ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of growth hormone secretion (GO:0060124)	7.74288361
2	growth hormone secretion (GO:0030252)	6.24876569
3	regulation of growth hormone secretion (GO:0060123)	5.50711278
4	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	5.03596264
5	platelet dense granule organization (GO:0060155)	4.94493328
6	purine deoxyribonucleotide catabolic process (GO:0009155)	4.84651715
7	detection of light stimulus involved in sensory perception (GO:0050962)	4.43513980
8	detection of light stimulus involved in visual perception (GO:0050908)	4.43513980
9	positive regulation of guanylate cyclase activity (GO:0031284)	3.85352758
10	transcription from mitochondrial promoter (GO:0006390)	3.83262016
11	mismatch repair (GO:0006298)	3.78125429
12	acetyl-CoA metabolic process (GO:0006084)	3.64008400
13	response to pheromone (GO:0019236)	3.59767139
14	determination of adult lifespan (GO:0008340)	3.55837264
15	purine deoxyribonucleotide metabolic process (GO:0009151)	3.48089414
16	L-fucose catabolic process (GO:0042355)	3.44993749
17	fucose catabolic process (GO:0019317)	3.44993749
18	L-fucose metabolic process (GO:0042354)	3.44993749
19	regulation of guanylate cyclase activity (GO:0031282)	3.44603380
20	positive regulation of protein homodimerization activity (GO:0090073)	3.42096148
21	aspartate family amino acid catabolic process (GO:0009068)	3.39320305
22	transmission of nerve impulse (GO:0019226)	3.35292268
23	imidazole-containing compound metabolic process (GO:0052803)	3.31498204
24	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.31400363
25	negative regulation of thymocyte apoptotic process (GO:0070244)	3.28848536
26	response to vitamin E (GO:0033197)	3.26410170
27	DNA deamination (GO:0045006)	3.25649975
28	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.25023552
29	negative regulation of telomere maintenance (GO:0032205)	3.23242131
30	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	3.20524541
31	one-carbon compound transport (GO:0019755)	3.16688048
32	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.14029972
33	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.08055171
34	mitochondrial RNA metabolic process (GO:0000959)	3.07184912
35	negative regulation of T cell apoptotic process (GO:0070233)	3.05518563
36	coenzyme catabolic process (GO:0009109)	3.05232988
37	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.03697606
38	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.03040136
39	organic cation transport (GO:0015695)	2.99408225
40	cilium or flagellum-dependent cell motility (GO:0001539)	2.96543870
41	RNA destabilization (GO:0050779)	2.95680269
42	long term synaptic depression (GO:0060292)	2.95640178
43	sperm motility (GO:0030317)	2.93027902
44	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.92488175
45	activation of adenylate cyclase activity (GO:0007190)	2.91737775
46	regulation of RIG-I signaling pathway (GO:0039535)	2.91362441
47	positive regulation of lyase activity (GO:0051349)	2.91350596
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.89799386
49	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.88587440
50	axoneme assembly (GO:0035082)	2.88093610
51	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.87467520
52	inositol phosphate dephosphorylation (GO:0046855)	2.87467520
53	actin nucleation (GO:0045010)	2.86267461
54	negative T cell selection (GO:0043383)	2.86090057
55	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.82078545
56	mitochondrial respiratory chain complex assembly (GO:0033108)	2.81923901
57	negative regulation of phagocytosis (GO:0050765)	2.81035089
58	positive T cell selection (GO:0043368)	2.80531277
59	rhodopsin mediated signaling pathway (GO:0016056)	2.80319865
60	deoxyribonucleotide catabolic process (GO:0009264)	2.78245612
61	positive regulation of multicellular organism growth (GO:0040018)	2.78020104
62	anterograde synaptic vesicle transport (GO:0048490)	2.77531176
63	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.77391973
64	glomerular visceral epithelial cell development (GO:0072015)	2.76389786
65	aerobic respiration (GO:0009060)	2.75700024
66	prostate gland growth (GO:0060736)	2.75566993
67	adenosine metabolic process (GO:0046085)	2.75026446
68	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.73780808
69	nucleotide transmembrane transport (GO:1901679)	2.69960294
70	regulation of lipoprotein particle clearance (GO:0010984)	2.66341275
71	regulation of appetite (GO:0032098)	2.66249727
72	DNA demethylation (GO:0080111)	2.65174297
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.64791839
74	NADH dehydrogenase complex assembly (GO:0010257)	2.64791839
75	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.64791839
76	positive regulation of cyclase activity (GO:0031281)	2.64623800
77	regulation of female receptivity (GO:0045924)	2.64599038
78	purine-containing compound salvage (GO:0043101)	2.62831598
79	cornea development in camera-type eye (GO:0061303)	2.62737208
80	white fat cell differentiation (GO:0050872)	2.60400569
81	adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)	2.56651241
82	regulation of B cell receptor signaling pathway (GO:0050855)	2.55543676
83	natural killer cell differentiation (GO:0001779)	2.54799566
84	positive regulation of glycolytic process (GO:0045821)	2.53066544
85	deoxyribose phosphate catabolic process (GO:0046386)	2.52767820
86	glycerophospholipid catabolic process (GO:0046475)	2.49907346
87	positive regulation of prostaglandin secretion (GO:0032308)	2.48369904
88	negative regulation of B cell apoptotic process (GO:0002903)	2.47652160
89	inositol phosphate catabolic process (GO:0071545)	2.47184270
90	synaptic transmission, dopaminergic (GO:0001963)	2.47175691
91	negative regulation of response to food (GO:0032096)	2.45668039
92	negative regulation of appetite (GO:0032099)	2.45668039
93	regulation of cilium movement (GO:0003352)	2.45390255
94	positive regulation of mitochondrial membrane permeability (GO:0035794)	2.45154245
95	nucleoside diphosphate catabolic process (GO:0009134)	2.43567722
96	glyoxylate metabolic process (GO:0046487)	2.43452732
97	respiratory chain complex IV assembly (GO:0008535)	2.42198381
98	positive regulation of adenylate cyclase activity (GO:0045762)	2.41210480
99	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.40598753
100	mannosylation (GO:0097502)	2.39743319

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.85214859
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.09543810
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02542310
4	TAF15_26573619_Chip-Seq_HEK293_Human	2.71984367
5	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.62796467
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.13946396
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.12500198
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10483082
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.98441117
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91932693
11	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.87610488
12	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.85517436
13	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77341153
14	GBX2_23144817_ChIP-Seq_PC3_Human	1.73541118
15	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.71903031
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.70815556
17	EZH2_22144423_ChIP-Seq_EOC_Human	1.68181911
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.56106337
19	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.56090966
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55387339
21	VDR_22108803_ChIP-Seq_LS180_Human	1.54741525
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53966377
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.53521118
24	P300_19829295_ChIP-Seq_ESCs_Human	1.50630364
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.49409735
26	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.49162565
27	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.46668863
28	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.44598042
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.40433393
30	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.40382451
31	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.35685354
32	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.35532794
33	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.35344832
34	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35330555
35	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35330555
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.33492689
37	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.32218998
38	EWS_26573619_Chip-Seq_HEK293_Human	1.31928055
39	HOXB7_26014856_ChIP-Seq_BT474_Human	1.31197479
40	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.30664439
41	DROSHA_22980978_ChIP-Seq_HELA_Human	1.30559730
42	IGF1R_20145208_ChIP-Seq_DFB_Human	1.25275776
43	OCT4_20526341_ChIP-Seq_ESCs_Human	1.24660520
44	TAF2_19829295_ChIP-Seq_ESCs_Human	1.24036265
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23879911
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22634974
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22634974
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22143028
49	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20217482
50	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.19983607
51	GATA3_26560356_Chip-Seq_TH2_Human	1.17550293
52	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.16590752
53	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.15901492
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15849711
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15657767
56	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.14865562
57	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.14695760
58	NCOR_22424771_ChIP-Seq_293T_Human	1.12672039
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11792319
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11665206
61	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10947138
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10264555
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10138386
64	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.09885723
65	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.08839323
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08072844
67	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.07554935
68	TCF4_23295773_ChIP-Seq_U87_Human	1.06948672
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06940330
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06940330
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06665346
72	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.06659325
73	SPI1_20517297_ChIP-Seq_HL60_Human	1.06129988
74	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.06007613
75	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03186313
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02854130
77	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.02004865
78	AR_25329375_ChIP-Seq_VCAP_Human	1.01316279
79	VDR_23849224_ChIP-Seq_CD4+_Human	1.00404853
80	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99298557
81	RAC3_21632823_ChIP-Seq_H3396_Human	0.98236949
82	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95309242
83	TCF4_22108803_ChIP-Seq_LS180_Human	0.94729958
84	MYC_18940864_ChIP-ChIP_HL60_Human	0.94065283
85	STAT3_23295773_ChIP-Seq_U87_Human	0.93887447
86	PHF8_20622853_ChIP-Seq_HELA_Human	0.93855095
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93494680
88	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92238640
89	ERA_21632823_ChIP-Seq_H3396_Human	0.92121539
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91234596
91	FUS_26573619_Chip-Seq_HEK293_Human	0.90624812
92	RUNX2_22187159_ChIP-Seq_PCA_Human	0.90250535
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.90169194
94	RBPJ_21746931_ChIP-Seq_IB4_Human	0.89823307
95	KDM2B_26808549_Chip-Seq_REH_Human	0.89403545
96	AR_20517297_ChIP-Seq_VCAP_Human	0.88723120
97	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.88615846
98	NFYB_21822215_ChIP-Seq_K562_Human	0.88514272
99	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.88414113
100	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.87933191

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	5.57974397
2	MP0009697_abnormal_copulation	4.27010165
3	MP0005646_abnormal_pituitary_gland	4.21471639
4	MP0002909_abnormal_adrenal_gland	3.52984301
5	MP0002102_abnormal_ear_morphology	3.42378379
6	MP0001501_abnormal_sleep_pattern	3.25419206
7	MP0000566_synostosis	3.19746063
8	MP0001984_abnormal_olfaction	2.97465442
9	MP0005551_abnormal_eye_electrophysiolog	2.57540993
10	MP0008875_abnormal_xenobiotic_pharmacok	2.46769550
11	MP0005647_abnormal_sex_gland	2.43660135
12	MP0008872_abnormal_physiological_respon	2.33962490
13	MP0003011_delayed_dark_adaptation	2.30694788
14	MP0006292_abnormal_olfactory_placode	2.13372962
15	MP0000631_abnormal_neuroendocrine_gland	2.08383279
16	MP0008877_abnormal_DNA_methylation	2.06510058
17	MP0002166_altered_tumor_susceptibility	2.05298399
18	MP0006276_abnormal_autonomic_nervous	1.92000466
19	MP0003959_abnormal_lean_body	1.86151441
20	MP0005167_abnormal_blood-brain_barrier	1.84154868
21	MP0002006_tumorigenesis	1.71245294
22	MP0002933_joint_inflammation	1.68499829
23	MP0003252_abnormal_bile_duct	1.64174074
24	MP0001764_abnormal_homeostasis	1.51849127
25	MP0005671_abnormal_response_to	1.46982798
26	MP0003183_abnormal_peptide_metabolism	1.42183804
27	MP0002009_preneoplasia	1.40924286
28	MP0005266_abnormal_metabolism	1.38580423
29	MP0001293_anophthalmia	1.32802219
30	MP0002736_abnormal_nociception_after	1.29452621
31	MP0008961_abnormal_basal_metabolism	1.28479504
32	MP0001661_extended_life_span	1.25302890
33	MP0001529_abnormal_vocalization	1.25061385
34	MP0005365_abnormal_bile_salt	1.22773925
35	MP0001881_abnormal_mammary_gland	1.22279073
36	MP0005410_abnormal_fertilization	1.20191804
37	MP0003646_muscle_fatigue	1.16620627
38	MP0003698_abnormal_male_reproductive	1.14087548
39	MP0001968_abnormal_touch/_nociception	1.13806445
40	MP0002132_abnormal_respiratory_system	1.11737793
41	MP0005253_abnormal_eye_physiology	1.07550162
42	MP0009764_decreased_sensitivity_to	1.07238528
43	MP0005376_homeostasis/metabolism_phenot	1.04669199
44	MP0005083_abnormal_biliary_tract	1.03372687
45	MP0005464_abnormal_platelet_physiology	1.02123817
46	MP0001502_abnormal_circadian_rhythm	1.01919945
47	MP0003283_abnormal_digestive_organ	1.01237415
48	MP0001835_abnormal_antigen_presentation	1.00902543
49	MP0003195_calcinosis	1.00480544
50	MP0001486_abnormal_startle_reflex	1.00335486
51	MP0002234_abnormal_pharynx_morphology	0.98509064
52	MP0010329_abnormal_lipoprotein_level	0.98275771
53	MP0003136_yellow_coat_color	0.96727344
54	MP0001963_abnormal_hearing_physiology	0.96280988
55	MP0001905_abnormal_dopamine_level	0.96128832
56	MP0009333_abnormal_splenocyte_physiolog	0.95883422
57	MP0008995_early_reproductive_senescence	0.95623271
58	MP0009745_abnormal_behavioral_response	0.95596075
59	MP0001485_abnormal_pinna_reflex	0.93814477
60	MP0000230_abnormal_systemic_arterial	0.93242554
61	MP0002693_abnormal_pancreas_physiology	0.91504246
62	MP0002254_reproductive_system_inflammat	0.89632973
63	MP0000372_irregular_coat_pigmentation	0.87364916
64	MP0005171_absent_coat_pigmentation	0.86383461
65	MP0003121_genomic_imprinting	0.86370091
66	MP0000026_abnormal_inner_ear	0.84926331
67	MP0000003_abnormal_adipose_tissue	0.84016173
68	MP0006035_abnormal_mitochondrial_morpho	0.83641360
69	MP0008057_abnormal_DNA_replication	0.82270245
70	MP0002638_abnormal_pupillary_reflex	0.81643060
71	MP0000383_abnormal_hair_follicle	0.81191212
72	MP0003880_abnormal_central_pattern	0.80822780
73	MP0000639_abnormal_adrenal_gland	0.80082704
74	MP0002572_abnormal_emotion/affect_behav	0.78147925
75	MP0001324_abnormal_eye_pigmentation	0.77985809
76	MP0005085_abnormal_gallbladder_physiolo	0.77788022
77	MP0005377_hearing/vestibular/ear_phenot	0.77560806
78	MP0003878_abnormal_ear_physiology	0.77560806
79	MP0008058_abnormal_DNA_repair	0.77281342
80	MP0000685_abnormal_immune_system	0.76823538
81	MP0005000_abnormal_immune_tolerance	0.75144931
82	MP0003638_abnormal_response/metabolism_	0.74840748
83	MP0005360_urolithiasis	0.74276523
84	MP0002160_abnormal_reproductive_system	0.73228391
85	MP0009115_abnormal_fat_cell	0.72299527
86	MP0004133_heterotaxia	0.71808593
87	MP0002067_abnormal_sensory_capabilities	0.71666169
88	MP0001929_abnormal_gametogenesis	0.71444992
89	MP0002229_neurodegeneration	0.70919790
90	MP0002136_abnormal_kidney_physiology	0.70903877
91	MP0001800_abnormal_humoral_immune	0.70877058
92	MP0002723_abnormal_immune_serum	0.70807995
93	MP0005084_abnormal_gallbladder_morpholo	0.69527641
94	MP0001119_abnormal_female_reproductive	0.68939046
95	MP0002210_abnormal_sex_determination	0.68654147
96	MP0004142_abnormal_muscle_tone	0.67694805
97	MP0006072_abnormal_retinal_apoptosis	0.67691798
98	MP0001756_abnormal_urination	0.66751529
99	MP0000427_abnormal_hair_cycle	0.66550067
100	MP0008874_decreased_physiological_sensi	0.66281113

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agammaglobulinemia (HP:0004432)	5.13361373
2	Pancreatic cysts (HP:0001737)	4.73370118
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.32931357
4	Abnormality of alanine metabolism (HP:0010916)	4.32931357
5	Hyperalaninemia (HP:0003348)	4.32931357
6	True hermaphroditism (HP:0010459)	4.19097970
7	Abnormal number of erythroid precursors (HP:0012131)	3.62925173
8	Cystic liver disease (HP:0006706)	3.56968371
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.56766204
10	Severe visual impairment (HP:0001141)	3.52482696
11	Sensory axonal neuropathy (HP:0003390)	3.51964575
12	Large eyes (HP:0001090)	3.43083469
13	Pancreatic fibrosis (HP:0100732)	3.42231469
14	Tubular atrophy (HP:0000092)	3.36384119
15	Spastic paraparesis (HP:0002313)	3.35652390
16	Attenuation of retinal blood vessels (HP:0007843)	3.29969042
17	Abnormality of the renal cortex (HP:0011035)	3.14217821
18	Tubulointerstitial nephritis (HP:0001970)	3.12485099
19	Abnormality of cells of the erythroid lineage (HP:0012130)	3.05268721
20	Nephronophthisis (HP:0000090)	2.94505725
21	Autoimmune thrombocytopenia (HP:0001973)	2.91646264
22	Abnormality of the renal medulla (HP:0100957)	2.89788095
23	Pigmentary retinal degeneration (HP:0001146)	2.88903592
24	Prostate neoplasm (HP:0100787)	2.88369684
25	Acute necrotizing encephalopathy (HP:0006965)	2.81894778
26	Decreased central vision (HP:0007663)	2.73600929
27	Occipital encephalocele (HP:0002085)	2.64971283
28	Tubulointerstitial abnormality (HP:0001969)	2.64951674
29	Sclerocornea (HP:0000647)	2.62675790
30	Abnormality of midbrain morphology (HP:0002418)	2.59058922
31	Molar tooth sign on MRI (HP:0002419)	2.59058922
32	Mesangial abnormality (HP:0001966)	2.58572105
33	Acute encephalopathy (HP:0006846)	2.56889637
34	Furrowed tongue (HP:0000221)	2.56220361
35	Panhypogammaglobulinemia (HP:0003139)	2.51295676
36	Progressive macrocephaly (HP:0004481)	2.50005134
37	Congenital stationary night blindness (HP:0007642)	2.49971206
38	Aplastic anemia (HP:0001915)	2.48287083
39	Increased corneal curvature (HP:0100692)	2.43450054
40	Keratoconus (HP:0000563)	2.43450054
41	Cerebral hypomyelination (HP:0006808)	2.41354989
42	Absent speech (HP:0001344)	2.37415646
43	Abnormal mitochondria in muscle tissue (HP:0008316)	2.35551714
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.35517119
45	Stage 5 chronic kidney disease (HP:0003774)	2.31632020
46	3-Methylglutaconic aciduria (HP:0003535)	2.30687488
47	Chorioretinal atrophy (HP:0000533)	2.22852895
48	Congenital hepatic fibrosis (HP:0002612)	2.20616722
49	Recurrent cutaneous fungal infections (HP:0011370)	2.17971703
50	Chronic mucocutaneous candidiasis (HP:0002728)	2.17971703
51	Hyperkalemia (HP:0002153)	2.17494428
52	Encephalitis (HP:0002383)	2.15703666
53	Abolished electroretinogram (ERG) (HP:0000550)	2.14628719
54	Palpebral edema (HP:0100540)	2.12866497
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.11767366
56	Renal cortical cysts (HP:0000803)	2.10474858
57	Autoimmune hemolytic anemia (HP:0001890)	2.10122005
58	Mitochondrial inheritance (HP:0001427)	2.09712101
59	Inability to walk (HP:0002540)	2.09613429
60	Optic disc pallor (HP:0000543)	2.09209736
61	Arthropathy (HP:0003040)	2.08929751
62	Retinal atrophy (HP:0001105)	2.08670945
63	Abnormality of B cell number (HP:0010975)	2.07535400
64	Recurrent pneumonia (HP:0006532)	2.07498649
65	Tubulointerstitial fibrosis (HP:0005576)	2.06391617
66	Preaxial hand polydactyly (HP:0001177)	2.05550443
67	Congenital sensorineural hearing impairment (HP:0008527)	2.04189961
68	Abnormal drinking behavior (HP:0030082)	2.03961404
69	Polydipsia (HP:0001959)	2.03961404
70	Recurrent lower respiratory tract infections (HP:0002783)	2.02506903
71	Postaxial foot polydactyly (HP:0001830)	2.01902149
72	Congenital, generalized hypertrichosis (HP:0004540)	2.01556751
73	B lymphocytopenia (HP:0010976)	2.01451271
74	Poor speech (HP:0002465)	2.00857508
75	Anencephaly (HP:0002323)	1.98271464
76	CNS hypomyelination (HP:0003429)	1.98256712
77	Hypoplastic left heart (HP:0004383)	1.92585716
78	Pendular nystagmus (HP:0012043)	1.89858012
79	Clumsiness (HP:0002312)	1.87792821
80	Increased intramyocellular lipid droplets (HP:0012240)	1.87764116
81	Abnormality of serum amino acid levels (HP:0003112)	1.85849156
82	Keratoconjunctivitis sicca (HP:0001097)	1.83407607
83	Increased IgM level (HP:0003496)	1.82061393
84	Facial diplegia (HP:0001349)	1.81682168
85	Chronic sinusitis (HP:0011109)	1.81387139
86	Increased CSF lactate (HP:0002490)	1.80510425
87	Keratoconjunctivitis (HP:0001096)	1.80204407
88	Paraparesis (HP:0002385)	1.79811143
