CYP2F2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microtubule depolymerization (GO:0007019)5.71083719
2protein neddylation (GO:0045116)4.48100537
3oxygen transport (GO:0015671)4.39775582
4erythrocyte maturation (GO:0043249)4.39618387
5gas transport (GO:0015669)4.25919468
6diterpenoid biosynthetic process (GO:0016102)4.07446521
7thrombin receptor signaling pathway (GO:0070493)4.05345524
8DNA replication checkpoint (GO:0000076)3.96732637
9synapsis (GO:0007129)3.94862893
10neutrophil activation involved in immune response (GO:0002283)3.86330520
11terpenoid biosynthetic process (GO:0016114)3.81880126
12protoporphyrinogen IX metabolic process (GO:0046501)3.78187977
13Golgi transport vesicle coating (GO:0048200)3.65706838
14COPI coating of Golgi vesicle (GO:0048205)3.65706838
15DNA replication initiation (GO:0006270)3.64785261
16regulation of histone H3-K4 methylation (GO:0051569)3.63548678
17definitive hemopoiesis (GO:0060216)3.57193018
18meiotic chromosome segregation (GO:0045132)3.52486714
19mitochondrial DNA metabolic process (GO:0032042)3.49744869
20microtubule polymerization or depolymerization (GO:0031109)3.48128004
21platelet aggregation (GO:0070527)3.45510317
22negative regulation of histone methylation (GO:0031061)3.44550093
23erythrocyte development (GO:0048821)3.41423419
24vesicle targeting (GO:0006903)3.40684080
25G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.32887375
26myeloid cell development (GO:0061515)3.32324769
27proteasome assembly (GO:0043248)3.31032660
28poly(A)+ mRNA export from nucleus (GO:0016973)3.28848994
29megakaryocyte development (GO:0035855)3.26490952
30DNA synthesis involved in DNA repair (GO:0000731)3.23975624
31oxidative phosphorylation (GO:0006119)3.21464668
32proline biosynthetic process (GO:0006561)3.20354588
33positive regulation of granulocyte differentiation (GO:0030854)3.17235884
34pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.11511306
35mitochondrial DNA replication (GO:0006264)3.11016478
36regulation of Golgi to plasma membrane protein transport (GO:0042996)3.09811163
37mitotic sister chromatid segregation (GO:0000070)3.08491294
38platelet formation (GO:0030220)3.06864725
39regulation of histone H3-K27 methylation (GO:0061085)3.06677393
40tolerance induction (GO:0002507)3.01856634
41negative regulation of thymocyte apoptotic process (GO:0070244)2.99112920
42autophagic vacuole fusion (GO:0000046)2.98215361
43tRNA aminoacylation for protein translation (GO:0006418)2.97116701
44resolution of meiotic recombination intermediates (GO:0000712)2.95146824
45DNA methylation involved in gamete generation (GO:0043046)2.94981884
46DNA strand elongation involved in DNA replication (GO:0006271)2.93763499
472-deoxyribonucleotide biosynthetic process (GO:0009265)2.93379242
48deoxyribose phosphate biosynthetic process (GO:0046385)2.93379242
49granulocyte differentiation (GO:0030851)2.90925097
50oxaloacetate metabolic process (GO:0006107)2.90445114
51telomere maintenance via semi-conservative replication (GO:0032201)2.90263017
52regulation of translational fidelity (GO:0006450)2.89989413
53regulation of platelet aggregation (GO:0090330)2.88180995
54regulation of oxidative phosphorylation (GO:0002082)2.87214808
55NADH metabolic process (GO:0006734)2.86911927
56RNA destabilization (GO:0050779)2.86305306
57mitotic nuclear envelope disassembly (GO:0007077)2.86239744
58deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86044023
59DNA strand elongation (GO:0022616)2.84942497
60fatty acid elongation (GO:0030497)2.84763190
61nuclear pore complex assembly (GO:0051292)2.84214125
62chromosome organization involved in meiosis (GO:0070192)2.83299643
63amino acid activation (GO:0043038)2.82297580
64tRNA aminoacylation (GO:0043039)2.82297580
65Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82282272
66regulation of integrin-mediated signaling pathway (GO:2001044)2.82136583
67regulation of histone H3-K9 methylation (GO:0051570)2.78360381
68nuclear pore organization (GO:0006999)2.76476624
69positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.76385549
70misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.74863148
