ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glyoxylate metabolic process (GO:0046487)	6.61924062
2	cellular ketone body metabolic process (GO:0046950)	6.36756533
3	ketone body metabolic process (GO:1902224)	5.57932067
4	regulation of memory T cell differentiation (GO:0043380)	5.51921489
5	drug catabolic process (GO:0042737)	5.24695975
6	exogenous drug catabolic process (GO:0042738)	4.81647713
7	regulation of fibrinolysis (GO:0051917)	4.58659234
8	phenylpropanoid metabolic process (GO:0009698)	4.50368091
9	serine family amino acid catabolic process (GO:0009071)	4.46258885
10	epoxygenase P450 pathway (GO:0019373)	4.33307151
11	L-alpha-amino acid transmembrane transport (GO:1902475)	4.26361877
12	regulation of protein activation cascade (GO:2000257)	4.25295859
13	negative regulation of fibrinolysis (GO:0051918)	4.22106764
14	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.10366859
15	regulation of complement activation (GO:0030449)	3.97038246
16	L-phenylalanine catabolic process (GO:0006559)	3.97017701
17	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.97017701
18	cellular glucuronidation (GO:0052695)	3.90443566
19	centriole replication (GO:0007099)	3.90194679
20	negative regulation of protein activation cascade (GO:2000258)	3.85698199
21	drug metabolic process (GO:0017144)	3.75851274
22	glycine metabolic process (GO:0006544)	3.75492643
23	regulation of Golgi to plasma membrane protein transport (GO:0042996)	3.75438401
24	uronic acid metabolic process (GO:0006063)	3.72081378
25	glucuronate metabolic process (GO:0019585)	3.72081378
26	negative regulation of complement activation (GO:0045916)	3.70932058
27	macromolecular complex remodeling (GO:0034367)	3.66086968
28	plasma lipoprotein particle remodeling (GO:0034369)	3.66086968
29	protein-lipid complex remodeling (GO:0034368)	3.66086968
30	regulation of triglyceride catabolic process (GO:0010896)	3.62784624
31	L-phenylalanine metabolic process (GO:0006558)	3.54364301
32	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.54364301
33	complement activation, alternative pathway (GO:0006957)	3.51027254
34	arginine metabolic process (GO:0006525)	3.47442542
35	alkaloid metabolic process (GO:0009820)	3.47022830
36	oxidative demethylation (GO:0070989)	3.44216167
37	phospholipid efflux (GO:0033700)	3.43051574
38	regulation of guanylate cyclase activity (GO:0031282)	3.41021421
39	positive regulation of guanylate cyclase activity (GO:0031284)	3.39719145
40	very-low-density lipoprotein particle assembly (GO:0034379)	3.39675984
41	urea metabolic process (GO:0019627)	3.39641953
42	cholesterol efflux (GO:0033344)	3.37311371
43	high-density lipoprotein particle remodeling (GO:0034375)	3.27789522
44	regulation of hexokinase activity (GO:1903299)	3.26884180
45	regulation of glucokinase activity (GO:0033131)	3.26884180
46	peptidyl-glutamic acid modification (GO:0018200)	3.26438065
47	nitrogen cycle metabolic process (GO:0071941)	3.25557337
48	microtubule polymerization or depolymerization (GO:0031109)	3.25150567
49	pyrimidine nucleobase catabolic process (GO:0006208)	3.24728892
50	amino acid salvage (GO:0043102)	3.23782695
51	L-methionine salvage (GO:0071267)	3.23782695
52	L-methionine biosynthetic process (GO:0071265)	3.23782695
53	polyketide metabolic process (GO:0030638)	3.21657528
54	doxorubicin metabolic process (GO:0044598)	3.21657528
55	daunorubicin metabolic process (GO:0044597)	3.21657528
56	peptidyl-glutamic acid carboxylation (GO:0017187)	3.20550129
57	protein carboxylation (GO:0018214)	3.20550129
58	auditory receptor cell stereocilium organization (GO:0060088)	3.20063476
59	protein polyglutamylation (GO:0018095)	3.19720813
60	flavonoid metabolic process (GO:0009812)	3.18482136
61	reverse cholesterol transport (GO:0043691)	3.16804371
62	fructose metabolic process (GO:0006000)	3.16375267
63	negative regulation of sterol transport (GO:0032372)	3.16297073
64	negative regulation of cholesterol transport (GO:0032375)	3.16297073
65	aromatic amino acid family catabolic process (GO:0009074)	3.16111130
66	organelle disassembly (GO:1903008)	3.15331156
67	serine family amino acid metabolic process (GO:0009069)	3.15209512
68	bile acid and bile salt transport (GO:0015721)	3.15115769
69	protein targeting to Golgi (GO:0000042)	3.14855856
70	aldehyde catabolic process (GO:0046185)	3.12911827
