CYP2D8P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.12631290
2negative regulation of cell killing (GO:0031342)7.12631290
3response to muramyl dipeptide (GO:0032495)4.51165214
4regulation of B cell receptor signaling pathway (GO:0050855)4.43890061
5negative regulation of lymphocyte mediated immunity (GO:0002707)4.20174452
6response to peptidoglycan (GO:0032494)3.92466845
7macroautophagy (GO:0016236)3.81170510
8tumor necrosis factor-mediated signaling pathway (GO:0033209)3.79165168
9positive regulation of heat generation (GO:0031652)3.77225154
10activated T cell proliferation (GO:0050798)3.65453954
11positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.55372836
12germinal center formation (GO:0002467)3.52332417
13response to interleukin-15 (GO:0070672)3.52134461
14NIK/NF-kappaB signaling (GO:0038061)3.47270002
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46223265
16cellular response to interleukin-15 (GO:0071350)3.44471379
17negative regulation of leukocyte mediated immunity (GO:0002704)3.44463384
18alkaloid metabolic process (GO:0009820)3.38845720
19histone H3-K4 trimethylation (GO:0080182)3.35791780
20histone H3-K9 modification (GO:0061647)3.35520705
21histone H3-K36 demethylation (GO:0070544)3.35162144
22mannose metabolic process (GO:0006013)3.34591240
23positive regulation of gamma-delta T cell activation (GO:0046645)3.31708205
24phenylpropanoid metabolic process (GO:0009698)3.30394755
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29648477
26antigen processing and presentation of endogenous antigen (GO:0019883)3.27215988
27negative thymic T cell selection (GO:0045060)3.25604958
28negative regulation of T-helper cell differentiation (GO:0045623)3.25187664
29negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.25187664
30positive regulation of bone resorption (GO:0045780)3.21384129
31positive regulation of bone remodeling (GO:0046852)3.21384129
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.20116590
33regulation of immunoglobulin secretion (GO:0051023)3.17956361
34histone H3-K9 methylation (GO:0051567)3.14091555
35negative T cell selection (GO:0043383)3.07093466
36positive regulation of granulocyte differentiation (GO:0030854)3.07038472
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04332866
38regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.03879854
39regulation of natural killer cell mediated immunity (GO:0002715)3.03879854
40alanine transport (GO:0032328)3.00339205
41tolerance induction (GO:0002507)2.98453979
42negative regulation of innate immune response (GO:0045824)2.94544738
43negative regulation of T cell mediated immunity (GO:0002710)2.93502320
44B cell homeostasis (GO:0001782)2.90260037
45positive regulation of natural killer cell mediated immunity (GO:0002717)2.90254717
46neutrophil activation involved in immune response (GO:0002283)2.89730697
47regulation of fever generation (GO:0031620)2.88351280
48T cell proliferation (GO:0042098)2.82449432
49negative regulation of fibrinolysis (GO:0051918)2.81972716
50negative regulation of immunoglobulin mediated immune response (GO:0002890)2.80701604
51negative regulation of B cell mediated immunity (GO:0002713)2.80701604
52regulation of T-helper 2 cell differentiation (GO:0045628)2.78987108
53peptidyl-glutamic acid carboxylation (GO:0017187)2.75357328
54protein carboxylation (GO:0018214)2.75357328
55regulation of gamma-delta T cell activation (GO:0046643)2.75184924
56positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.73141268
57leukocyte aggregation (GO:0070486)2.72397792
58regulation of heat generation (GO:0031650)2.69093945
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.67353266
60pyrimidine dimer repair (GO:0006290)2.66791678
61negative regulation of type 2 immune response (GO:0002829)2.65646862
62regulation of gamma-delta T cell differentiation (GO:0045586)2.64068495
63positive regulation of B cell proliferation (GO:0030890)2.63041746
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62796516
65regulation of fibrinolysis (GO:0051917)2.62398780
66modulation by symbiont of host defense response (GO:0052031)2.62223088
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62223088
