ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	complement activation, alternative pathway (GO:0006957)	8.50240841
2	omega-hydroxylase P450 pathway (GO:0097267)	8.41423317
3	epoxygenase P450 pathway (GO:0019373)	8.27952554
4	drug catabolic process (GO:0042737)	8.07474919
5	exogenous drug catabolic process (GO:0042738)	8.06726565
6	regulation of protein activation cascade (GO:2000257)	7.58525108
7	regulation of fibrinolysis (GO:0051917)	7.55592397
8	regulation of complement activation (GO:0030449)	7.26281345
9	L-phenylalanine catabolic process (GO:0006559)	7.16842309
10	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.16842309
11	glyoxylate metabolic process (GO:0046487)	6.92580511
12	negative regulation of fibrinolysis (GO:0051918)	6.88058326
13	regulation of plasminogen activation (GO:0010755)	6.41966703
14	protein carboxylation (GO:0018214)	6.34338886
15	peptidyl-glutamic acid carboxylation (GO:0017187)	6.34338886
16	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.31658505
17	L-phenylalanine metabolic process (GO:0006558)	6.31658505
18	serine family amino acid catabolic process (GO:0009071)	5.84676380
19	opsonization (GO:0008228)	5.82767759
20	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.78764349
21	urea metabolic process (GO:0019627)	5.74987911
22	ethanol oxidation (GO:0006069)	5.64175667
23	fibrinolysis (GO:0042730)	5.61922838
24	regulation of triglyceride catabolic process (GO:0010896)	5.58574897
25	drug metabolic process (GO:0017144)	5.47612940
26	imidazole-containing compound metabolic process (GO:0052803)	5.36643840
27	nitrogen cycle metabolic process (GO:0071941)	5.32481925
28	oxidative demethylation (GO:0070989)	5.30320727
29	acute-phase response (GO:0006953)	5.23779660
30	protein activation cascade (GO:0072376)	5.20191527
31	complement activation (GO:0006956)	5.18139785
32	blood coagulation, intrinsic pathway (GO:0007597)	5.12343527
33	aromatic amino acid family catabolic process (GO:0009074)	5.10867642
34	positive regulation of triglyceride lipase activity (GO:0061365)	4.99971554
35	positive regulation of lipoprotein lipase activity (GO:0051006)	4.99971554
36	urea cycle (GO:0000050)	4.94525003
37	complement activation, classical pathway (GO:0006958)	4.92068469
38	regulation of humoral immune response (GO:0002920)	4.91109118
39	negative regulation of sterol transport (GO:0032372)	4.87583957
40	negative regulation of cholesterol transport (GO:0032375)	4.87583957
41	negative regulation of protein activation cascade (GO:2000258)	4.73329487
42	phenylpropanoid metabolic process (GO:0009698)	4.71212140
43	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	4.68382114
44	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	4.68382114
45	alkaloid metabolic process (GO:0009820)	4.68250539
46	tyrosine metabolic process (GO:0006570)	4.50458033
47	ethanol metabolic process (GO:0006067)	4.47917769
48	bile acid biosynthetic process (GO:0006699)	4.47184990
49	S-adenosylmethionine metabolic process (GO:0046500)	4.46843613
50	cytolysis (GO:0019835)	4.44457294
51	glutamate metabolic process (GO:0006536)	4.42323501
52	macromolecular complex remodeling (GO:0034367)	4.38488544
53	plasma lipoprotein particle remodeling (GO:0034369)	4.38488544
54	protein-lipid complex remodeling (GO:0034368)	4.38488544
55	triglyceride homeostasis (GO:0070328)	4.34984455
56	acylglycerol homeostasis (GO:0055090)	4.34984455
57	glycine metabolic process (GO:0006544)	4.27668206
58	phospholipid efflux (GO:0033700)	4.24890729
59	negative regulation of blood coagulation (GO:0030195)	4.22922123
60	negative regulation of hemostasis (GO:1900047)	4.22922123
61	bile acid metabolic process (GO:0008206)	4.18472332
62	cellular glucuronidation (GO:0052695)	4.10906406
63	negative regulation of complement activation (GO:0045916)	3.97213749
64	high-density lipoprotein particle remodeling (GO:0034375)	3.92816696
65	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.91138792
66	cholesterol efflux (GO:0033344)	3.86898051
67	cysteine metabolic process (GO:0006534)	3.85693182
68	glucuronate metabolic process (GO:0019585)	3.84053011
69	uronic acid metabolic process (GO:0006063)	3.84053011
70	negative regulation of wound healing (GO:0061045)	3.83905070
71	bile acid and bile salt transport (GO:0015721)	3.83782260
72	sulfur amino acid catabolic process (GO:0000098)	3.83279149
73	alpha-amino acid catabolic process (GO:1901606)	3.79103918
74	acute inflammatory response (GO:0002526)	3.77915068
75	negative regulation of coagulation (GO:0050819)	3.73187973
76	regulation of apoptotic cell clearance (GO:2000425)	3.68659127
77	positive regulation of hemostasis (GO:1900048)	3.66575542
78	positive regulation of blood coagulation (GO:0030194)	3.66575542
79	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.66204961
80	regulation of acute inflammatory response (GO:0002673)	3.59340916
81	reverse cholesterol transport (GO:0043691)	3.57218772
82	serine family amino acid metabolic process (GO:0009069)	3.55065455
83	serine family amino acid biosynthetic process (GO:0009070)	3.53624458
84	regulation of cholesterol esterification (GO:0010872)	3.52383631
85	arginine metabolic process (GO:0006525)	3.50463457
86	plasma lipoprotein particle organization (GO:0071827)	3.47307914
87	flavonoid metabolic process (GO:0009812)	3.46935075
88	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.45974376
89	positive regulation of coagulation (GO:0050820)	3.40387874
90	positive regulation of lipid catabolic process (GO:0050996)	3.38893424
91	negative regulation of humoral immune response (GO:0002921)	3.37033682
92	heme transport (GO:0015886)	3.30519026
93	cellular ketone body metabolic process (GO:0046950)	3.27993690
94	tryptophan catabolic process (GO:0006569)	3.27779050
95	indole-containing compound catabolic process (GO:0042436)	3.27779050
96	indolalkylamine catabolic process (GO:0046218)	3.27779050
97	cellular amino acid catabolic process (GO:0009063)	3.27517923
98	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.25700798
99	negative regulation of lipase activity (GO:0060192)	3.24325035
100	protein-lipid complex subunit organization (GO:0071825)	3.22817028

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	7.82644008
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	5.31377184
3	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.60498302
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.57672178
5	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.51845728
6	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.89526371
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.85180579
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.78099180
9	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.77155684
10	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.33058318
11	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.84102944
12	LXR_22292898_ChIP-Seq_THP-1_Human	2.25625026
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.16348233
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.04821148
15	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.86909025
16	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.69314975
17	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.65955797
18	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.58692711
19	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.54869778
20	P68_20966046_ChIP-Seq_HELA_Human	1.47032876
21	VDR_21846776_ChIP-Seq_THP-1_Human	1.45488255
22	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.44947042
23	SMC4_20622854_ChIP-Seq_HELA_Human	1.44873915
24	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.42071591
25	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.41041927
26	DROSHA_22980978_ChIP-Seq_HELA_Human	1.40812513
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.38375873
28	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.35628427
29	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.34789660
30	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.33444911
31	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.33001665
32	CTCF_27219007_Chip-Seq_Bcells_Human	1.32026394
33	BCL6_27268052_Chip-Seq_Bcells_Human	1.30386972
34	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.29539565
35	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.27950569
36	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.24847567
37	E2F1_20622854_ChIP-Seq_HELA_Human	1.23758400
38	BCOR_27268052_Chip-Seq_Bcells_Human	1.23704095
39	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.23568439
40	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.20635867
41	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.18344211
42	TCF7_22412390_ChIP-Seq_EML_Mouse	1.15255105
43	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.15215883
44	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.13785970
45	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.12199139
46	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.11860958
47	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.11089511
48	KDM2B_26808549_Chip-Seq_DND41_Human	1.10335105
49	MAF_26560356_Chip-Seq_TH2_Human	1.09427114
50	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.09233904
51	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.07110427
52	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.06477080
53	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.06024614
54	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.05620263
55	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.04897419
56	SA1_27219007_Chip-Seq_Bcells_Human	1.02602584
57	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.02469695
58	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.01820835
59	PHF8_20622854_ChIP-Seq_HELA_Human	1.00301810
60	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.00088086
61	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99768439
62	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.96756413
63	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.96398989
64	CTCF_20526341_ChIP-Seq_ESCs_Human	0.96131343
65	RAC3_21632823_ChIP-Seq_H3396_Human	0.95974730
66	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95212247
67	UTX_26944678_Chip-Seq_JUKART_Human	0.94875787
68	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	0.93934009
69	MAF_26560356_Chip-Seq_TH1_Human	0.93608162
70	CREB1_26743006_Chip-Seq_LNCaP_Human	0.91836785
71	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.91799446
72	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.91696072
73	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.90982527
74	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.90615992
75	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.88082416
76	MYC_22102868_ChIP-Seq_BL_Human	0.87973787
77	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.87771176
78	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.87274947
79	P300_27268052_Chip-Seq_Bcells_Human	0.85520794
80	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.85499300
81	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.85382576
82	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.85373729
83	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.85098658
84	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.84380295
85	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.84141000
86	OCT4_19829295_ChIP-Seq_ESCs_Human	0.84051031
87	HTT_18923047_ChIP-ChIP_STHdh_Human	0.83633525
88	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.83453196
89	OCT4_20526341_ChIP-Seq_ESCs_Human	0.82555414
90	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.80580579
91	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.80561738
92	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.80536732
93	RACK7_27058665_Chip-Seq_MCF-7_Human	0.80460884
94	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.79870594
95	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.79454980
96	KDM2B_26808549_Chip-Seq_K562_Human	0.79085441
97	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.78697978
98	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.78099901
99	SPI1_20517297_ChIP-Seq_HL60_Human	0.76923763
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.76895437

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.75122065
2	MP0005360_urolithiasis	6.32480670
3	MP0008875_abnormal_xenobiotic_pharmacok	5.11473988
4	MP0005085_abnormal_gallbladder_physiolo	5.02361444
5	MP0003195_calcinosis	4.90087051
6	MP0005365_abnormal_bile_salt	4.75761949
7	MP0002138_abnormal_hepatobiliary_system	4.73232703
8	MP0003252_abnormal_bile_duct	3.46483313
9	MP0003191_abnormal_cellular_cholesterol	2.79165389
10	MP0010329_abnormal_lipoprotein_level	2.65399388
11	MP0001666_abnormal_nutrient_absorption	2.53658068
12	MP0003868_abnormal_feces_composition	2.24146154
13	MP0005332_abnormal_amino_acid	2.10010843
14	MP0005670_abnormal_white_adipose	2.05339049
15	MP0009840_abnormal_foam_cell	1.85406975
16	MP0003436_decreased_susceptibility_to	1.77922991
17	MP0000609_abnormal_liver_physiology	1.75842850
18	MP0002118_abnormal_lipid_homeostasis	1.68621895
19	MP0001764_abnormal_homeostasis	1.57542318
20	MP0002132_abnormal_respiratory_system	1.51400951
21	MP0002876_abnormal_thyroid_physiology	1.49080615
22	MP0001986_abnormal_taste_sensitivity	1.42570485
23	MP0009764_decreased_sensitivity_to	1.33193799
24	MP0003172_abnormal_lysosome_physiology	1.30846331
25	MP0009785_altered_susceptibility_to	1.28257733
26	MP0002971_abnormal_brown_adipose	1.19902940
27	MP0003724_increased_susceptibility_to	1.19795417
28	MP0003806_abnormal_nucleotide_metabolis	1.19180710
29	MP0000604_amyloidosis	1.18065557
30	MP0003656_abnormal_erythrocyte_physiolo	1.17424129
31	MP0003879_abnormal_hair_cell	1.14758881
32	MP0001661_extended_life_span	1.11997503
33	MP0005319_abnormal_enzyme/_coenzyme	1.09877363
34	MP0008469_abnormal_protein_level	1.08540031
35	MP0006292_abnormal_olfactory_placode	1.05121510
36	MP0004019_abnormal_vitamin_homeostasis	1.01076723
37	MP0000598_abnormal_liver_morphology	0.97639032
38	MP0002419_abnormal_innate_immunity	0.97454778
39	MP0009697_abnormal_copulation	0.96638786
40	MP0003303_peritoneal_inflammation	0.94649292
41	MP0009763_increased_sensitivity_to	0.94202080
42	MP0010368_abnormal_lymphatic_system	0.94124726
43	MP0002249_abnormal_larynx_morphology	0.93933951
44	MP0005584_abnormal_enzyme/coenzyme_acti	0.91336185
45	MP0009642_abnormal_blood_homeostasis	0.90158630
46	MP0005025_abnormal_response_to	0.87243410
47	MP0005451_abnormal_body_composition	0.86445645
48	MP0003690_abnormal_glial_cell	0.84804251
49	MP0005535_abnormal_body_temperature	0.83922126
50	MP0009643_abnormal_urine_homeostasis	0.83726512
51	MP0005058_abnormal_lysosome_morphology	0.82311494
52	MP0009765_abnormal_xenobiotic_induced	0.81280665
53	MP0001800_abnormal_humoral_immune	0.80781797
54	MP0003705_abnormal_hypodermis_morpholog	0.79186444
55	MP0008874_decreased_physiological_sensi	0.78873863
56	MP0004130_abnormal_muscle_cell	0.78376704
57	MP0002282_abnormal_trachea_morphology	0.77358982
58	MP0005376_homeostasis/metabolism_phenot	0.77325202
59	MP0005334_abnormal_fat_pad	0.76900978
60	MP0004510_myositis	0.74641794
61	MP0002078_abnormal_glucose_homeostasis	0.71590935
62	MP0001790_abnormal_immune_system	0.71269369