71	S-adenosylmethionine metabolic process (GO:0046500)	3.10783300
72	urea cycle (GO:0000050)	3.10497765
73	heme transport (GO:0015886)	3.09864110
74	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.08510621
75	regulation of activation of Janus kinase activity (GO:0010533)	3.08260527
76	plasma lipoprotein particle organization (GO:0071827)	3.08024198
77	triglyceride homeostasis (GO:0070328)	3.07702720
78	acylglycerol homeostasis (GO:0055090)	3.07702720
79	regulation of meiosis I (GO:0060631)	3.06943523
80	iron-sulfur cluster assembly (GO:0016226)	3.06507214
81	metallo-sulfur cluster assembly (GO:0031163)	3.06507214
82	fibrinolysis (GO:0042730)	3.06398709
83	axoneme assembly (GO:0035082)	3.05507383
84	drug transmembrane transport (GO:0006855)	3.05431495
85	cytolysis (GO:0019835)	3.04359103
86	microtubule depolymerization (GO:0007019)	3.03798967
87	establishment of protein localization to Golgi (GO:0072600)	3.02945043
88	regulation of plasminogen activation (GO:0010755)	3.02916850
89	negative regulation of humoral immune response (GO:0002921)	2.99829220
90	ribonucleoprotein complex disassembly (GO:0032988)	2.97006014
91	mannosylation (GO:0097502)	2.96419752
92	arginine catabolic process (GO:0006527)	2.96168507
93	peroxisome fission (GO:0016559)	2.94052923
94	sulfur amino acid catabolic process (GO:0000098)	2.90027329
95	negative regulation of lipase activity (GO:0060192)	2.88404289
96	aminoglycoside antibiotic metabolic process (GO:0030647)	2.86967879
97	sperm motility (GO:0030317)	2.86418206
98	plasma lipoprotein particle assembly (GO:0034377)	2.86083971
99	bile acid metabolic process (GO:0008206)	2.86006303
100	blood coagulation, intrinsic pathway (GO:0007597)	2.84581310

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.71423231
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.33748698
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.05123065
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.03663208
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.01493126
6	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.60688351
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.60549680
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26583699
9	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.23347613
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.19823389
11	FUS_26573619_Chip-Seq_HEK293_Human	2.18337408
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.04122216
13	VDR_22108803_ChIP-Seq_LS180_Human	2.01379886
14	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.99185729
15	CBP_20019798_ChIP-Seq_JUKART_Human	1.99185729
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94566700
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93914390
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89268424
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.88795477
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.86359644
21	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.85507460
22	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.82582248
23	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.81864000
24	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.68456236
25	P300_19829295_ChIP-Seq_ESCs_Human	1.67172759
26	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.65855806
27	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.62155687
28	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.60819817
29	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.59722854
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.54814716
31	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.53471446
32	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.53060813
33	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.52452200
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.51256799
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50942485
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49985367
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.49866325
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.49710947
39	HTT_18923047_ChIP-ChIP_STHdh_Human	1.49548597
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46851317
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44133967
42	STAT3_23295773_ChIP-Seq_U87_Human	1.41160764
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40544337
