CYP27A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.59105555
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.59105555
3L-phenylalanine metabolic process (GO:0006558)7.22867374
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.22867374
5aromatic amino acid family catabolic process (GO:0009074)6.82348730
6indole-containing compound catabolic process (GO:0042436)6.18537112
7indolalkylamine catabolic process (GO:0046218)6.18537112
8tryptophan catabolic process (GO:0006569)6.18537112
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.03864054
10kynurenine metabolic process (GO:0070189)6.01937896
11* bile acid biosynthetic process (GO:0006699)5.81063551
12tryptophan metabolic process (GO:0006568)5.80625985
13glyoxylate metabolic process (GO:0046487)5.72829169
14alpha-linolenic acid metabolic process (GO:0036109)5.57208971
15urea cycle (GO:0000050)5.54385714
16urea metabolic process (GO:0019627)5.54385714
17complement activation, alternative pathway (GO:0006957)5.44964698
18glycosphingolipid catabolic process (GO:0046479)5.42932342
19regulation of protein activation cascade (GO:2000257)5.34833720
20negative regulation of fibrinolysis (GO:0051918)5.34308186
21oligosaccharide catabolic process (GO:0009313)5.31892455
22high-density lipoprotein particle remodeling (GO:0034375)5.30128573
23sulfur amino acid catabolic process (GO:0000098)5.28012117
24peptidyl-glutamic acid carboxylation (GO:0017187)5.25519322
25protein carboxylation (GO:0018214)5.25519322
26cysteine metabolic process (GO:0006534)5.22414441
27regulation of fibrinolysis (GO:0051917)5.19606878
28nitrogen cycle metabolic process (GO:0071941)5.11356110
29regulation of complement activation (GO:0030449)5.02239364
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.00409087
31serine family amino acid catabolic process (GO:0009071)4.95284604
32* bile acid metabolic process (GO:0008206)4.93606429
33aromatic amino acid family metabolic process (GO:0009072)4.92813816
34glycolipid catabolic process (GO:0019377)4.91196859
35regulation of triglyceride catabolic process (GO:0010896)4.80066317
36homocysteine metabolic process (GO:0050667)4.79297046
37tyrosine metabolic process (GO:0006570)4.74573678
38regulation of cholesterol esterification (GO:0010872)4.63789997
39reverse cholesterol transport (GO:0043691)4.61543858
40alpha-amino acid catabolic process (GO:1901606)4.59492978
41lysine metabolic process (GO:0006553)4.58108762
42lysine catabolic process (GO:0006554)4.58108762
43protein-lipid complex remodeling (GO:0034368)4.54179652
44macromolecular complex remodeling (GO:0034367)4.54179652
45plasma lipoprotein particle remodeling (GO:0034369)4.54179652
46coenzyme catabolic process (GO:0009109)4.53034447
47triglyceride homeostasis (GO:0070328)4.52178990
48acylglycerol homeostasis (GO:0055090)4.52178990
49amino-acid betaine metabolic process (GO:0006577)4.46933222
50indolalkylamine metabolic process (GO:0006586)4.36231579
51phospholipid efflux (GO:0033700)4.35898798
52negative regulation of cholesterol transport (GO:0032375)4.35810124
53negative regulation of sterol transport (GO:0032372)4.35810124
54bile acid and bile salt transport (GO:0015721)4.34555049
55ceramide catabolic process (GO:0046514)4.33421260
56cellular biogenic amine catabolic process (GO:0042402)4.32765889
57amine catabolic process (GO:0009310)4.32765889
58epoxygenase P450 pathway (GO:0019373)4.27917142
59plasma lipoprotein particle clearance (GO:0034381)4.26732240
60cellular ketone body metabolic process (GO:0046950)4.26255083
61cellular amino acid catabolic process (GO:0009063)4.23209463
62glycine metabolic process (GO:0006544)4.21846586
63cellular glucuronidation (GO:0052695)4.20309231
64ethanol oxidation (GO:0006069)4.19843160
65imidazole-containing compound metabolic process (GO:0052803)4.19457233
66glutamate metabolic process (GO:0006536)4.17854272
67benzene-containing compound metabolic process (GO:0042537)4.09497829
68cholesterol efflux (GO:0033344)4.08741941
69serine family amino acid metabolic process (GO:0009069)4.06652815
70cellular modified amino acid catabolic process (GO:0042219)4.06348489
71cellular response to thyroid hormone stimulus (GO:0097067)4.00590931
72dicarboxylic acid biosynthetic process (GO:0043650)3.98982239
73amino sugar catabolic process (GO:0046348)3.97955947
74aldehyde catabolic process (GO:0046185)3.93674101
75arginine metabolic process (GO:0006525)3.90841271
76fibrinolysis (GO:0042730)3.89648703
77regulation of cholesterol storage (GO:0010885)3.88133178
78serine family amino acid biosynthetic process (GO:0009070)3.87577891
79acetyl-CoA metabolic process (GO:0006084)3.87180167
80protein-lipid complex assembly (GO:0065005)3.86676049
81cofactor catabolic process (GO:0051187)3.86042179
82drug catabolic process (GO:0042737)3.84151561
83low-density lipoprotein particle remodeling (GO:0034374)3.83035309
84complement activation, classical pathway (GO:0006958)3.82919818
85plasma lipoprotein particle assembly (GO:0034377)3.82436701
86omega-hydroxylase P450 pathway (GO:0097267)3.81932657
87regulation of bile acid biosynthetic process (GO:0070857)3.79234179
88cytolysis (GO:0019835)3.78768066
89complement activation (GO:0006956)3.77765052
90uronic acid metabolic process (GO:0006063)3.74003706
91glucuronate metabolic process (GO:0019585)3.74003706
92carboxylic acid catabolic process (GO:0046395)3.73228112
93organic acid catabolic process (GO:0016054)3.73228112
94positive regulation of triglyceride lipase activity (GO:0061365)3.72119865
95positive regulation of lipoprotein lipase activity (GO:0051006)3.72119865
96short-chain fatty acid metabolic process (GO:0046459)3.71624074
