CYP2J2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* epoxygenase P450 pathway (GO:0019373)6.70695433
2drug catabolic process (GO:0042737)6.41148681
3exogenous drug catabolic process (GO:0042738)6.36920691
4cellular glucuronidation (GO:0052695)5.94445710
5NADH metabolic process (GO:0006734)5.79754113
6urea metabolic process (GO:0019627)5.78300851
7uronic acid metabolic process (GO:0006063)5.68744426
8glucuronate metabolic process (GO:0019585)5.68744426
9drug metabolic process (GO:0017144)5.66959414
10nitrogen cycle metabolic process (GO:0071941)5.38771592
11omega-hydroxylase P450 pathway (GO:0097267)5.38562766
12ethanol oxidation (GO:0006069)5.33755778
13urea cycle (GO:0000050)5.33409878
14glyoxylate metabolic process (GO:0046487)5.32880814
15regulation of triglyceride catabolic process (GO:0010896)5.17017680
16regulation of protein activation cascade (GO:2000257)4.95332845
17hormone catabolic process (GO:0042447)4.82145709
18regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.78763905
19complement activation, alternative pathway (GO:0006957)4.71605639
20regulation of bile acid biosynthetic process (GO:0070857)4.67068907
21ethanol metabolic process (GO:0006067)4.65940299
22angiotensin maturation (GO:0002003)4.63700912
23bile acid and bile salt transport (GO:0015721)4.62813927
24bile acid metabolic process (GO:0008206)4.62661441
25regulation of fibrinolysis (GO:0051917)4.62322402
26regulation of complement activation (GO:0030449)4.61909218
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.54694816
28L-phenylalanine catabolic process (GO:0006559)4.54694816
29negative regulation of fibrinolysis (GO:0051918)4.50533989
30L-phenylalanine metabolic process (GO:0006558)4.44276628
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.44276628
32fat-soluble vitamin biosynthetic process (GO:0042362)4.36920573
33phenylpropanoid metabolic process (GO:0009698)4.31783935
34fructose metabolic process (GO:0006000)4.22770711
35flavonoid metabolic process (GO:0009812)4.16973120
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.97617357
37peptidyl-glutamic acid carboxylation (GO:0017187)3.95730276
38protein carboxylation (GO:0018214)3.95730276
39bile acid biosynthetic process (GO:0006699)3.95066846
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.94705259
41oxidative demethylation (GO:0070989)3.91330910
42positive regulation of lipoprotein lipase activity (GO:0051006)3.90340176
43positive regulation of triglyceride lipase activity (GO:0061365)3.90340176
44very-low-density lipoprotein particle assembly (GO:0034379)3.86716913
45phospholipid efflux (GO:0033700)3.82980546
46regulation of cholesterol esterification (GO:0010872)3.82284151
47primary alcohol catabolic process (GO:0034310)3.74744046
48fibrinolysis (GO:0042730)3.72825254
49negative regulation of sterol transport (GO:0032372)3.62847605
50negative regulation of cholesterol transport (GO:0032375)3.62847605
51intestinal absorption (GO:0050892)3.61744480
52blood coagulation, intrinsic pathway (GO:0007597)3.61004578
53lipoprotein transport (GO:0042953)3.60214092
54alkaloid metabolic process (GO:0009820)3.57010995
55arginine metabolic process (GO:0006525)3.52665661
56plasma lipoprotein particle remodeling (GO:0034369)3.49951911
57protein-lipid complex remodeling (GO:0034368)3.49951911
58macromolecular complex remodeling (GO:0034367)3.49951911
59amino-acid betaine metabolic process (GO:0006577)3.47872323
60oxaloacetate metabolic process (GO:0006107)3.47147376
61positive regulation of lipid catabolic process (GO:0050996)3.45397477
62acylglycerol homeostasis (GO:0055090)3.44864129
63triglyceride homeostasis (GO:0070328)3.44864129
64drug transmembrane transport (GO:0006855)3.37550193
65negative regulation of blood coagulation (GO:0030195)3.36769287
66negative regulation of hemostasis (GO:1900047)3.36769287
67heme transport (GO:0015886)3.26968161
68high-density lipoprotein particle remodeling (GO:0034375)3.25889771
69protein activation cascade (GO:0072376)3.23383638
70phosphate ion transmembrane transport (GO:0035435)3.18112952
71complement activation, classical pathway (GO:0006958)3.17337635
72cholesterol efflux (GO:0033344)3.15384448
73drug transport (GO:0015893)3.15001837
74complement activation (GO:0006956)3.12973032
75proline metabolic process (GO:0006560)3.12713958
76plasma lipoprotein particle assembly (GO:0034377)3.10854659
77regulation of lipoprotein metabolic process (GO:0050746)3.07449623
78* xenobiotic metabolic process (GO:0006805)3.06636704
79negative regulation of coagulation (GO:0050819)3.06469964
80carnitine metabolic process (GO:0009437)3.03467174
81sarcomere organization (GO:0045214)3.02407642
82acute-phase response (GO:0006953)3.01878483
83glutamine family amino acid biosynthetic process (GO:0009084)3.01660682
84glutamate metabolic process (GO:0006536)2.99738638
85negative regulation of wound healing (GO:0061045)2.99389363
86serine family amino acid catabolic process (GO:0009071)2.97434745
87reverse cholesterol transport (GO:0043691)2.97167246
88protein-lipid complex assembly (GO:0065005)2.96171480
89cholesterol homeostasis (GO:0042632)2.91785773
90negative regulation of protein activation cascade (GO:2000258)2.91571019
91creatine metabolic process (GO:0006600)2.90137493
92monocarboxylic acid catabolic process (GO:0072329)2.89233349
93lipoprotein metabolic process (GO:0042157)2.87972017
94aromatic amino acid family catabolic process (GO:0009074)2.87448798
95primary alcohol metabolic process (GO:0034308)2.86450881
96daunorubicin metabolic process (GO:0044597)2.86430254
97polyketide metabolic process (GO:0030638)2.86430254
98doxorubicin metabolic process (GO:0044598)2.86430254
99amino-acid betaine transport (GO:0015838)2.86244318
100carnitine transport (GO:0015879)2.86244318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.99333467
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.57643321
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.94794037
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.84416918
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.79676754
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.36528630
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.34697440
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.72014374
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71399000
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.46583544
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06588506
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.00606757
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98466745
14ESR1_20079471_ChIP-ChIP_T-47D_Human1.96714938
15SOX2_27498859_Chip-Seq_STOMACH_Mouse1.82832309
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.81974159
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79198384
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74333642
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74187130
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.71964786
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.66006938
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.61394616
23PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.60913192
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.56591801
25GATA4_25053715_ChIP-Seq_YYC3_Human1.56578167
26AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.50367871
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46361033
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45663443
29* SOX2_20726797_ChIP-Seq_SW620_Human1.42291899
30GATA1_22025678_ChIP-Seq_K562_Human1.37186992
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35627983
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35352127
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.34905497
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34833458
35GATA6_25053715_ChIP-Seq_YYC3_Human1.31444246
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.30368177
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30260614
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30040169
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29821604
40TBX20_22080862_ChIP-Seq_HEART_Mouse1.29625553
41TBX20_22328084_ChIP-Seq_HEART_Mouse1.29625553
42CLOCK_20551151_ChIP-Seq_293T_Human1.28361628
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24610575
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22040644
45DROSHA_22980978_ChIP-Seq_HELA_Human1.20513545
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19185553
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.15562151
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14688846
49LXR_22292898_ChIP-Seq_THP-1_Human1.14187556
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12076311
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11634641
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09781459
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07543968
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07265835
55FOXA1_25552417_ChIP-Seq_VCAP_Human1.06793974
56CTCF_27219007_Chip-Seq_Bcells_Human1.05459539
57TCF4_18268006_ChIP-ChIP_LS174T_Human0.99855998
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99151902
59RACK7_27058665_Chip-Seq_MCF-7_Human0.97551908
60ZNF263_19887448_ChIP-Seq_K562_Human0.91402406
61HTT_18923047_ChIP-ChIP_STHdh_Human0.91340642
62TP63_17297297_ChIP-ChIP_HaCaT_Human0.89829826
63RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89043638
64ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88827286
65SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88338716
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87876670
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86250361
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86157133
69GATA3_24758297_ChIP-Seq_MCF-7_Human0.85930592
70* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84150626
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84094328
72* HNFA_21074721_ChIP-Seq_CACO-2_Human0.80924259
73* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80751271
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80314154
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80214822
76PIAS1_25552417_ChIP-Seq_VCAP_Human0.79119945
77CDX2_22108803_ChIP-Seq_LS180_Human0.78867043
78SMC4_20622854_ChIP-Seq_HELA_Human0.78136074
79DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78051793
80RUNX1_27514584_Chip-Seq_MCF-7_Human0.77811950
81CEBPB_22108803_ChIP-Seq_LS180_Human0.76885649
82CBP_21632823_ChIP-Seq_H3396_Human0.75767051
83SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74570757
84P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74165010
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73757428
86* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73215186
87SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72777975
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.72008554
89JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.71099307
90* SA1_27219007_Chip-Seq_Bcells_Human0.70986284
91CTNNB1_20460455_ChIP-Seq_HCT116_Human0.70583657
92* SOX2_21211035_ChIP-Seq_LN229_Human0.69561390
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.69415531
94SOX9_24532713_ChIP-Seq_HFSC_Mouse0.68865231
95* PHF8_20622853_ChIP-Seq_HELA_Human0.68518800
96GATA2_19941826_ChIP-Seq_K562_Human0.67332198
97GATA1_19941826_ChIP-Seq_K562_Human0.67170571
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.66925615
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66888035
100TP63_22573176_ChIP-Seq_HFKS_Human0.66587949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.46854441
2MP0002139_abnormal_hepatobiliary_system6.88188159
3MP0005085_abnormal_gallbladder_physiolo5.63721899
4MP0005365_abnormal_bile_salt4.82057524
5MP0001666_abnormal_nutrient_absorption3.93868406
6MP0008875_abnormal_xenobiotic_pharmacok3.86076335
7MP0003868_abnormal_feces_composition3.26455087
8MP0003252_abnormal_bile_duct2.83402586
9MP0009840_abnormal_foam_cell2.69937537
10MP0002138_abnormal_hepatobiliary_system2.65415137
11MP0010329_abnormal_lipoprotein_level2.48164186
12MP0004019_abnormal_vitamin_homeostasis2.45942881
13MP0003195_calcinosis2.36054026
14MP0000751_myopathy2.26685939
15MP0005332_abnormal_amino_acid2.24780071
16MP0005670_abnormal_white_adipose2.09444423
17MP0002876_abnormal_thyroid_physiology2.07660116
18MP0003183_abnormal_peptide_metabolism1.91734606
19MP0003806_abnormal_nucleotide_metabolis1.87756975
20MP0004084_abnormal_cardiac_muscle1.81150918
21MP0009697_abnormal_copulation1.80918805
22MP0005330_cardiomyopathy1.72837769
23MP0004036_abnormal_muscle_relaxation1.65376224
24MP0002118_abnormal_lipid_homeostasis1.60101066
25MP0004215_abnormal_myocardial_fiber1.52290623
26MP0004147_increased_porphyrin_level1.48459591
27MP0009643_abnormal_urine_homeostasis1.47693957
28MP0005451_abnormal_body_composition1.40157162
29MP0003191_abnormal_cellular_cholesterol1.35990643
30MP0004264_abnormal_extraembryonic_tissu1.34808408
31MP0002837_dystrophic_cardiac_calcinosis1.34305728
32MP0001764_abnormal_homeostasis1.32637505
33MP0000609_abnormal_liver_physiology1.31545898
34MP0000749_muscle_degeneration1.30616938
35MP0003879_abnormal_hair_cell1.29323751
36MP0002972_abnormal_cardiac_muscle1.24393584
37MP0003646_muscle_fatigue1.23049495
38MP0004145_abnormal_muscle_electrophysio1.22340507
39MP0004087_abnormal_muscle_fiber1.18174252
40MP0004484_altered_response_of1.16722103
41MP0005584_abnormal_enzyme/coenzyme_acti1.14922568
42MP0005636_abnormal_mineral_homeostasis1.13030072
43MP0010234_abnormal_vibrissa_follicle1.10465919
44MP0009780_abnormal_chondrocyte_physiolo1.09996536
45MP0008775_abnormal_heart_ventricle1.09515846
46MP0002971_abnormal_brown_adipose1.08042753
47MP0005409_darkened_coat_color1.07143962
48MP0006138_congestive_heart_failure1.05871564
49MP0002822_catalepsy1.03917534
50MP0005319_abnormal_enzyme/_coenzyme1.02025046
51MP0004130_abnormal_muscle_cell1.01060065
52MP0001544_abnormal_cardiovascular_syste1.00564240
53MP0005385_cardiovascular_system_phenoty1.00564240
54MP0005620_abnormal_muscle_contractility0.99659411
55MP0004043_abnormal_pH_regulation0.99489907
56MP0000747_muscle_weakness0.98856732
57MP0004270_analgesia0.97019939
58MP0010630_abnormal_cardiac_muscle0.91977744
59MP0005535_abnormal_body_temperature0.90721278
60MP0004510_myositis0.87661343
61MP0002132_abnormal_respiratory_system0.86070945
62MP0005166_decreased_susceptibility_to0.85588853
63MP0010155_abnormal_intestine_physiology0.84842973
64MP0002269_muscular_atrophy0.83391121
65MP0002106_abnormal_muscle_physiology0.82343891
66MP0001765_abnormal_ion_homeostasis0.82072984
67MP0009379_abnormal_foot_pigmentation0.80651126
68MP0005165_increased_susceptibility_to0.79925600
69MP0010368_abnormal_lymphatic_system0.78964823
70MP0003137_abnormal_impulse_conducting0.78574983
71MP0004085_abnormal_heartbeat0.77973956
72MP0009642_abnormal_blood_homeostasis0.77731221
73MP0001664_abnormal_digestion0.77621947
74MP0006036_abnormal_mitochondrial_physio0.74528986
75MP0005666_abnormal_adipose_tissue0.73520184
76MP0002078_abnormal_glucose_homeostasis0.71357486
77MP0005266_abnormal_metabolism0.70201291
78MP0005376_homeostasis/metabolism_phenot0.69800930
79MP0003638_abnormal_response/metabolism_0.67525497
80MP0002136_abnormal_kidney_physiology0.65983102
81MP0005369_muscle_phenotype0.64244450
82MP0005408_hypopigmentation0.62981284
83MP0002127_abnormal_cardiovascular_syste0.62624578
84MP0000604_amyloidosis0.61338142
85MP0000678_abnormal_parathyroid_gland0.61174635
86MP0000462_abnormal_digestive_system0.60176604
87MP0005187_abnormal_penis_morphology0.59547488
88MP0008872_abnormal_physiological_respon0.59453567
89MP0002332_abnormal_exercise_endurance0.58939197
90MP0005448_abnormal_energy_balance0.58771481
91MP0009115_abnormal_fat_cell0.58458848
92MP0000598_abnormal_liver_morphology0.55339047
93MP0000249_abnormal_blood_vessel0.54254074
94MP0005395_other_phenotype0.53556151
95MP0005334_abnormal_fat_pad0.53431950
96MP0001661_extended_life_span0.51685415
97MP0000759_abnormal_skeletal_muscle0.51215408
98MP0000538_abnormal_urinary_bladder0.50507531
99MP0003656_abnormal_erythrocyte_physiolo0.50306542
100MP0002249_abnormal_larynx_morphology0.49966888

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)6.88872477
2Hypobetalipoproteinemia (HP:0003563)6.32548645
3Abnormality of glutamine family amino acid metabolism (HP:0010902)6.20241315
4Deep venous thrombosis (HP:0002625)6.19441579
5Complement deficiency (HP:0004431)5.45243711
6Prolonged partial thromboplastin time (HP:0003645)4.85159734
7Systemic lupus erythematosus (HP:0002725)4.37856370
8Abnormality of complement system (HP:0005339)4.35730279
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.34443748
10Hydroxyprolinuria (HP:0003080)3.90863429
11Abnormality of proline metabolism (HP:0010907)3.90863429
12Sudden death (HP:0001699)3.83544108
13Xanthomatosis (HP:0000991)3.83490698
14Bundle branch block (HP:0011710)3.77191582
15Hypolipoproteinemia (HP:0010981)3.75946705
16Fat malabsorption (HP:0002630)3.72712066
17Conjugated hyperbilirubinemia (HP:0002908)3.65398931
18Intrahepatic cholestasis (HP:0001406)3.61641117
19Glomerulonephritis (HP:0000099)3.43849817
20Joint hemorrhage (HP:0005261)3.32428817
21Hyperlipoproteinemia (HP:0010980)3.31282117
22Hyperammonemia (HP:0001987)3.23280068
23Malnutrition (HP:0004395)3.22475871
24Ventricular tachycardia (HP:0004756)3.15609416
25Hyperglycinuria (HP:0003108)3.11156353
26Right ventricular cardiomyopathy (HP:0011663)3.11070211
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.09971937
28Abnormality of pyrimidine metabolism (HP:0004353)3.09658401
29Heart block (HP:0012722)2.99335853
30Exercise-induced myalgia (HP:0003738)2.87090911
31Abnormality of serine family amino acid metabolism (HP:0010894)2.87001937
32Abnormality of glycine metabolism (HP:0010895)2.87001937
33Hyporeflexia of lower limbs (HP:0002600)2.84772300
34Abnormal atrioventricular conduction (HP:0005150)2.83662341
35Muscle fiber splitting (HP:0003555)2.83405790
36Atrioventricular block (HP:0001678)2.82795858
37Abnormality of urine glucose concentration (HP:0011016)2.81141671
38Glycosuria (HP:0003076)2.81141671
39Asymmetric septal hypertrophy (HP:0001670)2.80842856
40Syncope (HP:0001279)2.73688756
41Distal lower limb muscle weakness (HP:0009053)2.73319883
42Muscle fiber inclusion bodies (HP:0100299)2.72271042
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.71656516
44Abnormality of vitamin metabolism (HP:0100508)2.66401076
45Steatorrhea (HP:0002570)2.66283597
46Nemaline bodies (HP:0003798)2.62428648
47Abnormality of nucleobase metabolism (HP:0010932)2.61158938
48Abnormality of the calf musculature (HP:0001430)2.51559873
49Vascular calcification (HP:0004934)2.50517179
50Widely patent fontanelles and sutures (HP:0004492)2.49366800
51Metabolic acidosis (HP:0001942)2.46664783
52Nephritis (HP:0000123)2.46496242
53Rhabdomyolysis (HP:0003201)2.45945343
54Abnormality of purine metabolism (HP:0004352)2.38930018
55Hemorrhage of the eye (HP:0011885)2.38724585
56Acanthocytosis (HP:0001927)2.34821571
57Abnormality of the common coagulation pathway (HP:0010990)2.33518311
58Generalized aminoaciduria (HP:0002909)2.33017072
59Dilated cardiomyopathy (HP:0001644)2.32346994
60Potter facies (HP:0002009)2.28902284
61Facial shape deformation (HP:0011334)2.28902284
62Increased purine levels (HP:0004368)2.28343588
63Hyperuricemia (HP:0002149)2.28343588
64Atrial fibrillation (HP:0005110)2.28076486
65EMG: myopathic abnormalities (HP:0003458)2.27606819
66Hyperphosphaturia (HP:0003109)2.27554031
67Myoglobinuria (HP:0002913)2.26673649
68Muscle hypertrophy of the lower extremities (HP:0008968)2.26341315
69Ventricular arrhythmia (HP:0004308)2.26284902
70Confusion (HP:0001289)2.25111961
71Epidermoid cyst (HP:0200040)2.24532969
72Calf muscle hypertrophy (HP:0008981)2.24433655
73Proximal tubulopathy (HP:0000114)2.22174064
74Hypoalphalipoproteinemia (HP:0003233)2.22082586
75Recurrent gram-negative bacterial infections (HP:0005420)2.20130737
76Type 1 muscle fiber predominance (HP:0003803)2.17705684
77Cardiovascular calcification (HP:0011915)2.17010434
78Abnormal urine phosphate concentration (HP:0012599)2.14330625
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.14063809
80Lipoatrophy (HP:0100578)2.11445155
81Ventricular fibrillation (HP:0001663)2.11348930
82Osteomalacia (HP:0002749)2.10677108
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09443858
84Abnormality of the intrinsic pathway (HP:0010989)2.08410606
85Hyperactive renin-angiotensin system (HP:0000841)2.06848638
86Pigmentary retinal degeneration (HP:0001146)2.03107363
87Rickets (HP:0002748)2.02529853
88Alkalosis (HP:0001948)2.02480741
89Gout (HP:0001997)2.02146608
90Centrally nucleated skeletal muscle fibers (HP:0003687)2.01498560
91Abnormality of the vitamin B12 metabolism (HP:0004341)1.99922455
92Palpitations (HP:0001962)1.99698201
93Skin nodule (HP:0200036)1.99210590
94Ileus (HP:0002595)1.98868574
95Primary atrial arrhythmia (HP:0001692)1.98282871
96Reduced antithrombin III activity (HP:0001976)1.96676534
97Abnormality of the left ventricular outflow tract (HP:0011103)1.89841597
98Subaortic stenosis (HP:0001682)1.89841597
99Hypercholesterolemia (HP:0003124)1.88483251
100Supraventricular tachycardia (HP:0004755)1.88188278

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.78533591
2MYLK3.59813274
3RIPK13.49385684
4ACVR1B3.47584330
5TTN3.06210870
6EPHA22.67353183
7ERN12.57560921
8MST1R2.54346782
9PIK3CA2.34334386
10TRIB32.23998866
11FGFR41.99932432
12DMPK1.99132321
13PHKG11.95146901
14PHKG21.95146901
15MUSK1.93591257
16MAPKAPK31.89038436
17LMTK21.86651571
18PIK3CG1.71512446
19MAP3K121.71308888
20PRKG21.65163568
21PDK21.56555645
22MAPK151.54349841
23MAP3K21.41749317
24EPHA41.41634732
25PRKAA21.36045358
26CAMK2D1.25025908
27CAMK2G1.19974017
28MAPK121.18221506
29MAP3K31.16393590
30PDPK11.16151961
31STK241.11642433
32MET1.09976565
33MAP3K71.09675759
34PRKACG1.07874208
35FGFR31.05807350
36PINK10.98455008
37TESK10.97133642
38PTK60.96788860
39EPHA30.96469859
40MST40.91155376
41PKN20.90754471
42EPHB10.86557653
43EEF2K0.86198214
44STK390.84968385
45AKT30.84653114
46CAMK2B0.83761490
47ICK0.82556880
48PRKD10.79953063
49PDK10.78088034
50MAP2K60.77922209
51PRKAA10.77359800
52PRPF4B0.75829854
53TRPM70.74524826
54PAK30.73493521
55KSR20.71021473
56TBK10.70756045
57MAP3K100.70538979
58LIMK10.69863203
59ROCK10.67284301
60MAPK110.64973878
61FER0.64831612
62NEK90.64421666
63CAMK2A0.63936876
64RET0.63344922
65MAP3K10.62418257
66MAP2K10.61913592
67MAP2K20.60989110
68SGK2230.60866341
69SGK4940.60866341
70PRKACA0.60628405
71PRKG10.59412726
72CDC42BPA0.57316062
73PRKCA0.56283088
74ERBB20.55811676
75MAP2K40.54044360
76PRKCZ0.52933146
77SIK10.52609528
78DYRK1B0.51336395
79TYK20.50227355
80SGK30.50053630
81AKT20.49795676
82NEK60.48692742
83CAMK40.47408518
84MAPK70.46576532
85MAPK40.45489282
86DAPK20.45293973
87ILK0.45092070
88NTRK30.44062429
89LRRK20.43908397
90ROCK20.43436926
91SGK10.42454201
92STK380.42335489
93MAP3K50.41522411
94MARK10.41053529
95PTK20.40587962
96SGK20.38650907
97TAOK10.38330040
98RPS6KA30.38302829
99DAPK30.34992680
100OXSR10.32446682

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31924123
2Caffeine metabolism_Homo sapiens_hsa002323.31468147
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.15239940
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97505863
5Retinol metabolism_Homo sapiens_hsa008302.88417308
6Arginine biosynthesis_Homo sapiens_hsa002202.78677658
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.76928081
8Chemical carcinogenesis_Homo sapiens_hsa052042.75445455
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71010513
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.65538397
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.65245599
12Phenylalanine metabolism_Homo sapiens_hsa003602.63088533
13Histidine metabolism_Homo sapiens_hsa003402.59060062
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.35165555
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.32411431
16Complement and coagulation cascades_Homo sapiens_hsa046102.31666185
17Fatty acid degradation_Homo sapiens_hsa000712.25157483
18Starch and sucrose metabolism_Homo sapiens_hsa005002.17123285
19Bile secretion_Homo sapiens_hsa049762.10672867
20Fat digestion and absorption_Homo sapiens_hsa049752.01921596
21PPAR signaling pathway_Homo sapiens_hsa033201.86547679
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81884008
23Vitamin digestion and absorption_Homo sapiens_hsa049771.79405486
24Tyrosine metabolism_Homo sapiens_hsa003501.79000843
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77031301
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75112323
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71131946
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.69825006
29Tryptophan metabolism_Homo sapiens_hsa003801.65683736
30Arginine and proline metabolism_Homo sapiens_hsa003301.61203508
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54625444
32Renin-angiotensin system_Homo sapiens_hsa046141.45669309
33* Linoleic acid metabolism_Homo sapiens_hsa005911.40439231
34Butanoate metabolism_Homo sapiens_hsa006501.32872462
35beta-Alanine metabolism_Homo sapiens_hsa004101.27693145
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22627480
37Peroxisome_Homo sapiens_hsa041461.19823344
38Fructose and mannose metabolism_Homo sapiens_hsa000511.14014005
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12792932
40Pyruvate metabolism_Homo sapiens_hsa006201.11703168
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09026411
42Sulfur metabolism_Homo sapiens_hsa009201.06793063
43Mineral absorption_Homo sapiens_hsa049781.05553235
44Carbon metabolism_Homo sapiens_hsa012001.00783030
45Biosynthesis of amino acids_Homo sapiens_hsa012301.00015879
46* Arachidonic acid metabolism_Homo sapiens_hsa005900.97802185
47Fatty acid metabolism_Homo sapiens_hsa012120.93426028
48Galactose metabolism_Homo sapiens_hsa000520.90923534
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90414746
50Propanoate metabolism_Homo sapiens_hsa006400.86985521
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81656112
52Protein digestion and absorption_Homo sapiens_hsa049740.74974058
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74930781
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.73746625
55ABC transporters_Homo sapiens_hsa020100.65828338
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65745363
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61935666
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.58699578
59Glycerolipid metabolism_Homo sapiens_hsa005610.57017100
60Prion diseases_Homo sapiens_hsa050200.55925370
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54949349
62Staphylococcus aureus infection_Homo sapiens_hsa051500.54811931
63Insulin resistance_Homo sapiens_hsa049310.52959247
64Pentose phosphate pathway_Homo sapiens_hsa000300.52817659
65Sulfur relay system_Homo sapiens_hsa041220.52632508
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50871420
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49280301
68Glucagon signaling pathway_Homo sapiens_hsa049220.47927044
69Dilated cardiomyopathy_Homo sapiens_hsa054140.46145249
70Vitamin B6 metabolism_Homo sapiens_hsa007500.46143892
71Glutathione metabolism_Homo sapiens_hsa004800.40758326
72Fatty acid elongation_Homo sapiens_hsa000620.38177640
73Cardiac muscle contraction_Homo sapiens_hsa042600.36644124
74* Metabolic pathways_Homo sapiens_hsa011000.36484735
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.31613846
76Fatty acid biosynthesis_Homo sapiens_hsa000610.29249594
77Sphingolipid metabolism_Homo sapiens_hsa006000.28571826
78Pancreatic secretion_Homo sapiens_hsa049720.26187151
79Renin secretion_Homo sapiens_hsa049240.24843997
80AMPK signaling pathway_Homo sapiens_hsa041520.24459468
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24150605
82Folate biosynthesis_Homo sapiens_hsa007900.23971125
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20924623
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.20162102
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19911734
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19088933
87Lysine degradation_Homo sapiens_hsa003100.18131075
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15952992
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15348036
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14711975
91Insulin signaling pathway_Homo sapiens_hsa049100.14162308
92Tight junction_Homo sapiens_hsa045300.13729711
93Insulin secretion_Homo sapiens_hsa049110.13607623
94Thyroid hormone synthesis_Homo sapiens_hsa049180.13289665
95Circadian rhythm_Homo sapiens_hsa047100.09944074
96Other glycan degradation_Homo sapiens_hsa005110.06988530
97Ether lipid metabolism_Homo sapiens_hsa005650.06206532
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.04887327
99Cocaine addiction_Homo sapiens_hsa050300.02044819
100Amphetamine addiction_Homo sapiens_hsa050310.00856754

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