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40108839
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40108839
46	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.38518718
47	EWS_26573619_Chip-Seq_HEK293_Human	1.38436440
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.37634306
49	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.36745726
50	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.35864561
51	AR_25329375_ChIP-Seq_VCAP_Human	1.34943097
52	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34621157
53	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.32607450
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.32145393
55	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.32061665
56	PHF8_20622853_ChIP-Seq_HELA_Human	1.31266855
57	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.30406659
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29681256
59	TCF4_23295773_ChIP-Seq_U87_Human	1.27906079
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.27825062
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27617053
62	AR_20517297_ChIP-Seq_VCAP_Human	1.27482981
63	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.26625817
64	RBPJ_21746931_ChIP-Seq_IB4_Human	1.24669323
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24106612
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23784178
67	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.22820195
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.22268057
69	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.22091931
70	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22027912
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.21043020
72	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.20831986
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20672522
74	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.20314520
75	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.18912718
76	CEBPB_22108803_ChIP-Seq_LS180_Human	1.17186881
77	ETV1_20927104_ChIP-Seq_GIST48_Human	1.17030401
78	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17002466
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15616828
80	CDX2_22108803_ChIP-Seq_LS180_Human	1.15324324
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14280476
82	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14267616
83	JUN_21703547_ChIP-Seq_K562_Human	1.13997617
84	NFYA_21822215_ChIP-Seq_K562_Human	1.12853600
85	MYC_19829295_ChIP-Seq_ESCs_Human	1.12110461
86	NFYB_21822215_ChIP-Seq_K562_Human	1.12006586
87	NCOR_22424771_ChIP-Seq_293T_Human	1.09790954
88	TP53_18474530_ChIP-ChIP_U2OS_Human	1.09575947
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09024824
90	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.07039154
91	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.06364728
92	BCAT_22108803_ChIP-Seq_LS180_Human	1.06356161
93	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06253987
94	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06253987
95	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.06002808
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04047863
97	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.03893599
98	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.03804408
99	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02632038
100	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01991927

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.05765521
2	MP0005360_urolithiasis	5.91962900
3	MP0003195_calcinosis	4.34692982
4	MP0005085_abnormal_gallbladder_physiolo	3.88801049
5	MP0002138_abnormal_hepatobiliary_system	3.88799490
6	MP0005365_abnormal_bile_salt	3.13239225
7	MP0008875_abnormal_xenobiotic_pharmacok	2.94167794
8	MP0003252_abnormal_bile_duct	2.56943203
9	MP0010329_abnormal_lipoprotein_level	2.50531009
10	MP0002132_abnormal_respiratory_system	2.30786914
11	MP0002876_abnormal_thyroid_physiology	2.15770336
12	MP0005645_abnormal_hypothalamus_physiol	2.14574272
13	MP0001764_abnormal_homeostasis	2.14126567
14	MP0009697_abnormal_copulation	2.04205024
15	MP0005332_abnormal_amino_acid	2.02813159
16	MP0001666_abnormal_nutrient_absorption	2.02427656
17	MP0005551_abnormal_eye_electrophysiolog	1.97163715
18	MP0001188_hyperpigmentation	1.86568740
19	MP0005410_abnormal_fertilization	1.84766741
20	MP0000569_abnormal_digit_pigmentation	1.69510783
21	MP0001486_abnormal_startle_reflex	1.67917783
22	MP0003122_maternal_imprinting	1.63787335
23	MP0003868_abnormal_feces_composition	1.62319790
24	MP0005174_abnormal_tail_pigmentation	1.55217511
25	MP0004019_abnormal_vitamin_homeostasis	1.49103927
26	MP0003183_abnormal_peptide_metabolism	1.44762910
27	MP0001929_abnormal_gametogenesis	1.40478673
28	MP0005379_endocrine/exocrine_gland_phen	1.38868760
29	MP0001984_abnormal_olfaction	1.36212529
30	MP0009840_abnormal_foam_cell	1.32196115
31	MP0008995_early_reproductive_senescence	1.30311031
32	MP0003011_delayed_dark_adaptation	1.27037724
33	MP0003698_abnormal_male_reproductive	1.24688500
34	MP0009046_muscle_twitch	1.23855365
35	MP0002736_abnormal_nociception_after	1.19968905
36	MP0009745_abnormal_behavioral_response	1.19446661
37	MP0002118_abnormal_lipid_homeostasis	1.18380534
38	MP0001963_abnormal_hearing_physiology	1.17088818
39	MP0001485_abnormal_pinna_reflex	1.16627825
40	MP0005376_homeostasis/metabolism_phenot	1.13904808
41	MP0005408_hypopigmentation	1.12391575
42	MP0002272_abnormal_nervous_system	1.08856336
43	MP0001501_abnormal_sleep_pattern	1.08722136
44	MP0000751_myopathy	1.07901562
45	MP0003646_muscle_fatigue	1.07710077
46	MP0005084_abnormal_gallbladder_morpholo	1.07139087
47	MP0008872_abnormal_physiological_respon	1.06167175
48	MP0004043_abnormal_pH_regulation	1.01244474
49	MP0003718_maternal_effect	1.00480300
50	MP0001986_abnormal_taste_sensitivity	0.99532366
51	MP0002928_abnormal_bile_duct	0.99386508
52	MP0002102_abnormal_ear_morphology	0.99347619
53	MP0001661_extended_life_span	0.99191775
54	MP0009780_abnormal_chondrocyte_physiolo	0.96241949
55	MP0005083_abnormal_biliary_tract	0.95703902
56	MP0002163_abnormal_gland_morphology	0.94398996
57	MP0005253_abnormal_eye_physiology	0.94240575
58	MP0004145_abnormal_muscle_electrophysio	0.93800638
59	MP0001727_abnormal_embryo_implantation	0.92628468
60	MP0004885_abnormal_endolymph	0.90131050
61	MP0000013_abnormal_adipose_tissue	0.89329122
62	MP0005319_abnormal_enzyme/_coenzyme	0.89300921
63	MP0003186_abnormal_redox_activity	0.89195747
64	MP0002229_neurodegeneration	0.87831403
65	MP0005636_abnormal_mineral_homeostasis	0.87255978
66	MP0005266_abnormal_metabolism	0.87157412
67	MP0005670_abnormal_white_adipose	0.83125627
68	MP0004147_increased_porphyrin_level	0.82952982
69	MP0000372_irregular_coat_pigmentation	0.82504164
70	MP0002160_abnormal_reproductive_system	0.77952114
71	MP0002572_abnormal_emotion/affect_behav	0.76731079
72	MP0000609_abnormal_liver_physiology	0.74897018
73	MP0005167_abnormal_blood-brain_barrier	0.73995682
74	MP0005394_taste/olfaction_phenotype	0.72850587
75	MP0005499_abnormal_olfactory_system	0.72850587
76	MP0002161_abnormal_fertility/fecundity	0.72372331
77	MP0002233_abnormal_nose_morphology	0.70572375
78	MP0002064_seizures	0.68063450
79	MP0005395_other_phenotype	0.66631371
80	MP0000015_abnormal_ear_pigmentation	0.65555325
81	MP0002909_abnormal_adrenal_gland	0.65254621
82	MP0002078_abnormal_glucose_homeostasis	0.64580559
83	MP0005535_abnormal_body_temperature	0.64419687
84	MP0009642_abnormal_blood_homeostasis	0.64067872
85	MP0001145_abnormal_male_reproductive	0.63922732
86	MP0004484_altered_response_of	0.63282797
87	MP0000747_muscle_weakness	0.63273100
88	MP0003633_abnormal_nervous_system	0.63090770
89	MP0004233_abnormal_muscle_weight	0.62394953
90	MP0002822_catalepsy	0.61742087
91	MP0002837_dystrophic_cardiac_calcinosis	0.61572630
92	MP0001968_abnormal_touch/_nociception	0.61555406
93	MP0003953_abnormal_hormone_level	0.61173144
94	MP0002557_abnormal_social/conspecific_i	0.61024923
95	MP0000026_abnormal_inner_ear	0.60885496
96	MP0000427_abnormal_hair_cycle	0.60556236
97	MP0006036_abnormal_mitochondrial_physio	0.60327651
98	MP0000653_abnormal_sex_gland	0.60132746
99	MP0005389_reproductive_system_phenotype	0.60057144
100	MP0004883_abnormal_blood_vessel	0.59692472

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.69018836
2	Prolonged partial thromboplastin time (HP:0003645)	4.59899213
3	Deep venous thrombosis (HP:0002625)	4.43425495
4	Renal cortical cysts (HP:0000803)	4.24404498
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.05343734
6	Hypobetalipoproteinemia (HP:0003563)	3.99756111
7	Hyperlipoproteinemia (HP:0010980)	3.95840400
8	Xanthomatosis (HP:0000991)	3.87301315
9	Retinal dysplasia (HP:0007973)	3.45183209
10	Epidermoid cyst (HP:0200040)	3.33646217
11	Abnormality of pyrimidine metabolism (HP:0004353)	3.32175533
12	Bile duct proliferation (HP:0001408)	3.22456413
13	Abnormal biliary tract physiology (HP:0012439)	3.22456413
14	Hyperglycinemia (HP:0002154)	3.20242092
15	Complement deficiency (HP:0004431)	3.13515657
16	Intrahepatic cholestasis (HP:0001406)	3.06093393
17	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.00545665
18	Abnormality of the renal cortex (HP:0011035)	3.00203158
19	Glycosuria (HP:0003076)	2.92083374
20	Abnormality of urine glucose concentration (HP:0011016)	2.92083374
21	Generalized aminoaciduria (HP:0002909)	2.86539566
22	Abnormality of DNA repair (HP:0003254)	2.78036357
23	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.77088337
24	Pancreatic cysts (HP:0001737)	2.75175838
25	Optic nerve hypoplasia (HP:0000609)	2.73674028
26	Hypolipoproteinemia (HP:0010981)	2.73212786
27	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.73002523
28	Absent speech (HP:0001344)	2.70995639
29	Chronic hepatic failure (HP:0100626)	2.66124225
30	Polyphagia (HP:0002591)	2.65489893
31	Reduced antithrombin III activity (HP:0001976)	2.64911958
32	3-Methylglutaconic aciduria (HP:0003535)	2.55918451
33	Acute encephalopathy (HP:0006846)	2.53594094
34	Joint hemorrhage (HP:0005261)	2.47994064
35	Reticulocytosis (HP:0001923)	2.45275091
36	Acanthocytosis (HP:0001927)	2.42083599
37	Cerebellar dysplasia (HP:0007033)	2.38153582
38	Glomerulonephritis (HP:0000099)	2.36825372
39	Abnormality of glycine metabolism (HP:0010895)	2.36178667
40	Abnormality of serine family amino acid metabolism (HP:0010894)	2.36178667
41	Hyperglycinuria (HP:0003108)	2.30394753
42	Hypoproteinemia (HP:0003075)	2.27008022
43	Conjugated hyperbilirubinemia (HP:0002908)	2.22788873
44	Hypoalphalipoproteinemia (HP:0003233)	2.22703021
45	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.22033366
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.21528899
47	Brushfield spots (HP:0001088)	2.19692333
48	Poikilocytosis (HP:0004447)	2.16398438
49	Type I transferrin isoform profile (HP:0003642)	2.12205169
50	Amblyopia (HP:0000646)	2.10482878
51	Supernumerary spleens (HP:0009799)	2.10425721
52	Retinal atrophy (HP:0001105)	2.09305236
53	Cerebral edema (HP:0002181)	2.04694753
54	Abnormality of complement system (HP:0005339)	2.03281440
55	Degeneration of anterior horn cells (HP:0002398)	2.01237545
56	Abnormality of the anterior horn cell (HP:0006802)	2.01237545
57	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97661790
58	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97661790
59	Hyperammonemia (HP:0001987)	1.95606504
60	Lethargy (HP:0001254)	1.93328352
61	Progressive inability to walk (HP:0002505)	1.93261767
62	Acute necrotizing encephalopathy (HP:0006965)	1.91593980
63	Lissencephaly (HP:0001339)	1.90769791
64	Limb dystonia (HP:0002451)	1.90631145
65	Abnormality of nucleobase metabolism (HP:0010932)	1.90506825
66	Hyperbilirubinemia (HP:0002904)	1.90380380
67	Pancreatic fibrosis (HP:0100732)	1.89132400
68	Delayed CNS myelination (HP:0002188)	1.88214700
69	Abnormality of the common coagulation pathway (HP:0010990)	1.87793865
70	Abnormal albumin level (HP:0012116)	1.87773887
71	Hypoalbuminemia (HP:0003073)	1.87773887
72	Hyperventilation (HP:0002883)	1.86273718
73	Abnormal protein glycosylation (HP:0012346)	1.84643360
74	Abnormal glycosylation (HP:0012345)	1.84643360
75	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.84643360
76	Abnormal protein N-linked glycosylation (HP:0012347)	1.84643360
77	Abnormality of the vitreous humor (HP:0004327)	1.82992870
78	True hermaphroditism (HP:0010459)	1.82854057
79	Abnormality of the ileum (HP:0001549)	1.82112755
80	Gaze-evoked nystagmus (HP:0000640)	1.81381184
81	Mesangial abnormality (HP:0001966)	1.81262311
82	Inability to walk (HP:0002540)	1.79715594
83	Abolished electroretinogram (ERG) (HP:0000550)	1.79521300
84	Hepatic necrosis (HP:0002605)	1.77767907
85	Metabolic acidosis (HP:0001942)	1.77050951
86	Febrile seizures (HP:0002373)	1.71980343
87	Meckel diverticulum (HP:0002245)	1.70603021
88	Abnormality of fatty-acid metabolism (HP:0004359)	1.70546823
89	Spastic tetraplegia (HP:0002510)	1.69344799
90	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.69330269
91	Gingival bleeding (HP:0000225)	1.68843634
92	Abnormality of macular pigmentation (HP:0008002)	1.68655756
93	Albinism (HP:0001022)	1.68298227
94	Abnormal gallbladder morphology (HP:0012437)	1.68078181
95	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.67460819
96	Dicarboxylic aciduria (HP:0003215)	1.67460819
97	Poikiloderma (HP:0001029)	1.66631350
98	Abnormality of dental color (HP:0011073)	1.64509711
99	Hyperphosphaturia (HP:0003109)	1.64294285
100	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.63720763

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	6.53983268
2	WNK3	4.44713885
3	TRIM28	4.16418178
4	PLK4	4.11831080
5	MAP3K4	3.84878553
6	MAP4K2	3.65850381
7	ZAK	2.76060502
8	ADRBK2	2.62590326
9	MAP2K7	2.32493928
10	EPHA3	2.06646451
11	MAPK13	2.02353465
12	NUAK1	1.75879459
13	STK38L	1.73537417
14	RPS6KA4	1.72015676
15	UHMK1	1.60285208
16	BCR	1.52926534
17	TAOK3	1.38405462
18	PLK2	1.32381493
19	CDK19	1.32304487
20	BRSK2	1.30196971
21	INSRR	1.27171540
22	FRK	1.23407988
23	OXSR1	1.21710098
24	BCKDK	1.16831478
25	MAP2K4	1.16795831
26	PINK1	1.05074456
27	SIK3	1.02529086
28	NME1	1.00396057
29	MARK1	0.99263879
30	NEK6	0.98717496
31	BMPR2	0.98227595
32	TLK1	0.97674645
33	MAPK11	0.96266444
34	PDK2	0.91657365
35	NTRK2	0.90296541
36	ACVR1B	0.89996634
37	DYRK1A	0.88766151
38	BRD4	0.88543149
39	STK38	0.80715157
40	MAP3K5	0.79780007
41	GRK1	0.77457376
42	RPS6KA5	0.75444866
43	CDK18	0.70742509
44	SRPK1	0.69138817
45	CAMK2G	0.66093223
46	DAPK2	0.64073643
47	CDC7	0.63388841
48	WNK4	0.62829231
49	PRKCG	0.61289749
50	PIK3CG	0.60945651
51	MAP3K12	0.60923452
52	CDK15	0.60899236
53	GRK7	0.59846179
54	PRKCE	0.59017797
55	CSNK1G3	0.58452753
56	CSNK1G1	0.58175989
57	CDK11A	0.55988836
58	CDK14	0.52551605
59	CAMK2B	0.52284628
60	TXK	0.51259671
61	TYK2	0.50319701
62	PRKD3	0.49905887
63	PRKCQ	0.49836624
64	PRKAA1	0.49038852
65	FER	0.48667582
66	CSNK1G2	0.48373119
67	PNCK	0.47094187
68	DYRK2	0.46556871
69	CAMK4	0.44795412
70	CDK3	0.44273583
71	CAMK2D	0.44074745
72	BMPR1B	0.43825778
73	PRKACG	0.42840617
74	CAMK2A	0.40964943
75	PRKAA2	0.40227495
76	PAK3	0.40024846
77	NTRK3	0.39291749
78	ERBB4	0.38501312
79	KSR1	0.37898606
80	PRKCZ	0.37516944
81	BRSK1	0.36541208
82	LMTK2	0.36461957
83	WEE1	0.35999082
84	PRKACA	0.35877006
85	LIMK1	0.35361000
86	RAF1	0.34682406
87	DYRK1B	0.33007911
88	ITK	0.32062410
89	PLK1	0.31943008
90	CSNK1A1	0.31281535
91	CDK5	0.31027138
92	SIK2	0.30771815
93	TESK1	0.30513222
94	VRK1	0.30373263
95	JAK1	0.30013380
96	SGK223	0.28204870
97	SGK494	0.28204870
98	NLK	0.27691253
99	ERBB2	0.26077253
100	MAP3K7	0.25503190

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.66638038
2	Butanoate metabolism_Homo sapiens_hsa00650	3.03481055
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.63715896
4	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.62323837
5	Retinol metabolism_Homo sapiens_hsa00830	2.57459765
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.47668344
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.43665441
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.39977590
9	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.30396513
10	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.23639795
11	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.17863313
12	Chemical carcinogenesis_Homo sapiens_hsa05204	2.15497262
13	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.15396414
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.09664635
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.06423387
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.99957576
17	Phenylalanine metabolism_Homo sapiens_hsa00360	1.98452862
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.97276928
19	Fatty acid degradation_Homo sapiens_hsa00071	1.95677483
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.94543538
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.94328780
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89633645
23	Caffeine metabolism_Homo sapiens_hsa00232	1.81278450
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.81256138
25	Arginine and proline metabolism_Homo sapiens_hsa00330	1.75052536
26	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.68829401
27	Peroxisome_Homo sapiens_hsa04146	1.68224757
28	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.64730661
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.63206978
30	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.61037512
31	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.59390499
32	Sulfur metabolism_Homo sapiens_hsa00920	1.54820136
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52432902
34	Bile secretion_Homo sapiens_hsa04976	1.30465563
35	Olfactory transduction_Homo sapiens_hsa04740	1.28975346
36	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.28810433
37	PPAR signaling pathway_Homo sapiens_hsa03320	1.28257608
38	Fat digestion and absorption_Homo sapiens_hsa04975	1.27233591
39	Propanoate metabolism_Homo sapiens_hsa00640	1.22702866
40	Steroid biosynthesis_Homo sapiens_hsa00100	1.20353946
41	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.14413190
42	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.14088247
43	Tyrosine metabolism_Homo sapiens_hsa00350	1.13383980
44	Phototransduction_Homo sapiens_hsa04744	1.10999706
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09651020
46	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.06903864
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04947666
48	ABC transporters_Homo sapiens_hsa02010	1.03875233
49	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.97898452
50	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.97082469
51	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.96749018
52	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.95842381
53	Histidine metabolism_Homo sapiens_hsa00340	0.92557826
54	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.92438726
55	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82495410
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.78858106
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.77441979
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76759287
59	Nicotine addiction_Homo sapiens_hsa05033	0.71940500
60	Metabolic pathways_Homo sapiens_hsa01100	0.71489629
61	Renin-angiotensin system_Homo sapiens_hsa04614	0.71100748
62	Carbon metabolism_Homo sapiens_hsa01200	0.69807430
63	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.69415168
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66299012
65	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.65384146
66	Nitrogen metabolism_Homo sapiens_hsa00910	0.65179329
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.62867822
68	RNA degradation_Homo sapiens_hsa03018	0.61232790
69	Oxidative phosphorylation_Homo sapiens_hsa00190	0.60376552
70	GABAergic synapse_Homo sapiens_hsa04727	0.59383789
71	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.59305542
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.58935932
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.57681772
74	Taste transduction_Homo sapiens_hsa04742	0.57009694
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55975839
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55416114
77	Sulfur relay system_Homo sapiens_hsa04122	0.53477224
78	Galactose metabolism_Homo sapiens_hsa00052	0.52939293
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50876358
80	Morphine addiction_Homo sapiens_hsa05032	0.47827437
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47300867
82	Fanconi anemia pathway_Homo sapiens_hsa03460	0.46784283
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38271814
84	Protein export_Homo sapiens_hsa03060	0.37412915
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.36285788
86	Fatty acid elongation_Homo sapiens_hsa00062	0.34540030
87	Glutathione metabolism_Homo sapiens_hsa00480	0.33735357
88	Circadian rhythm_Homo sapiens_hsa04710	0.32969495
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27702213
90	Serotonergic synapse_Homo sapiens_hsa04726	0.26804375
91	Parkinsons disease_Homo sapiens_hsa05012	0.25717093
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24949236
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.22532234
94	RNA polymerase_Homo sapiens_hsa03020	0.18909468
95	Folate biosynthesis_Homo sapiens_hsa00790	0.17602113
96	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.17494274
97	Sphingolipid metabolism_Homo sapiens_hsa00600	0.17467631
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.17002545
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.16558409
100	Oocyte meiosis_Homo sapiens_hsa04114	0.15716652

CYP3A7-CYP3A51P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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