ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell morphogenesis involved in neuron differentiation (GO:0048667)	9.21613679
2	mechanosensory behavior (GO:0007638)	7.62911910
3	startle response (GO:0001964)	7.13596219
4	response to auditory stimulus (GO:0010996)	6.47593836
5	regulation of chromatin binding (GO:0035561)	6.14645700
6	male meiosis (GO:0007140)	5.77056719
7	innervation (GO:0060384)	5.35951712
8	positive regulation of keratinocyte differentiation (GO:0045618)	5.32767584
9	positive regulation of receptor recycling (GO:0001921)	5.15332522
10	glucocorticoid metabolic process (GO:0008211)	5.02674197
11	cochlea development (GO:0090102)	4.92524677
12	face development (GO:0060324)	4.29672116
13	reflex (GO:0060004)	4.23025476
14	microtubule anchoring (GO:0034453)	4.20394476
15	positive regulation of fatty acid beta-oxidation (GO:0032000)	4.15394315
16	lens development in camera-type eye (GO:0002088)	4.08155995
17	cranial nerve development (GO:0021545)	3.97572061
18	insulin-like growth factor receptor signaling pathway (GO:0048009)	3.94406294
19	mannose metabolic process (GO:0006013)	3.87933716
20	mitotic spindle assembly checkpoint (GO:0007094)	3.85888571
21	regulation of fatty acid beta-oxidation (GO:0031998)	3.79668246
22	regulation of histone H3-K27 methylation (GO:0061085)	3.77031567
23	spindle assembly checkpoint (GO:0071173)	3.70797882
24	epithelial cell maturation (GO:0002070)	3.62648485
25	erythrocyte maturation (GO:0043249)	3.61233995
26	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	3.59157354
27	carnitine transmembrane transport (GO:1902603)	3.58720790
28	neutrophil activation (GO:0042119)	3.54072018
29	regulation of histone deacetylation (GO:0031063)	3.47428039
30	regulation of interleukin-13 production (GO:0032656)	3.43724209
31	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.39265277
32	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.39265277
33	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.39265277
34	negative regulation of sister chromatid segregation (GO:0033046)	3.39265277
35	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.39265277
36	positive regulation of epidermal cell differentiation (GO:0045606)	3.38074697
37	negative regulation of granulocyte differentiation (GO:0030853)	3.36255686
38	phosphatidylinositol 3-kinase signaling (GO:0014065)	3.31531752
39	glutathione biosynthetic process (GO:0006750)	3.31488015
40	negative regulation of chromosome segregation (GO:0051985)	3.30815943
41	positive regulation of insulin receptor signaling pathway (GO:0046628)	3.28304214
42	amino-acid betaine transport (GO:0015838)	3.26367826
43	carnitine transport (GO:0015879)	3.26367826
44	receptor recycling (GO:0001881)	3.26286038
45	actin filament polymerization (GO:0030041)	3.24904341
46	definitive hemopoiesis (GO:0060216)	3.22380406
47	regulation of glucose import in response to insulin stimulus (GO:2001273)	3.21729220
48	granulocyte activation (GO:0036230)	3.16457488
49	energy homeostasis (GO:0097009)	3.11394952
50	NLS-bearing protein import into nucleus (GO:0006607)	3.11019336
51	nonribosomal peptide biosynthetic process (GO:0019184)	3.10885172
52	mitotic spindle checkpoint (GO:0071174)	3.08321716
53	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.00098535
54	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.00098535
55	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.00098535
56	negative regulation of erythrocyte differentiation (GO:0045647)	2.99517518
57	superoxide metabolic process (GO:0006801)	2.88775294
58	JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)	2.88694463
59	regulation of receptor recycling (GO:0001919)	2.86681833
60	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.85436352
61	endosome organization (GO:0007032)	2.85298743
62	adenosine receptor signaling pathway (GO:0001973)	2.83748021
63	activation of protein kinase A activity (GO:0034199)	2.83613930
64	regulation of T-helper 2 cell differentiation (GO:0045628)	2.82340700
65	negative regulation of protein binding (GO:0032091)	2.81575471
66	cellular response to antibiotic (GO:0071236)	2.80517916
67	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.79291342
68	cellular response to estradiol stimulus (GO:0071392)	2.78351548
69	positive regulation of odontogenesis (GO:0042482)	2.75862390
70	histone H3-K9 demethylation (GO:0033169)	2.75665729
71	cellular response to estrogen stimulus (GO:0071391)	2.73742993
72	type B pancreatic cell proliferation (GO:0044342)	2.70169295
73	intracellular estrogen receptor signaling pathway (GO:0030520)	2.68664082
74	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.65162979
75	establishment of skin barrier (GO:0061436)	2.63305314
76	regulation of cytokinesis (GO:0032465)	2.62943107
77	regulation of water loss via skin (GO:0033561)	2.62493701
78	cellular zinc ion homeostasis (GO:0006882)	2.60984339
79	positive regulation of cellular response to insulin stimulus (GO:1900078)	2.60196944
80	quaternary ammonium group transport (GO:0015697)	2.60005359
81	regulation of granulocyte differentiation (GO:0030852)	2.55869325
82	response to parathyroid hormone (GO:0071107)	2.55546871
83	nerve development (GO:0021675)	2.53854989
84	regulation of protein deacetylation (GO:0090311)	2.53839886
85	hemoglobin metabolic process (GO:0020027)	2.53375425
86	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.52805002
87	ear development (GO:0043583)	2.52788406
88	folic acid transport (GO:0015884)	2.52151446
89	positive regulation of interleukin-4 production (GO:0032753)	2.48929951
90	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.48477014
91	spindle checkpoint (GO:0031577)	2.48029200
92	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.47659416
93	outflow tract septum morphogenesis (GO:0003148)	2.46941600
94	regulation of sister chromatid segregation (GO:0033045)	2.46897117
95	regulation of mitotic sister chromatid separation (GO:0010965)	2.46897117
96	regulation of mitotic sister chromatid segregation (GO:0033047)	2.46897117
97	positive regulation of urine volume (GO:0035810)	2.46750422
98	histamine secretion (GO:0001821)	2.46591476
99	auditory behavior (GO:0031223)	11.1400333
100	attachment of spindle microtubules to kinetochore (GO:0008608)	10.3566236

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_20079471_ChIP-ChIP_T-47D_Human	5.97855802
2	ESR1_21235772_ChIP-Seq_MCF-7_Human	4.55870449
3	STAT6_21828071_ChIP-Seq_BEAS2B_Human	4.33215207
4	ESR2_21235772_ChIP-Seq_MCF-7_Human	3.86192952
5	VDR_21846776_ChIP-Seq_THP-1_Human	3.26777191
6	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.97252358
7	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.97252358
8	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.97252358
9	SCL_19346495_ChIP-Seq_HPC-7_Human	2.63431741
10	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.55408052
11	RACK7_27058665_Chip-Seq_MCF-7_Human	2.47742141
12	RUNX1_27514584_Chip-Seq_MCF-7_Human	2.38663570
13	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.35620595
14	LXR_22292898_ChIP-Seq_THP-1_Human	2.33701730
15	PKCTHETA_26484144_Chip-Seq_BREAST_Human	2.30384127
16	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.21961408
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.21178139
18	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.21004598
19	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.12910610
20	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.08799517
21	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.07779171
22	TCF7_22412390_ChIP-Seq_EML_Mouse	2.03307775
23	VDR_24763502_ChIP-Seq_THP-1_Human	2.00398237
24	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.92440754
25	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.85717627
26	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.84333940
27	MYC_22102868_ChIP-Seq_BL_Human	1.82358432
28	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.81359960
29	GATA1_19941826_ChIP-Seq_K562_Human	1.70610858
30	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.70382943
31	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.67611520
32	P68_20966046_ChIP-Seq_HELA_Human	1.67512839
33	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.64658704
34	NCOR1_26117541_ChIP-Seq_K562_Human	1.61885375
35	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.60135872
36	CREB1_26743006_Chip-Seq_LNCaP_Human	1.58696999
37	SMC4_20622854_ChIP-Seq_HELA_Human	1.54135439
38	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.53559925
39	KDM2B_26808549_Chip-Seq_DND41_Human	1.48996837
40	ZNF263_19887448_ChIP-Seq_K562_Human	1.47493999
41	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.46244523
42	DROSHA_22980978_ChIP-Seq_HELA_Human	1.46056164
43	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.43609208
44	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.38450130
45	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.38252111
46	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.36612700
47	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.34350087
48	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.33541937
49	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.33288071
50	MAF_26560356_Chip-Seq_TH1_Human	1.32108595
51	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.30973384
52	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.29622103
53	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.29368918
54	MAF_26560356_Chip-Seq_TH2_Human	1.28714913
55	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.28069289
56	GATA2_19941826_ChIP-Seq_K562_Human	1.27780580
57	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.26276466
58	AHR_22903824_ChIP-Seq_MCF-7_Human	1.24808231
59	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.23817134
60	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.22788495
61	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.21042241
62	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.20752866
63	BCOR_27268052_Chip-Seq_Bcells_Human	1.19448063
64	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.17603660
65	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.17527432
66	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.17224808
67	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.16630946
68	BCL6_27268052_Chip-Seq_Bcells_Human	1.16293172
69	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.14612738
70	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.14546137
71	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.14375754
72	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.10994838
73	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.10427852
74	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.08798220
75	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.07885063
76	CIITA_25753668_ChIP-Seq_RAJI_Human	1.07410843
77	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.06499585
78	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.05978416
79	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.04306566
80	CTCF_21964334_Chip-Seq_Bcells_Human	1.03603441
81	KDM2B_26808549_Chip-Seq_K562_Human	1.03530819
82	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.01801058
83	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.00217527
84	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.99133556
85	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.98359291
86	ELF5_23300383_ChIP-Seq_T47D_Human	0.96809823
87	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95335757
88	UTX_26944678_Chip-Seq_JUKART_Human	0.94649519
89	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.94609770
90	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.94557077
91	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93479676
92	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.92164993
93	E2F1_20622854_ChIP-Seq_HELA_Human	0.91980988
94	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.91653361
95	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.91319143
96	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.90759334
97	STAT1_20625510_ChIP-Seq_HELA_Human	0.90654991
98	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.90589206
99	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.89969743
100	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.89534175

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004264_abnormal_extraembryonic_tissu	4.03248447
2	MP0002009_preneoplasia	3.83470670
3	MP0009384_cardiac_valve_regurgitation	3.64995849
4	MP0004381_abnormal_hair_follicle	3.31644482
5	MP0005076_abnormal_cell_differentiation	3.21628130
6	MP0005058_abnormal_lysosome_morphology	3.18499648
7	MP0000013_abnormal_adipose_tissue	3.02700824
8	MP0001873_stomach_inflammation	2.89213388
9	MP0000537_abnormal_urethra_morphology	2.86811554
10	MP0005083_abnormal_biliary_tract	2.69180031
11	MP0003123_paternal_imprinting	2.44013145
12	MP0000678_abnormal_parathyroid_gland	2.31200802
13	MP0003136_yellow_coat_color	2.29800633
14	MP0003724_increased_susceptibility_to	2.28971552
15	MP0004782_abnormal_surfactant_physiolog	2.28300901
16	MP0004233_abnormal_muscle_weight	2.15972486
17	MP0008004_abnormal_stomach_pH	1.84639582
18	MP0001849_ear_inflammation	1.83465545
19	MP0001346_abnormal_lacrimal_gland	1.78189813
20	MP0005409_darkened_coat_color	1.77461766
21	MP0006082_CNS_inflammation	1.76966460
22	MP0005464_abnormal_platelet_physiology	1.71150317
23	MP0005666_abnormal_adipose_tissue	1.68257754
24	MP0002098_abnormal_vibrissa_morphology	1.65940135
25	MP0000681_abnormal_thyroid_gland	1.64613321
26	MP0002796_impaired_skin_barrier	1.64330372
27	MP0005248_abnormal_Harderian_gland	1.60505067
28	MP0003191_abnormal_cellular_cholesterol	1.59657160
29	MP0005375_adipose_tissue_phenotype	1.57892365
30	MP0003172_abnormal_lysosome_physiology	1.56383550
31	MP0000003_abnormal_adipose_tissue	1.51966109
32	MP0008995_early_reproductive_senescence	1.45064792
33	MP0003315_abnormal_perineum_morphology	1.44658026
34	MP0004808_abnormal_hematopoietic_stem	1.43629823
35	MP0004185_abnormal_adipocyte_glucose	1.42139854
36	MP0002127_abnormal_cardiovascular_syste	1.34904774
37	MP0002254_reproductive_system_inflammat	1.34855138
38	MP0005174_abnormal_tail_pigmentation	1.34625828
39	MP0002089_abnormal_postnatal_growth/wei	1.32956729
40	MP0001919_abnormal_reproductive_system	1.29552347
41	MP0003705_abnormal_hypodermis_morpholog	1.28679379
42	MP0005171_absent_coat_pigmentation	1.25313565
43	MP0003936_abnormal_reproductive_system	1.24369597
44	MP0000627_abnormal_mammary_gland	1.23964286
45	MP0003638_abnormal_response/metabolism_	1.23818664
46	MP0002160_abnormal_reproductive_system	1.23629847
47	MP0001881_abnormal_mammary_gland	1.18861642
48	MP0000427_abnormal_hair_cycle	1.16043265
49	MP0002282_abnormal_trachea_morphology	1.13925366
50	MP0009931_abnormal_skin_appearance	1.13445792
51	MP0009379_abnormal_foot_pigmentation	1.11475638
52	MP0000462_abnormal_digestive_system	1.10751271
53	MP0005075_abnormal_melanosome_morpholog	1.09637755
54	MP0001661_extended_life_span	1.09056268
55	MP0006138_congestive_heart_failure	1.07341490
56	MP0004883_abnormal_blood_vessel	1.05253843
57	MP0005501_abnormal_skin_physiology	1.04439201
58	MP0000470_abnormal_stomach_morphology	1.03238260
59	MP0001765_abnormal_ion_homeostasis	1.02766210
60	MP0008260_abnormal_autophagy	1.02627043
61	MP0005670_abnormal_white_adipose	1.01493211
62	MP0004043_abnormal_pH_regulation	1.01224334
63	MP0001502_abnormal_circadian_rhythm	0.97605362
64	MP0004510_myositis	0.97359669
65	MP0003942_abnormal_urinary_system	0.96608674
66	MP0002896_abnormal_bone_mineralization	0.95350992
67	MP0002184_abnormal_innervation	0.94802924
68	MP0000377_abnormal_hair_follicle	0.94591944
69	MP0005646_abnormal_pituitary_gland	0.93882980
70	MP0003656_abnormal_erythrocyte_physiolo	0.90873487
71	MP0002108_abnormal_muscle_morphology	0.90660810
72	MP0003453_abnormal_keratinocyte_physiol	0.89622980
73	MP0006276_abnormal_autonomic_nervous	0.89225920
74	MP0005503_abnormal_tendon_morphology	0.88932216
75	MP0000465_gastrointestinal_hemorrhage	0.88313560
76	MP0002132_abnormal_respiratory_system	0.86826233
77	MP0003943_abnormal_hepatobiliary_system	0.86582562
78	MP0005334_abnormal_fat_pad	0.85207707
79	MP0003300_gastrointestinal_ulcer	0.84027731
80	MP0000383_abnormal_hair_follicle	0.83148247
81	MP0005451_abnormal_body_composition	0.82388081
82	MP0005408_hypopigmentation	0.80309719
83	MP0002166_altered_tumor_susceptibility	0.78547168
84	MP0000767_abnormal_smooth_muscle	0.77921056
85	MP0002249_abnormal_larynx_morphology	0.77723468
86	MP0001177_atelectasis	0.75689307
87	MP0003828_pulmonary_edema	0.70254632
88	MP0009840_abnormal_foam_cell	0.70195781
89	MP0010155_abnormal_intestine_physiology	0.70186114
90	MP0002909_abnormal_adrenal_gland	0.70087299
91	MP0002653_abnormal_ependyma_morphology	0.69274892
92	MP0002086_abnormal_extraembryonic_tissu	0.67916082
93	MP0000613_abnormal_salivary_gland	0.67800814
94	MP0001756_abnormal_urination	0.66764988
95	MP0005636_abnormal_mineral_homeostasis	0.64999167
96	MP0000538_abnormal_urinary_bladder	0.64559088
97	MP0003279_aneurysm	0.63304380
98	MP0000026_abnormal_inner_ear	0.62965016
99	MP0000163_abnormal_cartilage_morphology	0.61736086
100	MP0003183_abnormal_peptide_metabolism	0.61657967

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Concave nail (HP:0001598)	7.68784838
2	Severe Myopia (HP:0011003)	7.54351930
3	Sparse lateral eyebrow (HP:0005338)	6.87345023
4	Cervical subluxation (HP:0003308)	4.25159890
5	Flat capital femoral epiphysis (HP:0003370)	4.19439610
6	Abnormality of nail color (HP:0100643)	4.14739514
7	Testicular atrophy (HP:0000029)	4.12500569
8	Mucopolysacchariduria (HP:0008155)	3.92452724
9	Urinary glycosaminoglycan excretion (HP:0003541)	3.92452724
10	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.73982519
11	Short 1st metacarpal (HP:0010034)	3.68773945
12	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.68773945
13	Dysostosis multiplex (HP:0000943)	3.65251523
14	Abnormality of mucopolysaccharide metabolism (HP:0011020)	3.57547599
15	Abnormality of polysaccharide metabolism (HP:0011012)	3.57547599
16	Abnormality of glycosaminoglycan metabolism (HP:0004371)	3.57547599
17	J-shaped sella turcica (HP:0002680)	3.53546930
18	Exostoses (HP:0100777)	3.49988527
19	Lip pit (HP:0100267)	3.47222485
20	Abnormality of the 1st metacarpal (HP:0010009)	3.23759862
21	Increased number of teeth (HP:0011069)	3.23700793
22	Deep philtrum (HP:0002002)	3.20176781
23	Menorrhagia (HP:0000132)	3.10606738
24	Broad face (HP:0000283)	2.99657645
25	Hand muscle atrophy (HP:0009130)	2.80564252
26	Prolonged bleeding time (HP:0003010)	2.77138008
27	Infantile muscular hypotonia (HP:0008947)	2.75179128
28	Loss of speech (HP:0002371)	2.73920335
29	Intestinal fistula (HP:0100819)	2.71532891
30	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.61712911
31	Upper limb amyotrophy (HP:0009129)	2.56728688
32	Distal upper limb amyotrophy (HP:0007149)	2.56728688
33	Colitis (HP:0002583)	2.54431916
34	Abnormality of the distal phalanges of the toes (HP:0010182)	2.52908802
35	Smooth philtrum (HP:0000319)	2.50133619
36	Pseudobulbar signs (HP:0002200)	2.49906879
37	Vaginal fistula (HP:0004320)	2.49502953
38	Genetic anticipation (HP:0003743)	2.49149527
39	Biconcave vertebral bodies (HP:0004586)	2.45737898
40	Rectal fistula (HP:0100590)	2.42752342
41	Rectovaginal fistula (HP:0000143)	2.42752342
42	Testicular neoplasm (HP:0010788)	2.42434264
43	Dyschromatopsia (HP:0007641)	2.41921295
44	Male infertility (HP:0003251)	2.40598384
45	Right ventricular cardiomyopathy (HP:0011663)	2.37671975
46	Microretrognathia (HP:0000308)	2.36253134
47	Joint stiffness (HP:0001387)	2.34544136
48	Septate vagina (HP:0001153)	2.26874448
49	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.25609114
50	Obstructive sleep apnea (HP:0002870)	2.24967976
51	Ulnar bowing (HP:0003031)	2.20349372
52	Abnormality of the lower motor neuron (HP:0002366)	2.20324350
53	Hypercortisolism (HP:0001578)	2.20172648
54	Short phalanx of the thumb (HP:0009660)	2.19606994
55	Interstitial pulmonary disease (HP:0006530)	2.14643100
56	Flat acetabular roof (HP:0003180)	2.13921943
57	Truncal obesity (HP:0001956)	2.09415375
58	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.09088352
59	Growth hormone excess (HP:0000845)	2.08101637
60	Achilles tendon contracture (HP:0001771)	2.01886484
61	Annular pancreas (HP:0001734)	2.01720477
62	Aplasia of the musculature (HP:0100854)	2.01453617
63	Stenosis of the external auditory canal (HP:0000402)	1.98966473
64	Abnormality of the Achilles tendon (HP:0005109)	1.98491077
65	Abnormality of the fingertips (HP:0001211)	1.98438424
66	Rib fusion (HP:0000902)	1.97679714
67	Abnormality of the femoral head (HP:0003368)	1.95723728
68	Acute lymphatic leukemia (HP:0006721)	1.95508695
69	Upper motor neuron abnormality (HP:0002127)	1.95340220
70	Accelerated skeletal maturation (HP:0005616)	1.94667278
71	Distal lower limb muscle weakness (HP:0009053)	1.93804075
72	EMG: neuropathic changes (HP:0003445)	1.90454466
73	Facial hemangioma (HP:0000329)	1.90136109
74	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.90129991
75	Abnormal tarsal ossification (HP:0008369)	1.89811413
76	Short clavicles (HP:0000894)	1.85528122
77	Dyskinesia (HP:0100660)	1.84908936
78	Mitral regurgitation (HP:0001653)	1.84749461
79	Bone pain (HP:0002653)	1.84173926
80	Abnormality of the corticospinal tract (HP:0002492)	1.83980291
81	Thin bony cortex (HP:0002753)	1.82179233
82	Deformed sella turcica (HP:0002681)	1.80826075
83	Asymmetric septal hypertrophy (HP:0001670)	1.80725444
84	Seborrheic dermatitis (HP:0001051)	1.78629549
85	Capillary hemangiomas (HP:0005306)	1.78562464
86	Abnormality of the renal collecting system (HP:0004742)	1.77392639
87	Increased cerebral lipofuscin (HP:0011813)	1.77092718
88	Flared iliac wings (HP:0002869)	1.74981688
89	Anteriorly placed anus (HP:0001545)	1.74830433
90	Increased mean platelet volume (HP:0011877)	1.74691159
91	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.74378745
92	Neuronal loss in central nervous system (HP:0002529)	1.74017235
93	Partial duplication of thumb phalanx (HP:0009944)	1.73602863
94	Cerebral palsy (HP:0100021)	1.73023214
95	Hypoparathyroidism (HP:0000829)	1.72410070
96	Abnormality of the epiphyses of the hand (HP:0005924)	1.71825980
97	Down-sloping shoulders (HP:0200021)	1.69380883
98	Abnormal platelet volume (HP:0011876)	1.69178695
99	Gastrointestinal inflammation (HP:0004386)	1.68685060
100	Panhypogammaglobulinemia (HP:0003139)	1.68392203

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK1	7.72697891
2	RIPK4	3.59795687
3	TRIB3	3.54760855
4	SCYL2	3.16623334
5	MUSK	2.93494980
6	CDK12	2.63540569
7	EIF2AK1	2.63106375
8	GRK6	2.63000578
9	NME2	2.26669464
10	CSF1R	1.87855797
11	PKN2	1.76463780
12	MAPKAPK3	1.72723651
13	MAPK15	1.66504027
14	TNK2	1.60351063
15	TAOK3	1.55133884
16	BRD4	1.51853185
17	EIF2AK2	1.49723473
18	PRKD3	1.49464510
19	MAP2K3	1.45687763
20	RPS6KB2	1.34158628
21	HIPK2	1.33687276
22	TEC	1.30712573
23	NME1	1.29846005
24	BTK	1.24180410
25	JAK1	1.10420023
26	SMG1	1.08689670
27	CDK7	1.08608965
28	ZAP70	1.07309278
29	BMPR2	1.05043730
30	ERN1	1.03380806
31	FER	1.03355961
32	ICK	0.98298002
33	RPS6KC1	0.96185557
34	RPS6KL1	0.96185557
35	SYK	0.95231400
36	MTOR	0.93673102
37	PRPF4B	0.91080767
38	TESK2	0.86312000
39	STK38	0.85293420
40	CHUK	0.83963232
41	RPS6KB1	0.82850557
42	RPS6KA6	0.82376327
43	IRAK3	0.81764610
44	MAP2K1	0.81624844
45	RPS6KA2	0.80215381
46	BLK	0.79994529
47	MAP2K2	0.77082828
48	RET	0.72987372
49	PLK1	0.72334918
50	ADRBK1	0.72158850
51	KSR2	0.71560605
52	LRRK2	0.71155101
53	EEF2K	0.69730475
54	JAK2	0.68793623
55	SIK2	0.68677451
56	PDPK1	0.65770188
57	PRKD2	0.60345372
58	PRKD1	0.59961232
59	EPHA3	0.59776339
60	CDC42BPA	0.59275143
61	ITK	0.57814304
62	MAPK11	0.57805252
63	BMX	0.57271977
64	ADRBK2	0.57071628
65	MAP3K3	0.56999139
66	MAPK10	0.56879659
67	PRKAA1	0.55834437
68	WNK1	0.55545561
69	MAP3K1	0.54291470
70	SGK3	0.54125973
71	BMPR1B	0.52388996
72	STK4	0.52332069
73	MAP2K6	0.51102525
74	TAOK1	0.50781201
75	PTK2	0.49923349
76	GRK1	0.49881570
77	DYRK1B	0.47875251
78	FGFR4	0.47640882
79	IKBKB	0.47629550
80	PTK6	0.47147161
81	YES1	0.46863394
82	EPHB1	0.46409730
83	MAP3K6	0.45671066
84	PIM2	0.43644950
85	HCK	0.42619906
86	SIK3	0.41627304
87	RPS6KA1	0.41503241
88	MAPK3	0.41390222
89	MAP3K2	0.39452306
90	ILK	0.38508435
91	MAPK12	0.37465601
92	RAF1	0.35937591
93	IKBKE	0.33556666
94	MAPK4	0.33293212
95	CAMK1D	0.32267364
96	MARK2	0.31840114
97	TYRO3	0.31583824
98	PRKAA2	0.30501402
99	SGK2	0.30355540
100	PDK1	0.30179032

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.70655860
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.64717604
3	Other glycan degradation_Homo sapiens_hsa00511	2.93562453
4	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.92090839
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.25838974
6	mTOR signaling pathway_Homo sapiens_hsa04150	2.11364675
7	Acute myeloid leukemia_Homo sapiens_hsa05221	1.92696938
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.91963107
9	Platelet activation_Homo sapiens_hsa04611	1.77192916
10	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.65892778
11	Sulfur relay system_Homo sapiens_hsa04122	1.53671787
12	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.53365358
13	Sphingolipid metabolism_Homo sapiens_hsa00600	1.50435080
14	VEGF signaling pathway_Homo sapiens_hsa04370	1.50193221
15	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.49940849
16	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.49042119
17	Choline metabolism in cancer_Homo sapiens_hsa05231	1.45373948
18	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.44381760
19	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.35314836
20	Insulin signaling pathway_Homo sapiens_hsa04910	1.30197620
21	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.28626142
22	Endometrial cancer_Homo sapiens_hsa05213	1.25910877
23	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.25887425
24	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.25264863
25	Insulin resistance_Homo sapiens_hsa04931	1.24980870
26	AMPK signaling pathway_Homo sapiens_hsa04152	1.21950797
27	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.21129592
28	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.19946461
29	Thyroid cancer_Homo sapiens_hsa05216	1.18493893
30	Lysosome_Homo sapiens_hsa04142	1.18468679
31	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.16649272
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.16289606
33	Non-small cell lung cancer_Homo sapiens_hsa05223	1.16000937
34	HIF-1 signaling pathway_Homo sapiens_hsa04066	1.13495207
35	Hepatitis C_Homo sapiens_hsa05160	1.11870570
36	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.11799888
37	Notch signaling pathway_Homo sapiens_hsa04330	1.11660750
38	Prolactin signaling pathway_Homo sapiens_hsa04917	1.11505346
39	Lysine degradation_Homo sapiens_hsa00310	1.11125555
40	Endocytosis_Homo sapiens_hsa04144	1.10995024
41	Type II diabetes mellitus_Homo sapiens_hsa04930	1.06917208
42	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.06561078
43	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.04632420
44	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.02425175
45	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.02082682
46	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.99963188
47	Chemokine signaling pathway_Homo sapiens_hsa04062	0.99665008
48	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.94373659
49	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.93911500
50	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.91063340
51	ErbB signaling pathway_Homo sapiens_hsa04012	0.90374085
52	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.89898072
53	Estrogen signaling pathway_Homo sapiens_hsa04915	0.89589652
54	Pancreatic cancer_Homo sapiens_hsa05212	0.86383245
55	Sulfur metabolism_Homo sapiens_hsa00920	0.85522783
56	Renal cell carcinoma_Homo sapiens_hsa05211	0.80721301
57	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.79705755
58	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.77375768
59	Osteoclast differentiation_Homo sapiens_hsa04380	0.77100726
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.76799172
61	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.76743894
62	Prostate cancer_Homo sapiens_hsa05215	0.74736282
63	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.73902363
64	Gap junction_Homo sapiens_hsa04540	0.73633127
65	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.73454196
66	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.72275797
67	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.70796984
68	ABC transporters_Homo sapiens_hsa02010	0.70191021
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68004402
70	Viral carcinogenesis_Homo sapiens_hsa05203	0.67230157
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65703254
72	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.65329922
73	Amoebiasis_Homo sapiens_hsa05146	0.64991264
74	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.63664120
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.62777351
76	Olfactory transduction_Homo sapiens_hsa04740	0.60794590
77	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.57898430
78	GnRH signaling pathway_Homo sapiens_hsa04912	0.54674069
79	Colorectal cancer_Homo sapiens_hsa05210	0.54533847
80	Bladder cancer_Homo sapiens_hsa05219	0.52855062
81	Alcoholism_Homo sapiens_hsa05034	0.52637314
82	Glioma_Homo sapiens_hsa05214	0.51556627
83	Hepatitis B_Homo sapiens_hsa05161	0.49932361
84	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49339211
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.48809597
86	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.48632923
87	Circadian rhythm_Homo sapiens_hsa04710	0.47169940
88	MAPK signaling pathway_Homo sapiens_hsa04010	0.45569395
89	Taste transduction_Homo sapiens_hsa04742	0.44891824
90	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43956030
91	Melanogenesis_Homo sapiens_hsa04916	0.41035999
92	Malaria_Homo sapiens_hsa05144	0.40312782
93	FoxO signaling pathway_Homo sapiens_hsa04068	0.40118774
94	Focal adhesion_Homo sapiens_hsa04510	0.39656778
95	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.39101947
96	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.39054082
97	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38445915
98	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.38426051
99	Proteoglycans in cancer_Homo sapiens_hsa05205	0.37712924
100	MicroRNAs in cancer_Homo sapiens_hsa05206	0.37454688

CYP2T1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »