ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	substrate-independent telencephalic tangential migration (GO:0021826)	7.92593157
2	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	7.92593157
3	dopamine transport (GO:0015872)	7.83829527
4	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	7.77388270
5	peristalsis (GO:0030432)	7.41948610
6	mating behavior (GO:0007617)	6.65819104
7	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	6.41367839
8	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	6.41367839
9	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	6.00466489
10	phenol-containing compound catabolic process (GO:0019336)	5.86263590
11	prepulse inhibition (GO:0060134)	5.74019446
12	lens fiber cell development (GO:0070307)	5.47227872
13	cerebellar granule cell differentiation (GO:0021707)	5.38401095
14	behavioral response to cocaine (GO:0048148)	5.37651225
15	maternal behavior (GO:0042711)	5.35415080
16	astrocyte development (GO:0014002)	5.31766609
17	regulation of neurotransmitter uptake (GO:0051580)	5.20382525
18	synaptic transmission, dopaminergic (GO:0001963)	5.06635106
19	striatum development (GO:0021756)	5.02193602
20	adult walking behavior (GO:0007628)	5.00157845
21	catecholamine transport (GO:0051937)	4.99808194
22	phasic smooth muscle contraction (GO:0014821)	4.99031805
23	transmission of nerve impulse (GO:0019226)	4.97592400
24	cell proliferation in forebrain (GO:0021846)	4.82745874
25	parental behavior (GO:0060746)	4.77560678
26	asymmetric protein localization (GO:0008105)	4.46474673
27	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	4.28536719
28	stem cell development (GO:0048864)	4.24377125
29	sex differentiation (GO:0007548)	4.23482466
30	hormone catabolic process (GO:0042447)	4.14747226
31	positive regulation of synapse assembly (GO:0051965)	4.12047333
32	negative regulation of cAMP-mediated signaling (GO:0043951)	4.08547825
33	neuronal action potential (GO:0019228)	4.06155143
34	positive regulation of potassium ion transport (GO:0043268)	3.78431784
35	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	3.75637428
36	regulation of dopamine metabolic process (GO:0042053)	3.74433954
37	regulation of catecholamine metabolic process (GO:0042069)	3.74433954
38	regulation of synaptic transmission, dopaminergic (GO:0032225)	3.71473155
39	maturation of 5.8S rRNA (GO:0000460)	3.70925736
40	somatic stem cell division (GO:0048103)	3.66700086
41	dopamine metabolic process (GO:0042417)	3.64518652
42	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	3.63487324
43	long term synaptic depression (GO:0060292)	3.63114681
44	presynaptic membrane organization (GO:0097090)	3.56760896
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.56623639
46	response to amphetamine (GO:0001975)	3.55308597
47	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.51542188
48	protein polyglutamylation (GO:0018095)	3.45282609
49	grooming behavior (GO:0007625)	3.39030776
50	opioid receptor signaling pathway (GO:0038003)	3.35768681
51	cellular response to catecholamine stimulus (GO:0071870)	3.32433072
52	cellular response to monoamine stimulus (GO:0071868)	3.32433072
53	cochlea development (GO:0090102)	3.31773990
54	neuron recognition (GO:0008038)	3.30260236
55	tryptophan catabolic process (GO:0006569)	3.26148658
56	indole-containing compound catabolic process (GO:0042436)	3.26148658
57	indolalkylamine catabolic process (GO:0046218)	3.26148658
58	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.22992431
59	vasodilation (GO:0042311)	3.22616412
60	thyroid hormone generation (GO:0006590)	3.21570274
61	axonemal dynein complex assembly (GO:0070286)	3.17564716
62	response to monoamine (GO:0071867)	3.15687505
63	response to catecholamine (GO:0071869)	3.15687505
64	motile cilium assembly (GO:0044458)	3.12970584
65	ephrin receptor signaling pathway (GO:0048013)	3.09287268
66	positive regulation of cAMP-mediated signaling (GO:0043950)	3.06104083
67	dentate gyrus development (GO:0021542)	3.04383051
68	monoamine transport (GO:0015844)	3.04179784
69	nephron tubule morphogenesis (GO:0072078)	3.03470888
70	nephron epithelium morphogenesis (GO:0072088)	3.03470888
71	cilium movement (GO:0003341)	2.99055180
72	regulation of synapse assembly (GO:0051963)	2.96954246
73	sodium-independent organic anion transport (GO:0043252)	2.94226239
