CYP2W1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte development (GO:0003334)8.63545852
2intestinal cholesterol absorption (GO:0030299)7.48724759
3plasma lipoprotein particle assembly (GO:0034377)7.15221705
4molting cycle (GO:0042303)7.05623797
5hair cycle (GO:0042633)7.05623797
6planar cell polarity pathway involved in neural tube closure (GO:0090179)6.82512520
7very-low-density lipoprotein particle assembly (GO:0034379)6.73833930
8desmosome organization (GO:0002934)6.67346130
9head development (GO:0060322)6.60472509
10regulation of cholesterol homeostasis (GO:2000188)6.59663678
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)6.22514558
12protein-lipid complex assembly (GO:0065005)6.17423586
13protein-lipid complex remodeling (GO:0034368)6.17267949
14macromolecular complex remodeling (GO:0034367)6.17267949
15plasma lipoprotein particle remodeling (GO:0034369)6.17267949
16peptidyl-glutamic acid carboxylation (GO:0017187)6.14581549
17protein carboxylation (GO:0018214)6.14581549
18proline metabolic process (GO:0006560)6.08423013
19protein heterotrimerization (GO:0070208)6.06296483
20low-density lipoprotein particle remodeling (GO:0034374)5.95952361
21high-density lipoprotein particle remodeling (GO:0034375)5.94927200
22plasma lipoprotein particle organization (GO:0071827)5.91106160
23reverse cholesterol transport (GO:0043691)5.90962921
24negative regulation of fibrinolysis (GO:0051918)5.84169767
25anatomical structure regression (GO:0060033)5.84125431
26cholesterol efflux (GO:0033344)5.83350962
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.82022974
28lung epithelium development (GO:0060428)5.71347719
29bone trabecula formation (GO:0060346)5.60059494
30protein-lipid complex subunit organization (GO:0071825)5.45283886
31regulation of cholesterol esterification (GO:0010872)5.41530203
32establishment of skin barrier (GO:0061436)5.15678622
33plasma lipoprotein particle clearance (GO:0034381)5.14534940
34intestinal absorption (GO:0050892)5.10252061
35lateral sprouting from an epithelium (GO:0060601)5.09097583
36oligosaccharide catabolic process (GO:0009313)4.95475597
37regulation of water loss via skin (GO:0033561)4.95157441
38negative regulation of cholesterol transport (GO:0032375)4.80237396
39negative regulation of sterol transport (GO:0032372)4.80237396
40regulation of hair follicle development (GO:0051797)4.78210833
41regulation of fibrinolysis (GO:0051917)4.77327674
42proline biosynthetic process (GO:0006561)4.75548768
43cell proliferation involved in metanephros development (GO:0072203)4.69336360
44non-canonical Wnt signaling pathway (GO:0035567)4.67244565
45regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.60565174
46G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.53556892
47cochlea morphogenesis (GO:0090103)4.53204491
48regulation of plasminogen activation (GO:0010755)4.44446638
49cellular zinc ion homeostasis (GO:0006882)4.40174295
50diacylglycerol metabolic process (GO:0046339)4.40064608
51regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.31891227
52Wnt signaling pathway, planar cell polarity pathway (GO:0060071)4.31456141
53regulation of bile acid biosynthetic process (GO:0070857)4.30818069
54sulfate transmembrane transport (GO:1902358)4.30569206
55purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.29998676
563-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.29998676
57cell-substrate junction assembly (GO:0007044)4.28511456
58positive regulation of fatty acid biosynthetic process (GO:0045723)4.27813512
59positive regulation of hair follicle development (GO:0051798)4.24971745
60positive regulation of hair cycle (GO:0042635)4.24971745
61skin morphogenesis (GO:0043589)4.20226495
62establishment of tissue polarity (GO:0007164)4.17994841
63establishment of planar polarity (GO:0001736)4.17994841
64tooth mineralization (GO:0034505)4.17231925
65trivalent inorganic anion homeostasis (GO:0072506)4.10998585
66phosphate ion homeostasis (GO:0055062)4.10998585
67mesenchyme morphogenesis (GO:0072132)4.09363494
68triglyceride homeostasis (GO:0070328)4.08939029
69acylglycerol homeostasis (GO:0055090)4.08939029
70enteric nervous system development (GO:0048484)4.06628312
71endodermal cell differentiation (GO:0035987)4.06466283
72regulation of apoptotic cell clearance (GO:2000425)4.06155331
73eyelid development in camera-type eye (GO:0061029)4.06087543
74regulation of establishment of planar polarity (GO:0090175)4.05851137
75phospholipid efflux (GO:0033700)4.03044116
76cell proliferation involved in kidney development (GO:0072111)4.02928788
77proximal/distal pattern formation (GO:0009954)4.02413136
78nephron tubule morphogenesis (GO:0072078)3.95765700
79nephron epithelium morphogenesis (GO:0072088)3.95765700
80negative regulation of axon extension involved in axon guidance (GO:0048843)3.94548789
81axon extension involved in axon guidance (GO:0048846)3.94374165
82neuron projection extension involved in neuron projection guidance (GO:1902284)3.94374165
83cholesterol homeostasis (GO:0042632)3.92353251
84sterol transport (GO:0015918)3.91478518
85cholesterol transport (GO:0030301)3.91478518
86outer ear morphogenesis (GO:0042473)3.91325367
87lung-associated mesenchyme development (GO:0060484)3.85389317
88skin development (GO:0043588)3.83985984
89sterol homeostasis (GO:0055092)3.83948626
90lipoprotein metabolic process (GO:0042157)3.83846690
91epidermis development (GO:0008544)3.78532865
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.75912816
93L-phenylalanine catabolic process (GO:0006559)3.75912816
94glutamate metabolic process (GO:0006536)3.72054005
95positive regulation of hormone metabolic process (GO:0032352)3.70574515
96collagen metabolic process (GO:0032963)3.69901353
97collagen catabolic process (GO:0030574)3.69807896
98keratinization (GO:0031424)3.68931884
99negative regulation of sodium ion transport (GO:0010766)3.66379457
100regulation of protein activation cascade (GO:2000257)3.65914429
101regulation of cholesterol biosynthetic process (GO:0045540)3.64921367
102regulation of complement activation (GO:0030449)3.63179375
103sulfate transport (GO:0008272)3.58854707
104transepithelial transport (GO:0070633)3.58581854
105negative regulation of cell fate specification (GO:0009996)3.56132000
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55175766
107L-phenylalanine metabolic process (GO:0006558)3.55175766
108wound healing, spreading of epidermal cells (GO:0035313)3.54198391
109receptor catabolic process (GO:0032801)3.52537904
110endocardial cushion morphogenesis (GO:0003203)3.47736749
111regulation of hair cycle (GO:0042634)3.47652693
112zinc ion homeostasis (GO:0055069)3.47568209
