CYP3A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glyoxylate metabolic process (GO:0046487)9.25389708
2regulation of fibrinolysis (GO:0051917)8.32177856
3negative regulation of fibrinolysis (GO:0051918)8.10811656
4complement activation, alternative pathway (GO:0006957)7.64250001
5negative regulation of cholesterol transport (GO:0032375)7.60009966
6negative regulation of sterol transport (GO:0032372)7.60009966
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.51075455
8L-phenylalanine catabolic process (GO:0006559)7.51075455
9regulation of protein activation cascade (GO:2000257)7.38558388
10drug catabolic process (GO:0042737)7.35053233
11regulation of complement activation (GO:0030449)6.92582082
12protein carboxylation (GO:0018214)6.89408004
13peptidyl-glutamic acid carboxylation (GO:0017187)6.89408004
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.88629526
15L-phenylalanine metabolic process (GO:0006558)6.88629526
16epoxygenase P450 pathway (GO:0019373)6.88554810
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.78510490
18urea metabolic process (GO:0019627)6.67428446
19exogenous drug catabolic process (GO:0042738)6.59067220
20fibrinolysis (GO:0042730)6.48594385
21phospholipid efflux (GO:0033700)6.44733558
22urea cycle (GO:0000050)6.32929494
23serine family amino acid catabolic process (GO:0009071)6.23995969
24omega-hydroxylase P450 pathway (GO:0097267)6.13692093
25regulation of triglyceride catabolic process (GO:0010896)6.10466043
26nitrogen cycle metabolic process (GO:0071941)6.04930239
27blood coagulation, intrinsic pathway (GO:0007597)5.99617312
28regulation of plasminogen activation (GO:0010755)5.74191117
29regulation of cholesterol esterification (GO:0010872)5.71783002
30aromatic amino acid family catabolic process (GO:0009074)5.31746832
31protein-lipid complex remodeling (GO:0034368)5.29440524
32macromolecular complex remodeling (GO:0034367)5.29440524
33plasma lipoprotein particle remodeling (GO:0034369)5.29440524
34positive regulation of triglyceride lipase activity (GO:0061365)5.25830032
35positive regulation of lipoprotein lipase activity (GO:0051006)5.25830032
36drug metabolic process (GO:0017144)5.14093990
37cholesterol efflux (GO:0033344)5.08577662
38glycine metabolic process (GO:0006544)5.08391812
39high-density lipoprotein particle remodeling (GO:0034375)5.07698593
40phenylpropanoid metabolic process (GO:0009698)5.04204812
41cellular glucuronidation (GO:0052695)5.03505162
42negative regulation of hemostasis (GO:1900047)4.85808040
43negative regulation of blood coagulation (GO:0030195)4.85808040
44oxidative demethylation (GO:0070989)4.85272051
45acylglycerol homeostasis (GO:0055090)4.83225491
46triglyceride homeostasis (GO:0070328)4.83225491
47uronic acid metabolic process (GO:0006063)4.81045463
48glucuronate metabolic process (GO:0019585)4.81045463
49reverse cholesterol transport (GO:0043691)4.80943188
50protein activation cascade (GO:0072376)4.77116574
51bile acid biosynthetic process (GO:0006699)4.70948702
52regulation of lipoprotein particle clearance (GO:0010984)4.70710600
53plasma lipoprotein particle clearance (GO:0034381)4.53350289
54positive regulation of blood coagulation (GO:0030194)4.52213489
55positive regulation of hemostasis (GO:1900048)4.52213489
56very-low-density lipoprotein particle assembly (GO:0034379)4.47688279
57bile acid and bile salt transport (GO:0015721)4.44144290
58bile acid metabolic process (GO:0008206)4.43631720
59negative regulation of coagulation (GO:0050819)4.43114454
60intestinal cholesterol absorption (GO:0030299)4.41015847
61serine family amino acid metabolic process (GO:0009069)4.37104957
62complement activation, classical pathway (GO:0006958)4.35106684
63complement activation (GO:0006956)4.32471025
64regulation of humoral immune response (GO:0002920)4.31593544
65negative regulation of wound healing (GO:0061045)4.31259987
66negative regulation of lipase activity (GO:0060192)4.30908137
67ethanol oxidation (GO:0006069)4.24533785
68proline metabolic process (GO:0006560)4.16732246
69positive regulation of coagulation (GO:0050820)4.16082015
70negative regulation of protein activation cascade (GO:2000258)4.13160559
71positive regulation of fatty acid biosynthetic process (GO:0045723)4.06313243
72serine family amino acid biosynthetic process (GO:0009070)4.03976336
73arginine metabolic process (GO:0006525)4.01991409
74acute-phase response (GO:0006953)4.01643598
75plasma lipoprotein particle organization (GO:0071827)4.00632947
76plasma lipoprotein particle assembly (GO:0034377)3.96634845
77alpha-amino acid catabolic process (GO:1901606)3.95873569
78tyrosine metabolic process (GO:0006570)3.92368773
79flavonoid metabolic process (GO:0009812)3.90391179
80alkaloid metabolic process (GO:0009820)3.87713160
81imidazole-containing compound metabolic process (GO:0052803)3.83960443
82negative regulation of lipid transport (GO:0032369)3.81502809
83hormone catabolic process (GO:0042447)3.80949413
84positive regulation of lipid catabolic process (GO:0050996)3.76903267
85protein-lipid complex subunit organization (GO:0071825)3.75471677
86glutamate metabolic process (GO:0006536)3.74824418
87aldehyde catabolic process (GO:0046185)3.70794876
88cysteine metabolic process (GO:0006534)3.68397438
89regulation of apoptotic cell clearance (GO:2000425)3.67125073
90heme transport (GO:0015886)3.62718197
91arginine catabolic process (GO:0006527)3.62549258
92low-density lipoprotein particle remodeling (GO:0034374)3.61481686
93negative regulation of complement activation (GO:0045916)3.59518950
94drug transmembrane transport (GO:0006855)3.56696313
95cellular ketone body metabolic process (GO:0046950)3.56106605
96sulfur amino acid catabolic process (GO:0000098)3.54244020
97L-serine metabolic process (GO:0006563)3.53337870
98negative regulation of fatty acid biosynthetic process (GO:0045717)3.52767637
99protein-lipid complex assembly (GO:0065005)3.50950083
100ethanol metabolic process (GO:0006067)3.48522509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.34587246
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.86995880
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.04828402
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.58810772
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.91394167
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.50290442
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.15336264
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06604594
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.85815658
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.34367696
11FOXA2_19822575_ChIP-Seq_HepG2_Human2.33924984
12* HNF4A_19822575_ChIP-Seq_HepG2_Human2.25701575
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00923756
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2676563
15ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85077109
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83946209
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67396461
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60824827
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55007656
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46564533
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.45026819
