CYP2B7P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.90664825
2exogenous drug catabolic process (GO:0042738)9.67878208
3motile cilium assembly (GO:0044458)9.01938145
4epithelial cilium movement (GO:0003351)8.52476829
5drug catabolic process (GO:0042737)8.38153745
6axoneme assembly (GO:0035082)7.12601797
7primary alcohol catabolic process (GO:0034310)6.90716283
8ethanol metabolic process (GO:0006067)5.97942362
9ethanol oxidation (GO:0006069)5.69165245
10surfactant homeostasis (GO:0043129)5.63285348
11left/right pattern formation (GO:0060972)5.54636210
12regulation of cilium movement (GO:0003352)5.32851425
13epoxygenase P450 pathway (GO:0019373)5.10742201
14negative regulation of fibrinolysis (GO:0051918)4.92606684
15drug metabolic process (GO:0017144)4.84072175
16negative regulation of humoral immune response (GO:0002921)4.83397620
17regulation of fibrinolysis (GO:0051917)4.76371018
18regulation of protein activation cascade (GO:2000257)4.67881723
19left/right axis specification (GO:0070986)4.66237557
20diterpenoid biosynthetic process (GO:0016102)4.62950258
21bile acid biosynthetic process (GO:0006699)4.57767489
22fibrinolysis (GO:0042730)4.56583934
23regulation of complement activation (GO:0030449)4.55086121
24chemical homeostasis within a tissue (GO:0048875)4.48680910
25omega-hydroxylase P450 pathway (GO:0097267)4.47531821
26amino-acid betaine metabolic process (GO:0006577)4.40074372
27cellular glucuronidation (GO:0052695)4.36740670
28oxidative demethylation (GO:0070989)4.36217184
29glyoxylate metabolic process (GO:0046487)4.30800429
30glucuronate metabolic process (GO:0019585)4.20297158
31uronic acid metabolic process (GO:0006063)4.20297158
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.18990566
33L-phenylalanine catabolic process (GO:0006559)4.18990566
34vitamin transmembrane transport (GO:0035461)4.06454556
35phenylpropanoid metabolic process (GO:0009698)4.05060722
36one-carbon compound transport (GO:0019755)4.04594773
37negative regulation of cholesterol transport (GO:0032375)3.95919117
38negative regulation of sterol transport (GO:0032372)3.95919117
39ventricular system development (GO:0021591)3.91092016
40microtubule bundle formation (GO:0001578)3.90453097
41bile acid metabolic process (GO:0008206)3.87945656
42primary alcohol metabolic process (GO:0034308)3.85254153
43negative regulation of protein activation cascade (GO:2000258)3.84529339
44L-phenylalanine metabolic process (GO:0006558)3.82443272
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.82443272
46negative regulation of complement activation (GO:0045916)3.78761313
47protein carboxylation (GO:0018214)3.77122447
48peptidyl-glutamic acid carboxylation (GO:0017187)3.77122447
49retinoic acid metabolic process (GO:0042573)3.76539056
50cilium organization (GO:0044782)3.75866559
51aromatic amino acid family catabolic process (GO:0009074)3.64122714
52intraciliary transport (GO:0042073)3.64091858
53pyrimidine-containing compound transmembrane transport (GO:0072531)3.59452740
54polyketide metabolic process (GO:0030638)3.58632400
55doxorubicin metabolic process (GO:0044598)3.58632400
56daunorubicin metabolic process (GO:0044597)3.58632400
57cilium assembly (GO:0042384)3.55332189
58complement activation, alternative pathway (GO:0006957)3.52437291
59fat-soluble vitamin biosynthetic process (GO:0042362)3.51073555
60negative regulation of B cell mediated immunity (GO:0002713)3.51005110
61negative regulation of immunoglobulin mediated immune response (GO:0002890)3.51005110
62carnitine metabolic process (GO:0009437)3.48350609
63lateral ventricle development (GO:0021670)3.47633707
64xenobiotic metabolic process (GO:0006805)3.42117714
65terpenoid biosynthetic process (GO:0016114)3.41368547
66regulation of microtubule-based movement (GO:0060632)3.33449133
67bile acid and bile salt transport (GO:0015721)3.33043917
68response to xenobiotic stimulus (GO:0009410)3.29353802
69hydrogen peroxide biosynthetic process (GO:0050665)3.23981514
70S-adenosylmethionine metabolic process (GO:0046500)3.21030288
71protein localization to cilium (GO:0061512)3.19459364
