CYP2C9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* exogenous drug catabolic process (GO:0042738)9.53819717
2* drug catabolic process (GO:0042737)9.02154053
3complement activation, alternative pathway (GO:0006957)8.37283148
4regulation of fibrinolysis (GO:0051917)8.10370903
5* epoxygenase P450 pathway (GO:0019373)7.95976755
6negative regulation of fibrinolysis (GO:0051918)7.95696640
7glyoxylate metabolic process (GO:0046487)7.90459524
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.74263840
9L-phenylalanine catabolic process (GO:0006559)7.74263840
10regulation of protein activation cascade (GO:2000257)7.71806436
11* omega-hydroxylase P450 pathway (GO:0097267)7.50335331
12regulation of complement activation (GO:0030449)7.24904625
13L-phenylalanine metabolic process (GO:0006558)7.09566343
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.09566343
15cellular glucuronidation (GO:0052695)6.98816602
16glucuronate metabolic process (GO:0019585)6.64644708
17uronic acid metabolic process (GO:0006063)6.64644708
18ethanol oxidation (GO:0006069)6.58296615
19fibrinolysis (GO:0042730)6.48519673
20* drug metabolic process (GO:0017144)6.27963986
21bile acid biosynthetic process (GO:0006699)6.24190775
22peptidyl-glutamic acid carboxylation (GO:0017187)6.14517577
23protein carboxylation (GO:0018214)6.14517577
24aromatic amino acid family catabolic process (GO:0009074)5.87607863
25blood coagulation, intrinsic pathway (GO:0007597)5.81280533
26* urea metabolic process (GO:0019627)5.76459264
27urea cycle (GO:0000050)5.76459264
28bile acid metabolic process (GO:0008206)5.68753151
29regulation of triglyceride catabolic process (GO:0010896)5.53782717
30phenylpropanoid metabolic process (GO:0009698)5.46097829
31serine family amino acid catabolic process (GO:0009071)5.45906050
32negative regulation of sterol transport (GO:0032372)5.39835130
33negative regulation of cholesterol transport (GO:0032375)5.39835130
34bile acid and bile salt transport (GO:0015721)5.30530803
35ethanol metabolic process (GO:0006067)5.28038601
36* oxidative demethylation (GO:0070989)5.22417862
37* nitrogen cycle metabolic process (GO:0071941)5.19084158
38protein activation cascade (GO:0072376)5.06189642
39glycine metabolic process (GO:0006544)5.01188040
40regulation of plasminogen activation (GO:0010755)4.96486754
41negative regulation of hemostasis (GO:1900047)4.87165708
42negative regulation of blood coagulation (GO:0030195)4.87165708
43S-adenosylmethionine metabolic process (GO:0046500)4.86810939
44triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.84325603
45complement activation (GO:0006956)4.80845901
46complement activation, classical pathway (GO:0006958)4.71799022
47alkaloid metabolic process (GO:0009820)4.71752031
48amino-acid betaine metabolic process (GO:0006577)4.61216678
49regulation of humoral immune response (GO:0002920)4.58388027
50imidazole-containing compound metabolic process (GO:0052803)4.56065939
51acute-phase response (GO:0006953)4.55841066
52negative regulation of protein activation cascade (GO:2000258)4.53057030
53triglyceride homeostasis (GO:0070328)4.49777737
54acylglycerol homeostasis (GO:0055090)4.49777737
55tyrosine metabolic process (GO:0006570)4.48995755
56negative regulation of coagulation (GO:0050819)4.43246154
57negative regulation of wound healing (GO:0061045)4.40622440
58hormone catabolic process (GO:0042447)4.38415583
59opsonization (GO:0008228)4.32529515
60fat-soluble vitamin biosynthetic process (GO:0042362)4.26888689
61flavonoid metabolic process (GO:0009812)4.26085617
62phospholipid efflux (GO:0033700)4.25547749
