CYP2E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)9.54564026
2L-phenylalanine catabolic process (GO:0006559)7.55028762
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.55028762
4L-phenylalanine metabolic process (GO:0006558)7.20738842
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20738842
6aromatic amino acid family catabolic process (GO:0009074)6.72426354
7oxidative demethylation (GO:0070989)6.36536027
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.28104799
9* drug metabolic process (GO:0017144)6.23511175
10indole-containing compound catabolic process (GO:0042436)5.97983557
11indolalkylamine catabolic process (GO:0046218)5.97983557
12tryptophan catabolic process (GO:0006569)5.97983557
13ethanol metabolic process (GO:0006067)5.95055128
14kynurenine metabolic process (GO:0070189)5.84298023
15bile acid biosynthetic process (GO:0006699)5.80646408
16glyoxylate metabolic process (GO:0046487)5.71371756
17alpha-linolenic acid metabolic process (GO:0036109)5.70311238
18protein activation cascade (GO:0072376)5.65333650
19tryptophan metabolic process (GO:0006568)5.64856004
20opsonization (GO:0008228)5.56938155
21urea cycle (GO:0000050)5.48661208
22urea metabolic process (GO:0019627)5.48661208
23phenylpropanoid metabolic process (GO:0009698)5.46134951
24high-density lipoprotein particle remodeling (GO:0034375)5.43491743
25cysteine metabolic process (GO:0006534)5.38023125
26complement activation, classical pathway (GO:0006958)5.37958019
27negative regulation of fibrinolysis (GO:0051918)5.35802222
28sulfur amino acid catabolic process (GO:0000098)5.33601587
29peptidyl-glutamic acid carboxylation (GO:0017187)5.19448055
30protein carboxylation (GO:0018214)5.19448055
31complement activation, alternative pathway (GO:0006957)5.15305636
32regulation of fibrinolysis (GO:0051917)5.13616545
33serine family amino acid catabolic process (GO:0009071)5.13439361
34acute-phase response (GO:0006953)5.09738027
35regulation of plasminogen activation (GO:0010755)5.08772280
36nitrogen cycle metabolic process (GO:0071941)5.05389714
37negative regulation of protein activation cascade (GO:2000258)5.05189284
38regulation of humoral immune response (GO:0002920)5.03398573
39bile acid metabolic process (GO:0008206)5.03094477
40regulation of protein activation cascade (GO:2000257)4.99057426
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.96540973
42aromatic amino acid family metabolic process (GO:0009072)4.88413598
43S-adenosylmethionine metabolic process (GO:0046500)4.85858327
44tyrosine metabolic process (GO:0006570)4.80637387
45regulation of cholesterol esterification (GO:0010872)4.77082936
46homocysteine metabolic process (GO:0050667)4.76817442
47lysine metabolic process (GO:0006553)4.74706957
48lysine catabolic process (GO:0006554)4.74706957
49cytolysis (GO:0019835)4.72680173
50amino-acid betaine metabolic process (GO:0006577)4.72563954
51disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.72317667
52killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.72317667
53regulation of triglyceride catabolic process (GO:0010896)4.72190545
54reverse cholesterol transport (GO:0043691)4.72061751
55regulation of complement activation (GO:0030449)4.65963098
56alpha-amino acid catabolic process (GO:1901606)4.64877548
57protein-lipid complex remodeling (GO:0034368)4.64801132
58macromolecular complex remodeling (GO:0034367)4.64801132
59plasma lipoprotein particle remodeling (GO:0034369)4.64801132
60negative regulation of hemostasis (GO:1900047)4.60353647
61negative regulation of blood coagulation (GO:0030195)4.60353647
62acylglycerol homeostasis (GO:0055090)4.58789582
63triglyceride homeostasis (GO:0070328)4.58789582
64cellular ketone body metabolic process (GO:0046950)4.56649249
65negative regulation of cholesterol transport (GO:0032375)4.55383163
66negative regulation of sterol transport (GO:0032372)4.55383163
67phospholipid efflux (GO:0033700)4.41500743
68plasma lipoprotein particle clearance (GO:0034381)4.40689081
69alkaloid metabolic process (GO:0009820)4.34182427
70glycine metabolic process (GO:0006544)4.30924379
71cellular amino acid catabolic process (GO:0009063)4.29765838
72bile acid and bile salt transport (GO:0015721)4.27472489
73cellular glucuronidation (GO:0052695)4.27209992
74drug catabolic process (GO:0042737)4.26129425
75indolalkylamine metabolic process (GO:0006586)4.24455637
76coenzyme catabolic process (GO:0009109)4.24370613
77negative regulation of complement activation (GO:0045916)4.23426167
78positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.21604002
79negative regulation of wound healing (GO:0061045)4.21353453
80glutamate metabolic process (GO:0006536)4.17401060
81negative regulation of coagulation (GO:0050819)4.17288621
82serine family amino acid metabolic process (GO:0009069)4.15825190
83imidazole-containing compound metabolic process (GO:0052803)4.14443305
84cellular biogenic amine catabolic process (GO:0042402)4.13838014
85amine catabolic process (GO:0009310)4.13838014
86cholesterol efflux (GO:0033344)4.08929313
87ethanol oxidation (GO:0006069)4.07333461
88benzene-containing compound metabolic process (GO:0042537)4.07298064
89cellular modified amino acid catabolic process (GO:0042219)4.04272927
90hormone catabolic process (GO:0042447)4.00518944
91low-density lipoprotein particle remodeling (GO:0034374)3.96136364
92ketone body metabolic process (GO:1902224)3.95117945
93serine family amino acid biosynthetic process (GO:0009070)3.95091980
94aldehyde catabolic process (GO:0046185)3.92598573
95dicarboxylic acid biosynthetic process (GO:0043650)3.91465265
96arginine metabolic process (GO:0006525)3.91026953
97short-chain fatty acid metabolic process (GO:0046459)3.88403213
98positive regulation of hemostasis (GO:1900048)3.85996015
99positive regulation of blood coagulation (GO:0030194)3.85996015
100plasma lipoprotein particle assembly (GO:0034377)3.85442727
101fibrinolysis (GO:0042730)3.82591930
102carboxylic acid catabolic process (GO:0046395)3.81786775
103organic acid catabolic process (GO:0016054)3.81786775
104uronic acid metabolic process (GO:0006063)3.81228058
105glucuronate metabolic process (GO:0019585)3.81228058
106positive regulation of lipid catabolic process (GO:0050996)3.80864557
107acute inflammatory response (GO:0002526)3.80038981
108regulation of bile acid biosynthetic process (GO:0070857)3.79933528
109exogenous drug catabolic process (GO:0042738)3.77337723
110acetyl-CoA metabolic process (GO:0006084)3.74750843
111negative regulation of lipase activity (GO:0060192)3.74524590
112cholesterol homeostasis (GO:0042632)3.71949981
113flavonoid metabolic process (GO:0009812)3.69281817
114phospholipid homeostasis (GO:0055091)3.68514212
115positive regulation of lipoprotein lipase activity (GO:0051006)3.66540378
116positive regulation of triglyceride lipase activity (GO:0061365)3.66540378
117cofactor catabolic process (GO:0051187)3.66355246
118sterol homeostasis (GO:0055092)3.66349619
119regulation of cholesterol homeostasis (GO:2000188)3.64838440
120positive regulation of fatty acid beta-oxidation (GO:0032000)3.62864636
121blood coagulation, intrinsic pathway (GO:0007597)3.61733046
122very-low-density lipoprotein particle assembly (GO:0034379)3.59925022
123regulation of acute inflammatory response (GO:0002673)3.59308886
124drug transmembrane transport (GO:0006855)3.59137689
125monocarboxylic acid catabolic process (GO:0072329)3.58602286
126complement activation (GO:0006956)3.57982236
127epoxygenase P450 pathway (GO:0019373)3.56330426
128fatty acid oxidation (GO:0019395)3.56311942
129steroid catabolic process (GO:0006706)3.55637171
130positive regulation of coagulation (GO:0050820)3.54710749
131* xenobiotic metabolic process (GO:0006805)3.48366047
132response to mercury ion (GO:0046689)3.44688809
133positive regulation of fatty acid biosynthetic process (GO:0045723)3.38056151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.36226706
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13987171
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.73731066
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.48965673
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.47607291
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23299469
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.95618356
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.96937572
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.88705293
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24652618
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10309054
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7255098
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97094977
14CLOCK_20551151_ChIP-Seq_293T_Human1.74819075
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.60725561
16GATA1_22025678_ChIP-Seq_K562_Human1.50009945
17* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40110952
18* HTT_18923047_ChIP-ChIP_STHdh_Human1.36770749
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25885383
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23766756
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18991604
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.18121047
23RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16562305
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16418753
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05699299