72aminoglycoside antibiotic metabolic process (GO:0030647)3.19292357
73negative regulation of blood coagulation (GO:0030195)3.19231510
74negative regulation of hemostasis (GO:1900047)3.19231510
75phospholipid efflux (GO:0033700)3.17990228
76regulation of humoral immune response (GO:0002920)3.17804105
77urea metabolic process (GO:0019627)3.16541868
78blood coagulation, intrinsic pathway (GO:0007597)3.16453013
79indole-containing compound catabolic process (GO:0042436)3.15351290
80indolalkylamine catabolic process (GO:0046218)3.15351290
81tryptophan catabolic process (GO:0006569)3.15351290
82flavonoid metabolic process (GO:0009812)3.14501892
83retinal metabolic process (GO:0042574)3.13794489
84androgen metabolic process (GO:0008209)3.06593999
85regulation of interleukin-5 production (GO:0032674)3.05304903
86aldehyde catabolic process (GO:0046185)3.04251173
87regulation of triglyceride catabolic process (GO:0010896)3.03361639
88alkaloid metabolic process (GO:0009820)3.01663280
89serine family amino acid catabolic process (GO:0009071)2.99948308
90lung epithelium development (GO:0060428)2.93975468
91intestinal cholesterol absorption (GO:0030299)2.93810072
92negative regulation of coagulation (GO:0050819)2.91558274
93retinol metabolic process (GO:0042572)2.90196051
94sodium ion homeostasis (GO:0055078)2.88247817
95nitrogen cycle metabolic process (GO:0071941)2.88135688
96benzene-containing compound metabolic process (GO:0042537)2.84693866
97reactive oxygen species biosynthetic process (GO:1903409)2.84145508
98axonemal dynein complex assembly (GO:0070286)13.0216978
99cilium or flagellum-dependent cell motility (GO:0001539)12.5009433
100cilium movement (GO:0003341)10.1650060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.44939541
2FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.77050171
3EGR1_23403033_ChIP-Seq_LIVER_Mouse2.67514051
4ESR1_20079471_ChIP-ChIP_T-47D_Human2.67397189
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.61479590
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.60693034
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45190506
8DROSHA_22980978_ChIP-Seq_HELA_Human2.40334082
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19901163
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.08603078
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07943583
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.04470191
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.00593124
14VDR_22108803_ChIP-Seq_LS180_Human1.99698575
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.93312612
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86623491
17AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.82069411
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75515590
19AHR_22903824_ChIP-Seq_MCF-7_Human1.69338840
20ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66833173
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.62095106
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61257197
23FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.61099898
24FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54515962
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53571739
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.52729649
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48227213
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47762515
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.46697113
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44720102
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.44296456
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40013134
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38612839
34AR_21572438_ChIP-Seq_LNCaP_Human1.37888174
35GATA4_25053715_ChIP-Seq_YYC3_Human1.37560583
36CDX2_20551321_ChIP-Seq_CACO-2_Human1.37061579
37FOXA1_25552417_ChIP-Seq_VCAP_Human1.36903495
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34797167
39TP63_23658742_ChIP-Seq_EP156T_Human1.27508609
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27170354
41TP53_18474530_ChIP-ChIP_U2OS_Human1.24837180
42BCAT_22108803_ChIP-Seq_LS180_Human1.24108430