97protein activation cascade (GO:0072376)3.70650984
98phospholipid homeostasis (GO:0055091)3.70574573
99cholesterol homeostasis (GO:0042632)3.70222549
100blood coagulation, intrinsic pathway (GO:0007597)3.68842086
101ketone body metabolic process (GO:1902224)3.68442182
102negative regulation of lipase activity (GO:0060192)3.67594706
103plasma lipoprotein particle organization (GO:0071827)3.65747634
104very-low-density lipoprotein particle assembly (GO:0034379)3.65279894
105positive regulation of lipid catabolic process (GO:0050996)3.64800849
106sterol homeostasis (GO:0055092)3.63877510
107regulation of cholesterol homeostasis (GO:2000188)3.62943560
108protein-lipid complex subunit organization (GO:0071825)3.56525593
109response to thyroid hormone (GO:0097066)3.54410065
110NAD biosynthetic process (GO:0009435)3.52077777
111nicotinamide nucleotide biosynthetic process (GO:0019359)3.51236977
112pyridine nucleotide biosynthetic process (GO:0019363)3.51236977
113opsonization (GO:0008228)3.50646487
114regulation of mononuclear cell migration (GO:0071675)3.41827251
115detection of molecule of bacterial origin (GO:0032490)3.33891908
116N-acetylneuraminate metabolic process (GO:0006054)3.33834808
117membrane lipid catabolic process (GO:0046466)3.30437031
118regulation of macrophage chemotaxis (GO:0010758)3.28575980
119positive regulation of fatty acid biosynthetic process (GO:0045723)3.28051922
120sphingolipid catabolic process (GO:0030149)3.25154893
121positive regulation of cholesterol efflux (GO:0010875)3.22547555
122regulation of apoptotic cell clearance (GO:2000425)3.20877945
123acute-phase response (GO:0006953)3.19082376
124negative regulation of interleukin-12 production (GO:0032695)3.13847818
125peptide catabolic process (GO:0043171)3.12565372
126positive regulation of cellular amide metabolic process (GO:0034250)3.09986658
127hydrogen peroxide biosynthetic process (GO:0050665)3.05930041
128exogenous drug catabolic process (GO:0042738)3.05214559
129lipoprotein metabolic process (GO:0042157)3.03563495
130detection of external biotic stimulus (GO:0098581)3.01358679
131detection of other organism (GO:0098543)3.01142335
132angiotensin maturation (GO:0002003)3.00574226
133positive regulation of extracellular matrix organization (GO:1903055)2.98422076
134response to peptidoglycan (GO:0032494)2.96905964
135positive regulation of sterol transport (GO:0032373)2.92236388
136positive regulation of cholesterol transport (GO:0032376)2.92236388
137neutrophil activation involved in immune response (GO:0002283)2.91548905
138regulation of superoxide anion generation (GO:0032928)2.90868002
139positive regulation of hemostasis (GO:1900048)2.88076950
140positive regulation of blood coagulation (GO:0030194)2.88076950
141positive regulation of coagulation (GO:0050820)2.87764373
142negative regulation of hemostasis (GO:1900047)2.84870439
143negative regulation of blood coagulation (GO:0030195)2.84870439
144fructose metabolic process (GO:0006000)2.83066956
145cholesterol transport (GO:0030301)2.77561529
146sterol transport (GO:0015918)2.77561529
147negative regulation of lipid transport (GO:0032369)2.74043611
148regulation of cholesterol transport (GO:0032374)2.74017235
149regulation of sterol transport (GO:0032371)2.74017235
150apoptotic cell clearance (GO:0043277)2.72477754
151regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.72454830
152lipoprotein transport (GO:0042953)2.71955076
153positive regulation of monocyte chemotaxis (GO:0090026)2.71874149
154detection of bacterium (GO:0016045)2.70443947
155negative regulation of coagulation (GO:0050819)2.69667674
156positive regulation of leukocyte degranulation (GO:0043302)2.67881509
157macrophage activation involved in immune response (GO:0002281)2.67135204
158reactive oxygen species biosynthetic process (GO:1903409)2.65375641
159positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.62915013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.15644816
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.00101731
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.83926641
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.37081624
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.22627214
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.88702329
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.88211335
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00844555
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.96884472
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.82857053
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.64964399
12* IRF8_27001747_Chip-Seq_BMDM_Mouse3.08331561
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95569968
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68519681
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11018014
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05763759
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00121751
18* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5388986
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98332049
20* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97830902
21VDR_24787735_ChIP-Seq_THP-1_Human1.92181524
22* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81515195
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74354250
24SPI1_23127762_ChIP-Seq_K562_Human1.68663690
25VDR_24763502_ChIP-Seq_THP-1_Human1.62917057
26* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62598119
27CLOCK_20551151_ChIP-Seq_293T_Human1.62465801
28HTT_18923047_ChIP-ChIP_STHdh_Human1.55421475
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55205371
30CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54469747
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53303182
32GATA1_22025678_ChIP-Seq_K562_Human1.52943685
33CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51253824
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46091184
35VDR_21846776_ChIP-Seq_THP-1_Human1.41568321
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39467817
37* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36886332
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35889539
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34279922
40SPI1_23547873_ChIP-Seq_NB4_Human1.31222966
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.28538951
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28428513
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28017116
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24261825
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22972718
46PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21078300
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19377243
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.16821512
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16161595
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15955124
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15546106
52CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14857344
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14536762
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13987570
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13945590
56* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13683875
57* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13143713
58* PU_27001747_Chip-Seq_BMDM_Mouse1.11899192
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09531224
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07293745
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06975181
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.06792962
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04598756
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03969242
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.03784772
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00234063
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00093462
68* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99193412
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96961876
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96828224
71GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94924181
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94106443
73BCOR_27268052_Chip-Seq_Bcells_Human0.94070798
74NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93836446
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93775302
76TCF7_22412390_ChIP-Seq_EML_Mouse0.93254739
77SCL_19346495_ChIP-Seq_HPC-7_Human0.92459205
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90889976
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90200389
80RACK7_27058665_Chip-Seq_MCF-7_Human0.89051919
81RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88315473
82* BCL6_27268052_Chip-Seq_Bcells_Human0.87346393
83* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87019415
84RUNX_20019798_ChIP-Seq_JUKART_Human0.85182035
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84896488
86GATA4_25053715_ChIP-Seq_YYC3_Human0.84366825
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83382039
88MAF_26560356_Chip-Seq_TH1_Human0.83309454
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82191849
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.81683101
91GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81557875
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81478515
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81277787
94KDM2B_26808549_Chip-Seq_K562_Human0.81263805
95TFEB_21752829_ChIP-Seq_HELA_Human0.80699304
96STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80440577
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77444940
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76706122
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76445504
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76445504
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76327904
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75111450
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74852119
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73600331
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72786267
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72255763
107ZNF263_19887448_ChIP-Seq_K562_Human0.71830740
108KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70912902
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70249034
110* RARA_24833708_ChIP-Seq_LIVER_Mouse0.66150767
111EGR1_19032775_ChIP-ChIP_M12_Human0.65080200
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61464851
113CEBPB_22108803_ChIP-Seq_LS180_Human0.61344431
114RARB_24833708_ChIP-Seq_LIVER_Mouse0.60376924
115BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59985578
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59351151
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58514194
118FOXA1_25552417_ChIP-Seq_VCAP_Human0.57505588
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.56772328
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.56375713
121LXR_22292898_ChIP-Seq_THP-1_Human0.53467592
122AR_20517297_ChIP-Seq_VCAP_Human0.52846994
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52794910
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.52470024
125CBP_21632823_ChIP-Seq_H3396_Human0.52406281
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.51974210
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.51710759
128PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50981838
129* MYC_19915707_ChIP-ChIP_AK7_Human0.50899883
130GATA1_19941826_ChIP-Seq_K562_Human0.50139599
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50111172
132* ESET_19884257_ChIP-Seq_ESCs_Mouse0.48322776
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.47165478
134STAT1_17558387_ChIP-Seq_HELA_Human0.47128885
135E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.46858267
136GATA2_19941826_ChIP-Seq_K562_Human0.46536033
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.45973085
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45909031
139TAF2_19829295_ChIP-Seq_ESCs_Human0.44932114
140TAF15_26573619_Chip-Seq_HEK293_Human0.44600473
141* P53_21459846_ChIP-Seq_SAOS-2_Human0.44411667
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43455849
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.43391142
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.42263864
145GATA6_25053715_ChIP-Seq_YYC3_Human0.41215017
146* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40220457
147SOX2_20726797_ChIP-Seq_SW620_Human0.39916967
148* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.39900557
149BCAT_22108803_ChIP-Seq_LS180_Human0.39598358
150* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39441201
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.38012771
152MYC_27129775_Chip-Seq_CORNEA_Mouse0.37725251
153* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37162519
154CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.37028646
155CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36843194
156OCT4_20526341_ChIP-Seq_ESCs_Human0.36722682
157GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.36214004
158FOXH1_21741376_ChIP-Seq_EPCs_Human0.35900131
159NCOR_22424771_ChIP-Seq_293T_Human0.35637842
160STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.35611170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.15923398
2MP0005360_urolithiasis7.46300529
3* MP0005085_abnormal_gallbladder_physiolo6.13286203
4MP0005365_abnormal_bile_salt6.07835246
5MP0008875_abnormal_xenobiotic_pharmacok5.11276553
6MP0003806_abnormal_nucleotide_metabolis4.26861501
7MP0003252_abnormal_bile_duct3.94168459
8MP0010329_abnormal_lipoprotein_level3.53530410
9MP0009840_abnormal_foam_cell3.33988929
10MP0003172_abnormal_lysosome_physiology3.30046566
11MP0005083_abnormal_biliary_tract2.95879047
12MP0003195_calcinosis2.85691147
13MP0005332_abnormal_amino_acid2.77713074
14MP0003303_peritoneal_inflammation2.68332013
15MP0001666_abnormal_nutrient_absorption2.63748894
16MP0003191_abnormal_cellular_cholesterol2.36728384
17MP0002419_abnormal_innate_immunity2.18667213
18MP0000609_abnormal_liver_physiology2.16349135
19* MP0002118_abnormal_lipid_homeostasis2.12537238
20MP0002138_abnormal_hepatobiliary_system2.03830967
21MP0002148_abnormal_hypersensitivity_rea1.90519990
22MP0009785_altered_susceptibility_to1.88906712
23MP0003868_abnormal_feces_composition1.87224770
24* MP0004019_abnormal_vitamin_homeostasis1.85162581
25MP0005319_abnormal_enzyme/_coenzyme1.83311402
26MP0001835_abnormal_antigen_presentation1.74804386
27MP0005025_abnormal_response_to1.71610231
28MP0000343_altered_response_to1.67609036
29MP0001764_abnormal_homeostasis1.63409820
30MP0005387_immune_system_phenotype1.62861724
31MP0001790_abnormal_immune_system1.62861724
32MP0005584_abnormal_enzyme/coenzyme_acti1.61864508
33MP0002998_abnormal_bone_remodeling1.58836137
34MP0005257_abnormal_intraocular_pressure1.57160576
35MP0005451_abnormal_body_composition1.49749368
36MP0001533_abnormal_skeleton_physiology1.46202976
37MP0009697_abnormal_copulation1.44186473
38MP0000685_abnormal_immune_system1.43397209
39MP0005000_abnormal_immune_tolerance1.37864436
40MP0003300_gastrointestinal_ulcer1.37716525
41MP0003011_delayed_dark_adaptation1.36898245
42MP0005671_abnormal_response_to1.35775627
43MP0000920_abnormal_myelination1.32178773
44MP0003656_abnormal_erythrocyte_physiolo1.31246023
45MP0002452_abnormal_antigen_presenting1.28725921
46MP0005167_abnormal_blood-brain_barrier1.28551487
47MP0003186_abnormal_redox_activity1.28088495
48MP0008260_abnormal_autophagy1.27281242
49MP0009643_abnormal_urine_homeostasis1.27067841
50MP0004510_myositis1.25977336
51MP0003183_abnormal_peptide_metabolism1.19599040
52MP0000598_abnormal_liver_morphology1.16160064
53MP0005647_abnormal_sex_gland1.14322949
54MP0000604_amyloidosis1.14171576
55MP0002723_abnormal_immune_serum1.13374748
56MP0000371_diluted_coat_color1.13080303
57MP0003705_abnormal_hypodermis_morpholog1.12105532
58MP0002254_reproductive_system_inflammat1.11196666
59MP0009764_decreased_sensitivity_to1.08451773
60MP0010155_abnormal_intestine_physiology1.06313498
61MP0005310_abnormal_salivary_gland1.05255051
62MP0005670_abnormal_white_adipose1.05079158
63MP0001800_abnormal_humoral_immune1.02634685
64MP0009763_increased_sensitivity_to1.02406120
65MP0005164_abnormal_response_to1.01052852
66MP0000858_altered_metastatic_potential1.00515023
67MP0003879_abnormal_hair_cell0.99602962
68MP0002405_respiratory_system_inflammati0.98094109
69MP0002420_abnormal_adaptive_immunity0.95552008
70MP0001819_abnormal_immune_cell0.94748833
71MP0010368_abnormal_lymphatic_system0.92843624
72MP0008469_abnormal_protein_level0.92704947
73MP0004947_skin_inflammation0.92435536
74MP0005636_abnormal_mineral_homeostasis0.90262903
75MP0006054_spinal_hemorrhage0.88626809
76MP0003690_abnormal_glial_cell0.86336563
77MP0003828_pulmonary_edema0.86166290
78MP0003632_abnormal_nervous_system0.85954382
79MP0006036_abnormal_mitochondrial_physio0.85906576
80* MP0009642_abnormal_blood_homeostasis0.85468609
81MP0009333_abnormal_splenocyte_physiolog0.85385652
82MP0004130_abnormal_muscle_cell0.85228578
83MP0005397_hematopoietic_system_phenotyp0.84492821
84MP0001545_abnormal_hematopoietic_system0.84492821
85MP0002877_abnormal_melanocyte_morpholog0.84209951
86MP0002971_abnormal_brown_adipose0.82993312
87MP0003448_altered_tumor_morphology0.82196665
88MP0005408_hypopigmentation0.81135929
89MP0002876_abnormal_thyroid_physiology0.80618494
90MP0005376_homeostasis/metabolism_phenot0.78923842
91MP0002132_abnormal_respiratory_system0.78031610
92MP0009765_abnormal_xenobiotic_induced0.78015234
93MP0002078_abnormal_glucose_homeostasis0.76445845
94MP0005334_abnormal_fat_pad0.73569976
95MP0005535_abnormal_body_temperature0.72305927
96MP0005084_abnormal_gallbladder_morpholo0.72210439
97MP0003329_amyloid_beta_deposits0.71761983
98MP0003634_abnormal_glial_cell0.69020653
99MP0001661_extended_life_span0.67458686
100MP0005220_abnormal_exocrine_pancreas0.66917372
101MP0005266_abnormal_metabolism0.66274698
102MP0009278_abnormal_bone_marrow0.65642595
103MP0001915_intracranial_hemorrhage0.63480995
104MP0003633_abnormal_nervous_system0.61256966
105MP0001756_abnormal_urination0.58926240
106MP0001851_eye_inflammation0.58876136
107MP0003795_abnormal_bone_structure0.58408839
108MP0000639_abnormal_adrenal_gland0.56534478
109MP0000716_abnormal_immune_system0.56194269
110MP0006035_abnormal_mitochondrial_morpho0.55887227
111MP0005448_abnormal_energy_balance0.54759696
112MP0005464_abnormal_platelet_physiology0.54207327
113MP0002837_dystrophic_cardiac_calcinosis0.53955035
114MP0005666_abnormal_adipose_tissue0.53610283
115MP0004381_abnormal_hair_follicle0.51785699
116MP0003724_increased_susceptibility_to0.50445242
117MP0009053_abnormal_anal_canal0.50291063
118MP0002136_abnormal_kidney_physiology0.49135664
119MP0003436_decreased_susceptibility_to0.47898391
120MP0005058_abnormal_lysosome_morphology0.47773806
121MP0003075_altered_response_to0.47305739
122MP0003638_abnormal_response/metabolism_0.46741767
123MP0006082_CNS_inflammation0.46570740
124MP0008874_decreased_physiological_sensi0.46203006
125MP0008873_increased_physiological_sensi0.45807570
126MP0000579_abnormal_nail_morphology0.44552986
127MP0005395_other_phenotype0.44351108
128MP0005166_decreased_susceptibility_to0.43961658
129MP0002822_catalepsy0.43718225
130MP0009384_cardiac_valve_regurgitation0.43009186
131MP0002928_abnormal_bile_duct0.42819322
132MP0004782_abnormal_surfactant_physiolog0.38240304
133MP0000230_abnormal_systemic_arterial0.37625386
134MP0003953_abnormal_hormone_level0.37378340
135MP0003718_maternal_effect0.37082992
136MP0002796_impaired_skin_barrier0.36611213
137MP0009115_abnormal_fat_cell0.35722806
138MP0001853_heart_inflammation0.35621949
139MP0000249_abnormal_blood_vessel0.34879036
140MP0001243_abnormal_dermal_layer0.33790265
141MP0008872_abnormal_physiological_respon0.33301008
142MP0009672_abnormal_birth_weight0.32946337
143MP0002168_other_aberrant_phenotype0.31331826
144MP0002970_abnormal_white_adipose0.31019866
145MP0001845_abnormal_inflammatory_respons0.30592885
146MP0002090_abnormal_vision0.30375796
147MP0002060_abnormal_skin_morphology0.29774971
148MP0005248_abnormal_Harderian_gland0.29657108
149MP0001881_abnormal_mammary_gland0.27271905
150MP0004883_abnormal_blood_vessel0.26128226
151MP0003453_abnormal_keratinocyte_physiol0.25654922

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)7.63606224
2Abnormality of liposaccharide metabolism (HP:0010968)7.63606224
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.63606224
4Intrahepatic cholestasis (HP:0001406)7.36518259
5Abnormality of aromatic amino acid family metabolism (HP:0004338)7.36395140
6Deep venous thrombosis (HP:0002625)7.23082735
7Abnormality of monocarboxylic acid metabolism (HP:0010996)6.55164045
8Prolonged partial thromboplastin time (HP:0003645)6.45601368
9Hypobetalipoproteinemia (HP:0003563)6.20466230
10* Xanthomatosis (HP:0000991)5.87287343
11Complement deficiency (HP:0004431)5.69375003
12Hyperlipoproteinemia (HP:0010980)5.57636875
13Increased cerebral lipofuscin (HP:0011813)5.00809557
14Vacuolated lymphocytes (HP:0001922)4.76113930
15Joint hemorrhage (HP:0005261)4.68393265
16Hypolipoproteinemia (HP:0010981)4.67879893
17Hyperammonemia (HP:0001987)4.61212394
18Hyperglycinemia (HP:0002154)4.39098996
19Abnormality of the common coagulation pathway (HP:0010990)4.34722892
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.32527906
21Abnormality of macrophages (HP:0004311)4.30152966
22Eczematoid dermatitis (HP:0000976)4.26087829
23Abnormality of methionine metabolism (HP:0010901)4.26033038
24Ketosis (HP:0001946)4.25049296
25Abnormality of sulfur amino acid metabolism (HP:0004339)4.23186463
26Abnormality of complement system (HP:0005339)4.17407447
27Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15716278
28Fat malabsorption (HP:0002630)4.15456013
29Hypoalphalipoproteinemia (HP:0003233)4.14103316
30Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13180562
31Dysostosis multiplex (HP:0000943)4.12308234
32Abnormality of serine family amino acid metabolism (HP:0010894)3.99368775
33Abnormality of glycine metabolism (HP:0010895)3.99368775
34Hyperglycinuria (HP:0003108)3.96250942
35Increased neuronal autofluorescent lipopigment (HP:0002074)3.89372828
36Hypoglycemic coma (HP:0001325)3.74456224
37Neurofibrillary tangles (HP:0002185)3.71963742
38Conjugated hyperbilirubinemia (HP:0002908)3.71355917
39* Epidermoid cyst (HP:0200040)3.71109607
40Loss of speech (HP:0002371)3.70765822
41Abnormality of the intrinsic pathway (HP:0010989)3.69316356
42Abnormality of pyrimidine metabolism (HP:0004353)3.67497909
43Purpura (HP:0000979)3.62260624
44Hypercholesterolemia (HP:0003124)3.59528049
45Abnormality of polysaccharide metabolism (HP:0011012)3.56102558
46Abnormality of glycosaminoglycan metabolism (HP:0004371)3.56102558
47Abnormality of mucopolysaccharide metabolism (HP:0011020)3.56102558
48Urinary glycosaminoglycan excretion (HP:0003541)3.50727209
49Mucopolysacchariduria (HP:0008155)3.50727209
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.47010703
51Recurrent abscess formation (HP:0002722)3.43907323
52Abnormality of fatty-acid metabolism (HP:0004359)3.42323244
53Recurrent bacterial skin infections (HP:0005406)3.32630047
54Hyperbilirubinemia (HP:0002904)3.28119363
55Disinhibition (HP:0000734)3.23927697
56Steatorrhea (HP:0002570)3.18848237
57Systemic lupus erythematosus (HP:0002725)3.06306265
58Abnormality of serum amino acid levels (HP:0003112)3.05068045
59Delayed CNS myelination (HP:0002188)3.05062682
60Ketoacidosis (HP:0001993)3.02360815
61Abnormality of nucleobase metabolism (HP:0010932)3.01603067
62Spontaneous abortion (HP:0005268)2.96837396
63Hepatocellular carcinoma (HP:0001402)2.92486425
64Hypochromic microcytic anemia (HP:0004840)2.77916519
65Metabolic acidosis (HP:0001942)2.76613777
66Cerebral inclusion bodies (HP:0100314)2.72946028
67Abnormality of purine metabolism (HP:0004352)2.68655646
68Vascular calcification (HP:0004934)2.63700469
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62528859
70Dicarboxylic aciduria (HP:0003215)2.62528859
71Axonal loss (HP:0003447)2.60615499
72Mutism (HP:0002300)2.60516566
73Retinal atrophy (HP:0001105)2.60184505
74Lethargy (HP:0001254)2.58342318
75Recurrent gram-negative bacterial infections (HP:0005420)2.58124501
76Mediastinal lymphadenopathy (HP:0100721)2.54744572
77Glomerulonephritis (HP:0000099)2.52928042
78Increased serum ferritin (HP:0003281)2.51065446
79Acanthocytosis (HP:0001927)2.50788197
80Mitral stenosis (HP:0001718)2.48508160
81Amyloidosis (HP:0011034)2.45583969
82Orchitis (HP:0100796)2.45215704
83Gout (HP:0001997)2.44199619
84Cerebral edema (HP:0002181)2.41193123
85Cholecystitis (HP:0001082)2.40047806
86Abnormal gallbladder physiology (HP:0012438)2.40047806
87Spastic diplegia (HP:0001264)2.38414116
88Irritability (HP:0000737)2.36825081
89Autoimmune thrombocytopenia (HP:0001973)2.36240180
90Hypoglycemic seizures (HP:0002173)2.34472009
91Cardiovascular calcification (HP:0011915)2.33668977
92Neonatal onset (HP:0003623)2.32731253
93Metaphyseal irregularity (HP:0003025)2.26823703
94Gingivitis (HP:0000230)2.26357163
95* Myocardial infarction (HP:0001658)2.25573196
96Optic neuritis (HP:0100653)2.24911015
97Retrobulbar optic neuritis (HP:0100654)2.24911015
98Neuronal loss in central nervous system (HP:0002529)2.24768385
99Malnutrition (HP:0004395)2.23207177
100Myositis (HP:0100614)2.23051927
101Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22612590
102Obstructive lung disease (HP:0006536)2.22606180
103Chronic obstructive pulmonary disease (HP:0006510)2.22606180
104Gingival bleeding (HP:0000225)2.22341203
105Nuclear cataract (HP:0100018)2.21478946
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20791412
107Diminished motivation (HP:0000745)2.19190763
108Apathy (HP:0000741)2.19071472
109* Skin nodule (HP:0200036)2.17017250
110Esophageal varix (HP:0002040)2.16997735
111Asymmetric septal hypertrophy (HP:0001670)2.16850107
112Peripheral demyelination (HP:0011096)2.16547552
113Pathologic fracture (HP:0002756)2.16213034
114Hepatosplenomegaly (HP:0001433)2.15864677
115Sensorimotor neuropathy (HP:0007141)2.15761895
116* Abnormal gallbladder morphology (HP:0012437)2.14908435
117Pancreatitis (HP:0001733)2.14146281
118Brushfield spots (HP:0001088)2.12402629
119Progressive neurologic deterioration (HP:0002344)2.10404657
120Enlarged kidneys (HP:0000105)2.08857730
121Vomiting (HP:0002013)2.08651802
122Late onset (HP:0003584)2.07672340
123Hemorrhage of the eye (HP:0011885)2.06598551
124Thrombophlebitis (HP:0004418)2.05596960
125Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.05533051
126Upper motor neuron abnormality (HP:0002127)2.05201781
127Generalized aminoaciduria (HP:0002909)2.03473347
128Opisthotonus (HP:0002179)2.03399271
129* Cholelithiasis (HP:0001081)2.01890233
130Menorrhagia (HP:0000132)2.01623594
131Increased CSF protein (HP:0002922)2.00803324
132Rickets (HP:0002748)1.97324691
133Hypophosphatemic rickets (HP:0004912)1.96720474
134Protuberant abdomen (HP:0001538)1.96346915
135Abnormality of iron homeostasis (HP:0011031)1.94089598
136Hyperinsulinemic hypoglycemia (HP:0000825)1.93432874
137Prolonged neonatal jaundice (HP:0006579)1.93185455
138Hydroxyprolinuria (HP:0003080)1.92795283
139Abnormality of proline metabolism (HP:0010907)1.92795283
140Poikilocytosis (HP:0004447)1.92086645
141Recurrent skin infections (HP:0001581)1.91804689
142Vertebral compression fractures (HP:0002953)1.90333963
143Abnormality of transition element cation homeostasis (HP:0011030)1.89538627
144Abnormal enzyme/coenzyme activity (HP:0012379)1.87450358
145Abnormal cartilage morphology (HP:0002763)1.84928052
146Alkalosis (HP:0001948)1.84685614
147Elevated hepatic transaminases (HP:0002910)1.84661532
148Bone pain (HP:0002653)1.84313550
149Nephritis (HP:0000123)1.82452374
150Renal cortical cysts (HP:0000803)1.79385172
151Pulmonary infiltrates (HP:0002113)1.78193323
152Hypophosphatemia (HP:0002148)1.77400495
153Cardiomegaly (HP:0001640)1.77397776
154* Dementia (HP:0000726)1.76711909
155Abnormality of vitamin metabolism (HP:0100508)1.76710557
156Nausea (HP:0002018)1.76481753
157* Abnormality of the gallbladder (HP:0005264)1.76446622
158J-shaped sella turcica (HP:0002680)1.74412900
159Acute hepatic failure (HP:0006554)1.71726081
160Thoracic kyphosis (HP:0002942)1.70829869
161Pulmonary embolism (HP:0002204)1.70444284
162Global brain atrophy (HP:0002283)1.69427550
163Abnormality of the lumbar spine (HP:0100712)1.68366547
164Gangrene (HP:0100758)1.63416119
165Supranuclear gaze palsy (HP:0000605)1.62389296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.67320908
2FGFR44.41109290
3ERN14.25001585
4SIK14.24634586
5TAOK33.06804369
6BLK3.06356086
7ERBB42.95774152
8ACVR1B2.89131261
9RIPK42.82022719
10INSRR2.78182386
11DDR22.31849049
12PDK22.28410843
13MST1R2.11059573
14GRK72.08897532
15FGR2.08799629
16MAP2K42.07560424
17PRPF4B1.98091023
18TYK21.93086532
19MAPK111.89851862
20PKN21.88822563
21FLT31.86325300
22NME21.83339608
23MATK1.75241925
24PIK3CG1.75080560
25EPHB11.70443569
26TRIB31.68300759
27LATS11.61452691
28FGFR21.60035823
29ZAP701.58793277
30PTK61.46227139
31NEK91.45639418
32TAOK21.39127431
33IRAK41.38710885
34ABL21.36843201
35CDC42BPA1.35260263
36PRKAA21.29783131
37MAP3K11.28674016
38JAK21.27819621
39DAPK21.27755603
40TBK11.27391077
41MAP3K141.27202060
42MAP3K71.26779522
43PINK11.21655489
44JAK11.18114161
45FRK1.14230632
46MAP2K31.12278288
47MAPK151.12208618
48MET1.12100998
49KDR1.09860750
50TAOK11.09610712
51TESK21.05973325
52ERBB21.02051672
53PKN11.00562874
54MAP3K20.97802346
55IRAK30.96979797
56MAPK40.95897219
57GRK60.95294872
58TTN0.90546987
59CAMKK20.88055273
60JAK30.87791458
61CAMK1D0.87634033
62MAPK120.87410807
63KSR20.85347047
64LYN0.84865051
65PRKCZ0.84827601
66MOS0.83889618
67MARK30.83878122
68SYK0.82398215
69CAMK2G0.81869498
70GSK3A0.80861133
71CSK0.80610753
72EPHA30.79723708
73MAP3K30.79526019
74CSF1R0.79399619
75FES0.78921895
76RPS6KA20.78488490
77HCK0.78212304
78TGFBR20.77593687
79TIE10.77504024
80PRKG20.75811914
81MAP3K100.75561125
82PDGFRA0.74029815
83PRKACG0.73054112
84STK38L0.69394770
85PRKAA10.68905961
86IKBKE0.67667612
87MAP3K130.67359198
88DYRK1B0.66630370
89PDPK10.65753412
90TESK10.65604382
91CDK60.64740872
92LCK0.64624243
93RPS6KC10.64450955
94RPS6KL10.64450955
95MAP2K60.63423398
96BMPR20.62672721
97RIPK10.61748290
98PAK40.61648608
99PRKCQ0.61294494
100SGK30.60190119
101TYRO30.59102041
102MAPK70.57481381
103ARAF0.56756151
104CSNK1G10.56215782
105FGFR30.55734216
106MAP3K110.54284588
107ADRBK20.52956069
108OBSCN0.52720290
109PBK0.50185998
110GRK10.49912124
111SGK4940.49454753
112SGK2230.49454753
113PTK20.49435445
114FYN0.48528713
115CAMK1G0.48340182
116TNK20.47979731
117RPS6KA60.47907673
118PIM20.47652328
119MARK20.46434441
120ICK0.42277679
121PDK10.42221334
122IGF1R0.41605002
123PIK3CA0.40805966
124BTK0.37974045
125EGFR0.37030940
126LIMK10.36957644
127CAMKK10.36944339
128IRAK10.36133136
129RET0.35960564
130IRAK20.35821973
131SGK20.35204471
132KIT0.32861352
133MAP2K10.32467668
134CSNK1G30.31948969
135MAP4K10.30180350
136MTOR0.29618286
137MAP3K60.29517961
138CSNK1A1L0.29419875
139CSNK1G20.28773011
140PRKD10.28348719
141ABL10.27947997
142MAP3K50.27519356
143ITK0.26819508
144CAMK40.26062883
145PDK30.25344122
146PDK40.25344122
147MYLK0.24841036
148IKBKB0.24589051

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.40361287
2Other glycan degradation_Homo sapiens_hsa005113.78110865
3Nitrogen metabolism_Homo sapiens_hsa009103.54941066
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35973492
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26088040
6Arginine biosynthesis_Homo sapiens_hsa002203.01234059
7Complement and coagulation cascades_Homo sapiens_hsa046102.74735735
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71607161
9Tryptophan metabolism_Homo sapiens_hsa003802.69498448
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59230921
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52235185
12Fatty acid degradation_Homo sapiens_hsa000712.50491748
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42848750
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21403272
15Butanoate metabolism_Homo sapiens_hsa006502.14348622
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12631157
17Peroxisome_Homo sapiens_hsa041462.11433016
18Propanoate metabolism_Homo sapiens_hsa006401.98728761
19Histidine metabolism_Homo sapiens_hsa003401.95171846
20Chemical carcinogenesis_Homo sapiens_hsa052041.91625318
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.91209830
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89471169
23Fatty acid metabolism_Homo sapiens_hsa012121.85512829
24Caffeine metabolism_Homo sapiens_hsa002321.84875787
25* PPAR signaling pathway_Homo sapiens_hsa033201.82162381
26Staphylococcus aureus infection_Homo sapiens_hsa051501.77738140
27beta-Alanine metabolism_Homo sapiens_hsa004101.71047221
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70993470
29Retinol metabolism_Homo sapiens_hsa008301.70210378
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.68972140
31Rheumatoid arthritis_Homo sapiens_hsa053231.64589886
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63205739
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61468481
34Osteoclast differentiation_Homo sapiens_hsa043801.60811047
35Phenylalanine metabolism_Homo sapiens_hsa003601.55034378
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54593995
37Leishmaniasis_Homo sapiens_hsa051401.53220925
38Selenocompound metabolism_Homo sapiens_hsa004501.52573960
39Fatty acid elongation_Homo sapiens_hsa000621.50594163
40Phagosome_Homo sapiens_hsa041451.50118900
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48133820
42Bile secretion_Homo sapiens_hsa049761.48039978
