CYP2F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.27078921
2regulation of cilium movement (GO:0003352)7.92555788
3primary alcohol catabolic process (GO:0034310)7.47226751
4vitamin transmembrane transport (GO:0035461)7.26164365
5left/right axis specification (GO:0070986)7.22162955
6ventricular system development (GO:0021591)6.69710714
7microtubule bundle formation (GO:0001578)6.48167244
8diterpenoid biosynthetic process (GO:0016102)6.45018405
9ethanol metabolic process (GO:0006067)6.32834856
10intraciliary transport (GO:0042073)6.30781805
11cilium organization (GO:0044782)6.02024381
12response to xenobiotic stimulus (GO:0009410)5.89169715
13tolerance induction (GO:0002507)5.85439432
14cilium assembly (GO:0042384)5.84187528
15one-carbon compound transport (GO:0019755)5.74873809
16pyrimidine-containing compound transmembrane transport (GO:0072531)5.58761693
17centriole assembly (GO:0098534)5.26883849
18lung epithelium development (GO:0060428)5.20803746
19negative regulation of T cell differentiation in thymus (GO:0033085)5.16138957
20protein localization to cilium (GO:0061512)5.02355452
21establishment of apical/basal cell polarity (GO:0035089)4.78664100
22regulation of interleukin-5 production (GO:0032674)4.78062127
23regulation of microtubule-based movement (GO:0060632)4.73399406
24terpenoid biosynthetic process (GO:0016114)4.64963372
25ethanol oxidation (GO:0006069)4.63751251
26sperm capacitation (GO:0048240)4.57950126
27negative regulation of immunoglobulin mediated immune response (GO:0002890)4.57421785
28negative regulation of B cell mediated immunity (GO:0002713)4.57421785
29cellular component assembly involved in morphogenesis (GO:0010927)4.56636133
30microtubule-based movement (GO:0007018)4.56305219
31negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.55142206
32regulation of germinal center formation (GO:0002634)4.54637233
33glomerular epithelial cell development (GO:0072310)4.46477823
34negative regulation of humoral immune response (GO:0002921)4.37836022
35regulation of interleukin-13 production (GO:0032656)4.35635816
36positive regulation of tolerance induction (GO:0002645)4.26952746
37cell projection assembly (GO:0030031)4.24427185
38retinoic acid metabolic process (GO:0042573)4.20460641
39cilium morphogenesis (GO:0060271)4.19411737
40establishment of monopolar cell polarity (GO:0061162)4.19191265
41establishment or maintenance of monopolar cell polarity (GO:0061339)4.19191265
42nucleoside diphosphate phosphorylation (GO:0006165)4.08921376
43exogenous drug catabolic process (GO:0042738)3.93369843
44cytoplasmic microtubule organization (GO:0031122)3.91997875
45microtubule depolymerization (GO:0007019)3.85396378
46microtubule polymerization or depolymerization (GO:0031109)3.64876248
47negative regulation of inclusion body assembly (GO:0090084)3.54742542
48lateral ventricle development (GO:0021670)3.52512777
49establishment of tissue polarity (GO:0007164)3.49186870
50establishment of planar polarity (GO:0001736)3.49186870
51primary alcohol metabolic process (GO:0034308)3.40609518
52O-glycan processing (GO:0016266)3.35885739
53retinol metabolic process (GO:0042572)3.33357136
54glutathione derivative metabolic process (GO:1901685)3.31280682
55glutathione derivative biosynthetic process (GO:1901687)3.31280682
56aldehyde catabolic process (GO:0046185)3.28620775
57hydrogen peroxide biosynthetic process (GO:0050665)3.21004475
58regulation of tolerance induction (GO:0002643)3.15243793
59phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.13638219
60regulation of microtubule depolymerization (GO:0031114)3.09604222
61sperm motility (GO:0030317)3.05450974
62drug catabolic process (GO:0042737)3.04245944
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03198783
64positive regulation of smoothened signaling pathway (GO:0045880)3.02848861
65axonemal dynein complex assembly (GO:0070286)21.9184821
66carnitine metabolic process (GO:0009437)2.98155185
67multicellular organismal water homeostasis (GO:0050891)2.94367384
68determination of left/right symmetry (GO:0007368)2.90555031
69centriole replication (GO:0007099)2.86030882
70oligosaccharide biosynthetic process (GO:0009312)2.86008568
71reactive oxygen species biosynthetic process (GO:1903409)2.84754006
72excretion (GO:0007588)2.81368671
73determination of bilateral symmetry (GO:0009855)2.77825162
74calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.74595319
75microtubule-based process (GO:0007017)2.73566741
76hydrogen peroxide catabolic process (GO:0042744)2.72336790
77lateral sprouting from an epithelium (GO:0060601)2.71426935
78specification of symmetry (GO:0009799)2.70837516
79smoothened signaling pathway (GO:0007224)2.67628476
80progesterone metabolic process (GO:0042448)2.66457145
81phosphatidylcholine biosynthetic process (GO:0006656)2.62827292
82regulation of autophagic vacuole assembly (GO:2000785)2.61294891
83apical protein localization (GO:0045176)2.57989977
84organelle assembly (GO:0070925)2.57962455
85water homeostasis (GO:0030104)2.55271006
86hypotonic response (GO:0006971)2.50219191
87iron ion import (GO:0097286)2.47414170
88rRNA catabolic process (GO:0016075)2.46734661
89negative regulation of microtubule depolymerization (GO:0007026)2.46576933
90protein O-linked glycosylation (GO:0006493)2.45518011
91regulation of response to osmotic stress (GO:0047484)2.45487887
92regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.43933552
93polyol transport (GO:0015791)2.43809880
94regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.42326246
95cilium or flagellum-dependent cell motility (GO:0001539)18.0794629
96cilium movement (GO:0003341)15.6788752
97motile cilium assembly (GO:0044458)14.8440176
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.0447152
99epithelial cilium movement (GO:0003351)13.4827763
100axoneme assembly (GO:0035082)10.2470594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.57751052
2FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.51835357
3DROSHA_22980978_ChIP-Seq_HELA_Human3.42110100
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.35552156
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.20584738
6VDR_22108803_ChIP-Seq_LS180_Human2.53559006
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53306649
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.48166020
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.00949867
10STAT1_20625510_ChIP-Seq_HELA_Human1.96149957
11AHR_22903824_ChIP-Seq_MCF-7_Human1.86316927
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85349741
13FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.84595361
14ESR1_21235772_ChIP-Seq_MCF-7_Human1.83193839
15SMC4_20622854_ChIP-Seq_HELA_Human1.78834870
16TDRD3_21172665_ChIP-Seq_MCF-7_Human1.74434176
17RUNX1_27514584_Chip-Seq_MCF-7_Human1.73186626
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72965811
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.68567241
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67638013
21SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66604081
22AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.65018571
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.64485292
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63439422
25PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.62939338
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.61118939
27TP63_23658742_ChIP-Seq_EP156T_Human1.58226361
28RAD21_21589869_ChIP-Seq_MESCs_Mouse1.57318247
29FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52756486
30ETV1_20927104_ChIP-Seq_GIST48_Human1.52199060
31TP63_22573176_ChIP-Seq_HFKS_Human1.52186229
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49151580
33KLF5_25053715_ChIP-Seq_YYC3_Human1.48678487
34GATA1_19941826_ChIP-Seq_K562_Human1.48285360
35P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47949602
36SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.44956688
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.44015793
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42711422
39PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.39608810
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39442876
41PHF8_20622853_ChIP-Seq_HELA_Human1.38897315
42FOXA1_25552417_ChIP-Seq_VCAP_Human1.37572905
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.36817853
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.34599603
45CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33883861
46SOX2_20726797_ChIP-Seq_SW620_Human1.33421130
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.33414094
48SMRT_27268052_Chip-Seq_Bcells_Human1.32207585
49CTCF_20526341_ChIP-Seq_ESCs_Human1.31703551
50RBPJ_21746931_ChIP-Seq_IB4_Human1.28745828
51GATA4_25053715_ChIP-Seq_YYC3_Human1.25154285
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23427034
53P68_20966046_ChIP-Seq_HELA_Human1.21430159
54PHF8_20622854_ChIP-Seq_HELA_Human1.20997347
55GATA6_21074721_ChIP-Seq_CACO-2_Human1.20422123
56TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19637408
57P300_27268052_Chip-Seq_Bcells_Human1.18853706
58CBX2_22325352_ChIP-Seq_293T-Rex_Human1.18087946
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17456172
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17358932
61CTCF_27219007_Chip-Seq_Bcells_Human1.17118285
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15626623
63CEBPB_22108803_ChIP-Seq_LS180_Human1.14966262
64TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14267766
65FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.13669823
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13229606
67TP53_18474530_ChIP-ChIP_U2OS_Human1.12442528
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11978887
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10754078
70NFYA_21822215_ChIP-Seq_K562_Human1.09381443
71SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08869673
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08074522
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06647115
74GATA3_24758297_ChIP-Seq_MCF-7_Human1.04960799
75RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03575281
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03503727
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.03503727
78AR_20517297_ChIP-Seq_VCAP_Human1.03125448
79E2F1_20622854_ChIP-Seq_HELA_Human1.03098537
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03052285
81NFYB_21822215_ChIP-Seq_K562_Human1.02537724
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.01887793
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01414909
84SOX2_21211035_ChIP-Seq_LN229_Human1.01261879
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.01161845
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00644508
87CREB1_26743006_Chip-Seq_LNCaP_Human0.98239722
88GATA2_19941826_ChIP-Seq_K562_Human0.96372257
89P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96282529
90EZH2_27294783_Chip-Seq_ESCs_Mouse0.94706288
91TBL1_22424771_ChIP-Seq_293T_Human0.93247950
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93073220
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92742157
94TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.91223057
95MYC_19829295_ChIP-Seq_ESCs_Human0.90031567
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89670262
97FLI1_21867929_ChIP-Seq_CD8_Mouse0.89417005
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89206343
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89023238
100OCT4_20526341_ChIP-Seq_ESCs_Human0.87885627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.20461670
2MP0002653_abnormal_ependyma_morphology6.33951714
3MP0002132_abnormal_respiratory_system5.65473616
4MP0004043_abnormal_pH_regulation4.44943944
5MP0002277_abnormal_respiratory_mucosa4.11895900
6MP0009780_abnormal_chondrocyte_physiolo3.94074436
7MP0001984_abnormal_olfaction3.71796133
8MP0004133_heterotaxia3.57943404
9MP0008789_abnormal_olfactory_epithelium3.13885047
10MP0000566_synostosis2.98306363
11MP0005623_abnormal_meninges_morphology2.73831402
12MP0005377_hearing/vestibular/ear_phenot2.30869722
13MP0003878_abnormal_ear_physiology2.30869722
14MP0000383_abnormal_hair_follicle2.22674018
15MP0004019_abnormal_vitamin_homeostasis2.02335334
16MP0001765_abnormal_ion_homeostasis2.02235489
17MP0003656_abnormal_erythrocyte_physiolo2.01295179
18MP0002160_abnormal_reproductive_system1.96705043
19MP0005499_abnormal_olfactory_system1.95264308
20MP0005394_taste/olfaction_phenotype1.95264308
21MP0005083_abnormal_biliary_tract1.87975536
22MP0010678_abnormal_skin_adnexa1.87562416
23MP0002282_abnormal_trachea_morphology1.86592656
24MP0002168_other_aberrant_phenotype1.85180389
25MP0009379_abnormal_foot_pigmentation1.76611090
26MP0000678_abnormal_parathyroid_gland1.59667187
27MP0002909_abnormal_adrenal_gland1.56363054
28MP0000465_gastrointestinal_hemorrhage1.51614473
29MP0001346_abnormal_lacrimal_gland1.49689026
30MP0005636_abnormal_mineral_homeostasis1.45577333
31MP0005395_other_phenotype1.29754210
32MP0010155_abnormal_intestine_physiology1.26159733
33MP0005165_increased_susceptibility_to1.23621063
34MP0002638_abnormal_pupillary_reflex1.20341461
35MP0002822_catalepsy1.19950166
36MP0002735_abnormal_chemical_nociception1.16577056
37MP0002249_abnormal_larynx_morphology1.08723354
38MP0005389_reproductive_system_phenotype1.06321703
39MP0003136_yellow_coat_color1.04291444
40MP0002876_abnormal_thyroid_physiology1.01479871
41MP0002734_abnormal_mechanical_nocicepti0.99943479
42MP0001485_abnormal_pinna_reflex0.99168157
43MP0009643_abnormal_urine_homeostasis0.97222451
44MP0005408_hypopigmentation0.96329162
45MP0001929_abnormal_gametogenesis0.95957063
46MP0005646_abnormal_pituitary_gland0.94553034
47MP0005248_abnormal_Harderian_gland0.91896676
48MP0010030_abnormal_orbit_morphology0.90696946
49MP0005365_abnormal_bile_salt0.87686861
50MP0002136_abnormal_kidney_physiology0.86444073
51MP0003698_abnormal_male_reproductive0.86189264
52MP0005085_abnormal_gallbladder_physiolo0.84051116
53MP0004264_abnormal_extraembryonic_tissu0.81333883
54MP0001293_anophthalmia0.80802420
55MP0002233_abnormal_nose_morphology0.80085680
56MP0000681_abnormal_thyroid_gland0.78531416
57MP0010234_abnormal_vibrissa_follicle0.77023879
58MP0009046_muscle_twitch0.75071813
59MP0003303_peritoneal_inflammation0.73983315
60MP0005164_abnormal_response_to0.72112277
61MP0005310_abnormal_salivary_gland0.70147563
62MP0002098_abnormal_vibrissa_morphology0.68384003
63MP0003866_abnormal_defecation0.68256048
64MP0001664_abnormal_digestion0.65689754
65MP0008872_abnormal_physiological_respon0.65497094
66MP0009765_abnormal_xenobiotic_induced0.64948665
67MP0001188_hyperpigmentation0.63924549
68MP0004883_abnormal_blood_vessel0.61223788
69MP0005551_abnormal_eye_electrophysiolog0.60903374
70MP0001324_abnormal_eye_pigmentation0.60776116
71MP0002139_abnormal_hepatobiliary_system0.60184032
72MP0002405_respiratory_system_inflammati0.59636834
73MP0001663_abnormal_digestive_system0.59332775
74MP0001970_abnormal_pain_threshold0.57833604
75MP0005220_abnormal_exocrine_pancreas0.57068565
76MP0006036_abnormal_mitochondrial_physio0.56109452
77MP0003890_abnormal_embryonic-extraembry0.55612046
78MP0009763_increased_sensitivity_to0.55522180
79MP0008995_early_reproductive_senescence0.55521859
80MP0005253_abnormal_eye_physiology0.54087234
81MP0000467_abnormal_esophagus_morphology0.52762361
82MP0005503_abnormal_tendon_morphology0.52133286
83MP0000026_abnormal_inner_ear0.50779525
84MP0001944_abnormal_pancreas_morphology0.49167537
85MP0002229_neurodegeneration0.48931276
86MP0003718_maternal_effect0.48783141
87MP0005387_immune_system_phenotype0.48588843
88MP0001790_abnormal_immune_system0.48588843
89MP0003195_calcinosis0.47570254
90MP0003075_altered_response_to0.47466051
91MP0004885_abnormal_endolymph0.46487295
92MP0003453_abnormal_keratinocyte_physiol0.45141359
93MP0005409_darkened_coat_color0.44440475
94MP0001270_distended_abdomen0.44233302
95MP0001879_abnormal_lymphatic_vessel0.43889813
96MP0002161_abnormal_fertility/fecundity0.43141047
97MP0002135_abnormal_kidney_morphology0.42694736
98MP0001502_abnormal_circadian_rhythm0.42179717
99MP0002928_abnormal_bile_duct0.41417682
100MP0000858_altered_metastatic_potential0.40858966

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)8.01750498
2Bronchiectasis (HP:0002110)7.46171164
3Nasal polyposis (HP:0100582)6.76932475
4Abnormality of the nasal mucosa (HP:0000433)5.60411842
5Recurrent sinusitis (HP:0011108)4.41658373
6Bronchitis (HP:0012387)4.39116407
7Infertility (HP:0000789)4.28624354
8Chronic sinusitis (HP:0011109)4.14522976
9Male infertility (HP:0003251)4.01141805
10Recurrent otitis media (HP:0000403)3.83628381
11Occipital encephalocele (HP:0002085)3.61280224
12Pancreatic fibrosis (HP:0100732)3.59465661
13True hermaphroditism (HP:0010459)3.48380781
14Hyperactive renin-angiotensin system (HP:0000841)3.15652254
15Chronic otitis media (HP:0000389)3.14218864
16Abnormality of midbrain morphology (HP:0002418)3.02450682
17Molar tooth sign on MRI (HP:0002419)3.02450682
18Atelectasis (HP:0100750)2.98747825
19Pancreatic cysts (HP:0001737)2.93302546
20Cystic liver disease (HP:0006706)2.89555083
21Nephronophthisis (HP:0000090)2.82597970
22Chronic hepatic failure (HP:0100626)2.53507736
23Postaxial foot polydactyly (HP:0001830)2.41518925
24Abnormality of the renal medulla (HP:0100957)2.21317253
25Congenital hepatic fibrosis (HP:0002612)2.08084506
26Anencephaly (HP:0002323)2.05585459
27Decreased circulating renin level (HP:0003351)2.01836549
28Male pseudohermaphroditism (HP:0000037)2.00658015
29Bell-shaped thorax (HP:0001591)2.00642605
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5494720
31Abnormal respiratory motile cilium morphology (HP:0005938)11.2573064
32Abnormal respiratory epithelium morphology (HP:0012253)11.2573064
33Abnormal respiratory motile cilium physiology (HP:0012261)11.0499165
34Dynein arm defect of respiratory motile cilia (HP:0012255)10.8558006
35Absent/shortened dynein arms (HP:0200106)10.8558006
36Abnormal ciliary motility (HP:0012262)10.7895028
37Rhinitis (HP:0012384)10.2133368
38Tubulointerstitial nephritis (HP:0001970)1.98475939
39Aplasia/Hypoplasia of the tongue (HP:0010295)1.98143611
40Renal salt wasting (HP:0000127)1.95596933
41Recurrent bronchitis (HP:0002837)1.89805469
42Asplenia (HP:0001746)1.87103587
43Aplasia/Hypoplasia of the spleen (HP:0010451)1.86278712
44Medial flaring of the eyebrow (HP:0010747)1.84122029
45Furrowed tongue (HP:0000221)1.79385588
46Hyperkalemia (HP:0002153)1.79023712
47Sclerocornea (HP:0000647)1.73108441
48Absent frontal sinuses (HP:0002688)1.69909761
49Oculomotor apraxia (HP:0000657)1.69046627
50Nephropathy (HP:0000112)1.68943213
51Tubular atrophy (HP:0000092)1.67243855
52Congenital primary aphakia (HP:0007707)1.63610253
53Gait imbalance (HP:0002141)1.61100668
54Hyperaldosteronism (HP:0000859)1.60491553
55Abnormality of chloride homeostasis (HP:0011422)1.52581619
56Postaxial hand polydactyly (HP:0001162)1.51392679
57Abnormality of renin-angiotensin system (HP:0000847)1.51392057
58Decreased central vision (HP:0007663)1.43446292
59Nephrogenic diabetes insipidus (HP:0009806)1.41111864
60Hypokalemic alkalosis (HP:0001949)1.40551273
61Absent rod-and cone-mediated responses on ERG (HP:0007688)1.36625217
62Preaxial hand polydactyly (HP:0001177)1.28509648
63Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.26979067
64Median cleft lip (HP:0000161)1.24814962
65Short thorax (HP:0010306)1.23866298
66Hyponatremia (HP:0002902)1.19980136
67Abnormality of the distal phalanges of the toes (HP:0010182)1.17995519
68Hand muscle atrophy (HP:0009130)1.17741592
69Glucose intolerance (HP:0000833)1.17192013
70Tubulointerstitial abnormality (HP:0001969)1.14115419
71Fetal akinesia sequence (HP:0001989)1.13944917
72Stage 5 chronic kidney disease (HP:0003774)1.13149261
73Bifid scrotum (HP:0000048)1.12286629
74Short femoral neck (HP:0100864)1.12141429
75Abnormal drinking behavior (HP:0030082)1.10949945
76Polydipsia (HP:0001959)1.10949945
77Poor coordination (HP:0002370)1.10670577
78Cone-rod dystrophy (HP:0000548)1.10488257
79Aplasia of the musculature (HP:0100854)1.10309142
80Abnormality of the dental root (HP:0006486)1.08732190
81Taurodontia (HP:0000679)1.08732190
82Abnormality of permanent molar morphology (HP:0011071)1.08732190
83Genital tract atresia (HP:0001827)1.07504980
84Vaginal atresia (HP:0000148)1.07435646
85Spinal muscular atrophy (HP:0007269)1.04200816
86Abnormality of the frontal sinuses (HP:0002687)1.04177389
87Bile duct proliferation (HP:0001408)1.01000554
88Abnormal biliary tract physiology (HP:0012439)1.01000554
89Short nail (HP:0001799)0.99240994
90Abnormality of the renal cortex (HP:0011035)0.99125672
91Abnormality of molar morphology (HP:0011070)0.98827133
92Abnormality of molar (HP:0011077)0.98827133
93Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)0.98662522
94Carpal bone hypoplasia (HP:0001498)0.98592026
95Aplasia/Hypoplasia involving the sinuses (HP:0009120)0.97575526
96Retinitis pigmentosa (HP:0000510)0.97273432
97Muscle fiber splitting (HP:0003555)0.97205746
98Popliteal pterygium (HP:0009756)0.97152746
99Abnormal rod and cone electroretinograms (HP:0008323)0.96992456
100Abnormality of the dental pulp (HP:0006479)0.95857466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.95981689
2EPHA24.81940367
3MAPKAPK32.79563923
4NME12.62352405
5MAP3K22.07457640
6STK242.03986369
7MAPK1511.7452563
8SMG11.94290629
9TTK1.87767656
10EEF2K1.53400077
11PTK2B1.53170442
12CSK1.41257936
13MAP3K31.41191312
14PNCK1.32523321
15TLK11.27041431
16LRRK21.18968244
17STK101.15384994
18NEK61.08925406
19TRPM71.03012524
20RIPK41.02609603
21BCR1.00417935
22CAMKK10.92925051
23MST1R0.92819111
24PRKCI0.89580224
25TBK10.88855344
26EPHB10.86528006
27GRK60.86481909
28MAP3K70.84346283
29MARK20.82496056
30BRSK20.77727191
31STK160.74144024
32EPHA30.72990374
33INSRR0.67115561
34CAMKK20.66551818
35ADRBK20.64823382
36WNK40.63919672
37ERBB20.63341065
38ERBB30.62919333
39GRK10.60962527
40PRKCQ0.55422080
41MAP3K120.54900427
42TESK10.53459151
43STK380.51859906
44PRKCD0.50274160
45CAMK2G0.48030109
46MAP2K20.47271541
47MAP3K40.44764391
48SGK10.44733827
49BMPR1B0.44676373
50RPS6KB20.44172453
51ADRBK10.42797191
52PRKAA20.42772774
53ZAP700.41140366
54AURKA0.40061085
55PASK0.39925286
56HIPK20.38685786
57ICK0.36274513
58OXSR10.33680781
59MAPKAPK50.33638580
60DYRK1B0.32462035
61MAP2K40.32247075
62MET0.30723352
63IRAK10.28468360
64MAP2K70.27801824
65CDK80.27461346
66PRKACA0.26999632
67PRKCA0.26750490
68ABL10.26601659
69PDPK10.25198243
70PLK10.24960934
71MAPK130.23608733
72MATK0.22930344
73NLK0.20354480
74CHEK20.20049036
75CDK190.19896057
76AKT20.19472555
77PTK60.19335745
78DYRK1A0.18383771
79FER0.18341442
80STK38L0.18255777
81TEC0.18158918
82LATS10.18157722
83PBK0.17698173
84ACVR1B0.17097589
85MAP2K60.17064399
86IGF1R0.16647579
87MAP2K10.16412375
88STK390.16408475
89CAMK2A0.15431968
90FYN0.15429664
91FGFR30.14364551
92EGFR0.12384747
93ROCK10.12354679
94FRK0.11957341
95MYLK0.11324383
96TRIB30.11085847
97SRC0.10658376
98PINK10.10625204
99ILK0.09929416
100ITK0.09867997

Predicted pathways (KEGG)

RankGene SetZ-score
1* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.11129018
2Chemical carcinogenesis_Homo sapiens_hsa052044.73829476
3Phenylalanine metabolism_Homo sapiens_hsa003604.64586393
4Histidine metabolism_Homo sapiens_hsa003404.57673638
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.46308298
6Tyrosine metabolism_Homo sapiens_hsa003503.75533708
7beta-Alanine metabolism_Homo sapiens_hsa004102.96522208
8Huntingtons disease_Homo sapiens_hsa050162.93858376
9Glutathione metabolism_Homo sapiens_hsa004802.72141974
10Caffeine metabolism_Homo sapiens_hsa002322.71314152
11Retinol metabolism_Homo sapiens_hsa008302.49297891
12Linoleic acid metabolism_Homo sapiens_hsa005912.33728138
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.22563974
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.16038011
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83701180
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78796767
17Sphingolipid metabolism_Homo sapiens_hsa006001.68988842
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.59514762
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53963955
20ABC transporters_Homo sapiens_hsa020101.50588610
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40303793
22Peroxisome_Homo sapiens_hsa041461.37819706
23Fatty acid degradation_Homo sapiens_hsa000711.31207366
24Tight junction_Homo sapiens_hsa045301.26004588
25Arachidonic acid metabolism_Homo sapiens_hsa005901.22265544
26Salivary secretion_Homo sapiens_hsa049701.14551737
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05526576
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04912170
29Starch and sucrose metabolism_Homo sapiens_hsa005000.96380364
30Drug metabolism - other enzymes_Homo sapiens_hsa009830.95807935
31Taste transduction_Homo sapiens_hsa047420.91820802
32Circadian rhythm_Homo sapiens_hsa047100.84001724
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80689669
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80117294
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78417699
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76397689
37Collecting duct acid secretion_Homo sapiens_hsa049660.75433169
38Olfactory transduction_Homo sapiens_hsa047400.74472357
39Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70554554
40Hematopoietic cell lineage_Homo sapiens_hsa046400.64136283
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.60563353
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59225248
43Nitrogen metabolism_Homo sapiens_hsa009100.59150186
44Phototransduction_Homo sapiens_hsa047440.58441380
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58433898
46Hepatitis C_Homo sapiens_hsa051600.57891690
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.56402406
48Choline metabolism in cancer_Homo sapiens_hsa052310.56343018
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.54196953
50Nicotine addiction_Homo sapiens_hsa050330.54098389
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.53043985
52Vitamin digestion and absorption_Homo sapiens_hsa049770.49995646
53Notch signaling pathway_Homo sapiens_hsa043300.45269866
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45003520
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.43574547
56Metabolic pathways_Homo sapiens_hsa011000.42422090
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37963381
58Hedgehog signaling pathway_Homo sapiens_hsa043400.37717303
59Glycerolipid metabolism_Homo sapiens_hsa005610.36822052
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36630401
61Tryptophan metabolism_Homo sapiens_hsa003800.36424209
62Serotonergic synapse_Homo sapiens_hsa047260.35727846
63Butanoate metabolism_Homo sapiens_hsa006500.35675406
64Asthma_Homo sapiens_hsa053100.35454049
65PPAR signaling pathway_Homo sapiens_hsa033200.34129706
66Complement and coagulation cascades_Homo sapiens_hsa046100.30441101
67Type I diabetes mellitus_Homo sapiens_hsa049400.30267072
68Allograft rejection_Homo sapiens_hsa053300.29782976
69Calcium signaling pathway_Homo sapiens_hsa040200.29733078
70Cocaine addiction_Homo sapiens_hsa050300.29471747
71Autoimmune thyroid disease_Homo sapiens_hsa053200.28996834
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28129306
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27213757
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.27020134
75Basal cell carcinoma_Homo sapiens_hsa052170.26018785
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24590935
77cAMP signaling pathway_Homo sapiens_hsa040240.23896298
78Regulation of autophagy_Homo sapiens_hsa041400.23451562
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23447973
80Fatty acid biosynthesis_Homo sapiens_hsa000610.23418285
81Graft-versus-host disease_Homo sapiens_hsa053320.22039857
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21995427
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19966327
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19765708
85Cardiac muscle contraction_Homo sapiens_hsa042600.18520446
86Purine metabolism_Homo sapiens_hsa002300.17517929
87Arginine and proline metabolism_Homo sapiens_hsa003300.16602498
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16508300
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.16455575
90Amoebiasis_Homo sapiens_hsa051460.15514507
91Amphetamine addiction_Homo sapiens_hsa050310.15016651
92Pancreatic secretion_Homo sapiens_hsa049720.13924313
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13292300
94Adherens junction_Homo sapiens_hsa045200.12429331
95Ovarian steroidogenesis_Homo sapiens_hsa049130.11198127
96Bile secretion_Homo sapiens_hsa049760.10583752
97Nucleotide excision repair_Homo sapiens_hsa034200.10079646
98Lysosome_Homo sapiens_hsa041420.08759162
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.08456446
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.07822267

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