113positive regulation of steroid metabolic process (GO:0045940)3.47052178
114intermediate filament organization (GO:0045109)3.46808833
115multicellular organismal macromolecule metabolic process (GO:0044259)3.45385837
116positive regulation of odontogenesis (GO:0042482)3.42462993
117positive regulation of lipoprotein lipase activity (GO:0051006)3.41291009
118positive regulation of triglyceride lipase activity (GO:0061365)3.41291009
119bundle of His cell to Purkinje myocyte communication (GO:0086069)3.40614374
120multicellular organismal catabolic process (GO:0044243)3.39752657
121phospholipid homeostasis (GO:0055091)3.39024753
122lipid homeostasis (GO:0055088)3.38175457
123regulation of extracellular matrix disassembly (GO:0010715)3.38072013
124atrioventricular valve morphogenesis (GO:0003181)3.35287721
125multicellular organismal water homeostasis (GO:0050891)3.34598969
126negative regulation of digestive system process (GO:0060457)3.34557724
127epithelial cell fate commitment (GO:0072148)3.32123787
128stress fiber assembly (GO:0043149)3.30705952
129multicellular organismal metabolic process (GO:0044236)3.27827126
130blood coagulation, intrinsic pathway (GO:0007597)3.27070294
131cellular anion homeostasis (GO:0030002)3.24348490
132positive regulation of hormone biosynthetic process (GO:0046886)3.22976167
133negative regulation of lipase activity (GO:0060192)3.20789786
134peptidyl-glutamic acid modification (GO:0018200)3.20752069
135extracellular matrix disassembly (GO:0022617)3.19993724
136embryonic skeletal joint morphogenesis (GO:0060272)3.19912783
137positive regulation of epidermis development (GO:0045684)3.19619635
138anion homeostasis (GO:0055081)3.17563272
139positive regulation of fatty acid metabolic process (GO:0045923)3.14943350
140mesenchymal cell proliferation (GO:0010463)3.11858444
141collagen fibril organization (GO:0030199)3.11737853
142renal filtration (GO:0097205)3.09608337
143vitamin transmembrane transport (GO:0035461)3.08603942
144pattern specification involved in kidney development (GO:0061004)3.08471576
145renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.05263616
146negative regulation of keratinocyte proliferation (GO:0010839)3.04476700
147cell-cell junction maintenance (GO:0045217)3.03105606
148glutamine family amino acid biosynthetic process (GO:0009084)3.00677128
149dorsal/ventral axis specification (GO:0009950)2.99823895
150cell migration involved in heart development (GO:0060973)2.98400791
151digestive tract morphogenesis (GO:0048546)2.97740452
152negative regulation of axon guidance (GO:1902668)2.97426987
153branching involved in salivary gland morphogenesis (GO:0060445)2.97280206
154regulation of cholesterol metabolic process (GO:0090181)2.96913874
155glomerular filtration (GO:0003094)2.94851349
156regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.93925098
157embryonic camera-type eye development (GO:0031076)2.92510470
158cell junction maintenance (GO:0034331)2.92462667
159positive regulation of fatty acid beta-oxidation (GO:0032000)2.92284290
160drinking behavior (GO:0042756)2.92145836
161regulation of axon extension involved in axon guidance (GO:0048841)2.90892275
162negative regulation of catenin import into nucleus (GO:0035414)2.89793228
163low-density lipoprotein particle clearance (GO:0034383)2.89552595
164regulation of extracellular matrix organization (GO:1903053)2.89371088
165negative regulation of fatty acid transport (GO:2000192)2.89032717
166dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.88726864
167endocardial cushion development (GO:0003197)2.88483420
168negative regulation of chondrocyte differentiation (GO:0032331)2.86441615
169chondrocyte proliferation (GO:0035988)2.86164316
170positive regulation of gastrulation (GO:2000543)2.85494278
171negative regulation of Ras GTPase activity (GO:0034261)2.84887065
172extracellular fibril organization (GO:0043206)2.83276278
173peristalsis (GO:0030432)2.82977104
174artery smooth muscle contraction (GO:0014824)2.80907737
175negative regulation of cell fate commitment (GO:0010454)2.80457988
176positive regulation of smoothened signaling pathway (GO:0045880)2.80085355
177renal system development (GO:0072001)2.79979041
178positive regulation of epithelial to mesenchymal transition (GO:0010718)2.78872598
179acute-phase response (GO:0006953)2.78865614
180odontogenesis (GO:0042476)2.77554358
181hair follicle development (GO:0001942)2.76883703
182epidermal cell differentiation (GO:0009913)2.76797497
183embryonic retina morphogenesis in camera-type eye (GO:0060059)2.76117292
184glial cell migration (GO:0008347)2.76057669
185negative regulation of cartilage development (GO:0061037)2.75998414
186regulation of epidermis development (GO:0045682)2.75691890
187regulation of cardioblast differentiation (GO:0051890)2.75537030
188canonical Wnt signaling pathway (GO:0060070)2.75178440
189inner ear receptor cell development (GO:0060119)2.73162422
190renal absorption (GO:0070293)2.72651761
191regulation of metalloenzyme activity (GO:0048552)2.71991869
192establishment of apical/basal cell polarity (GO:0035089)2.71926238
193regulation of non-canonical Wnt signaling pathway (GO:2000050)2.71221400
194tonic smooth muscle contraction (GO:0014820)2.69069753
195negative regulation of embryonic development (GO:0045992)2.68984506
196polarized epithelial cell differentiation (GO:0030859)2.68184964
197keratinocyte differentiation (GO:0030216)2.67374458
198apoptotic process involved in morphogenesis (GO:0060561)2.66952183
199positive regulation of transforming growth factor beta production (GO:0071636)2.66630320
200hemidesmosome assembly (GO:0031581)11.4809893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.15948252
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.00877039
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.85552810
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.74966284
5FOXA2_19822575_ChIP-Seq_HepG2_Human3.42070252
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.41503182
7ZNF263_19887448_ChIP-Seq_K562_Human3.11216815
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.09844725
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.82769325
10HNF4A_19822575_ChIP-Seq_HepG2_Human2.72808344
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.72075332
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.60117208
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46414620
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.44238738
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.25774651
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25063708
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.20838020