63indole-containing compound catabolic process (GO:0042436)4.21691440
64indolalkylamine catabolic process (GO:0046218)4.21691440
65tryptophan catabolic process (GO:0006569)4.21691440
66cytolysis (GO:0019835)4.19264242
67killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.19262087
68disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.19262087
69positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.18376305
70positive regulation of lipoprotein lipase activity (GO:0051006)4.15618292
71positive regulation of triglyceride lipase activity (GO:0061365)4.15618292
72arginine metabolic process (GO:0006525)4.10301785
73plasma lipoprotein particle remodeling (GO:0034369)4.02623817
74protein-lipid complex remodeling (GO:0034368)4.02623817
75macromolecular complex remodeling (GO:0034367)4.02623817
76positive regulation of blood coagulation (GO:0030194)4.01308073
77positive regulation of hemostasis (GO:1900048)4.01308073
78serine family amino acid metabolic process (GO:0009069)3.98397353
79high-density lipoprotein particle remodeling (GO:0034375)3.97403425
80cholesterol efflux (GO:0033344)3.95851038
81daunorubicin metabolic process (GO:0044597)3.95352457
82polyketide metabolic process (GO:0030638)3.95352457
83doxorubicin metabolic process (GO:0044598)3.95352457
84heme transport (GO:0015886)3.92083061
85negative regulation of lipase activity (GO:0060192)3.89280654
86alpha-amino acid catabolic process (GO:1901606)3.88971329
87aromatic amino acid family metabolic process (GO:0009072)3.85434615
88intestinal cholesterol absorption (GO:0030299)3.83962421
89glutamate metabolic process (GO:0006536)3.83228243
90regulation of cholesterol esterification (GO:0010872)3.76256570
91response to mercury ion (GO:0046689)3.72574526
92positive regulation of coagulation (GO:0050820)3.70012048
93* xenobiotic metabolic process (GO:0006805)3.67100192
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.67082032
95negative regulation of complement activation (GO:0045916)3.62868154
96steroid catabolic process (GO:0006706)3.57364429
97cellular ketone body metabolic process (GO:0046950)3.56642650
98reverse cholesterol transport (GO:0043691)3.55362494
99sodium-independent organic anion transport (GO:0043252)3.54725341
100tryptophan metabolic process (GO:0006568)3.53746090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse6.96476291
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.73502730
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.64990533
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.58063574
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.08533299
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.63597987
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.18450398
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.14901133
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.90620004
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21428242
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10813660
12HNF4A_19822575_ChIP-Seq_HepG2_Human2.09514544
13FOXA2_19822575_ChIP-Seq_HepG2_Human2.03253927
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02436174
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8778367
16HTT_18923047_ChIP-ChIP_STHdh_Human1.85496859
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.50849020
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48857314
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36937548
20AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29397613
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29193608
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15879535