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62223088
69positive regulation by organism of defense response of other organism involved in symbiotic interact2.62223088
70modulation by symbiont of host immune response (GO:0052553)2.62223088
71positive regulation by symbiont of host defense response (GO:0052509)2.62223088
72macrophage activation involved in immune response (GO:0002281)2.62109201
73negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.61583294
74thymic T cell selection (GO:0045061)2.60908013
75positive regulation of CREB transcription factor activity (GO:0032793)2.59876384
76regulation of ARF protein signal transduction (GO:0032012)2.58385434
77T cell homeostasis (GO:0043029)2.58043345
78CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.56886088
79regulation of interleukin-6 biosynthetic process (GO:0045408)2.56628093
803-UTR-mediated mRNA stabilization (GO:0070935)2.55035224
81activation of JUN kinase activity (GO:0007257)2.53642855
82T cell selection (GO:0045058)2.52802005
83regulation of interleukin-2 biosynthetic process (GO:0045076)2.52564551
84B cell receptor signaling pathway (GO:0050853)2.52538868
85regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51146358
86neutrophil activation (GO:0042119)2.50767065
87regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.49362657
88histone H3-K9 demethylation (GO:0033169)2.49162047
89histone lysine demethylation (GO:0070076)2.48692748
90regulation of granulocyte differentiation (GO:0030852)2.48143615
91regulation of interferon-beta biosynthetic process (GO:0045357)2.47494310
92positive T cell selection (GO:0043368)2.45362892
93histone demethylation (GO:0016577)2.43587836
94regulation of leukocyte mediated cytotoxicity (GO:0001910)2.42426455
95negative regulation of erythrocyte differentiation (GO:0045647)2.42391619
96histone H3-K4 methylation (GO:0051568)2.40961843
97positive regulation of T cell chemotaxis (GO:0010820)2.40905670
98regulation of T cell chemotaxis (GO:0010819)2.40905670
99positive thymic T cell selection (GO:0045059)2.40764503
100T-helper cell differentiation (GO:0042093)2.40623254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.31848773
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.29270014
3MYC_22102868_ChIP-Seq_BL_Human3.28392630
4VDR_21846776_ChIP-Seq_THP-1_Human3.00912213
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.77766867
6MAF_26560356_Chip-Seq_TH1_Human2.72255619
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.69338510
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.61124564
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56143380
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50180609
11KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.43820271
12KDM2B_26808549_Chip-Seq_DND41_Human2.43166526
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.41728413
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.37386225
15TCF7_22412390_ChIP-Seq_EML_Mouse2.36608902
16UTX_26944678_Chip-Seq_JUKART_Human2.32606917
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31777238
18VDR_24763502_ChIP-Seq_THP-1_Human2.29165778
19LXR_22292898_ChIP-Seq_THP-1_Human2.27709006
20MAF_26560356_Chip-Seq_TH2_Human2.27242839
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.26383371
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20352821
23SCL_19346495_ChIP-Seq_HPC-7_Human2.18997773
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.11375938
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10237918
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06653306
27RUNX_20019798_ChIP-Seq_JUKART_Human2.02237202
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93362750
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90664485
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.87729365
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.82625233
32MYB_26560356_Chip-Seq_TH1_Human1.81819915
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.80728521
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78695198
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76557923
36GATA1_19941827_ChIP-Seq_MEL_Mouse1.73774683
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72971392
38SPI1_23127762_ChIP-Seq_K562_Human1.71854834
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.69365038
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.67487149
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63059146
42MYB_26560356_Chip-Seq_TH2_Human1.60150876
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59615953
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.58141340
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57845236
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56936204
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.55948014
48P68_20966046_ChIP-Seq_HELA_Human1.55853888
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49072951
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.45247542
51SMC4_20622854_ChIP-Seq_HELA_Human1.44816879
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43341795
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43072409
54GATA3_27048872_Chip-Seq_THYMUS_Human1.42841450
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41501221
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40689998
57SPI1_23547873_ChIP-Seq_NB4_Human1.40395712
58KDM2B_26808549_Chip-Seq_K562_Human1.40362113
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36503194
60PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33876113
61BCL6_27268052_Chip-Seq_Bcells_Human1.32613712
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31505598
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30926091
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28779758
65CREB1_26743006_Chip-Seq_LNCaP_Human1.28116964
66NCOR1_26117541_ChIP-Seq_K562_Human1.28079302
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25597781
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25499446
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25363643
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24248109
71VDR_24787735_ChIP-Seq_THP-1_Human1.24128610
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22849121
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22483677
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19376847
75BCOR_27268052_Chip-Seq_Bcells_Human1.17737329
76PHF8_20622854_ChIP-Seq_HELA_Human1.16617731
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16026321
78E2F1_20622854_ChIP-Seq_HELA_Human1.14976805
79CTCF_27219007_Chip-Seq_Bcells_Human1.14092594
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11954514
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11041103
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10157172
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10137158
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08347333
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07382047
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07333229
87RACK7_27058665_Chip-Seq_MCF-7_Human1.07322627
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.06901514
89DROSHA_22980978_ChIP-Seq_HELA_Human1.05912539
90P300_27268052_Chip-Seq_Bcells_Human1.05306784
91SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.02924067
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01775418
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01578872
94SA1_27219007_Chip-Seq_Bcells_Human1.01407565
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00887721
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99683096
97GATA1_19941826_ChIP-Seq_K562_Human0.99506673
98ETS1_21867929_ChIP-Seq_TH2_Mouse0.99306717
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99044194
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98152722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.43544967
2MP0000685_abnormal_immune_system3.36931748
3MP0005360_urolithiasis3.34630779
4MP0003303_peritoneal_inflammation3.21066761
5MP0003724_increased_susceptibility_to2.95237474
6MP0001835_abnormal_antigen_presentation2.61453993
7MP0003763_abnormal_thymus_physiology2.58810199
8MP0001986_abnormal_taste_sensitivity2.55828764
9MP0001790_abnormal_immune_system2.46431352
10MP0005387_immune_system_phenotype2.46431352
11MP0001800_abnormal_humoral_immune2.46000812
12MP0003787_abnormal_imprinting2.33829719
13MP0001873_stomach_inflammation2.30078280
14MP0002139_abnormal_hepatobiliary_system2.25249033
15MP0002723_abnormal_immune_serum2.17943682
16MP0005000_abnormal_immune_tolerance2.07913241
17MP0003172_abnormal_lysosome_physiology2.01141464
18MP0005671_abnormal_response_to1.99670763
19MP0005025_abnormal_response_to1.97680764
20MP0002420_abnormal_adaptive_immunity1.94269611
21MP0001819_abnormal_immune_cell1.92216098
22MP0002419_abnormal_innate_immunity1.87364226
23MP0002452_abnormal_antigen_presenting1.85062599
24MP0002396_abnormal_hematopoietic_system1.84783385
25MP0002009_preneoplasia1.84323193
26MP0002398_abnormal_bone_marrow1.83196704
27MP0000703_abnormal_thymus_morphology1.82594624
28MP0002138_abnormal_hepatobiliary_system1.80395187
29MP0000716_abnormal_immune_system1.80302332
30MP0005058_abnormal_lysosome_morphology1.76255930
31MP0004381_abnormal_hair_follicle1.69028173
32MP0009333_abnormal_splenocyte_physiolog1.65446728
33MP0005365_abnormal_bile_salt1.63753005
34MP0004947_skin_inflammation1.62332472
35MP0005423_abnormal_somatic_nervous1.61589405
36MP0001348_abnormal_lacrimal_gland1.60218188
37MP0002254_reproductive_system_inflammat1.59103545
38MP0005451_abnormal_body_composition1.58670500
39MP0000689_abnormal_spleen_morphology1.58173430
40MP0003195_calcinosis1.56255275
41MP0008057_abnormal_DNA_replication1.50576721
42MP0002405_respiratory_system_inflammati1.48023223
43MP0002722_abnormal_immune_system1.47089280
44MP0005409_darkened_coat_color1.46584555
45MP0001915_intracranial_hemorrhage1.46316454
46MP0003300_gastrointestinal_ulcer1.43292462
47MP0002429_abnormal_blood_cell1.40885980
48MP0009278_abnormal_bone_marrow1.39774159
49MP0003868_abnormal_feces_composition1.38363287
50MP0005464_abnormal_platelet_physiology1.38197325
51MP0003866_abnormal_defecation1.38134669
52MP0006082_CNS_inflammation1.35092155
53MP0008995_early_reproductive_senescence1.28512798
54MP0002148_abnormal_hypersensitivity_rea1.27853158
55MP0001533_abnormal_skeleton_physiology1.25431406
56MP0003786_premature_aging1.23403978
57MP0005310_abnormal_salivary_gland1.21794684
58MP0005076_abnormal_cell_differentiation1.19413425
59MP0009785_altered_susceptibility_to1.15306162
60MP0004808_abnormal_hematopoietic_stem1.14584453
61MP0010155_abnormal_intestine_physiology1.14452421
62MP0009840_abnormal_foam_cell1.12130237
63MP0001845_abnormal_inflammatory_respons1.10449459
64MP0002933_joint_inflammation1.09939205
65MP0002998_abnormal_bone_remodeling1.08598914
66MP0008469_abnormal_protein_level1.07023290
67MP0009764_decreased_sensitivity_to1.07006523
68MP0003252_abnormal_bile_duct1.06702915
69MP0004142_abnormal_muscle_tone1.06414263
70MP0008961_abnormal_basal_metabolism1.06344515
71MP0000003_abnormal_adipose_tissue0.99667053
72MP0003959_abnormal_lean_body0.99292215
73MP0008877_abnormal_DNA_methylation0.97570264
74MP0000609_abnormal_liver_physiology0.96455181
75MP0001853_heart_inflammation0.96075057
76MP0000465_gastrointestinal_hemorrhage0.94178376
77MP0003122_maternal_imprinting0.93906892
78MP0009115_abnormal_fat_cell0.93762962
79MP0004043_abnormal_pH_regulation0.90091345
80MP0005075_abnormal_melanosome_morpholog0.87954546
81MP0003191_abnormal_cellular_cholesterol0.87770698
82MP0005645_abnormal_hypothalamus_physiol0.87518272
83MP0000604_amyloidosis0.85012225
84MP0010329_abnormal_lipoprotein_level0.82423483
85MP0002876_abnormal_thyroid_physiology0.80664716
86MP0002118_abnormal_lipid_homeostasis0.80478099
87MP0003279_aneurysm0.79676587
88MP0009384_cardiac_valve_regurgitation0.79561880
89MP0008875_abnormal_xenobiotic_pharmacok0.79063644
90MP0002166_altered_tumor_susceptibility0.78357836
91MP0002693_abnormal_pancreas_physiology0.77895349
92MP0005647_abnormal_sex_gland0.75190284
93MP0005535_abnormal_body_temperature0.74912235
94MP0003121_genomic_imprinting0.73354213
95MP0002089_abnormal_postnatal_growth/wei0.70078288
96MP0003656_abnormal_erythrocyte_physiolo0.69639046
97MP0003045_fibrosis0.67262911
98MP0005375_adipose_tissue_phenotype0.66354880
99MP0002970_abnormal_white_adipose0.65811966
100MP0001188_hyperpigmentation0.65502937

Predicted human phenotypes

RankGene SetZ-score
1Chronic mucocutaneous candidiasis (HP:0002728)5.12752703
2Recurrent cutaneous fungal infections (HP:0011370)5.12752703
3Persistence of primary teeth (HP:0006335)4.51796935
4Deep venous thrombosis (HP:0002625)4.25847632
5Abnormal tarsal ossification (HP:0008369)3.77433076
6Increased density of long bones (HP:0006392)3.64959339
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.52949508
8Recurrent fungal infections (HP:0002841)3.43623447
9Anteriorly placed anus (HP:0001545)3.28220178
10Hemorrhage of the eye (HP:0011885)3.14935809
11Abnormality of carpal bone ossification (HP:0006257)3.12011772
12Genetic anticipation (HP:0003743)3.04310668
13Cheilitis (HP:0100825)2.97043262
14Panhypogammaglobulinemia (HP:0003139)2.94917623
15Recurrent skin infections (HP:0001581)2.93686846
16Poikiloderma (HP:0001029)2.92734911
17Eczematoid dermatitis (HP:0000976)2.92413296
18Mediastinal lymphadenopathy (HP:0100721)2.89996534
19Flat acetabular roof (HP:0003180)2.88689829
20Thin bony cortex (HP:0002753)2.83144631
21Joint hemorrhage (HP:0005261)2.81103009
22Absent speech (HP:0001344)2.75363484
23Abnormality of monocarboxylic acid metabolism (HP:0010996)2.66693660
24Abnormal foot bone ossification (HP:0010675)2.65499877
25Abnormality of the fingertips (HP:0001211)2.61661553
26Pustule (HP:0200039)2.57586596
27Meningitis (HP:0001287)2.56773630
28Large eyes (HP:0001090)2.56036127
29Colitis (HP:0002583)2.55292373
30Basal cell carcinoma (HP:0002671)2.54584048
31Abnormal ossification of hand bones (HP:0005921)2.50285666
32Myositis (HP:0100614)2.47263261
33Hyperacusis (HP:0010780)2.46094664
34Gastrointestinal infarctions (HP:0005244)2.44969328
35Premature loss of primary teeth (HP:0006323)2.44840208
36Supernumerary nipples (HP:0002558)2.40673857
37Broad face (HP:0000283)2.40614602
38Pulmonary embolism (HP:0002204)2.40187161
39Abnormality of macrophages (HP:0004311)2.35434235
40Increased IgE level (HP:0003212)2.35408161
41Optic neuritis (HP:0100653)2.32749140
42Retrobulbar optic neuritis (HP:0100654)2.32749140
43Abnormality of the columella (HP:0009929)2.30498732
44Slow saccadic eye movements (HP:0000514)2.29666741
45Orchitis (HP:0100796)2.26741047
46Long palpebral fissure (HP:0000637)2.25161285
47Abnormal hand bone ossification (HP:0010660)2.24974867
48Tented upper lip vermilion (HP:0010804)2.23854800
49Gingival bleeding (HP:0000225)2.23183317
50Gastrointestinal inflammation (HP:0004386)2.21976070
51Squamous cell carcinoma (HP:0002860)2.18752476
52Supranuclear gaze palsy (HP:0000605)2.17689145
53Neonatal respiratory distress (HP:0002643)2.12979254
54Prolonged partial thromboplastin time (HP:0003645)2.11027703
55T lymphocytopenia (HP:0005403)2.08941870
56Inflammation of the large intestine (HP:0002037)2.08899184
57Dysostosis multiplex (HP:0000943)2.08255705
58Prolonged bleeding time (HP:0003010)2.07304227
59Recurrent gram-negative bacterial infections (HP:0005420)2.05751036
60Recurrent bacterial skin infections (HP:0005406)2.04136026
61Spontaneous hematomas (HP:0007420)2.03689708
62Neuronal loss in central nervous system (HP:0002529)2.01982630
63Urticaria (HP:0001025)2.01017958
64Elevated alkaline phosphatase (HP:0003155)2.00361986
65Entropion (HP:0000621)1.99615665
66Abnormality of T cell number (HP:0011839)1.99309137
67Urinary glycosaminoglycan excretion (HP:0003541)1.96055870
68Mucopolysacchariduria (HP:0008155)1.96055870
69Bile duct proliferation (HP:0001408)1.95164499
70Abnormal biliary tract physiology (HP:0012439)1.95164499
71Fetal akinesia sequence (HP:0001989)1.93701773
72Obstructive lung disease (HP:0006536)1.93331968
73Chronic obstructive pulmonary disease (HP:0006510)1.93331968
74Hemoptysis (HP:0002105)1.92702158
75Diplopia (HP:0000651)1.92303400
76Abnormality of binocular vision (HP:0011514)1.92303400
77IgG deficiency (HP:0004315)1.91823110
78Abnormality of pyrimidine metabolism (HP:0004353)1.91541032
79Dislocated radial head (HP:0003083)1.91281743
80Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91144155
81Abnormality of polysaccharide metabolism (HP:0011012)1.91144155
82Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91144155
83Ectropion (HP:0000656)1.89963710
84Encephalitis (HP:0002383)1.89862757
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88379514