63	MP0005387_immune_system_phenotype	0.71269369
64	MP0008872_abnormal_physiological_respon	0.69536033
65	MP0005464_abnormal_platelet_physiology	0.69070334
66	MP0001845_abnormal_inflammatory_respons	0.68757335
67	MP0009115_abnormal_fat_cell	0.68212095
68	MP0002168_other_aberrant_phenotype	0.67516041
69	MP0003122_maternal_imprinting	0.65392095
70	MP0009333_abnormal_splenocyte_physiolog	0.65313445
71	MP0005000_abnormal_immune_tolerance	0.64575098
72	MP0002928_abnormal_bile_duct	0.64003643
73	MP0001533_abnormal_skeleton_physiology	0.63710266
74	MP0009053_abnormal_anal_canal	0.62177761
75	MP0010155_abnormal_intestine_physiology	0.59948883
76	MP0000371_diluted_coat_color	0.59180803
77	MP0005448_abnormal_energy_balance	0.58091412
78	MP0000678_abnormal_parathyroid_gland	0.56718048
79	MP0003075_altered_response_to	0.56036261
80	MP0002723_abnormal_immune_serum	0.55915402
81	MP0003329_amyloid_beta_deposits	0.54138228
82	MP0005166_decreased_susceptibility_to	0.53880495
83	MP0005636_abnormal_mineral_homeostasis	0.52274533
84	MP0003183_abnormal_peptide_metabolism	0.52264885
85	MP0002332_abnormal_exercise_endurance	0.50210553
86	MP0005266_abnormal_metabolism	0.50065430
87	MP0000249_abnormal_blood_vessel	0.48082109
88	MP0003011_delayed_dark_adaptation	0.48072169
89	MP0005646_abnormal_pituitary_gland	0.47948038
90	MP0002136_abnormal_kidney_physiology	0.47794118
91	MP0000685_abnormal_immune_system	0.47698388
92	MP0002822_catalepsy	0.47547010
93	MP0004883_abnormal_blood_vessel	0.46643482
94	MP0006082_CNS_inflammation	0.45958809
95	MP0005164_abnormal_response_to	0.44269028
96	MP0005666_abnormal_adipose_tissue	0.43287541
97	MP0001915_intracranial_hemorrhage	0.39114862
98	MP0000566_synostosis	0.38582199
99	MP0002452_abnormal_antigen_presenting	0.38566370
100	MP0002970_abnormal_white_adipose	0.38497032

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Complement deficiency (HP:0004431)	9.39511957
2	Deep venous thrombosis (HP:0002625)	8.80592480
3	Abnormality of monocarboxylic acid metabolism (HP:0010996)	8.71141792
4	Abnormality of aromatic amino acid family metabolism (HP:0004338)	8.06685594
5	Prolonged partial thromboplastin time (HP:0003645)	7.96827917
6	Abnormality of complement system (HP:0005339)	7.52904185
7	Hyperlipoproteinemia (HP:0010980)	6.63051939
8	Systemic lupus erythematosus (HP:0002725)	6.53429805
9	Joint hemorrhage (HP:0005261)	6.35298528
10	Hypobetalipoproteinemia (HP:0003563)	6.04219206
11	Conjugated hyperbilirubinemia (HP:0002908)	5.82288560
12	Recurrent gram-negative bacterial infections (HP:0005420)	5.61771283
13	Glomerulonephritis (HP:0000099)	5.01184813
14	Xanthomatosis (HP:0000991)	4.68005774
15	Abnormality of pyrimidine metabolism (HP:0004353)	4.46730949
16	Hypoalphalipoproteinemia (HP:0003233)	4.03423166
17	Hypolipoproteinemia (HP:0010981)	3.89583752
18	Spontaneous abortion (HP:0005268)	3.71164703
19	Abnormality of the common coagulation pathway (HP:0010990)	3.68112347
20	Intrahepatic cholestasis (HP:0001406)	3.62315996
21	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.58471311
22	Abnormality of the intrinsic pathway (HP:0010989)	3.40287810
23	Gingival bleeding (HP:0000225)	3.38862113
24	Nephritis (HP:0000123)	3.37413429
25	Pulmonary embolism (HP:0002204)	3.17968269
26	Thrombophlebitis (HP:0004418)	3.05214728
27	Purpura (HP:0000979)	3.00849802
28	Hemorrhage of the eye (HP:0011885)	3.00202867
29	Delayed CNS myelination (HP:0002188)	2.82813152
30	Hyperglycinemia (HP:0002154)	2.74147206
31	Epidermoid cyst (HP:0200040)	2.67745135
32	Fair hair (HP:0002286)	2.66054700
33	Abnormality of methionine metabolism (HP:0010901)	2.64580190
34	Neonatal hypoglycemia (HP:0001998)	2.63390455
35	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.59285763
36	Hypercholesterolemia (HP:0003124)	2.51357283
37	Myocardial infarction (HP:0001658)	2.48124641