71membrane disassembly (GO:0030397)2.74323996
72nuclear envelope disassembly (GO:0051081)2.74323996
73chromosome segregation (GO:0007059)2.73268942
74sister chromatid segregation (GO:0000819)2.72363989
75nucleoside diphosphate biosynthetic process (GO:0009133)2.72253433
76DNA catabolic process, exonucleolytic (GO:0000738)2.70800117
77fusion of sperm to egg plasma membrane (GO:0007342)2.70156730
78pentose metabolic process (GO:0019321)2.69701888
79meiosis I (GO:0007127)2.69225751
80folic acid-containing compound biosynthetic process (GO:0009396)2.68458121
81negative regulation of norepinephrine secretion (GO:0010700)2.68281062
82regulation of platelet activation (GO:0010543)2.64720485
83purinergic nucleotide receptor signaling pathway (GO:0035590)2.64543623
84male meiosis (GO:0007140)2.63611887
85regulation of gene expression by genetic imprinting (GO:0006349)2.62551847
86tetrahydrofolate metabolic process (GO:0046653)2.59724032
87negative regulation of erythrocyte differentiation (GO:0045647)2.59576623
88regulation of histone methylation (GO:0031060)2.58604304
89homocysteine metabolic process (GO:0050667)2.58109904
90regulation of RNA export from nucleus (GO:0046831)2.57646822
91blood coagulation, intrinsic pathway (GO:0007597)2.57474986
92regulation of early endosome to late endosome transport (GO:2000641)2.57194914
93protoporphyrinogen IX biosynthetic process (GO:0006782)2.56395749
94neutrophil activation (GO:0042119)2.54957607
95positive regulation of B cell differentiation (GO:0045579)2.54124836
96pentose-phosphate shunt (GO:0006098)2.51646730
97regulation of megakaryocyte differentiation (GO:0045652)2.51396470
98S-adenosylmethionine metabolic process (GO:0046500)2.48672992
99formation of translation preinitiation complex (GO:0001731)2.48193534
100adenosine receptor signaling pathway (GO:0001973)2.47326211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.28027461
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32521829
3GATA1_19941826_ChIP-Seq_K562_Human3.21564297
4NCOR1_26117541_ChIP-Seq_K562_Human3.18334125
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.97249526
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77150819
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.55918100
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49794843
9SCL_19346495_ChIP-Seq_HPC-7_Human2.47315888
10THAP11_20581084_ChIP-Seq_MESCs_Mouse2.46872164
11GATA2_19941826_ChIP-Seq_K562_Human2.46089264
12GATA1_22025678_ChIP-Seq_K562_Human2.42500712
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.20751121
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12271315
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10765412
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07575422
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.06436791
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05112357
19SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.03027663
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.01606296
21HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97543951
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.97324809
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.96413161
24DCP1A_22483619_ChIP-Seq_HELA_Human1.93140651
25SPI1_23127762_ChIP-Seq_K562_Human1.92411024
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91401796
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90888493
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85283078
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81647402
30GATA1_22383799_ChIP-Seq_G1ME_Mouse1.80006865
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78981099
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76005679
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.75276181
34ZNF263_19887448_ChIP-Seq_K562_Human1.73191355
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71063970
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.70188736
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70033355
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66042939
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60503013
40KDM5A_27292631_Chip-Seq_BREAST_Human1.60422980