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38216938
23HTT_18923047_ChIP-ChIP_STHdh_Human1.37698549
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.23617574
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15643433
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13100945
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12130119
28GATA4_25053715_ChIP-Seq_YYC3_Human1.01729053
29LXR_22292898_ChIP-Seq_THP-1_Human1.01138310
30AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98341259
31ESR2_21235772_ChIP-Seq_MCF-7_Human0.97068710
32PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96789847
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89047808
34GATA1_22025678_ChIP-Seq_K562_Human0.88891246
35CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87514926
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87472430
37IRF8_22096565_ChIP-ChIP_GC-B_Human0.86997310
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86240736
39GATA6_25053715_ChIP-Seq_YYC3_Human0.85126640
40CDX2_20551321_ChIP-Seq_CACO-2_Human0.84658161
41TRIM28_21343339_ChIP-Seq_HEK293_Human0.83244654
42KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83211716
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81228974
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80501209
45CEBPB_22108803_ChIP-Seq_LS180_Human0.80370800
46SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80337975
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78135197
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75409450
49SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74814419
50HNFA_21074721_ChIP-Seq_CACO-2_Human0.74555979
51TCF4_18268006_ChIP-ChIP_LS174T_Human0.74234334
52* SOX2_20726797_ChIP-Seq_SW620_Human0.74004527
53GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73816289
54CTCF_27219007_Chip-Seq_Bcells_Human0.70197508
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.70055455
56GATA6_21074721_ChIP-Seq_CACO-2_Human0.69133205
57SOX2_21211035_ChIP-Seq_LN229_Human0.68937839
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.68647001
59EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.68525348
60ERG_21242973_ChIP-ChIP_JURKAT_Human0.68483166
61NFYA_21822215_ChIP-Seq_K562_Human0.68257889
62SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67707798
63POU5F1_16518401_ChIP-PET_MESCs_Mouse0.67261894
64SA1_27219007_Chip-Seq_Bcells_Human0.67226578
65PHF8_20622853_ChIP-Seq_HELA_Human0.66111016
66JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.65678984
67MYC_19915707_ChIP-ChIP_AK7_Human0.65042690
68NFE2_27457419_Chip-Seq_LIVER_Mouse0.65002402
69P53_21459846_ChIP-Seq_SAOS-2_Human0.64466578
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64443068
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64297746
72FOXA1_25552417_ChIP-Seq_VCAP_Human0.63670127
73GATA1_19941827_ChIP-Seq_MEL_Mouse0.63277107
74ETV2_25802403_ChIP-Seq_MESCs_Mouse0.63000175
75IRF1_19129219_ChIP-ChIP_H3396_Human0.62946118
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.62557294
77CBX2_22325352_ChIP-Seq_293T-Rex_Human0.62547821
78AR_20517297_ChIP-Seq_VCAP_Human0.62263943
79ELF1_20517297_ChIP-Seq_JURKAT_Human0.60931237
80E2F1_20622854_ChIP-Seq_HELA_Human0.60583062
81RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59877341
82SMC4_20622854_ChIP-Seq_HELA_Human0.59660694
83DNAJC2_21179169_ChIP-ChIP_NT2_Human0.58131898
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56959676
85ETV1_20927104_ChIP-Seq_GIST48_Human0.56828582
86RARG_19884340_ChIP-ChIP_MEFs_Mouse0.56306827
87RARA_24833708_ChIP-Seq_LIVER_Mouse0.56205991
88RAC3_21632823_ChIP-Seq_H3396_Human0.55345427
89CTCF_20526341_ChIP-Seq_ESCs_Human0.55338204
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.55183232
91CLOCK_20551151_ChIP-Seq_293T_Human0.54912229
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.54775296
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.54452846
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.53097176
95STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.51566507
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.51472257
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.51003149
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.50888194
99SPI1_20517297_ChIP-Seq_HL60_Human0.50154548
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49525860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.63915361
2MP0005360_urolithiasis7.26569091
3MP0005085_abnormal_gallbladder_physiolo5.94793777
4MP0003195_calcinosis5.84283036
5MP0002138_abnormal_hepatobiliary_system5.44509046
6MP0005365_abnormal_bile_salt5.10993309
7MP0008875_abnormal_xenobiotic_pharmacok3.89864933
8MP0003252_abnormal_bile_duct3.60189894
9MP0003868_abnormal_feces_composition3.33394361
10MP0001666_abnormal_nutrient_absorption3.18785563
11MP0010329_abnormal_lipoprotein_level2.92614796
12MP0009840_abnormal_foam_cell2.77675767
13MP0009697_abnormal_copulation2.76884764
14MP0002876_abnormal_thyroid_physiology2.64065633
15MP0005332_abnormal_amino_acid2.51466640
16MP0003806_abnormal_nucleotide_metabolis1.84432984
17MP0001764_abnormal_homeostasis1.76783904
18MP0000609_abnormal_liver_physiology1.71569860
19MP0002118_abnormal_lipid_homeostasis1.65046013
20MP0005083_abnormal_biliary_tract1.59621895
21MP0010368_abnormal_lymphatic_system1.53436515
22MP0004019_abnormal_vitamin_homeostasis1.46306141
23MP0003191_abnormal_cellular_cholesterol1.39403905
24MP0005408_hypopigmentation1.35230217
25MP0005319_abnormal_enzyme/_coenzyme1.18676298
26MP0001661_extended_life_span1.18131939
27MP0005451_abnormal_body_composition1.18115627
28MP0009643_abnormal_urine_homeostasis1.07835523
29MP0002132_abnormal_respiratory_system1.03850863
30MP0000598_abnormal_liver_morphology1.02564114
31MP0009053_abnormal_anal_canal0.91967372
32MP0001915_intracranial_hemorrhage0.91750878
33MP0000604_amyloidosis0.91468209
34MP0005084_abnormal_gallbladder_morpholo0.91116547
35MP0002971_abnormal_brown_adipose0.90615819
36MP0005187_abnormal_penis_morphology0.86917249
37MP0002928_abnormal_bile_duct0.86223756
38MP0003879_abnormal_hair_cell0.84233818
39MP0003690_abnormal_glial_cell0.84150843
40MP0005376_homeostasis/metabolism_phenot0.83986246
41MP0003186_abnormal_redox_activity0.83759575
42MP0005058_abnormal_lysosome_morphology0.83300022
43MP0009642_abnormal_blood_homeostasis0.83290989
44MP0005584_abnormal_enzyme/coenzyme_acti0.81631193
45MP0008469_abnormal_protein_level0.77514382
46MP0003638_abnormal_response/metabolism_0.76910541
47MP0003011_delayed_dark_adaptation0.76550419
48MP0002168_other_aberrant_phenotype0.75736077
49MP0005395_other_phenotype0.73015050
50MP0003656_abnormal_erythrocyte_physiolo0.72714995
51MP0005636_abnormal_mineral_homeostasis0.69982052
52MP0000566_synostosis0.59300039
53MP0002078_abnormal_glucose_homeostasis0.58756103
54MP0005220_abnormal_exocrine_pancreas0.57458312
55MP0009763_increased_sensitivity_to0.56404552
56MP0005334_abnormal_fat_pad0.55592722
57MP0005464_abnormal_platelet_physiology0.55109070
58MP0005670_abnormal_white_adipose0.53931148
59MP0002282_abnormal_trachea_morphology0.53889947
60MP0004883_abnormal_blood_vessel0.49849140
61MP0005448_abnormal_energy_balance0.49345322
62MP0002249_abnormal_larynx_morphology0.47902651
63MP0005266_abnormal_metabolism0.46526967
64MP0000249_abnormal_blood_vessel0.45211714
65MP0003075_altered_response_to0.44757342
66MP0005164_abnormal_response_to0.44746689
67MP0002089_abnormal_postnatal_growth/wei0.44138148
68MP0005535_abnormal_body_temperature0.42644583
69MP0010386_abnormal_urinary_bladder0.40387553
70MP0009764_decreased_sensitivity_to0.40213777
71MP0009115_abnormal_fat_cell0.39714989
72MP0003953_abnormal_hormone_level0.39543648
73MP0004272_abnormal_basement_membrane0.39306631
74MP0003329_amyloid_beta_deposits0.37299054
75MP0005023_abnormal_wound_healing0.36109691
76MP0005166_decreased_susceptibility_to0.35739348
77MP0008874_decreased_physiological_sensi0.35163080
78MP0002136_abnormal_kidney_physiology0.35119816
79MP0001756_abnormal_urination0.32885848
80MP0003943_abnormal_hepatobiliary_system0.32800611
81MP0004130_abnormal_muscle_cell0.31897787
82MP0005379_endocrine/exocrine_gland_phen0.31704223
83MP0002970_abnormal_white_adipose0.30428737
84MP0002909_abnormal_adrenal_gland0.30074907
85MP0003959_abnormal_lean_body0.29237129
86MP0004782_abnormal_surfactant_physiolog0.29069576
87MP0006036_abnormal_mitochondrial_physio0.28681547
88MP0003718_maternal_effect0.27190634
89MP0005646_abnormal_pituitary_gland0.26585086
90MP0000639_abnormal_adrenal_gland0.24738211
91MP0009785_altered_susceptibility_to0.24238558
92MP0001944_abnormal_pancreas_morphology0.23977519
93MP0003632_abnormal_nervous_system0.23776696
94MP0005197_abnormal_uvea_morphology0.22859754
95MP0000920_abnormal_myelination0.21431959
96MP0008872_abnormal_physiological_respon0.20397974
97MP0002822_catalepsy0.20258396
98MP0005167_abnormal_blood-brain_barrier0.19951016
99MP0003183_abnormal_peptide_metabolism0.19662368
100MP0001845_abnormal_inflammatory_respons0.18858932

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)9.02141755
2Complement deficiency (HP:0004431)8.31189474
3Hypobetalipoproteinemia (HP:0003563)7.05671440
4Abnormality of aromatic amino acid family metabolism (HP:0004338)7.05003682
5Joint hemorrhage (HP:0005261)6.73161876
6Abnormality of complement system (HP:0005339)6.54242162
7Abnormality of pyrimidine metabolism (HP:0004353)6.36585061
8Systemic lupus erythematosus (HP:0002725)6.18745597
9Xanthomatosis (HP:0000991)6.10630502
10Glomerulonephritis (HP:0000099)5.23163264
11Intrahepatic cholestasis (HP:0001406)4.92851742
12Hyperlipoproteinemia (HP:0010980)4.87238606
13Conjugated hyperbilirubinemia (HP:0002908)4.36682782
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.31611303
15Abnormality of the common coagulation pathway (HP:0010990)4.17114383
16Hypolipoproteinemia (HP:0010981)4.10243861
17Recurrent gram-negative bacterial infections (HP:0005420)3.75082417
18Abnormality of the intrinsic pathway (HP:0010989)3.63169665
19Nephritis (HP:0000123)3.61190480
20Abnormal gallbladder physiology (HP:0012438)3.59977924
21Cholecystitis (HP:0001082)3.59977924
22Hypercholesterolemia (HP:0003124)3.49756385
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.37950625
24Spontaneous abortion (HP:0005268)3.33744140
25Menorrhagia (HP:0000132)3.30554098
26Delayed CNS myelination (HP:0002188)3.24798911
27Vascular calcification (HP:0004934)3.22512871
28Abnormality of nucleobase metabolism (HP:0010932)3.21282119
29Hyperammonemia (HP:0001987)3.19636390
30Hemorrhage of the eye (HP:0011885)3.17971514
31Mitral stenosis (HP:0001718)3.14320744
32Hyperglycinemia (HP:0002154)3.02917792
33Hypoalphalipoproteinemia (HP:0003233)2.99626921
34Fat malabsorption (HP:0002630)2.96004867
35Abnormality of glycine metabolism (HP:0010895)2.91288253
36Abnormality of serine family amino acid metabolism (HP:0010894)2.91288253
37Cardiovascular calcification (HP:0011915)2.86691453
38Generalized aminoaciduria (HP:0002909)2.81112375
39Gingival bleeding (HP:0000225)2.77919220
40Reduced antithrombin III activity (HP:0001976)2.77608570
41Rickets (HP:0002748)2.77543773
42Osteomalacia (HP:0002749)2.71147414
43Purpura (HP:0000979)2.69473637
44Hyperglycinuria (HP:0003108)2.63750014
45Abnormality of the Achilles tendon (HP:0005109)2.52724114
46Epidermoid cyst (HP:0200040)2.47176807
47Abnormality of methionine metabolism (HP:0010901)2.46810761
48Cholelithiasis (HP:0001081)2.42455151
49Abnormality of serum amino acid levels (HP:0003112)2.42294764
50Arthropathy (HP:0003040)2.42026188
51Pulmonary embolism (HP:0002204)2.41236946
52Steatorrhea (HP:0002570)2.38455853
53Abnormality of proline metabolism (HP:0010907)2.34769044
54Hydroxyprolinuria (HP:0003080)2.34769044
55Thrombophlebitis (HP:0004418)2.30918820
56Abnormal gallbladder morphology (HP:0012437)2.24101966
57Fair hair (HP:0002286)2.17869057
58Hypophosphatemic rickets (HP:0004912)2.16989801
59Hepatocellular carcinoma (HP:0001402)2.13060532
60Metabolic acidosis (HP:0001942)2.12554983
61Elevated alkaline phosphatase (HP:0003155)2.11691693
62Myocardial infarction (HP:0001658)2.08160186
63Abnormal biliary tract physiology (HP:0012439)2.07591075
64Bile duct proliferation (HP:0001408)2.07591075
65Hyperbilirubinemia (HP:0002904)2.01637693
66Deep venous thrombosis (HP:0002625)11.1058221
67Abnormality of monocarboxylic acid metabolism (HP:0010996)10.2538519
68Hyperphosphaturia (HP:0003109)1.99967453
69Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98856228
70Abnormal enzyme/coenzyme activity (HP:0012379)1.95565484
71Neonatal hypoglycemia (HP:0001998)1.94177399
72Abnormality of alkaline phosphatase activity (HP:0004379)1.93449393
73Irritability (HP:0000737)1.92265039
74Gangrene (HP:0100758)1.91714939
75Pancreatitis (HP:0001733)1.88938413
76Abnormality of sulfur amino acid metabolism (HP:0004339)1.88499784
77Atrioventricular block (HP:0001678)1.85003777
78Abnormality of vitamin metabolism (HP:0100508)1.82035041
79Abnormality of urine glucose concentration (HP:0011016)1.81231115
80Glycosuria (HP:0003076)1.81231115
81Reticulocytosis (HP:0001923)1.80758853
82Increased mean platelet volume (HP:0011877)1.80734493
83Abnormality of purine metabolism (HP:0004352)1.76768271
84Poikilocytosis (HP:0004447)1.76519189
85Sensorimotor neuropathy (HP:0007141)1.75841574
86Enlarged kidneys (HP:0000105)1.74019405
87Abnormal urine phosphate concentration (HP:0012599)1.70977660
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68937917
89Ketosis (HP:0001946)1.68726517
90Bifid scrotum (HP:0000048)1.68365120
91Epistaxis (HP:0000421)1.64358392
92Abnormality of the gallbladder (HP:0005264)1.64091717
93Hypophosphatemia (HP:0002148)1.63273272
94Increased serum ferritin (HP:0003281)1.61893829
95Alkalosis (HP:0001948)1.61564025
96Abnormal platelet volume (HP:0011876)1.61464896
97Mucopolysacchariduria (HP:0008155)1.59818003
98Urinary glycosaminoglycan excretion (HP:0003541)1.59818003
99Abnormality of carpal bone ossification (HP:0006257)1.57937647
100Late onset (HP:0003584)1.57496771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN17.04100135
2PIK3CG5.42309135
3FGFR44.55094912
4TRIB33.11879232
5SIK12.75724943
6BCKDK2.70013471
7RIPK12.61001848
8DYRK1B2.48036779
9PIK3CA2.35456321
10MAP3K32.08595868
11PRKACG2.01421690
12MAPK111.86643805
13FGFR31.85181358
14PRKAA21.61390156
15PDPK11.58149061
16TBK11.45870163
17PRKCG1.44065752
18MST1R1.30057144
19ICK1.28383861
20FGFR21.27187616
21TYK21.27090978
22MAP2K41.23540997
23PRPF4B1.17607076
24PKN21.16405414
25PDK11.15938906
26WNK41.12963477
27TAOK31.09239450
28CDK61.08132032
29MAP2K31.06453610
30MUSK1.06256639
31MAP3K111.04698885
32NEK91.00383505
33FRK0.96410793
34AKT30.92735500
35PRKCZ0.92151329
36STK380.90425496
37SGK2230.88746348
38SGK4940.88746348
39BLK0.86596400
40JAK10.83215130
41ABL20.82272052
42ARAF0.81881437
43IGF1R0.80224447
44ERBB20.78580416
45PRKAA10.77142582
46CSNK1D0.76664460
47SGK10.76191564
48MAP3K120.74798742
49CDK120.74553635
50MAP3K20.74260627
51PRKACA0.73351970
52TAOK20.71638769
53GRK60.70694155
54MYLK0.69064001
55CSF1R0.68049430
56NTRK30.67934790
57CAMK1D0.65830275
58PRKG10.64201676
59CDK40.63379616
60MET0.62411938
61MAP3K10.58829926
62SGK20.58322652
63EPHA40.58136465
64EPHA30.57513934
65PRKCA0.57178743
66CAMKK10.56404297
67RPS6KA30.55837440
68RET0.55025006
69PDK20.54984744
70PIM20.54587056
71GSK3A0.52168637
72AKT20.50136331
73LATS10.49360489
74SGK30.49352058
75PDGFRA0.48244747
76TGFBR20.46149590
77JAK20.45326035
78GRK10.45080226
79FGFR10.44736034
80MTOR0.43833665
81PRKCB0.43484607
82KSR20.43308173
83EIF2AK10.42265327
84MAPKAPK30.41735095
85MAP3K70.40971903
86IRAK30.40941754
87MAP3K50.40091839
88CSNK2A10.39751826
89CSNK1E0.39560376
90SRC0.39464727
91MAPK120.39071130
92INSRR0.37953314
93CSNK2A20.37799200
94MAPK70.37192306
95PRKACB0.36581983
96FER0.36154618
97NEK10.35057289
98CAMK1G0.34783499
99TNK20.34036007
100NLK0.33591770

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.40883518
2Complement and coagulation cascades_Homo sapiens_hsa046104.32322797
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.50859652
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.46871031
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.27338950
6Arginine biosynthesis_Homo sapiens_hsa002203.12432225
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.08289633
8* Retinol metabolism_Homo sapiens_hsa008302.95384727
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71476018
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.60597801
11Phenylalanine metabolism_Homo sapiens_hsa003602.56604480
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43529667
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.38858594
14* Chemical carcinogenesis_Homo sapiens_hsa052042.37685714
15Caffeine metabolism_Homo sapiens_hsa002322.37427240
16Fatty acid degradation_Homo sapiens_hsa000712.28019824
17* Steroid hormone biosynthesis_Homo sapiens_hsa001402.22641844
18Bile secretion_Homo sapiens_hsa049762.04641971
19Histidine metabolism_Homo sapiens_hsa003401.87131145
20Tyrosine metabolism_Homo sapiens_hsa003501.81847959
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76283972
22Butanoate metabolism_Homo sapiens_hsa006501.75546821
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.72133710
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61608745
25Tryptophan metabolism_Homo sapiens_hsa003801.60566994
26Starch and sucrose metabolism_Homo sapiens_hsa005001.60517527
27Peroxisome_Homo sapiens_hsa041461.53324362
28PPAR signaling pathway_Homo sapiens_hsa033201.51816069
29Biosynthesis of amino acids_Homo sapiens_hsa012301.50540027
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.49888293
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48097665
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.43491920
33Staphylococcus aureus infection_Homo sapiens_hsa051501.41323664
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.40086508
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39411654
36beta-Alanine metabolism_Homo sapiens_hsa004101.38705858
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38575298
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36000057
39Arginine and proline metabolism_Homo sapiens_hsa003301.31961590
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31379073
41Pyruvate metabolism_Homo sapiens_hsa006201.27610282
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11017389
43Linoleic acid metabolism_Homo sapiens_hsa005911.10729311
44Prion diseases_Homo sapiens_hsa050201.06827626
45Fat digestion and absorption_Homo sapiens_hsa049751.05990484
46Carbon metabolism_Homo sapiens_hsa012001.05020271
47Arachidonic acid metabolism_Homo sapiens_hsa005901.02447893
48Sulfur metabolism_Homo sapiens_hsa009200.98671628
49ABC transporters_Homo sapiens_hsa020100.96711558
50Sulfur relay system_Homo sapiens_hsa041220.91950453
51Propanoate metabolism_Homo sapiens_hsa006400.83079764
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82961313
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81328761
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77655412
55Fatty acid metabolism_Homo sapiens_hsa012120.77322519
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.64399653
57One carbon pool by folate_Homo sapiens_hsa006700.60588107
58Vitamin B6 metabolism_Homo sapiens_hsa007500.56514972
59Fructose and mannose metabolism_Homo sapiens_hsa000510.52674475
60Vitamin digestion and absorption_Homo sapiens_hsa049770.48268632
61* Metabolic pathways_Homo sapiens_hsa011000.46478720
62Steroid biosynthesis_Homo sapiens_hsa001000.44079388
63Lysine degradation_Homo sapiens_hsa003100.43347832
64Galactose metabolism_Homo sapiens_hsa000520.42558836
65Glycerolipid metabolism_Homo sapiens_hsa005610.37192603
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36347545
67Pertussis_Homo sapiens_hsa051330.35312727
68Insulin resistance_Homo sapiens_hsa049310.33634476
69Fatty acid elongation_Homo sapiens_hsa000620.31805232
70Glucagon signaling pathway_Homo sapiens_hsa049220.24878940
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22062314
72Glutathione metabolism_Homo sapiens_hsa004800.21842294
73Renin-angiotensin system_Homo sapiens_hsa046140.21783705
74Other glycan degradation_Homo sapiens_hsa005110.17856112
75Pentose phosphate pathway_Homo sapiens_hsa000300.17190250
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.16585863
77Fatty acid biosynthesis_Homo sapiens_hsa000610.10460451
78Systemic lupus erythematosus_Homo sapiens_hsa053220.09138536
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07277157
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06864616
81Folate biosynthesis_Homo sapiens_hsa007900.04873750
82AMPK signaling pathway_Homo sapiens_hsa041520.04382003
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.02345578
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2234741
85African trypanosomiasis_Homo sapiens_hsa05143-0.1959345
86Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1774100
87N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1757621
88Circadian rhythm_Homo sapiens_hsa04710-0.1563956
89Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1440449
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1374820
91Sphingolipid metabolism_Homo sapiens_hsa00600-0.1313505
92Insulin signaling pathway_Homo sapiens_hsa04910-0.1061632
93Type II diabetes mellitus_Homo sapiens_hsa04930-0.1018742
94Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0958052
95Serotonergic synapse_Homo sapiens_hsa04726-0.0658113
96Nitrogen metabolism_Homo sapiens_hsa00910-0.0655754
97Selenocompound metabolism_Homo sapiens_hsa00450-0.0516741
98Mineral absorption_Homo sapiens_hsa04978-0.0263519
99Amoebiasis_Homo sapiens_hsa05146-0.0202859
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0118947

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