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02621159
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01252741
28CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01203669
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00386040
30HNFA_21074721_ChIP-Seq_CACO-2_Human0.94622763
31NFE2_27457419_Chip-Seq_LIVER_Mouse0.94556256
32SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93648125
33RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92144421
34IRF1_19129219_ChIP-ChIP_H3396_Human0.91750933
35PHF8_20622853_ChIP-Seq_HELA_Human0.91151379
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89683226
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89228664
38GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88945648
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88361967
40IRF8_22096565_ChIP-ChIP_GC-B_Human0.85070288
41AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84478108
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84201826
43GATA6_21074721_ChIP-Seq_CACO-2_Human0.83131882
44GATA4_25053715_ChIP-Seq_YYC3_Human0.82719615
45NFYA_21822215_ChIP-Seq_K562_Human0.80279082
46EZH2_27294783_Chip-Seq_NPCs_Mouse0.79614331
47* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77937325
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77443714
49SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76399432
50KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76047251
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76014752
52SOX2_21211035_ChIP-Seq_LN229_Human0.75313250
53TP53_18474530_ChIP-ChIP_U2OS_Human0.72394149
54ESR2_21235772_ChIP-Seq_MCF-7_Human0.71920289
55RARA_24833708_ChIP-Seq_LIVER_Mouse0.71369161
56SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69972937
57CBX2_22325352_ChIP-Seq_293T-Rex_Human0.69967513
58ZNF263_19887448_ChIP-Seq_K562_Human0.69770336
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69588437
60SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69351675
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69029049
62ETV2_25802403_ChIP-Seq_MESCs_Mouse0.68387826
63POU3F2_20337985_ChIP-ChIP_501MEL_Human0.67503700
64SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67313759
65SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.67214624
66PIAS1_25552417_ChIP-Seq_VCAP_Human0.67088556
67RAC3_21632823_ChIP-Seq_H3396_Human0.66113748
68CRX_20693478_ChIP-Seq_RETINA_Mouse0.65959302
69ETV1_20927104_ChIP-Seq_GIST48_Human0.65810419
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64767092
71NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64767092
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.64000783
73MYC_19829295_ChIP-Seq_ESCs_Human0.63126249
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62998047
75RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62849556
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62505521
77RARB_24833708_ChIP-Seq_LIVER_Mouse0.61485925
78* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60670638
79CEBPB_22108803_ChIP-Seq_LS180_Human0.60219035
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.59259523
81OCT4_21477851_ChIP-Seq_ESCs_Mouse0.59258024
82SPI1_20517297_ChIP-Seq_HL60_Human0.58956643
83NFYB_21822215_ChIP-Seq_K562_Human0.57963277
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.57906033
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.57817228
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.57709598
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.57697179
88LXR_22292898_ChIP-Seq_THP-1_Human0.57388775
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.57049824
90OCT4_18555785_Chip-Seq_ESCs_Mouse0.57035709
91RUNX1_27457419_Chip-Seq_LIVER_Mouse0.55764802
92PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.55540318
93ESRRB_18555785_Chip-Seq_ESCs_Mouse0.54606372
94ESR1_21235772_ChIP-Seq_MCF-7_Human0.54406300
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.53651066
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.53616181
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53169107
98RBPJ_21746931_ChIP-Seq_IB4_Human0.53018936
99EGR1_19032775_ChIP-ChIP_M12_Human0.52490920
100ERG_20517297_ChIP-Seq_VCAP_Human0.52334462
101MYC_19915707_ChIP-ChIP_AK7_Human0.52267105
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52204741
103FOXA1_25552417_ChIP-Seq_VCAP_Human0.52069676
104SMAD1_18555785_Chip-Seq_ESCs_Mouse0.51870756
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51690344
106P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.51196513
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.51012879
108* ER_23166858_ChIP-Seq_MCF-7_Human0.50971282
109PU1_27457419_Chip-Seq_LIVER_Mouse0.50585983
110ESET_19884257_ChIP-Seq_ESCs_Mouse0.50337936
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50298650
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.50209607
113AR_20517297_ChIP-Seq_VCAP_Human0.50204583
114STAT1_17558387_ChIP-Seq_HELA_Human0.50038040
115* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49280522
116DNAJC2_21179169_ChIP-ChIP_NT2_Human0.49192326
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.47980431
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47287442
119* CBP_21632823_ChIP-Seq_H3396_Human0.46792470
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.46749917
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45931665
122P53_21459846_ChIP-Seq_SAOS-2_Human0.45490511
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.45470613
124GATA1_19941826_ChIP-Seq_K562_Human0.44567857
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42501544
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42457242
127GATA2_19941826_ChIP-Seq_K562_Human0.42194653
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.41798374
129TAF15_26573619_Chip-Seq_HEK293_Human0.41428773
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.41262511
131TAF2_19829295_ChIP-Seq_ESCs_Human0.40420852
132BCAT_22108803_ChIP-Seq_LS180_Human0.39747291
133GATA6_25053715_ChIP-Seq_YYC3_Human0.39130887
134ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.38922530
135* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38686103
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.38479220
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37540182
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.36683280
139STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36618294
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.36231448
141LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35983652
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.35973160
143CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35438463
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.35377139
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.35261064
146CDX2_22108803_ChIP-Seq_LS180_Human0.35174912
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.34941418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.37097753
2MP0005360_urolithiasis7.52757961
3MP0005085_abnormal_gallbladder_physiolo6.33616383
4MP0005365_abnormal_bile_salt6.10803882
5* MP0008875_abnormal_xenobiotic_pharmacok5.02452138
6MP0003806_abnormal_nucleotide_metabolis4.05161662
7MP0003252_abnormal_bile_duct3.85814927
8MP0010329_abnormal_lipoprotein_level3.63082353
9MP0009840_abnormal_foam_cell3.18892995
10MP0005083_abnormal_biliary_tract2.99765019
11MP0005332_abnormal_amino_acid2.87565758
12MP0003195_calcinosis2.84609752
13MP0001666_abnormal_nutrient_absorption2.52648786
14MP0003191_abnormal_cellular_cholesterol2.30059321
15MP0004019_abnormal_vitamin_homeostasis2.27614867
16MP0002118_abnormal_lipid_homeostasis2.16880066
17* MP0000609_abnormal_liver_physiology2.14703350
18MP0002138_abnormal_hepatobiliary_system1.97350529
19MP0005319_abnormal_enzyme/_coenzyme1.86572046
20MP0003868_abnormal_feces_composition1.80116466
21MP0001764_abnormal_homeostasis1.69482278
22MP0005584_abnormal_enzyme/coenzyme_acti1.61568527
23MP0005451_abnormal_body_composition1.56243270
24MP0009697_abnormal_copulation1.45809883
25MP0003186_abnormal_redox_activity1.36812882
26MP0009643_abnormal_urine_homeostasis1.35431768
27MP0003011_delayed_dark_adaptation1.28230549
28MP0002132_abnormal_respiratory_system1.26371478
29MP0005670_abnormal_white_adipose1.26122007
30MP0003656_abnormal_erythrocyte_physiolo1.21535396
31MP0003705_abnormal_hypodermis_morpholog1.17828175
32* MP0000598_abnormal_liver_morphology1.14961204
33MP0005647_abnormal_sex_gland1.12279955
34MP0000604_amyloidosis1.05041203
35MP0002254_reproductive_system_inflammat0.99470176
36MP0005636_abnormal_mineral_homeostasis0.97009843
37MP0002876_abnormal_thyroid_physiology0.97003037
38* MP0009763_increased_sensitivity_to0.96761999
39MP0005187_abnormal_penis_morphology0.93862034
40MP0004130_abnormal_muscle_cell0.93394968
41MP0002282_abnormal_trachea_morphology0.91518292
42MP0008469_abnormal_protein_level0.87544553
43* MP0009764_decreased_sensitivity_to0.87394413
44MP0006036_abnormal_mitochondrial_physio0.87306884
45* MP0009642_abnormal_blood_homeostasis0.87123491
46MP0002971_abnormal_brown_adipose0.86386993
47MP0010368_abnormal_lymphatic_system0.86195075
48MP0002078_abnormal_glucose_homeostasis0.83527692
49MP0001915_intracranial_hemorrhage0.83434333
50MP0001661_extended_life_span0.81685646
51MP0005408_hypopigmentation0.80262890
52MP0005334_abnormal_fat_pad0.80259181