38	Hyperammonemia (HP:0001987)	2.40560758
39	Cholecystitis (HP:0001082)	2.28695421
40	Abnormal gallbladder physiology (HP:0012438)	2.28695421
41	Elevated alkaline phosphatase (HP:0003155)	2.26933380
42	Abnormality of glycine metabolism (HP:0010895)	2.26399102
43	Abnormality of serine family amino acid metabolism (HP:0010894)	2.26399102
44	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.25093530
45	Menorrhagia (HP:0000132)	2.23144008
46	Gangrene (HP:0100758)	2.21361054
47	Increased serum ferritin (HP:0003281)	2.21359487
48	Anorexia (HP:0002039)	2.17894149
49	Abnormality of serum amino acid levels (HP:0003112)	2.16548416
50	Myositis (HP:0100614)	2.15860645
51	Mitral stenosis (HP:0001718)	2.15670740
52	Abnormality of alkaline phosphatase activity (HP:0004379)	2.15344387
53	Hepatocellular carcinoma (HP:0001402)	2.15206267
54	Abnormal enzyme/coenzyme activity (HP:0012379)	2.14161149
55	Epistaxis (HP:0000421)	2.13587341
56	Abnormality of nucleobase metabolism (HP:0010932)	2.13090590
57	Orchitis (HP:0100796)	2.10956779
58	Spontaneous hematomas (HP:0007420)	2.09460710
59	Joint swelling (HP:0001386)	2.07769420
60	Abnormality of iron homeostasis (HP:0011031)	2.07623960
61	Optic neuritis (HP:0100653)	2.04110329
62	Retrobulbar optic neuritis (HP:0100654)	2.04110329
63	Hyperbilirubinemia (HP:0002904)	2.03038380
64	Rickets (HP:0002748)	2.02032591
65	Ketosis (HP:0001946)	1.95515517
66	Osteomalacia (HP:0002749)	1.95343057
67	Generalized aminoaciduria (HP:0002909)	1.94500197
68	Hypochromic anemia (HP:0001931)	1.90307208
69	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.87009372
70	Abnormality of alanine metabolism (HP:0010916)	1.87009372
71	Hyperalaninemia (HP:0003348)	1.87009372
72	Hypochromic microcytic anemia (HP:0004840)	1.85336016
73	Cholelithiasis (HP:0001081)	1.83848881
74	Metabolic acidosis (HP:0001942)	1.79525799
75	Hypophosphatemia (HP:0002148)	1.79385880
76	Recurrent abscess formation (HP:0002722)	1.77552600
77	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.76300860
78	Generalized hypopigmentation of hair (HP:0011358)	1.75216208
79	Abnormality of transition element cation homeostasis (HP:0011030)	1.74947933
80	Fat malabsorption (HP:0002630)	1.74622737
81	Amyloidosis (HP:0011034)	1.73559341
82	Pathologic fracture (HP:0002756)	1.72639980
83	Lymphangioma (HP:0100764)	1.70085807
84	Esophageal varix (HP:0002040)	1.69946935
85	Vascular calcification (HP:0004934)	1.66841373
86	Abnormal gallbladder morphology (HP:0012437)	1.66582238
87	Hypophosphatemic rickets (HP:0004912)	1.64530128
88	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.63488592
89	Abnormality of polysaccharide metabolism (HP:0011012)	1.63488592
90	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.63488592
91	Reticulocytosis (HP:0001923)	1.63479212
92	Hypertriglyceridemia (HP:0002155)	1.61521121
93	Irritability (HP:0000737)	1.61063411
94	Abnormal tarsal ossification (HP:0008369)	1.59819743
95	Meningitis (HP:0001287)	1.59657986
96	Blue irides (HP:0000635)	1.58661851
97	Arthropathy (HP:0003040)	1.55760681
98	Pancreatitis (HP:0001733)	1.55486550
99	Retinal atrophy (HP:0001105)	1.54883483
100	Arterial thrombosis (HP:0004420)	1.50548364

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	4.20409452
2	SIK1	3.00059129
3	MAP4K1	2.94854203
4	TRIB3	2.76038032
5	BLK	2.56087597
6	MAP2K3	2.49532718
7	TNK2	2.47270500
8	FGFR4	2.34838444
9	MAP3K3	2.24253848
10	PRPF4B	2.14719277
11	SIK2	1.90397372
12	RIPK4	1.84961850
13	TYK2	1.83456754
14	IRAK4	1.68599906
15	NTRK3	1.66662887
16	EPHA3	1.66132018
17	SIK3	1.61766241
18	RIPK1	1.54041841
19	MARK2	1.53172906
20	MAP3K11	1.48684766
21	EPHB1	1.48426622
22	DYRK1B	1.33006113
23	TAOK1	1.32675084
24	WNK4	1.31165723
25	DAPK2	1.30922884
26	CAMKK1	1.29322034
27	JAK3	1.25309937
28	MAP3K7	1.21438397
29	MAP2K6	1.13077201
30	TBK1	1.13013045
31	IKBKE	1.12645056
32	PRKD3	1.09844784
33	CDK9	1.09222503
34	MAPK7	1.05894550
35	MAP2K4	1.05591580
36	FGR	1.04128282
37	CSK	1.02432637
38	HIPK2	1.00837663
39	NTRK2	1.00390936
40	PKN2	1.00268412
41	CDC42BPA	0.99093059
42	MAP3K1	0.98821536
43	ITK	0.93393019
44	ZAP70	0.90489496
45	PRKAA2	0.90346100
46	SYK	0.89716967
47	FGFR3	0.88310156
48	IKBKB	0.87578675
49	MAPK12	0.86782137
50	CAMKK2	0.84240990
51	SGK223	0.84130030
52	SGK494	0.84130030
53	PTK6	0.83840894
54	MAP3K6	0.82767638
55	CAMK4	0.81436307
56	GRK6	0.81251901
57	PIK3CA	0.81146173
58	MAPK11	0.80583149
59	CDK12	0.79418560
60	LMTK2	0.79282577
61	MAP3K14	0.78390989
62	WNK1	0.77822845
63	MAPK15	0.76298190
64	JAK2	0.75816853
65	ICK	0.75431799
66	PRKD2	0.75376246
67	PDPK1	0.74876355
68	FES	0.74378105
69	RPS6KA2	0.73412506
70	PDK1	0.73284879
71	JAK1	0.72775893
72	MAP3K13	0.71740135
73	PRKCZ	0.70920333
74	LCK	0.69111318
75	RPS6KL1	0.68100744
76	RPS6KC1	0.68100744
77	FGFR2	0.67939833
78	TYRO3	0.65835103
79	BCKDK	0.65568946
80	CSF1R	0.64375303
81	CHUK	0.64212047
82	BTK	0.64083837
83	DDR2	0.63182250
84	LYN	0.63015375
85	HCK	0.62981216
86	EEF2K	0.62098440
87	TAOK2	0.59607640
88	PRKAA1	0.58834867
89	RPS6KA6	0.58690536
90	SGK2	0.57704671
91	PRKACG	0.57581587
92	SMG1	0.55274983
93	MAP4K2	0.50406512
94	TXK	0.49580098
95	GRK7	0.47864191
96	TAOK3	0.46893632
97	CAMK1D	0.46474586
98	MARK3	0.46392299
99	RET	0.43869345
100	PRKCG	0.43683091

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.58721946
2	Complement and coagulation cascades_Homo sapiens_hsa04610	4.58131422
3	Caffeine metabolism_Homo sapiens_hsa00232	4.30870172
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.45343850
5	Retinol metabolism_Homo sapiens_hsa00830	3.18647745
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.12716277
7	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	3.01109915
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.92887825
9	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.70337996
10	Phenylalanine metabolism_Homo sapiens_hsa00360	2.54875729
11	Chemical carcinogenesis_Homo sapiens_hsa05204	2.53907610
12	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.53162175
13	Fatty acid degradation_Homo sapiens_hsa00071	2.46637277
14	Tyrosine metabolism_Homo sapiens_hsa00350	2.26403350
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.11811676
16	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.11629222
17	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.05960620
18	Histidine metabolism_Homo sapiens_hsa00340	1.93901341
19	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.90652272
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.90202914
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.86504652
22	Butanoate metabolism_Homo sapiens_hsa00650	1.77218735
23	Bile secretion_Homo sapiens_hsa04976	1.76514465
24	Prion diseases_Homo sapiens_hsa05020	1.73225634
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.62188781
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56210153
27	PPAR signaling pathway_Homo sapiens_hsa03320	1.48759468
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.39763568
29	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.29112837
30	ABC transporters_Homo sapiens_hsa02010	1.20996392
31	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.19100026
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.18574827
33	Peroxisome_Homo sapiens_hsa04146	1.17983393
34	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.14479354
35	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.12526324
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06815881
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.05262256
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99815564
39	Other glycan degradation_Homo sapiens_hsa00511	0.98168041
40	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.96975180