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44738895
44Tyrosine metabolism_Homo sapiens_hsa003501.43484141
45Sulfur metabolism_Homo sapiens_hsa009201.40241136
46Steroid biosynthesis_Homo sapiens_hsa001001.37926379
47Pyruvate metabolism_Homo sapiens_hsa006201.37056225
48Tuberculosis_Homo sapiens_hsa051521.36125133
49Starch and sucrose metabolism_Homo sapiens_hsa005001.30900767
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.27503343
51ABC transporters_Homo sapiens_hsa020101.21720290
52Allograft rejection_Homo sapiens_hsa053301.20355607
53Folate biosynthesis_Homo sapiens_hsa007901.19873983
54Biosynthesis of amino acids_Homo sapiens_hsa012301.16192369
55Asthma_Homo sapiens_hsa053101.15948533
56Fat digestion and absorption_Homo sapiens_hsa049751.14852219
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13560409
58Carbon metabolism_Homo sapiens_hsa012001.12131628
59Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11710716
60Mineral absorption_Homo sapiens_hsa049781.05538702
61Graft-versus-host disease_Homo sapiens_hsa053321.04340444
62Collecting duct acid secretion_Homo sapiens_hsa049661.02910652
63Vitamin B6 metabolism_Homo sapiens_hsa007501.02048643
64Malaria_Homo sapiens_hsa051441.00972697
65Autoimmune thyroid disease_Homo sapiens_hsa053200.98447238
66Arginine and proline metabolism_Homo sapiens_hsa003300.98247798
67Antigen processing and presentation_Homo sapiens_hsa046120.97619432
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94806030
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.94211681
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.93758100
71Sulfur relay system_Homo sapiens_hsa041220.91822435
72Vitamin digestion and absorption_Homo sapiens_hsa049770.86820740
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86649328
74Sphingolipid metabolism_Homo sapiens_hsa006000.85872076
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82544762
76Lysine degradation_Homo sapiens_hsa003100.79369399
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77880486
78Type I diabetes mellitus_Homo sapiens_hsa049400.73306767
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.72128595
80Legionellosis_Homo sapiens_hsa051340.70886854
81Toxoplasmosis_Homo sapiens_hsa051450.68593226
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68541814
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.68288397
84Glycerolipid metabolism_Homo sapiens_hsa005610.68261700
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67525279
86Glutathione metabolism_Homo sapiens_hsa004800.66480858
87Salmonella infection_Homo sapiens_hsa051320.66171836
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65657016
89TNF signaling pathway_Homo sapiens_hsa046680.65525515
90Vibrio cholerae infection_Homo sapiens_hsa051100.63502622
91One carbon pool by folate_Homo sapiens_hsa006700.63015591
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60044802
93Fatty acid biosynthesis_Homo sapiens_hsa000610.57109092
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55429244
95Pentose phosphate pathway_Homo sapiens_hsa000300.55004951
96Hematopoietic cell lineage_Homo sapiens_hsa046400.53663065
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51173280
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50363130
99B cell receptor signaling pathway_Homo sapiens_hsa046620.50253609
100Chemokine signaling pathway_Homo sapiens_hsa040620.48597223
101* Metabolic pathways_Homo sapiens_hsa011000.45643078
102Influenza A_Homo sapiens_hsa051640.43904566
103Viral myocarditis_Homo sapiens_hsa054160.42883180
104Prion diseases_Homo sapiens_hsa050200.42236194
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40418938
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35807990
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35328948
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31377999
109Linoleic acid metabolism_Homo sapiens_hsa005910.27037112
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.26237222
111Insulin resistance_Homo sapiens_hsa049310.25599153
112Fructose and mannose metabolism_Homo sapiens_hsa000510.22657402
113Galactose metabolism_Homo sapiens_hsa000520.22622904
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.19510895
115Glucagon signaling pathway_Homo sapiens_hsa049220.08699474
116AMPK signaling pathway_Homo sapiens_hsa041520.03904026
117Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2234420
118Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2101854
119Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2054626
120Pertussis_Homo sapiens_hsa05133-0.2040859
121Amoebiasis_Homo sapiens_hsa05146-0.1976404
122Lysosome_Homo sapiens_hsa04142-0.1960832
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1846341
124Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1778820
125Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1673136
126Renin-angiotensin system_Homo sapiens_hsa04614-0.1577945
127African trypanosomiasis_Homo sapiens_hsa05143-0.1485890
128Hepatitis C_Homo sapiens_hsa05160-0.1461795
129Ether lipid metabolism_Homo sapiens_hsa00565-0.1362035
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1290535
131Regulation of autophagy_Homo sapiens_hsa04140-0.1186912
132Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1159763
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1088452
134Insulin signaling pathway_Homo sapiens_hsa04910-0.1007675
135Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0927802
136Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0381402
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0066000

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