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60260915
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59076284
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.57039467
44XRN2_22483619_ChIP-Seq_HELA_Human1.54470764
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53725051
46FOXP3_21729870_ChIP-Seq_TREG_Human1.52118162
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50515772
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47705360
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46074510
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43501829
51GABP_19822575_ChIP-Seq_HepG2_Human1.43309778
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43169663
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42389134
54VDR_23849224_ChIP-Seq_CD4+_Human1.41778241
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41058341
56TFEB_21752829_ChIP-Seq_HELA_Human1.40798070
57ELK1_19687146_ChIP-ChIP_HELA_Human1.40292496
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40127120
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39817606
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38630362
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34162664
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32965809
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30176797
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29961324
65MYC_22102868_ChIP-Seq_BL_Human1.29394532
66CIITA_25753668_ChIP-Seq_RAJI_Human1.27201947
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26552925
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26002173
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24200337
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.21048931
71TTF2_22483619_ChIP-Seq_HELA_Human1.20032437
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15723788
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.15388078
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14105625
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11254318
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11094944
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10684206
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08875282
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08221570
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08035717
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07475871
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07336440
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05524365
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04807253
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04794362
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04368757
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03882755
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.03710601
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.03332762
90TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01165510
91SPI1_23547873_ChIP-Seq_NB4_Human1.00963554
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99843938
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99525923
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98566472
95ETS1_22383799_ChIP-Seq_G1ME_Mouse0.97514290
96KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96445146
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92236397
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91348717
99YY1_21170310_ChIP-Seq_MESCs_Mouse0.88772866
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88072844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.83253561
2MP0004147_increased_porphyrin_level3.83832491
3MP0005083_abnormal_biliary_tract3.61550703
4MP0004957_abnormal_blastocyst_morpholog3.55466888
5MP0003656_abnormal_erythrocyte_physiolo3.40332836
6MP0003111_abnormal_nucleus_morphology3.15750149
7MP0008995_early_reproductive_senescence2.82390126
8MP0008058_abnormal_DNA_repair2.76888365
9MP0009697_abnormal_copulation2.63942989
10MP0006035_abnormal_mitochondrial_morpho2.61239335
11MP0002132_abnormal_respiratory_system2.59599717
12MP0008004_abnormal_stomach_pH2.57964036
13MP0008932_abnormal_embryonic_tissue2.57754559
14MP0006036_abnormal_mitochondrial_physio2.44438253
15MP0005410_abnormal_fertilization2.34040597
16MP0003718_maternal_effect2.27293299
17MP0010094_abnormal_chromosome_stability2.20025752
18MP0005397_hematopoietic_system_phenotyp2.18595194
19MP0001545_abnormal_hematopoietic_system2.18595194
20MP0000015_abnormal_ear_pigmentation1.96623681
21MP0005451_abnormal_body_composition1.95378843
22MP0001661_extended_life_span1.92930164
23MP0000465_gastrointestinal_hemorrhage1.89560752
24MP0000678_abnormal_parathyroid_gland1.85048020
25MP0008775_abnormal_heart_ventricle1.75800578
26MP0003077_abnormal_cell_cycle1.71896487
27MP0005084_abnormal_gallbladder_morpholo1.71862317
28MP0003786_premature_aging1.69371554
29MP0000358_abnormal_cell_content/1.65915583
30MP0004084_abnormal_cardiac_muscle1.57895403
31MP0008007_abnormal_cellular_replicative1.57561016
32MP0003693_abnormal_embryo_hatching1.54937000
33MP0001730_embryonic_growth_arrest1.53996229
34MP0001929_abnormal_gametogenesis1.50107322
35MP0003186_abnormal_redox_activity1.47577518
36MP0002210_abnormal_sex_determination1.36603181
37MP0004145_abnormal_muscle_electrophysio1.27951602
38MP0003698_abnormal_male_reproductive1.27056879
39MP0005636_abnormal_mineral_homeostasis1.25987301
40MP0002398_abnormal_bone_marrow1.23758889
41MP0001697_abnormal_embryo_size1.19638562
42MP0003806_abnormal_nucleotide_metabolis1.18988437
43MP0002080_prenatal_lethality1.17940192
44MP0000703_abnormal_thymus_morphology1.16124901
45MP0000313_abnormal_cell_death1.15404341
46MP0008872_abnormal_physiological_respon1.14710330
47MP0004036_abnormal_muscle_relaxation1.12813544
48MP0002086_abnormal_extraembryonic_tissu1.11610905
49MP0002722_abnormal_immune_system1.11299262
50MP0009278_abnormal_bone_marrow1.10323127
51MP0008057_abnormal_DNA_replication1.04966558
52MP0002019_abnormal_tumor_incidence1.04946513
53MP0000689_abnormal_spleen_morphology1.04748341
54MP0004233_abnormal_muscle_weight1.01179782
55MP0001727_abnormal_embryo_implantation1.00920717
56MP0008877_abnormal_DNA_methylation0.98751217
57MP0000350_abnormal_cell_proliferation0.98630397
58MP0009333_abnormal_splenocyte_physiolog0.97614463
59MP0003221_abnormal_cardiomyocyte_apopto0.95519077
60MP0000343_altered_response_to0.95330768
61MP0005384_cellular_phenotype0.94965968
62MP0005385_cardiovascular_system_phenoty0.94289788
63MP0001544_abnormal_cardiovascular_syste0.94289788
64MP0005380_embryogenesis_phenotype0.91606222
65MP0001672_abnormal_embryogenesis/_devel0.91606222
66MP0004510_myositis0.90778576
67MP0002429_abnormal_blood_cell0.90688246
68MP0004947_skin_inflammation0.90518914
69MP0000372_irregular_coat_pigmentation0.89807242
70MP0005670_abnormal_white_adipose0.88838934
71MP0008260_abnormal_autophagy0.88429815
72MP0001145_abnormal_male_reproductive0.87661727
73MP0000653_abnormal_sex_gland0.87327456
74MP0005621_abnormal_cell_physiology0.86994925
75MP0004130_abnormal_muscle_cell0.86357541
76MP0005501_abnormal_skin_physiology0.86309884
77MP0003984_embryonic_growth_retardation0.83273697
78MP0002161_abnormal_fertility/fecundity0.82088166
79MP0002877_abnormal_melanocyte_morpholog0.81204311
80MP0000598_abnormal_liver_morphology0.79485416
81MP0002088_abnormal_embryonic_growth/wei0.78801091
82MP0004808_abnormal_hematopoietic_stem0.78286070
83MP0002736_abnormal_nociception_after0.77148792
84MP0005058_abnormal_lysosome_morphology0.76921521
85MP0005666_abnormal_adipose_tissue0.75340605
86MP0009931_abnormal_skin_appearance0.75297384
87MP0000230_abnormal_systemic_arterial0.73370205
88MP0009763_increased_sensitivity_to0.72599831
89MP0001851_eye_inflammation0.70064204
90MP0004085_abnormal_heartbeat0.69634610
91MP0003699_abnormal_female_reproductive0.68482841
92MP0003566_abnormal_cell_adhesion0.66917311
93MP0005535_abnormal_body_temperature0.66880011
94MP0001853_heart_inflammation0.64929325
95MP0003724_increased_susceptibility_to0.64371427
96MP0006276_abnormal_autonomic_nervous0.63848909
97MP0010352_gastrointestinal_tract_polyps0.62345225
98MP0009642_abnormal_blood_homeostasis0.61671307
99MP0008770_decreased_survivor_rate0.61463422
100MP0003638_abnormal_response/metabolism_0.59732257

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)7.37930211
2Cholecystitis (HP:0001082)7.37930211
3Prolonged bleeding time (HP:0003010)6.81768377
4Petechiae (HP:0000967)6.00702339
5Menorrhagia (HP:0000132)5.78342720
6Increased mean platelet volume (HP:0011877)5.46492218
7Abnormality of the heme biosynthetic pathway (HP:0010472)5.13840612
8Abnormal platelet volume (HP:0011876)5.04314245
9Reticulocytosis (HP:0001923)4.86296754
10Truncus arteriosus (HP:0001660)4.83687568
11Poikilocytosis (HP:0004447)4.80881342
12Upper limb muscle weakness (HP:0003484)4.66357148
13Hyperthyroidism (HP:0000836)4.53646767
14Abnormal platelet function (HP:0011869)4.29120574
15Impaired platelet aggregation (HP:0003540)4.29120574
16Polycythemia (HP:0001901)4.24979284
17Epistaxis (HP:0000421)4.12450772
18Acanthocytosis (HP:0001927)3.99304641
19Purpura (HP:0000979)3.96064925
20Cholelithiasis (HP:0001081)3.46388059
21Ileus (HP:0002595)3.32308918
22Abnormal hemoglobin (HP:0011902)3.27257853
23Abnormality of reticulocytes (HP:0004312)3.24270030
24Abnormal large intestine physiology (HP:0012700)3.18052099
25Tinnitus (HP:0000360)3.10634150
26Abnormal gallbladder morphology (HP:0012437)3.10139979
27Seborrheic dermatitis (HP:0001051)3.09312440
28Ankyloglossia (HP:0010296)3.05472085
29Bowel incontinence (HP:0002607)3.04971057
30Paralysis (HP:0003470)3.00272649
31Birth length less than 3rd percentile (HP:0003561)2.98313731
32Gingival bleeding (HP:0000225)2.97254239
33Male infertility (HP:0003251)2.95393493
34Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.83477833
35Hyperlipoproteinemia (HP:0010980)2.80869397
36Cortical dysplasia (HP:0002539)2.79413321
37Hypertensive crisis (HP:0100735)2.74484886
38Abnormality of homocysteine metabolism (HP:0010919)2.70398578
39Homocystinuria (HP:0002156)2.70398578
40Abnormal pupillary function (HP:0007686)2.62814443
41Abnormality of lateral ventricle (HP:0030047)2.58580520
42Abnormality of glycolysis (HP:0004366)2.58321323
43Orthostatic hypotension (HP:0001278)2.49127966
44Dyschromatopsia (HP:0007641)2.47202503
45Increased serum pyruvate (HP:0003542)2.44842922
46Nausea (HP:0002018)2.44106078
47Abnormality of the gallbladder (HP:0005264)2.40549715
48Ventricular fibrillation (HP:0001663)2.38744699
49Breast hypoplasia (HP:0003187)2.28393726
50Abnormality of oral frenula (HP:0000190)2.25525913
51Hypoparathyroidism (HP:0000829)2.25235136
52Abnormality of the tricuspid valve (HP:0001702)2.21188967
53Gastrointestinal dysmotility (HP:0002579)2.20155223
54Atelectasis (HP:0100750)2.13533933
55Progressive external ophthalmoplegia (HP:0000590)2.12688259
56Hyperbilirubinemia (HP:0002904)2.08346308
57Myelodysplasia (HP:0002863)2.06592492
58Autoamputation (HP:0001218)2.05222334
59Papillary thyroid carcinoma (HP:0002895)2.03882009
60Insidious onset (HP:0003587)2.02992694
61Termporal pattern (HP:0011008)2.02992694
62Abnormal spermatogenesis (HP:0008669)2.02145204
63Abnormality of the common coagulation pathway (HP:0010990)1.99179249
64Thyroid carcinoma (HP:0002890)1.96221298
65Episodic fever (HP:0001954)1.88884531
66Increased serum ferritin (HP:0003281)1.87373190
67Degeneration of anterior horn cells (HP:0002398)1.86785327
68Abnormality of the anterior horn cell (HP:0006802)1.86785327
69Cerebral hemorrhage (HP:0001342)1.84454256
70Abnormality of sulfur amino acid metabolism (HP:0004339)1.84296127
71Short middle phalanx of the 5th finger (HP:0004220)1.82646523
72Abnormally folded helix (HP:0008544)1.81834390
73Neuroendocrine neoplasm (HP:0100634)1.81772490
74Abnormality of cochlea (HP:0000375)1.80923602
75Acute myeloid leukemia (HP:0004808)1.80253845
76Easy fatigability (HP:0003388)1.78840479
77Multiple enchondromatosis (HP:0005701)1.78556202
78Abnormality of iron homeostasis (HP:0011031)1.77199566
79Peripheral hypomyelination (HP:0007182)1.75551231
80Spontaneous abortion (HP:0005268)1.70350431
81Spontaneous hematomas (HP:0007420)1.69503067
82Dysautonomia (HP:0002459)1.67014750
83Abnormality of transition element cation homeostasis (HP:0011030)1.64445260
84Aplasia/Hypoplasia of the earlobes (HP:0009906)1.64170448
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.63864245
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.63864245