74	adult locomotory behavior (GO:0008344)	2.91956093
75	neuronal stem cell maintenance (GO:0097150)	2.91021524
76	neuron fate determination (GO:0048664)	2.90005956
77	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.89964847
78	activation of adenylate cyclase activity (GO:0007190)	2.88799953
79	stem cell division (GO:0017145)	2.85528927
80	auditory receptor cell stereocilium organization (GO:0060088)	2.83970480
81	thyroid hormone metabolic process (GO:0042403)	2.80854213
82	central nervous system myelination (GO:0022010)	2.79680379
83	axon ensheathment in central nervous system (GO:0032291)	2.79680379
84	cell aggregation (GO:0098743)	2.79611818
85	cartilage condensation (GO:0001502)	2.79611818
86	smooth muscle contraction (GO:0006939)	2.77416273
87	epithelial cilium movement (GO:0003351)	2.74743489
88	dopamine receptor signaling pathway (GO:0007212)	2.74703266
89	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.72647114
90	regulation of cardioblast proliferation (GO:0003264)	2.72647114
91	artery development (GO:0060840)	2.72472103
92	nonmotile primary cilium assembly (GO:0035058)	2.70560712
93	serotonin metabolic process (GO:0042428)	2.67702396
94	protein localization to cilium (GO:0061512)	2.65790439
95	behavioral fear response (GO:0001662)	2.63416989
96	behavioral defense response (GO:0002209)	2.63416989
97	regulation of timing of cell differentiation (GO:0048505)	2.62484323
98	telencephalon development (GO:0021537)	2.61376775
99	gamma-aminobutyric acid transport (GO:0015812)	2.60071511
100	positive regulation of adenylate cyclase activity (GO:0045762)	2.59827085

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.35489901
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.23685006
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.08506645
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.73262788
5	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.68651984
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.61403258
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.58663971
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.36792709
9	AR_21572438_ChIP-Seq_LNCaP_Human	2.04603162
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00911701
11	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.96399368
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.88198478
13	TAF15_26573619_Chip-Seq_HEK293_Human	1.85898293
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84589264
15	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.82338195
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.81382228
17	VDR_22108803_ChIP-Seq_LS180_Human	1.79255785
18	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.79044534
19	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.78192374
20	AHR_22903824_ChIP-Seq_MCF-7_Human	1.75457001
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.75328823
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.74032032
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.73109945
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.69574818
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68709953
26	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.67540807
27	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.66937830
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.66584240
29	RXR_22108803_ChIP-Seq_LS180_Human	1.64836063
30	STAT3_23295773_ChIP-Seq_U87_Human	1.62751842
31	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.62194502
32	AR_25329375_ChIP-Seq_VCAP_Human	1.60813629
33	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.55055153
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.54239169
35	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.52804040
36	P300_19829295_ChIP-Seq_ESCs_Human	1.52177845
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.49790622
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47081244
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46682864
40	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.44990944
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44440260
42	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.43224588
43	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.40933819
44	DROSHA_22980978_ChIP-Seq_HELA_Human	1.40291536
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40221696
