ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	microtubule depolymerization (GO:0007019)	5.71083719
2	protein neddylation (GO:0045116)	4.48100537
3	oxygen transport (GO:0015671)	4.39775582
4	erythrocyte maturation (GO:0043249)	4.39618387
5	gas transport (GO:0015669)	4.25919468
6	diterpenoid biosynthetic process (GO:0016102)	4.07446521
7	thrombin receptor signaling pathway (GO:0070493)	4.05345524
8	DNA replication checkpoint (GO:0000076)	3.96732637
9	synapsis (GO:0007129)	3.94862893
10	neutrophil activation involved in immune response (GO:0002283)	3.86330520
11	terpenoid biosynthetic process (GO:0016114)	3.81880126
12	protoporphyrinogen IX metabolic process (GO:0046501)	3.78187977
13	COPI coating of Golgi vesicle (GO:0048205)	3.65706838
14	Golgi transport vesicle coating (GO:0048200)	3.65706838
15	DNA replication initiation (GO:0006270)	3.64785261
16	regulation of histone H3-K4 methylation (GO:0051569)	3.63548678
17	definitive hemopoiesis (GO:0060216)	3.57193018
18	meiotic chromosome segregation (GO:0045132)	3.52486714
19	mitochondrial DNA metabolic process (GO:0032042)	3.49744869
20	microtubule polymerization or depolymerization (GO:0031109)	3.48128004
21	platelet aggregation (GO:0070527)	3.45510317
22	negative regulation of histone methylation (GO:0031061)	3.44550093
23	erythrocyte development (GO:0048821)	3.41423419
24	vesicle targeting (GO:0006903)	3.40684080
25	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	3.32887375
26	myeloid cell development (GO:0061515)	3.32324769
27	proteasome assembly (GO:0043248)	3.31032660
28	poly(A)+ mRNA export from nucleus (GO:0016973)	3.28848994
29	megakaryocyte development (GO:0035855)	3.26490952
30	DNA synthesis involved in DNA repair (GO:0000731)	3.23975624
31	oxidative phosphorylation (GO:0006119)	3.21464668
32	proline biosynthetic process (GO:0006561)	3.20354588
33	positive regulation of granulocyte differentiation (GO:0030854)	3.17235884
34	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.11511306
35	mitochondrial DNA replication (GO:0006264)	3.11016478
36	regulation of Golgi to plasma membrane protein transport (GO:0042996)	3.09811163
37	mitotic sister chromatid segregation (GO:0000070)	3.08491294
38	platelet formation (GO:0030220)	3.06864725
39	regulation of histone H3-K27 methylation (GO:0061085)	3.06677393
40	tolerance induction (GO:0002507)	3.01856634
41	negative regulation of thymocyte apoptotic process (GO:0070244)	2.99112920
42	autophagic vacuole fusion (GO:0000046)	2.98215361
43	tRNA aminoacylation for protein translation (GO:0006418)	2.97116701
44	resolution of meiotic recombination intermediates (GO:0000712)	2.95146824
45	DNA methylation involved in gamete generation (GO:0043046)	2.94981884
46	DNA strand elongation involved in DNA replication (GO:0006271)	2.93763499
47	deoxyribose phosphate biosynthetic process (GO:0046385)	2.93379242
48	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.93379242
49	granulocyte differentiation (GO:0030851)	2.90925097
50	oxaloacetate metabolic process (GO:0006107)	2.90445114
51	telomere maintenance via semi-conservative replication (GO:0032201)	2.90263017
52	regulation of translational fidelity (GO:0006450)	2.89989413
53	regulation of platelet aggregation (GO:0090330)	2.88180995
54	regulation of oxidative phosphorylation (GO:0002082)	2.87214808
55	NADH metabolic process (GO:0006734)	2.86911927
56	RNA destabilization (GO:0050779)	2.86305306
57	mitotic nuclear envelope disassembly (GO:0007077)	2.86239744
58	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.86044023
59	DNA strand elongation (GO:0022616)	2.84942497
60	fatty acid elongation (GO:0030497)	2.84763190
61	nuclear pore complex assembly (GO:0051292)	2.84214125
62	chromosome organization involved in meiosis (GO:0070192)	2.83299643
63	tRNA aminoacylation (GO:0043039)	2.82297580
64	amino acid activation (GO:0043038)	2.82297580
65	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.82282272
66	regulation of integrin-mediated signaling pathway (GO:2001044)	2.82136583
67	regulation of histone H3-K9 methylation (GO:0051570)	2.78360381
68	nuclear pore organization (GO:0006999)	2.76476624
69	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.76385549
70	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.74863148
71	nuclear envelope disassembly (GO:0051081)	2.74323996
72	membrane disassembly (GO:0030397)	2.74323996
73	chromosome segregation (GO:0007059)	2.73268942
74	sister chromatid segregation (GO:0000819)	2.72363989
75	nucleoside diphosphate biosynthetic process (GO:0009133)	2.72253433
76	DNA catabolic process, exonucleolytic (GO:0000738)	2.70800117
77	fusion of sperm to egg plasma membrane (GO:0007342)	2.70156730
78	pentose metabolic process (GO:0019321)	2.69701888
79	meiosis I (GO:0007127)	2.69225751
80	folic acid-containing compound biosynthetic process (GO:0009396)	2.68458121
81	negative regulation of norepinephrine secretion (GO:0010700)	2.68281062
82	regulation of platelet activation (GO:0010543)	2.64720485
83	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.64543623
84	male meiosis (GO:0007140)	2.63611887
85	regulation of gene expression by genetic imprinting (GO:0006349)	2.62551847
86	tetrahydrofolate metabolic process (GO:0046653)	2.59724032
87	negative regulation of erythrocyte differentiation (GO:0045647)	2.59576623
88	regulation of histone methylation (GO:0031060)	2.58604304
89	homocysteine metabolic process (GO:0050667)	2.58109904
90	regulation of RNA export from nucleus (GO:0046831)	2.57646822
91	blood coagulation, intrinsic pathway (GO:0007597)	2.57474986
92	regulation of early endosome to late endosome transport (GO:2000641)	2.57194914
93	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.56395749
94	neutrophil activation (GO:0042119)	2.54957607
95	positive regulation of B cell differentiation (GO:0045579)	2.54124836
96	pentose-phosphate shunt (GO:0006098)	2.51646730
97	regulation of megakaryocyte differentiation (GO:0045652)	2.51396470
98	S-adenosylmethionine metabolic process (GO:0046500)	2.48672992
99	formation of translation preinitiation complex (GO:0001731)	2.48193534
100	adenosine receptor signaling pathway (GO:0001973)	2.47326211

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.28027461
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.32521829
3	GATA1_19941826_ChIP-Seq_K562_Human	3.21564297
4	NCOR1_26117541_ChIP-Seq_K562_Human	3.18334125
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.97249526
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.77150819
7	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.55918100
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.49794843
9	SCL_19346495_ChIP-Seq_HPC-7_Human	2.47315888
10	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.46872164
11	GATA2_19941826_ChIP-Seq_K562_Human	2.46089264
12	GATA1_22025678_ChIP-Seq_K562_Human	2.42500712
13	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.20751121
14	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.12271315
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.10765412
16	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.07575422
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.06436791
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.05112357
19	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.03027663
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.01606296
21	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.97543951
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.97324809
23	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.96413161
24	DCP1A_22483619_ChIP-Seq_HELA_Human	1.93140651
25	SPI1_23127762_ChIP-Seq_K562_Human	1.92411024
26	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.91401796
27	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.90888493
28	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.85283078
29	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.81647402
30	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.80006865
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.78981099
32	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.76005679
33	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.75276181
34	ZNF263_19887448_ChIP-Seq_K562_Human	1.73191355
35	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.71063970
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.70188736
37	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.70033355
38	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.66042939
39	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.60503013
40	KDM5A_27292631_Chip-Seq_BREAST_Human	1.60422980
41	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.60260915
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.59076284
43	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.57039467
44	XRN2_22483619_ChIP-Seq_HELA_Human	1.54470764
45	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53725051
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52118162
47	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50515772
48	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.47705360
49	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.46074510
50	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.43501829
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.43309778
52	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.43169663
53	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.42389134
54	VDR_23849224_ChIP-Seq_CD4+_Human	1.41778241
55	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.41058341
56	TFEB_21752829_ChIP-Seq_HELA_Human	1.40798070
57	ELK1_19687146_ChIP-ChIP_HELA_Human	1.40292496
58	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.40127120
59	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.39817606
60	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38630362
61	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.34162664
62	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.32965809
63	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.30176797
64	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.29961324
65	MYC_22102868_ChIP-Seq_BL_Human	1.29394532
66	CIITA_25753668_ChIP-Seq_RAJI_Human	1.27201947
67	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.26552925
68	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.26002173
69	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.24200337
70	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.21048931
71	TTF2_22483619_ChIP-Seq_HELA_Human	1.20032437
72	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.15723788
73	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.15388078
74	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.14105625
75	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.11254318
76	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.11094944
77	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.10684206
78	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.08875282
79	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.08221570
80	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.08035717
81	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.07475871
82	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.07336440
83	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05524365
84	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.04807253
85	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.04794362
86	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.04368757
87	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.03882755
88	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.03710601
89	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.03332762
90	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.01165510
91	SPI1_23547873_ChIP-Seq_NB4_Human	1.00963554
92	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.99843938
93	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.99525923
94	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98566472
95	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.97514290
96	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.96445146
97	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.92236397
98	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.91348717
99	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.88772866
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.88072844

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	5.83253561
2	MP0004147_increased_porphyrin_level	3.83832491
3	MP0005083_abnormal_biliary_tract	3.61550703
4	MP0004957_abnormal_blastocyst_morpholog	3.55466888
5	MP0003656_abnormal_erythrocyte_physiolo	3.40332836
6	MP0003111_abnormal_nucleus_morphology	3.15750149
7	MP0008995_early_reproductive_senescence	2.82390126
8	MP0008058_abnormal_DNA_repair	2.76888365
9	MP0009697_abnormal_copulation	2.63942989
10	MP0006035_abnormal_mitochondrial_morpho	2.61239335
11	MP0002132_abnormal_respiratory_system	2.59599717
12	MP0008004_abnormal_stomach_pH	2.57964036
13	MP0008932_abnormal_embryonic_tissue	2.57754559
14	MP0006036_abnormal_mitochondrial_physio	2.44438253
15	MP0005410_abnormal_fertilization	2.34040597
16	MP0003718_maternal_effect	2.27293299
17	MP0010094_abnormal_chromosome_stability	2.20025752
18	MP0001545_abnormal_hematopoietic_system	2.18595194
19	MP0005397_hematopoietic_system_phenotyp	2.18595194
20	MP0000015_abnormal_ear_pigmentation	1.96623681
21	MP0005451_abnormal_body_composition	1.95378843
22	MP0001661_extended_life_span	1.92930164
23	MP0000465_gastrointestinal_hemorrhage	1.89560752
24	MP0000678_abnormal_parathyroid_gland	1.85048020
25	MP0008775_abnormal_heart_ventricle	1.75800578
26	MP0003077_abnormal_cell_cycle	1.71896487
27	MP0005084_abnormal_gallbladder_morpholo	1.71862317
28	MP0003786_premature_aging	1.69371554
29	MP0000358_abnormal_cell_content/	1.65915583
30	MP0004084_abnormal_cardiac_muscle	1.57895403
31	MP0008007_abnormal_cellular_replicative	1.57561016
32	MP0003693_abnormal_embryo_hatching	1.54937000
33	MP0001730_embryonic_growth_arrest	1.53996229
34	MP0001929_abnormal_gametogenesis	1.50107322
35	MP0003186_abnormal_redox_activity	1.47577518
36	MP0002210_abnormal_sex_determination	1.36603181
37	MP0004145_abnormal_muscle_electrophysio	1.27951602
38	MP0003698_abnormal_male_reproductive	1.27056879
39	MP0005636_abnormal_mineral_homeostasis	1.25987301
40	MP0002398_abnormal_bone_marrow	1.23758889
41	MP0001697_abnormal_embryo_size	1.19638562
42	MP0003806_abnormal_nucleotide_metabolis	1.18988437
43	MP0002080_prenatal_lethality	1.17940192
44	MP0000703_abnormal_thymus_morphology	1.16124901
45	MP0000313_abnormal_cell_death	1.15404341
46	MP0008872_abnormal_physiological_respon	1.14710330
47	MP0004036_abnormal_muscle_relaxation	1.12813544
48	MP0002086_abnormal_extraembryonic_tissu	1.11610905
49	MP0002722_abnormal_immune_system	1.11299262
50	MP0009278_abnormal_bone_marrow	1.10323127
51	MP0008057_abnormal_DNA_replication	1.04966558
52	MP0002019_abnormal_tumor_incidence	1.04946513
53	MP0000689_abnormal_spleen_morphology	1.04748341
54	MP0004233_abnormal_muscle_weight	1.01179782
55	MP0001727_abnormal_embryo_implantation	1.00920717
56	MP0008877_abnormal_DNA_methylation	0.98751217
57	MP0000350_abnormal_cell_proliferation	0.98630397
58	MP0009333_abnormal_splenocyte_physiolog	0.97614463
59	MP0003221_abnormal_cardiomyocyte_apopto	0.95519077
60	MP0000343_altered_response_to	0.95330768
61	MP0005384_cellular_phenotype	0.94965968
62	MP0001544_abnormal_cardiovascular_syste	0.94289788
63	MP0005385_cardiovascular_system_phenoty	0.94289788
64	MP0001672_abnormal_embryogenesis/_devel	0.91606222
65	MP0005380_embryogenesis_phenotype	0.91606222
66	MP0004510_myositis	0.90778576
67	MP0002429_abnormal_blood_cell	0.90688246
68	MP0004947_skin_inflammation	0.90518914
69	MP0000372_irregular_coat_pigmentation	0.89807242
70	MP0005670_abnormal_white_adipose	0.88838934
71	MP0008260_abnormal_autophagy	0.88429815
72	MP0001145_abnormal_male_reproductive	0.87661727
73	MP0000653_abnormal_sex_gland	0.87327456
74	MP0005621_abnormal_cell_physiology	0.86994925
75	MP0004130_abnormal_muscle_cell	0.86357541
76	MP0005501_abnormal_skin_physiology	0.86309884
77	MP0003984_embryonic_growth_retardation	0.83273697
78	MP0002161_abnormal_fertility/fecundity	0.82088166
79	MP0002877_abnormal_melanocyte_morpholog	0.81204311
80	MP0000598_abnormal_liver_morphology	0.79485416
81	MP0002088_abnormal_embryonic_growth/wei	0.78801091
82	MP0004808_abnormal_hematopoietic_stem	0.78286070
83	MP0002736_abnormal_nociception_after	0.77148792
84	MP0005058_abnormal_lysosome_morphology	0.76921521
85	MP0005666_abnormal_adipose_tissue	0.75340605
86	MP0009931_abnormal_skin_appearance	0.75297384
87	MP0000230_abnormal_systemic_arterial	0.73370205
88	MP0009763_increased_sensitivity_to	0.72599831
89	MP0001851_eye_inflammation	0.70064204
90	MP0004085_abnormal_heartbeat	0.69634610
91	MP0003699_abnormal_female_reproductive	0.68482841
92	MP0003566_abnormal_cell_adhesion	0.66917311
93	MP0005535_abnormal_body_temperature	0.66880011
94	MP0001853_heart_inflammation	0.64929325
95	MP0003724_increased_susceptibility_to	0.64371427
96	MP0006276_abnormal_autonomic_nervous	0.63848909
97	MP0010352_gastrointestinal_tract_polyps	0.62345225
98	MP0009642_abnormal_blood_homeostasis	0.61671307
99	MP0008770_decreased_survivor_rate	0.61463422
100	MP0003638_abnormal_response/metabolism_	0.59732257

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal gallbladder physiology (HP:0012438)	7.37930211
2	Cholecystitis (HP:0001082)	7.37930211
3	Prolonged bleeding time (HP:0003010)	6.81768377
4	Petechiae (HP:0000967)	6.00702339
5	Menorrhagia (HP:0000132)	5.78342720
6	Increased mean platelet volume (HP:0011877)	5.46492218
7	Abnormality of the heme biosynthetic pathway (HP:0010472)	5.13840612
8	Abnormal platelet volume (HP:0011876)	5.04314245
9	Reticulocytosis (HP:0001923)	4.86296754
10	Truncus arteriosus (HP:0001660)	4.83687568
11	Poikilocytosis (HP:0004447)	4.80881342
12	Upper limb muscle weakness (HP:0003484)	4.66357148
13	Hyperthyroidism (HP:0000836)	4.53646767
14	Abnormal platelet function (HP:0011869)	4.29120574
15	Impaired platelet aggregation (HP:0003540)	4.29120574
16	Polycythemia (HP:0001901)	4.24979284
17	Epistaxis (HP:0000421)	4.12450772
18	Acanthocytosis (HP:0001927)	3.99304641
19	Purpura (HP:0000979)	3.96064925
20	Cholelithiasis (HP:0001081)	3.46388059
21	Ileus (HP:0002595)	3.32308918
22	Abnormal hemoglobin (HP:0011902)	3.27257853
23	Abnormality of reticulocytes (HP:0004312)	3.24270030
24	Abnormal large intestine physiology (HP:0012700)	3.18052099
25	Tinnitus (HP:0000360)	3.10634150
26	Abnormal gallbladder morphology (HP:0012437)	3.10139979
27	Seborrheic dermatitis (HP:0001051)	3.09312440
28	Ankyloglossia (HP:0010296)	3.05472085
29	Bowel incontinence (HP:0002607)	3.04971057
30	Paralysis (HP:0003470)	3.00272649
31	Birth length less than 3rd percentile (HP:0003561)	2.98313731
32	Gingival bleeding (HP:0000225)	2.97254239
33	Male infertility (HP:0003251)	2.95393493
34	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.83477833
35	Hyperlipoproteinemia (HP:0010980)	2.80869397
36	Cortical dysplasia (HP:0002539)	2.79413321
37	Hypertensive crisis (HP:0100735)	2.74484886
38	Abnormality of homocysteine metabolism (HP:0010919)	2.70398578
39	Homocystinuria (HP:0002156)	2.70398578
40	Abnormal pupillary function (HP:0007686)	2.62814443
41	Abnormality of lateral ventricle (HP:0030047)	2.58580520
42	Abnormality of glycolysis (HP:0004366)	2.58321323
43	Orthostatic hypotension (HP:0001278)	2.49127966
44	Dyschromatopsia (HP:0007641)	2.47202503
45	Increased serum pyruvate (HP:0003542)	2.44842922
46	Nausea (HP:0002018)	2.44106078
47	Abnormality of the gallbladder (HP:0005264)	2.40549715
48	Ventricular fibrillation (HP:0001663)	2.38744699
49	Breast hypoplasia (HP:0003187)	2.28393726
50	Abnormality of oral frenula (HP:0000190)	2.25525913
51	Hypoparathyroidism (HP:0000829)	2.25235136
52	Abnormality of the tricuspid valve (HP:0001702)	2.21188967
53	Gastrointestinal dysmotility (HP:0002579)	2.20155223
54	Atelectasis (HP:0100750)	2.13533933
55	Progressive external ophthalmoplegia (HP:0000590)	2.12688259
56	Hyperbilirubinemia (HP:0002904)	2.08346308
57	Myelodysplasia (HP:0002863)	2.06592492
58	Autoamputation (HP:0001218)	2.05222334
59	Papillary thyroid carcinoma (HP:0002895)	2.03882009
60	Insidious onset (HP:0003587)	2.02992694
61	Termporal pattern (HP:0011008)	2.02992694
62	Abnormal spermatogenesis (HP:0008669)	2.02145204
63	Abnormality of the common coagulation pathway (HP:0010990)	1.99179249
64	Thyroid carcinoma (HP:0002890)	1.96221298
65	Episodic fever (HP:0001954)	1.88884531
66	Increased serum ferritin (HP:0003281)	1.87373190
67	Abnormality of the anterior horn cell (HP:0006802)	1.86785327
68	Degeneration of anterior horn cells (HP:0002398)	1.86785327
69	Cerebral hemorrhage (HP:0001342)	1.84454256
70	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.84296127
71	Short middle phalanx of the 5th finger (HP:0004220)	1.82646523
72	Abnormally folded helix (HP:0008544)	1.81834390
73	Neuroendocrine neoplasm (HP:0100634)	1.81772490
74	Abnormality of cochlea (HP:0000375)	1.80923602
75	Acute myeloid leukemia (HP:0004808)	1.80253845
76	Easy fatigability (HP:0003388)	1.78840479
77	Multiple enchondromatosis (HP:0005701)	1.78556202
78	Abnormality of iron homeostasis (HP:0011031)	1.77199566
79	Peripheral hypomyelination (HP:0007182)	1.75551231
80	Spontaneous abortion (HP:0005268)	1.70350431
81	Spontaneous hematomas (HP:0007420)	1.69503067
82	Dysautonomia (HP:0002459)	1.67014750
83	Abnormality of transition element cation homeostasis (HP:0011030)	1.64445260
84	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.64170448
85	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.63864245
86	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.63864245
87	Generalized aminoaciduria (HP:0002909)	1.63448410
88	Bruising susceptibility (HP:0000978)	1.62358277
89	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.60106388
90	Cerebral hypomyelination (HP:0006808)	1.58845210
91	Hepatosplenomegaly (HP:0001433)	1.55115702
92	Postnatal microcephaly (HP:0005484)	1.54485449
93	Flat cornea (HP:0007720)	1.52205826
94	Central scotoma (HP:0000603)	1.50773794
95	Obstructive lung disease (HP:0006536)	1.47961307
96	Chronic obstructive pulmonary disease (HP:0006510)	1.47961307
97	Fatigue (HP:0012378)	1.47492451
98	Delayed puberty (HP:0000823)	1.47022172
99	Acute encephalopathy (HP:0006846)	1.46880507
100	Morphological abnormality of the inner ear (HP:0011390)	1.46076320

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	6.10359447
2	RIPK4	5.07957731
3	MST4	4.82591592
4	BMX	3.42740816
5	KSR2	2.32424147
6	BUB1	2.25999095
7	MAP3K2	2.21800862
8	TTK	2.03569830
9	MYLK	2.00477592
10	BMPR2	1.85575008
11	MAPKAPK3	1.82156194
12	PLK4	1.80226063
13	BRSK2	1.54622806
14	CCNB1	1.50848235
15	RAF1	1.49703328
16	CLK1	1.42585240
17	STK3	1.42190205
18	TESK2	1.40373490
19	MAP3K4	1.39839089
20	BTK	1.39364208
21	NTRK3	1.31361330
22	GRK6	1.30592888
23	PTK2B	1.30578281
24	MAP3K6	1.28982775
25	ILK	1.28146860
26	TEC	1.28067021
27	RET	1.25108834
28	EEF2K	1.24070502
29	PAK1	1.18695771
30	ZAP70	1.18113875
31	SIK3	1.15019957
32	PLK2	1.13110349
33	SCYL2	1.07626249
34	NME1	1.07251842
35	MAP3K8	1.06110505
36	MAP2K7	1.02509808
37	IRAK3	0.99767647
38	KSR1	0.98284873
39	SYK	0.97595431
40	NUAK1	0.93719093
41	STK16	0.89926137
42	BRD4	0.88952890
43	PKN1	0.87502841
44	TAOK3	0.86947399
45	WNK4	0.86526327
46	MATK	0.86469862
47	MAP2K1	0.85534658
48	PIK3CG	0.85389112
49	RPS6KA4	0.80552520
50	PDK2	0.80527618
51	TRIM28	0.79784417
52	PINK1	0.79762925
53	SRPK1	0.78537157
54	BLK	0.78272616
55	JAK2	0.78000199
56	PLK3	0.76990729
57	AURKA	0.72029757
58	DAPK1	0.70442733
59	STK4	0.68537254
60	BCR	0.67145368
61	STK10	0.67011933
62	AKT3	0.66330830
63	NEK2	0.65894262
64	TAOK2	0.64694301
65	ATR	0.63132478
66	CDK12	0.60968501
67	CSNK1G3	0.59946436
68	DAPK3	0.54373188
69	EIF2AK3	0.53183163
70	NEK1	0.53035623
71	PIM1	0.51748535
72	PBK	0.51488112
73	BRSK1	0.48546121
74	PRKD1	0.48042076
75	DYRK3	0.47997387
76	PKN2	0.47605380
77	PLK1	0.46012609
78	CAMKK2	0.45996918
79	CSNK1A1L	0.45834733
80	CDK1	0.45812329
81	CHEK1	0.45795826
82	TESK1	0.44075651
83	CHEK2	0.43907137
84	PRKACG	0.43327451
85	HCK	0.39469933
86	ICK	0.37878577
87	TRPM7	0.37718759
88	PAK2	0.37270695
89	INSRR	0.36999578
90	JAK3	0.36472253
91	CDK2	0.34355164
92	LYN	0.34352312
93	RPS6KB2	0.34208463
94	CDC7	0.33491414
95	MAPKAPK5	0.33140125
96	CDK7	0.32621375
97	IKBKB	0.31478562
98	CAMK1	0.30766435
99	ATM	0.30701281
100	CSNK1E	0.30326583

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.82037462
2	Mismatch repair_Homo sapiens_hsa03430	3.63348663
3	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.32587974
4	One carbon pool by folate_Homo sapiens_hsa00670	3.12517739
5	DNA replication_Homo sapiens_hsa03030	2.76410421
6	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.49646805
7	Platelet activation_Homo sapiens_hsa04611	2.26209228
8	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.17062371
9	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.04086676
10	Homologous recombination_Homo sapiens_hsa03440	2.03803702
11	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.00560089
12	Pentose phosphate pathway_Homo sapiens_hsa00030	1.95813473
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.91835765
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.76746440
15	RNA transport_Homo sapiens_hsa03013	1.74669117
16	Basal transcription factors_Homo sapiens_hsa03022	1.73975515
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.67005665
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.59115551
19	Cell cycle_Homo sapiens_hsa04110	1.59099876
20	Carbon metabolism_Homo sapiens_hsa01200	1.58521037
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.51117639
22	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.49483689
23	RNA polymerase_Homo sapiens_hsa03020	1.47460762
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43366453
25	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.41687297
26	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.41555386
27	Sulfur metabolism_Homo sapiens_hsa00920	1.40852017
28	Fatty acid elongation_Homo sapiens_hsa00062	1.40197537
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.34455539
30	Thyroid cancer_Homo sapiens_hsa05216	1.32606886
31	Parkinsons disease_Homo sapiens_hsa05012	1.29960057
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29950613
33	Acute myeloid leukemia_Homo sapiens_hsa05221	1.24067077
34	Spliceosome_Homo sapiens_hsa03040	1.21757203
35	Shigellosis_Homo sapiens_hsa05131	1.21133140
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.19705116
37	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.15344792
38	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.08549308
39	Type II diabetes mellitus_Homo sapiens_hsa04930	1.05929235
40	Purine metabolism_Homo sapiens_hsa00230	1.05371163
41	Oocyte meiosis_Homo sapiens_hsa04114	1.03116072
42	Viral carcinogenesis_Homo sapiens_hsa05203	1.03085049
43	Non-homologous end-joining_Homo sapiens_hsa03450	1.02059223
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97223759
45	Proteasome_Homo sapiens_hsa03050	0.96563379
46	RNA degradation_Homo sapiens_hsa03018	0.96211739
47	Oxidative phosphorylation_Homo sapiens_hsa00190	0.92693710
48	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.91410922
49	Galactose metabolism_Homo sapiens_hsa00052	0.89830797
50	mRNA surveillance pathway_Homo sapiens_hsa03015	0.84946682
51	Renal cell carcinoma_Homo sapiens_hsa05211	0.84320185
52	Olfactory transduction_Homo sapiens_hsa04740	0.83906897
53	Insulin signaling pathway_Homo sapiens_hsa04910	0.82433642
54	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.81557797
55	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.81516327
56	mTOR signaling pathway_Homo sapiens_hsa04150	0.80726289
57	Non-small cell lung cancer_Homo sapiens_hsa05223	0.79870972
58	Huntingtons disease_Homo sapiens_hsa05016	0.78506651
59	Vibrio cholerae infection_Homo sapiens_hsa05110	0.76308310
60	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.74462547
61	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.74187938
62	Glutathione metabolism_Homo sapiens_hsa00480	0.73565974
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70830454
64	Base excision repair_Homo sapiens_hsa03410	0.70369340
65	Butanoate metabolism_Homo sapiens_hsa00650	0.70263671
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70249345
67	Pancreatic cancer_Homo sapiens_hsa05212	0.67996182
68	Gap junction_Homo sapiens_hsa04540	0.66449753
69	ErbB signaling pathway_Homo sapiens_hsa04012	0.65326458
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63107929
71	Endometrial cancer_Homo sapiens_hsa05213	0.61055373
72	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.60998074
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60295154
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.57123427
75	Choline metabolism in cancer_Homo sapiens_hsa05231	0.53227057
76	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.52305192
77	VEGF signaling pathway_Homo sapiens_hsa04370	0.50133807
78	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46793415
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46660584
80	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.46050083
81	Alcoholism_Homo sapiens_hsa05034	0.44364935
82	Metabolic pathways_Homo sapiens_hsa01100	0.43523581
83	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.43292090
84	Glioma_Homo sapiens_hsa05214	0.42420685
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41390059
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40996511
87	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.40938948
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.39717097
89	Endocytosis_Homo sapiens_hsa04144	0.38815792
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37669833
91	Prostate cancer_Homo sapiens_hsa05215	0.35438422
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31645962
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.29059202
94	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.27937334
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.26372552
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26117218
97	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.26064563
98	Apoptosis_Homo sapiens_hsa04210	0.25574906
99	Chemokine signaling pathway_Homo sapiens_hsa04062	0.25258634
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.23135649

CYP2F2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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