18GATA4_25053715_ChIP-Seq_YYC3_Human2.17905964
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.16614078
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04579038
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04579038
22TP63_17297297_ChIP-ChIP_HaCaT_Human12.3738404
23* P68_20966046_ChIP-Seq_HELA_Human1.99525454
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96994644
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.92731019
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91194411
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.88142847
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.87989235
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.87148331
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.85145930
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84434728
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83106887
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.83028054
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.81718592
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80408646
36SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.74210673
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.73827752
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73443524
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73443524
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73443524
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73295837
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72779996
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70904018
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70636560
45GATA6_25053715_ChIP-Seq_YYC3_Human1.69185496
46* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68303571
47KDM2B_26808549_Chip-Seq_K562_Human1.67541637
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.65792047
49P63_26484246_Chip-Seq_KERATINOCYTES_Human1.65220152
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63074431
51* RARB_24833708_ChIP-Seq_LIVER_Mouse1.62323788
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60367311
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59708979
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58461156
55SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57904010
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.56725069
57LXR_22292898_ChIP-Seq_THP-1_Human1.55808737
58DROSHA_22980978_ChIP-Seq_HELA_Human1.54598502
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54190377
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53891624
61* BCL6_27268052_Chip-Seq_Bcells_Human1.53666551
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.53445518
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52024045
64* BCOR_27268052_Chip-Seq_Bcells_Human1.51292712
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.50806346
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49547649
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.49478988
68E2F1_20622854_ChIP-Seq_HELA_Human1.49327870
69* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49172342
70RARA_24833708_ChIP-Seq_LIVER_Mouse1.47037408
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46885078
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46802322
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46405664
74SMC4_20622854_ChIP-Seq_HELA_Human1.45559848
75RACK7_27058665_Chip-Seq_MCF-7_Human1.45317583
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44134217
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44054589
78PHF8_20622854_ChIP-Seq_HELA_Human1.43289115
79NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.41699104
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39797278
81CLOCK_20551151_ChIP-Seq_293T_Human1.38875950
82* RAC3_21632823_ChIP-Seq_H3396_Human1.38741683
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.37913462
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34439414
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34407618
86CTCF_27219007_Chip-Seq_Bcells_Human1.32995771
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32351278
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30901640
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.30006101
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.29223546
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28868318
92KDM2B_26808549_Chip-Seq_DND41_Human1.28697810
93RXRA_24833708_ChIP-Seq_LIVER_Mouse1.27247268
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.26501643
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25906115
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.25666119
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24255959
98* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24016196
99OCT4_20526341_ChIP-Seq_ESCs_Human1.23069345
100CDX2_20551321_ChIP-Seq_CACO-2_Human1.22993299
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21202183
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21071251
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20633358
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20633358
105KLF5_25053715_ChIP-Seq_YYC3_Human1.20014729
106ZNF274_21170338_ChIP-Seq_K562_Hela1.19571473
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.19477813
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.17474007
109EGR1_19374776_ChIP-ChIP_THP-1_Human1.17432860
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17289700
111ISL1_27105846_Chip-Seq_CPCs_Mouse1.16721829
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16071402
113* TCF7_22412390_ChIP-Seq_EML_Mouse1.16046895
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15878322
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.15665203
116MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14702821
117DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14314890
118SA1_27219007_Chip-Seq_ERYTHROID_Human1.13388507
119FOXH1_21741376_ChIP-Seq_ESCs_Human1.12784944
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12328566
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07862116
122KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06828621
123ERA_21632823_ChIP-Seq_H3396_Human1.06633862
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04000840
125ESR1_20079471_ChIP-ChIP_T-47D_Human1.03769436
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02838757
127ELF1_20517297_ChIP-Seq_JURKAT_Human1.02462304
128P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01228411
129* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00610575
130JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99320760
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98857493
132TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96730642
133TP63_19390658_ChIP-ChIP_HaCaT_Human0.96650447
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96490342
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96037646
136* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95654456
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95470562
138* P300_27268052_Chip-Seq_Bcells_Human0.94714423
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.94087166
140TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94083583
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92795973
142SA1_27219007_Chip-Seq_Bcells_Human0.92773574
143* FOXP1_21924763_ChIP-Seq_HESCs_Human0.92648234
144* TAF2_19829295_ChIP-Seq_ESCs_Human0.92633491
145PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92165088
146CEBPB_22108803_ChIP-Seq_LS180_Human0.91771075
147TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91023755
148PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90585646
149CREB1_26743006_Chip-Seq_LNCaP_Human0.90414322
150ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89991873
151ATF3_27146783_Chip-Seq_COLON_Human0.89765724
152SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89713561
153* TP63_22573176_ChIP-Seq_HFKS_Human0.89621325
154TP53_22127205_ChIP-Seq_IMR90_Human0.89616221
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.89308354
156UBF1/2_26484160_Chip-Seq_HMECs_Human0.88639516
157SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88373449
158OCT4_19829295_ChIP-Seq_ESCs_Human0.87966610
159* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87878008
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86650806
161SOX2_20726797_ChIP-Seq_SW620_Human0.85685915
162BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85205419
163WT1_19549856_ChIP-ChIP_CCG9911_Human0.84940710
164FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84767594
165* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84501067
166POU5F1_16518401_ChIP-PET_MESCs_Mouse0.84426731
167SALL1_21062744_ChIP-ChIP_HESCs_Human0.83872359
168POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83864542
169MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83654723
170MYC_27129775_Chip-Seq_CORNEA_Mouse0.83438907
171ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81547858
172OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80072585
173CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79932563
174CBX2_27304074_Chip-Seq_ESCs_Mouse0.79778780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.27520540
2MP0000579_abnormal_nail_morphology4.87349421
3MP0002139_abnormal_hepatobiliary_system4.67844669
4MP0005275_abnormal_skin_tensile4.52335745
5MP0003705_abnormal_hypodermis_morpholog4.17743971
6MP0003195_calcinosis4.13822412
7MP0010329_abnormal_lipoprotein_level3.95844962
8MP0005365_abnormal_bile_salt3.85061270
9MP0010234_abnormal_vibrissa_follicle3.75695531
10MP0000383_abnormal_hair_follicle3.59518098
11MP0002060_abnormal_skin_morphology3.31250555
12MP0008438_abnormal_cutaneous_collagen3.22973300
13MP0008875_abnormal_xenobiotic_pharmacok3.16690931
14MP0000762_abnormal_tongue_morphology3.16524282
15MP0003172_abnormal_lysosome_physiology3.15508333
16MP0010678_abnormal_skin_adnexa3.07705826
17MP0002234_abnormal_pharynx_morphology3.02078717
18MP0009053_abnormal_anal_canal2.99233014
19MP0001243_abnormal_dermal_layer2.98822067
20MP0001666_abnormal_nutrient_absorption2.86162754
21MP0000467_abnormal_esophagus_morphology2.78420225
22MP0010030_abnormal_orbit_morphology2.77191389
23MP0002089_abnormal_postnatal_growth/wei2.75774419
24MP0002098_abnormal_vibrissa_morphology2.70275860
25MP0002796_impaired_skin_barrier2.60181248
26MP0000462_abnormal_digestive_system2.60127993
27MP0003941_abnormal_skin_development2.51851577
28MP0001216_abnormal_epidermal_layer2.50909474
29MP0005409_darkened_coat_color2.48995944
30MP0002254_reproductive_system_inflammat2.45780639
31MP0004381_abnormal_hair_follicle2.40679266
32MP0003123_paternal_imprinting2.39604802
33MP0005085_abnormal_gallbladder_physiolo2.38002783
34MP0009780_abnormal_chondrocyte_physiolo2.28645251
35MP0004272_abnormal_basement_membrane2.18384498
36MP0003453_abnormal_keratinocyte_physiol2.10790371
37MP0006054_spinal_hemorrhage2.02517867
38MP0010771_integument_phenotype2.02172973
39MP0005501_abnormal_skin_physiology2.00650306
40MP0000377_abnormal_hair_follicle1.99813013
41MP0000537_abnormal_urethra_morphology1.86020967
42MP0004043_abnormal_pH_regulation1.85768851
43MP0000566_synostosis1.83336635
44MP0000647_abnormal_sebaceous_gland1.81778253
45MP0002249_abnormal_larynx_morphology1.76432928
46MP0001849_ear_inflammation1.72287909
47MP0000427_abnormal_hair_cycle1.66352104
48MP0003252_abnormal_bile_duct1.66143262
49MP0005332_abnormal_amino_acid1.65063203
50MP0002638_abnormal_pupillary_reflex1.64343802
51MP0005167_abnormal_blood-brain_barrier1.64262028
52MP0005377_hearing/vestibular/ear_phenot1.60130249
53MP0003878_abnormal_ear_physiology1.60130249
54MP0002118_abnormal_lipid_homeostasis1.59178695
55MP0003755_abnormal_palate_morphology1.57610793
56MP0003136_yellow_coat_color1.56986643
57MP0003879_abnormal_hair_cell1.56706897
58MP0005257_abnormal_intraocular_pressure1.55697723
59MP0002160_abnormal_reproductive_system1.54117157
60MP0000049_abnormal_middle_ear1.51931980
61MP0002876_abnormal_thyroid_physiology1.47912147
62MP0008789_abnormal_olfactory_epithelium1.43673291
63MP0003121_genomic_imprinting1.43497545
64MP0003385_abnormal_body_wall1.42888421
65MP0005408_hypopigmentation1.40177714
66MP0005645_abnormal_hypothalamus_physiol1.39473406
67MP0001270_distended_abdomen1.39371685
68MP0005451_abnormal_body_composition1.38106448
69MP0003283_abnormal_digestive_organ1.35124203
70MP0000609_abnormal_liver_physiology1.32413648
71MP0000639_abnormal_adrenal_gland1.30255352
72MP0001340_abnormal_eyelid_morphology1.28465392
73MP0001756_abnormal_urination1.27943405
74MP0009931_abnormal_skin_appearance1.27355947
75MP0005058_abnormal_lysosome_morphology1.24562224
76MP0002932_abnormal_joint_morphology1.22005675
77MP0005367_renal/urinary_system_phenotyp1.21546588
78MP0000516_abnormal_urinary_system1.21546588
79MP0005499_abnormal_olfactory_system1.21290233
80MP0005394_taste/olfaction_phenotype1.21290233
81MP0005636_abnormal_mineral_homeostasis1.17949485
82MP0009250_abnormal_appendicular_skeleto1.17281241
83MP0004264_abnormal_extraembryonic_tissu1.17252316
84MP0002938_white_spotting1.16555244
85MP0002111_abnormal_tail_morphology1.14108124
86MP0002233_abnormal_nose_morphology1.12764723
87MP0004019_abnormal_vitamin_homeostasis1.12030902
88MP0001765_abnormal_ion_homeostasis1.11646051
89MP0002282_abnormal_trachea_morphology1.10273942
90MP0001764_abnormal_homeostasis1.07491086
91MP0003566_abnormal_cell_adhesion1.07262833
92MP0009384_cardiac_valve_regurgitation1.06234952
93MP0003122_maternal_imprinting1.06070061
94MP0005508_abnormal_skeleton_morphology1.03798945
95MP0003567_abnormal_fetal_cardiomyocyte1.02682420
96MP0000367_abnormal_coat/_hair1.02330634
97MP0003937_abnormal_limbs/digits/tail_de0.99807774
98MP0001191_abnormal_skin_condition0.99539783
99MP0000432_abnormal_head_morphology0.98528933
100MP0002909_abnormal_adrenal_gland0.97247871
101MP0001664_abnormal_digestion0.96142089
102MP0000013_abnormal_adipose_tissue0.93896945
103MP0005076_abnormal_cell_differentiation0.93630851
104MP0003935_abnormal_craniofacial_develop0.92458681
105MP0002109_abnormal_limb_morphology0.92181257
106MP0000428_abnormal_craniofacial_morphol0.89879792
107MP0002132_abnormal_respiratory_system0.89703160
108MP0003942_abnormal_urinary_system0.88686108
109MP0003943_abnormal_hepatobiliary_system0.88630657
110MP0009840_abnormal_foam_cell0.88401269
111MP0003279_aneurysm0.88377948
112MP0000613_abnormal_salivary_gland0.88215404
113MP0002177_abnormal_outer_ear0.88006730
114MP0005448_abnormal_energy_balance0.87764253
115MP0009643_abnormal_urine_homeostasis0.87078210
116MP0003115_abnormal_respiratory_system0.86133850
117MP0001958_emphysema0.85658962
118MP0004147_increased_porphyrin_level0.85484052
119MP0000538_abnormal_urinary_bladder0.81644517
120MP0002877_abnormal_melanocyte_morpholog0.81348759
121MP0005551_abnormal_eye_electrophysiolog0.79532330
122MP0005187_abnormal_penis_morphology0.78496225
123MP0005319_abnormal_enzyme/_coenzyme0.78350759
124MP0005503_abnormal_tendon_morphology0.77800062
125MP0005389_reproductive_system_phenotype0.77538803
126MP0005379_endocrine/exocrine_gland_phen0.76920851
127MP0000534_abnormal_ureter_morphology0.76869550
128MP0003953_abnormal_hormone_level0.76507247
129MP0003119_abnormal_digestive_system0.76494664
130MP0002116_abnormal_craniofacial_bone0.75067116
131MP0002896_abnormal_bone_mineralization0.74740063
132MP0003315_abnormal_perineum_morphology0.74166478
133MP0005084_abnormal_gallbladder_morpholo0.72912861
134MP0004858_abnormal_nervous_system0.72872078
135MP0009642_abnormal_blood_homeostasis0.72722239
136MP0006292_abnormal_olfactory_placode0.72676150
137MP0000598_abnormal_liver_morphology0.72297498
138MP0000733_abnormal_muscle_development0.72220848
139MP0000003_abnormal_adipose_tissue0.70197152
140MP0002078_abnormal_glucose_homeostasis0.69818702
141MP0005646_abnormal_pituitary_gland0.69317481
142MP0002115_abnormal_skeleton_extremities0.68642137
143MP0010352_gastrointestinal_tract_polyps0.67813933
144MP0005220_abnormal_exocrine_pancreas0.67636829
145MP0001542_abnormal_bone_strength0.66735360
146MP0008961_abnormal_basal_metabolism0.66069905
147MP0002114_abnormal_axial_skeleton0.65908939
148MP0004133_heterotaxia0.64804384
149MP0002751_abnormal_autonomic_nervous0.60169745
150MP0004134_abnormal_chest_morphology0.59288828
151MP0000470_abnormal_stomach_morphology0.57398204
152MP0008872_abnormal_physiological_respon0.57173620
153MP0005023_abnormal_wound_healing0.56752790
154MP0000163_abnormal_cartilage_morphology0.56645796
155MP0004947_skin_inflammation0.56195113
156MP0005375_adipose_tissue_phenotype0.55362394
157MP0002697_abnormal_eye_size0.54711639
158MP0001286_abnormal_eye_development0.54673980
159MP0000678_abnormal_parathyroid_gland0.54440670
160MP0001986_abnormal_taste_sensitivity0.54176133
161MP0001661_extended_life_span0.54038513
162MP0005670_abnormal_white_adipose0.52605807
163MP0003183_abnormal_peptide_metabolism0.51343828
164MP0000477_abnormal_intestine_morphology0.50845178
165MP0001324_abnormal_eye_pigmentation0.50745662
166MP0003632_abnormal_nervous_system0.50639028
167MP0002166_altered_tumor_susceptibility0.50082236
168MP0001915_intracranial_hemorrhage0.49655111
169MP0000465_gastrointestinal_hemorrhage0.49442986
170MP0002557_abnormal_social/conspecific_i0.49331759
171MP0003718_maternal_effect0.49127626
172MP0002092_abnormal_eye_morphology0.47740662
173MP0001851_eye_inflammation0.47585127
174MP0003638_abnormal_response/metabolism_0.47405312
175MP0003011_delayed_dark_adaptation0.47282247

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.03849614
2Atrophic scars (HP:0001075)7.42773709
3Fragile skin (HP:0001030)7.32789610
4Joint hemorrhage (HP:0005261)5.97150917
5Hemorrhage of the eye (HP:0011885)5.43532505
6Prolonged partial thromboplastin time (HP:0003645)5.19825345
7Short 4th metacarpal (HP:0010044)5.17627583
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.17627583
9Down-sloping shoulders (HP:0200021)5.16526252
10Xanthomatosis (HP:0000991)5.02054002
11Premature rupture of membranes (HP:0001788)5.00655176
12Abnormality of the parietal bone (HP:0002696)4.79916435
13Thick nail (HP:0001805)4.58392274
14Fragile nails (HP:0001808)4.56187169
15Plantar hyperkeratosis (HP:0007556)4.51389750
16Hypobetalipoproteinemia (HP:0003563)4.30976652
17Neoplasm of the heart (HP:0100544)4.22722736
18Hypercholesterolemia (HP:0003124)4.10880764
19Ankyloglossia (HP:0010296)4.07905155
20Abnormality of the 4th metacarpal (HP:0010012)3.83685291
21Ridged nail (HP:0001807)3.69637642
22Palmoplantar hyperkeratosis (HP:0000972)3.64464731
23Malnutrition (HP:0004395)3.54945517
24Absent eyelashes (HP:0000561)3.51746650
25Vaginal fistula (HP:0004320)3.47278893
26Abnormality of aromatic amino acid family metabolism (HP:0004338)3.43433610
27Palmar hyperkeratosis (HP:0010765)3.41071593
28Pili torti (HP:0003777)3.37088665
29Onycholysis (HP:0001806)3.33321096
30Late onset (HP:0003584)3.30926405
31Increased connective tissue (HP:0009025)3.24618749
32Hypotrichosis (HP:0001006)3.21928137
33Abnormality of the nasal septum (HP:0000419)3.16544608
34Alopecia of scalp (HP:0002293)3.10735878
35Epidermoid cyst (HP:0200040)3.09898561
36Peritonitis (HP:0002586)3.09751757
37Nail dystrophy (HP:0008404)3.09662915
38Hyperglycinemia (HP:0002154)3.09635199
39Broad alveolar ridges (HP:0000187)3.07429495
40Abnormality of the distal phalanx of the thumb (HP:0009617)3.07018001
41Abnormality of carpal bone ossification (HP:0006257)3.05449362
42Bladder diverticulum (HP:0000015)3.04826046
43Abnormal ossification of hand bones (HP:0005921)3.04615135
44Follicular hyperkeratosis (HP:0007502)3.03802432
45Morphological abnormality of the middle ear (HP:0008609)2.99281828
46Irregular epiphyses (HP:0010582)2.98185309
47Woolly hair (HP:0002224)2.96552709
48Flat acetabular roof (HP:0003180)2.96247962
49Supernumerary ribs (HP:0005815)2.95563343
50Abnormality of oral frenula (HP:0000190)2.95499432
51Short phalanx of the thumb (HP:0009660)2.94182815
52Broad palm (HP:0001169)2.93212342
53Hypolipoproteinemia (HP:0010981)2.89127894
54Abnormal hand bone ossification (HP:0010660)2.88861403
55Ankle contracture (HP:0006466)2.86622261
56Hypophosphatemic rickets (HP:0004912)2.86570862
57Small epiphyses (HP:0010585)2.83153016
58Type 1 muscle fiber predominance (HP:0003803)2.80320369
59Neoplasm of the oral cavity (HP:0100649)2.73876548
60Supernumerary bones of the axial skeleton (HP:0009144)2.70159864
61Abnormality of the distal phalanges of the toes (HP:0010182)2.67245602
62Conjunctival hamartoma (HP:0100780)2.67234480
63Protrusio acetabuli (HP:0003179)2.64439991
64Menorrhagia (HP:0000132)2.63776603
65Pigmentary retinal degeneration (HP:0001146)2.62402244
66Bronchomalacia (HP:0002780)2.62187647
67Complement deficiency (HP:0004431)2.60729830
68Slender build (HP:0001533)2.58481650
69Medulloblastoma (HP:0002885)2.57126231
70Abnormality of the common coagulation pathway (HP:0010990)2.56653971
71Potter facies (HP:0002009)2.53124368
72Facial shape deformation (HP:0011334)2.53124368
73Widely patent fontanelles and sutures (HP:0004492)2.49187386
74Blepharitis (HP:0000498)2.48087105
75Distal lower limb muscle weakness (HP:0009053)2.46937553
76Abnormality of the vitreous humor (HP:0004327)2.46744048
77Natal tooth (HP:0000695)2.46576257
78Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.43527596
79Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.42748851
80Spontaneous abortion (HP:0005268)2.42022770
81Intrahepatic cholestasis (HP:0001406)2.39999426
82Soft skin (HP:0000977)2.39767118
83Flared iliac wings (HP:0002869)2.38914495
84Abnormal blistering of the skin (HP:0008066)2.37609895
85Shallow orbits (HP:0000586)2.36556016
86Abnormality of serine family amino acid metabolism (HP:0010894)2.35131564
87Abnormality of glycine metabolism (HP:0010895)2.35131564
88Short femoral neck (HP:0100864)2.34581687
89Mildly elevated creatine phosphokinase (HP:0008180)2.34129859
90Deviation of the hallux (HP:0010051)2.34087810
91Deformed sella turcica (HP:0002681)2.33936529
92Enlarged kidneys (HP:0000105)2.33865025
93Hypoalphalipoproteinemia (HP:0003233)2.33222557
94Hallux valgus (HP:0001822)2.31048570
95Abnormality of the lumbar spine (HP:0100712)2.30658342
96Pancreatic islet-cell hyperplasia (HP:0004510)2.30619324
97Abnormal tarsal ossification (HP:0008369)2.29614034
98Abnormality of monocarboxylic acid metabolism (HP:0010996)2.29223576
99Aplasia cutis congenita (HP:0001057)2.28918563
100Vascular calcification (HP:0004934)2.27893517
101Abnormality of the neuromuscular junction (HP:0003398)2.25485575
102Fatigable weakness (HP:0003473)2.25485575
103Obstructive sleep apnea (HP:0002870)2.25207747
104Renovascular hypertension (HP:0100817)2.22737195
105Spinal rigidity (HP:0003306)2.19450927
106Hypoplasia of dental enamel (HP:0006297)2.18978665
107Neonatal short-limb short stature (HP:0008921)2.18547660
108Alacrima (HP:0000522)2.18163437
109Conical tooth (HP:0000698)2.17604150
110Epiphyseal dysplasia (HP:0002656)2.16480236
111Neonatal death (HP:0003811)2.15896708
112Acanthocytosis (HP:0001927)2.15015810
113Bowel diverticulosis (HP:0005222)2.14680920
114Advanced eruption of teeth (HP:0006288)2.13054608
115Hamartoma (HP:0010566)2.11210822
116Glomerulonephritis (HP:0000099)2.10992684
117Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10587328
118Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10368375
119Nonimmune hydrops fetalis (HP:0001790)2.10250826
120Renal duplication (HP:0000075)2.10144934
121Aortic dissection (HP:0002647)2.09966620
122Aplasia/hypoplasia of the femur (HP:0005613)2.09832626
123Delayed epiphyseal ossification (HP:0002663)2.09420511
124Abnormality of the wing of the ilium (HP:0011867)2.08210052
125Abnormality of the peritoneum (HP:0002585)2.06357735
126Cerebral aneurysm (HP:0004944)2.06324375
127Gonadal dysgenesis (HP:0000133)2.04523827
128Genu recurvatum (HP:0002816)2.04018802
129Hyperacusis (HP:0010780)2.03836975
130Limited elbow extension (HP:0001377)2.00878731
131Infantile muscular hypotonia (HP:0008947)2.00570850
132Hyperlipoproteinemia (HP:0010980)2.00539377
133Cheilitis (HP:0100825)2.00522958
134Delayed CNS myelination (HP:0002188)2.00460470
135Milia (HP:0001056)10.4740755
136Venous insufficiency (HP:0005293)1.99432545
137Rectal prolapse (HP:0002035)1.99321867
138Bifid scrotum (HP:0000048)1.98762152
139Pendular nystagmus (HP:0012043)1.95878964
140Absent eyebrow (HP:0002223)1.94778163
141Rectal fistula (HP:0100590)1.94212093
142Rectovaginal fistula (HP:0000143)1.94212093
143Purpura (HP:0000979)1.92890545
144Pustule (HP:0200039)1.92752712
145Hydroxyprolinuria (HP:0003080)1.92106377
146Abnormality of proline metabolism (HP:0010907)1.92106377
147Skin pits (HP:0100276)1.91144665
148Abnormal hair laboratory examination (HP:0003328)1.90861241
149Hyperglycinuria (HP:0003108)1.90709366
150Right ventricular cardiomyopathy (HP:0011663)1.90165407
151Lip pit (HP:0100267)1.90042113
152Cardiovascular calcification (HP:0011915)1.89344638
153Hepatoblastoma (HP:0002884)1.88324275
154Opisthotonus (HP:0002179)1.87220981
155Selective tooth agenesis (HP:0001592)1.87149916
156Lymphangioma (HP:0100764)1.86954876
157Megaloblastic anemia (HP:0001889)1.86842480
158Intestinal fistula (HP:0100819)1.86554949
159Mitral valve prolapse (HP:0001634)1.86085482
160Asymmetry of the thorax (HP:0001555)1.85231055
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84965289
162Absent epiphyses (HP:0010577)1.84965289
163Venous abnormality (HP:0002624)1.84824063
164Sparse lateral eyebrow (HP:0005338)1.83390575
165Wide cranial sutures (HP:0010537)1.82278741
166Vitreoretinal degeneration (HP:0000655)1.80030987
167Turricephaly (HP:0000262)1.78735128
168Overriding aorta (HP:0002623)1.75798227
169Congenital, generalized hypertrichosis (HP:0004540)1.75533991
170Mitral stenosis (HP:0001718)1.74412574
171Sprengel anomaly (HP:0000912)1.73501922
172Abnormality of the sella turcica (HP:0002679)1.73275665
173Basal cell carcinoma (HP:0002671)1.72974659
174Ulnar bowing (HP:0003031)1.72618569
175Coronal craniosynostosis (HP:0004440)1.72375663
176Visceral angiomatosis (HP:0100761)1.72336539
177Abnormality of the middle phalanges of the toes (HP:0010183)1.71578256
178Atresia of the external auditory canal (HP:0000413)1.71026688
179Fibrous tissue neoplasm (HP:0012316)1.70999007
180Hepatocellular carcinoma (HP:0001402)1.69744014
181Sparse scalp hair (HP:0002209)1.68848217
182Fibroma (HP:0010614)1.68588746
183Neoplasm of striated muscle (HP:0009728)1.68111004
184Abnormality of complement system (HP:0005339)1.67004743
185Fat malabsorption (HP:0002630)1.65901591
186Flattened epiphyses (HP:0003071)1.65155622
187Abnormality of the costochondral junction (HP:0000919)1.64719728
188Decreased lacrimation (HP:0000633)1.63970316
189Stridor (HP:0010307)1.63372069
190Urinary glycosaminoglycan excretion (HP:0003541)1.62683260
191Mucopolysacchariduria (HP:0008155)1.62683260

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.19188818
2WNK44.65745927
3TRIB33.46079890
4EEF2K3.37435900
5EPHB23.09494051
6TAOK13.07875993
7TYRO33.04285012
8LATS12.77251313
9ADRBK22.74872183
10RIPK12.46613134
11EPHA22.41996931
12MST1R2.24970367
13PKN22.24013707
14SIK12.20549888
15MAPK111.99822537
16FER1.97410090
17ERN11.79565160
18LMTK21.78806159
19FGFR21.74372873
20DYRK1B1.73169756
21PTK61.71210300
22MAP2K21.70635702
23RPS6KB21.70442518
24MAPK151.70365330
25PRKCI1.65691721
26EPHB11.65133270
27MAP3K31.62143512
28PIK3CA1.61517099
29PDGFRA1.58949969
30PRKAA21.57440651
31STK391.56968877
32MET1.52110795
33HIPK21.48304387
34BMX1.45462279
35LATS21.42380715
36NME11.39260748
37SIK21.37810038
38CDK121.31051161
39RPS6KA41.29644933
40MAP3K71.27595922
41MAP3K111.27434407
42DDR21.25376244
43AKT31.22627183
44FRK1.20500590
45ACVR1B1.17833419
46PRKAA11.13444818
47WNK11.12165767
48PDPK11.08544021
49MUSK1.02871924
50MAPKAPK31.02639316
51CDK60.99885999
52TRPM70.94423760
53RET0.91337227
54ICK0.89417311
55SMG10.87674631
56CLK10.85458486
57IRAK30.85145977
58RPS6KA20.81714147
59CAMK40.81349816
60NUAK10.80801271
61PAK30.80324971
62PRKG20.80261735
63CHUK0.80066003
64PAK20.78993104
65DMPK0.78850895
66FGFR10.77839042
67OXSR10.76392495
68PDK10.75601689
69PRKD20.75474069
70EPHA30.72557614
71TTN0.70601362
72PDGFRB0.70369012
73CDC42BPA0.69289097
74CDK70.69152320
75MAP3K10.68029751
76PAK40.67885115
77NEK20.67276336
78MAPK120.66961411
79GRK10.66807282
80ILK0.65549388
81MARK20.65226714
82BMPR1B0.64220368
83PTK20.63036722
84MAP2K10.62521065
85EPHA40.61624235
86MAPK70.60535441
87SGK2230.56064183
88SGK4940.56064183
89ERBB20.55561422
90MAPKAPK20.55078269
91MTOR0.54316968
92MAP3K20.53962542
93MAP4K10.53117051
94ROCK10.52780088
95CAMK1D0.52698776
96MAPKAPK50.52205566
97RPS6KA10.50956655
98PKN10.50071705
99ALK0.49301665
100BCR0.49213330
101ADRBK10.49178094
102DAPK20.48875886
103PIM20.47753106
104MAP2K40.46992107
105MELK0.45514650
106PRKCH0.45317784
107GRK60.44761862
108RPS6KB10.44699517
109DYRK30.43356236
110MAP2K60.42950561
111LRRK20.42403001
112PRKCZ0.42126000
113SGK10.41343955
114FGFR40.40974288
115RPS6KL10.40753529
116RPS6KC10.40753529
117DYRK20.40648551
118NTRK20.40579058
119PRKD10.40234408
120FGFR30.39741457
121CSNK1E0.39570424
122CDK80.39562914
123MAPK10.39171644
124BTK0.38680404
125ITK0.38407591
126PTK2B0.38118503
127FGR0.35812415
128CDK40.34898334
129RPS6KA60.31698776
130MAPK40.31231145
131CSNK1A10.30904461
132MATK0.30841937
133CSNK1A1L0.30319191
134SRC0.30290045
135GSK3A0.30118445
136DAPK30.30099010
137MAPK90.29922194
138MAPK80.29438668
139CSF1R0.29082541
140STK30.28937370
141STK110.28805183
142CSNK1D0.27230979
143PRKACG0.27212713
144STK38L0.27120888
145PHKG20.25768818
146PHKG10.25768818
147NTRK30.23834055
148MAPK30.22295941

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052176.56304148
2Hedgehog signaling pathway_Homo sapiens_hsa043405.97174845
3Complement and coagulation cascades_Homo sapiens_hsa046103.54448973
4Other glycan degradation_Homo sapiens_hsa005113.47829834
5Fat digestion and absorption_Homo sapiens_hsa049753.37070532
6ECM-receptor interaction_Homo sapiens_hsa045123.28278985
7Protein digestion and absorption_Homo sapiens_hsa049743.24126471
8Steroid biosynthesis_Homo sapiens_hsa001002.97136049
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.79989830
10Vitamin digestion and absorption_Homo sapiens_hsa049772.78094847
11Notch signaling pathway_Homo sapiens_hsa043302.62670980
12Sulfur metabolism_Homo sapiens_hsa009202.52814209
13Hippo signaling pathway_Homo sapiens_hsa043902.37480883
14Melanogenesis_Homo sapiens_hsa049162.20189522
15Arginine biosynthesis_Homo sapiens_hsa002202.20025351
16Histidine metabolism_Homo sapiens_hsa003402.17655286
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16111075
18Arginine and proline metabolism_Homo sapiens_hsa003302.13741367
19Glycosaminoglycan degradation_Homo sapiens_hsa005312.11885855
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05395281
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05245189
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.01535789
23PPAR signaling pathway_Homo sapiens_hsa033201.89296349
24Amoebiasis_Homo sapiens_hsa051461.84611705
25ABC transporters_Homo sapiens_hsa020101.83355579
26Proteoglycans in cancer_Homo sapiens_hsa052051.81810512
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75985765
28Wnt signaling pathway_Homo sapiens_hsa043101.73878725
29Axon guidance_Homo sapiens_hsa043601.73192823
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68702587
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64934867
32Focal adhesion_Homo sapiens_hsa045101.57289336
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54596884
34Phenylalanine metabolism_Homo sapiens_hsa003601.52309078
35Pathways in cancer_Homo sapiens_hsa052001.51741507
36Small cell lung cancer_Homo sapiens_hsa052221.50751082
37Sphingolipid metabolism_Homo sapiens_hsa006001.50486522
38Fatty acid degradation_Homo sapiens_hsa000711.43604871
39Glycerolipid metabolism_Homo sapiens_hsa005611.41626579
40Fatty acid metabolism_Homo sapiens_hsa012121.40306101
41Nitrogen metabolism_Homo sapiens_hsa009101.40249179
42N-Glycan biosynthesis_Homo sapiens_hsa005101.33488471
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32360518
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30153855
45Fatty acid biosynthesis_Homo sapiens_hsa000611.29748668
46Butanoate metabolism_Homo sapiens_hsa006501.29319106
47Peroxisome_Homo sapiens_hsa041461.27146888
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.23694028
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18076288
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16483631
51Fructose and mannose metabolism_Homo sapiens_hsa000511.15829366
52One carbon pool by folate_Homo sapiens_hsa006701.13833602
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13441694
54Sulfur relay system_Homo sapiens_hsa041221.11928272
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11703542
56MicroRNAs in cancer_Homo sapiens_hsa052061.11169371
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.10206309
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09308477
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05881856
60Tryptophan metabolism_Homo sapiens_hsa003801.04376935
61Adherens junction_Homo sapiens_hsa045201.02646244
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02363656