53MP0005376_homeostasis/metabolism_phenot0.78775710
54MP0005535_abnormal_body_temperature0.77476848
55MP0005084_abnormal_gallbladder_morpholo0.77173857
56MP0003690_abnormal_glial_cell0.74399456
57MP0003879_abnormal_hair_cell0.72774925
58MP0001756_abnormal_urination0.72156504
59MP0002249_abnormal_larynx_morphology0.71818850
60MP0005666_abnormal_adipose_tissue0.68233878
61MP0005220_abnormal_exocrine_pancreas0.66442294
62* MP0009765_abnormal_xenobiotic_induced0.65087373
63MP0003329_amyloid_beta_deposits0.64258425
64MP0005266_abnormal_metabolism0.63621177
65MP0009785_altered_susceptibility_to0.62292634
66MP0005448_abnormal_energy_balance0.61349887
67MP0009053_abnormal_anal_canal0.60352084
68MP0002837_dystrophic_cardiac_calcinosis0.57694789
69MP0000639_abnormal_adrenal_gland0.57275198
70MP0002136_abnormal_kidney_physiology0.55325290
71MP0006035_abnormal_mitochondrial_morpho0.54326858
72MP0005464_abnormal_platelet_physiology0.50119158
73MP0003638_abnormal_response/metabolism_0.49854600
74MP0005395_other_phenotype0.48468295
75MP0004782_abnormal_surfactant_physiolog0.48154050
76MP0003724_increased_susceptibility_to0.47329867
77MP0009115_abnormal_fat_cell0.46805168
78MP0005023_abnormal_wound_healing0.46263251
79MP0002928_abnormal_bile_duct0.46086437
80MP0002332_abnormal_exercise_endurance0.45667400
81MP0002822_catalepsy0.45473738
82MP0003953_abnormal_hormone_level0.45331478
83MP0008873_increased_physiological_sensi0.43854476
84MP0009672_abnormal_birth_weight0.41468381
85MP0003075_altered_response_to0.40813352
86MP0003436_decreased_susceptibility_to0.40454540
87MP0002970_abnormal_white_adipose0.39991335
88* MP0008874_decreased_physiological_sensi0.39219855
89MP0005248_abnormal_Harderian_gland0.38821915
90MP0003718_maternal_effect0.38748363
91MP0000230_abnormal_systemic_arterial0.38639221
92MP0000467_abnormal_esophagus_morphology0.38139018
93MP0002168_other_aberrant_phenotype0.37876186
94* MP0008872_abnormal_physiological_respon0.34945482
95MP0002796_impaired_skin_barrier0.34572508
96MP0000249_abnormal_blood_vessel0.34167307
97MP0001853_heart_inflammation0.33975192
98MP0005058_abnormal_lysosome_morphology0.32740046
99MP0005166_decreased_susceptibility_to0.32606649
100MP0001881_abnormal_mammary_gland0.31546902
101MP0001243_abnormal_dermal_layer0.31144592
102MP0004883_abnormal_blood_vessel0.29922056
103MP0004043_abnormal_pH_regulation0.29274120
104MP0004185_abnormal_adipocyte_glucose0.28384897
105MP0006082_CNS_inflammation0.27850292
106MP0001845_abnormal_inflammatory_respons0.26855826
107MP0001545_abnormal_hematopoietic_system0.26309967
108MP0005397_hematopoietic_system_phenotyp0.26309967
109MP0003959_abnormal_lean_body0.26017456
110MP0001765_abnormal_ion_homeostasis0.25839914
111MP0002060_abnormal_skin_morphology0.25767244
112MP0005164_abnormal_response_to0.25553274
113MP0005167_abnormal_blood-brain_barrier0.25331138
114MP0001986_abnormal_taste_sensitivity0.24752384
115MP0002090_abnormal_vision0.24646586
116MP0000566_synostosis0.21515571
117MP0001851_eye_inflammation0.20949939
118MP0003633_abnormal_nervous_system0.19751303
119MP0010386_abnormal_urinary_bladder0.18694890
120MP0002128_abnormal_blood_circulation0.18503103
121MP0001440_abnormal_grooming_behavior0.18439453
122MP0002089_abnormal_postnatal_growth/wei0.18259812
123MP0005197_abnormal_uvea_morphology0.17329904

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.34334918
2Deep venous thrombosis (HP:0002625)7.19685413
3Intrahepatic cholestasis (HP:0001406)7.02704489
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.46587279
5Prolonged partial thromboplastin time (HP:0003645)6.25721206
6Xanthomatosis (HP:0000991)6.24134636
7Hypobetalipoproteinemia (HP:0003563)6.17272410
8Hyperlipoproteinemia (HP:0010980)5.58135681
9Complement deficiency (HP:0004431)5.08634385
10Hypolipoproteinemia (HP:0010981)4.69538594
11Hyperammonemia (HP:0001987)4.68929822
12Joint hemorrhage (HP:0005261)4.61726862
13Hyperglycinemia (HP:0002154)4.51751584
14Epidermoid cyst (HP:0200040)4.50239261
15Ketosis (HP:0001946)4.44163846
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.33235673
17Hyperglycinuria (HP:0003108)4.28623576
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.27627467
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.22961582
20Abnormality of methionine metabolism (HP:0010901)4.22949856
21Abnormality of the common coagulation pathway (HP:0010990)4.22101226
22Hypoalphalipoproteinemia (HP:0003233)4.19772296
23Abnormality of serine family amino acid metabolism (HP:0010894)4.18550701
24Abnormality of glycine metabolism (HP:0010895)4.18550701
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.17891135
26Nephritis (HP:0000123)3.96792573
27Fat malabsorption (HP:0002630)3.91004632
28Hypoglycemic coma (HP:0001325)3.89472678
29Abnormality of pyrimidine metabolism (HP:0004353)3.76470225
30Hypercholesterolemia (HP:0003124)3.69671253
31Abnormality of complement system (HP:0005339)3.69329145
32Abnormality of the intrinsic pathway (HP:0010989)3.57560049
33Conjugated hyperbilirubinemia (HP:0002908)3.57112896
34Abnormality of fatty-acid metabolism (HP:0004359)3.51616879
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.46336622
36Hyperbilirubinemia (HP:0002904)3.29913616
37Delayed CNS myelination (HP:0002188)3.25155178
38Ketoacidosis (HP:0001993)3.23051119
39Abnormality of nucleobase metabolism (HP:0010932)3.18198556
40Abnormality of serum amino acid levels (HP:0003112)3.11219579
41Neonatal hypoglycemia (HP:0001998)2.94943613
42Myocardial infarction (HP:0001658)2.93346993
43Hepatocellular carcinoma (HP:0001402)2.92972287
44Steatorrhea (HP:0002570)2.92915902
45Abnormality of purine metabolism (HP:0004352)2.89062722
46Metabolic acidosis (HP:0001942)2.85341104
47Skin nodule (HP:0200036)2.78263159
48Spontaneous abortion (HP:0005268)2.76873303
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.73801976
50Dicarboxylic aciduria (HP:0003215)2.73801976
51Hypochromic microcytic anemia (HP:0004840)2.73115130
52Osteomalacia (HP:0002749)2.71848897
53Vascular calcification (HP:0004934)2.69030387
54Lethargy (HP:0001254)2.68101713
55Fair hair (HP:0002286)2.67945190
56Gout (HP:0001997)2.64640682
57Systemic lupus erythematosus (HP:0002725)2.64242692
58Reduced antithrombin III activity (HP:0001976)2.62260996
59Spastic diplegia (HP:0001264)2.50983153
60Pulmonary embolism (HP:0002204)2.48585591
61Hypoglycemic seizures (HP:0002173)2.44077468
62Glomerulonephritis (HP:0000099)2.43592534
63Cerebral edema (HP:0002181)2.42619046
64Abnormal gallbladder morphology (HP:0012437)2.39894850
65Purpura (HP:0000979)2.39884491
66Cardiovascular calcification (HP:0011915)2.39793146
67Irritability (HP:0000737)2.38180437
68Mitral stenosis (HP:0001718)2.37122206
69Acanthocytosis (HP:0001927)2.34720794
70Cholelithiasis (HP:0001081)2.34466688
71Neonatal onset (HP:0003623)2.33883162
72Generalized aminoaciduria (HP:0002909)2.28538135
73Malnutrition (HP:0004395)2.28185791
74Abnormal gallbladder physiology (HP:0012438)2.23992410
75Cholecystitis (HP:0001082)2.23992410
76Pancreatitis (HP:0001733)2.20664401
77Amyloidosis (HP:0011034)2.19887469
78Late onset (HP:0003584)2.18866418
79Brushfield spots (HP:0001088)2.18586077
80Vomiting (HP:0002013)2.16193133
81Esophageal varix (HP:0002040)2.15977865
82Sensorimotor neuropathy (HP:0007141)2.15536377
83Enlarged kidneys (HP:0000105)2.14540164
84Abnormality of proline metabolism (HP:0010907)2.11116377
85Hydroxyprolinuria (HP:0003080)2.11116377
86Menorrhagia (HP:0000132)2.07514125
87Hemorrhage of the eye (HP:0011885)2.05856062
88Recurrent gram-negative bacterial infections (HP:0005420)2.05737514
89Opisthotonus (HP:0002179)2.04127931
90Gingival bleeding (HP:0000225)2.01953219
91Elevated alkaline phosphatase (HP:0003155)2.01707036
92Thrombophlebitis (HP:0004418)1.99036621
93Rickets (HP:0002748)1.98533220
94Hyperphosphaturia (HP:0003109)1.98025073
95Alkalosis (HP:0001948)1.97184842
96Abnormality of iron homeostasis (HP:0011031)1.97058520
97Hyperinsulinemic hypoglycemia (HP:0000825)1.96003016
98Abnormal cartilage morphology (HP:0002763)1.94852725
99Abnormality of the gallbladder (HP:0005264)1.94331822
100Proximal tubulopathy (HP:0000114)1.93588955
101Arthropathy (HP:0003040)1.92162581
102Poikilocytosis (HP:0004447)1.91603846
103Increased serum ferritin (HP:0003281)1.91504656
104Generalized hypopigmentation of hair (HP:0011358)1.90192789
105Renal cortical cysts (HP:0000803)1.88595470
106Hypophosphatemic rickets (HP:0004912)1.88391826
107Joint swelling (HP:0001386)1.86818284
108Hyperuricemia (HP:0002149)1.86489792
109Increased purine levels (HP:0004368)1.86489792
110Abnormality of alkaline phosphatase activity (HP:0004379)1.84863169
111Abnormal enzyme/coenzyme activity (HP:0012379)1.84046247
112Hypertriglyceridemia (HP:0002155)1.83611989
113Elevated hepatic transaminases (HP:0002910)1.82153953
114Status epilepticus (HP:0002133)1.80407876
115Epistaxis (HP:0000421)1.80326813
116Glycosuria (HP:0003076)1.79474775
117Abnormality of transition element cation homeostasis (HP:0011030)1.78703484
118Gangrene (HP:0100758)1.78491939
119Cerebral palsy (HP:0100021)1.75396719
120Abnormality of urine glucose concentration (HP:0011016)1.74302894
121Abnormality of the Achilles tendon (HP:0005109)1.71328928
122Atrioventricular block (HP:0001678)1.70236528
123Abnormality of vitamin metabolism (HP:0100508)1.67370129
124Blue irides (HP:0000635)1.66093352
125Increased mean platelet volume (HP:0011877)1.56544270