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40221696
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38181284
48	TP53_18474530_ChIP-ChIP_U2OS_Human	1.37440494
49	TCF4_23295773_ChIP-Seq_U87_Human	1.36421593
50	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.36287725
51	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33688899
52	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.33477496
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.31485678
54	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.31339317
55	FUS_26573619_Chip-Seq_HEK293_Human	1.31062462
56	CJUN_26792858_Chip-Seq_BT549_Human	1.30703128
57	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.30532036
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29963096
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28355520
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.28063618
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28063618
62	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.27753375
63	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.27162828
64	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.27162828
65	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.26401097
66	IGF1R_20145208_ChIP-Seq_DFB_Human	1.25970737
67	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25422519
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24624317
69	EWS_26573619_Chip-Seq_HEK293_Human	1.22816769
70	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.22612336
71	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.22210574
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.21858978
73	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.21601604
74	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.20875009
75	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.19516437
76	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.18964498
77	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.18465985
78	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18183259
79	BCAT_22108803_ChIP-Seq_LS180_Human	1.17688742
80	KDM2B_26808549_Chip-Seq_REH_Human	1.16119461
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.14902896
82	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.14467653
83	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.13875269
84	JUN_21703547_ChIP-Seq_K562_Human	1.12628706
85	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.12106402
86	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.10500731
87	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.10349453
88	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.09289395
89	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09153205
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07657312
91	TBL1_22424771_ChIP-Seq_293T_Human	1.06010192
92	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05792704
93	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.04702509
94	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.04606877
95	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04546128
96	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.04296350
97	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.02909576
98	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02554716
99	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.01566053
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01519175

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.34094923
2	MP0000569_abnormal_digit_pigmentation	2.55515463
3	MP0002653_abnormal_ependyma_morphology	2.54699110
4	MP0001485_abnormal_pinna_reflex	2.14643695
5	MP0003880_abnormal_central_pattern	12.0110138
6	MP0000778_abnormal_nervous_system	1.93563846
7	MP0001984_abnormal_olfaction	1.82030712
8	MP0003868_abnormal_feces_composition	1.79033184
9	MP0000955_abnormal_spinal_cord	1.77268279
10	MP0000026_abnormal_inner_ear	1.70288021
11	MP0002736_abnormal_nociception_after	1.66849258
12	MP0002928_abnormal_bile_duct	1.62491262
13	MP0009046_muscle_twitch	1.59308622
14	MP0002234_abnormal_pharynx_morphology	1.55921661
15	MP0009250_abnormal_appendicular_skeleto	1.55871997
16	MP0004215_abnormal_myocardial_fiber	1.55481629
17	MP0002184_abnormal_innervation	1.52378993
18	MP0005551_abnormal_eye_electrophysiolog	1.51319441
19	MP0005171_absent_coat_pigmentation	1.50873647
20	MP0003011_delayed_dark_adaptation	1.50163928
21	MP0001529_abnormal_vocalization	1.49272389
22	MP0002102_abnormal_ear_morphology	1.45087866
23	MP0002282_abnormal_trachea_morphology	1.43201414
24	MP0005410_abnormal_fertilization	1.40860134
25	MP0009384_cardiac_valve_regurgitation	1.40355531
26	MP0001486_abnormal_startle_reflex	1.39334472
27	MP0002272_abnormal_nervous_system	1.33246575
28	MP0005174_abnormal_tail_pigmentation	1.26733754
29	MP0000631_abnormal_neuroendocrine_gland	1.24861371
30	MP0001968_abnormal_touch/_nociception	1.22660276
31	MP0001501_abnormal_sleep_pattern	1.22410649
32	MP0000383_abnormal_hair_follicle	1.22149737
33	MP0005253_abnormal_eye_physiology	1.22001638
34	MP0005423_abnormal_somatic_nervous	1.21746047
35	MP0003635_abnormal_synaptic_transmissio	1.20293089
36	MP0004859_abnormal_synaptic_plasticity	1.19131066
37	MP0002064_seizures	1.18604620
38	MP0005084_abnormal_gallbladder_morpholo	1.15316699
39	MP0003879_abnormal_hair_cell	1.14914335
40	MP0009745_abnormal_behavioral_response	1.14913333
41	MP0002249_abnormal_larynx_morphology	1.14083725
42	MP0003938_abnormal_ear_development	1.13792290
43	MP0001970_abnormal_pain_threshold	1.10256591
44	MP0002572_abnormal_emotion/affect_behav	1.07750763
45	MP0004043_abnormal_pH_regulation	1.03477131
46	MP0001440_abnormal_grooming_behavior	1.02042998
47	MP0005646_abnormal_pituitary_gland	1.00126959
48	MP0001963_abnormal_hearing_physiology	0.99466446
49	MP0002733_abnormal_thermal_nociception	0.99024590
50	MP0002735_abnormal_chemical_nociception	0.96289108
51	MP0008872_abnormal_physiological_respon	0.94145952
52	MP0003283_abnormal_digestive_organ	0.91449811
53	MP0002067_abnormal_sensory_capabilities	0.90894393
54	MP0002882_abnormal_neuron_morphology	0.90871016
55	MP0003698_abnormal_male_reproductive	0.90801238
56	MP0009053_abnormal_anal_canal	0.89871798
57	MP0000613_abnormal_salivary_gland	0.89729640
58	MP0004142_abnormal_muscle_tone	0.88966572
59	MP0002751_abnormal_autonomic_nervous	0.87973394
60	MP0005451_abnormal_body_composition	0.87698103
61	MP0000230_abnormal_systemic_arterial	0.87316109
62	MP0002108_abnormal_muscle_morphology	0.85711461
63	MP0003632_abnormal_nervous_system	0.82940227
64	MP0002557_abnormal_social/conspecific_i	0.82283813
65	MP0000534_abnormal_ureter_morphology	0.82269096
66	MP0001905_abnormal_dopamine_level	0.80562116
67	MP0003942_abnormal_urinary_system	0.79987365
68	MP0006276_abnormal_autonomic_nervous	0.78362485
69	MP0002638_abnormal_pupillary_reflex	0.76742478
70	MP0004484_altered_response_of	0.76651817
71	MP0000049_abnormal_middle_ear	0.75306265
72	MP0006072_abnormal_retinal_apoptosis	0.75259877
73	MP0005620_abnormal_muscle_contractility	0.75004201
74	MP0005508_abnormal_skeleton_morphology	0.74935342
75	MP0010329_abnormal_lipoprotein_level	0.74719103
76	MP0002752_abnormal_somatic_nervous	0.74335651
77	MP0005595_abnormal_vascular_smooth	0.73762699
78	MP0005670_abnormal_white_adipose	0.71735072
79	MP0001293_anophthalmia	0.71482075
80	MP0001764_abnormal_homeostasis	0.71336084
81	MP0003690_abnormal_glial_cell	0.70090726
82	MP0003633_abnormal_nervous_system	0.69309506
83	MP0002063_abnormal_learning/memory/cond	0.69140866
84	MP0003634_abnormal_glial_cell	0.68380396
85	MP0003935_abnormal_craniofacial_develop	0.67920776
86	MP0005195_abnormal_posterior_eye	0.67683160
87	MP0008569_lethality_at_weaning	0.66837004
88	MP0005391_vision/eye_phenotype	0.66643970
89	MP0003755_abnormal_palate_morphology	0.66192036
90	MP0002734_abnormal_mechanical_nocicepti	0.66157416
91	MP0005645_abnormal_hypothalamus_physiol	0.66112813
92	MP0003631_nervous_system_phenotype	0.65729893
93	MP0001944_abnormal_pancreas_morphology	0.65550444
94	MP0000427_abnormal_hair_cycle	0.64559291
95	MP0009115_abnormal_fat_cell	0.64177500
96	MP0001986_abnormal_taste_sensitivity	0.63701448
97	MP0004085_abnormal_heartbeat	0.62574371
98	MP0003195_calcinosis	0.62411098
99	MP0003936_abnormal_reproductive_system	0.62303513
100	MP0003861_abnormal_nervous_system	0.61283977

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	7.19221268
2	Oligodactyly (hands) (HP:0001180)	7.15736380
3	Fibular aplasia (HP:0002990)	6.95889584
4	Split foot (HP:0001839)	6.77878904
5	Humeroradial synostosis (HP:0003041)	6.76604223
6	Synostosis involving the elbow (HP:0003938)	6.76604223
7	Hypoplastic pelvis (HP:0008839)	6.76398747
8	Adactyly (HP:0009776)	5.22424018
9	Aplasia/hypoplasia of the uterus (HP:0008684)	4.66207559
10	Oligodactyly (HP:0012165)	4.65015215
11	Symphalangism affecting the phalanges of the hand (HP:0009773)	4.56723896
12	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	4.48500284
13	Broad ribs (HP:0000885)	4.29614911
14	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	4.23471492
15	Abnormality of the pubic bones (HP:0003172)	4.18550985
16	Hypoplastic nipples (HP:0002557)	4.05923727
17	Progressive cerebellar ataxia (HP:0002073)	3.88929921
18	Radial bowing (HP:0002986)	3.84699735
19	Aplasia/Hypoplasia of the fibula (HP:0006492)	3.80616612
20	Barrel-shaped chest (HP:0001552)	3.65376186
21	Hypoplastic iliac wings (HP:0002866)	3.58138829
22	Abnormal finger flexion creases (HP:0006143)	3.47564360
23	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	3.30791749
24	Abnormal ciliary motility (HP:0012262)	3.26869489
25	Skull defect (HP:0001362)	3.25273648
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.14753943
27	Absent/shortened dynein arms (HP:0200106)	3.14753943
28	Congenital stationary night blindness (HP:0007642)	3.05905329
29	Patellar aplasia (HP:0006443)	2.78117243
30	Genetic anticipation (HP:0003743)	2.77750186
31	Clumsiness (HP:0002312)	2.74581680
32	Abnormal respiratory motile cilium physiology (HP:0012261)	2.61508727
33	Hyperventilation (HP:0002883)	2.61004237
34	Cystic liver disease (HP:0006706)	2.60752166
35	Bowing of the arm (HP:0006488)	2.60640918
36	Bowed forearm bones (HP:0003956)	2.60640918
37	True hermaphroditism (HP:0010459)	2.55136601
38	Aplasia/Hypoplasia of the patella (HP:0006498)	2.54994492
39	Pancreatic fibrosis (HP:0100732)	2.53902733
40	Gait imbalance (HP:0002141)	2.53600449
41	Synostosis involving bones of the lower limbs (HP:0009138)	2.53411840
42	Synostosis involving bones of the feet (HP:0009140)	2.53411840
43	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.52789014
44	Chronic hepatic failure (HP:0100626)	2.51833114
45	Postural instability (HP:0002172)	2.50747135
46	Aplasia/Hypoplasia of the ulna (HP:0006495)	2.46505342
47	Medial flaring of the eyebrow (HP:0010747)	2.44424575
48	Hemivertebrae (HP:0002937)	2.43829812
49	Tarsal synostosis (HP:0008368)	2.40287706
50	Congenital primary aphakia (HP:0007707)	2.40238732
51	Aplasia involving forearm bones (HP:0009822)	2.37936688
52	Absent forearm bone (HP:0003953)	2.37936688
53	Abnormality of the fibula (HP:0002991)	2.36952243
54	Mesangial abnormality (HP:0001966)	2.32662377
55	Postaxial hand polydactyly (HP:0001162)	2.32383089
56	Action tremor (HP:0002345)	2.25893885
57	Ulnar deviation of finger (HP:0009465)	2.25065152
58	Abnormal respiratory epithelium morphology (HP:0012253)	2.24564511
59	Abnormal respiratory motile cilium morphology (HP:0005938)	2.24564511
60	Short foot (HP:0001773)	2.22842640
61	Decreased circulating renin level (HP:0003351)	2.21187195
62	Femoral bowing (HP:0002980)	2.20564899
63	Pancreatic cysts (HP:0001737)	2.20051975
64	Nephrogenic diabetes insipidus (HP:0009806)	2.16099800
65	Aplasia/Hypoplasia of the clavicles (HP:0006710)	2.15252682
66	Narrow palate (HP:0000189)	2.13287500
67	Molar tooth sign on MRI (HP:0002419)	2.05409251
68	Abnormality of midbrain morphology (HP:0002418)	2.05409251
69	Abnormality of the wing of the ilium (HP:0011867)	2.05174987
70	Hypoplastic ilia (HP:0000946)	2.01868436
71	Limb dystonia (HP:0002451)	2.00604629
72	Genital tract atresia (HP:0001827)	1.99985653
73	Abnormality of abdominal situs (HP:0011620)	1.99895198
74	Abdominal situs inversus (HP:0003363)	1.99895198
75	Sclerocornea (HP:0000647)	1.96267247
76	Renal dysplasia (HP:0000110)	1.95543215
77	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.95155316
78	Tubulointerstitial nephritis (HP:0001970)	1.94140525
79	Gastrointestinal atresia (HP:0002589)	1.93567453
80	Ulnar deviation of the hand or of fingers of the hand (HP:0001193)	1.93298874
81	Aplasia/hypoplasia of the femur (HP:0005613)	1.92776043
82	Hyperglycinemia (HP:0002154)	1.92625369
83	Poor coordination (HP:0002370)	1.90140432
84	Absent speech (HP:0001344)	1.90090832
85	Decreased skull ossification (HP:0004331)	1.88367126
86	Meningocele (HP:0002435)	1.86801437
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84675926
88	Aplasia/Hypoplasia of the lens (HP:0008063)	1.84401793
89	Chorioretinal atrophy (HP:0000533)	1.84086752
90	Scrotal hypoplasia (HP:0000046)	1.83022100
91	Abnormality of the humeroradial joint (HP:0100744)	1.82871625
92	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.82054690
93	Abnormality of the humerus (HP:0003063)	1.82050298
94	Retinal dysplasia (HP:0007973)	1.81262459
95	Esophageal atresia (HP:0002032)	1.81206037
96	Nephronophthisis (HP:0000090)	1.81193141
97	Type II lissencephaly (HP:0007260)	1.77904137
98	Abnormality of the upper arm (HP:0001454)	1.77890984
99	Impulsivity (HP:0100710)	1.77202069
100	Rhinitis (HP:0012384)	1.76127889

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	8.84997063
2	FRK	3.63841084
3	BMPR1B	3.27842154
4	LATS1	2.87254584
5	MAPK15	2.69977825
6	PINK1	2.56657407
7	BRD4	2.16769956
8	INSRR	1.92986331
9	WNK3	1.90647242
10	PNCK	1.87050607
11	STK38L	1.78743289
12	TGFBR1	1.76393526
13	CASK	1.72613115
14	AKT3	1.71479932
15	ADRBK2	1.41592045
16	EPHB1	1.40053890
17	PKN1	1.39352141
18	BMPR2	1.38230585
19	EPHA3	1.37887482
20	ACVR1B	1.37432954
21	NTRK3	1.33490199
22	PTK2B	1.30667546
23	NTRK2	1.30341623
24	PLK4	1.29601260
25	SGK2	1.25920194
26	OBSCN	1.22930353
27	MAPK13	1.19404686
28	MARK1	1.11667188
29	TYRO3	1.01043549
30	WNK4	0.99160652
31	GRK1	0.98741485
32	SGK223	0.96076479
33	SGK494	0.96076479
34	ERBB3	0.94303007
35	CDK8	0.93007041
36	CAMK1	0.92153986
37	ROCK1	0.88171288
38	PRKCG	0.87169004
39	DYRK3	0.84457564
40	CSNK1G2	0.83741401
41	STK38	0.83011986
42	ERBB2	0.81391368
43	CHUK	0.80787915
44	DYRK2	0.79924376
45	SIK1	0.79173902
46	CAMK2B	0.77548065
47	ADRBK1	0.74093081
48	MAP3K4	0.73411893
49	CAMK2G	0.70400768
50	LATS2	0.69335281
51	MAP3K10	0.68740095
52	CAMK2A	0.67885525
53	CDK9	0.65764563
54	TIE1	0.64059804
55	PRKCZ	0.62605978
56	MST1R	0.61978241
57	TAOK3	0.61279124
58	PIK3CG	0.60615850
59	MAP2K7	0.59228421
60	CAMK1G	0.56889059
61	PRKCE	0.56235708
62	STK3	0.55664320
63	PLK2	0.54585591
64	MAP2K1	0.53268937
65	MAP3K7	0.52122645
66	NEK9	0.51797743
67	CAMK2D	0.51485487
68	STK39	0.50795622
69	PRKAA2	0.49416734
70	PKN2	0.48790717
71	SGK3	0.47599566
72	MET	0.47118151
73	DDR2	0.46056825
74	CAMK4	0.45775627
75	MAPKAPK5	0.45409032
76	PRKAA1	0.43353321
77	SGK1	0.43080127
78	CSNK1A1	0.42711352
79	EPHA4	0.40223846
80	PAK3	0.40157120
81	CDK3	0.38670057
82	RPS6KA6	0.37649122
83	HIPK2	0.37603716
84	FER	0.37342550
85	PRKCB	0.36759697
86	RET	0.36459036
87	DYRK1A	0.33538345
88	OXSR1	0.32855311
89	MAP4K2	0.30775311
90	PRKG2	0.30225017
91	MATK	0.28947239
92	RPS6KA3	0.28571889
93	MUSK	0.28423030
94	ROCK2	0.27930869
95	PHKG1	0.27534933
96	PHKG2	0.27534933
97	IRAK1	0.27376265
98	PRKG1	0.27037917
99	PRKACA	0.26724654
100	CAMK1D	0.26622956

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cocaine addiction_Homo sapiens_hsa05030	3.91937735
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.29471101
3	Amphetamine addiction_Homo sapiens_hsa05031	2.87177283
4	Nicotine addiction_Homo sapiens_hsa05033	2.76079271
5	Olfactory transduction_Homo sapiens_hsa04740	2.55814872
6	Morphine addiction_Homo sapiens_hsa05032	2.46755834
7	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.22990533
8	Basal cell carcinoma_Homo sapiens_hsa05217	2.20476395
9	Axon guidance_Homo sapiens_hsa04360	2.15886302
10	Phototransduction_Homo sapiens_hsa04744	2.08152761
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00253605
12	Glutamatergic synapse_Homo sapiens_hsa04724	1.84988238
13	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.82314357
14	Dopaminergic synapse_Homo sapiens_hsa04728	1.80486054
15	Calcium signaling pathway_Homo sapiens_hsa04020	1.74651311
16	Butanoate metabolism_Homo sapiens_hsa00650	1.65749223
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.65525124
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.62562037
19	Circadian entrainment_Homo sapiens_hsa04713	1.60042728
20	Propanoate metabolism_Homo sapiens_hsa00640	1.58854207
21	cAMP signaling pathway_Homo sapiens_hsa04024	1.53524472
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43148860
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.37723470
24	Renin secretion_Homo sapiens_hsa04924	1.33661892
25	ABC transporters_Homo sapiens_hsa02010	1.32455617
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.31324035
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.30842863
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.30296501
29	Taste transduction_Homo sapiens_hsa04742	1.29721326
30	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.24058681
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.23664403
32	Type II diabetes mellitus_Homo sapiens_hsa04930	1.17916702
33	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.17407182
34	Insulin secretion_Homo sapiens_hsa04911	1.15304573
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12540904
36	Hippo signaling pathway_Homo sapiens_hsa04390	1.10367854
37	Circadian rhythm_Homo sapiens_hsa04710	1.10128701
38	GABAergic synapse_Homo sapiens_hsa04727	1.09098952
39	Melanogenesis_Homo sapiens_hsa04916	1.06699573
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04655734
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.02143388
42	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.01650063
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96595510
44	Serotonergic synapse_Homo sapiens_hsa04726	0.95172738
45	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.94370862
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93516747
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93353041
48	Caffeine metabolism_Homo sapiens_hsa00232	0.91315150
49	Histidine metabolism_Homo sapiens_hsa00340	0.87526919
50	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.85244498
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83205971
52	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.83011425
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.82391383
54	Bile secretion_Homo sapiens_hsa04976	0.81000484
55	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.80355398
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.79999850
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79759143
58	Cholinergic synapse_Homo sapiens_hsa04725	0.79146435
59	Retinol metabolism_Homo sapiens_hsa00830	0.77674610
60	Salivary secretion_Homo sapiens_hsa04970	0.77059603
61	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.76281230
62	Gap junction_Homo sapiens_hsa04540	0.72375515
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69833860
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.69529119
65	Gastric acid secretion_Homo sapiens_hsa04971	0.64106491
66	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63926526
67	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.63747956
68	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.63623359
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63194955
70	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.62276152
71	PPAR signaling pathway_Homo sapiens_hsa03320	0.61764976
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.60716218
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.59952967
74	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.59829190
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57688367
76	Rap1 signaling pathway_Homo sapiens_hsa04015	0.57087754
77	Phenylalanine metabolism_Homo sapiens_hsa00360	0.56721220
78	Long-term depression_Homo sapiens_hsa04730	0.56199333
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55267390
80	Complement and coagulation cascades_Homo sapiens_hsa04610	0.55266572
81	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.54926599
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54529779
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54358763
84	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.53094024
85	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.51751579
86	ECM-receptor interaction_Homo sapiens_hsa04512	0.51302559
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50507572
88	Insulin resistance_Homo sapiens_hsa04931	0.46247772
89	Estrogen signaling pathway_Homo sapiens_hsa04915	0.45849170
90	Notch signaling pathway_Homo sapiens_hsa04330	0.45777675
91	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.45209342
92	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.45091932
93	Alcoholism_Homo sapiens_hsa05034	0.40344209
94	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.40032882
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.38916423
96	Melanoma_Homo sapiens_hsa05218	0.38216584
97	Peroxisome_Homo sapiens_hsa04146	0.38077147
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37324241
99	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.33282773
100	Ras signaling pathway_Homo sapiens_hsa04014	0.30700280

CYP2G1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »