CYP39A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)7.47741861
2L-phenylalanine catabolic process (GO:0006559)6.84129415
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.84129415
4L-phenylalanine metabolic process (GO:0006558)6.54084773
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.54084773
6oxidative demethylation (GO:0070989)5.84642279
7cysteine metabolic process (GO:0006534)5.78943430
8aromatic amino acid family catabolic process (GO:0009074)5.68632705
9intestinal cholesterol absorption (GO:0030299)5.60683250
10ethanol metabolic process (GO:0006067)5.54178487
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.36488045
12sulfur amino acid catabolic process (GO:0000098)5.33961961
13glyoxylate metabolic process (GO:0046487)5.27277815
14high-density lipoprotein particle remodeling (GO:0034375)5.26918639
15homocysteine metabolic process (GO:0050667)5.21578728
16negative regulation of fibrinolysis (GO:0051918)5.15801639
17phenylpropanoid metabolic process (GO:0009698)5.12010072
18* bile acid biosynthetic process (GO:0006699)4.92616843
19blood coagulation, intrinsic pathway (GO:0007597)4.83643523
20urea cycle (GO:0000050)4.81689252
21urea metabolic process (GO:0019627)4.81689252
22regulation of fibrinolysis (GO:0051917)4.81618269
23S-adenosylmethionine metabolic process (GO:0046500)4.79785484
24regulation of cholesterol esterification (GO:0010872)4.70651889
25protein carboxylation (GO:0018214)4.70650521
26peptidyl-glutamic acid carboxylation (GO:0017187)4.70650521
27indole-containing compound catabolic process (GO:0042436)4.65603511
28indolalkylamine catabolic process (GO:0046218)4.65603511
29tryptophan catabolic process (GO:0006569)4.65603511
30serine family amino acid biosynthetic process (GO:0009070)4.63210067
31cellular glucuronidation (GO:0052695)4.61554734
32serine family amino acid catabolic process (GO:0009071)4.61430316
33kynurenine metabolic process (GO:0070189)4.60960621
34xenobiotic catabolic process (GO:0042178)4.58838433
35tryptophan metabolic process (GO:0006568)4.55583061
36reverse cholesterol transport (GO:0043691)4.49655204
37regulation of triglyceride catabolic process (GO:0010896)4.39872784
38tyrosine metabolic process (GO:0006570)4.33150537
39nitrogen cycle metabolic process (GO:0071941)4.32986510
40regulation of protein activation cascade (GO:2000257)4.31421031
41plasma lipoprotein particle remodeling (GO:0034369)4.30401939
42protein-lipid complex remodeling (GO:0034368)4.30401939
43macromolecular complex remodeling (GO:0034367)4.30401939
44phospholipid efflux (GO:0033700)4.29554939
45serine family amino acid metabolic process (GO:0009069)4.27028432
46response to nitrosative stress (GO:0051409)4.26192485
47glycine metabolic process (GO:0006544)4.22468699
48alpha-linolenic acid metabolic process (GO:0036109)4.19900370
49uronic acid metabolic process (GO:0006063)4.19893139
50glucuronate metabolic process (GO:0019585)4.19893139
51alkaloid metabolic process (GO:0009820)4.18722452
52aromatic amino acid family metabolic process (GO:0009072)4.18613186
53complement activation, alternative pathway (GO:0006957)4.17690262
54amino-acid betaine metabolic process (GO:0006577)4.16926554
55cellular modified amino acid catabolic process (GO:0042219)4.16625924
56* bile acid metabolic process (GO:0008206)4.11714226
57alpha-amino acid catabolic process (GO:1901606)4.06571921
58benzene-containing compound metabolic process (GO:0042537)4.05410243
59protein activation cascade (GO:0072376)4.03187433
60regulation of complement activation (GO:0030449)3.96847678
61polyketide metabolic process (GO:0030638)3.94965436
62doxorubicin metabolic process (GO:0044598)3.94965436
63daunorubicin metabolic process (GO:0044597)3.94965436
64drug catabolic process (GO:0042737)3.89992685
65complement activation (GO:0006956)3.87047742
66cellular amino acid catabolic process (GO:0009063)3.86015367
67drug metabolic process (GO:0017144)3.84200836
68negative regulation of lipase activity (GO:0060192)3.82815766
69triglyceride homeostasis (GO:0070328)3.82034733
70acylglycerol homeostasis (GO:0055090)3.82034733
71fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.81797861
72ethanol oxidation (GO:0006069)3.80441504
73negative regulation of blood coagulation (GO:0030195)3.80170601
74negative regulation of hemostasis (GO:1900047)3.80170601
75lysine catabolic process (GO:0006554)3.79429788
76lysine metabolic process (GO:0006553)3.79429788
77opsonization (GO:0008228)3.78715805
78complement activation, classical pathway (GO:0006958)3.73688937
79coenzyme catabolic process (GO:0009109)3.66876860
80ketone body metabolic process (GO:1902224)3.66272703
81glutamate metabolic process (GO:0006536)3.64964085
82regulation of plasminogen activation (GO:0010755)3.64937584
83regulation of bile acid biosynthetic process (GO:0070857)3.64091455
84epoxygenase P450 pathway (GO:0019373)3.64061286
85negative regulation of cholesterol transport (GO:0032375)3.64002610
86negative regulation of sterol transport (GO:0032372)3.64002610
87negative regulation of complement activation (GO:0045916)3.63054838
88L-serine metabolic process (GO:0006563)3.60495307
