CYP2C8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, alternative pathway (GO:0006957)9.49248291
2* exogenous drug catabolic process (GO:0042738)9.00455401
3* drug catabolic process (GO:0042737)8.84359740
4* epoxygenase P450 pathway (GO:0019373)8.57276742
5* omega-hydroxylase P450 pathway (GO:0097267)8.49976009
6regulation of protein activation cascade (GO:2000257)8.48667696
7regulation of fibrinolysis (GO:0051917)8.18384282
8glyoxylate metabolic process (GO:0046487)8.12291404
9regulation of complement activation (GO:0030449)8.05110320
10L-phenylalanine catabolic process (GO:0006559)7.98130125
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.98130125
12negative regulation of fibrinolysis (GO:0051918)7.64260684
13L-phenylalanine metabolic process (GO:0006558)7.25254388
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25254388
15ethanol oxidation (GO:0006069)6.97905226
16urea metabolic process (GO:0019627)6.97816922
17peptidyl-glutamic acid carboxylation (GO:0017187)6.86557282
18protein carboxylation (GO:0018214)6.86557282
19nitrogen cycle metabolic process (GO:0071941)6.33691722
20fibrinolysis (GO:0042730)6.27176913
21* drug metabolic process (GO:0017144)6.24753932
22blood coagulation, intrinsic pathway (GO:0007597)6.15807504
23bile acid biosynthetic process (GO:0006699)6.07892505
24aromatic amino acid family catabolic process (GO:0009074)5.99799997
25urea cycle (GO:0000050)5.89056935
26serine family amino acid catabolic process (GO:0009071)5.88292601
27cellular glucuronidation (GO:0052695)5.72273024
28imidazole-containing compound metabolic process (GO:0052803)5.66773382
29protein activation cascade (GO:0072376)5.66354290
30ethanol metabolic process (GO:0006067)5.62646003
31opsonization (GO:0008228)5.57784569
32complement activation (GO:0006956)5.50065459
33regulation of triglyceride catabolic process (GO:0010896)5.49649785
34uronic acid metabolic process (GO:0006063)5.43180487
35glucuronate metabolic process (GO:0019585)5.43180487
36complement activation, classical pathway (GO:0006958)5.39332518
37phenylpropanoid metabolic process (GO:0009698)5.39188493
38bile acid metabolic process (GO:0008206)5.37884684
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.37055542
40negative regulation of sterol transport (GO:0032372)5.28097189
41negative regulation of cholesterol transport (GO:0032375)5.28097189
42regulation of plasminogen activation (GO:0010755)5.17639892
43* oxidative demethylation (GO:0070989)5.12468586
44regulation of humoral immune response (GO:0002920)5.12162997
45glycine metabolic process (GO:0006544)5.09770525
46acute-phase response (GO:0006953)4.94912855
47negative regulation of protein activation cascade (GO:2000258)4.91343569
48bile acid and bile salt transport (GO:0015721)4.89837450
49killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.86210875
50disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.86210875
51cytolysis (GO:0019835)4.83017003
52S-adenosylmethionine metabolic process (GO:0046500)4.79452106
53negative regulation of hemostasis (GO:1900047)4.71514135
54negative regulation of blood coagulation (GO:0030195)4.71514135
55tyrosine metabolic process (GO:0006570)4.67889252
56glutamate metabolic process (GO:0006536)4.44028624
57positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.41243409
58triglyceride homeostasis (GO:0070328)4.40622881
59acylglycerol homeostasis (GO:0055090)4.40622881
60positive regulation of lipoprotein lipase activity (GO:0051006)4.33224105
61positive regulation of triglyceride lipase activity (GO:0061365)4.33224105
62negative regulation of coagulation (GO:0050819)4.28707936
63negative regulation of wound healing (GO:0061045)4.26703907
64alkaloid metabolic process (GO:0009820)4.26653711
65indole-containing compound catabolic process (GO:0042436)4.23506550
66indolalkylamine catabolic process (GO:0046218)4.23506550
67tryptophan catabolic process (GO:0006569)4.23506550
68plasma lipoprotein particle remodeling (GO:0034369)4.16735429
69protein-lipid complex remodeling (GO:0034368)4.16735429
70macromolecular complex remodeling (GO:0034367)4.16735429
71alpha-amino acid catabolic process (GO:1901606)4.12011044
72amino-acid betaine metabolic process (GO:0006577)4.08326969
73serine family amino acid metabolic process (GO:0009069)4.05922415
74phospholipid efflux (GO:0033700)4.05158374
75positive regulation of blood coagulation (GO:0030194)4.03931352
76positive regulation of hemostasis (GO:1900048)4.03931352
77arginine metabolic process (GO:0006525)4.01084872
78negative regulation of complement activation (GO:0045916)4.00736943
79cholesterol efflux (GO:0033344)3.98829602
80hormone catabolic process (GO:0042447)3.97467754
81high-density lipoprotein particle remodeling (GO:0034375)3.92493026
82aromatic amino acid family metabolic process (GO:0009072)3.91131654
83flavonoid metabolic process (GO:0009812)3.90522331
84cellular ketone body metabolic process (GO:0046950)3.88676441
85regulation of cholesterol esterification (GO:0010872)3.75590084
86positive regulation of coagulation (GO:0050820)3.71071681
87acute inflammatory response (GO:0002526)3.67429126
88negative regulation of lipase activity (GO:0060192)3.66907766
89reverse cholesterol transport (GO:0043691)3.60162673
90tryptophan metabolic process (GO:0006568)3.59138454
91regulation of acute inflammatory response (GO:0002673)3.58212317
92serine family amino acid biosynthetic process (GO:0009070)3.57211451
93cellular amino acid catabolic process (GO:0009063)3.53348117
94sodium-independent organic anion transport (GO:0043252)3.50165386
95response to mercury ion (GO:0046689)3.50067827
96* xenobiotic metabolic process (GO:0006805)3.47397689
97heme transport (GO:0015886)3.45841918
98intestinal cholesterol absorption (GO:0030299)3.40804765
99ketone body metabolic process (GO:1902224)3.40686955
100regulation of apoptotic cell clearance (GO:2000425)3.39826431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse7.10302552
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.93996690
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.72599407
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.69463394
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.40037484
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.86128820
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.67583964
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.04663752
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83764654
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72527875
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07881888
12HTT_18923047_ChIP-ChIP_STHdh_Human2.06971805
13FOXA2_19822575_ChIP-Seq_HepG2_Human2.01333721
14HNF4A_19822575_ChIP-Seq_HepG2_Human2.00930949
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2572605
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83967039
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66329924
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.32821894
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29534653
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29304493
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24806509
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19212268
23AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15460086
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08439396
25PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05405053
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.01854761
27BCAT_22108803_ChIP-Seq_LS180_Human1.01416540
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97852552
29HNFA_21074721_ChIP-Seq_CACO-2_Human0.95807017
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93874333
31PHF8_20622853_ChIP-Seq_HELA_Human0.93711227
32* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93506631
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93051557
34TRIM28_21343339_ChIP-Seq_HEK293_Human0.92785866
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89654504
36NFE2_27457419_Chip-Seq_LIVER_Mouse0.88737659
37PIAS1_25552417_ChIP-Seq_VCAP_Human0.87746596
38GATA1_22025678_ChIP-Seq_K562_Human0.87320818
39NFYA_21822215_ChIP-Seq_K562_Human0.86175104
40RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85620295
41* CBP_21632823_ChIP-Seq_H3396_Human0.85069806
42GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83676779
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81989599
44IRF1_19129219_ChIP-ChIP_H3396_Human0.80780817
45AR_20517297_ChIP-Seq_VCAP_Human0.80347076
46GATA6_21074721_ChIP-Seq_CACO-2_Human0.79948115
47EZH2_27294783_Chip-Seq_NPCs_Mouse0.79229439
48TP53_18474530_ChIP-ChIP_U2OS_Human0.78777013
49GATA4_25053715_ChIP-Seq_YYC3_Human0.78668542
50KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74830406
51FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74605719
52POU3F2_20337985_ChIP-ChIP_501MEL_Human0.73753024
53ER_23166858_ChIP-Seq_MCF-7_Human0.72877462
54CEBPB_22108803_ChIP-Seq_LS180_Human0.71908846
55ETV2_25802403_ChIP-Seq_MESCs_Mouse0.71506399
56FOXA1_25552417_ChIP-Seq_VCAP_Human0.70019154
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69332845
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69259444
59SOX2_21211035_ChIP-Seq_LN229_Human0.69252415
60CBX2_22325352_ChIP-Seq_293T-Rex_Human0.69216539
61SUZ12_27294783_Chip-Seq_NPCs_Mouse0.65823113
62ETV1_20927104_ChIP-Seq_GIST48_Human0.65299814
63SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.62554400
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.62480576
65NFYB_21822215_ChIP-Seq_K562_Human0.61338804
66CRX_20693478_ChIP-Seq_RETINA_Mouse0.61158733
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60954144
68ERG_20517297_ChIP-Seq_VCAP_Human0.59231717
69RAC3_21632823_ChIP-Seq_H3396_Human0.58575111
70PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.58402445
71MYC_19829295_ChIP-Seq_ESCs_Human0.57593952
72OCT4_18555785_Chip-Seq_ESCs_Mouse0.57046855
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.57028180
74CDX2_22108803_ChIP-Seq_LS180_Human0.56699358
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.55992465
76OCT4_21477851_ChIP-Seq_ESCs_Mouse0.55878692
77CDX2_20551321_ChIP-Seq_CACO-2_Human0.54545918
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54391724
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.54256129
80CBP_20019798_ChIP-Seq_JUKART_Human0.54256129
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.54245356
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.53779199
83SALL4_18804426_ChIP-ChIP_XEN_Mouse0.53131693
84SOX2_27498859_Chip-Seq_STOMACH_Mouse0.52756166
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.52622218
86P53_21459846_ChIP-Seq_SAOS-2_Human0.52473918
87RBPJ_21746931_ChIP-Seq_IB4_Human0.52463791
88RUNX1_27457419_Chip-Seq_LIVER_Mouse0.52073245
89TAF2_19829295_ChIP-Seq_ESCs_Human0.51967091
90SPI1_20517297_ChIP-Seq_HL60_Human0.51557202
91ESRRB_18555785_Chip-Seq_ESCs_Mouse0.51232166
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.51041773
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.51016232
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.50986342
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.50761830
96SMAD1_18555785_Chip-Seq_ESCs_Mouse0.50281371
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.50218589
98NCOR_22424771_ChIP-Seq_293T_Human0.48806625
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.48349889
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.48349889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.73162760
2MP0005085_abnormal_gallbladder_physiolo6.38074495
3MP0005360_urolithiasis6.13538356
4MP0008875_abnormal_xenobiotic_pharmacok6.07651621
5MP0005365_abnormal_bile_salt5.62529867
6MP0003195_calcinosis5.00919546
7MP0002138_abnormal_hepatobiliary_system4.81655275
8MP0003252_abnormal_bile_duct4.30415730
9MP0001666_abnormal_nutrient_absorption3.06872451
10MP0003868_abnormal_feces_composition2.95206496
11MP0010329_abnormal_lipoprotein_level2.85657010
12MP0009697_abnormal_copulation2.67195599
13MP0003191_abnormal_cellular_cholesterol2.60265639
14MP0005332_abnormal_amino_acid2.44627137
15MP0003806_abnormal_nucleotide_metabolis2.31325333
16MP0010368_abnormal_lymphatic_system2.10068056
17MP0009840_abnormal_foam_cell1.86165354
18MP0000609_abnormal_liver_physiology1.85470113
19MP0002876_abnormal_thyroid_physiology1.76726851
20MP0002118_abnormal_lipid_homeostasis1.70332825
21MP0001764_abnormal_homeostasis1.66149807
22MP0005670_abnormal_white_adipose1.42475814
23MP0004019_abnormal_vitamin_homeostasis1.32707689
24MP0001661_extended_life_span1.30559323
25MP0002132_abnormal_respiratory_system1.25654284
26MP0009053_abnormal_anal_canal1.17968259
27MP0005319_abnormal_enzyme/_coenzyme1.10624739
28MP0005408_hypopigmentation1.10435723
29MP0000598_abnormal_liver_morphology1.08377164
30MP0009764_decreased_sensitivity_to1.06337632
31MP0005584_abnormal_enzyme/coenzyme_acti0.97303536
32MP0003656_abnormal_erythrocyte_physiolo0.97043924
33MP0009643_abnormal_urine_homeostasis0.94970375
34MP0009763_increased_sensitivity_to0.91835517
35MP0002282_abnormal_trachea_morphology0.88019124
36MP0005187_abnormal_penis_morphology0.85314013
37MP0005376_homeostasis/metabolism_phenot0.84795875
38MP0002971_abnormal_brown_adipose0.84452036
39MP0009642_abnormal_blood_homeostasis0.84377486
40MP0000604_amyloidosis0.81765067
41MP0003186_abnormal_redox_activity0.79229544
42MP0008872_abnormal_physiological_respon0.78619098
43MP0001915_intracranial_hemorrhage0.77624179
44MP0008469_abnormal_protein_level0.77033242
45MP0003690_abnormal_glial_cell0.72610201
46MP0005636_abnormal_mineral_homeostasis0.72138804
47MP0005395_other_phenotype0.69833958
48MP0005535_abnormal_body_temperature0.68178796
49MP0002168_other_aberrant_phenotype0.67253491
50MP0005266_abnormal_metabolism0.66724475
51MP0005451_abnormal_body_composition0.65119543
52MP0003011_delayed_dark_adaptation0.63337031
53MP0002078_abnormal_glucose_homeostasis0.63246716
54MP0002249_abnormal_larynx_morphology0.62281205
55MP0003879_abnormal_hair_cell0.60464250
56MP0005464_abnormal_platelet_physiology0.60115924
57MP0008874_decreased_physiological_sensi0.57434281
58MP0005334_abnormal_fat_pad0.55376528
59MP0003638_abnormal_response/metabolism_0.51463759
60MP0009785_altered_susceptibility_to0.50533929
61MP0004130_abnormal_muscle_cell0.50340082
62MP0005023_abnormal_wound_healing0.49099856
63MP0009765_abnormal_xenobiotic_induced0.47226095
64MP0005166_decreased_susceptibility_to0.45478240
65MP0000566_synostosis0.45405954
66MP0002332_abnormal_exercise_endurance0.43837216
67MP0000249_abnormal_blood_vessel0.39992452
68MP0005448_abnormal_energy_balance0.37843228
69MP0006036_abnormal_mitochondrial_physio0.37653133
70MP0003075_altered_response_to0.37486226
71MP0000639_abnormal_adrenal_gland0.37443806
72MP0005164_abnormal_response_to0.34825091
73MP0002136_abnormal_kidney_physiology0.34427772
74MP0005220_abnormal_exocrine_pancreas0.34379968
75MP0004883_abnormal_blood_vessel0.33906029
76MP0002928_abnormal_bile_duct0.33143282
77MP0009115_abnormal_fat_cell0.31645494
78MP0004782_abnormal_surfactant_physiolog0.30556567
79MP0003953_abnormal_hormone_level0.30195854
80MP0000467_abnormal_esophagus_morphology0.28844003
81MP0005083_abnormal_biliary_tract0.27451695
82MP0005397_hematopoietic_system_phenotyp0.25470603
83MP0001545_abnormal_hematopoietic_system0.25470603
84MP0005058_abnormal_lysosome_morphology0.24932328
85MP0005647_abnormal_sex_gland0.24237481
86MP0005084_abnormal_gallbladder_morpholo0.24011377
87MP0002128_abnormal_blood_circulation0.22884585
88MP0001944_abnormal_pancreas_morphology0.22693743
89MP0001845_abnormal_inflammatory_respons0.22100139
90MP0001756_abnormal_urination0.21308776
91MP0001851_eye_inflammation0.20749557
92MP0001986_abnormal_taste_sensitivity0.20074394
93MP0003705_abnormal_hypodermis_morpholog0.18795923
94MP0005646_abnormal_pituitary_gland0.18728139
95MP0003633_abnormal_nervous_system0.18583264
96MP0008873_increased_physiological_sensi0.17797176
97MP0005666_abnormal_adipose_tissue0.17476537
98MP0005197_abnormal_uvea_morphology0.17128283
99MP0004142_abnormal_muscle_tone0.16555600
100MP0002135_abnormal_kidney_morphology0.16460892

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.97792544
2Prolonged partial thromboplastin time (HP:0003645)9.27993138
3Abnormality of complement system (HP:0005339)8.68803965
4Abnormality of aromatic amino acid family metabolism (HP:0004338)8.17060520
5Conjugated hyperbilirubinemia (HP:0002908)7.37210529
6Hypobetalipoproteinemia (HP:0003563)7.33620711
7Joint hemorrhage (HP:0005261)6.70235654
8Systemic lupus erythematosus (HP:0002725)6.54349720
9Hyperlipoproteinemia (HP:0010980)5.73888396
10Intrahepatic cholestasis (HP:0001406)5.64911009
11Glomerulonephritis (HP:0000099)5.40403933
12Abnormality of pyrimidine metabolism (HP:0004353)5.20308426
13Recurrent gram-negative bacterial infections (HP:0005420)5.17202551
14Xanthomatosis (HP:0000991)4.85528748
15Spontaneous abortion (HP:0005268)4.67228879
16Abnormality of the common coagulation pathway (HP:0010990)4.59536059
17Hypolipoproteinemia (HP:0010981)4.35665045
18Abnormality of the intrinsic pathway (HP:0010989)4.33783842
19Nephritis (HP:0000123)4.00507653
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.84011015
21Abnormality of methionine metabolism (HP:0010901)3.56597535
22Hypoalphalipoproteinemia (HP:0003233)3.49503329
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.29388004
24Hyperglycinemia (HP:0002154)3.23913983
25Fat malabsorption (HP:0002630)3.21920669
26Hyperammonemia (HP:0001987)3.13567312
27Gingival bleeding (HP:0000225)3.12015660
28Delayed CNS myelination (HP:0002188)2.92228633
29Neonatal hypoglycemia (HP:0001998)2.89647265
30Osteomalacia (HP:0002749)2.88315507
31Generalized aminoaciduria (HP:0002909)2.87881477
32Hypercholesterolemia (HP:0003124)2.85089452
33Abnormality of nucleobase metabolism (HP:0010932)2.84073198
34Abnormality of glycine metabolism (HP:0010895)2.77443647
35Abnormality of serine family amino acid metabolism (HP:0010894)2.77443647
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.74797360
37Hyperbilirubinemia (HP:0002904)2.70541729
38Thrombophlebitis (HP:0004418)2.68816737
39Epidermoid cyst (HP:0200040)2.65599258
40Fair hair (HP:0002286)2.63442252
41Hepatocellular carcinoma (HP:0001402)2.60982680
42Mitral stenosis (HP:0001718)2.52017590
43Abnormality of serum amino acid levels (HP:0003112)2.50176426
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.49047171
45Vascular calcification (HP:0004934)2.48605890
46Rickets (HP:0002748)2.46314895
47Hemorrhage of the eye (HP:0011885)2.42076051
48Pulmonary embolism (HP:0002204)2.39801048
49Purpura (HP:0000979)2.37847209
50Hyperglycinuria (HP:0003108)2.31675738
51Steatorrhea (HP:0002570)2.31500985
52Menorrhagia (HP:0000132)2.29135907
53Cholelithiasis (HP:0001081)2.19174007
54Cardiovascular calcification (HP:0011915)2.19108552
55Reduced antithrombin III activity (HP:0001976)2.15401767
56Metabolic acidosis (HP:0001942)2.12420416
57Abnormal gallbladder morphology (HP:0012437)2.07784988
58Ketosis (HP:0001946)2.03845448
59Hyperphosphaturia (HP:0003109)2.02840702
60Complement deficiency (HP:0004431)10.8288906
61Deep venous thrombosis (HP:0002625)10.0226905
62Elevated alkaline phosphatase (HP:0003155)1.98897293
63Cholecystitis (HP:0001082)1.95696502
64Abnormal gallbladder physiology (HP:0012438)1.95696502
65Joint swelling (HP:0001386)1.95122526
66Abnormality of vitamin metabolism (HP:0100508)1.87236470
67Abnormal enzyme/coenzyme activity (HP:0012379)1.85373366
68Irritability (HP:0000737)1.84226346
69Generalized hypopigmentation of hair (HP:0011358)1.82992018
70Arthropathy (HP:0003040)1.81687474
71Abnormality of alkaline phosphatase activity (HP:0004379)1.81342033
72Increased serum ferritin (HP:0003281)1.80503020
73Abnormality of iron homeostasis (HP:0011031)1.80084092
74Myocardial infarction (HP:0001658)1.78729770
75Abnormality of urine glucose concentration (HP:0011016)1.77386776
76Glycosuria (HP:0003076)1.77386776
77Epistaxis (HP:0000421)1.76999561
78Abnormality of purine metabolism (HP:0004352)1.75798719
79Abnormal biliary tract physiology (HP:0012439)1.72784227
80Bile duct proliferation (HP:0001408)1.72784227
81Gangrene (HP:0100758)1.70807806
82Gout (HP:0001997)1.70160145
83Skin nodule (HP:0200036)1.69191482
84Blue irides (HP:0000635)1.66791856
85Cerebral palsy (HP:0100021)1.66212314
86Abnormality of transition element cation homeostasis (HP:0011030)1.65662229
87Enlarged kidneys (HP:0000105)1.64823052
88Abnormality of the Achilles tendon (HP:0005109)1.64305036
89Hypophosphatemic rickets (HP:0004912)1.61396639
90Abnormal urine phosphate concentration (HP:0012599)1.60962572
91Increased mean platelet volume (HP:0011877)1.56329637
92Lethargy (HP:0001254)1.54246748
93Bifid scrotum (HP:0000048)1.53910298
94Atrioventricular block (HP:0001678)1.53851615
95Poikilocytosis (HP:0004447)1.51109512
96Pancreatitis (HP:0001733)1.50147641
97Abnormal delivery (HP:0001787)1.49618714
98Abnormality of the gallbladder (HP:0005264)1.48081077
99Alkalosis (HP:0001948)1.42280363
100Hypochromic microcytic anemia (HP:0004840)1.41714185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.24754478
2PIK3CG4.72906045
3FGFR43.89987024
4RIPK13.08372952
5TRIB32.75624597
6SIK12.60974478
7BCKDK2.56570580
8TYK22.52586327
9PIK3CA2.45310782
10PRKACG2.41699336
11NTRK32.31084056
12EPHA32.16399183
13MAP2K42.11276767
14PRKAA21.93324207
15TNK21.69060193
16PRKCG1.63320408
17TAOK31.58223983
18PINK11.57975163
19FGFR31.52738643
20MAPK111.50615761
21MAP3K31.44204569
22NLK1.42072219
23IGF1R1.40356665
24PRPF4B1.40086750
25EPHB11.34519741
26JAK11.32830396
27FRK1.30802822
28PDPK11.22155034
29TIE11.20514241
30ERBB21.20256919
31FER1.20181436
32MAP3K21.15696020
33NEK91.13484456
34MST1R1.11279543
35ABL21.09746238
36PRKCZ1.04362051
37WNK31.00319975
38PRKACA1.00135693
39MAP3K11.00110080
40FGFR20.99755155
41PRKG10.99636962
42JAK20.97442438
43BLK0.97162260
44MAP3K60.92091962
45DAPK20.90343242
46PKN20.89186751
47INSRR0.88249278
48EPHA40.88184337
49KDR0.87143855
50STK160.86999285
51PDK10.85298432
52TBK10.85153091
53CAMKK20.84581284
54PRKAA10.83831331
55MYLK0.82196374
56CSF1R0.80629439
57RET0.78194599
58SGK4940.74529932
59SGK2230.74529932
60SGK20.74283475
61AKT30.71341022
62MAPK70.68705964
63MAPK120.67104157
64PRKCA0.65769105
65RPS6KA30.64379116
66CSNK1D0.64354506
67GRK10.60477258
68PDK20.60296489
69PRKCB0.60064089
70PRKACB0.59486577
71CAMKK10.57877477
72SGK30.57556702
73CDK60.57067968
74ARAF0.56058737
75SGK10.55744178
76MUSK0.55406882
77MAPK40.54838959
78KSR20.53526935
79CSNK1E0.51731393
80CDK40.50801608
81MAP3K110.49593963
82MAP3K130.49178409
83MAP3K70.47947788
84PTK60.47792100
85ZAP700.45991253
86KIT0.45066068
87DYRK1B0.43400311
88SRC0.43307683
89GSK3A0.43199775
90IKBKE0.43146884
91CAMK2G0.41854915
92CSNK2A10.40144216
93MET0.37663818
94CSNK2A20.35457043
95CSNK1A10.35266995
96MAPK150.33787828
97DYRK1A0.32913909
98TGFBR20.32725140
99SCYL20.32565216
100MAPK30.32219708

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.45156624
2Complement and coagulation cascades_Homo sapiens_hsa046104.20987255
3Caffeine metabolism_Homo sapiens_hsa002324.16918177
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.88265580
5* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.42347786
6* Retinol metabolism_Homo sapiens_hsa008303.32065815
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24852102
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.89350252
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.80257362
10* Chemical carcinogenesis_Homo sapiens_hsa052042.79274571
11Arginine biosynthesis_Homo sapiens_hsa002202.65202927
12Fatty acid degradation_Homo sapiens_hsa000712.55518990
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.53840927
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51352575
15Phenylalanine metabolism_Homo sapiens_hsa003602.51313165
16Tyrosine metabolism_Homo sapiens_hsa003502.42519787
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.40728769
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.23800288
19Histidine metabolism_Homo sapiens_hsa003402.05552536
20Butanoate metabolism_Homo sapiens_hsa006501.92577206
21Tryptophan metabolism_Homo sapiens_hsa003801.83714857
22Bile secretion_Homo sapiens_hsa049761.77421681
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.67503608
24* Linoleic acid metabolism_Homo sapiens_hsa005911.56271049
25Prion diseases_Homo sapiens_hsa050201.52547979
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51128665
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50408348
28Vitamin B6 metabolism_Homo sapiens_hsa007501.47753780
29Starch and sucrose metabolism_Homo sapiens_hsa005001.47402207
30Staphylococcus aureus infection_Homo sapiens_hsa051501.46987842
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43650362
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.34219097
33PPAR signaling pathway_Homo sapiens_hsa033201.33534159
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.30004351
35beta-Alanine metabolism_Homo sapiens_hsa004101.28118619
36Peroxisome_Homo sapiens_hsa041461.26026543
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20868818
38Biosynthesis of amino acids_Homo sapiens_hsa012301.16392205
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10684358
40Pyruvate metabolism_Homo sapiens_hsa006201.06896461
41* Arachidonic acid metabolism_Homo sapiens_hsa005901.05993592
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94751210
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94162827
44Arginine and proline metabolism_Homo sapiens_hsa003300.90816798
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87264387
46ABC transporters_Homo sapiens_hsa020100.87136061
47Propanoate metabolism_Homo sapiens_hsa006400.85983575
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85580235
49Carbon metabolism_Homo sapiens_hsa012000.84865080
50One carbon pool by folate_Homo sapiens_hsa006700.82568622
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75684973
52Fat digestion and absorption_Homo sapiens_hsa049750.67363472
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.64870541
54Fatty acid metabolism_Homo sapiens_hsa012120.63916356
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58137121
56Sulfur metabolism_Homo sapiens_hsa009200.45270902
57* Metabolic pathways_Homo sapiens_hsa011000.42730446
58Lysine degradation_Homo sapiens_hsa003100.42166844
59Pertussis_Homo sapiens_hsa051330.39096252
60Sulfur relay system_Homo sapiens_hsa041220.38888519
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31125253
62Insulin resistance_Homo sapiens_hsa049310.26969748
63Glycerolipid metabolism_Homo sapiens_hsa005610.24349681
64Systemic lupus erythematosus_Homo sapiens_hsa053220.21970951
65Glucagon signaling pathway_Homo sapiens_hsa049220.21869387
66Pentose phosphate pathway_Homo sapiens_hsa000300.17972089
67Fructose and mannose metabolism_Homo sapiens_hsa000510.16036723
68Fatty acid elongation_Homo sapiens_hsa000620.12538662
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.09949242
70Amoebiasis_Homo sapiens_hsa051460.06125491
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05416827
72Vitamin digestion and absorption_Homo sapiens_hsa049770.04986066
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.04216703
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04203431
75AMPK signaling pathway_Homo sapiens_hsa041520.03996937
76Selenocompound metabolism_Homo sapiens_hsa004500.01470475
77Folate biosynthesis_Homo sapiens_hsa007900.01010733
78Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2857297
79GABAergic synapse_Homo sapiens_hsa04727-0.2840632
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2461169
81Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2452706
82Type II diabetes mellitus_Homo sapiens_hsa04930-0.2369470
83Sphingolipid metabolism_Homo sapiens_hsa00600-0.2263549
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.2199956
85Circadian rhythm_Homo sapiens_hsa04710-0.2094949
86Ovarian steroidogenesis_Homo sapiens_hsa04913-0.2094079
87Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1865707
88Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1638735
89Insulin signaling pathway_Homo sapiens_hsa04910-0.1403817
90African trypanosomiasis_Homo sapiens_hsa05143-0.1323604
91Nitrogen metabolism_Homo sapiens_hsa00910-0.1270273
92Steroid biosynthesis_Homo sapiens_hsa00100-0.0906392
93Other glycan degradation_Homo sapiens_hsa00511-0.0883136
94Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0666846
95* Serotonergic synapse_Homo sapiens_hsa04726-0.0636588
96Mineral absorption_Homo sapiens_hsa04978-0.0537706
97Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0358298
98Galactose metabolism_Homo sapiens_hsa00052-0.0184798
99Renin-angiotensin system_Homo sapiens_hsa04614-0.0170088
100Glutathione metabolism_Homo sapiens_hsa00480-0.0163321

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