63Renin-angiotensin system_Homo sapiens_hsa046141.00248950
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00155647
65Chemical carcinogenesis_Homo sapiens_hsa052040.99810904
66Thyroid hormone synthesis_Homo sapiens_hsa049180.98978180
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96319498
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95883486
69Starch and sucrose metabolism_Homo sapiens_hsa005000.95812385
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95572553
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94998742
72Tyrosine metabolism_Homo sapiens_hsa003500.91927666
73Vitamin B6 metabolism_Homo sapiens_hsa007500.89561489
74Platelet activation_Homo sapiens_hsa046110.89529752
75Acute myeloid leukemia_Homo sapiens_hsa052210.89489541
76TGF-beta signaling pathway_Homo sapiens_hsa043500.88523990
77HTLV-I infection_Homo sapiens_hsa051660.87961222
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84226381
79Endometrial cancer_Homo sapiens_hsa052130.83857663
80Thyroid cancer_Homo sapiens_hsa052160.83306853
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81884197
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81548932
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80743210
84Dilated cardiomyopathy_Homo sapiens_hsa054140.80454228
85Chronic myeloid leukemia_Homo sapiens_hsa052200.78530171
86Bladder cancer_Homo sapiens_hsa052190.78342840
87Galactose metabolism_Homo sapiens_hsa000520.77883146
88Gap junction_Homo sapiens_hsa045400.77546811
89Pyruvate metabolism_Homo sapiens_hsa006200.75220202
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74783860
91Dorso-ventral axis formation_Homo sapiens_hsa043200.74488892
92Toxoplasmosis_Homo sapiens_hsa051450.72732401
93Prostate cancer_Homo sapiens_hsa052150.72312591
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70400413
95Rap1 signaling pathway_Homo sapiens_hsa040150.70339173
96Cocaine addiction_Homo sapiens_hsa050300.70301911
97Bile secretion_Homo sapiens_hsa049760.70198227
98Tight junction_Homo sapiens_hsa045300.69757701
99Renin secretion_Homo sapiens_hsa049240.69288877
100Circadian entrainment_Homo sapiens_hsa047130.66387726
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65796448
102VEGF signaling pathway_Homo sapiens_hsa043700.64745726
103Insulin resistance_Homo sapiens_hsa049310.64592172
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64077827
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63710179
106Lysine degradation_Homo sapiens_hsa003100.62836752
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62663689
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62157807
109Colorectal cancer_Homo sapiens_hsa052100.61959857
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61531813
111Propanoate metabolism_Homo sapiens_hsa006400.61235304
112Biosynthesis of amino acids_Homo sapiens_hsa012300.60364169
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60316780
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60155312
115Melanoma_Homo sapiens_hsa052180.59367806
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.58124197
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.57443916
118Glioma_Homo sapiens_hsa052140.56843493
119Renal cell carcinoma_Homo sapiens_hsa052110.55026680
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.54849036
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54634283
122Glucagon signaling pathway_Homo sapiens_hsa049220.53977594
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53644120
124Prion diseases_Homo sapiens_hsa050200.51184631
125Ether lipid metabolism_Homo sapiens_hsa005650.49139059
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.49124457
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46899186
128Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46707502
129AMPK signaling pathway_Homo sapiens_hsa041520.46357991
130Metabolic pathways_Homo sapiens_hsa011000.46327295
131Staphylococcus aureus infection_Homo sapiens_hsa051500.46137374
132GnRH signaling pathway_Homo sapiens_hsa049120.44380498
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44037590
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43789648
135Estrogen signaling pathway_Homo sapiens_hsa049150.42234133
136beta-Alanine metabolism_Homo sapiens_hsa004100.41924191
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41534585
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.41153243
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40264333
140Non-small cell lung cancer_Homo sapiens_hsa052230.39446532
141Type II diabetes mellitus_Homo sapiens_hsa049300.38786124
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38652941
143Apoptosis_Homo sapiens_hsa042100.38113605
144Salivary secretion_Homo sapiens_hsa049700.37821219
145Selenocompound metabolism_Homo sapiens_hsa004500.37734527
146ErbB signaling pathway_Homo sapiens_hsa040120.37581786
147Pancreatic cancer_Homo sapiens_hsa052120.36838245
148Ovarian steroidogenesis_Homo sapiens_hsa049130.36350185
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.36183946
150Gastric acid secretion_Homo sapiens_hsa049710.35796138
151Long-term depression_Homo sapiens_hsa047300.33624069
152Cholinergic synapse_Homo sapiens_hsa047250.33556230
153MAPK signaling pathway_Homo sapiens_hsa040100.33033600
154cAMP signaling pathway_Homo sapiens_hsa040240.33007514
155Mineral absorption_Homo sapiens_hsa049780.31423953
156Retinol metabolism_Homo sapiens_hsa008300.29993167
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29866490
158Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28530886
159Ras signaling pathway_Homo sapiens_hsa040140.28387536
160Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28352811
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28140702
162Neurotrophin signaling pathway_Homo sapiens_hsa047220.27660680
163Phospholipase D signaling pathway_Homo sapiens_hsa040720.27452563
164Glutathione metabolism_Homo sapiens_hsa004800.25953661
165Linoleic acid metabolism_Homo sapiens_hsa005910.25609674
166Oxytocin signaling pathway_Homo sapiens_hsa049210.24970666
167TNF signaling pathway_Homo sapiens_hsa046680.23948102
168Adipocytokine signaling pathway_Homo sapiens_hsa049200.23266824
169Dopaminergic synapse_Homo sapiens_hsa047280.23096727
170Insulin signaling pathway_Homo sapiens_hsa049100.19867205
171Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19080021
172Cysteine and methionine metabolism_Homo sapiens_hsa002700.17257823
173Lysosome_Homo sapiens_hsa041420.14436872
174Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14389981
175Taste transduction_Homo sapiens_hsa047420.14323789

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