CYP2S1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)7.22242538
2regulation of gene silencing by miRNA (GO:0060964)7.22242538
3regulation of gene silencing by RNA (GO:0060966)7.22242538
4interferon-gamma secretion (GO:0072643)6.62072264
5establishment of integrated proviral latency (GO:0075713)6.22610595
6intestinal epithelial cell development (GO:0060576)6.15571878
7purine nucleobase biosynthetic process (GO:0009113)5.98399846
8folic acid transport (GO:0015884)5.79515780
9folic acid metabolic process (GO:0046655)5.48391574
10ribosome assembly (GO:0042255)5.34431440
11L-alpha-amino acid transmembrane transport (GO:1902475)5.23163900
12protein complex localization (GO:0031503)5.19989751
13heterochromatin organization (GO:0070828)5.19847395
14L-serine metabolic process (GO:0006563)5.18582879
15vitamin transmembrane transport (GO:0035461)5.16166780
16positive regulation of SMAD protein import into nucleus (GO:0060391)5.16024973
17nucleobase biosynthetic process (GO:0046112)5.09170238
18lung-associated mesenchyme development (GO:0060484)5.06496363
19paraxial mesoderm development (GO:0048339)5.00592882
20pre-miRNA processing (GO:0031054)4.95331935
21regulation of cell fate specification (GO:0042659)4.79384474
22establishment of viral latency (GO:0019043)4.77667665
23maintenance of gastrointestinal epithelium (GO:0030277)4.55502360
24CDP-diacylglycerol metabolic process (GO:0046341)4.44596076
25modified amino acid transport (GO:0072337)4.33570058
26regulation of cardioblast differentiation (GO:0051890)4.32830861
27protein localization to kinetochore (GO:0034501)4.32032880
28blastocyst development (GO:0001824)4.25579144
29negative regulation of gene silencing (GO:0060969)4.21822579
30proteasome assembly (GO:0043248)4.20221185
31response to xenobiotic stimulus (GO:0009410)4.19691790
32vitamin transport (GO:0051180)4.18397399
33histone arginine methylation (GO:0034969)4.05622256
34IMP biosynthetic process (GO:0006188)4.05461499
35cellular protein complex localization (GO:0034629)4.05034906
36formation of translation preinitiation complex (GO:0001731)4.02586858
37labyrinthine layer development (GO:0060711)4.01408146
38NADH metabolic process (GO:0006734)3.95858842
39negative regulation of telomerase activity (GO:0051974)3.94917317
40regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.92320353
41mitotic metaphase plate congression (GO:0007080)3.89498825
42regulation of spindle organization (GO:0090224)3.88748109
43DNA unwinding involved in DNA replication (GO:0006268)3.86761485
44chromatin remodeling at centromere (GO:0031055)3.84144164
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.83615691
46negative regulation of androgen receptor signaling pathway (GO:0060766)3.83398906
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.80886539
48regulation of helicase activity (GO:0051095)3.77993049
49IMP metabolic process (GO:0046040)3.77244094
50regulation of SMAD protein import into nucleus (GO:0060390)3.76119433
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75295985
52DNA strand elongation involved in DNA replication (GO:0006271)3.74634966
53serine family amino acid biosynthetic process (GO:0009070)3.70253074
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69818119
55CENP-A containing nucleosome assembly (GO:0034080)3.69588535
56regulation of histone H3-K27 methylation (GO:0061085)3.66251487
57regulation of gene silencing (GO:0060968)3.64973393
58regulation of proton transport (GO:0010155)3.63818050
59epithelial structure maintenance (GO:0010669)3.60859457
60pantothenate metabolic process (GO:0015939)3.58507076
61regulation of histone H3-K9 methylation (GO:0051570)3.57281736
62DNA strand elongation (GO:0022616)3.57171757
63ribosome biogenesis (GO:0042254)3.56775920
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55898302
65cyclooxygenase pathway (GO:0019371)3.55553624
66regulation of cellular amino acid metabolic process (GO:0006521)3.50602062
67maturation of SSU-rRNA (GO:0030490)3.49782255
68anterior/posterior axis specification, embryo (GO:0008595)3.44210241
69regulation of chromatin silencing (GO:0031935)3.43629721
70nucleotide-sugar biosynthetic process (GO:0009226)3.43151543
71regulation of water loss via skin (GO:0033561)3.43060799
72regulation of G0 to G1 transition (GO:0070316)3.42732402
73bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41140250
74DNA replication-independent nucleosome organization (GO:0034724)3.40895838
75DNA replication-independent nucleosome assembly (GO:0006336)3.40895838
76negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.40534215
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.40534215
78negative regulation of mitotic sister chromatid segregation (GO:0033048)3.40534215
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.40534215
80negative regulation of sister chromatid segregation (GO:0033046)3.40534215
81trophectodermal cell differentiation (GO:0001829)3.39899096
82protein localization to chromosome, centromeric region (GO:0071459)3.39232252
83negative regulation of chromosome segregation (GO:0051985)3.39143379
84keratinocyte development (GO:0003334)3.37017622
85establishment of apical/basal cell polarity (GO:0035089)3.36560486
86regulation of translation in response to stress (GO:0043555)3.36023896
87regulation of cell fate commitment (GO:0010453)3.34972166
88positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34149819
89nodal signaling pathway (GO:0038092)3.33452654
90surfactant homeostasis (GO:0043129)3.32964739
91histone-serine phosphorylation (GO:0035404)3.29020104
92convergent extension (GO:0060026)3.27211328
93CDP-diacylglycerol biosynthetic process (GO:0016024)3.26659274
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24232637
95regulation of mitotic spindle checkpoint (GO:1903504)3.24232637
96alditol phosphate metabolic process (GO:0052646)3.23626892
97positive regulation of Cdc42 GTPase activity (GO:0043089)3.22062381
98cell fate commitment involved in formation of primary germ layer (GO:0060795)3.19060887
99histone exchange (GO:0043486)3.18438452
100amino sugar catabolic process (GO:0046348)3.17208313
101autophagic vacuole assembly (GO:0000045)3.16889032
102regulation of stem cell maintenance (GO:2000036)3.16503966
103rRNA modification (GO:0000154)3.16080383
104UDP-N-acetylglucosamine metabolic process (GO:0006047)3.15410399
105negative regulation of cell fate specification (GO:0009996)3.14899773
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13978477
107negative regulation of ligase activity (GO:0051352)3.13978477
108GDP-mannose metabolic process (GO:0019673)3.10512657
109positive regulation of ligase activity (GO:0051351)3.10214376
110planar cell polarity pathway involved in neural tube closure (GO:0090179)3.09804700
111telomere maintenance via semi-conservative replication (GO:0032201)3.06735368
112negative regulation of histone methylation (GO:0031061)3.04756059
113phosphatidic acid metabolic process (GO:0046473)3.03978025
114phosphatidic acid biosynthetic process (GO:0006654)3.03978025
115establishment of skin barrier (GO:0061436)3.02643864
116ventricular cardiac muscle cell action potential (GO:0086005)3.02533818
117regulation of integrin-mediated signaling pathway (GO:2001044)3.00736997
118DNA damage response, detection of DNA damage (GO:0042769)2.99597769
119ribosomal small subunit assembly (GO:0000028)2.98312492
120signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98129757
121signal transduction involved in DNA damage checkpoint (GO:0072422)2.98129757
122negative regulation of cell fate commitment (GO:0010454)2.96959392
123cellular response to nitric oxide (GO:0071732)2.96685076
124signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.94042091
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.94042091
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.94042091
127nuclear pore complex assembly (GO:0051292)2.93644569
128tight junction assembly (GO:0070830)2.93330916
129homocysteine metabolic process (GO:0050667)2.93053353
130fructose metabolic process (GO:0006000)2.92667685
131signal transduction involved in cell cycle checkpoint (GO:0072395)2.92362045
132phosphatidylserine acyl-chain remodeling (GO:0036150)2.92314805
133regulation of nuclear cell cycle DNA replication (GO:0033262)2.92252869
134ATP-dependent chromatin remodeling (GO:0043044)2.89757677
135notochord development (GO:0030903)2.89490160
136termination of RNA polymerase I transcription (GO:0006363)2.89311551
137regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88904884
138single strand break repair (GO:0000012)2.88818374
139DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88436234
140negative regulation of mitosis (GO:0045839)2.88386680
141mitotic spindle checkpoint (GO:0071174)2.87265064
142transcription elongation from RNA polymerase III promoter (GO:0006385)2.85832497
143termination of RNA polymerase III transcription (GO:0006386)2.85832497
144chaperone-mediated protein transport (GO:0072321)2.85580876
145negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85340795
146regulation of chromosome segregation (GO:0051983)2.85169475
147multicellular organismal water homeostasis (GO:0050891)2.85135231
148mitotic spindle assembly checkpoint (GO:0007094)2.84917022
149regulation of DNA methylation (GO:0044030)2.84798716
150DNA replication checkpoint (GO:0000076)2.83682756
151regulation of mitotic spindle organization (GO:0060236)2.82909644
152regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82748846
153regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82748846
154positive regulation of chromosome segregation (GO:0051984)2.81921674
155spindle checkpoint (GO:0031577)2.81902591
156intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81678021
157signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81678021
158regulation of ubiquitin-protein transferase activity (GO:0051438)2.81380133
159transcription from RNA polymerase I promoter (GO:0006360)2.81010047
160DNA replication initiation (GO:0006270)2.79714073
161establishment of protein localization to mitochondrial membrane (GO:0090151)2.79471387
162regulation of sister chromatid segregation (GO:0033045)2.79258805
163regulation of mitotic sister chromatid separation (GO:0010965)2.79258805
164regulation of mitotic sister chromatid segregation (GO:0033047)2.79258805
165ribonucleoprotein complex biogenesis (GO:0022613)2.77787725
166L-methionine salvage (GO:0071267)2.77735175
167L-methionine biosynthetic process (GO:0071265)2.77735175
168amino acid salvage (GO:0043102)2.77735175
169regulation of translational fidelity (GO:0006450)2.77696707
170GMP metabolic process (GO:0046037)2.77351640
171lysine metabolic process (GO:0006553)2.76833044
172lysine catabolic process (GO:0006554)2.76833044
173regulation of telomere maintenance via telomerase (GO:0032210)2.76554979
174NADPH regeneration (GO:0006740)2.76071769
175cofactor transport (GO:0051181)2.75216165
176spindle assembly checkpoint (GO:0071173)2.75161705
177telomere maintenance via telomerase (GO:0007004)2.74897655
178metaphase plate congression (GO:0051310)2.74786503
179regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74029766
180negative regulation of RNA splicing (GO:0033119)2.73310970
181regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.72296561
182negative regulation of translation, ncRNA-mediated (GO:0040033)2.72162123
183regulation of translation, ncRNA-mediated (GO:0045974)2.72162123
184negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72162123
185galactose catabolic process (GO:0019388)2.70551521
186transcription elongation from RNA polymerase I promoter (GO:0006362)2.70495503
187sphingosine metabolic process (GO:0006670)2.70247134
188glutathione derivative metabolic process (GO:1901685)2.68916316
189glutathione derivative biosynthetic process (GO:1901687)2.68916316
190phosphatidylserine metabolic process (GO:0006658)2.68453071
191N-acetylneuraminate metabolic process (GO:0006054)2.67931257
192positive regulation of autophagy (GO:0010508)2.67592822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.31349493
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03983851
3ZNF263_19887448_ChIP-Seq_K562_Human2.87433739
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.86813755
5AR_21909140_ChIP-Seq_LNCAP_Human2.78855090
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.75249140
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70713655
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.68790965
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.65559985
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63991312
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59088202
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.58174971
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57059420
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55146477
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54319185
16E2F7_22180533_ChIP-Seq_HELA_Human2.51086709
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.44774997
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.31969698
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22858442
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21277530
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13328518
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11393683
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.09018480
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.05185463
25SOX2_27498859_Chip-Seq_STOMACH_Mouse2.04941039
26* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.03770824
27* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.00661727
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00174423
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.99568104
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97691869
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.95802376
32* NANOG_16153702_ChIP-ChIP_HESCs_Human1.91844160
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90304686
34SOX2_16153702_ChIP-ChIP_HESCs_Human1.84172678
35* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.81255820
36* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.81149750
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.79788399
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79123317
39TCF3_18692474_ChIP-Seq_MESCs_Mouse1.77457367
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74547901
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73353117
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70012660
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65035887
44GATA4_25053715_ChIP-Seq_YYC3_Human1.62819305
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60382699
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60096712
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.59849174
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.56714440
49XRN2_22483619_ChIP-Seq_HELA_Human1.56324753
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55964513
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53674364
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52619858
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51981808
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51217704
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50749124
56* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.46540977
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.46521800
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46151935
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.45470007
60VDR_23849224_ChIP-Seq_CD4+_Human1.43835338
61* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43041983
62OCT4_18692474_ChIP-Seq_MEFs_Mouse1.41671603
63ATF3_27146783_Chip-Seq_COLON_Human1.41462727
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40656077
65KDM5A_27292631_Chip-Seq_BREAST_Human1.40370953
66TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39885145
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38318405
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38318405
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38318405
70GATA6_25053715_ChIP-Seq_YYC3_Human1.37369758
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36615783
72RACK7_27058665_Chip-Seq_MCF-7_Human1.36510038
73GABP_19822575_ChIP-Seq_HepG2_Human1.35617473
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35453831
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35043596
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34769766
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32782037
78DCP1A_22483619_ChIP-Seq_HELA_Human1.31855132
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30375717
80NANOG_18692474_ChIP-Seq_MEFs_Mouse1.30299189
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30206482
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.30060582
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.28820504
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26551509
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.25519565
86SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24649710
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24388285
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24132156
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23984078
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23920286
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22383750
92SOX2_18692474_ChIP-Seq_MESCs_Mouse1.20559738
93NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20412607
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18980601
95GATA1_22025678_ChIP-Seq_K562_Human1.18854258
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18057901
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16048938
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.15879672
99* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.15208432
100CLOCK_20551151_ChIP-Seq_293T_Human1.15040926
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13783822
102* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13538655
103SALL1_21062744_ChIP-ChIP_HESCs_Human1.10880949
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09891356
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06313405
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05620100
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.03578502
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03057469
109TTF2_22483619_ChIP-Seq_HELA_Human1.02411915
110EGR1_19374776_ChIP-ChIP_THP-1_Human1.01811904
111HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01374449
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.00870378
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00505586
114* KAP1_27257070_Chip-Seq_ESCs_Mouse1.00491738
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99805545
116MYC_22102868_ChIP-Seq_BL_Human0.99671260
117NANOG_21062744_ChIP-ChIP_HESCs_Human0.99665366
118POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99106155
119TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98317265
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.98240488
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95558201
122POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.94907344
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94770122
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93012768
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93004812
126FOXP3_21729870_ChIP-Seq_TREG_Human0.92814535
127KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92403542
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92382108
129SOX17_20123909_ChIP-Seq_XEN_Mouse0.92286681
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91541715
131NANOG_18692474_ChIP-Seq_MESCs_Mouse0.91521757
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91462588
133* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90563038
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89710342
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89356081
136CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85908226
137HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85897659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH8.28849563
2MP0002254_reproductive_system_inflammat7.02408712
3MP0003693_abnormal_embryo_hatching4.93028369
4MP0009840_abnormal_foam_cell3.96204017
5MP0003718_maternal_effect3.05465919
6MP0003878_abnormal_ear_physiology2.97068745
7MP0005377_hearing/vestibular/ear_phenot2.97068745
8MP0003111_abnormal_nucleus_morphology2.94957692
9MP0004957_abnormal_blastocyst_morpholog2.85082311
10MP0009672_abnormal_birth_weight2.80336851
11MP0010234_abnormal_vibrissa_follicle2.65262491
12MP0003890_abnormal_embryonic-extraembry2.56746078
13MP0008260_abnormal_autophagy2.48321772
14MP0001664_abnormal_digestion2.39383696
15MP0001873_stomach_inflammation2.34807464
16MP0009379_abnormal_foot_pigmentation2.28086204
17MP0006292_abnormal_olfactory_placode2.27982385
18MP0004264_abnormal_extraembryonic_tissu2.20195954
19MP0010030_abnormal_orbit_morphology2.17168671
20MP0000537_abnormal_urethra_morphology2.13217102
21MP0002796_impaired_skin_barrier2.11295140
22MP0003315_abnormal_perineum_morphology1.91839641
23MP0000470_abnormal_stomach_morphology1.91688902
24MP0001293_anophthalmia1.91667463
25MP0004019_abnormal_vitamin_homeostasis1.91563745
26MP0001188_hyperpigmentation1.85681504
27MP0000566_synostosis1.85231269
28MP0010352_gastrointestinal_tract_polyps1.82665870
29MP0008877_abnormal_DNA_methylation1.80945105
30MP0004782_abnormal_surfactant_physiolog1.80036948
31MP0001666_abnormal_nutrient_absorption1.79533637
32MP0001756_abnormal_urination1.75062723
33MP0000579_abnormal_nail_morphology1.74896372
34MP0003077_abnormal_cell_cycle1.73296128
35MP0001730_embryonic_growth_arrest1.72309677
36MP0003806_abnormal_nucleotide_metabolis1.69686450
37MP0003567_abnormal_fetal_cardiomyocyte1.66216642
38MP0003786_premature_aging1.62535206
39MP0002132_abnormal_respiratory_system1.61509133
40MP0003136_yellow_coat_color1.59196728
41MP0008057_abnormal_DNA_replication1.57086472
42MP0004133_heterotaxia1.55439210
43MP0003941_abnormal_skin_development1.55428835
44MP0002697_abnormal_eye_size1.52988412
45MP0010678_abnormal_skin_adnexa1.51008556
46MP0001542_abnormal_bone_strength1.44205421
47MP0000383_abnormal_hair_follicle1.41166831
48MP0002111_abnormal_tail_morphology1.36366226
49MP0005395_other_phenotype1.35202684
50MP0009703_decreased_birth_body1.33135866
51MP0004272_abnormal_basement_membrane1.33036919
52MP0010094_abnormal_chromosome_stability1.32354761
53MP0003123_paternal_imprinting1.30395930
54MP0008932_abnormal_embryonic_tissue1.28637090
55MP0002098_abnormal_vibrissa_morphology1.26927699
56MP0008007_abnormal_cellular_replicative1.22525101
57MP0001672_abnormal_embryogenesis/_devel1.21703557
58MP0005380_embryogenesis_phenotype1.21703557
59MP0000477_abnormal_intestine_morphology1.20274472
60MP0003566_abnormal_cell_adhesion1.19531013
61MP0005501_abnormal_skin_physiology1.18297223
62MP0000049_abnormal_middle_ear1.17600239
63MP0003866_abnormal_defecation1.17570084
64MP0001661_extended_life_span1.16104225
65MP0000490_abnormal_crypts_of1.10694133
66MP0005058_abnormal_lysosome_morphology1.10229478
67MP0008875_abnormal_xenobiotic_pharmacok1.08618253
68MP0000678_abnormal_parathyroid_gland1.08339022
69MP0003984_embryonic_growth_retardation1.08101456
70MP0001216_abnormal_epidermal_layer1.07741144
71MP0002088_abnormal_embryonic_growth/wei1.06786166
72MP0000647_abnormal_sebaceous_gland1.06502777
73MP0000428_abnormal_craniofacial_morphol1.06461059
74MP0004197_abnormal_fetal_growth/weight/1.04922282
75MP0001958_emphysema1.03654564
76MP0009643_abnormal_urine_homeostasis1.03535028
77MP0005367_renal/urinary_system_phenotyp1.03138118
78MP0000516_abnormal_urinary_system1.03138118
79MP0005451_abnormal_body_composition1.01850377
80MP0010307_abnormal_tumor_latency1.00696678
81MP0002080_prenatal_lethality1.00238376
82MP0001485_abnormal_pinna_reflex0.99776670
83MP0005332_abnormal_amino_acid0.99501231
84MP0000462_abnormal_digestive_system0.99288700
85MP0003191_abnormal_cellular_cholesterol0.98212286
86MP0000432_abnormal_head_morphology0.98111171
87MP0001286_abnormal_eye_development0.97979192
88MP0000350_abnormal_cell_proliferation0.96707746
89MP0001299_abnormal_eye_distance/0.95861470
90MP0004084_abnormal_cardiac_muscle0.94737243
91MP0000627_abnormal_mammary_gland0.94420866
92MP0002086_abnormal_extraembryonic_tissu0.93070543
93MP0000313_abnormal_cell_death0.92381687
94MP0000377_abnormal_hair_follicle0.92295234
95MP0002653_abnormal_ependyma_morphology0.92180507
96MP0009278_abnormal_bone_marrow0.90127159
97MP0002089_abnormal_postnatal_growth/wei0.90071620
98MP0004185_abnormal_adipocyte_glucose0.89658229
99MP0001697_abnormal_embryo_size0.87529989
100MP0003705_abnormal_hypodermis_morpholog0.86910945
101MP0003186_abnormal_redox_activity0.86669033
102MP0003119_abnormal_digestive_system0.86625939
103MP0009333_abnormal_splenocyte_physiolog0.86134909
104MP0002136_abnormal_kidney_physiology0.84661772
105MP0002233_abnormal_nose_morphology0.83852624
106MP0005167_abnormal_blood-brain_barrier0.83638523
107MP0006138_congestive_heart_failure0.83410130
108MP0002085_abnormal_embryonic_tissue0.80644421
109MP0003861_abnormal_nervous_system0.79868630
110MP0004233_abnormal_muscle_weight0.77596841
111MP0001849_ear_inflammation0.77484130
112MP0003453_abnormal_keratinocyte_physiol0.75453473
113MP0000467_abnormal_esophagus_morphology0.75037710
114MP0001881_abnormal_mammary_gland0.73060121
115MP0010329_abnormal_lipoprotein_level0.73047300
116MP0001663_abnormal_digestive_system0.72043837
117MP0005381_digestive/alimentary_phenotyp0.70978764
118MP0005076_abnormal_cell_differentiation0.70885294
119MP0008058_abnormal_DNA_repair0.69940515
120MP0006035_abnormal_mitochondrial_morpho0.69871028
121MP0004858_abnormal_nervous_system0.69468057
122MP0002396_abnormal_hematopoietic_system0.69040950
123MP0002234_abnormal_pharynx_morphology0.68455560
124MP0003115_abnormal_respiratory_system0.68384117
125MP0005083_abnormal_biliary_tract0.68312067
126MP0002277_abnormal_respiratory_mucosa0.67155399
127MP0004484_altered_response_of0.66502537
128MP0003221_abnormal_cardiomyocyte_apopto0.64661826
129MP0005257_abnormal_intraocular_pressure0.64340265
130MP0000534_abnormal_ureter_morphology0.63223707
131MP0002084_abnormal_developmental_patter0.62823222
132MP0009697_abnormal_copulation0.60691719
133MP0000465_gastrointestinal_hemorrhage0.60159798
134MP0000762_abnormal_tongue_morphology0.59581619
135MP0003937_abnormal_limbs/digits/tail_de0.59342546
136MP0005165_increased_susceptibility_to0.58581337
137MP0009053_abnormal_anal_canal0.58455498
138MP0008995_early_reproductive_senescence0.58297714
139MP0002938_white_spotting0.58000566
140MP0002019_abnormal_tumor_incidence0.57623861
141MP0003938_abnormal_ear_development0.57478700
142MP0002092_abnormal_eye_morphology0.57406185
143MP0005360_urolithiasis0.57390713
144MP0005389_reproductive_system_phenotype0.56845796
145MP0002090_abnormal_vision0.56606166
146MP0000358_abnormal_cell_content/0.55780889
147MP0003936_abnormal_reproductive_system0.55232490
148MP0003121_genomic_imprinting0.54508955
149MP0008770_decreased_survivor_rate0.51500908

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.12659003
2Gout (HP:0001997)4.65912983
3Breast hypoplasia (HP:0003187)4.61356252
4Abnormality of the umbilical cord (HP:0010881)4.52500706
5Megaloblastic anemia (HP:0001889)4.35501314
6Choanal stenosis (HP:0000452)4.17420717
7Pustule (HP:0200039)3.99477899
8Colon cancer (HP:0003003)3.85268114
9Selective tooth agenesis (HP:0001592)3.81663057
10Abnormality of the labia minora (HP:0012880)3.81194078
11Ventricular fibrillation (HP:0001663)3.71281296
12Right ventricular cardiomyopathy (HP:0011663)3.67777861
13Ureteral duplication (HP:0000073)3.56894522
14Hyperactive renin-angiotensin system (HP:0000841)3.54704724
15Carpal bone hypoplasia (HP:0001498)3.45255196
16Maternal diabetes (HP:0009800)3.45037667
17Bilateral microphthalmos (HP:0007633)3.43360469
18Spastic diplegia (HP:0001264)3.42793183
19Hyperglycinuria (HP:0003108)3.42527998
20Rough bone trabeculation (HP:0100670)3.39529114
21Abnormality of the distal phalanges of the toes (HP:0010182)3.38327087
22Polycythemia (HP:0001901)3.31230243
23Hepatoblastoma (HP:0002884)3.29957808
24Abnormal number of erythroid precursors (HP:0012131)3.27199409
25Hyperglycinemia (HP:0002154)3.26987450
26Reticulocytopenia (HP:0001896)3.18936535
27Alopecia of scalp (HP:0002293)3.17604715
28Abnormal umbilical cord blood vessels (HP:0011403)3.17495844
29Single umbilical artery (HP:0001195)3.17495844
30Abnormality of the fetal cardiovascular system (HP:0010948)3.17495844
31Partial duplication of thumb phalanx (HP:0009944)3.06552095
32Congenital, generalized hypertrichosis (HP:0004540)3.03853031
33Prolonged neonatal jaundice (HP:0006579)3.03196893
34Cerebral hypomyelination (HP:0006808)3.02535517
35Absent septum pellucidum (HP:0001331)3.01100048
36Ileus (HP:0002595)2.99808072
37Patent foramen ovale (HP:0001655)2.99058894
38Birth length less than 3rd percentile (HP:0003561)2.98321541
39Abnormality of cells of the erythroid lineage (HP:0012130)2.97654017
40Hypoglycemic seizures (HP:0002173)2.96637167
41Bundle branch block (HP:0011710)2.94879969
42Abnormal lung lobation (HP:0002101)2.94854152
43Abnormalities of placenta or umbilical cord (HP:0001194)2.93320781
44Interstitial pulmonary disease (HP:0006530)2.91141974
45Nephroblastoma (Wilms tumor) (HP:0002667)2.87107050
46Chronic bronchitis (HP:0004469)2.85314884
47Abnormality of the lacrimal duct (HP:0011481)2.83518112
48Abnormality of the septum pellucidum (HP:0007375)2.78747437
49Cheilitis (HP:0100825)2.77804258
50Homocystinuria (HP:0002156)2.76972252
51Abnormality of homocysteine metabolism (HP:0010919)2.76972252
52Renal salt wasting (HP:0000127)2.75334150
53Fragile nails (HP:0001808)2.72217757
54Abnormality of glycine metabolism (HP:0010895)2.71863851
55Abnormality of serine family amino acid metabolism (HP:0010894)2.71863851
56Impulsivity (HP:0100710)2.65480688
57Multiple enchondromatosis (HP:0005701)2.64816610
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.63888250
59Osteolytic defects of the hand bones (HP:0009699)2.63888250
60Bronchomalacia (HP:0002780)2.63283426
61Embryonal renal neoplasm (HP:0011794)2.61477159
62Death in infancy (HP:0001522)2.60216200
63Aplasia/Hypoplasia of the patella (HP:0006498)2.58668074
64Entropion (HP:0000621)2.57145337
65Broad metatarsal (HP:0001783)2.55961186
66Short nail (HP:0001799)2.55939569
67Seborrheic dermatitis (HP:0001051)2.55837770
68Sparse eyelashes (HP:0000653)2.54547915
69Short hallux (HP:0010109)2.53483858
70Microretrognathia (HP:0000308)2.52454421
71Vaginal fistula (HP:0004320)2.49219510
72Premature ovarian failure (HP:0008209)2.48766557
73Partial duplication of the phalanx of hand (HP:0009999)2.47672574
74Abnormality of the salivary glands (HP:0010286)2.47046369
75Facial cleft (HP:0002006)2.47001424
76Progressive muscle weakness (HP:0003323)2.46864337
77Turricephaly (HP:0000262)2.46757204
78Patellar aplasia (HP:0006443)2.44334951
79Trismus (HP:0000211)2.44330725
80Abnormal trabecular bone morphology (HP:0100671)2.43947070
81Breast aplasia (HP:0100783)2.42208792
82Stenosis of the external auditory canal (HP:0000402)2.39730212
83Aplasia/Hypoplasia of the breasts (HP:0010311)2.36398445
84Symptomatic seizures (HP:0011145)2.36152780
85Absent hand (HP:0004050)2.36149892
86Hyperuricemia (HP:0002149)2.34194837
87Increased purine levels (HP:0004368)2.34194837
88Aplasia/Hypoplasia of the hallux (HP:0008362)2.34157052
89Atrioventricular block (HP:0001678)2.33734254
90Esophageal atresia (HP:0002032)2.33483007
91Premature rupture of membranes (HP:0001788)2.32329132
92Double outlet right ventricle (HP:0001719)2.29531460
93Congenital malformation of the right heart (HP:0011723)2.29531460
94Secondary amenorrhea (HP:0000869)2.29069041
95Abnormality of the nasolacrimal system (HP:0000614)2.28284864
96Glucose intolerance (HP:0000833)2.28027305
97Rectal fistula (HP:0100590)2.27823716
98Rectovaginal fistula (HP:0000143)2.27823716
99Meckel diverticulum (HP:0002245)2.27222343
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25359270
101Absent radius (HP:0003974)2.24141440
102Myelomeningocele (HP:0002475)2.21193444
103Abnormality of glycolipid metabolism (HP:0010969)2.20875233
104Abnormality of liposaccharide metabolism (HP:0010968)2.20875233
105Abnormality of glycosphingolipid metabolism (HP:0004343)2.20875233
106Abnormality of sulfur amino acid metabolism (HP:0004339)2.20029088
107Difficulty climbing stairs (HP:0003551)2.18563387
108Macrocytic anemia (HP:0001972)2.17664207
109Abnormality of the middle phalanges of the toes (HP:0010183)2.17563759
110Pili torti (HP:0003777)2.17444934
111Duplication of thumb phalanx (HP:0009942)2.16421971
112Cellular immunodeficiency (HP:0005374)2.15167767
113Cortical dysplasia (HP:0002539)2.14700816
114Synostosis involving the elbow (HP:0003938)2.14160643
115Humeroradial synostosis (HP:0003041)2.14160643
116Abnormality of the vitamin B12 metabolism (HP:0004341)2.13974929
117Absent eyelashes (HP:0000561)2.12617661
118Syncope (HP:0001279)2.12206253
119Abnormal number of incisors (HP:0011064)2.10912250
120Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10910393
121Abnormal biliary tract morphology (HP:0012440)2.10584429
122Split foot (HP:0001839)2.09783482
123Absent eyebrow (HP:0002223)2.09492170
124Coronal craniosynostosis (HP:0004440)2.08785660
125Shawl scrotum (HP:0000049)2.08549264
126Aplasia/Hypoplasia involving the musculature (HP:0001460)2.08188851
127Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08146818
128Gastrointestinal carcinoma (HP:0002672)2.07261093
129Malignant gastrointestinal tract tumors (HP:0006749)2.07261093
130Aplasia involving forearm bones (HP:0009822)2.06772898
131Absent forearm bone (HP:0003953)2.06772898
132Abnormality of the ileum (HP:0001549)2.05010519
133Myopathic facies (HP:0002058)2.04816557
134Stillbirth (HP:0003826)2.04059934
135Intestinal fistula (HP:0100819)2.01761651
136Shallow orbits (HP:0000586)2.00481131
137Pancreatic islet-cell hyperplasia (HP:0004510)1.99892428
138Hyperinsulinemic hypoglycemia (HP:0000825)1.98377677
139Fused cervical vertebrae (HP:0002949)1.96903178
140Woolly hair (HP:0002224)1.96358234
141Reduced subcutaneous adipose tissue (HP:0003758)1.96016089
142Tracheoesophageal fistula (HP:0002575)1.95626609
143Stomach cancer (HP:0012126)1.95534336
144Ankle contracture (HP:0006466)1.95447866
145Chromsome breakage (HP:0040012)1.95352272
146Abnormality of the anterior horn cell (HP:0006802)1.94111945
147Degeneration of anterior horn cells (HP:0002398)1.94111945
148Ependymoma (HP:0002888)1.94092213
149Uterine neoplasm (HP:0010784)1.94002926
150Premature loss of primary teeth (HP:0006323)1.93870653
151Hyperglycemia (HP:0003074)1.93827400
152Blepharitis (HP:0000498)1.93735304
153Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93605725
154Horseshoe kidney (HP:0000085)1.93240625
155Personality changes (HP:0000751)1.92205861
156Skull defect (HP:0001362)1.91357797
157Abnormality of serum amino acid levels (HP:0003112)1.91241465
158Pterygium (HP:0001059)1.91050672
159Segmental peripheral demyelination/remyelination (HP:0003481)1.90870417
160Nail dystrophy (HP:0008404)1.90739048
161Abnormality of chloride homeostasis (HP:0011422)1.90734540
162Absent hair (HP:0002298)1.90284367
163Biliary tract neoplasm (HP:0100574)1.88916510
164Wide nose (HP:0000445)1.88750653
165Abnormality of vitamin B metabolism (HP:0004340)1.88448742
166Nasolacrimal duct obstruction (HP:0000579)1.87796909
167Abnormal pancreas size (HP:0012094)1.87394942
168Onycholysis (HP:0001806)1.87109823
169Bifid tongue (HP:0010297)1.86794814
170Clitoromegaly (HP:0000057)1.86088628
171Neoplasm of the colon (HP:0100273)1.85633175
172Abnormal cartilage morphology (HP:0002763)1.85544248
173Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84954671
174Cleft eyelid (HP:0000625)1.83047907
175Increased nuchal translucency (HP:0010880)1.82862932
176Agnosia (HP:0010524)1.81468043
177Progressive external ophthalmoplegia (HP:0000590)1.80858679
178Reduced antithrombin III activity (HP:0001976)1.80511287
179Urethral obstruction (HP:0000796)1.80276716
180Muscle fiber splitting (HP:0003555)1.79763116
181Athetosis (HP:0002305)1.79330710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.53255625
2BUB15.69511331
3WEE14.71284420
4VRK24.02090128
5CDC73.83036691
6AKT33.51843100
7TSSK63.40066965
8TAF13.20181379
9PNCK3.10198637
10SMG13.06290079
11MAP3K103.02551413
12PBK2.99195476
13CDK192.62850495
14TNIK2.61479968
15MST42.50830977
16NEK12.46920380
17PLK42.20816968
18MKNK11.96526227
19NEK21.92166606
20PDK31.87517042
21PDK41.87517042
22EIF2AK11.83474119
23TTK1.80860580
24ERBB41.73035545
25IRAK31.72041795
26BMX1.71580101
27MST1R1.71484956
28PDK21.71366093
29BRSK21.68350507
30STK161.64523962
31DYRK21.61335341
32ZAK1.53317234
33MAP2K21.51456094
34CDK121.49514585
35PRKCI1.47835664
36NME11.45644244
37ARAF1.32869336
38FGFR11.26697506
39PLK31.24250382
40PLK11.24016584
41MAP3K31.23113071
42PASK1.22618109
43STK101.22066721
44PAK41.22039188
45STK38L1.21489358
46PIM21.20724783
47RPS6KB21.18526962
48VRK11.09273229
49NME21.05932510
50BRSK11.04826801
51AURKB1.03931713
52MAP3K81.03803275
53OXSR11.03149339
54SRPK11.00514712
55FER1.00176281
56EIF2AK30.99695504
57EEF2K0.94815045
58STK40.94390175
59LRRK20.93269208
60AURKA0.87805024
61STK240.86635196
62BRAF0.85204817
63ZAP700.84508164
64PAK10.84250093
65FGFR20.84150952
66MAP3K90.82339658
67NLK0.81897808
68DYRK30.79972646
69LATS10.79749236
70MET0.78401672
71ATR0.77856118
72STK30.76878305
73CAMK1D0.74031199
74MAP2K10.71941275
75TIE10.69399554
76TRIB30.68377597
77DMPK0.68280406
78PINK10.68103640
79ALK0.66715557
80MATK0.65973871
81RIPK10.62405718
82EPHB20.62192616
83TYRO30.59893569
84FGR0.59810790
85CHEK20.59124742
86ATM0.57939669
87PTK20.57148731
88TESK10.56687543
89CAMK1G0.55809870
90DAPK10.55290806
91CAMKK20.54427402
92ACVR1B0.54353923
93GRK10.53166715
94CDK40.52919283
95TESK20.51842226
96MYLK0.50965882
97TAOK10.50402402
98CDK70.48004186
99MAP3K20.47440466
100LMTK20.46750993
101CDK10.46248786
102EIF2AK20.45114009
103EGFR0.42952365
104NUAK10.42669443
105PRKDC0.42041402
106RPS6KA40.40185490
107LATS20.39165515
108CSNK1E0.39037945
109PTK60.38802177
110KDR0.38600723
111BRD40.37778441
112CCNB10.37667517
113NTRK10.35201891
114PDGFRA0.34467242
115MELK0.33371613
116RPS6KA10.33354372
117STK380.32451247
118WNK30.32439854
119MAP3K110.30388763
120BCKDK0.29897385
121CDK60.29512141
122CHEK10.27915545
123PDPK10.27815094
124FGFR40.27734207
125CSNK1G10.27655353
126PRKG20.27536670
127DAPK30.25710487
128CSNK2A10.23918307
129NEK90.22695558
130MKNK20.22527280
131GRK60.21418384
132DDR20.20251376
133CDK20.19240882
134CSNK1A10.19203479
135FRK0.18968490
136MARK10.18740210
137PAK30.18638195
138CAMK2G0.18594220
139AKT20.18568171
140KSR20.18000317
141ERBB20.16905127
142PIM10.16424535
143CSNK2A20.15628878

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.95516093
2Proteasome_Homo sapiens_hsa030504.31982147
3Vitamin digestion and absorption_Homo sapiens_hsa049773.29214670
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06393589
5RNA polymerase_Homo sapiens_hsa030203.04067716
6Regulation of autophagy_Homo sapiens_hsa041402.76628971
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.63034273
8Folate biosynthesis_Homo sapiens_hsa007902.60211836
9Glycerophospholipid metabolism_Homo sapiens_hsa005642.35187947
10RNA transport_Homo sapiens_hsa030132.28684829
11Glutathione metabolism_Homo sapiens_hsa004802.28682638
12Mineral absorption_Homo sapiens_hsa049782.25690851
13Fructose and mannose metabolism_Homo sapiens_hsa000512.07671584
14Pentose phosphate pathway_Homo sapiens_hsa000302.00942992
15Non-homologous end-joining_Homo sapiens_hsa034501.98773266
16Fat digestion and absorption_Homo sapiens_hsa049751.95530427
17Collecting duct acid secretion_Homo sapiens_hsa049661.93273814
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.88130977
19One carbon pool by folate_Homo sapiens_hsa006701.79896764
20Pyrimidine metabolism_Homo sapiens_hsa002401.65680810
21mRNA surveillance pathway_Homo sapiens_hsa030151.62722028
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50096401
23Renin-angiotensin system_Homo sapiens_hsa046141.49730857
24Cell cycle_Homo sapiens_hsa041101.49648288
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49077912
26Pyruvate metabolism_Homo sapiens_hsa006201.42968621
27* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40919359
28Tight junction_Homo sapiens_hsa045301.37682269
29Spliceosome_Homo sapiens_hsa030401.36534033
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34971045
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34296742
32Ribosome_Homo sapiens_hsa030101.29595713
33Huntingtons disease_Homo sapiens_hsa050161.28797247
34p53 signaling pathway_Homo sapiens_hsa041151.22543671
35Sphingolipid metabolism_Homo sapiens_hsa006001.22517564
36Chemical carcinogenesis_Homo sapiens_hsa052041.21217948
37RNA degradation_Homo sapiens_hsa030181.19282221
38DNA replication_Homo sapiens_hsa030301.16961959
39Oxidative phosphorylation_Homo sapiens_hsa001901.15756713
40Purine metabolism_Homo sapiens_hsa002301.15683631
41Basal cell carcinoma_Homo sapiens_hsa052171.13269074
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.12957056
43Parkinsons disease_Homo sapiens_hsa050121.12756542
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11457934
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10458085
46Glycerolipid metabolism_Homo sapiens_hsa005611.08646578
47Lysosome_Homo sapiens_hsa041421.07051146
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.05252357
49Arachidonic acid metabolism_Homo sapiens_hsa005901.04219095
50Linoleic acid metabolism_Homo sapiens_hsa005911.03652433
51Steroid biosynthesis_Homo sapiens_hsa001001.00703283
52Carbon metabolism_Homo sapiens_hsa012001.00317592
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00105637
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00012521
55Sulfur metabolism_Homo sapiens_hsa009200.96996316
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96932329
57Base excision repair_Homo sapiens_hsa034100.95892353
58Histidine metabolism_Homo sapiens_hsa003400.95203464
59Galactose metabolism_Homo sapiens_hsa000520.93834939
60Biosynthesis of amino acids_Homo sapiens_hsa012300.92690230
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92688635
62Arginine biosynthesis_Homo sapiens_hsa002200.91252269
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90868872
64Oocyte meiosis_Homo sapiens_hsa041140.90754838
65Epstein-Barr virus infection_Homo sapiens_hsa051690.88206921
66Gastric acid secretion_Homo sapiens_hsa049710.87901052
67Mismatch repair_Homo sapiens_hsa034300.85446393
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.83864135
69Wnt signaling pathway_Homo sapiens_hsa043100.82486670
70Selenocompound metabolism_Homo sapiens_hsa004500.81113412
71Starch and sucrose metabolism_Homo sapiens_hsa005000.80590015
72Hippo signaling pathway_Homo sapiens_hsa043900.80533970
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80238553
74beta-Alanine metabolism_Homo sapiens_hsa004100.79779128
75Sulfur relay system_Homo sapiens_hsa041220.77836877
76Basal transcription factors_Homo sapiens_hsa030220.77461410
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77113354
78Nucleotide excision repair_Homo sapiens_hsa034200.76800062
79Homologous recombination_Homo sapiens_hsa034400.73276778
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71143834
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70990607
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69909574
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69456642
84Fatty acid elongation_Homo sapiens_hsa000620.69199184
85Fanconi anemia pathway_Homo sapiens_hsa034600.68266995
86Antigen processing and presentation_Homo sapiens_hsa046120.61175212
87Arginine and proline metabolism_Homo sapiens_hsa003300.59837171
88Thyroid cancer_Homo sapiens_hsa052160.59057334
89Circadian rhythm_Homo sapiens_hsa047100.58029987
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57619425
91Alzheimers disease_Homo sapiens_hsa050100.56743343
92Protein export_Homo sapiens_hsa030600.56269605
93Adherens junction_Homo sapiens_hsa045200.54047827
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53736447
95Ether lipid metabolism_Homo sapiens_hsa005650.52283417
96* Metabolic pathways_Homo sapiens_hsa011000.50643738
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.50274472
98MicroRNAs in cancer_Homo sapiens_hsa052060.49224137
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47581604
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45242240
101Cardiac muscle contraction_Homo sapiens_hsa042600.43022743
102Lysine degradation_Homo sapiens_hsa003100.42770023
103N-Glycan biosynthesis_Homo sapiens_hsa005100.42470229
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40648190
105Endocytosis_Homo sapiens_hsa041440.38878229
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38824570
107Fatty acid degradation_Homo sapiens_hsa000710.38023903
108Propanoate metabolism_Homo sapiens_hsa006400.33719098
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.33625302
110Pancreatic secretion_Homo sapiens_hsa049720.33214328
111Small cell lung cancer_Homo sapiens_hsa052220.33192313
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32472518
113Hedgehog signaling pathway_Homo sapiens_hsa043400.32165324
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31677244
115Phenylalanine metabolism_Homo sapiens_hsa003600.31184750
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30656550
117mTOR signaling pathway_Homo sapiens_hsa041500.29869401
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29785617
119Inositol phosphate metabolism_Homo sapiens_hsa005620.29602210
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28304822
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26194610
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25678363
123* Retinol metabolism_Homo sapiens_hsa008300.25201336
124Notch signaling pathway_Homo sapiens_hsa043300.24917867
125Caffeine metabolism_Homo sapiens_hsa002320.23169577
126Bladder cancer_Homo sapiens_hsa052190.23112212
127FoxO signaling pathway_Homo sapiens_hsa040680.19803810
128Protein digestion and absorption_Homo sapiens_hsa049740.19214575
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17153935
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16599629
131Other glycan degradation_Homo sapiens_hsa005110.14156636
132Vibrio cholerae infection_Homo sapiens_hsa051100.12655227
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12327672
134Renal cell carcinoma_Homo sapiens_hsa052110.12281652

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