89negative regulation of wound healing (GO:0061045)3.59727944
90fat-soluble vitamin biosynthetic process (GO:0042362)3.58240536
91cholesterol efflux (GO:0033344)3.58177908
92hormone catabolic process (GO:0042447)3.57360144
93aminoglycoside antibiotic metabolic process (GO:0030647)3.57242597
94primary alcohol metabolic process (GO:0034308)3.56436763
95fibrinolysis (GO:0042730)3.54795172
96plasma lipoprotein particle clearance (GO:0034381)3.54151160
97positive regulation of fatty acid beta-oxidation (GO:0032000)3.53056506
98diterpenoid biosynthetic process (GO:0016102)3.51884194
99exocrine pancreas development (GO:0031017)3.51284373
100negative regulation of coagulation (GO:0050819)3.51144751
101short-chain fatty acid metabolic process (GO:0046459)3.50238039
102aldehyde catabolic process (GO:0046185)3.49653700
103positive regulation of lipid catabolic process (GO:0050996)3.49515721
104* xenobiotic metabolic process (GO:0006805)3.49277424
105* carboxylic acid catabolic process (GO:0046395)3.48836988
106* organic acid catabolic process (GO:0016054)3.48836988
107positive regulation of triglyceride lipase activity (GO:0061365)3.47299182
108positive regulation of lipoprotein lipase activity (GO:0051006)3.47299182
109regulation of cholesterol biosynthetic process (GO:0045540)3.45260213
110regulation of humoral immune response (GO:0002920)3.44093642
111intestinal absorption (GO:0050892)3.43631495
112midgut development (GO:0007494)3.43175492
113low-density lipoprotein particle remodeling (GO:0034374)3.41099876
114primary alcohol catabolic process (GO:0034310)3.40095549
115cellular ketone body metabolic process (GO:0046950)3.39930235
116retinal metabolic process (GO:0042574)3.38962489
117exogenous drug catabolic process (GO:0042738)3.37430356
118arginine metabolic process (GO:0006525)3.37165848
119regulation of phospholipase A2 activity (GO:0032429)3.36893595
120negative regulation of protein activation cascade (GO:2000258)3.35953186
121flavonoid metabolic process (GO:0009812)3.33457277
122acute-phase response (GO:0006953)3.33288294
123regulation of cholesterol metabolic process (GO:0090181)3.32666154
124carnitine metabolic process (GO:0009437)3.31255937
125bile acid and bile salt transport (GO:0015721)3.30759035
126heme transport (GO:0015886)3.29004632
127plasma lipoprotein particle assembly (GO:0034377)3.25643022
128indolalkylamine metabolic process (GO:0006586)3.25180440
129imidazole-containing compound metabolic process (GO:0052803)3.24239290
130disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.19399980
131killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.19399980
132response to mercury ion (GO:0046689)3.18930866
133* monocarboxylic acid catabolic process (GO:0072329)3.15028588
134cellular aldehyde metabolic process (GO:0006081)3.14242797
135positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.05854128
136regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.98240919
137cofactor catabolic process (GO:0051187)2.96401314
138* steroid catabolic process (GO:0006706)2.95355272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.10606964
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.06904348
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.91764340
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.74335232
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.88183149
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.80097887
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.08210955
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.98029480
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.97908137
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.65364922
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.46971837
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41147200
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.41092831
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.38354620
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.15504036
16AR_21909140_ChIP-Seq_LNCAP_Human2.14345091
17CLOCK_20551151_ChIP-Seq_293T_Human2.14145310
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12297368
19GBX2_23144817_ChIP-Seq_PC3_Human2.02730083
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2734418
21FUS_26573619_Chip-Seq_HEK293_Human1.99979617
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.88664446
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75596994
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72519035
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65999546
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64222965
27* GATA4_25053715_ChIP-Seq_YYC3_Human1.63589400
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62130315
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61475622
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59138082
31P300_19829295_ChIP-Seq_ESCs_Human1.53699701
32* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49178226
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.48730550
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48548875
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45567910
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45147711
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41701752
38HTT_18923047_ChIP-ChIP_STHdh_Human1.40651830
39IGF1R_20145208_ChIP-Seq_DFB_Human1.39463561
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.37233062
41VDR_22108803_ChIP-Seq_LS180_Human1.36874147
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33421374
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.33285891
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30941319
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30868801
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.30056401
47HNFA_21074721_ChIP-Seq_CACO-2_Human1.30034501
48PHF8_20622853_ChIP-Seq_HELA_Human1.29468812
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28554095
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27848140
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.25458537
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23590566
53GATA1_22025678_ChIP-Seq_K562_Human1.23185018
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22311204
55CBP_20019798_ChIP-Seq_JUKART_Human1.20754738
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20754738
57AR_25329375_ChIP-Seq_VCAP_Human1.17705760
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17549880
59ER_23166858_ChIP-Seq_MCF-7_Human1.16680724
60PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.16452512
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.15715726
62NFYA_21822215_ChIP-Seq_K562_Human1.15656933
63GATA6_25053715_ChIP-Seq_YYC3_Human1.15115885
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.15007843
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14760876
66NFYB_21822215_ChIP-Seq_K562_Human1.13316333
67* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12660880
68* STAT3_23295773_ChIP-Seq_U87_Human1.12221795
69CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11802994
70ETV1_20927104_ChIP-Seq_GIST48_Human1.11513901
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11300128
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.10805214
73CBP_21632823_ChIP-Seq_H3396_Human1.10582230
74TBL1_22424771_ChIP-Seq_293T_Human1.10374481
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09280081
76* TCF4_22108803_ChIP-Seq_LS180_Human1.08342643
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.07428740
78RUNX2_22187159_ChIP-Seq_PCA_Human1.07419375
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07294020
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07294020
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06589591
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04914610
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04508973
84FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03776073
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03689521
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02714071
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02625108
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01829453
89NANOG_19829295_ChIP-Seq_ESCs_Human1.01182789
90SOX2_19829295_ChIP-Seq_ESCs_Human1.01182789
91CDX2_22108803_ChIP-Seq_LS180_Human1.00113702
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99064161
93* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98624087
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98019062
95SOX2_20726797_ChIP-Seq_SW620_Human0.97953335
96RBPJ_21746931_ChIP-Seq_IB4_Human0.97782546
97FOXA1_25552417_ChIP-Seq_VCAP_Human0.96444199
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96242223
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96228899
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96062260
101GATA6_21074721_ChIP-Seq_CACO-2_Human0.95819911
102* SMAD4_21741376_ChIP-Seq_EPCs_Human0.95780085
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95517672
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94539932
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93610919
106RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93244195
107CBX2_27304074_Chip-Seq_ESCs_Mouse0.91771336
108AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91116379
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89585878
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86479110
111* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85550567
112RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85291257
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81258913
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80365910
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78502465
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76159225
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74937542
118* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74662709
119* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74662709
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74441630
121GATA3_24758297_ChIP-Seq_MCF-7_Human0.74143426
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.73206837
123SOX2_18555785_ChIP-Seq_MESCs_Mouse0.70559386
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.70460352
125FOXM1_26456572_ChIP-Seq_MCF-7_Human0.69516531
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.67254674
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.67254674
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.66761065
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66128020
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.65526815
131CEBPB_22108803_ChIP-Seq_LS180_Human0.63599352
132* CHD1_26751641_Chip-Seq_LNCaP_Human0.63192238
133EGR1_19032775_ChIP-ChIP_M12_Human0.62565560
134TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.62344037
135KAP1_22055183_ChIP-Seq_ESCs_Mouse0.62175959
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.61276079
137SOX2_18692474_ChIP-Seq_MEFs_Mouse0.60010586
138SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.59798731
139TP53_18474530_ChIP-ChIP_U2OS_Human0.59571725
140PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.59034679
141FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.58945517
142CJUN_26792858_Chip-Seq_BT549_Human0.58696695
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.58690600
144ZNF263_19887448_ChIP-Seq_K562_Human0.57249635
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.55045054
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.54455396
147STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.53222457
148AHR_22903824_ChIP-Seq_MCF-7_Human0.52983622
149IRF1_19129219_ChIP-ChIP_H3396_Human0.52481187
150BCAT_22108803_ChIP-Seq_LS180_Human0.52398268
151TP63_23658742_ChIP-Seq_EP156T_Human0.52193500
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.51713499
153PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51565842
154AR_20517297_ChIP-Seq_VCAP_Human0.49824029
155ERG_20517297_ChIP-Seq_VCAP_Human0.49486919
156NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.48615459
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.47891351
158TAF15_26573619_Chip-Seq_HEK293_Human0.47451479
159KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.46719237
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.46668819
161KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.46039088
162TCF4_18268006_ChIP-ChIP_LS174T_Human0.45906052
163CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.45831818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.71823389
2MP0005365_abnormal_bile_salt6.09924559
3MP0005085_abnormal_gallbladder_physiolo5.62150621
4MP0005360_urolithiasis5.36298410
5MP0005083_abnormal_biliary_tract4.49764935
6MP0008875_abnormal_xenobiotic_pharmacok4.47477336
7MP0001666_abnormal_nutrient_absorption3.47487056
8MP0003252_abnormal_bile_duct3.27591587
9MP0003806_abnormal_nucleotide_metabolis2.74180477
10MP0010329_abnormal_lipoprotein_level2.59730441
11MP0005408_hypopigmentation2.46781938
12MP0003195_calcinosis2.41755381
13MP0005220_abnormal_exocrine_pancreas2.39601827
14MP0008789_abnormal_olfactory_epithelium2.15754487
15MP0000566_synostosis2.10374159
16MP0005332_abnormal_amino_acid1.99713435
17MP0003705_abnormal_hypodermis_morpholog1.95711546
18MP0009053_abnormal_anal_canal1.95014820
19MP0001986_abnormal_taste_sensitivity1.89434982
20MP0009840_abnormal_foam_cell1.80503441
21MP0003868_abnormal_feces_composition1.75175921
22MP0004019_abnormal_vitamin_homeostasis1.66981941
23MP0005499_abnormal_olfactory_system1.66775351
24MP0005394_taste/olfaction_phenotype1.66775351
25MP0010030_abnormal_orbit_morphology1.66133832
26MP0005451_abnormal_body_composition1.66116925
27MP0002118_abnormal_lipid_homeostasis1.59030333
28MP0002282_abnormal_trachea_morphology1.55270048
29MP0002138_abnormal_hepatobiliary_system1.53779864
30MP0003191_abnormal_cellular_cholesterol1.52864951
31MP0003878_abnormal_ear_physiology1.50647250
32MP0005377_hearing/vestibular/ear_phenot1.50647250
33MP0000609_abnormal_liver_physiology1.41956785
34MP0010368_abnormal_lymphatic_system1.39850521
35MP0002254_reproductive_system_inflammat1.39428770
36MP0005084_abnormal_gallbladder_morpholo1.39187572
37MP0003136_yellow_coat_color1.32422723
38MP0003186_abnormal_redox_activity1.30617993
39MP0009384_cardiac_valve_regurgitation1.27819284
40MP0005248_abnormal_Harderian_gland1.27688869
41MP0005410_abnormal_fertilization1.25767438
42MP0005319_abnormal_enzyme/_coenzyme1.20587587
43MP0002249_abnormal_larynx_morphology1.20121931
44MP0004782_abnormal_surfactant_physiolog1.16916865
45MP0002060_abnormal_skin_morphology1.16760858
46MP0003011_delayed_dark_adaptation1.16728203
47MP0000579_abnormal_nail_morphology1.16202396
48MP0001764_abnormal_homeostasis1.16116544
49MP0000678_abnormal_parathyroid_gland1.15326164
50MP0010386_abnormal_urinary_bladder1.09476432
51MP0002233_abnormal_nose_morphology1.05916963
52MP0009643_abnormal_urine_homeostasis1.05859014
53MP0002234_abnormal_pharynx_morphology1.05246194
54MP0002098_abnormal_vibrissa_morphology1.04170598
55MP0009379_abnormal_foot_pigmentation1.04149620
56MP0005670_abnormal_white_adipose1.02542542
57MP0001661_extended_life_span1.00452964
58MP0009697_abnormal_copulation0.99529721
59MP0001984_abnormal_olfaction0.99058308
60MP0000647_abnormal_sebaceous_gland0.95671392
61MP0002653_abnormal_ependyma_morphology0.95467564
62MP0000598_abnormal_liver_morphology0.87158315
63MP0002796_impaired_skin_barrier0.87043624
64MP0005647_abnormal_sex_gland0.85058148
65MP0001485_abnormal_pinna_reflex0.82533496
66MP0001849_ear_inflammation0.82486932
67MP0004885_abnormal_endolymph0.81780635
68MP0003942_abnormal_urinary_system0.81071299
69MP0003315_abnormal_perineum_morphology0.78922757
70MP0005275_abnormal_skin_tensile0.78695472
71MP0002277_abnormal_respiratory_mucosa0.78440333
72MP0002132_abnormal_respiratory_system0.78111645
73MP0001346_abnormal_lacrimal_gland0.77971202
74MP0002090_abnormal_vision0.76277436
75MP0000569_abnormal_digit_pigmentation0.75834954
76MP0004264_abnormal_extraembryonic_tissu0.72457275
77MP0000383_abnormal_hair_follicle0.72102224
78MP0003453_abnormal_keratinocyte_physiol0.72031729
79MP0001324_abnormal_eye_pigmentation0.70452321
80MP0002638_abnormal_pupillary_reflex0.70405626
81MP0002009_preneoplasia0.68451599
82MP0005187_abnormal_penis_morphology0.68425332
83MP0005395_other_phenotype0.67961560
84MP0004381_abnormal_hair_follicle0.67773115
85MP0002697_abnormal_eye_size0.66546868
86MP0000613_abnormal_salivary_gland0.65241420
87MP0003941_abnormal_skin_development0.63983567
88MP0003698_abnormal_male_reproductive0.63972339
89MP0001177_atelectasis0.63862320
90MP0005197_abnormal_uvea_morphology0.63043371
91MP0009765_abnormal_xenobiotic_induced0.63017397
92MP0006035_abnormal_mitochondrial_morpho0.61730182
93MP0003937_abnormal_limbs/digits/tail_de0.61076319
94MP0005584_abnormal_enzyme/coenzyme_acti0.60920803
95MP0005551_abnormal_eye_electrophysiolog0.59863904
96MP0001243_abnormal_dermal_layer0.59499674
97MP0000467_abnormal_esophagus_morphology0.59469341
98MP0002168_other_aberrant_phenotype0.59384052
99MP0009780_abnormal_chondrocyte_physiolo0.59161165
100MP0001944_abnormal_pancreas_morphology0.58996690
101MP0004742_abnormal_vestibular_system0.58101665
102MP0000762_abnormal_tongue_morphology0.57829498
103MP0004272_abnormal_basement_membrane0.57814866
104MP0001340_abnormal_eyelid_morphology0.57278301
105MP0003115_abnormal_respiratory_system0.56730383
106MP0006292_abnormal_olfactory_placode0.56020688
107MP0001293_anophthalmia0.55980885
108MP0005023_abnormal_wound_healing0.55419205
109MP0005376_homeostasis/metabolism_phenot0.54709311
110MP0008438_abnormal_cutaneous_collagen0.53679194
111MP0005253_abnormal_eye_physiology0.53545762
112MP0003938_abnormal_ear_development0.53544797
113MP0005636_abnormal_mineral_homeostasis0.52726862
114MP0001929_abnormal_gametogenesis0.52327197
115MP0009763_increased_sensitivity_to0.52109381
116MP0009642_abnormal_blood_homeostasis0.51970810
117MP0002928_abnormal_bile_duct0.51763300
118MP0010678_abnormal_skin_adnexa0.51408787
119MP0000639_abnormal_adrenal_gland0.51331224
120MP0003122_maternal_imprinting0.51124217
121MP0009764_decreased_sensitivity_to0.50960155
122MP0002822_catalepsy0.50412403
123MP0000049_abnormal_middle_ear0.49579624
124MP0002938_white_spotting0.49544648
125MP0003718_maternal_effect0.49393461
126MP0001756_abnormal_urination0.49214332
127MP0000427_abnormal_hair_cycle0.48236877
128MP0003638_abnormal_response/metabolism_0.48043156
129MP0009672_abnormal_birth_weight0.47570357
130MP0004133_heterotaxia0.45979282
131MP0002111_abnormal_tail_morphology0.45976448
132MP0003890_abnormal_embryonic-extraembry0.45931566
133MP0000377_abnormal_hair_follicle0.45887005
134MP0004142_abnormal_muscle_tone0.45741823
135MP0002876_abnormal_thyroid_physiology0.45415748
136MP0003283_abnormal_digestive_organ0.45404310
137MP0001216_abnormal_epidermal_layer0.45164671
138MP0000026_abnormal_inner_ear0.44523448
139MP0001299_abnormal_eye_distance/0.43569008
140MP0002078_abnormal_glucose_homeostasis0.41096014
141MP0000534_abnormal_ureter_morphology0.41011604
142MP0006072_abnormal_retinal_apoptosis0.39580979
143MP0001286_abnormal_eye_development0.39183960
144MP0005171_absent_coat_pigmentation0.38115169

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.71646452
2Deep venous thrombosis (HP:0002625)6.57410368
3Intrahepatic cholestasis (HP:0001406)6.50461941
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.79413676
5Prolonged partial thromboplastin time (HP:0003645)5.42268594
6Xanthomatosis (HP:0000991)5.30507483
7Hypobetalipoproteinemia (HP:0003563)5.01701800
8Abnormality of methionine metabolism (HP:0010901)4.63480158
9Fat malabsorption (HP:0002630)4.41197782
10Abnormality of sulfur amino acid metabolism (HP:0004339)4.30473945
11Hyperlipoproteinemia (HP:0010980)4.26263070
12Abnormality of aspartate family amino acid metabolism (HP:0010899)4.23640817
13Abnormality of the common coagulation pathway (HP:0010990)4.19797300
14Systemic lupus erythematosus (HP:0002725)4.16467301
15Hyperglycinemia (HP:0002154)4.16459374
16Hyperglycinuria (HP:0003108)4.04677944
17Hypolipoproteinemia (HP:0010981)4.04402866
18Ketosis (HP:0001946)4.02991667
19Hyperammonemia (HP:0001987)3.96937320
20Complement deficiency (HP:0004431)3.89739107
21Hypoalphalipoproteinemia (HP:0003233)3.89481543
22Abnormality of the intrinsic pathway (HP:0010989)3.80891613
23Steatorrhea (HP:0002570)3.79836962
24Abnormality of serine family amino acid metabolism (HP:0010894)3.73341247
25Abnormality of glycine metabolism (HP:0010895)3.73341247
26Hypoglycemic coma (HP:0001325)3.68635558
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.65128900
28Epidermoid cyst (HP:0200040)3.63084456
29Joint hemorrhage (HP:0005261)3.62299754
30Chronic hepatic failure (HP:0100626)3.60797814
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.57014422
32Nephritis (HP:0000123)3.50864186
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.42460255
34Ketoacidosis (HP:0001993)3.26793876
35Conjugated hyperbilirubinemia (HP:0002908)3.24743626
36Osteomalacia (HP:0002749)3.23581662
37Gout (HP:0001997)3.19021472
38Abnormality of fatty-acid metabolism (HP:0004359)3.12962728
39Hepatocellular carcinoma (HP:0001402)3.07367600
40Abnormality of pyrimidine metabolism (HP:0004353)3.03592716
41Hyperbilirubinemia (HP:0002904)2.86611641
42Hyperphosphaturia (HP:0003109)2.84677897
43Abnormality of serum amino acid levels (HP:0003112)2.83707872
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.83341913
45Biconcave vertebral bodies (HP:0004586)2.81129860
46Hypercholesterolemia (HP:0003124)2.80400848
47Abnormal respiratory motile cilium physiology (HP:0012261)2.78476448
48Abnormality of nucleobase metabolism (HP:0010932)2.76490291
49Abnormality of complement system (HP:0005339)2.73828799
50Rickets (HP:0002748)2.67608919
51Esophageal varix (HP:0002040)2.63786249
52Abnormality of purine metabolism (HP:0004352)2.62939079
53Opisthotonus (HP:0002179)2.54695842
54Rhinitis (HP:0012384)2.54026660
55Hyperglycemia (HP:0003074)2.47427616
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45600219
57Dicarboxylic aciduria (HP:0003215)2.45600219
58Enlarged kidneys (HP:0000105)2.44456486
59Abnormal ciliary motility (HP:0012262)2.44341365
60Metabolic acidosis (HP:0001942)2.42405338
61Abnormal hemoglobin (HP:0011902)2.40261546
62Spontaneous abortion (HP:0005268)2.38819988
63Lip pit (HP:0100267)2.35029003
64Myocardial infarction (HP:0001658)2.34227341
65Abnormality of vitamin metabolism (HP:0100508)2.34053762
66Right ventricular cardiomyopathy (HP:0011663)2.30445013
67Alkalosis (HP:0001948)2.28941909
68Lethargy (HP:0001254)2.27770955
69Reduced antithrombin III activity (HP:0001976)2.25904741
70Pancreatitis (HP:0001733)2.25481769
71True hermaphroditism (HP:0010459)2.24711266
72Cerebral edema (HP:0002181)2.23986361
73Vascular calcification (HP:0004934)2.20080928
74Renal cortical cysts (HP:0000803)2.17737574
75Tubulointerstitial fibrosis (HP:0005576)2.16923438
76Hypoglycemic seizures (HP:0002173)2.16802571
77Recurrent gram-negative bacterial infections (HP:0005420)2.14678998
78Abnormal respiratory motile cilium morphology (HP:0005938)2.14551825
79Abnormal respiratory epithelium morphology (HP:0012253)2.14551825
80Abnormal urine phosphate concentration (HP:0012599)2.13971993
81Delayed CNS myelination (HP:0002188)2.11630395
82Abnormal biliary tract physiology (HP:0012439)2.09009370
83Bile duct proliferation (HP:0001408)2.09009370
84Generalized aminoaciduria (HP:0002909)2.07976650
85Exocrine pancreatic insufficiency (HP:0001738)2.06853692
86Cardiovascular calcification (HP:0011915)2.05134542
87Tubulointerstitial nephritis (HP:0001970)2.04480505
88Arthropathy (HP:0003040)2.03499294
89Amyloidosis (HP:0011034)2.02869851
90Late onset (HP:0003584)2.00657575
91Neonatal death (HP:0003811)1.97349185
92Chorioretinal atrophy (HP:0000533)1.95181586
93Chronic bronchitis (HP:0004469)1.94310055
94Mitral stenosis (HP:0001718)1.92714221
95Abnormality of the renal cortex (HP:0011035)1.91002068
96Increased purine levels (HP:0004368)1.90281274
97Hyperuricemia (HP:0002149)1.90281274
98Abnormality of the pancreatic islet cells (HP:0006476)1.88717889
99Abnormality of endocrine pancreas physiology (HP:0012093)1.88717889
100Pancreatic islet-cell hyperplasia (HP:0004510)1.88229933
101Spastic diplegia (HP:0001264)1.84749193
102Nephronophthisis (HP:0000090)1.84376583
103Skin nodule (HP:0200036)1.84330293
104Vomiting (HP:0002013)1.84186457
105Abnormality of urine glucose concentration (HP:0011016)1.82496626
106Glycosuria (HP:0003076)1.82496626
107Hepatoblastoma (HP:0002884)1.80705648
108Tubulointerstitial abnormality (HP:0001969)1.80611838
109Occipital encephalocele (HP:0002085)1.79891718
110Glomerulonephritis (HP:0000099)1.79533942
111Hyperinsulinemic hypoglycemia (HP:0000825)1.79080524
112Bifid scrotum (HP:0000048)1.77967694
113Abnormal gallbladder morphology (HP:0012437)1.77411343
114Dynein arm defect of respiratory motile cilia (HP:0012255)1.76973205
115Absent/shortened dynein arms (HP:0200106)1.76973205
116Hypophosphatemic rickets (HP:0004912)1.76742554
117Irritability (HP:0000737)1.74821674
118Neonatal onset (HP:0003623)1.74173671
119Glomerulosclerosis (HP:0000096)1.71787993
120Malnutrition (HP:0004395)1.71434822
121Neoplasm of the liver (HP:0002896)1.71364611
122Proximal tubulopathy (HP:0000114)1.69082267
123Abnormality of cochlea (HP:0000375)1.68023906
124Pancreatic fibrosis (HP:0100732)1.67968769
125Hypothermia (HP:0002045)1.67945097
126Acute encephalopathy (HP:0006846)1.65345842
127Fair hair (HP:0002286)1.65049355
128Elevated hepatic transaminases (HP:0002910)1.65027129
129Azoospermia (HP:0000027)1.64550519
130Male pseudohermaphroditism (HP:0000037)1.64197248
131Prenatal maternal abnormality (HP:0002686)1.64114036
132Absent eyelashes (HP:0000561)1.63267893
133Abnormal cartilage morphology (HP:0002763)1.62391236
134Stage 5 chronic kidney disease (HP:0003774)1.58241030
135Gonadotropin excess (HP:0000837)1.53896609
136Pancreatic cysts (HP:0001737)1.53249715
137Abnormality of the renal medulla (HP:0100957)1.49054507
138Molar tooth sign on MRI (HP:0002419)1.44892331
139Abnormality of midbrain morphology (HP:0002418)1.44892331
140Tubular atrophy (HP:0000092)1.42905149
141Cystic liver disease (HP:0006706)1.40849076
142Abnormal sex determination (HP:0012244)1.39936521
143Sex reversal (HP:0012245)1.39936521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.99026212
2BCKDK5.51360077
3PNCK4.56970800
4ERN13.27213871
5NUAK12.88978211
6MST1R2.71654567
7SIK12.44242131
8FGFR42.14078563
9STK38L2.08149172
10FRK2.04345606
11BUB12.02462282
12CCNB11.99817161
13NEK11.92125137
14SGK21.82200555
15WNK31.73250425
16MAP3K31.72134442
17VRK11.71063595
18INSRR1.69048049
19PLK21.63944203
20SGK2231.62765363
21SGK4941.62765363
22MAP2K21.59814729
23STK31.57770117
24MAP2K61.54593887
25EPHA41.53791993
26WEE11.51342088
27BRSK21.40787229
28LMTK21.40133127
29STK161.39644206
30CAMK1G1.38371330
31SGK31.30245457
32MAP3K41.29647036
33ERBB31.27724556
34VRK21.26285719
35PRKCG1.25878006
36PIK3CG1.24847109
37PKN21.24540325
38EPHB21.23138107
39TSSK61.22084282
40MAP3K21.18628649
41FGFR21.16359667
42MAPK151.13953827
43CAMKK21.10567638
44TRIB31.09573941
45TGFBR11.08343916
46EPHA31.05432581
47YES11.05268368
48STK241.04900217
49NEK91.03836706
50PTK61.03208973
51ERBB41.01772128
52CDK61.01088434
53TAOK20.98542078
54CASK0.97581724
55AKT30.96698946
56PRKCE0.96425655
57MET0.96241743
58PASK0.93796242
59LRRK20.93142181
60PLK40.93072069
61ABL20.88101033
62DYRK1B0.87803356
63MAP3K70.87647522
64MAP2K40.86787751
65TESK10.86778090
66CDK30.86263071
67PLK30.85814504
68TAOK30.85744627
69EIF2AK30.84376516
70FGFR30.84050744
71ERBB20.83230641
72BMPR20.82466927
73MKNK10.80595793
74BRSK10.79877251
75MAPKAPK30.79721297
76BRD40.78135380
77GRK10.76144812
78MAPK110.75862554
79LATS20.74602515
80TNIK0.72597620
81DYRK30.72525269
82MAP2K10.72199064
83STK380.71434787
84MYLK0.70403290
85MAP3K120.70145855
86BMPR1B0.69530399
87TRPM70.68349404
88PRKG10.63489107
89STK100.62794208
90BRAF0.61871527
91IRAK10.60308915
92GSK3A0.59936446
93MST40.59288368
94PIK3CA0.58509851
95MAP3K140.58405349
96FLT30.57697042
97DYRK1A0.56777967
98FER0.56573491
99SRPK10.56023145
100TAF10.54123969
101AURKB0.53234487
102TGFBR20.52673151
103PRPF4B0.52670142
104FGFR10.52035654
105PRKACA0.51788302
106CSNK1G10.51211893
107PINK10.50040706
108MAP4K20.49346032
109CSNK1A10.48295930
110CHUK0.47927378
111RPS6KB20.47697352
112PBK0.46096043
113NTRK20.44043568
114PDK30.43336442
115PDK40.43336442
116PDK20.42579735
117STK390.42166697
118CDK80.41957477
119PTK20.41904947
120DYRK20.41006481
121DAPK20.40959230
122MKNK20.40668474
123OBSCN0.40278042
124STK40.39808925
125ROCK20.39334323
126IGF1R0.38742225
127PRKCZ0.37947106
128EPHA20.37091181
129ZAK0.36342474
130MAPK30.35236025
131TYK20.35210806
132PRKAA20.34454710
133MAPK70.33968575
134RPS6KA40.33613293
135NLK0.31824749
136ROCK10.30543758
137TTK0.29714752
138PLK10.29470930
139PRKAA10.29454869
140PAK30.28176485
141CSNK2A10.27650415
142JAK20.27092522
143BCR0.26882588
144RPS6KL10.26880264
145RPS6KC10.26880264
146PRKACG0.26464486
147PKN10.26314386

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001203.74772562
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41511341
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.01104968
4Nitrogen metabolism_Homo sapiens_hsa009102.77703235
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71783771
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67866380
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.67504884
8Chemical carcinogenesis_Homo sapiens_hsa052042.55195847
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50267408
10Fatty acid degradation_Homo sapiens_hsa000712.49686743
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42118504
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38194935
13Tryptophan metabolism_Homo sapiens_hsa003802.35861315
14Arginine biosynthesis_Homo sapiens_hsa002202.32218833
15Complement and coagulation cascades_Homo sapiens_hsa046102.31084588
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.28266183
17Selenocompound metabolism_Homo sapiens_hsa004502.03954483
18Retinol metabolism_Homo sapiens_hsa008302.02306265
19Propanoate metabolism_Homo sapiens_hsa006402.00096875
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.99731008
21Peroxisome_Homo sapiens_hsa041461.86815019
22Butanoate metabolism_Homo sapiens_hsa006501.86423423
23Fat digestion and absorption_Homo sapiens_hsa049751.84167510
24Histidine metabolism_Homo sapiens_hsa003401.82207428
25Caffeine metabolism_Homo sapiens_hsa002321.73407705
26Sulfur metabolism_Homo sapiens_hsa009201.72875800
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70418981
28Folate biosynthesis_Homo sapiens_hsa007901.70282103
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.69617462
30beta-Alanine metabolism_Homo sapiens_hsa004101.67486828
31Phenylalanine metabolism_Homo sapiens_hsa003601.66414710
32Fatty acid metabolism_Homo sapiens_hsa012121.64324727
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.60417206
34PPAR signaling pathway_Homo sapiens_hsa033201.59564933
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.51426217
36Steroid biosynthesis_Homo sapiens_hsa001001.50948627
37Tyrosine metabolism_Homo sapiens_hsa003501.48612644
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46995159
39Starch and sucrose metabolism_Homo sapiens_hsa005001.43083594
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42177762
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42075643
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34053704
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.30959800
44One carbon pool by folate_Homo sapiens_hsa006701.30709118
45Glutathione metabolism_Homo sapiens_hsa004801.30195375
46Sulfur relay system_Homo sapiens_hsa041221.30002027
47Fatty acid elongation_Homo sapiens_hsa000621.24808624
48Staphylococcus aureus infection_Homo sapiens_hsa051501.24086729
49Pyruvate metabolism_Homo sapiens_hsa006201.17950052
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17491805
51Biosynthesis of amino acids_Homo sapiens_hsa012301.10114532
52Bile secretion_Homo sapiens_hsa049761.07632575
53Arginine and proline metabolism_Homo sapiens_hsa003301.00044855
54Carbon metabolism_Homo sapiens_hsa012000.91203706
55Vitamin digestion and absorption_Homo sapiens_hsa049770.90869105
56ABC transporters_Homo sapiens_hsa020100.89855536
57Glycerolipid metabolism_Homo sapiens_hsa005610.86160769
58Pancreatic secretion_Homo sapiens_hsa049720.80398579
59Protein digestion and absorption_Homo sapiens_hsa049740.75951542
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71715864
61Lysine degradation_Homo sapiens_hsa003100.70615831
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68855862
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61934971
64Linoleic acid metabolism_Homo sapiens_hsa005910.53975207
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49841391
66Metabolic pathways_Homo sapiens_hsa011000.47908087
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47153425
68Pentose phosphate pathway_Homo sapiens_hsa000300.39944457
69Fatty acid biosynthesis_Homo sapiens_hsa000610.37977856
70Vitamin B6 metabolism_Homo sapiens_hsa007500.31769273
71Oxidative phosphorylation_Homo sapiens_hsa001900.31523218
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31229958
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29481156
74Arachidonic acid metabolism_Homo sapiens_hsa005900.23492616
75Parkinsons disease_Homo sapiens_hsa050120.22708750
76Galactose metabolism_Homo sapiens_hsa000520.21649619
77Circadian rhythm_Homo sapiens_hsa047100.19645839
78Insulin resistance_Homo sapiens_hsa049310.16312613
79Huntingtons disease_Homo sapiens_hsa050160.15779060
80Serotonergic synapse_Homo sapiens_hsa047260.15727179
81Mineral absorption_Homo sapiens_hsa049780.12984987
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12332291
83Fructose and mannose metabolism_Homo sapiens_hsa000510.11823553
84Ribosome_Homo sapiens_hsa030100.08743197
85Protein export_Homo sapiens_hsa030600.06532113
86Alzheimers disease_Homo sapiens_hsa050100.01481876
87Hedgehog signaling pathway_Homo sapiens_hsa043400.01296528
88Renin-angiotensin system_Homo sapiens_hsa046140.01273428
89Prion diseases_Homo sapiens_hsa050200.01174241
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00627683
91p53 signaling pathway_Homo sapiens_hsa041150.00397782
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00378567
93TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1106296
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0986096
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0977996
96Sphingolipid metabolism_Homo sapiens_hsa00600-0.0952352
97N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0921586
98Base excision repair_Homo sapiens_hsa03410-0.0919008
99Tight junction_Homo sapiens_hsa04530-0.0867849
100Small cell lung cancer_Homo sapiens_hsa05222-0.0843750
101Pertussis_Homo sapiens_hsa05133-0.0841947
102AMPK signaling pathway_Homo sapiens_hsa04152-0.0793155
103ECM-receptor interaction_Homo sapiens_hsa04512-0.0735046
104Mismatch repair_Homo sapiens_hsa03430-0.0691073
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0682694
106Basal cell carcinoma_Homo sapiens_hsa05217-0.0585212
107Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0583671
108Adherens junction_Homo sapiens_hsa04520-0.0562452
109Ether lipid metabolism_Homo sapiens_hsa00565-0.0491421
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0462545
111Glucagon signaling pathway_Homo sapiens_hsa04922-0.0413659
112Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0354864
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0328454
114Cardiac muscle contraction_Homo sapiens_hsa04260-0.0308383
115Thyroid cancer_Homo sapiens_hsa05216-0.0214130
116Bladder cancer_Homo sapiens_hsa05219-0.0132544
117Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0097159

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