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15310097
24BCAT_22108803_ChIP-Seq_LS180_Human1.05992495
25PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03961120
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.03226337
27GATA4_25053715_ChIP-Seq_YYC3_Human1.00538038
28CDX2_20551321_ChIP-Seq_CACO-2_Human0.98776444
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97803356
30IRF8_22096565_ChIP-ChIP_GC-B_Human0.97765548
31CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96148690
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95849798
33NFE2_27457419_Chip-Seq_LIVER_Mouse0.94996701
34* HNFA_21074721_ChIP-Seq_CACO-2_Human0.93422766
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93207819
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92574817
37PIAS1_25552417_ChIP-Seq_VCAP_Human0.92493838
38IRF1_19129219_ChIP-ChIP_H3396_Human0.91726418
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91452635
40* CBP_21632823_ChIP-Seq_H3396_Human0.89224293
41ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89138607
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88878357
43* PHF8_20622853_ChIP-Seq_HELA_Human0.87929608
44RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87374679
45FOXA1_25552417_ChIP-Seq_VCAP_Human0.87205121
46FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86456910
47POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85764665
48AR_20517297_ChIP-Seq_VCAP_Human0.84456894
49EZH2_27294783_Chip-Seq_NPCs_Mouse0.83727441
50GATA1_22025678_ChIP-Seq_K562_Human0.83117818
51IGF1R_20145208_ChIP-Seq_DFB_Human0.83045160
52GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82529061
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82003981
54ER_23166858_ChIP-Seq_MCF-7_Human0.81102553
55CEBPB_22108803_ChIP-Seq_LS180_Human0.81006516
56* NFYA_21822215_ChIP-Seq_K562_Human0.80309726
57KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78738065
58GATA6_21074721_ChIP-Seq_CACO-2_Human0.76215238
59SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74225021
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72924985
61SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72845157
62GATA6_25053715_ChIP-Seq_YYC3_Human0.72277242
63CBX2_22325352_ChIP-Seq_293T-Rex_Human0.70386699
64SOX2_21211035_ChIP-Seq_LN229_Human0.70236881
65SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.69746960
66* TP53_18474530_ChIP-ChIP_U2OS_Human0.69682096
67CRX_20693478_ChIP-Seq_RETINA_Mouse0.67954239
68CDX2_22108803_ChIP-Seq_LS180_Human0.67952076
69ETV2_25802403_ChIP-Seq_MESCs_Mouse0.67792214
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67582543
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67208697
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.66976934
73ETV1_20927104_ChIP-Seq_GIST48_Human0.66357314
74NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66094524
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66094524
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.66047006
77KLF5_20875108_ChIP-Seq_MESCs_Mouse0.64709084
78PCGF2_27294783_Chip-Seq_NPCs_Mouse0.64427077
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.63432430
80OCT4_21477851_ChIP-Seq_ESCs_Mouse0.62128663
81SOX2_20726797_ChIP-Seq_SW620_Human0.61925036
82P53_21459846_ChIP-Seq_SAOS-2_Human0.60626369
83CBP_20019798_ChIP-Seq_JUKART_Human0.59479123
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.59479123
85TCF4_18268006_ChIP-ChIP_LS174T_Human0.59358054
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.59320102
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.59281298
88OCT4_18555785_Chip-Seq_ESCs_Mouse0.59108930
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.58650445
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.58164780
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.56943819
92* NFYB_21822215_ChIP-Seq_K562_Human0.56361449
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.55896144
94ERG_20517297_ChIP-Seq_VCAP_Human0.55891072
95RUNX1_27457419_Chip-Seq_LIVER_Mouse0.55824606
96SMAD1_18555785_Chip-Seq_ESCs_Mouse0.55809762
97ESR2_21235772_ChIP-Seq_MCF-7_Human0.55725002
98RAC3_21632823_ChIP-Seq_H3396_Human0.55289124
99ESRRB_18555785_Chip-Seq_ESCs_Mouse0.55153960
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.55060873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005085_abnormal_gallbladder_physiolo6.48399347
2MP0005360_urolithiasis6.13126548
3MP0005365_abnormal_bile_salt5.96666000
4MP0008875_abnormal_xenobiotic_pharmacok5.65142673
5MP0003195_calcinosis4.76258915
6MP0002138_abnormal_hepatobiliary_system4.58114994
7MP0003252_abnormal_bile_duct4.44676007
8MP0001666_abnormal_nutrient_absorption3.44954232
9MP0003868_abnormal_feces_composition3.35117957
10MP0010329_abnormal_lipoprotein_level2.77176908
11MP0009697_abnormal_copulation2.71518562
12MP0005332_abnormal_amino_acid2.36279212
13MP0003806_abnormal_nucleotide_metabolis2.33458637
14MP0009840_abnormal_foam_cell2.24625921
15MP0003191_abnormal_cellular_cholesterol2.20146734
16MP0002139_abnormal_hepatobiliary_system10.0025658
17MP0002876_abnormal_thyroid_physiology1.97977156
18MP0000609_abnormal_liver_physiology1.86657966
19MP0002118_abnormal_lipid_homeostasis1.70881163
20MP0001764_abnormal_homeostasis1.66831054
21MP0010368_abnormal_lymphatic_system1.52235946
22MP0004019_abnormal_vitamin_homeostasis1.40586313
23MP0005670_abnormal_white_adipose1.26984174
24MP0005408_hypopigmentation1.16726214
25MP0005319_abnormal_enzyme/_coenzyme1.15510271
26MP0009053_abnormal_anal_canal1.12344342
27MP0001661_extended_life_span1.12126776
28MP0005584_abnormal_enzyme/coenzyme_acti1.05370554
29MP0009643_abnormal_urine_homeostasis1.02273466
30MP0000598_abnormal_liver_morphology1.02144200
31MP0003656_abnormal_erythrocyte_physiolo1.00234144
32MP0002132_abnormal_respiratory_system0.99451506
33MP0009764_decreased_sensitivity_to0.92374136
34MP0009763_increased_sensitivity_to0.85175312
35MP0000604_amyloidosis0.84514843
36MP0009642_abnormal_blood_homeostasis0.83601297
37MP0005376_homeostasis/metabolism_phenot0.81514928
38MP0008469_abnormal_protein_level0.79950993
39MP0002971_abnormal_brown_adipose0.78434065
40MP0005636_abnormal_mineral_homeostasis0.77921059
41MP0003186_abnormal_redox_activity0.76304691
42MP0008872_abnormal_physiological_respon0.74857924
43MP0003011_delayed_dark_adaptation0.73728740
44MP0005451_abnormal_body_composition0.73471355
45MP0005395_other_phenotype0.73364383
46MP0005187_abnormal_penis_morphology0.73135415
47MP0005535_abnormal_body_temperature0.69096232
48MP0001915_intracranial_hemorrhage0.69056842
49MP0003879_abnormal_hair_cell0.66294452
50MP0002282_abnormal_trachea_morphology0.63884019
51MP0005266_abnormal_metabolism0.61681592
52MP0003690_abnormal_glial_cell0.61199038
53MP0005464_abnormal_platelet_physiology0.60262411
54MP0002168_other_aberrant_phenotype0.59355782
55MP0003638_abnormal_response/metabolism_0.58398701
56MP0002078_abnormal_glucose_homeostasis0.58056306
57MP0008874_decreased_physiological_sensi0.52235651
58MP0005334_abnormal_fat_pad0.51865979
59MP0002249_abnormal_larynx_morphology0.49473860
60MP0005023_abnormal_wound_healing0.48508302
61MP0009785_altered_susceptibility_to0.48004943
62MP0006036_abnormal_mitochondrial_physio0.44569564
63MP0009765_abnormal_xenobiotic_induced0.41728479
64MP0000249_abnormal_blood_vessel0.39809902
65MP0004130_abnormal_muscle_cell0.37620983
66MP0005166_decreased_susceptibility_to0.37563942
67MP0005448_abnormal_energy_balance0.37432060
68MP0002136_abnormal_kidney_physiology0.37192264
69MP0003718_maternal_effect0.36902661
70MP0005164_abnormal_response_to0.32559750
71MP0005647_abnormal_sex_gland0.31209458
72MP0004883_abnormal_blood_vessel0.29947156
73MP0000467_abnormal_esophagus_morphology0.28302673
74MP0009115_abnormal_fat_cell0.28301854
75MP0005220_abnormal_exocrine_pancreas0.28055782
76MP0002928_abnormal_bile_duct0.27649131
77MP0003953_abnormal_hormone_level0.27380158
78MP0002332_abnormal_exercise_endurance0.27230898
79MP0004782_abnormal_surfactant_physiolog0.26944971
80MP0005058_abnormal_lysosome_morphology0.25581640
81MP0003075_altered_response_to0.25513732
82MP0001756_abnormal_urination0.25210472
83MP0003959_abnormal_lean_body0.25134434
84MP0001845_abnormal_inflammatory_respons0.24804842
85MP0008873_increased_physiological_sensi0.22567528
86MP0004142_abnormal_muscle_tone0.21681483
87MP0005084_abnormal_gallbladder_morpholo0.21034469
88MP0001851_eye_inflammation0.20776246
89MP0002970_abnormal_white_adipose0.17471955
90MP0000639_abnormal_adrenal_gland0.16997048
91MP0001881_abnormal_mammary_gland0.16727553
92MP0000920_abnormal_myelination0.16146073
93MP0001986_abnormal_taste_sensitivity0.15911117
94MP0005197_abnormal_uvea_morphology0.15388458
95MP0005397_hematopoietic_system_phenotyp0.15368703
96MP0001545_abnormal_hematopoietic_system0.15368703
97MP0005083_abnormal_biliary_tract0.15359527
98MP0003632_abnormal_nervous_system0.14830873
99MP0002135_abnormal_kidney_morphology0.14299493
100MP0003633_abnormal_nervous_system0.14008063

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)9.66460842
2Deep venous thrombosis (HP:0002625)9.58565419
3Prolonged partial thromboplastin time (HP:0003645)8.67841953
4Abnormality of aromatic amino acid family metabolism (HP:0004338)8.02203657
5Hypobetalipoproteinemia (HP:0003563)7.92934387
6Abnormality of complement system (HP:0005339)7.83236307
7Conjugated hyperbilirubinemia (HP:0002908)7.44627848
8Systemic lupus erythematosus (HP:0002725)6.17107647
9Joint hemorrhage (HP:0005261)5.92185179
10Intrahepatic cholestasis (HP:0001406)5.62137433
11Hyperlipoproteinemia (HP:0010980)5.55901123
12Glomerulonephritis (HP:0000099)5.27652325
13Abnormality of the common coagulation pathway (HP:0010990)4.85823312
14Abnormality of pyrimidine metabolism (HP:0004353)4.85284627
15Xanthomatosis (HP:0000991)4.76884394
16Spontaneous abortion (HP:0005268)4.62421945
17Hypolipoproteinemia (HP:0010981)4.50318167
18Recurrent gram-negative bacterial infections (HP:0005420)4.42605448
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.04062652
20Abnormality of the intrinsic pathway (HP:0010989)3.97053564
21Nephritis (HP:0000123)3.94710481
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.93558705
23Fat malabsorption (HP:0002630)3.83422874
24Hyperglycinemia (HP:0002154)3.36860608
25Hyperammonemia (HP:0001987)3.33537149
26Generalized aminoaciduria (HP:0002909)3.29654387
27Abnormality of methionine metabolism (HP:0010901)3.16857317
28Gingival bleeding (HP:0000225)3.12016112
29Abnormality of serine family amino acid metabolism (HP:0010894)3.00957549
30Abnormality of glycine metabolism (HP:0010895)3.00957549
31Steatorrhea (HP:0002570)2.97746952
32Rickets (HP:0002748)2.97730712
33Hypoalphalipoproteinemia (HP:0003233)2.95409804
34Delayed CNS myelination (HP:0002188)2.87232783
35Hypercholesterolemia (HP:0003124)2.81315381
36Osteomalacia (HP:0002749)2.79450992
37Hyperglycinuria (HP:0003108)2.77804858
38Abnormality of nucleobase metabolism (HP:0010932)2.76651497
39Hyperbilirubinemia (HP:0002904)2.75560601
40Vascular calcification (HP:0004934)2.74438747
41Mitral stenosis (HP:0001718)2.73808465
42Epidermoid cyst (HP:0200040)2.72724285
43Hemorrhage of the eye (HP:0011885)2.69386894
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.68910291
45Abnormality of serum amino acid levels (HP:0003112)2.63026597
46Thrombophlebitis (HP:0004418)2.57632054
47Fair hair (HP:0002286)2.55107996
48Hepatocellular carcinoma (HP:0001402)2.51554438
49Cardiovascular calcification (HP:0011915)2.42189427
50Purpura (HP:0000979)2.37289145
51Neonatal hypoglycemia (HP:0001998)2.34368593
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.33246844
53Abnormality of vitamin metabolism (HP:0100508)2.32944903
54Pulmonary embolism (HP:0002204)2.28261606
55Reduced antithrombin III activity (HP:0001976)2.28084032
56Hyperphosphaturia (HP:0003109)2.25697308
57Abnormality of urine glucose concentration (HP:0011016)2.22509941
58Glycosuria (HP:0003076)2.22509941
59Metabolic acidosis (HP:0001942)2.21253360
60Cholelithiasis (HP:0001081)2.11280762
61Menorrhagia (HP:0000132)2.09185327
62Elevated alkaline phosphatase (HP:0003155)2.04678437
63Ketosis (HP:0001946)2.02487529
64Abnormal gallbladder morphology (HP:0012437)2.01317805
65Irritability (HP:0000737)2.00304025
66Abnormality of monocarboxylic acid metabolism (HP:0010996)10.2321065
67Joint swelling (HP:0001386)1.98873592
68Hydroxyprolinuria (HP:0003080)1.95779701
69Abnormality of proline metabolism (HP:0010907)1.95779701
70Abnormal gallbladder physiology (HP:0012438)1.94299111
71Cholecystitis (HP:0001082)1.94299111
72Arthropathy (HP:0003040)1.93291186
73Abnormal enzyme/coenzyme activity (HP:0012379)1.92850836
74Abnormality of alkaline phosphatase activity (HP:0004379)1.87102286
75Bifid scrotum (HP:0000048)1.86912745
76Hypophosphatemic rickets (HP:0004912)1.85456544
77Poikilocytosis (HP:0004447)1.84560057
78Abnormality of iron homeostasis (HP:0011031)1.83259276
79Hypochromic microcytic anemia (HP:0004840)1.82020633
80Abnormal urine phosphate concentration (HP:0012599)1.81824817
81Abnormality of purine metabolism (HP:0004352)1.81027980
82Abnormality of the Achilles tendon (HP:0005109)1.79514167
83Generalized hypopigmentation of hair (HP:0011358)1.77772575
84Myocardial infarction (HP:0001658)1.77676447
85Increased serum ferritin (HP:0003281)1.75748664
86Increased mean platelet volume (HP:0011877)1.75133176
87Cerebral palsy (HP:0100021)1.73673501
88Bile duct proliferation (HP:0001408)1.73359793
89Abnormal biliary tract physiology (HP:0012439)1.73359793
90Abnormality of transition element cation homeostasis (HP:0011030)1.71178479
91Gangrene (HP:0100758)1.66134685
92Lethargy (HP:0001254)1.65453118
93Epistaxis (HP:0000421)1.65214227
94Alkalosis (HP:0001948)1.61569723
95Enlarged kidneys (HP:0000105)1.59671807
96Abnormal platelet volume (HP:0011876)1.57450408
97Skin nodule (HP:0200036)1.56643088
98Pancreatitis (HP:0001733)1.55717012
99Proximal tubulopathy (HP:0000114)1.55295652
100Gout (HP:0001997)1.53527834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.78098481
2PIK3CG4.40098212
3FGFR43.25079306
4RIPK12.92983543
5FRK2.81344258
6TYK22.64096074
7EPHA32.44678446
8PIK3CA2.43641600
9PRKACG2.32418349
10NTRK32.19466052
11MST1R2.19431928
12BCKDK2.12174400
13PRKAA21.90300467
14SIK11.87050170
15MAP3K31.68221561
16FER1.66991365
17MAPK111.66854474
18MAP2K41.66152625
19ACVR1B1.61422508
20TAOK31.60322201
21FGFR31.59201008
22TNK21.56922877
23PRKCG1.54020571
24IGF1R1.43156927
25TRIB31.40324382
26MAP3K121.40287750
27PINK11.39277294
28TBK11.38215831
29NEK91.34569791
30ABL21.33092615
31JAK11.29738375
32MAP3K21.29473397
33EPHA41.27471718
34NLK1.27196341
35PRPF4B1.26209475
36MYLK1.21252146
37PDPK11.17722800
38CAMKK21.16632965
39INSRR1.13496235
40PRKCZ1.11431997
41ERBB21.09854059
42PRKG11.02909654
43AKT31.02892033
44LMTK21.01913490
45JAK21.00155369
46PRKACA0.94288710
47PRKAA10.94069044
48DAPK20.93627207
49MET0.92220958
50EPHB10.90915008
51WNK30.90468301
52PDK10.86867478
53GRK10.84338592
54IRAK30.83538658
55MAP4K20.83276931
56BCR0.79876765
57MAP3K10.77260485
58PRKCA0.73412384
59RET0.69405254
60PRKCB0.67793210
61CSF1R0.66773822
62CSNK1D0.66267353
63PDK20.66008769
64TIE10.64320045
65PRKG20.59592135
66CDK60.57829438
67KDR0.57443614
68MAP3K60.56531914
69ZAP700.56301763
70RPS6KA30.53295871
71CASK0.52768488
72ERBB40.52619580
73PRKACB0.50848781
74SRC0.49547536
75PRKCE0.49476283
76MAPK70.49214351
77MAP3K50.47817491
78CSNK1E0.46189793
79MAPKAPK30.45680953
80PAK30.44999868
81MAPK40.41838696
82CAMK2G0.40574130
83MUSK0.40387538
84TGFBR20.40176932
85ICK0.39723948
86PKN20.39194127
87SGK10.38679080
88CSNK1A10.38409564
89MAP3K70.38271082
90SCYL20.37372502
91MAP3K110.37340320
92GSK3A0.36483274
93PTK60.36233687
94SGK20.36021648
95DYRK1B0.35059363
96STK380.34458894
97SGK2230.33497215
98SGK4940.33497215
99SGK30.32637787
100BLK0.32611893

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.59126718
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.03122846
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.96360128
4Complement and coagulation cascades_Homo sapiens_hsa046103.72762151
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.65901269
6* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.41915939
7* Retinol metabolism_Homo sapiens_hsa008303.38068731
8* Chemical carcinogenesis_Homo sapiens_hsa052042.90199112
9* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.87653621
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.82590366
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.75236276
12Drug metabolism - other enzymes_Homo sapiens_hsa009832.74251682
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55392068
14Arginine biosynthesis_Homo sapiens_hsa002202.42832862
15Fatty acid degradation_Homo sapiens_hsa000712.41354016
16Phenylalanine metabolism_Homo sapiens_hsa003602.33919267
17Tyrosine metabolism_Homo sapiens_hsa003502.20206361
18Butanoate metabolism_Homo sapiens_hsa006502.11719657
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03790855
20Tryptophan metabolism_Homo sapiens_hsa003801.92260949
21Histidine metabolism_Homo sapiens_hsa003401.90594476
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.89383344
23Bile secretion_Homo sapiens_hsa049761.86488501
24Starch and sucrose metabolism_Homo sapiens_hsa005001.64779045
25* Linoleic acid metabolism_Homo sapiens_hsa005911.58641194
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.57405336
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56818230
28Vitamin B6 metabolism_Homo sapiens_hsa007501.39189744
29PPAR signaling pathway_Homo sapiens_hsa033201.36765954
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29734973
31Peroxisome_Homo sapiens_hsa041461.28094522
32beta-Alanine metabolism_Homo sapiens_hsa004101.26441784
33Staphylococcus aureus infection_Homo sapiens_hsa051501.26341854
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24398359
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23640156
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.20584906
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19405649
38Prion diseases_Homo sapiens_hsa050201.10335152
39Pyruvate metabolism_Homo sapiens_hsa006201.01408292
40Biosynthesis of amino acids_Homo sapiens_hsa012300.99898887
41* Arachidonic acid metabolism_Homo sapiens_hsa005900.98285548
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98136158
43Propanoate metabolism_Homo sapiens_hsa006400.93250613
44Arginine and proline metabolism_Homo sapiens_hsa003300.92503878
45Fat digestion and absorption_Homo sapiens_hsa049750.92226479
46ABC transporters_Homo sapiens_hsa020100.84295844
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81848752
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81615423
49Fatty acid metabolism_Homo sapiens_hsa012120.81513607
50Carbon metabolism_Homo sapiens_hsa012000.79343402
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76649426
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75211216
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68370187
54One carbon pool by folate_Homo sapiens_hsa006700.67104644
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.61888943
56Lysine degradation_Homo sapiens_hsa003100.48860628
57Sulfur metabolism_Homo sapiens_hsa009200.48773082
58* Metabolic pathways_Homo sapiens_hsa011000.41593513
59Sulfur relay system_Homo sapiens_hsa041220.34697169
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34030434
61Glycerolipid metabolism_Homo sapiens_hsa005610.32725501
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29456712
63Pertussis_Homo sapiens_hsa051330.28357028
64Vitamin digestion and absorption_Homo sapiens_hsa049770.24691859
65Fructose and mannose metabolism_Homo sapiens_hsa000510.22224262
66Insulin resistance_Homo sapiens_hsa049310.20772579
67Fatty acid elongation_Homo sapiens_hsa000620.20584513
68Pentose phosphate pathway_Homo sapiens_hsa000300.15954718
69Glucagon signaling pathway_Homo sapiens_hsa049220.11471688
70Renin-angiotensin system_Homo sapiens_hsa046140.11050017
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09153046
72Systemic lupus erythematosus_Homo sapiens_hsa053220.08855834
73Selenocompound metabolism_Homo sapiens_hsa004500.08380939
74Glutathione metabolism_Homo sapiens_hsa004800.07849816
75Steroid biosynthesis_Homo sapiens_hsa001000.07473367
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.07247774
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.04694432
78Fatty acid biosynthesis_Homo sapiens_hsa000610.03254338
79Mineral absorption_Homo sapiens_hsa049780.02727694
80Galactose metabolism_Homo sapiens_hsa000520.01532868
81Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2579647
82N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2578664
83Protein digestion and absorption_Homo sapiens_hsa04974-0.2399591
84Circadian rhythm_Homo sapiens_hsa04710-0.2269650
85Type II diabetes mellitus_Homo sapiens_hsa04930-0.2176485
86Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2172219
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1932860
88Ether lipid metabolism_Homo sapiens_hsa00565-0.1889368
89Insulin signaling pathway_Homo sapiens_hsa04910-0.1783569
90Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1672186
91Sphingolipid metabolism_Homo sapiens_hsa00600-0.1482305
92African trypanosomiasis_Homo sapiens_hsa05143-0.1265826
93Nitrogen metabolism_Homo sapiens_hsa00910-0.1086905
94* Serotonergic synapse_Homo sapiens_hsa04726-0.0824710
95Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0798893
96Amoebiasis_Homo sapiens_hsa05146-0.0582645
97Other glycan degradation_Homo sapiens_hsa00511-0.0552634
98Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0232790
99Folate biosynthesis_Homo sapiens_hsa00790-0.0164852
100AMPK signaling pathway_Homo sapiens_hsa04152-0.0088756

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