CYP2T1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell morphogenesis involved in neuron differentiation (GO:0048667)9.21613679
2mechanosensory behavior (GO:0007638)7.62911910
3startle response (GO:0001964)7.13596219
4response to auditory stimulus (GO:0010996)6.47593836
5regulation of chromatin binding (GO:0035561)6.14645700
6male meiosis (GO:0007140)5.77056719
7innervation (GO:0060384)5.35951712
8positive regulation of keratinocyte differentiation (GO:0045618)5.32767584
9positive regulation of receptor recycling (GO:0001921)5.15332522
10glucocorticoid metabolic process (GO:0008211)5.02674197
11cochlea development (GO:0090102)4.92524677
12face development (GO:0060324)4.29672116
13reflex (GO:0060004)4.23025476
14microtubule anchoring (GO:0034453)4.20394476
15positive regulation of fatty acid beta-oxidation (GO:0032000)4.15394315
16lens development in camera-type eye (GO:0002088)4.08155995
17cranial nerve development (GO:0021545)3.97572061
18insulin-like growth factor receptor signaling pathway (GO:0048009)3.94406294
19mannose metabolic process (GO:0006013)3.87933716
20mitotic spindle assembly checkpoint (GO:0007094)3.85888571
21regulation of fatty acid beta-oxidation (GO:0031998)3.79668246
22regulation of histone H3-K27 methylation (GO:0061085)3.77031567
23spindle assembly checkpoint (GO:0071173)3.70797882
24epithelial cell maturation (GO:0002070)3.62648485
25erythrocyte maturation (GO:0043249)3.61233995
26negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.59157354
27carnitine transmembrane transport (GO:1902603)3.58720790
28neutrophil activation (GO:0042119)3.54072018
29regulation of histone deacetylation (GO:0031063)3.47428039
30regulation of interleukin-13 production (GO:0032656)3.43724209
31negative regulation of mitotic sister chromatid segregation (GO:0033048)3.39265277
32negative regulation of mitotic sister chromatid separation (GO:2000816)3.39265277
33negative regulation of sister chromatid segregation (GO:0033046)3.39265277
34negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.39265277
35negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.39265277
36positive regulation of epidermal cell differentiation (GO:0045606)3.38074697
37negative regulation of granulocyte differentiation (GO:0030853)3.36255686
38phosphatidylinositol 3-kinase signaling (GO:0014065)3.31531752
39glutathione biosynthetic process (GO:0006750)3.31488015
40negative regulation of chromosome segregation (GO:0051985)3.30815943
41positive regulation of insulin receptor signaling pathway (GO:0046628)3.28304214
42amino-acid betaine transport (GO:0015838)3.26367826
43carnitine transport (GO:0015879)3.26367826
44receptor recycling (GO:0001881)3.26286038
45actin filament polymerization (GO:0030041)3.24904341
46definitive hemopoiesis (GO:0060216)3.22380406
47regulation of glucose import in response to insulin stimulus (GO:2001273)3.21729220
48granulocyte activation (GO:0036230)3.16457488
49energy homeostasis (GO:0097009)3.11394952
50NLS-bearing protein import into nucleus (GO:0006607)3.11019336
51nonribosomal peptide biosynthetic process (GO:0019184)3.10885172
52mitotic spindle checkpoint (GO:0071174)3.08321716
53ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.00098535
54nucleoside bisphosphate biosynthetic process (GO:0033866)3.00098535
55purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.00098535
56negative regulation of erythrocyte differentiation (GO:0045647)2.99517518
57superoxide metabolic process (GO:0006801)2.88775294
58JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88694463
59regulation of receptor recycling (GO:0001919)2.86681833
60misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.85436352
61endosome organization (GO:0007032)2.85298743
62adenosine receptor signaling pathway (GO:0001973)2.83748021
63activation of protein kinase A activity (GO:0034199)2.83613930
64regulation of T-helper 2 cell differentiation (GO:0045628)2.82340700
65negative regulation of protein binding (GO:0032091)2.81575471
66cellular response to antibiotic (GO:0071236)2.80517916
67negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.79291342
68cellular response to estradiol stimulus (GO:0071392)2.78351548
69positive regulation of odontogenesis (GO:0042482)2.75862390
70histone H3-K9 demethylation (GO:0033169)2.75665729
71cellular response to estrogen stimulus (GO:0071391)2.73742993
72type B pancreatic cell proliferation (GO:0044342)2.70169295
73intracellular estrogen receptor signaling pathway (GO:0030520)2.68664082
74negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.65162979
75establishment of skin barrier (GO:0061436)2.63305314
76regulation of cytokinesis (GO:0032465)2.62943107
77regulation of water loss via skin (GO:0033561)2.62493701
78cellular zinc ion homeostasis (GO:0006882)2.60984339
79positive regulation of cellular response to insulin stimulus (GO:1900078)2.60196944
80quaternary ammonium group transport (GO:0015697)2.60005359
81regulation of granulocyte differentiation (GO:0030852)2.55869325
82response to parathyroid hormone (GO:0071107)2.55546871
83nerve development (GO:0021675)2.53854989
84regulation of protein deacetylation (GO:0090311)2.53839886
85hemoglobin metabolic process (GO:0020027)2.53375425
86negative regulation of DNA-templated transcription, elongation (GO:0032785)2.52805002
87ear development (GO:0043583)2.52788406
88folic acid transport (GO:0015884)2.52151446
89positive regulation of interleukin-4 production (GO:0032753)2.48929951
90regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.48477014
91spindle checkpoint (GO:0031577)2.48029200
92G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.47659416
93outflow tract septum morphogenesis (GO:0003148)2.46941600
94regulation of sister chromatid segregation (GO:0033045)2.46897117
95regulation of mitotic sister chromatid separation (GO:0010965)2.46897117
96regulation of mitotic sister chromatid segregation (GO:0033047)2.46897117
97positive regulation of urine volume (GO:0035810)2.46750422
98histamine secretion (GO:0001821)2.46591476
99auditory behavior (GO:0031223)11.1400333
100attachment of spindle microtubules to kinetochore (GO:0008608)10.3566236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human5.97855802
2ESR1_21235772_ChIP-Seq_MCF-7_Human4.55870449
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.33215207
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.86192952
5VDR_21846776_ChIP-Seq_THP-1_Human3.26777191
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.97252358
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.97252358
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.97252358
9SCL_19346495_ChIP-Seq_HPC-7_Human2.63431741
10TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.55408052
11RACK7_27058665_Chip-Seq_MCF-7_Human2.47742141
12RUNX1_27514584_Chip-Seq_MCF-7_Human2.38663570
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35620595
14LXR_22292898_ChIP-Seq_THP-1_Human2.33701730
15PKCTHETA_26484144_Chip-Seq_BREAST_Human2.30384127
16ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.21961408
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21178139
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21004598
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.12910610
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.08799517
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07779171
22TCF7_22412390_ChIP-Seq_EML_Mouse2.03307775
23VDR_24763502_ChIP-Seq_THP-1_Human2.00398237
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92440754
25TDRD3_21172665_ChIP-Seq_MCF-7_Human1.85717627
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84333940
27MYC_22102868_ChIP-Seq_BL_Human1.82358432
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81359960
29GATA1_19941826_ChIP-Seq_K562_Human1.70610858
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70382943
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67611520
32P68_20966046_ChIP-Seq_HELA_Human1.67512839
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.64658704
34NCOR1_26117541_ChIP-Seq_K562_Human1.61885375
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.60135872
36CREB1_26743006_Chip-Seq_LNCaP_Human1.58696999
37SMC4_20622854_ChIP-Seq_HELA_Human1.54135439
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53559925
39KDM2B_26808549_Chip-Seq_DND41_Human1.48996837
40ZNF263_19887448_ChIP-Seq_K562_Human1.47493999
41CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.46244523
42DROSHA_22980978_ChIP-Seq_HELA_Human1.46056164
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43609208
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38450130
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38252111
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36612700
47GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34350087
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33541937
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.33288071
50MAF_26560356_Chip-Seq_TH1_Human1.32108595
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30973384
52GATA3_24758297_ChIP-Seq_MCF-7_Human1.29622103
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29368918
54MAF_26560356_Chip-Seq_TH2_Human1.28714913
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28069289
56GATA2_19941826_ChIP-Seq_K562_Human1.27780580
57MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.26276466
58AHR_22903824_ChIP-Seq_MCF-7_Human1.24808231
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23817134
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22788495
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.21042241
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20752866
63BCOR_27268052_Chip-Seq_Bcells_Human1.19448063
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17603660
65PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17527432
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17224808
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16630946
68BCL6_27268052_Chip-Seq_Bcells_Human1.16293172
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14612738
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14546137
71ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14375754
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10994838
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.10427852
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08798220
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.07885063
76CIITA_25753668_ChIP-Seq_RAJI_Human1.07410843
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06499585
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05978416
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04306566
80CTCF_21964334_Chip-Seq_Bcells_Human1.03603441
81KDM2B_26808549_Chip-Seq_K562_Human1.03530819
82CTCF_26484167_Chip-Seq_Bcells_Mouse1.01801058
83RARB_24833708_ChIP-Seq_LIVER_Mouse1.00217527
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99133556
85GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98359291
86ELF5_23300383_ChIP-Seq_T47D_Human0.96809823
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95335757
88UTX_26944678_Chip-Seq_JUKART_Human0.94649519
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94609770
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94557077
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93479676
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92164993
93E2F1_20622854_ChIP-Seq_HELA_Human0.91980988
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.91653361
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91319143
96CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90759334
97STAT1_20625510_ChIP-Seq_HELA_Human0.90654991
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90589206
99KDM2B_26808549_Chip-Seq_JURKAT_Human0.89969743
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.89534175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.03248447
2MP0002009_preneoplasia3.83470670
3MP0009384_cardiac_valve_regurgitation3.64995849
4MP0004381_abnormal_hair_follicle3.31644482
5MP0005076_abnormal_cell_differentiation3.21628130
6MP0005058_abnormal_lysosome_morphology3.18499648
7MP0000013_abnormal_adipose_tissue3.02700824
8MP0001873_stomach_inflammation2.89213388
9MP0000537_abnormal_urethra_morphology2.86811554
10MP0005083_abnormal_biliary_tract2.69180031
11MP0003123_paternal_imprinting2.44013145
12MP0000678_abnormal_parathyroid_gland2.31200802
13MP0003136_yellow_coat_color2.29800633
14MP0003724_increased_susceptibility_to2.28971552
15MP0004782_abnormal_surfactant_physiolog2.28300901
16MP0004233_abnormal_muscle_weight2.15972486
17MP0008004_abnormal_stomach_pH1.84639582
18MP0001849_ear_inflammation1.83465545
19MP0001346_abnormal_lacrimal_gland1.78189813
20MP0005409_darkened_coat_color1.77461766
21MP0006082_CNS_inflammation1.76966460
22MP0005464_abnormal_platelet_physiology1.71150317
23MP0005666_abnormal_adipose_tissue1.68257754
24MP0002098_abnormal_vibrissa_morphology1.65940135
25MP0000681_abnormal_thyroid_gland1.64613321
26MP0002796_impaired_skin_barrier1.64330372
27MP0005248_abnormal_Harderian_gland1.60505067
28MP0003191_abnormal_cellular_cholesterol1.59657160
29MP0005375_adipose_tissue_phenotype1.57892365
30MP0003172_abnormal_lysosome_physiology1.56383550
31MP0000003_abnormal_adipose_tissue1.51966109
32MP0008995_early_reproductive_senescence1.45064792
33MP0003315_abnormal_perineum_morphology1.44658026
34MP0004808_abnormal_hematopoietic_stem1.43629823
35MP0004185_abnormal_adipocyte_glucose1.42139854
36MP0002127_abnormal_cardiovascular_syste1.34904774
37MP0002254_reproductive_system_inflammat1.34855138
38MP0005174_abnormal_tail_pigmentation1.34625828
39MP0002089_abnormal_postnatal_growth/wei1.32956729
40MP0001919_abnormal_reproductive_system1.29552347
41MP0003705_abnormal_hypodermis_morpholog1.28679379
42MP0005171_absent_coat_pigmentation1.25313565
43MP0003936_abnormal_reproductive_system1.24369597
44MP0000627_abnormal_mammary_gland1.23964286
45MP0003638_abnormal_response/metabolism_1.23818664
46MP0002160_abnormal_reproductive_system1.23629847
47MP0001881_abnormal_mammary_gland1.18861642
48MP0000427_abnormal_hair_cycle1.16043265
49MP0002282_abnormal_trachea_morphology1.13925366
50MP0009931_abnormal_skin_appearance1.13445792
51MP0009379_abnormal_foot_pigmentation1.11475638
52MP0000462_abnormal_digestive_system1.10751271
53MP0005075_abnormal_melanosome_morpholog1.09637755
54MP0001661_extended_life_span1.09056268
55MP0006138_congestive_heart_failure1.07341490
56MP0004883_abnormal_blood_vessel1.05253843
57MP0005501_abnormal_skin_physiology1.04439201
58MP0000470_abnormal_stomach_morphology1.03238260
59MP0001765_abnormal_ion_homeostasis1.02766210
60MP0008260_abnormal_autophagy1.02627043
61MP0005670_abnormal_white_adipose1.01493211
62MP0004043_abnormal_pH_regulation1.01224334
63MP0001502_abnormal_circadian_rhythm0.97605362
64MP0004510_myositis0.97359669
65MP0003942_abnormal_urinary_system0.96608674
66MP0002896_abnormal_bone_mineralization0.95350992
67MP0002184_abnormal_innervation0.94802924
68MP0000377_abnormal_hair_follicle0.94591944
69MP0005646_abnormal_pituitary_gland0.93882980
70MP0003656_abnormal_erythrocyte_physiolo0.90873487
71MP0002108_abnormal_muscle_morphology0.90660810
72MP0003453_abnormal_keratinocyte_physiol0.89622980
73MP0006276_abnormal_autonomic_nervous0.89225920
74MP0005503_abnormal_tendon_morphology0.88932216
75MP0000465_gastrointestinal_hemorrhage0.88313560
76MP0002132_abnormal_respiratory_system0.86826233
77MP0003943_abnormal_hepatobiliary_system0.86582562
78MP0005334_abnormal_fat_pad0.85207707
79MP0003300_gastrointestinal_ulcer0.84027731
80MP0000383_abnormal_hair_follicle0.83148247
81MP0005451_abnormal_body_composition0.82388081
82MP0005408_hypopigmentation0.80309719
83MP0002166_altered_tumor_susceptibility0.78547168
84MP0000767_abnormal_smooth_muscle0.77921056
85MP0002249_abnormal_larynx_morphology0.77723468
86MP0001177_atelectasis0.75689307
87MP0003828_pulmonary_edema0.70254632
88MP0009840_abnormal_foam_cell0.70195781
89MP0010155_abnormal_intestine_physiology0.70186114
90MP0002909_abnormal_adrenal_gland0.70087299
91MP0002653_abnormal_ependyma_morphology0.69274892
92MP0002086_abnormal_extraembryonic_tissu0.67916082
93MP0000613_abnormal_salivary_gland0.67800814
94MP0001756_abnormal_urination0.66764988
95MP0005636_abnormal_mineral_homeostasis0.64999167
96MP0000538_abnormal_urinary_bladder0.64559088
97MP0003279_aneurysm0.63304380
98MP0000026_abnormal_inner_ear0.62965016
99MP0000163_abnormal_cartilage_morphology0.61736086
100MP0003183_abnormal_peptide_metabolism0.61657967

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)7.68784838
2Severe Myopia (HP:0011003)7.54351930
3Sparse lateral eyebrow (HP:0005338)6.87345023
4Cervical subluxation (HP:0003308)4.25159890
5Flat capital femoral epiphysis (HP:0003370)4.19439610
6Abnormality of nail color (HP:0100643)4.14739514
7Testicular atrophy (HP:0000029)4.12500569
8Mucopolysacchariduria (HP:0008155)3.92452724
9Urinary glycosaminoglycan excretion (HP:0003541)3.92452724
10Abnormality of the proximal phalanges of the hand (HP:0009834)3.73982519
11Short 1st metacarpal (HP:0010034)3.68773945
12Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.68773945
13Dysostosis multiplex (HP:0000943)3.65251523
14Abnormality of polysaccharide metabolism (HP:0011012)3.57547599
15Abnormality of glycosaminoglycan metabolism (HP:0004371)3.57547599
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.57547599
17J-shaped sella turcica (HP:0002680)3.53546930
18Exostoses (HP:0100777)3.49988527
19Lip pit (HP:0100267)3.47222485
20Abnormality of the 1st metacarpal (HP:0010009)3.23759862
21Increased number of teeth (HP:0011069)3.23700793
22Deep philtrum (HP:0002002)3.20176781
23Menorrhagia (HP:0000132)3.10606738
24Broad face (HP:0000283)2.99657645
25Hand muscle atrophy (HP:0009130)2.80564252
26Prolonged bleeding time (HP:0003010)2.77138008
27Infantile muscular hypotonia (HP:0008947)2.75179128
28Loss of speech (HP:0002371)2.73920335
29Intestinal fistula (HP:0100819)2.71532891
30Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.61712911
31Distal upper limb amyotrophy (HP:0007149)2.56728688
32Upper limb amyotrophy (HP:0009129)2.56728688
33Colitis (HP:0002583)2.54431916
34Abnormality of the distal phalanges of the toes (HP:0010182)2.52908802
35Smooth philtrum (HP:0000319)2.50133619
36Pseudobulbar signs (HP:0002200)2.49906879
37Vaginal fistula (HP:0004320)2.49502953
38Genetic anticipation (HP:0003743)2.49149527
39Biconcave vertebral bodies (HP:0004586)2.45737898
40Rectal fistula (HP:0100590)2.42752342
41Rectovaginal fistula (HP:0000143)2.42752342
42Testicular neoplasm (HP:0010788)2.42434264
43Dyschromatopsia (HP:0007641)2.41921295
44Male infertility (HP:0003251)2.40598384
45Right ventricular cardiomyopathy (HP:0011663)2.37671975
46Microretrognathia (HP:0000308)2.36253134
47Joint stiffness (HP:0001387)2.34544136
48Septate vagina (HP:0001153)2.26874448
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.25609114
50Obstructive sleep apnea (HP:0002870)2.24967976
51Ulnar bowing (HP:0003031)2.20349372
52Abnormality of the lower motor neuron (HP:0002366)2.20324350
53Hypercortisolism (HP:0001578)2.20172648
54Short phalanx of the thumb (HP:0009660)2.19606994
55Interstitial pulmonary disease (HP:0006530)2.14643100
56Flat acetabular roof (HP:0003180)2.13921943
57Truncal obesity (HP:0001956)2.09415375
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.09088352
59Growth hormone excess (HP:0000845)2.08101637
60Achilles tendon contracture (HP:0001771)2.01886484
61Annular pancreas (HP:0001734)2.01720477
62Aplasia of the musculature (HP:0100854)2.01453617
63Stenosis of the external auditory canal (HP:0000402)1.98966473
64Abnormality of the Achilles tendon (HP:0005109)1.98491077
65Abnormality of the fingertips (HP:0001211)1.98438424
66Rib fusion (HP:0000902)1.97679714
67Abnormality of the femoral head (HP:0003368)1.95723728
68Acute lymphatic leukemia (HP:0006721)1.95508695
69Upper motor neuron abnormality (HP:0002127)1.95340220
70Accelerated skeletal maturation (HP:0005616)1.94667278
71Distal lower limb muscle weakness (HP:0009053)1.93804075
72EMG: neuropathic changes (HP:0003445)1.90454466
73Facial hemangioma (HP:0000329)1.90136109
74Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.90129991
75Abnormal tarsal ossification (HP:0008369)1.89811413
76Short clavicles (HP:0000894)1.85528122
77Dyskinesia (HP:0100660)1.84908936
78Mitral regurgitation (HP:0001653)1.84749461
79Bone pain (HP:0002653)1.84173926
80Abnormality of the corticospinal tract (HP:0002492)1.83980291
81Thin bony cortex (HP:0002753)1.82179233
82Deformed sella turcica (HP:0002681)1.80826075
83Asymmetric septal hypertrophy (HP:0001670)1.80725444
84Seborrheic dermatitis (HP:0001051)1.78629549
85Capillary hemangiomas (HP:0005306)1.78562464
86Abnormality of the renal collecting system (HP:0004742)1.77392639
87Increased cerebral lipofuscin (HP:0011813)1.77092718
88Flared iliac wings (HP:0002869)1.74981688
89Anteriorly placed anus (HP:0001545)1.74830433
90Increased mean platelet volume (HP:0011877)1.74691159
91Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.74378745
92Neuronal loss in central nervous system (HP:0002529)1.74017235
93Partial duplication of thumb phalanx (HP:0009944)1.73602863
94Cerebral palsy (HP:0100021)1.73023214
95Hypoparathyroidism (HP:0000829)1.72410070
96Abnormality of the epiphyses of the hand (HP:0005924)1.71825980
97Down-sloping shoulders (HP:0200021)1.69380883
98Abnormal platelet volume (HP:0011876)1.69178695
99Gastrointestinal inflammation (HP:0004386)1.68685060
100Panhypogammaglobulinemia (HP:0003139)1.68392203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK17.72697891
2RIPK43.59795687
3TRIB33.54760855
4SCYL23.16623334
5MUSK2.93494980
6CDK122.63540569
7EIF2AK12.63106375
8GRK62.63000578
9NME22.26669464
10CSF1R1.87855797
11PKN21.76463780
12MAPKAPK31.72723651
13MAPK151.66504027
14TNK21.60351063
15TAOK31.55133884
16BRD41.51853185
17EIF2AK21.49723473
18PRKD31.49464510
19MAP2K31.45687763
20RPS6KB21.34158628
21HIPK21.33687276
22TEC1.30712573
23NME11.29846005
24BTK1.24180410
25JAK11.10420023
26SMG11.08689670
27CDK71.08608965
28ZAP701.07309278
29BMPR21.05043730
30ERN11.03380806
31FER1.03355961
32ICK0.98298002
33RPS6KC10.96185557
34RPS6KL10.96185557
35SYK0.95231400
36MTOR0.93673102
37PRPF4B0.91080767
38TESK20.86312000
39STK380.85293420
40CHUK0.83963232
41RPS6KB10.82850557
42RPS6KA60.82376327
43IRAK30.81764610
44MAP2K10.81624844
45RPS6KA20.80215381
46BLK0.79994529
47MAP2K20.77082828
48RET0.72987372
49PLK10.72334918
50ADRBK10.72158850
51KSR20.71560605
52LRRK20.71155101
53EEF2K0.69730475
54JAK20.68793623
55SIK20.68677451
56PDPK10.65770188
57PRKD20.60345372
58PRKD10.59961232
59EPHA30.59776339
60CDC42BPA0.59275143
61ITK0.57814304
62MAPK110.57805252
63BMX0.57271977
64ADRBK20.57071628
65MAP3K30.56999139
66MAPK100.56879659
67PRKAA10.55834437
68WNK10.55545561
69MAP3K10.54291470
70SGK30.54125973
71BMPR1B0.52388996
72STK40.52332069
73MAP2K60.51102525
74TAOK10.50781201
75PTK20.49923349
76GRK10.49881570
77DYRK1B0.47875251
78FGFR40.47640882
79IKBKB0.47629550
80PTK60.47147161
81YES10.46863394
82EPHB10.46409730
83MAP3K60.45671066
84PIM20.43644950
85HCK0.42619906
86SIK30.41627304
87RPS6KA10.41503241
88MAPK30.41390222
89MAP3K20.39452306
90ILK0.38508435
91MAPK120.37465601
92RAF10.35937591
93IKBKE0.33556666
94MAPK40.33293212
95CAMK1D0.32267364
96MARK20.31840114
97TYRO30.31583824
98PRKAA20.30501402
99SGK20.30355540
100PDK10.30179032

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.70655860
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.64717604
3Other glycan degradation_Homo sapiens_hsa005112.93562453
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.92090839
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.25838974
6mTOR signaling pathway_Homo sapiens_hsa041502.11364675
7Acute myeloid leukemia_Homo sapiens_hsa052211.92696938
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.91963107
9Platelet activation_Homo sapiens_hsa046111.77192916
10B cell receptor signaling pathway_Homo sapiens_hsa046621.65892778
11Sulfur relay system_Homo sapiens_hsa041221.53671787
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53365358
13Sphingolipid metabolism_Homo sapiens_hsa006001.50435080
14VEGF signaling pathway_Homo sapiens_hsa043701.50193221
15Longevity regulating pathway - mammal_Homo sapiens_hsa042111.49940849
16Fructose and mannose metabolism_Homo sapiens_hsa000511.49042119
17Choline metabolism in cancer_Homo sapiens_hsa052311.45373948
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.44381760
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35314836
20Insulin signaling pathway_Homo sapiens_hsa049101.30197620
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28626142
22Endometrial cancer_Homo sapiens_hsa052131.25910877
23Chronic myeloid leukemia_Homo sapiens_hsa052201.25887425
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.25264863
25Insulin resistance_Homo sapiens_hsa049311.24980870
26AMPK signaling pathway_Homo sapiens_hsa041521.21950797
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.21129592
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19946461
29Thyroid cancer_Homo sapiens_hsa052161.18493893
30Lysosome_Homo sapiens_hsa041421.18468679
31Vitamin digestion and absorption_Homo sapiens_hsa049771.16649272
32Ovarian steroidogenesis_Homo sapiens_hsa049131.16289606
33Non-small cell lung cancer_Homo sapiens_hsa052231.16000937
34HIF-1 signaling pathway_Homo sapiens_hsa040661.13495207
35Hepatitis C_Homo sapiens_hsa051601.11870570
36Fatty acid biosynthesis_Homo sapiens_hsa000611.11799888
37Notch signaling pathway_Homo sapiens_hsa043301.11660750
38Prolactin signaling pathway_Homo sapiens_hsa049171.11505346
39Lysine degradation_Homo sapiens_hsa003101.11125555
40Endocytosis_Homo sapiens_hsa041441.10995024
41Type II diabetes mellitus_Homo sapiens_hsa049301.06917208
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06561078
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04632420
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02425175
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02082682
46Inositol phosphate metabolism_Homo sapiens_hsa005620.99963188
47Chemokine signaling pathway_Homo sapiens_hsa040620.99665008
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94373659
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.93911500
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.91063340
51ErbB signaling pathway_Homo sapiens_hsa040120.90374085
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89898072
53Estrogen signaling pathway_Homo sapiens_hsa049150.89589652
54Pancreatic cancer_Homo sapiens_hsa052120.86383245
55Sulfur metabolism_Homo sapiens_hsa009200.85522783
56Renal cell carcinoma_Homo sapiens_hsa052110.80721301
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.79705755
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.77375768
59Osteoclast differentiation_Homo sapiens_hsa043800.77100726
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76799172
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.76743894
62Prostate cancer_Homo sapiens_hsa052150.74736282
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73902363
64Gap junction_Homo sapiens_hsa045400.73633127
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.73454196
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72275797
67T cell receptor signaling pathway_Homo sapiens_hsa046600.70796984
68ABC transporters_Homo sapiens_hsa020100.70191021
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68004402
70Viral carcinogenesis_Homo sapiens_hsa052030.67230157
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65703254
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65329922
73Amoebiasis_Homo sapiens_hsa051460.64991264
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63664120
75N-Glycan biosynthesis_Homo sapiens_hsa005100.62777351
76Olfactory transduction_Homo sapiens_hsa047400.60794590
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57898430
78GnRH signaling pathway_Homo sapiens_hsa049120.54674069
79Colorectal cancer_Homo sapiens_hsa052100.54533847
80Bladder cancer_Homo sapiens_hsa052190.52855062
81Alcoholism_Homo sapiens_hsa050340.52637314
82Glioma_Homo sapiens_hsa052140.51556627
83Hepatitis B_Homo sapiens_hsa051610.49932361
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49339211
85Nitrogen metabolism_Homo sapiens_hsa009100.48809597
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48632923
87Circadian rhythm_Homo sapiens_hsa047100.47169940
88MAPK signaling pathway_Homo sapiens_hsa040100.45569395
89Taste transduction_Homo sapiens_hsa047420.44891824
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43956030
91Melanogenesis_Homo sapiens_hsa049160.41035999
92Malaria_Homo sapiens_hsa051440.40312782
93FoxO signaling pathway_Homo sapiens_hsa040680.40118774
94Focal adhesion_Homo sapiens_hsa045100.39656778
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.39101947
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39054082
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38445915
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38426051
99Proteoglycans in cancer_Homo sapiens_hsa052050.37712924
100MicroRNAs in cancer_Homo sapiens_hsa052060.37454688

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