CYP2U1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indole-containing compound catabolic process (GO:0042436)4.90049599
2indolalkylamine catabolic process (GO:0046218)4.90049599
3tryptophan catabolic process (GO:0006569)4.90049599
4paraxial mesoderm development (GO:0048339)4.82963621
5aromatic amino acid family catabolic process (GO:0009074)4.62147871
6tryptophan metabolic process (GO:0006568)4.59361566
7L-phenylalanine catabolic process (GO:0006559)4.55403523
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.55403523
9cellular biogenic amine catabolic process (GO:0042402)4.34057447
10amine catabolic process (GO:0009310)4.34057447
11negative regulation of hormone biosynthetic process (GO:0032353)4.28780042
12L-phenylalanine metabolic process (GO:0006558)4.21028241
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.21028241
14bile acid biosynthetic process (GO:0006699)3.87375727
15kynurenine metabolic process (GO:0070189)3.83923520
16regulation of type B pancreatic cell apoptotic process (GO:2000674)3.82203942
17indolalkylamine metabolic process (GO:0006586)3.80251500
18negative regulation of hormone metabolic process (GO:0032351)3.74914348
19regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.68746668
20urea metabolic process (GO:0019627)3.62713367
21urea cycle (GO:0000050)3.62713367
22coenzyme catabolic process (GO:0009109)3.59084171
23protein K11-linked deubiquitination (GO:0035871)3.59064233
24NAD biosynthetic process (GO:0009435)3.50807291
25androgen biosynthetic process (GO:0006702)3.48429929
26serine family amino acid catabolic process (GO:0009071)3.48068685
27aromatic amino acid family metabolic process (GO:0009072)3.46282973
28positive regulation of glycolytic process (GO:0045821)3.44398504
29nitrogen cycle metabolic process (GO:0071941)3.41990047
30regulation of cholesterol esterification (GO:0010872)3.34862113
31glucuronate metabolic process (GO:0019585)3.28532855
32uronic acid metabolic process (GO:0006063)3.28532855
33presynaptic membrane assembly (GO:0097105)3.25359891
34regulation of fibrinolysis (GO:0051917)3.19947178
35complement activation, alternative pathway (GO:0006957)3.15108736
36bile acid metabolic process (GO:0008206)3.12431646
37regulation of glucocorticoid metabolic process (GO:0031943)3.12326947
38regulation of protein activation cascade (GO:2000257)3.11879956
39glyoxylate metabolic process (GO:0046487)3.11456796
40aldehyde catabolic process (GO:0046185)3.10429561
41blood coagulation, intrinsic pathway (GO:0007597)3.08691699
42cellular response to vitamin (GO:0071295)3.07112243
43synaptic vesicle docking involved in exocytosis (GO:0016081)3.06340175
44cellular response to vitamin D (GO:0071305)3.06221751
45cellular glucuronidation (GO:0052695)3.03268324
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.01235286
47metanephric mesenchyme development (GO:0072075)2.99411568
48type B pancreatic cell development (GO:0003323)2.97478231
49short-term memory (GO:0007614)2.96994913
50positive regulation of osteoblast proliferation (GO:0033690)2.96624849
51low-density lipoprotein particle remodeling (GO:0034374)2.95105189
52kidney mesenchyme development (GO:0072074)2.95103966
53regulation of complement activation (GO:0030449)2.94651497
54arginine catabolic process (GO:0006527)2.94263374
55alpha-amino acid catabolic process (GO:1901606)2.94111997
56nucleotide transmembrane transport (GO:1901679)2.93676455
57very-low-density lipoprotein particle assembly (GO:0034379)2.92436000
58tyrosine metabolic process (GO:0006570)2.90665683
59activation of protein kinase B activity (GO:0032148)2.89867247
60fatty acid elongation (GO:0030497)2.88668550
61polyol transport (GO:0015791)2.88598254
62arginine metabolic process (GO:0006525)2.88574378
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.87822679
64bone trabecula formation (GO:0060346)2.84121584
65regulation of bile acid biosynthetic process (GO:0070857)2.83349963
66high-density lipoprotein particle remodeling (GO:0034375)2.81455165
67imidazole-containing compound metabolic process (GO:0052803)2.81145561
68negative regulation of execution phase of apoptosis (GO:1900118)2.80152158
69regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.80014540
70positive regulation of protein homodimerization activity (GO:0090073)2.79571083
71cytoplasmic mRNA processing body assembly (GO:0033962)2.79250644
72pyridine nucleotide biosynthetic process (GO:0019363)2.79068458
73nicotinamide nucleotide biosynthetic process (GO:0019359)2.79068458
74COPII vesicle coating (GO:0048208)2.78599617
75amino sugar catabolic process (GO:0046348)2.78561939
76regulation of steroid hormone biosynthetic process (GO:0090030)2.77470027
77bile acid and bile salt transport (GO:0015721)2.75553822
78phospholipid efflux (GO:0033700)2.74286918
79triglyceride homeostasis (GO:0070328)2.73168753
80acylglycerol homeostasis (GO:0055090)2.73168753
81regulation of triglyceride catabolic process (GO:0010896)2.71317598
82cell migration involved in heart development (GO:0060973)2.69443720
83N-acetylneuraminate metabolic process (GO:0006054)2.69014378
84positive regulation of cellular amine metabolic process (GO:0033240)2.68724519
85indole-containing compound metabolic process (GO:0042430)2.68680143
86presynaptic membrane organization (GO:0097090)2.68294625
87receptor recycling (GO:0001881)2.67481953
88cofactor catabolic process (GO:0051187)2.66676096
89negative regulation of lipase activity (GO:0060192)2.66408856
90androgen metabolic process (GO:0008209)2.66281709
91cytolysis (GO:0019835)2.65885068
92dermatan sulfate biosynthetic process (GO:0030208)2.65600208
93collagen fibril organization (GO:0030199)2.65184536
94mesenchymal-epithelial cell signaling (GO:0060638)2.64902863
95protein carboxylation (GO:0018214)2.64351492
96peptidyl-glutamic acid carboxylation (GO:0017187)2.64351492
97regulation of short-term neuronal synaptic plasticity (GO:0048172)2.62142717
98cellular response to hepatocyte growth factor stimulus (GO:0035729)2.61026512
99response to hepatocyte growth factor (GO:0035728)2.61026512
100skin morphogenesis (GO:0043589)2.60798022
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60758486
102chondrocyte proliferation (GO:0035988)2.60537330
103melanin metabolic process (GO:0006582)2.59036239
104facial nerve structural organization (GO:0021612)2.58698997
105protein-lipid complex remodeling (GO:0034368)2.58316861
106macromolecular complex remodeling (GO:0034367)2.58316861
107plasma lipoprotein particle remodeling (GO:0034369)2.58316861
108cellular amino acid catabolic process (GO:0009063)2.58310346
109phenylpropanoid metabolic process (GO:0009698)2.56853079
110righting reflex (GO:0060013)2.56728183
111mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56428323
112response to folic acid (GO:0051593)2.55667072
113cyclic nucleotide catabolic process (GO:0009214)2.54569934
114carboxylic acid catabolic process (GO:0046395)2.53821406
115organic acid catabolic process (GO:0016054)2.53821406
116reverse cholesterol transport (GO:0043691)2.53774103
117benzene-containing compound metabolic process (GO:0042537)2.52400799
118inner ear receptor cell development (GO:0060119)2.51421432
119very long-chain fatty acid metabolic process (GO:0000038)2.50968094
120regulation of timing of cell differentiation (GO:0048505)2.50903069
121daunorubicin metabolic process (GO:0044597)2.50702824
122polyketide metabolic process (GO:0030638)2.50702824
123doxorubicin metabolic process (GO:0044598)2.50702824
124positive regulation of protein autophosphorylation (GO:0031954)2.49993275
125protein activation cascade (GO:0072376)2.49442367
126peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.48510100
127pyrimidine nucleobase catabolic process (GO:0006208)2.48385971
128cholesterol efflux (GO:0033344)2.47917587
129protein heterotrimerization (GO:0070208)2.47323452
130amino-acid betaine metabolic process (GO:0006577)2.47166963
131adenosine metabolic process (GO:0046085)2.45326973
132fatty acid homeostasis (GO:0055089)2.43598906
133respiratory chain complex IV assembly (GO:0008535)2.42470868
134negative regulation of protein activation cascade (GO:2000258)2.42323460
135cell differentiation involved in metanephros development (GO:0072202)2.41672857
136secondary metabolite biosynthetic process (GO:0044550)2.39862091
137mesenchymal cell differentiation involved in kidney development (GO:0072161)2.39327554
138mesenchymal cell differentiation involved in renal system development (GO:2001012)2.39327554
139midgut development (GO:0007494)2.38704661
140dermatan sulfate metabolic process (GO:0030205)2.37677143
141regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.36909989
142extracellular matrix assembly (GO:0085029)2.36885935
143cGMP-mediated signaling (GO:0019934)2.33508297
144positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.32207319
145lactate metabolic process (GO:0006089)2.29234277
146positive regulation of glycogen biosynthetic process (GO:0045725)2.26923989
147phospholipid translocation (GO:0045332)2.24147535
148lipid translocation (GO:0034204)2.24147535
149positive regulation of meiosis (GO:0045836)2.23967820
150serotonin receptor signaling pathway (GO:0007210)2.23771509
151type B pancreatic cell proliferation (GO:0044342)2.23604205
152myelination in peripheral nervous system (GO:0022011)2.23436778
153peripheral nervous system axon ensheathment (GO:0032292)2.23436778
154macroautophagy (GO:0016236)2.23391107
155heparan sulfate proteoglycan metabolic process (GO:0030201)2.23045077
156insulin secretion (GO:0030073)2.22288487
157chondrocyte development (GO:0002063)2.20962019
158lymphangiogenesis (GO:0001946)2.20605199
159glandular epithelial cell development (GO:0002068)2.20155301
160artery development (GO:0060840)2.19879101
161tonic smooth muscle contraction (GO:0014820)2.19400134
162regulation of autophagic vacuole assembly (GO:2000785)2.14426313
163photoreceptor cell differentiation (GO:0046530)2.14271207
164eye photoreceptor cell differentiation (GO:0001754)2.14271207
165endocrine pancreas development (GO:0031018)2.11069497
166establishment of protein localization to Golgi (GO:0072600)2.11063719
167urinary tract smooth muscle contraction (GO:0014848)2.10878844
168negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.10281878
169chemosensory behavior (GO:0007635)2.10156246
170protein localization to cell surface (GO:0034394)2.09388508
171smooth muscle cell differentiation (GO:0051145)2.08402315
172positive regulation of meiotic cell cycle (GO:0051446)2.08135966
173vascular smooth muscle contraction (GO:0014829)2.07907029
174cellular zinc ion homeostasis (GO:0006882)2.07574930
175cardiac myofibril assembly (GO:0055003)2.07528675
176regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.07485335
177myofibril assembly (GO:0030239)2.06707089
178smooth muscle tissue development (GO:0048745)2.04641912
179regulation of osteoblast proliferation (GO:0033688)2.04594567
180regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.04575436
181melanin biosynthetic process (GO:0042438)2.04353131
182fibroblast migration (GO:0010761)2.04309709
183innervation (GO:0060384)2.03958029
184glomerular basement membrane development (GO:0032836)2.02393144
185negative regulation of bone remodeling (GO:0046851)2.01627825
186regulation of hormone biosynthetic process (GO:0046885)2.01416255
187interleukin-6-mediated signaling pathway (GO:0070102)2.01201439
188anterior/posterior axis specification, embryo (GO:0008595)2.00904515
189cyclic-nucleotide-mediated signaling (GO:0019935)1.99284092
190regulation of protein glycosylation (GO:0060049)1.98967532
191sequestering of extracellular ligand from receptor (GO:0035581)1.98382167
192carnitine metabolic process (GO:0009437)1.97291326
193detection of calcium ion (GO:0005513)1.97153045
194regulation of appetite (GO:0032098)1.97076285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77574581
2GBX2_23144817_ChIP-Seq_PC3_Human3.54720665
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.45423802
4EZH2_22144423_ChIP-Seq_EOC_Human2.99857927
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.84890287
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53753776
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52538924
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.40019878
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.38582198
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.30029714
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28960362
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.28005498
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27878108
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.18435866
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13215260
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.10128318
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.02939814
18TAF15_26573619_Chip-Seq_HEK293_Human2.01742876
19EP300_21415370_ChIP-Seq_HL-1_Mouse1.98126497
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.89116114
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86915007
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85675908
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.83954412
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82962139
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80016890
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.78303324
27TP53_18474530_ChIP-ChIP_U2OS_Human1.78149471
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78020264
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.76419988
30* LXR_22158963_ChIP-Seq_LIVER_Mouse1.76096605
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76026745
32FUS_26573619_Chip-Seq_HEK293_Human1.71814042
33EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.69589793
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68685068
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68039773
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67288087
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65421895
38SUZ12_18555785_Chip-Seq_ESCs_Mouse1.64890389
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64342996
40AR_25329375_ChIP-Seq_VCAP_Human1.64323894
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.63389525
42EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.63368189
43P53_22387025_ChIP-Seq_ESCs_Mouse1.62919929
44RUNX1_27457419_Chip-Seq_LIVER_Mouse1.60728644
45BRD4_25478319_ChIP-Seq_HGPS_Human1.59902450
46STAT3_18555785_Chip-Seq_ESCs_Mouse1.59286492
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.58613708
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.58365842
49E2F1_18555785_Chip-Seq_ESCs_Mouse1.58319452
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.57351481
51P300_19829295_ChIP-Seq_ESCs_Human1.56578553
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55921155
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55516399
54P300_18555785_Chip-Seq_ESCs_Mouse1.54968023
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54846090
56NMYC_18555785_Chip-Seq_ESCs_Mouse1.54685868
57* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54597691
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52984375
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51792586
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50987274
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49857793
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49015765
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49015765
64VDR_22108803_ChIP-Seq_LS180_Human1.47649857
65STAT3_23295773_ChIP-Seq_U87_Human1.47015220
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45063627
67CJUN_26792858_Chip-Seq_BT549_Human1.43639852
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41573949
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41264243
70SOX2_18555785_Chip-Seq_ESCs_Mouse1.40492998
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40214376
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.39655110
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.39593710
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.38774395
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38547801
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.38523773
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38489789
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38489789
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.38168923
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37302192
81OCT4_18555785_Chip-Seq_ESCs_Mouse1.37281819
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36794168
83AR_21572438_ChIP-Seq_LNCaP_Human1.36785293
84IRF1_19129219_ChIP-ChIP_H3396_Human1.36207709
85PU1_27457419_Chip-Seq_LIVER_Mouse1.35890094
86ZFX_18555785_Chip-Seq_ESCs_Mouse1.34735704
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32950405
88TP53_16413492_ChIP-PET_HCT116_Human1.32936409
89HTT_18923047_ChIP-ChIP_STHdh_Human1.32512400
90ESRRB_18555785_Chip-Seq_ESCs_Mouse1.32208952
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31154289
92SMAD1_18555785_Chip-Seq_ESCs_Mouse1.29687362
93EWS_26573619_Chip-Seq_HEK293_Human1.29597671
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29525505
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.28389166
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27883734
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27876771
98TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27512245
99* KLF4_18555785_Chip-Seq_ESCs_Mouse1.27284995
100BCAT_22108803_ChIP-Seq_LS180_Human1.27203702
101RNF2_27304074_Chip-Seq_NSC_Mouse1.25931432
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25705171
103TCF4_23295773_ChIP-Seq_U87_Human1.25515863
104CTCF_18555785_Chip-Seq_ESCs_Mouse1.25197650
105ER_23166858_ChIP-Seq_MCF-7_Human1.25150239
106TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25044471
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24939941
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24853237
109OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23906534
110SMAD4_21799915_ChIP-Seq_A2780_Human1.23734816
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22398636
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22149513
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21146110
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.21139227
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20530605
116IGF1R_20145208_ChIP-Seq_DFB_Human1.19235607
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18735649
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17226731
119* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17053578
120WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14711594
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.14009329
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13647414
123SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13308302
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12991376
125* CDX2_22108803_ChIP-Seq_LS180_Human1.12926374
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12211240
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11044282
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10286045
129MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10239350
130RNF2_27304074_Chip-Seq_ESCs_Mouse1.10082625
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09459969
132KDM2B_26808549_Chip-Seq_REH_Human1.09215678
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06700980
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06003000
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05631096
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04456333
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04271351
138TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04200711
139RUNX2_22187159_ChIP-Seq_PCA_Human1.03116263
140ARNT_22903824_ChIP-Seq_MCF-7_Human1.03080190
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02631207
142ESR1_20079471_ChIP-ChIP_T-47D_Human1.01717561
143CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01188537
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01036046
145CBP_20019798_ChIP-Seq_JUKART_Human1.00366974
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00366974
147KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00130741
148SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99942543
149LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99802279
150AR_19668381_ChIP-Seq_PC3_Human0.98007182
151CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97888957
152* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97555688
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97459613
154TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97216448
155FLI1_21867929_ChIP-Seq_TH2_Mouse0.97140103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.49599060
2MP0002139_abnormal_hepatobiliary_system4.49454864
3MP0003136_yellow_coat_color4.15294832
4MP0005360_urolithiasis3.97340517
5MP0005085_abnormal_gallbladder_physiolo3.94564866
6MP0003283_abnormal_digestive_organ3.72000963
7MP0000566_synostosis3.48165778
8MP0004381_abnormal_hair_follicle3.46009191
9MP0005503_abnormal_tendon_morphology3.40311534
10MP0006292_abnormal_olfactory_placode3.23273694
11MP0005365_abnormal_bile_salt3.18977623
12MP0001188_hyperpigmentation3.12520242
13MP0009780_abnormal_chondrocyte_physiolo2.84792507
14MP0005409_darkened_coat_color2.80593321
15MP0004272_abnormal_basement_membrane2.74463857
16MP0009697_abnormal_copulation2.59205585
17MP0005257_abnormal_intraocular_pressure2.47388924
18MP0003252_abnormal_bile_duct2.39618881
19MP0008875_abnormal_xenobiotic_pharmacok2.36067031
20MP0003011_delayed_dark_adaptation2.35590933
21MP0002876_abnormal_thyroid_physiology2.32730982
22MP0009379_abnormal_foot_pigmentation2.30707871
23MP0003195_calcinosis2.23753203
24MP0005275_abnormal_skin_tensile2.20594285
25MP0000462_abnormal_digestive_system2.16039952
26MP0001986_abnormal_taste_sensitivity2.06116278
27MP0001299_abnormal_eye_distance/2.05037574
28MP0003279_aneurysm2.03624846
29MP0000569_abnormal_digit_pigmentation1.95989384
30MP0003941_abnormal_skin_development1.88916261
31MP0003705_abnormal_hypodermis_morpholog1.88683916
32MP0005084_abnormal_gallbladder_morpholo1.84982363
33MP0000372_irregular_coat_pigmentation1.84030753
34MP0008260_abnormal_autophagy1.82254024
35MP0003183_abnormal_peptide_metabolism1.81986527
36MP0005171_absent_coat_pigmentation1.77143435
37MP0001958_emphysema1.77019861
38MP0000015_abnormal_ear_pigmentation1.68581261
39MP0006054_spinal_hemorrhage1.68239133
40MP0003806_abnormal_nucleotide_metabolis1.67596756
41MP0005646_abnormal_pituitary_gland1.64936290
42MP0004019_abnormal_vitamin_homeostasis1.64032902
43MP0003868_abnormal_feces_composition1.63887717
44MP0002295_abnormal_pulmonary_circulatio1.63125626
45MP0010234_abnormal_vibrissa_follicle1.61843182
46MP0005332_abnormal_amino_acid1.61662962
47MP0010329_abnormal_lipoprotein_level1.56166450
48MP0005075_abnormal_melanosome_morpholog1.55829148
49MP0002108_abnormal_muscle_morphology1.53423284
50MP0006276_abnormal_autonomic_nervous1.51490720
51MP0010352_gastrointestinal_tract_polyps1.50258114
52MP0005623_abnormal_meninges_morphology1.49782030
53MP0005408_hypopigmentation1.43460330
54MP0004142_abnormal_muscle_tone1.41786013
55MP0001764_abnormal_homeostasis1.36434046
56MP0002090_abnormal_vision1.35928734
57MP0010368_abnormal_lymphatic_system1.35321339
58MP0002638_abnormal_pupillary_reflex1.35034299
59MP0005551_abnormal_eye_electrophysiolog1.33932082
60MP0003880_abnormal_central_pattern1.29788165
61MP0002138_abnormal_hepatobiliary_system1.27788523
62MP0000534_abnormal_ureter_morphology1.27778492
63MP0001270_distended_abdomen1.26787425
64MP0003724_increased_susceptibility_to1.24784462
65MP0009250_abnormal_appendicular_skeleto1.19792922
66MP0003385_abnormal_body_wall1.17809472
67MP0001984_abnormal_olfaction1.16900866
68MP0002909_abnormal_adrenal_gland1.14919926
69MP0000428_abnormal_craniofacial_morphol1.14257409
70MP0005645_abnormal_hypothalamus_physiol1.14041848
71MP0005508_abnormal_skeleton_morphology1.13394991
72MP0009384_cardiac_valve_regurgitation1.12899265
73MP0001879_abnormal_lymphatic_vessel1.12444573
74MP0005647_abnormal_sex_gland1.12348365
75MP0001666_abnormal_nutrient_absorption1.11694015
76MP0001486_abnormal_startle_reflex1.08681496
77MP0004134_abnormal_chest_morphology1.07897656
78MP0000751_myopathy1.07634642
79MP0004859_abnormal_synaptic_plasticity1.06435612
80MP0002249_abnormal_larynx_morphology1.06331325
81MP0005670_abnormal_white_adipose1.06073804
82MP0005379_endocrine/exocrine_gland_phen1.04492216
83MP0005187_abnormal_penis_morphology1.03439976
84MP0002896_abnormal_bone_mineralization1.03276269
85MP0000026_abnormal_inner_ear1.02958341
86MP0003942_abnormal_urinary_system1.02727986
87MP0005451_abnormal_body_composition1.02562488
88MP0002132_abnormal_respiratory_system1.02160344
89MP0000749_muscle_degeneration1.01947844
90MP0004742_abnormal_vestibular_system1.00959010
91MP0004270_analgesia1.00599008
92MP0001944_abnormal_pancreas_morphology0.98692517
93MP0002254_reproductive_system_inflammat0.98540050
94MP0002118_abnormal_lipid_homeostasis0.97194919
95MP0009046_muscle_twitch0.96793074
96MP0009764_decreased_sensitivity_to0.96356387
97MP0003718_maternal_effect0.95759469
98MP0002102_abnormal_ear_morphology0.95736809
99MP0000013_abnormal_adipose_tissue0.95728071
100MP0000371_diluted_coat_color0.94664138
101MP0010030_abnormal_orbit_morphology0.94662220
102MP0002277_abnormal_respiratory_mucosa0.94433363
103MP0002735_abnormal_chemical_nociception0.91783516
104MP0000432_abnormal_head_morphology0.90988510
105MP0000579_abnormal_nail_morphology0.90415454
106MP0003091_abnormal_cell_migration0.90039594
107MP0008004_abnormal_stomach_pH0.89293431
108MP0002269_muscular_atrophy0.88645399
109MP0005174_abnormal_tail_pigmentation0.87914922
110MP0000613_abnormal_salivary_gland0.86794902
111MP0004036_abnormal_muscle_relaxation0.86524443
112MP0000778_abnormal_nervous_system0.84706090
113MP0003950_abnormal_plasma_membrane0.83809418
114MP0002938_white_spotting0.83464771
115MP0000538_abnormal_urinary_bladder0.81985713
116MP0005083_abnormal_biliary_tract0.81768409
117MP0001968_abnormal_touch/_nociception0.81407408
118MP0001502_abnormal_circadian_rhythm0.81275085
119MP0002009_preneoplasia0.80936655
120MP0003755_abnormal_palate_morphology0.79135531
121MP0005535_abnormal_body_temperature0.79096684
122MP0004885_abnormal_endolymph0.78581163
123MP0000767_abnormal_smooth_muscle0.78577944
124MP0002837_dystrophic_cardiac_calcinosis0.77616171
125MP0000759_abnormal_skeletal_muscle0.77553892
126MP0003632_abnormal_nervous_system0.77376240
127MP0001905_abnormal_dopamine_level0.77368675
128MP0001542_abnormal_bone_strength0.76812052
129MP0002067_abnormal_sensory_capabilities0.76673708
130MP0001756_abnormal_urination0.76414377
131MP0003634_abnormal_glial_cell0.76097625
132MP0003633_abnormal_nervous_system0.76064622
133MP0002928_abnormal_bile_duct0.75771077
134MP0001324_abnormal_eye_pigmentation0.75165809
135MP0002168_other_aberrant_phenotype0.75075235
136MP0003646_muscle_fatigue0.74811964
137MP0003935_abnormal_craniofacial_develop0.73904367
138MP0001963_abnormal_hearing_physiology0.73814029
139MP0002272_abnormal_nervous_system0.73206316
140MP0001919_abnormal_reproductive_system0.72762802
141MP0002734_abnormal_mechanical_nocicepti0.72715705
142MP0000163_abnormal_cartilage_morphology0.72708523
143MP0002075_abnormal_coat/hair_pigmentati0.72375674
144MP0002557_abnormal_social/conspecific_i0.71654890
145MP0003937_abnormal_limbs/digits/tail_de0.71103866
146MP0000747_muscle_weakness0.71059643
147MP0003045_fibrosis0.70551111
148MP0003938_abnormal_ear_development0.69010454
149MP0005197_abnormal_uvea_morphology0.68924364
150MP0002751_abnormal_autonomic_nervous0.68677518
151MP0002233_abnormal_nose_morphology0.68635870
152MP0004782_abnormal_surfactant_physiolog0.68303153
153MP0002160_abnormal_reproductive_system0.66877599
154MP0000762_abnormal_tongue_morphology0.66730133
155MP0008789_abnormal_olfactory_epithelium0.66112495
156MP0002095_abnormal_skin_pigmentation0.65809637
157MP0002064_seizures0.65192071
158MP0002060_abnormal_skin_morphology0.64713308
159MP0002115_abnormal_skeleton_extremities0.64504346
160MP0003635_abnormal_synaptic_transmissio0.64361059
161MP0002822_catalepsy0.63314381
162MP0003186_abnormal_redox_activity0.63118031
163MP0009840_abnormal_foam_cell0.62558073
164MP0000631_abnormal_neuroendocrine_gland0.62164016
165MP0005595_abnormal_vascular_smooth0.62145858
166MP0001664_abnormal_digestion0.62041878
167MP0002971_abnormal_brown_adipose0.61517558
168MP0000609_abnormal_liver_physiology0.60833706
169MP0010386_abnormal_urinary_bladder0.60775363
170MP0005253_abnormal_eye_physiology0.60645079
171MP0002177_abnormal_outer_ear0.59961573
172MP0002229_neurodegeneration0.58860583
173MP0002752_abnormal_somatic_nervous0.58786469
174MP0005248_abnormal_Harderian_gland0.57385719
175MP0001186_pigmentation_phenotype0.57016788
176MP0009745_abnormal_behavioral_response0.55576934
177MP0009765_abnormal_xenobiotic_induced0.55309788
178MP0002163_abnormal_gland_morphology0.54753907
179MP0005584_abnormal_enzyme/coenzyme_acti0.53499525

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.69250435
2Prolonged partial thromboplastin time (HP:0003645)5.16555227
3Broad metatarsal (HP:0001783)4.84194102
4Protrusio acetabuli (HP:0003179)4.18938814
5Intrahepatic cholestasis (HP:0001406)4.09960212
6Joint hemorrhage (HP:0005261)4.01753404
7Symptomatic seizures (HP:0011145)3.85620467
8Premature rupture of membranes (HP:0001788)3.83056900
9Conjugated hyperbilirubinemia (HP:0002908)3.80722698
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.63358044
11Hyperglycinemia (HP:0002154)3.61311226
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.58082728
13Aortic aneurysm (HP:0004942)3.54492023
14Abnormality of dentin (HP:0010299)3.41505656
15Renal cortical cysts (HP:0000803)3.33476745
16Vascular tortuosity (HP:0004948)3.33041830
17Large for gestational age (HP:0001520)3.22110880
18Hyperglycinuria (HP:0003108)3.16614537
19Enlarged penis (HP:0000040)3.12642946
20Hypothermia (HP:0002045)3.00101465
21Abnormality of endocrine pancreas physiology (HP:0012093)2.97285762
22Abnormality of the pancreatic islet cells (HP:0006476)2.97285762
23Complement deficiency (HP:0004431)2.96332183
24Shallow orbits (HP:0000586)2.94392606
25Reduced antithrombin III activity (HP:0001976)2.93464480
26Abnormality of pyrimidine metabolism (HP:0004353)2.92283953
27Abnormality of secondary sexual hair (HP:0009888)2.85599028
28Abnormality of the axillary hair (HP:0100134)2.85599028
29Bile duct proliferation (HP:0001408)2.84407796
30Abnormal biliary tract physiology (HP:0012439)2.84407796
31Renal Fanconi syndrome (HP:0001994)2.82677925
323-Methylglutaconic aciduria (HP:0003535)2.80713075
33Type I transferrin isoform profile (HP:0003642)2.77757473
34Ankle contracture (HP:0006466)2.75152646
35Arterial tortuosity (HP:0005116)2.74241345
36Optic disc pallor (HP:0000543)2.73505526
37Ketoacidosis (HP:0001993)2.72887428
38Wormian bones (HP:0002645)2.72810148
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.70923567
40Aortic dissection (HP:0002647)2.70469161
41Cerebral edema (HP:0002181)2.61745368
42Abnormality of serine family amino acid metabolism (HP:0010894)2.59027218
43Abnormality of glycine metabolism (HP:0010895)2.59027218
44Hypoplasia of the fovea (HP:0007750)2.56953103
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.56953103
46Epidermoid cyst (HP:0200040)2.56653967
47Insulin-resistant diabetes mellitus (HP:0000831)2.54871825
48Abnormality of serum amino acid levels (HP:0003112)2.52904294
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52619822
50Overgrowth (HP:0001548)2.49892606
51Hypoventilation (HP:0002791)2.49670274
52Hyperglycemia (HP:0003074)2.47599822
53Hepatoblastoma (HP:0002884)2.46462749
54White forelock (HP:0002211)2.45124568
55True hermaphroditism (HP:0010459)2.42586884
56Hepatic necrosis (HP:0002605)2.41561674
57Abnormality of renal resorption (HP:0011038)2.39891693
58Neonatal short-limb short stature (HP:0008921)2.39247296
59Acute necrotizing encephalopathy (HP:0006965)2.39233094
60Hydroxyprolinuria (HP:0003080)2.39119946
61Abnormality of proline metabolism (HP:0010907)2.39119946
62Dry hair (HP:0011359)2.37880627
63Mitochondrial inheritance (HP:0001427)2.37262134
64Coronal craniosynostosis (HP:0004440)2.35267823
65Deep venous thrombosis (HP:0002625)2.35065400
66Febrile seizures (HP:0002373)2.34937512
67Increased circulating renin level (HP:0000848)2.33974677
68Mitral stenosis (HP:0001718)2.32562969
69Microvesicular hepatic steatosis (HP:0001414)2.32531625
70Abnormality of methionine metabolism (HP:0010901)2.32518261
71Acute encephalopathy (HP:0006846)2.31883092
72Xanthomatosis (HP:0000991)2.31799116
73Patchy hypopigmentation of hair (HP:0011365)2.31282610
74Hepatocellular necrosis (HP:0001404)2.29991353
75Soft skin (HP:0000977)2.29054951
76Fat malabsorption (HP:0002630)2.28808993
77Hyperlipoproteinemia (HP:0010980)2.27905340
78Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26410418
79Hypophosphatemic rickets (HP:0004912)2.24541566
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24519100
81Epileptiform EEG discharges (HP:0011182)2.23999748
82Fair hair (HP:0002286)2.23689129
83Hypobetalipoproteinemia (HP:0003563)2.22930692
84Abnormal sex determination (HP:0012244)2.22639011
85Sex reversal (HP:0012245)2.22639011
86Decreased central vision (HP:0007663)2.22550642
87Delayed gross motor development (HP:0002194)2.19194950
88Lethargy (HP:0001254)2.17997573
89Increased hepatocellular lipid droplets (HP:0006565)2.17814658
90EEG with generalized epileptiform discharges (HP:0011198)2.17749596
91Attenuation of retinal blood vessels (HP:0007843)2.15684941
92Lipid accumulation in hepatocytes (HP:0006561)2.14098173
93Abnormality of urine glucose concentration (HP:0011016)2.11930354
94Glycosuria (HP:0003076)2.11930354
95Abnormal mitochondria in muscle tissue (HP:0008316)2.10425391
96Vertebral compression fractures (HP:0002953)2.09703731
97Abnormality of the calf musculature (HP:0001430)2.09636636
98Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07732120
99Type 1 muscle fiber predominance (HP:0003803)2.07376062
100Abnormality of the fovea (HP:0000493)2.06798970
101Spinal rigidity (HP:0003306)2.06541945
102Renal tubular dysfunction (HP:0000124)2.06172470
103Abnormality of complement system (HP:0005339)2.06153666
104Enlarged kidneys (HP:0000105)2.05909453
105Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04955583
106Hyperphosphatemia (HP:0002905)2.04181981
107Genu recurvatum (HP:0002816)2.04115419
108Bladder diverticulum (HP:0000015)2.03634315
109Abnormal pancreas size (HP:0012094)2.03226806
110Action tremor (HP:0002345)2.02599134
111Thyroid-stimulating hormone excess (HP:0002925)2.02583671
112Chronic hepatic failure (HP:0100626)2.00798277
113Aplasia/Hypoplasia of the macula (HP:0008059)1.97671382
114Increased CSF lactate (HP:0002490)1.97132934
115Tubulointerstitial nephritis (HP:0001970)1.97083263
116Hypsarrhythmia (HP:0002521)1.96946718
117Pancreatic islet-cell hyperplasia (HP:0004510)1.96927610
118Alveolar cell carcinoma (HP:0006519)1.96074385
119Hyperextensible skin (HP:0000974)1.95267127
120Cardiovascular calcification (HP:0011915)1.94283142
121Hypoglycemic coma (HP:0001325)1.94217871
122Increased variability in muscle fiber diameter (HP:0003557)1.93492300
123Tetraparesis (HP:0002273)1.93217875
124Progressive external ophthalmoplegia (HP:0000590)1.93076416
125Hypoglycemic seizures (HP:0002173)1.92416788
126Abnormality of the metopic suture (HP:0005556)1.91559840
127Progressive macrocephaly (HP:0004481)1.90819173
128Bilateral sensorineural hearing impairment (HP:0008619)1.90803779
129Optic nerve hypoplasia (HP:0000609)1.90397824
130Prominent metopic ridge (HP:0005487)1.90090754
131Male pseudohermaphroditism (HP:0000037)1.89889574
132Dyschromatopsia (HP:0007641)1.89503191
133Limb-girdle muscle weakness (HP:0003325)1.89333613
134Osteomalacia (HP:0002749)1.88249648
135Abnormality of the intrinsic pathway (HP:0010989)1.87954153
136Vascular calcification (HP:0004934)1.87862627
137Abnormality of fatty-acid metabolism (HP:0004359)1.87581773
138Abnormality of the ischium (HP:0003174)1.87528205
139Generalized hypopigmentation of hair (HP:0011358)1.86825608
140Prolonged neonatal jaundice (HP:0006579)1.86693190
141Congenital stationary night blindness (HP:0007642)1.86116063
142Anomalous pulmonary venous return (HP:0010772)1.85972547
143Hypoplastic ischia (HP:0003175)1.85840201
144Generalized aminoaciduria (HP:0002909)1.85537300
145Bowel diverticulosis (HP:0005222)1.85106153
146Medial flaring of the eyebrow (HP:0010747)1.84456880
147Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83281128
148Knee flexion contracture (HP:0006380)1.83128017
149Congenital hepatic fibrosis (HP:0002612)1.80309523
150Blue irides (HP:0000635)1.79835936
151Aplasia/Hypoplasia of the tibia (HP:0005772)1.79744605
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79407489
153Septo-optic dysplasia (HP:0100842)1.79403328
154Congenital sensorineural hearing impairment (HP:0008527)1.79399791
155Hyperammonemia (HP:0001987)1.79181448
156Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78977633
157Dicarboxylic aciduria (HP:0003215)1.78977633
158Abnormality of the renal cortex (HP:0011035)1.78857588
159Cerebral palsy (HP:0100021)1.78105397
160Atrophic scars (HP:0001075)1.77247882
161Aortic regurgitation (HP:0001659)1.76005277
162Wide anterior fontanel (HP:0000260)1.75425122
163Hypoplasia of the iris (HP:0007676)1.74869994
164Thoracolumbar scoliosis (HP:0002944)1.71730914
165Biconcave vertebral bodies (HP:0004586)1.70564577
166Abnormality of the musculature of the pelvis (HP:0001469)1.70064749
167Abnormality of the hip-girdle musculature (HP:0001445)1.70064749
168Broad ribs (HP:0000885)1.69916501
169Heterochromia iridis (HP:0001100)1.69436625
170Calf muscle hypertrophy (HP:0008981)1.68921089
171Aortic valve stenosis (HP:0001650)1.66076765
172Partial duplication of the phalanx of hand (HP:0009999)1.64589646
173Delayed closure of the anterior fontanelle (HP:0001476)1.64301479
174Congenital glaucoma (HP:0001087)1.63675274
175Hemiparesis (HP:0001269)1.62673467
176Follicular hyperkeratosis (HP:0007502)1.62166134
177Proximal amyotrophy (HP:0007126)1.62041710
178Osteolytic defects of the phalanges of the hand (HP:0009771)1.61384951
179Osteolytic defects of the hand bones (HP:0009699)1.61384951
180Hypomagnesemia (HP:0002917)1.61258441
181Late onset (HP:0003584)1.58682453
182Turricephaly (HP:0000262)1.58475535
183Dilatation of the ascending aorta (HP:0005111)1.56675212
184Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.55411884
185Macroorchidism (HP:0000053)1.55331243
186Long toe (HP:0010511)1.54703283
187Type I diabetes mellitus (HP:0100651)1.54009138
188Frequent falls (HP:0002359)1.52989671
189Partial duplication of thumb phalanx (HP:0009944)1.52923702
190Subaortic stenosis (HP:0001682)1.51858952
191Abnormality of the left ventricular outflow tract (HP:0011103)1.51858952
192Short nail (HP:0001799)1.51730832
193Round face (HP:0000311)1.50532979
194Insulin resistance (HP:0000855)1.49991196
195Redundant skin (HP:0001582)1.49338155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.59973360
2FRK5.02890860
3IRAK33.12684889
4FGFR22.97974057
5INSRR2.86451505
6MKNK22.76850606
7PRPF4B2.76570888
8TNIK2.70662525
9PNCK2.70242616
10PASK2.65788021
11LATS12.36054264
12ZAK2.31808633
13NTRK32.26091560
14PDGFRA2.15548011
15TLK12.07499552
16AKT32.05005320
17IRAK41.97737357
18MUSK1.97247722
19CAMK1G1.97128287
20MAP2K71.91918704
21MAPK131.91000812
22DDR21.82438979
23NME21.81486006
24STK161.74354360
25GRK11.71590058
26IRAK21.64815430
27IRAK11.61444276
28MAP3K21.60515126
29TXK1.53861562
30WNK31.48923714
31TRPM71.47841571
32SGK21.46754720
33BMPR21.46503564
34PINK11.40272590
35MKNK11.37616109
36LATS21.36723618
37SRPK11.35628553
38YES11.34781280
39NEK61.34169503
40MAP3K141.31520346
41PRKD31.29823957
42CDK31.26471855
43EIF2AK21.25883186
44BMPR1B1.24343487
45NLK1.23767933
46PAK31.22463226
47BCKDK1.22088042
48ADRBK21.21479200
49CSNK1A1L1.19264517
50ERBB41.17589989
51SGK4941.14201021
52SGK2231.14201021
53STK38L1.13217257
54MAPK151.12925588
55TNK21.11457429
56CSNK1G21.10284707
57PAK21.10089641
58PKN11.09154712
59CAMK1D1.07902265
60PDGFRB1.07494054
61LIMK11.05632139
62PRKD21.05623945
63MAPK111.04052681
64PTK21.00438630
65TAOK30.96931233
66TEC0.96008047
67CSNK1G30.95991146
68GRK70.95684026
69STK30.94822362
70FGFR30.93624349
71TTN0.91787595
72MAP3K120.91573409
73EIF2AK30.91127019
74FER0.90854965
75PBK0.90844829
76STK390.89921502
77NTRK10.88142606
78ROCK20.86735279
79IKBKE0.82256577
80TIE10.80738356
81MOS0.79580277
82EPHA30.79334182
83CDK120.78601196
84PIK3CG0.78554832
85PIK3CA0.78224972
86MAPK120.77288304
87NEK90.76337577
88PRKCE0.75872771
89SGK30.74061277
90CLK10.73914276
91MYLK0.73161890
92PRKCH0.72427656
93MET0.71246223
94PRKAA20.70625948
95PLK20.69856155
96SIK30.69392244
97NUAK10.69225839
98ADRBK10.68802065
99MARK10.68385838
100MAP3K70.66222326
101DMPK0.65819080
102CAMK2G0.64764757
103MAP3K40.64712601
104IKBKB0.64410267
105ROCK10.64288862
106EPHB20.61343149
107TGFBR10.61162541
108PHKG10.60593252
109PHKG20.60593252
110MAP3K10.59328487
111GSK3A0.59080847
112OBSCN0.58684356
113WNK10.58651433
114NTRK20.58161473
115CAMK2B0.56163478
116PRKG20.56046489
117BRD40.54065062
118CAMK2D0.53298398
119CAMK2A0.51893895
120PRKACA0.51590188
121DYRK30.51193320
122CDK80.50736782
123DYRK20.49943764
124MAPK70.49811401
125MTOR0.49604710
126FES0.49243738
127MAPK40.49120458
128CDK50.48088913
129OXSR10.48069363
130RPS6KA40.47942659
131ACVR1B0.47853125
132RIPK10.47738236
133KSR20.46959367
134BLK0.46636806
135PRKCZ0.45966460
136CAMK10.45779248
137DYRK1A0.45558040
138UHMK10.45176485
139TGFBR20.44394427
140BRSK20.43717828
141PLK40.43663570
142MAP2K10.43533637
143MAP2K60.42982370
144HIPK20.42424326
145EPHA40.41063452
146STK380.40151706
147STK240.39564435
148CSNK1G10.39415731
149PRKG10.39271201
150WNK40.37612835
151SIK10.35943657
152GRK50.35467895
153PRKCQ0.34575097
154FGFR40.34156987
155RPS6KB10.33470382
156BRAF0.32988291
157MAPKAPK50.32716153
158VRK10.32225749
159CAMK40.28513634
160PRKCG0.27927705
161PRKCA0.26840968

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.75365916
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.64857292
3Fatty acid elongation_Homo sapiens_hsa000622.54848538
4Steroid hormone biosynthesis_Homo sapiens_hsa001402.53849096
5Tryptophan metabolism_Homo sapiens_hsa003802.33556097
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33278397
7Peroxisome_Homo sapiens_hsa041462.32844559
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.28569501
9Complement and coagulation cascades_Homo sapiens_hsa046102.26265861
10Retinol metabolism_Homo sapiens_hsa008302.22416907
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20184105
12Insulin secretion_Homo sapiens_hsa049112.16674683
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.11582336
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06364653
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.01476419
16Histidine metabolism_Homo sapiens_hsa003402.00330442
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98939964
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.97849231
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93140799
20Fatty acid degradation_Homo sapiens_hsa000711.87981762
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86658426
22Chemical carcinogenesis_Homo sapiens_hsa052041.86159213
23beta-Alanine metabolism_Homo sapiens_hsa004101.83456824
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.82165166
25Sulfur metabolism_Homo sapiens_hsa009201.72626288
26Arginine biosynthesis_Homo sapiens_hsa002201.72585257
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72115411
28Vitamin B6 metabolism_Homo sapiens_hsa007501.65445663
29Propanoate metabolism_Homo sapiens_hsa006401.61244620
30Steroid biosynthesis_Homo sapiens_hsa001001.60361316
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56983526
32Phototransduction_Homo sapiens_hsa047441.56324953
33Butanoate metabolism_Homo sapiens_hsa006501.54870526
34Renin secretion_Homo sapiens_hsa049241.53307308
35Oxidative phosphorylation_Homo sapiens_hsa001901.52982466
36ECM-receptor interaction_Homo sapiens_hsa045121.50784098
37Tyrosine metabolism_Homo sapiens_hsa003501.49830898
38Vitamin digestion and absorption_Homo sapiens_hsa049771.44548246
39Type II diabetes mellitus_Homo sapiens_hsa049301.43836673
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.42927780
41ABC transporters_Homo sapiens_hsa020101.42516391
42Melanogenesis_Homo sapiens_hsa049161.41555254
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41013267
44PPAR signaling pathway_Homo sapiens_hsa033201.39304281
45Protein digestion and absorption_Homo sapiens_hsa049741.36818223
46Fatty acid metabolism_Homo sapiens_hsa012121.33285277
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31039086
48Starch and sucrose metabolism_Homo sapiens_hsa005001.29750106
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.28077510
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27344665
51Dorso-ventral axis formation_Homo sapiens_hsa043201.27244526
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26695754
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.25741503
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24068582
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.22353699
56Phenylalanine metabolism_Homo sapiens_hsa003601.21643916
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20602451
58Focal adhesion_Homo sapiens_hsa045101.20456023
59Hedgehog signaling pathway_Homo sapiens_hsa043401.18880599
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18432435
61Staphylococcus aureus infection_Homo sapiens_hsa051501.16281987
62Circadian entrainment_Homo sapiens_hsa047131.15561163
63Basal cell carcinoma_Homo sapiens_hsa052171.14993220
64Adherens junction_Homo sapiens_hsa045201.11616777
65Amphetamine addiction_Homo sapiens_hsa050311.11397345
66TGF-beta signaling pathway_Homo sapiens_hsa043501.08189056
67Hippo signaling pathway_Homo sapiens_hsa043901.05123678
68Dilated cardiomyopathy_Homo sapiens_hsa054141.04239065
69Dopaminergic synapse_Homo sapiens_hsa047281.03870413
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03732534
71Protein export_Homo sapiens_hsa030601.03595353
72Linoleic acid metabolism_Homo sapiens_hsa005911.02263833
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02235310
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00838095
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00064307
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99079298
77AMPK signaling pathway_Homo sapiens_hsa041520.98802453
78Melanoma_Homo sapiens_hsa052180.98057325
79Salivary secretion_Homo sapiens_hsa049700.97142030
80Prostate cancer_Homo sapiens_hsa052150.96580414
81Parkinsons disease_Homo sapiens_hsa050120.95971958
82Ether lipid metabolism_Homo sapiens_hsa005650.95624447
83Folate biosynthesis_Homo sapiens_hsa007900.95188887
84N-Glycan biosynthesis_Homo sapiens_hsa005100.92776915
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92534795
86Arginine and proline metabolism_Homo sapiens_hsa003300.92493067
87* Arachidonic acid metabolism_Homo sapiens_hsa005900.92336911
88mTOR signaling pathway_Homo sapiens_hsa041500.91690393
89Sulfur relay system_Homo sapiens_hsa041220.91223459
90Gap junction_Homo sapiens_hsa045400.89237051
91Sphingolipid metabolism_Homo sapiens_hsa006000.88092367
92Glucagon signaling pathway_Homo sapiens_hsa049220.87025182
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86249354
94* Metabolic pathways_Homo sapiens_hsa011000.85365774
95cAMP signaling pathway_Homo sapiens_hsa040240.83722267
96Oxytocin signaling pathway_Homo sapiens_hsa049210.83668080
97Wnt signaling pathway_Homo sapiens_hsa043100.83099170
98Calcium signaling pathway_Homo sapiens_hsa040200.82951214
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82536262
100Cholinergic synapse_Homo sapiens_hsa047250.81066989
101Gastric acid secretion_Homo sapiens_hsa049710.80405749
102Cocaine addiction_Homo sapiens_hsa050300.79854386
103Thyroid hormone synthesis_Homo sapiens_hsa049180.79217040
104Alzheimers disease_Homo sapiens_hsa050100.77313928
105Fat digestion and absorption_Homo sapiens_hsa049750.76625801
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76615890
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76532565
108Pancreatic secretion_Homo sapiens_hsa049720.74651099
109Fanconi anemia pathway_Homo sapiens_hsa034600.72524706
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72120900
111Bile secretion_Homo sapiens_hsa049760.71796037
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71391794
113Nitrogen metabolism_Homo sapiens_hsa009100.71350399
114Long-term potentiation_Homo sapiens_hsa047200.70850188
115Glutathione metabolism_Homo sapiens_hsa004800.70641201
116Glutamatergic synapse_Homo sapiens_hsa047240.70177996
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68818181
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68127919
119Taste transduction_Homo sapiens_hsa047420.67944054
120Proteoglycans in cancer_Homo sapiens_hsa052050.67890495
121Huntingtons disease_Homo sapiens_hsa050160.67251926
122GABAergic synapse_Homo sapiens_hsa047270.66425120
123Caffeine metabolism_Homo sapiens_hsa002320.65220250
124Regulation of autophagy_Homo sapiens_hsa041400.65203797
125Long-term depression_Homo sapiens_hsa047300.64715279
126Other glycan degradation_Homo sapiens_hsa005110.64256790
127Estrogen signaling pathway_Homo sapiens_hsa049150.63128764
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62039929
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61462519
130Glioma_Homo sapiens_hsa052140.60815482
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60491657
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59603137
133Pyruvate metabolism_Homo sapiens_hsa006200.59452397
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59056090
135Tight junction_Homo sapiens_hsa045300.58929587
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58365689
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57962740
138Ovarian steroidogenesis_Homo sapiens_hsa049130.54137689
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53553777
140Selenocompound metabolism_Homo sapiens_hsa004500.53459528
141Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53388036
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50192539
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49304799
144Nicotine addiction_Homo sapiens_hsa050330.48878702
145Autoimmune thyroid disease_Homo sapiens_hsa053200.48260927
146One carbon pool by folate_Homo sapiens_hsa006700.44727064
147Fatty acid biosynthesis_Homo sapiens_hsa000610.40748338
148Glycerolipid metabolism_Homo sapiens_hsa005610.39414402
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39029497
150Graft-versus-host disease_Homo sapiens_hsa053320.38613695
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.38425591
152Morphine addiction_Homo sapiens_hsa050320.35971941
153Purine metabolism_Homo sapiens_hsa002300.35094591
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.33103855
155Cyanoamino acid metabolism_Homo sapiens_hsa004600.29945876
156Circadian rhythm_Homo sapiens_hsa047100.29599488
157Lysine degradation_Homo sapiens_hsa003100.27376808
158Basal transcription factors_Homo sapiens_hsa030220.26831013
159Cysteine and methionine metabolism_Homo sapiens_hsa002700.26125605
160Serotonergic synapse_Homo sapiens_hsa047260.25715442
161Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24342112
162Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24316924
163Allograft rejection_Homo sapiens_hsa053300.24274755
164Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24167677

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »