Homo sapiens_hsa007900.86095759
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84621080
78ABC transporters_Homo sapiens_hsa020100.83690953
79VEGF signaling pathway_Homo sapiens_hsa043700.82551252
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81896267
81Type II diabetes mellitus_Homo sapiens_hsa049300.79985504
82Long-term potentiation_Homo sapiens_hsa047200.79125196
83Fatty acid metabolism_Homo sapiens_hsa012120.78978325
84Focal adhesion_Homo sapiens_hsa045100.78650302
85Fat digestion and absorption_Homo sapiens_hsa049750.78520662
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76392769
87Sulfur metabolism_Homo sapiens_hsa009200.74573588
88Bladder cancer_Homo sapiens_hsa052190.72884488
89Arginine and proline metabolism_Homo sapiens_hsa003300.72141676
90B cell receptor signaling pathway_Homo sapiens_hsa046620.71528997
91Cell cycle_Homo sapiens_hsa041100.71227798
92RNA transport_Homo sapiens_hsa030130.71113001
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70004966
94cAMP signaling pathway_Homo sapiens_hsa040240.69763727
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69669671
96Serotonergic synapse_Homo sapiens_hsa047260.68911093
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66418727
98Estrogen signaling pathway_Homo sapiens_hsa049150.66014838
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65711940
100Fructose and mannose metabolism_Homo sapiens_hsa000510.65680511
101Calcium signaling pathway_Homo sapiens_hsa040200.65640862
102Oxytocin signaling pathway_Homo sapiens_hsa049210.65560384
103Protein digestion and absorption_Homo sapiens_hsa049740.65304880
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65074351
105mTOR signaling pathway_Homo sapiens_hsa041500.64974487
106Systemic lupus erythematosus_Homo sapiens_hsa053220.63473721
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61315895
108Non-homologous end-joining_Homo sapiens_hsa034500.61079902
109Oocyte meiosis_Homo sapiens_hsa041140.60770964
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60189857
111Pyruvate metabolism_Homo sapiens_hsa006200.58666274
112Carbon metabolism_Homo sapiens_hsa012000.58223369
113Osteoclast differentiation_Homo sapiens_hsa043800.58134291
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57600435
115Prostate cancer_Homo sapiens_hsa052150.57541079
116Axon guidance_Homo sapiens_hsa043600.56477366
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56344831
118Basal transcription factors_Homo sapiens_hsa030220.55953771
119Non-small cell lung cancer_Homo sapiens_hsa052230.55386518
120Notch signaling pathway_Homo sapiens_hsa043300.54941684
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54680542
122Prion diseases_Homo sapiens_hsa050200.54465935
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53596836
124Propanoate metabolism_Homo sapiens_hsa006400.52349286
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51384914
126Insulin resistance_Homo sapiens_hsa049310.48955533
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47139661
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47023620
129Prolactin signaling pathway_Homo sapiens_hsa049170.46429187
130Renal cell carcinoma_Homo sapiens_hsa052110.45340913
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44488628
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43537486
133Dilated cardiomyopathy_Homo sapiens_hsa054140.43356350
134Salivary secretion_Homo sapiens_hsa049700.41964368
135Platelet activation_Homo sapiens_hsa046110.41894633
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.41878436
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41433550
138Glucagon signaling pathway_Homo sapiens_hsa049220.41056646
139Cocaine addiction_Homo sapiens_hsa050300.40448925
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.40324148
141Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38780388
142Hepatitis B_Homo sapiens_hsa051610.37806059
143Thyroid hormone synthesis_Homo sapiens_hsa049180.37706916
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.37650619
145Basal cell carcinoma_Homo sapiens_hsa052170.37429250
146Proteoglycans in cancer_Homo sapiens_hsa052050.36706916
147Steroid biosynthesis_Homo sapiens_hsa001000.36050921
148HIF-1 signaling pathway_Homo sapiens_hsa040660.35945031
149Pentose phosphate pathway_Homo sapiens_hsa000300.35907599
150Glycerolipid metabolism_Homo sapiens_hsa005610.34871211
151Gap junction_Homo sapiens_hsa045400.33474838
152Olfactory transduction_Homo sapiens_hsa047400.29108359
153Amoebiasis_Homo sapiens_hsa051460.28354235
154Wnt signaling pathway_Homo sapiens_hsa043100.28112729
155Colorectal cancer_Homo sapiens_hsa052100.24018383
156Adherens junction_Homo sapiens_hsa045200.23579540
157MicroRNAs in cancer_Homo sapiens_hsa052060.23346868
158Chronic myeloid leukemia_Homo sapiens_hsa052200.23084362
159Sulfur relay system_Homo sapiens_hsa041220.22972845
160Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22242360
161Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.21701970
162Endometrial cancer_Homo sapiens_hsa052130.20371122
163Vitamin digestion and absorption_Homo sapiens_hsa049770.18650033
164Glioma_Homo sapiens_hsa052140.18601282
165Insulin signaling pathway_Homo sapiens_hsa049100.17806127
166ErbB signaling pathway_Homo sapiens_hsa040120.15856213
167AMPK signaling pathway_Homo sapiens_hsa041520.15344063
168Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14834075
169Glutamatergic synapse_Homo sapiens_hsa047240.14467270
170Hedgehog signaling pathway_Homo sapiens_hsa043400.14035869
171Fatty acid elongation_Homo sapiens_hsa000620.13589255
172Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13396295

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