41	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.94664796
42	One carbon pool by folate_Homo sapiens_hsa00670	0.92886605
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.88877175
44	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.85896783
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84339876
46	Pertussis_Homo sapiens_hsa05133	0.77643298
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.72857350
48	Arginine and proline metabolism_Homo sapiens_hsa00330	0.67922404
49	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.65279398
50	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.63852893
51	Sulfur relay system_Homo sapiens_hsa04122	0.60041354
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.58513135
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.51962683
54	Carbon metabolism_Homo sapiens_hsa01200	0.51141529
55	Insulin resistance_Homo sapiens_hsa04931	0.48716192
56	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47963093
57	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.41718761
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.41310726
59	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.41270243
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37449116
61	Lysine degradation_Homo sapiens_hsa00310	0.35517381
62	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.35212559
63	Metabolic pathways_Homo sapiens_hsa01100	0.26019629
64	AMPK signaling pathway_Homo sapiens_hsa04152	0.25629850
65	Sulfur metabolism_Homo sapiens_hsa00920	0.24437797
66	Galactose metabolism_Homo sapiens_hsa00052	0.23937787
67	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.20447964
68	Glucagon signaling pathway_Homo sapiens_hsa04922	0.19406557
69	Osteoclast differentiation_Homo sapiens_hsa04380	0.18868847
70	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.17765298
71	Amoebiasis_Homo sapiens_hsa05146	0.15075016
72	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.15006582
73	African trypanosomiasis_Homo sapiens_hsa05143	0.13609457
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.13474858
75	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.13025303
76	Mineral absorption_Homo sapiens_hsa04978	0.12323955
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.11789693
78	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.10805795
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.09620391
80	Serotonergic synapse_Homo sapiens_hsa04726	0.06296414
81	Propanoate metabolism_Homo sapiens_hsa00640	0.05388304
82	Type II diabetes mellitus_Homo sapiens_hsa04930	0.00309939
83	Pentose phosphate pathway_Homo sapiens_hsa00030	0.00010606
84	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	-0.0947292
85	Acute myeloid leukemia_Homo sapiens_hsa05221	-0.0935278
86	Cocaine addiction_Homo sapiens_hsa05030	-0.0901799
87	Jak-STAT signaling pathway_Homo sapiens_hsa04630	-0.0859209
88	T cell receptor signaling pathway_Homo sapiens_hsa04660	-0.0814792
89	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	-0.0808911
90	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	-0.0683132
91	GABAergic synapse_Homo sapiens_hsa04727	-0.0601429
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	-0.0598476
93	Leishmaniasis_Homo sapiens_hsa05140	-0.0550999
94	Tuberculosis_Homo sapiens_hsa05152	-0.0500043
95	Chemokine signaling pathway_Homo sapiens_hsa04062	-0.0340456
96	TNF signaling pathway_Homo sapiens_hsa04668	-0.0174767
97	Insulin signaling pathway_Homo sapiens_hsa04910	-0.0163205
98	Prolactin signaling pathway_Homo sapiens_hsa04917	-0.0104174
99	Collecting duct acid secretion_Homo sapiens_hsa04966	-0.0085633
100	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	-0.0085054

CYP2D7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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