89	Synostosis involving the elbow (HP:0003938)	1.78316955
90	Humeroradial synostosis (HP:0003041)	1.78316955
91	Male pseudohermaphroditism (HP:0000037)	1.78291885
92	Bilateral microphthalmos (HP:0007633)	1.77798705
93	Thyroiditis (HP:0100646)	1.77699555
94	Severe combined immunodeficiency (HP:0004430)	1.76397632
95	High anterior hairline (HP:0009890)	1.75709015
96	Growth hormone deficiency (HP:0000824)	1.75279055
97	Genetic anticipation (HP:0003743)	1.71016655
98	Viral hepatitis (HP:0006562)	1.68655212
99	Ketoacidosis (HP:0001993)	1.65097184
100	Hyperglycinemia (HP:0002154)	1.64470332

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	3.72370389
2	FRK	3.65203025
3	KDR	3.40473824
4	VRK2	3.22565370
5	DYRK3	2.80843497
6	MAPKAPK3	2.74928275
7	DAPK1	2.68904304
8	CDK12	2.63830317
9	TAF1	2.46560590
10	MAPKAPK5	2.28875141
11	ACVR1B	2.16529790
12	BMX	2.16231053
13	ADRBK2	2.10504700
14	EPHA4	1.90835399
15	BMPR1B	1.81012851
16	PTK2B	1.78645009
17	MAP4K1	1.78604934
18	MAP3K4	1.69022766
19	VRK1	1.58339818
20	NME1	1.57465173
21	WNK4	1.54361181
22	BCKDK	1.52094161
23	CDK9	1.50770195
24	PBK	1.49484706
25	TNIK	1.48435428
26	SIK2	1.41791713
27	NUAK1	1.36253710
28	MAPK13	1.25704088
29	FLT3	1.23147552
30	PINK1	1.18087416
31	MAP4K2	1.15521281
32	MET	1.13726105
33	KIT	1.12460692
34	CSNK1A1L	1.12437841
35	SYK	1.12157390
36	LIMK1	1.10825536
37	TESK1	1.10812443
38	MST4	1.10553515
39	CSNK1G3	1.10532895
40	PIM2	1.03715504
41	LRRK2	1.03642699
42	BRD4	1.00954960
43	MAP3K12	1.00144727
44	CSNK1G1	0.96620889
45	DDR2	0.96301917
46	EPHB2	0.95665179
47	CSF1R	0.95468800
48	CDK19	0.95367944
49	TXK	0.90111615
50	CSNK1G2	0.88362854
51	TAOK3	0.88058308
52	MYLK	0.87072238
53	DYRK1B	0.86316252
54	IKBKE	0.85973081
55	DYRK1A	0.84823450
56	SRPK1	0.84305483
57	TYRO3	0.84284278
58	DYRK2	0.83099110
59	WNK3	0.82816415
60	ADRBK1	0.81951397
61	PRKCH	0.79636898
62	TIE1	0.79259979
63	CASK	0.78322019
64	INSRR	0.76172697
65	NEK2	0.73162938
66	TNK2	0.72099382
67	GRK5	0.68678571
68	STK4	0.68201450
69	EIF2AK3	0.67142421
70	WNK1	0.66220582
71	EPHA2	0.65807283
72	TGFBR1	0.61756142
73	RPS6KA5	0.60420691
74	AKT3	0.60419003
75	PRKAA1	0.59893427
76	CHUK	0.59605099
77	PIK3CG	0.58568912
78	TRIM28	0.56997291
79	SMG1	0.54506315
80	CAMKK2	0.51718413
81	PRKCQ	0.51654314
82	IKBKB	0.50960937
83	ARAF	0.49576611
84	RPS6KA4	0.45341274
85	LATS1	0.44999656
86	CAMK1	0.44207045
87	CAMK2G	0.43760977
88	IRAK4	0.42981894
89	LYN	0.42852465
90	MAPKAPK2	0.41170178
91	MAPK11	0.40458203
92	DAPK3	0.38499554
93	PIK3CA	0.36206546
94	TEC	0.35976644
95	MELK	0.35802644
96	PRKAA2	0.34688754
97	ZAK	0.33707502
98	GRK1	0.33342556
99	OXSR1	0.33173509
100	MUSK	0.31839091

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.22160271
2	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	3.62169473
3	Phototransduction_Homo sapiens_hsa04744	3.58729071
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.98049361
5	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.97729643
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.68318146
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.42403716
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.38921227
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.27360305
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.98551748
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.84053125
12	Proteasome_Homo sapiens_hsa03050	1.72797972
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.72689370
14	Regulation of autophagy_Homo sapiens_hsa04140	1.72639494
15	Chemical carcinogenesis_Homo sapiens_hsa05204	1.72352048
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.69919889
17	Butanoate metabolism_Homo sapiens_hsa00650	1.67260927
18	Propanoate metabolism_Homo sapiens_hsa00640	1.59955364
19	Ribosome_Homo sapiens_hsa03010	1.59722673
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.57034826
21	Peroxisome_Homo sapiens_hsa04146	1.54485884
22	Parkinsons disease_Homo sapiens_hsa05012	1.51746226
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.49787705
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.41953760
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.34664684
26	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.29639200
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23458830
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.23182081
29	Homologous recombination_Homo sapiens_hsa03440	1.19650356