86Agammaglobulinemia (HP:0004432)1.87498735
87Increased serum ferritin (HP:0003281)1.87261749
88Obstructive sleep apnea (HP:0002870)1.86762680
89Hypophosphatemia (HP:0002148)1.84410490
90Recurrent abscess formation (HP:0002722)1.84183961
91Hypochromic anemia (HP:0001931)1.83356838
92Xanthomatosis (HP:0000991)1.83125613
93Keratitis (HP:0000491)1.82848368
94Viral hepatitis (HP:0006562)1.82006414
95Recurrent viral infections (HP:0004429)1.81569717
96Abnormality of alkaline phosphatase activity (HP:0004379)1.77983419
97Plagiocephaly (HP:0001357)1.77796515
98Abnormality of vision evoked potentials (HP:0000649)1.77438747
99Chronic hepatic failure (HP:0100626)1.77101721
100Vasculitis (HP:0002633)1.75743792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK23.23556103
2MAP4K12.88206862
3TRIB32.68583155
4PRPF4B2.67372807
5SIK32.55114156
6SIK12.45821745
7MAP3K142.01456856
8CDK122.00151401
9FGFR41.97394611
10MARK21.96343773
11FES1.87286470
12ERN11.84642466
13CDC42BPA1.81267035
14TNK21.80448243
15BLK1.80282698
16IKBKE1.74050429
17TYK21.70228983
18RIPK41.66747093
19MAP3K101.56854147
20TAOK11.55414131
21GRK61.48282919
22TESK21.48270439
23CSF1R1.42792202
24JAK31.39009942
25IKBKB1.37402095
26BTK1.35401760
27TXK1.34417714
28FGR1.34093904
29LIMK11.33555214
30IRAK41.31013067
31MAP3K71.30418192
32CAMKK11.25474594
33MAP2K31.25342766
34SYK1.25175734
35TBK11.24052869
36NME11.23754140
37JAK11.21315526
38IRAK21.17764036
39MAPK121.15885249
40ZAP701.15119266
41ICK1.14431079
42PRKD21.09943928
43TLK11.09279086
44WNK40.98947215
45RPS6KA20.95454040
46GRK70.94767673
47BMPR20.93851999
48SMG10.93699910
49FGFR30.93228185
50HCK0.92932192
51WNK10.91692612
52MAP3K60.91387408
53EPHB10.88211700
54CDK90.85688377
55MAP3K110.85627764
56KSR20.85567841
57LYN0.84997665
58LCK0.84086677
59CHUK0.83834528
60DYRK30.83787664
61CDK40.80252071
62CAMK40.77675990
63DYRK1B0.76098986
64CSK0.75181165
65SGK30.75049491
66MAP3K10.74396930
67MAP3K130.72111137
68EEF2K0.70779613
69MAPK130.69748396
70SGK20.69704797
71MARK10.69389296
72MAPK110.69337853
73CCNB10.68899193
74EPHA30.67733387
75BCR0.67664638
76ITK0.67644134
77CAMK1D0.67089181
78MAPK70.65006375
79PRKCH0.64541290
80UHMK10.64491814
81NEK90.63460026
82MATK0.62452066
83DAPK20.62283193
84PINK10.60662483
85TYRO30.59080805
86MAP2K60.58087176
87SGK4940.57378890
88SGK2230.57378890
89MAP2K40.54834911
90MTOR0.54456998
91RET0.54383576
92AKT30.53821040
93BRD40.53547463
94MAPK150.52407543
95IRAK10.52109533
96PRKCZ0.52107283
97MARK30.51576372
98STK380.49432672
99KIT0.48523208
100PDK10.46205252

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.81191971
2Osteoclast differentiation_Homo sapiens_hsa043802.33587420
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.29879022
4Primary immunodeficiency_Homo sapiens_hsa053402.19068130
5Acute myeloid leukemia_Homo sapiens_hsa052212.17822915
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.98507392
7B cell receptor signaling pathway_Homo sapiens_hsa046621.96798985
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80558872
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78907379
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.78737581
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73736078
12T cell receptor signaling pathway_Homo sapiens_hsa046601.70498992
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59467998
14Non-small cell lung cancer_Homo sapiens_hsa052231.56755258
15TNF signaling pathway_Homo sapiens_hsa046681.55862377
16Complement and coagulation cascades_Homo sapiens_hsa046101.54062488
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53092250
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49385009
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43163922
20Prolactin signaling pathway_Homo sapiens_hsa049171.43032521
21Hepatitis B_Homo sapiens_hsa051611.42189952
22Insulin resistance_Homo sapiens_hsa049311.41617198
23Measles_Homo sapiens_hsa051621.35135410
24Tuberculosis_Homo sapiens_hsa051521.27385050
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24160101
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.21382156
27Hepatitis C_Homo sapiens_hsa051601.21168899
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19953752