87Generalized aminoaciduria (HP:0002909)1.63448410
88Bruising susceptibility (HP:0000978)1.62358277
89Aplasia/Hypoplasia of the thymus (HP:0010515)1.60106388
90Cerebral hypomyelination (HP:0006808)1.58845210
91Hepatosplenomegaly (HP:0001433)1.55115702
92Postnatal microcephaly (HP:0005484)1.54485449
93Flat cornea (HP:0007720)1.52205826
94Central scotoma (HP:0000603)1.50773794
95Obstructive lung disease (HP:0006536)1.47961307
96Chronic obstructive pulmonary disease (HP:0006510)1.47961307
97Fatigue (HP:0012378)1.47492451
98Delayed puberty (HP:0000823)1.47022172
99Acute encephalopathy (HP:0006846)1.46880507
100Morphological abnormality of the inner ear (HP:0011390)1.46076320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.10359447
2RIPK45.07957731
3MST44.82591592
4BMX3.42740816
5KSR22.32424147
6BUB12.25999095
7MAP3K22.21800862
8TTK2.03569830
9MYLK2.00477592
10BMPR21.85575008
11MAPKAPK31.82156194
12PLK41.80226063
13BRSK21.54622806
14CCNB11.50848235
15RAF11.49703328
16CLK11.42585240
17STK31.42190205
18TESK21.40373490
19MAP3K41.39839089
20BTK1.39364208
21NTRK31.31361330
22GRK61.30592888
23PTK2B1.30578281
24MAP3K61.28982775
25ILK1.28146860
26TEC1.28067021
27RET1.25108834
28EEF2K1.24070502
29PAK11.18695771
30ZAP701.18113875
31SIK31.15019957
32PLK21.13110349
33SCYL21.07626249
34NME11.07251842
35MAP3K81.06110505
36MAP2K71.02509808
37IRAK30.99767647
38KSR10.98284873
39SYK0.97595431
40NUAK10.93719093
41STK160.89926137
42BRD40.88952890
43PKN10.87502841
44TAOK30.86947399
45WNK40.86526327
46MATK0.86469862
47MAP2K10.85534658
48PIK3CG0.85389112
49RPS6KA40.80552520
50PDK20.80527618
51TRIM280.79784417
52PINK10.79762925
53SRPK10.78537157
54BLK0.78272616
55JAK20.78000199
56PLK30.76990729
57AURKA0.72029757
58DAPK10.70442733
59STK40.68537254
60BCR0.67145368
61STK100.67011933
62AKT30.66330830
63NEK20.65894262
64TAOK20.64694301
65ATR0.63132478
66CDK120.60968501
67CSNK1G30.59946436
68DAPK30.54373188
69EIF2AK30.53183163
70NEK10.53035623
71PIM10.51748535
72PBK0.51488112
73BRSK10.48546121
74PRKD10.48042076
75DYRK30.47997387
76PKN20.47605380
77PLK10.46012609
78CAMKK20.45996918
79CSNK1A1L0.45834733
80CDK10.45812329
81CHEK10.45795826
82TESK10.44075651
83CHEK20.43907137
84PRKACG0.43327451
85HCK0.39469933
86ICK0.37878577
87TRPM70.37718759
88PAK20.37270695
89INSRR0.36999578
90JAK30.36472253
91CDK20.34355164
92LYN0.34352312
93RPS6KB20.34208463
94CDC70.33491414
95MAPKAPK50.33140125
96CDK70.32621375
97IKBKB0.31478562
98CAMK10.30766435
99ATM0.30701281
100CSNK1E0.30326583

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.82037462
2Mismatch repair_Homo sapiens_hsa034303.63348663
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.32587974
4One carbon pool by folate_Homo sapiens_hsa006703.12517739
5DNA replication_Homo sapiens_hsa030302.76410421
6SNARE interactions in vesicular transport_Homo sapiens_hsa041302.49646805
7Platelet activation_Homo sapiens_hsa046112.26209228
8Biosynthesis of amino acids_Homo sapiens_hsa012302.17062371
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04086676
10Homologous recombination_Homo sapiens_hsa034402.03803702
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.00560089
12Pentose phosphate pathway_Homo sapiens_hsa000301.95813473
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91835765
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76746440
15RNA transport_Homo sapiens_hsa030131.74669117
16Basal transcription factors_Homo sapiens_hsa030221.73975515
17Nucleotide excision repair_Homo sapiens_hsa034201.67005665
18Collecting duct acid secretion_Homo sapiens_hsa049661.59115551
19Cell cycle_Homo sapiens_hsa041101.59099876
20Carbon metabolism_Homo sapiens_hsa012001.58521037
21Steroid biosynthesis_Homo sapiens_hsa001001.51117639
22Fructose and mannose metabolism_Homo sapiens_hsa000511.49483689
23RNA polymerase_Homo sapiens_hsa030201.47460762
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43366453
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41687297
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41555386
27Sulfur metabolism_Homo sapiens_hsa009201.40852017
28Fatty acid elongation_Homo sapiens_hsa000621.40197537
29Fanconi anemia pathway_Homo sapiens_hsa034601.34455539
30Thyroid cancer_Homo sapiens_hsa052161.32606886
31Parkinsons disease_Homo sapiens_hsa050121.29960057
32Pyrimidine metabolism_Homo sapiens_hsa002401.29950613
33Acute myeloid leukemia_Homo sapiens_hsa052211.24067077
34Spliceosome_Homo sapiens_hsa030401.21757203
35Shigellosis_Homo sapiens_hsa051311.21133140
36Pyruvate metabolism_Homo sapiens_hsa006201.19705116
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15344792
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08549308
39Type II diabetes mellitus_Homo sapiens_hsa049301.05929235
40Purine metabolism_Homo sapiens_hsa002301.05371163
41Oocyte meiosis_Homo sapiens_hsa041141.03116072
42Viral carcinogenesis_Homo sapiens_hsa052031.03085049
43Non-homologous end-joining_Homo sapiens_hsa034501.02059223
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.97223759
45Proteasome_Homo sapiens_hsa030500.96563379
46RNA degradation_Homo sapiens_hsa030180.96211739
47Oxidative phosphorylation_Homo sapiens_hsa001900.92693710
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91410922
49Galactose metabolism_Homo sapiens_hsa000520.89830797
50mRNA surveillance pathway_Homo sapiens_hsa030150.84946682
51Renal cell carcinoma_Homo sapiens_hsa052110.84320185
52Olfactory transduction_Homo sapiens_hsa047400.83906897
53Insulin signaling pathway_Homo sapiens_hsa049100.82433642
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81557797
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81516327
56mTOR signaling pathway_Homo sapiens_hsa041500.80726289
57Non-small cell lung cancer_Homo sapiens_hsa052230.79870972
58Huntingtons disease_Homo sapiens_hsa050160.78506651
59Vibrio cholerae infection_Homo sapiens_hsa051100.76308310
60Chronic myeloid leukemia_Homo sapiens_hsa052200.74462547
61HIF-1 signaling pathway_Homo sapiens_hsa040660.74187938
62Glutathione metabolism_Homo sapiens_hsa004800.73565974
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70830454
64Base excision repair_Homo sapiens_hsa034100.70369340
65Butanoate metabolism_Homo sapiens_hsa006500.70263671
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70249345
67Pancreatic cancer_Homo sapiens_hsa052120.67996182
68Gap junction_Homo sapiens_hsa045400.66449753
69ErbB signaling pathway_Homo sapiens_hsa040120.65326458
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.63107929
71Endometrial cancer_Homo sapiens_hsa052130.61055373
72Synaptic vesicle cycle_Homo sapiens_hsa047210.60998074
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60295154
74Selenocompound metabolism_Homo sapiens_hsa004500.57123427
75Choline metabolism in cancer_Homo sapiens_hsa052310.53227057
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.52305192
77VEGF signaling pathway_Homo sapiens_hsa043700.50133807
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46793415
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46660584
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46050083
81Alcoholism_Homo sapiens_hsa050340.44364935
82Metabolic pathways_Homo sapiens_hsa011000.43523581
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43292090
84Glioma_Homo sapiens_hsa052140.42420685
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.41390059
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40996511
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40938948
88Fatty acid metabolism_Homo sapiens_hsa012120.39717097
89Endocytosis_Homo sapiens_hsa041440.38815792
90Fatty acid biosynthesis_Homo sapiens_hsa000610.37669833
91Prostate cancer_Homo sapiens_hsa052150.35438422
92Arginine and proline metabolism_Homo sapiens_hsa003300.31645962
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29059202
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27937334
95Hematopoietic cell lineage_Homo sapiens_hsa046400.26372552
96Epstein-Barr virus infection_Homo sapiens_hsa051690.26117218
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26064563
98Apoptosis_Homo sapiens_hsa042100.25574906
99Chemokine signaling pathway_Homo sapiens_hsa040620.25258634
100N-Glycan biosynthesis_Homo sapiens_hsa005100.23135649

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