126Abnormal urine phosphate concentration (HP:0012599)1.56327232
127Abnormal delivery (HP:0001787)1.53283966
128Bile duct proliferation (HP:0001408)1.52074078
129Abnormal biliary tract physiology (HP:0012439)1.52074078
130Impaired platelet aggregation (HP:0003540)1.45619165
131Abnormal platelet function (HP:0011869)1.45619165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.40206497
2SIK14.85524802
3FGFR44.39517198
4ERN14.08041633
5INSRR3.00560136
6TAOK32.72146869
7ERBB42.40896216
8PKN22.33818018
9MST1R2.31275588
10MAP2K42.30030187
11TRIB32.19009395
12NTRK32.08888385
13FLT31.90985792
14TNK21.83180020
15MAPK111.73681374
16PIK3CG1.72326246
17PRPF4B1.62158937
18LATS11.60040728
19TYK21.56443861
20ABL21.44990813
21FGFR21.43097871
22DAPK21.39859639
23FRK1.38749074
24PTK61.36921616
25NEK91.30986111
26PRKG11.27747598
27KDR1.25823246
28CAMK1D1.25289651
29PRKAA21.25198942
30PINK11.24847389
31JAK21.18672244
32CAMKK21.18462866
33FER1.14734418
34MAP2K31.14333087
35NLK1.14080038
36MAP3K71.13948963
37ARAF1.07487929
38PRKACA1.07007197
39STK38L1.05710577
40GRK61.01928050
41JAK11.00594879
42CAMKK10.99019690
43MAPK40.96599399
44TBK10.96345221
45MAP3K140.93933843
46PRKCZ0.92247914
47BLK0.90391137
48MET0.89773478
49TIE10.89074401
50WNK30.87363549
51CDK60.85962251
52MAP3K30.84955158
53MAPK120.82229726
54ERBB20.82059284
55AKT30.81415826
56EPHB10.80605137
57MAP3K100.77847854
58RIPK10.77466475
59PRKACG0.76704299
60CSK0.76677761
61PRKCB0.73233445
62GSK3A0.73097523
63IRAK30.72741997
64PRKAA10.72232081
65SGK30.69406606
66MAP3K110.69014498
67TGFBR20.68451871
68PRKACB0.67698607
69RPS6KA30.67558587
70MAP2K60.67316983
71DYRK1B0.66808381
72CSNK1D0.66094560
73MAPK150.66093503
74CAMK1G0.65876614
75FGFR30.64661489
76PDK30.64215374
77PDK40.64215374
78SGK10.59653969
79EPHA30.59344304
80CAMK2G0.57708505
81PDPK10.56569261
82MAP2K20.54667181
83MAPK70.54650307
84SRC0.54102157
85PTK20.53474636
86CSF1R0.52757446
87ZAP700.51963918
88SGK20.50368276
89KIT0.49932808
90CSNK1E0.47755341
91IGF1R0.47089086
92TAOK20.46889122
93MAP3K60.46733523
94IKBKE0.46484923
95EPHA40.45907479
96PRKCQ0.45557585
97RET0.45135695
98MAP2K10.44128216
99SGK2230.44108275
100SGK4940.44108275
101MAP3K20.43386499
102CSNK1A10.42739426
103CSNK1G10.41541022
104CDK40.41202881
105MAP3K50.40173323
106STK160.39668778
107CSNK2A10.39506112
108GRK10.37868566
109PDK10.36818790
110MAPK30.36773957
111CSNK2A20.36327574
112MTOR0.36079993
113STK380.36053148
114IRAK20.35165745
115MAP3K130.33328319
116PRKCG0.33245952
117PRKCE0.32359112
118GRK70.32158607
119ICK0.32022744
120SCYL20.32008574
121PIK3CA0.29404809
122IRAK10.29257379
123CAMK40.27573858
124EGFR0.26935258
125LATS20.26383731
126PRKCA0.24543589
127PDK20.22614638
128MYLK0.21381778
129ABL10.20956845
130PDGFRA0.19167202
131PKN10.19147494
132MAP3K10.19103736
133CSNK1G20.18949891

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.34613270
2Nitrogen metabolism_Homo sapiens_hsa009103.53797546
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.43658648
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29690154
5Arginine biosynthesis_Homo sapiens_hsa002202.97629295
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.76317942
7Tryptophan metabolism_Homo sapiens_hsa003802.69077141
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66084409
9Complement and coagulation cascades_Homo sapiens_hsa046102.59260394
10Fatty acid degradation_Homo sapiens_hsa000712.56607154
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51630577
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50369597
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35268453
14Butanoate metabolism_Homo sapiens_hsa006502.26436602
15Peroxisome_Homo sapiens_hsa041462.12169737
16Propanoate metabolism_Homo sapiens_hsa006402.08539761
17* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03962672
18PPAR signaling pathway_Homo sapiens_hsa033201.97518323
19Fatty acid metabolism_Homo sapiens_hsa012121.89931060
20Histidine metabolism_Homo sapiens_hsa003401.87651592
21Caffeine metabolism_Homo sapiens_hsa002321.84709496
22* Chemical carcinogenesis_Homo sapiens_hsa052041.83765682
23* Steroid hormone biosynthesis_Homo sapiens_hsa001401.82108141
24beta-Alanine metabolism_Homo sapiens_hsa004101.81682228
25* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81211346
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.77880534
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72034957
28Staphylococcus aureus infection_Homo sapiens_hsa051501.71831797
29Retinol metabolism_Homo sapiens_hsa008301.71576707
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70760592
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70249425
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59769996