29Leishmaniasis_Homo sapiens_hsa051401.19809479
30Staphylococcus aureus infection_Homo sapiens_hsa051501.18369635
31Chemokine signaling pathway_Homo sapiens_hsa040621.14197795
32mTOR signaling pathway_Homo sapiens_hsa041501.13703342
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.11503804
34Influenza A_Homo sapiens_hsa051641.11021384
35Pancreatic cancer_Homo sapiens_hsa052121.06748339
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04396363
37Chronic myeloid leukemia_Homo sapiens_hsa052201.04364727
38Endometrial cancer_Homo sapiens_hsa052131.00770987
39Herpes simplex infection_Homo sapiens_hsa051681.00413263
40Neurotrophin signaling pathway_Homo sapiens_hsa047220.98704710
41VEGF signaling pathway_Homo sapiens_hsa043700.98529748
42Choline metabolism in cancer_Homo sapiens_hsa052310.98101505
43Inositol phosphate metabolism_Homo sapiens_hsa005620.97293524
44Pertussis_Homo sapiens_hsa051330.95605127
45Toxoplasmosis_Homo sapiens_hsa051450.92987717
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92908224
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92283897
48Cocaine addiction_Homo sapiens_hsa050300.92255811
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90048598
50Arginine biosynthesis_Homo sapiens_hsa002200.89671055
51Type II diabetes mellitus_Homo sapiens_hsa049300.88192566
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86998038
53Circadian rhythm_Homo sapiens_hsa047100.83032023
54Notch signaling pathway_Homo sapiens_hsa043300.82423951
55Colorectal cancer_Homo sapiens_hsa052100.81425805
56ABC transporters_Homo sapiens_hsa020100.80248404
57Graft-versus-host disease_Homo sapiens_hsa053320.78517513
58Prostate cancer_Homo sapiens_hsa052150.77386878
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.76154069
60Cholinergic synapse_Homo sapiens_hsa047250.75348253
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.75274573
62FoxO signaling pathway_Homo sapiens_hsa040680.74965158
63MAPK signaling pathway_Homo sapiens_hsa040100.74849825
64Hematopoietic cell lineage_Homo sapiens_hsa046400.73441106
65ErbB signaling pathway_Homo sapiens_hsa040120.73228081
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71899944
67GnRH signaling pathway_Homo sapiens_hsa049120.71365838
68Sulfur relay system_Homo sapiens_hsa041220.71096005
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69164695
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69000780
71Renal cell carcinoma_Homo sapiens_hsa052110.68988997
72Apoptosis_Homo sapiens_hsa042100.67234468
73Lysosome_Homo sapiens_hsa041420.65292846
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64137342
75Estrogen signaling pathway_Homo sapiens_hsa049150.63985687
76Fatty acid biosynthesis_Homo sapiens_hsa000610.62269177
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61404291
78Lysine degradation_Homo sapiens_hsa003100.60597248
79Viral carcinogenesis_Homo sapiens_hsa052030.60145990
80Allograft rejection_Homo sapiens_hsa053300.57151408
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56981292
82Type I diabetes mellitus_Homo sapiens_hsa049400.56945265
83Serotonergic synapse_Homo sapiens_hsa047260.56629233
84Glucagon signaling pathway_Homo sapiens_hsa049220.56297239
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56081561
86AMPK signaling pathway_Homo sapiens_hsa041520.55520324
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55104551
88Insulin signaling pathway_Homo sapiens_hsa049100.54632117
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.53578780
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52897558
91Bile secretion_Homo sapiens_hsa049760.50559628
92Shigellosis_Homo sapiens_hsa051310.49428480
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48078693
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47477688
95Autoimmune thyroid disease_Homo sapiens_hsa053200.47405811
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46999443
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.46712744
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.45704245
99Sphingolipid metabolism_Homo sapiens_hsa006000.44341676
100Bladder cancer_Homo sapiens_hsa052190.43739357

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