30	Histidine metabolism_Homo sapiens_hsa00340	1.19481399
31	Graft-versus-host disease_Homo sapiens_hsa05332	1.16862823
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.16692409
33	Antigen processing and presentation_Homo sapiens_hsa04612	1.12690730
34	Pyruvate metabolism_Homo sapiens_hsa00620	1.12467591
35	Olfactory transduction_Homo sapiens_hsa04740	1.10723218
36	Purine metabolism_Homo sapiens_hsa00230	1.10423176
37	Huntingtons disease_Homo sapiens_hsa05016	1.06508868
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03905210
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02938457
40	Caffeine metabolism_Homo sapiens_hsa00232	0.97443667
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94330633
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.92059726
43	Taste transduction_Homo sapiens_hsa04742	0.91578742
44	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.91074756
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.90259473
46	Sulfur relay system_Homo sapiens_hsa04122	0.89850845
47	Retinol metabolism_Homo sapiens_hsa00830	0.87275649
48	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.87095789
49	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.85202924
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.85015385
51	Allograft rejection_Homo sapiens_hsa05330	0.83978468
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83245230
53	Circadian rhythm_Homo sapiens_hsa04710	0.81742076
54	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.79647486
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79247663
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78149385
57	One carbon pool by folate_Homo sapiens_hsa00670	0.76322500
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75124217
59	RNA degradation_Homo sapiens_hsa03018	0.72732764
60	Melanoma_Homo sapiens_hsa05218	0.72536824
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71114303
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.70944090
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.70154005
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69579571
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68892561
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68761230
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68620638
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67901546
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67601348
70	RNA polymerase_Homo sapiens_hsa03020	0.66518546
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66328230
72	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.66210146
73	Nicotine addiction_Homo sapiens_hsa05033	0.61505049
74	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60110765
75	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59515516
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59002712
77	Alzheimers disease_Homo sapiens_hsa05010	0.57761791
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55624214
79	Asthma_Homo sapiens_hsa05310	0.54465291
80	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.52926638
81	Serotonergic synapse_Homo sapiens_hsa04726	0.51116482
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.50838252
83	Alcoholism_Homo sapiens_hsa05034	0.50515195
84	ABC transporters_Homo sapiens_hsa02010	0.49836393
85	Bile secretion_Homo sapiens_hsa04976	0.47962786
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45562305
87	Salivary secretion_Homo sapiens_hsa04970	0.45552294
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45361229
89	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.42561446
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.42537345
91	Protein export_Homo sapiens_hsa03060	0.42521007
92	Metabolic pathways_Homo sapiens_hsa01100	0.42025023
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40079828
94	Platelet activation_Homo sapiens_hsa04611	0.38969032
95	Base excision repair_Homo sapiens_hsa03410	0.37644083
96	Basal transcription factors_Homo sapiens_hsa03022	0.37402374
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.37399732
98	Measles_Homo sapiens_hsa05162	0.36968529
99	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.34838426
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33322007

CYP2AB1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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