33Phenylalanine metabolism_Homo sapiens_hsa003601.59380713
34Selenocompound metabolism_Homo sapiens_hsa004501.52500658
35Bile secretion_Homo sapiens_hsa049761.51232139
36Pyruvate metabolism_Homo sapiens_hsa006201.46149105
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44071697
38Tyrosine metabolism_Homo sapiens_hsa003501.43298979
39Sulfur metabolism_Homo sapiens_hsa009201.34756719
40Fatty acid elongation_Homo sapiens_hsa000621.33731928
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29666276
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.26710737
43ABC transporters_Homo sapiens_hsa020101.20357685
44Biosynthesis of amino acids_Homo sapiens_hsa012301.18230328
45Carbon metabolism_Homo sapiens_hsa012001.16647608
46Folate biosynthesis_Homo sapiens_hsa007901.16000008
47Fat digestion and absorption_Homo sapiens_hsa049751.15875361
48Steroid biosynthesis_Homo sapiens_hsa001001.09108992
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06416153
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.06008418
51* Arachidonic acid metabolism_Homo sapiens_hsa005901.03659137
52Arginine and proline metabolism_Homo sapiens_hsa003300.98786922
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96505835
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95934778
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.92601769
56Sulfur relay system_Homo sapiens_hsa041220.89910661
57Vitamin digestion and absorption_Homo sapiens_hsa049770.87161463
58Vitamin B6 metabolism_Homo sapiens_hsa007500.85984636
59Lysine degradation_Homo sapiens_hsa003100.84775103
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83882668
61Glycerolipid metabolism_Homo sapiens_hsa005610.79440290
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71502124
63One carbon pool by folate_Homo sapiens_hsa006700.68658867
64Glutathione metabolism_Homo sapiens_hsa004800.64307271
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62443947
66Fatty acid biosynthesis_Homo sapiens_hsa000610.62177811
67Pentose phosphate pathway_Homo sapiens_hsa000300.58755223
68* Metabolic pathways_Homo sapiens_hsa011000.45771149
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31993874
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27939639
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.27743669
72Insulin resistance_Homo sapiens_hsa049310.26802704
73Fructose and mannose metabolism_Homo sapiens_hsa000510.25425814
74Prion diseases_Homo sapiens_hsa050200.24339930
75Galactose metabolism_Homo sapiens_hsa000520.22455198
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17723066
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.16264782
78Glucagon signaling pathway_Homo sapiens_hsa049220.12218498
79AMPK signaling pathway_Homo sapiens_hsa041520.08949972
80Amoebiasis_Homo sapiens_hsa051460.04399363
81Serotonergic synapse_Homo sapiens_hsa047260.04260852
82GABAergic synapse_Homo sapiens_hsa04727-0.2796792
83N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2757565
84Protein digestion and absorption_Homo sapiens_hsa04974-0.2592280
85Pertussis_Homo sapiens_hsa05133-0.2588562
86Type II diabetes mellitus_Homo sapiens_hsa04930-0.2552583
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2304160
88Sphingolipid metabolism_Homo sapiens_hsa00600-0.2250824
89Circadian rhythm_Homo sapiens_hsa04710-0.2235458
90Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2118528
91Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2116270
92Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2049566
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1957117
94Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1950157
95Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1888896
96Hepatitis C_Homo sapiens_hsa05160-0.1830316
97African trypanosomiasis_Homo sapiens_hsa05143-0.1689720
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1666820
99Renin-angiotensin system_Homo sapiens_hsa04614-0.1604414
100Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1551279
101Regulation of autophagy_Homo sapiens_hsa04140-0.1408970
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1195422
103Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1156782
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1115772
105Insulin signaling pathway_Homo sapiens_hsa04910-0.0696674
106* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0667396
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0574310
108* Linoleic acid metabolism_Homo sapiens_hsa00591-0.0556643
109Other glycan degradation_Homo sapiens_hsa00511-0.0543110
110Mineral absorption_Homo sapiens_hsa04978-0.0176209

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