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23638573
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20623613
45TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17940285
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17406807
47STAT3_23295773_ChIP-Seq_U87_Human1.16265867
48SOX2_20726797_ChIP-Seq_SW620_Human1.14929346
49ETV1_20927104_ChIP-Seq_GIST48_Human1.14258374
50SMAD4_21799915_ChIP-Seq_A2780_Human1.14135342
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13960399
52CEBPB_22108803_ChIP-Seq_LS180_Human1.12083757
53SMAD3_21741376_ChIP-Seq_HESCs_Human1.11860317
54PHF8_20622853_ChIP-Seq_HELA_Human1.11851053
55CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08644386
56TCF4_22108803_ChIP-Seq_LS180_Human1.08023115
57HNFA_21074721_ChIP-Seq_CACO-2_Human1.06501850
58ER_23166858_ChIP-Seq_MCF-7_Human1.06072648
59PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05518312
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.04488744
61TP53_16413492_ChIP-PET_HCT116_Human1.04423811
62AR_20517297_ChIP-Seq_VCAP_Human1.03689134
63HNF4A_19822575_ChIP-Seq_HepG2_Human1.03657500
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.03181407
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03181407
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02173514
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00659524
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.00644342
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00576410
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00065000
71CDX2_22108803_ChIP-Seq_LS180_Human0.99831932
72SMAD4_21741376_ChIP-Seq_HESCs_Human0.99364624
73FOXO3_23340844_ChIP-Seq_DLD1_Human0.98114008
74NFYA_21822215_ChIP-Seq_K562_Human0.97199063
75FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96995491
76P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96312107
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95957448
78CBP_20019798_ChIP-Seq_JUKART_Human0.95957448
79ZNF274_21170338_ChIP-Seq_K562_Hela0.95447511
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95228571
81GATA3_24758297_ChIP-Seq_MCF-7_Human0.95102387
82PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95093556
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94968610
84TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94532813
85SMRT_27268052_Chip-Seq_Bcells_Human0.94233334
86IGF1R_20145208_ChIP-Seq_DFB_Human0.93316417
87STAT1_20625510_ChIP-Seq_HELA_Human0.93209489
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92644495
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92202796
90RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92104157
91CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92095805
92TCF4_23295773_ChIP-Seq_U87_Human0.91560859
93KLF5_25053715_ChIP-Seq_YYC3_Human0.90640042
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90508888
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89932606
96RBPJ_21746931_ChIP-Seq_IB4_Human0.89482923
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89271820
98CJUN_26792858_Chip-Seq_BT549_Human0.88983066
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88145938
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.87940770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.17849509
2MP0002139_abnormal_hepatobiliary_system7.06570166
3MP0005085_abnormal_gallbladder_physiolo5.11618310
4MP0005365_abnormal_bile_salt4.68044237
5MP0003195_calcinosis4.16039989
6MP0002653_abnormal_ependyma_morphology3.53395178
7MP0004782_abnormal_surfactant_physiolog3.45347653
8MP0005360_urolithiasis3.21518103
9MP0002138_abnormal_hepatobiliary_system3.04808276
10MP0003252_abnormal_bile_duct3.02187202
11MP0004043_abnormal_pH_regulation2.73653339
12MP0002132_abnormal_respiratory_system2.64061869
13MP0001666_abnormal_nutrient_absorption2.31024729
14MP0002876_abnormal_thyroid_physiology2.30923232
15MP0005083_abnormal_biliary_tract2.29504682
16MP0009780_abnormal_chondrocyte_physiolo2.16615601
17MP0001984_abnormal_olfaction1.96626577
18MP0010329_abnormal_lipoprotein_level1.87277579
19MP0004133_heterotaxia1.76117260
20MP0005332_abnormal_amino_acid1.75972958
21MP0002168_other_aberrant_phenotype1.67471432
22MP0003868_abnormal_feces_composition1.56977063
23MP0004019_abnormal_vitamin_homeostasis1.56219986
24MP0009840_abnormal_foam_cell1.53388666
25MP0003656_abnormal_erythrocyte_physiolo1.49305429
26MP0000383_abnormal_hair_follicle1.45791001
27MP0002277_abnormal_respiratory_mucosa1.45554362
28MP0008995_early_reproductive_senescence1.41832069
29MP0002118_abnormal_lipid_homeostasis1.38508518
30MP0009643_abnormal_urine_homeostasis1.36611812
31MP0010368_abnormal_lymphatic_system1.34306357
32MP0002282_abnormal_trachea_morphology1.31379813
33MP0005377_hearing/vestibular/ear_phenot1.26400865
34MP0003878_abnormal_ear_physiology1.26400865
35MP0003191_abnormal_cellular_cholesterol1.23796276
36MP0000566_synostosis1.20403227
37MP0004883_abnormal_blood_vessel1.18540628
38MP0005395_other_phenotype1.16433042
39MP0005164_abnormal_response_to1.15678262
40MP0003806_abnormal_nucleotide_metabolis1.10472475
41MP0005636_abnormal_mineral_homeostasis1.10301297
42MP0000609_abnormal_liver_physiology1.09473716
43MP0010678_abnormal_skin_adnexa1.09100578
44MP0002909_abnormal_adrenal_gland1.08414425
45MP0005408_hypopigmentation1.03982393
46MP0001958_emphysema1.00787772
47MP0005551_abnormal_eye_electrophysiolog1.00478342
48MP0005623_abnormal_meninges_morphology0.98592145
49MP0001764_abnormal_homeostasis0.92173868
50MP0008789_abnormal_olfactory_epithelium0.89604306
51MP0001765_abnormal_ion_homeostasis0.87819639
52MP0003950_abnormal_plasma_membrane0.87805014
53MP0002133_abnormal_respiratory_system0.87000218
54MP0005388_respiratory_system_phenotype0.87000218
55MP0002136_abnormal_kidney_physiology0.86610005
56MP0005646_abnormal_pituitary_gland0.83175116
57MP0005319_abnormal_enzyme/_coenzyme0.79534675
58MP0005165_increased_susceptibility_to0.75242393
59MP0008872_abnormal_physiological_respon0.74727347
60MP0003638_abnormal_response/metabolism_0.72961664
61MP0005253_abnormal_eye_physiology0.71399097
62MP0005376_homeostasis/metabolism_phenot0.71274646
63MP0005220_abnormal_exocrine_pancreas0.66772300
64MP0009642_abnormal_blood_homeostasis0.65118970
65MP0009764_decreased_sensitivity_to0.64744718
66MP0009763_increased_sensitivity_to0.63901783
67MP0000249_abnormal_blood_vessel0.61603711
68MP0009697_abnormal_copulation0.60977962
69MP0005584_abnormal_enzyme/coenzyme_acti0.60718323
70MP0001986_abnormal_taste_sensitivity0.59135375
71MP0008469_abnormal_protein_level0.58806447
72MP0001756_abnormal_urination0.58702620
73MP0002160_abnormal_reproductive_system0.58036091
74MP0008004_abnormal_stomach_pH0.57470842
75MP0003045_fibrosis0.57169835
76MP0010155_abnormal_intestine_physiology0.56889180
77MP0002405_respiratory_system_inflammati0.56172555
78MP0005248_abnormal_Harderian_gland0.54336469
79MP0000681_abnormal_thyroid_gland0.54166823
80MP0001790_abnormal_immune_system0.53945269
81MP0005387_immune_system_phenotype0.53945269
82MP0005647_abnormal_sex_gland0.50045988
83MP0002928_abnormal_bile_duct0.49359861
84MP0002135_abnormal_kidney_morphology0.48406578
85MP0002249_abnormal_larynx_morphology0.48406473
86MP0003011_delayed_dark_adaptation0.47537705
87MP0005023_abnormal_wound_healing0.47340079
88MP0001346_abnormal_lacrimal_gland0.45967178
89MP0003075_altered_response_to0.45422870
90MP0005187_abnormal_penis_morphology0.43920162
91MP0000465_gastrointestinal_hemorrhage0.42826754
92MP0009765_abnormal_xenobiotic_induced0.42622084
93MP0001851_eye_inflammation0.42523656
94MP0003879_abnormal_hair_cell0.42488207
95MP0002229_neurodegeneration0.41759864
96MP0001502_abnormal_circadian_rhythm0.41432333
97MP0003186_abnormal_redox_activity0.41395958
98MP0002295_abnormal_pulmonary_circulatio0.41030822
99MP0005195_abnormal_posterior_eye0.40646492
100MP0009046_muscle_twitch0.40089758

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.88985659
2Abnormal respiratory motile cilium morphology (HP:0005938)9.88985659
3Abnormal ciliary motility (HP:0012262)9.55155215
4Abnormal respiratory motile cilium physiology (HP:0012261)9.48737024
5Rhinitis (HP:0012384)8.53774765
6Chronic bronchitis (HP:0004469)7.04336557
7Bronchiectasis (HP:0002110)6.42991876
8Nasal polyposis (HP:0100582)5.43535834
9Abnormality of the nasal mucosa (HP:0000433)4.64244784
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.50966307
11Bronchitis (HP:0012387)4.17852596
12Recurrent sinusitis (HP:0011108)3.88788620
13Infertility (HP:0000789)3.61402112
14Chronic sinusitis (HP:0011109)3.48916799
15Recurrent otitis media (HP:0000403)3.46766556
16Hyperactive renin-angiotensin system (HP:0000841)3.24995413
17Tubulointerstitial nephritis (HP:0001970)3.07758802
18Deep venous thrombosis (HP:0002625)3.07658263
19Pancreatic fibrosis (HP:0100732)3.03707876
20Occipital encephalocele (HP:0002085)3.02615209
21Chronic hepatic failure (HP:0100626)2.98232298
22True hermaphroditism (HP:0010459)2.90182311
23Interstitial pulmonary disease (HP:0006530)2.88879996
24Complement deficiency (HP:0004431)2.88563702
25Male infertility (HP:0003251)2.87928625
26Pancreatic cysts (HP:0001737)2.71441283
27Nephronophthisis (HP:0000090)2.66089367
28Prolonged partial thromboplastin time (HP:0003645)2.57509557
29Abnormality of midbrain morphology (HP:0002418)2.56559395
30Molar tooth sign on MRI (HP:0002419)2.56559395
31Chronic otitis media (HP:0000389)2.55871200
32Cystic liver disease (HP:0006706)2.51265606
33Decreased circulating renin level (HP:0003351)2.46857605
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.35645365
35Abnormality of the renal medulla (HP:0100957)2.35554969
36Conjugated hyperbilirubinemia (HP:0002908)2.35452541
37Atelectasis (HP:0100750)2.32477277
38Tubulointerstitial abnormality (HP:0001969)2.22908965
39Tubulointerstitial fibrosis (HP:0005576)2.22908750
40Renal salt wasting (HP:0000127)2.22646421
41Tubular atrophy (HP:0000092)2.22220156
42Recurrent bronchitis (HP:0002837)2.20894872
43Hypobetalipoproteinemia (HP:0003563)2.19599515
44Vascular calcification (HP:0004934)2.18322488
45Abnormality of complement system (HP:0005339)2.15449250
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15003424
47Intrahepatic cholestasis (HP:0001406)2.10830831
48Congenital hepatic fibrosis (HP:0002612)2.10181327
49Glomerulonephritis (HP:0000099)2.07032667
50Systemic lupus erythematosus (HP:0002725)2.06833431
51Hyperkalemia (HP:0002153)2.06101792
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.7274645
53Dynein arm defect of respiratory motile cilia (HP:0012255)10.4122982
54Absent/shortened dynein arms (HP:0200106)10.4122982
55Postaxial foot polydactyly (HP:0001830)1.93302875
56Fat malabsorption (HP:0002630)1.89530618
57Cardiovascular calcification (HP:0011915)1.86398360
58Male pseudohermaphroditism (HP:0000037)1.86290531
59Nephritis (HP:0000123)1.84460899
60Steatorrhea (HP:0002570)1.80902608
61Bile duct proliferation (HP:0001408)1.79723140
62Abnormal biliary tract physiology (HP:0012439)1.79723140
63Bifid scrotum (HP:0000048)1.79306732
64Rickets (HP:0002748)1.79254615
65Hyperaldosteronism (HP:0000859)1.75861047
66Abnormality of the renal cortex (HP:0011035)1.74092059
67Decreased central vision (HP:0007663)1.73998816
68Joint hemorrhage (HP:0005261)1.73341889
69Hyperlipoproteinemia (HP:0010980)1.70501894
70Abnormality of renin-angiotensin system (HP:0000847)1.70200229
71Mitral stenosis (HP:0001718)1.68757788
72Xanthomatosis (HP:0000991)1.68696515
73Medial flaring of the eyebrow (HP:0010747)1.68600056
74Abnormality of chloride homeostasis (HP:0011422)1.63301892
75Bell-shaped thorax (HP:0001591)1.58753774
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.55947047
77Stage 5 chronic kidney disease (HP:0003774)1.53760198
78Abnormal rod and cone electroretinograms (HP:0008323)1.52493496
79Alveolar cell carcinoma (HP:0006519)1.52086167
80Tachypnea (HP:0002789)1.51116471
81Nephropathy (HP:0000112)1.50324213
82Anencephaly (HP:0002323)1.47337266
83Abnormality of glutamine family amino acid metabolism (HP:0010902)1.46330129
84Aplasia/Hypoplasia of the spleen (HP:0010451)1.46232881
85Furrowed tongue (HP:0000221)1.46227471
86Asplenia (HP:0001746)1.45124438
87Hypokalemic alkalosis (HP:0001949)1.41900289
88Congenital primary aphakia (HP:0007707)1.41329156
89Gait imbalance (HP:0002141)1.39644965
90Abnormality of vitamin metabolism (HP:0100508)1.38329035
91Respiratory distress (HP:0002098)1.35562432
92Neoplasm of the tracheobronchial system (HP:0100552)1.35311892
93Alkalosis (HP:0001948)1.32427071
94Hypolipoproteinemia (HP:0010981)1.31523561
95Recurrent gram-negative bacterial infections (HP:0005420)1.30531349
96Cone-rod dystrophy (HP:0000548)1.29458244
97Portal hypertension (HP:0001409)1.29104718
98Abnormality of pyrimidine metabolism (HP:0004353)1.25981107
99Hemorrhage of the eye (HP:0011885)1.23640015
100Sclerocornea (HP:0000647)1.23333668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.04379598
2MST44.82038906
3EPHA23.54649979
4FRK2.91847841
5BCR2.23031959
6MAPKAPK32.22363738
7EPHA32.10652776
8MST1R2.01108553
9LATS11.94236437
10NME11.89575401
11STK38L1.77700488
12MAP3K21.75004232
13FER1.45773420
14MAP3K31.44823352
15GRK11.39522808
16NLK1.38729560
17ACVR1B1.36829073
18TBK11.30917444
19INSRR1.23200155
20MAP4K21.21608698
21EPHB11.20941246
22TIE11.15403247
23PTK2B1.13804850
24MAP3K71.13395620
25ADRBK21.11562723
26IRAK11.09479837
27STK381.08446505
28ERBB21.07633649
29TRPM71.00707820
30BMPR1B0.97337946
31LRRK20.94681288
32ZAP700.92356079
33PRKAA20.91713668
34TYK20.91215235
35STK100.90342420
36TLK10.90254856
37TAOK30.88223971
38PINK10.87849056
39STK240.87470403
40MUSK0.85701031
41ERBB30.84482099
42FGFR30.81904118
43PDPK10.77474657
44PRKCI0.76695507
45MET0.76207968
46ADRBK10.74536682
47CSK0.74454828
48RIPK10.73197440
49WNK40.71527745
50MAP2K20.69169112
51STK160.68823377
52TXK0.65713809
53DAPK20.64190247
54MARK20.63634599
55PRKCQ0.62685142
56NEK60.60817107
57ERN10.60468755
58IGF1R0.59824369
59WNK30.57949572
60PRKCE0.54896544
61FGFR40.54713760
62MYLK0.54656791
63TTK0.54473850
64CHUK0.54053922
65NTRK30.53332319
66CAMKK10.53282730
67NEK90.51547206
68CDC42BPA0.50425041
69MAP3K120.49021804
70PRKACA0.47516602
71SGK20.47427521
72HIPK20.46998171
73CAMKK20.46828351
74JAK10.46790476
75BRSK20.46711171
76ABL10.46706012
77MAP2K60.46476205
78OXSR10.45569020
79PRKCA0.45536398
80PRKCZ0.45268562
81RPS6KA20.44080613
82TGFBR20.43025773
83IKBKE0.42657829
84PRKACG0.41373743
85SGK10.40689949
86PRKD10.40261181
87PRKCD0.39071229
88PAK30.38970014
89SGK2230.38601109
90SGK4940.38601109
91MAP3K40.37793138
92GRK70.36530354
93EGFR0.35164452
94EEF2K0.29782239
95MAP2K10.27859079
96STK110.27603238
97MAPK130.27457842
98MAPK110.26956036
99PRKG10.26043438
100GRK60.25490095

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.77130419
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.00915469
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.00757215
4Chemical carcinogenesis_Homo sapiens_hsa052043.71286183
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.55620705
6Retinol metabolism_Homo sapiens_hsa008303.48215700
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17234955
8Phenylalanine metabolism_Homo sapiens_hsa003603.08264773
9Histidine metabolism_Homo sapiens_hsa003402.75583246
10Complement and coagulation cascades_Homo sapiens_hsa046102.74170696
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.70437476
12Tyrosine metabolism_Homo sapiens_hsa003502.46325574
13Linoleic acid metabolism_Homo sapiens_hsa005912.42872952
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38242831
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.33898945
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.31118344
17beta-Alanine metabolism_Homo sapiens_hsa004102.16049026
18Butanoate metabolism_Homo sapiens_hsa006502.14121483
19Fatty acid degradation_Homo sapiens_hsa000712.04903061
20Tryptophan metabolism_Homo sapiens_hsa003802.04638953
21ABC transporters_Homo sapiens_hsa020101.65241342
22Bile secretion_Homo sapiens_hsa049761.63095057
23Peroxisome_Homo sapiens_hsa041461.46994804
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40490455
25Arachidonic acid metabolism_Homo sapiens_hsa005901.38751717
26Arginine biosynthesis_Homo sapiens_hsa002201.33392905
27Starch and sucrose metabolism_Homo sapiens_hsa005001.33165918
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32360797
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.32114620
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29079415
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27065660
32PPAR signaling pathway_Homo sapiens_hsa033201.14041518
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11620816
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07891013
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04510503
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99124430
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94909594
38Staphylococcus aureus infection_Homo sapiens_hsa051500.94786295
39Glutathione metabolism_Homo sapiens_hsa004800.85653220
40Sphingolipid metabolism_Homo sapiens_hsa006000.79931786
41Propanoate metabolism_Homo sapiens_hsa006400.74681433
42Arginine and proline metabolism_Homo sapiens_hsa003300.72986327
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.68102212
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65428755
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61335090
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.61143688
47Fatty acid metabolism_Homo sapiens_hsa012120.60736664
48Pyruvate metabolism_Homo sapiens_hsa006200.58379146
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57887244
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.54209232
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48087041
52Fat digestion and absorption_Homo sapiens_hsa049750.45812136
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45410869
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45175873
55Huntingtons disease_Homo sapiens_hsa050160.42253704
56Vitamin B6 metabolism_Homo sapiens_hsa007500.42154280
57Metabolic pathways_Homo sapiens_hsa011000.41818477
58Ether lipid metabolism_Homo sapiens_hsa005650.41034833
59Circadian rhythm_Homo sapiens_hsa047100.41031893
60Selenocompound metabolism_Homo sapiens_hsa004500.40376555
61Glycerolipid metabolism_Homo sapiens_hsa005610.39407532
62Pertussis_Homo sapiens_hsa051330.37333208
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36024416
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.32916883
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32886594
66Mineral absorption_Homo sapiens_hsa049780.30084574
67Serotonergic synapse_Homo sapiens_hsa047260.29831385
68Tight junction_Homo sapiens_hsa045300.27935636
69Nitrogen metabolism_Homo sapiens_hsa009100.27583461
70Phototransduction_Homo sapiens_hsa047440.26726663
71Ovarian steroidogenesis_Homo sapiens_hsa049130.24985897
72Sulfur metabolism_Homo sapiens_hsa009200.24868430
73Lysosome_Homo sapiens_hsa041420.24200523
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23970115
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22872080
76Steroid biosynthesis_Homo sapiens_hsa001000.22388172
77Lysine degradation_Homo sapiens_hsa003100.21590465
78Vitamin digestion and absorption_Homo sapiens_hsa049770.17234543
79Insulin resistance_Homo sapiens_hsa049310.16584742
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16488084
81Taste transduction_Homo sapiens_hsa047420.16094779
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16055484
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14713258
84Salivary secretion_Homo sapiens_hsa049700.13762860
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12919424
86Fatty acid biosynthesis_Homo sapiens_hsa000610.11885425
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.11140164
88Asthma_Homo sapiens_hsa053100.10034146
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08493015
90Hepatitis C_Homo sapiens_hsa051600.06010268
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.03671928
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.01659394
93Autoimmune thyroid disease_Homo sapiens_hsa053200.01653983
94Allograft rejection_Homo sapiens_hsa053300.01081511
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.01031575
96Collecting duct acid secretion_Homo sapiens_hsa049660.00497790
97Hematopoietic cell lineage_Homo sapiens_hsa046400.00110749
98Biosynthesis of amino acids_Homo sapiens_hsa01230-0.0193769
99Graft-versus-host disease_Homo sapiens_hsa05332-0.0084498
100Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0040381

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