CYP46A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.06176279
2synaptic vesicle maturation (GO:0016188)5.98645350
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.61441145
4locomotory exploration behavior (GO:0035641)5.59458940
5glutamate secretion (GO:0014047)5.12156527
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11654846
7vocalization behavior (GO:0071625)5.07621092
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.06118765
9regulation of memory T cell differentiation (GO:0043380)4.98575398
10synaptic vesicle exocytosis (GO:0016079)4.95126013
11regulation of establishment of cell polarity (GO:2000114)4.93914078
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.87900640
13kynurenine metabolic process (GO:0070189)4.87342286
14indole-containing compound catabolic process (GO:0042436)4.86046223
15indolalkylamine catabolic process (GO:0046218)4.86046223
16tryptophan catabolic process (GO:0006569)4.86046223
17regulation of glutamate receptor signaling pathway (GO:1900449)4.81482717
18regulation of synaptic vesicle exocytosis (GO:2000300)4.68029849
19cerebellar Purkinje cell differentiation (GO:0021702)4.61695568
20regulation of neuronal synaptic plasticity (GO:0048168)4.60889570
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.55875195
22neurotransmitter-gated ion channel clustering (GO:0072578)4.54054579
23negative regulation of multicellular organism growth (GO:0040015)4.52666000
24sex differentiation (GO:0007548)4.47974852
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.37079504
26protein localization to synapse (GO:0035418)4.36190513
27neurotransmitter secretion (GO:0007269)4.36048925
28neuronal action potential propagation (GO:0019227)4.35384255
29cytoplasmic mRNA processing body assembly (GO:0033962)4.34439884
30regulation of synapse structural plasticity (GO:0051823)4.33417724
31exploration behavior (GO:0035640)4.24334018
32gamma-aminobutyric acid transport (GO:0015812)4.22532544
33regulation of synaptic vesicle transport (GO:1902803)4.21685954
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.19970704
35regulation of establishment or maintenance of cell polarity (GO:0032878)4.08027329
36indolalkylamine metabolic process (GO:0006586)4.05981187
37tryptophan metabolic process (GO:0006568)4.05409044
38dendritic spine morphogenesis (GO:0060997)3.97036658
39synaptic transmission, glutamatergic (GO:0035249)3.96470639
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87678474
41regulation of MHC class I biosynthetic process (GO:0045343)3.84707444
42layer formation in cerebral cortex (GO:0021819)3.81596459
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81334874
44glutamate receptor signaling pathway (GO:0007215)3.81271073
45neuron-neuron synaptic transmission (GO:0007270)3.77006996
46long-term memory (GO:0007616)3.76619390
47regulation of dendritic spine morphogenesis (GO:0061001)3.75325355
48positive regulation of membrane potential (GO:0045838)3.71542481
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71130505
50neuron cell-cell adhesion (GO:0007158)3.67202930
51cellular potassium ion homeostasis (GO:0030007)3.63920374
52regulation of synaptic plasticity (GO:0048167)3.58749120
53positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.58055116
54prepulse inhibition (GO:0060134)3.53547490
55neuromuscular process controlling balance (GO:0050885)3.53483947
56indole-containing compound metabolic process (GO:0042430)3.53391292
57regulation of postsynaptic membrane potential (GO:0060078)3.49801148
58serotonin metabolic process (GO:0042428)3.49687058
59proline transport (GO:0015824)3.47597219
60neurotransmitter transport (GO:0006836)3.46260982
61behavioral response to ethanol (GO:0048149)3.45547085
62auditory behavior (GO:0031223)3.42991295
63transmission of nerve impulse (GO:0019226)3.42210198
64ADP metabolic process (GO:0046031)3.40227788
65auditory receptor cell stereocilium organization (GO:0060088)3.38715427
66regulation of action potential (GO:0098900)3.37933148
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.36523787
68behavioral response to nicotine (GO:0035095)3.36392178
69fucose catabolic process (GO:0019317)3.36027677
70L-fucose metabolic process (GO:0042354)3.36027677
71L-fucose catabolic process (GO:0042355)3.36027677
72neuromuscular process controlling posture (GO:0050884)3.34676910
73regulation of neurotransmitter levels (GO:0001505)3.34583165
74primary amino compound metabolic process (GO:1901160)3.34094726
75activation of protein kinase A activity (GO:0034199)3.33945533
76response to auditory stimulus (GO:0010996)3.31365148
77protein K11-linked deubiquitination (GO:0035871)3.31253113
78long-term synaptic potentiation (GO:0060291)3.31190866
79sodium ion export (GO:0071436)3.29905503
80central nervous system projection neuron axonogenesis (GO:0021952)3.29203085
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28804170
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27973782
83central nervous system neuron axonogenesis (GO:0021955)3.25809797
84positive regulation of vasculogenesis (GO:2001214)3.25803980
85positive regulation of neurotransmitter transport (GO:0051590)3.23732761
86behavioral response to cocaine (GO:0048148)3.22889618
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.22023898
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22013858
89negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21552343
90positive regulation of neurotransmitter secretion (GO:0001956)3.20094299
91glycine transport (GO:0015816)3.19473332
92regulation of neurotransmitter secretion (GO:0046928)3.17691797
93neuronal ion channel clustering (GO:0045161)3.14532056
94regulation of dendritic spine development (GO:0060998)3.13623825
95reflex (GO:0060004)3.13486732
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12532629
97cellular ketone body metabolic process (GO:0046950)3.11558292
98righting reflex (GO:0060013)3.11265444
99startle response (GO:0001964)3.10686644
100regulation of female receptivity (GO:0045924)3.10484233
101detection of mechanical stimulus involved in sensory perception (GO:0050974)3.10463358
102neural tube formation (GO:0001841)3.09227818
103detection of light stimulus involved in sensory perception (GO:0050962)3.05413097
104detection of light stimulus involved in visual perception (GO:0050908)3.05413097
105regulation of glutamate secretion (GO:0014048)3.04295666
106positive regulation of dendritic spine development (GO:0060999)3.03816601
107regulation of neurotransmitter transport (GO:0051588)3.03049113
108regulation of vesicle fusion (GO:0031338)3.02760375
109amine catabolic process (GO:0009310)3.02276768
110cellular biogenic amine catabolic process (GO:0042402)3.02276768
111postsynaptic membrane organization (GO:0001941)3.01339821
112gamma-aminobutyric acid signaling pathway (GO:0007214)3.00963477
113behavioral fear response (GO:0001662)3.00850966
114behavioral defense response (GO:0002209)3.00850966
115positive regulation of synapse maturation (GO:0090129)3.00739713
116adult walking behavior (GO:0007628)3.00379343
117neuron recognition (GO:0008038)3.00135355
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97425758
119regulation of sarcomere organization (GO:0060297)2.97324072
120axon ensheathment in central nervous system (GO:0032291)2.97057818
121central nervous system myelination (GO:0022010)2.97057818
122NAD biosynthetic process (GO:0009435)2.96921842
123cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96410226
124membrane hyperpolarization (GO:0060081)2.95824847
125neuronal action potential (GO:0019228)2.95467497
126centrosome duplication (GO:0051298)2.93846433
127membrane depolarization (GO:0051899)2.93700668
128L-amino acid import (GO:0043092)2.92701604
129response to histamine (GO:0034776)2.92477366
130lipid translocation (GO:0034204)2.91954426
131phospholipid translocation (GO:0045332)2.91954426
132positive regulation of synaptic transmission (GO:0050806)2.91283941
133learning (GO:0007612)2.90189660
134dendritic spine organization (GO:0097061)2.89854793
135negative regulation of mast cell activation (GO:0033004)2.89743558
136negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89305675
137cell communication by electrical coupling (GO:0010644)2.88163987
138regulation of synaptic transmission (GO:0050804)2.87334938
139synaptic vesicle endocytosis (GO:0048488)2.85740463
140neuromuscular process (GO:0050905)2.85093866
141mating behavior (GO:0007617)2.85056930
142negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84742000
143aromatic amino acid family catabolic process (GO:0009074)2.84403426
144ketone body metabolic process (GO:1902224)2.84184793
145negative regulation of type 2 immune response (GO:0002829)2.84136052
146dendrite morphogenesis (GO:0048813)2.83124842
147membrane depolarization during action potential (GO:0086010)2.82168332
148striatum development (GO:0021756)2.80674702
149signal peptide processing (GO:0006465)2.80434433
150inner ear receptor stereocilium organization (GO:0060122)2.80055178
151fear response (GO:0042596)2.79015864
152female mating behavior (GO:0060180)2.78636050
153negative regulation of dendrite development (GO:2000171)2.77880714
154G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77828860
155alanine transport (GO:0032328)2.76770339
156synaptic transmission, dopaminergic (GO:0001963)2.76288028
157regulation of voltage-gated calcium channel activity (GO:1901385)2.75992985
158negative regulation of amino acid transport (GO:0051956)2.75829678
159synaptic transmission (GO:0007268)2.75825449
160cilium or flagellum-dependent cell motility (GO:0001539)2.75596527
161retinal cone cell development (GO:0046549)2.73881502
162acrosome assembly (GO:0001675)2.71464543
163nucleoside diphosphate catabolic process (GO:0009134)2.69742660
164benzene-containing compound metabolic process (GO:0042537)2.69379581
165regulation of vasculogenesis (GO:2001212)2.68897264
166potassium ion transmembrane transport (GO:0071805)2.67012676
167cellular potassium ion transport (GO:0071804)2.67012676
168synaptic transmission, cholinergic (GO:0007271)2.65652818
169protein localization to cilium (GO:0061512)2.64917637
170negative regulation of receptor-mediated endocytosis (GO:0048261)2.63846005
171tachykinin receptor signaling pathway (GO:0007217)2.63226090
172regulation of interleukin-13 production (GO:0032656)2.61888115
173establishment of protein localization to Golgi (GO:0072600)2.61259248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29069357
2GBX2_23144817_ChIP-Seq_PC3_Human3.08089406
3VDR_22108803_ChIP-Seq_LS180_Human3.02413438
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02268517
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00282246
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.98058190
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87407312
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.68266541
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66520435
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66520435
11DROSHA_22980978_ChIP-Seq_HELA_Human2.63237580
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57327095
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55281678
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53730344
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52078270
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.45580626
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43028693
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37516314
19IGF1R_20145208_ChIP-Seq_DFB_Human2.34945857
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32165440
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.28850539
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.24682300
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24535430
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22649538
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.19430685
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.19378917
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18862476
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14574043
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.14022969
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09179036
31* RNF2_27304074_Chip-Seq_ESCs_Mouse2.02433095
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99113875
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.93855415
34ER_23166858_ChIP-Seq_MCF-7_Human1.88499613
35BCAT_22108803_ChIP-Seq_LS180_Human1.88240026
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.87001990
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86207292
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79734091
39FUS_26573619_Chip-Seq_HEK293_Human1.77750363
40AR_21572438_ChIP-Seq_LNCaP_Human1.76315319
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76101434
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68983837
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54652809
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53000025
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50883719
46CBP_20019798_ChIP-Seq_JUKART_Human1.48612356
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48612356
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47043441
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45895199
50TAF15_26573619_Chip-Seq_HEK293_Human1.45490078
51* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43549318
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41126818
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41126818
54SMAD4_21799915_ChIP-Seq_A2780_Human1.38547783
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38487671
56EWS_26573619_Chip-Seq_HEK293_Human1.37936904
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36920717
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33401104
59TCF4_22108803_ChIP-Seq_LS180_Human1.32619517
60* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30733550
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28973634
62* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28539705
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.27760956
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.27031921
65* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26393275
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.25937822
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25602070
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.25292411
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24424970
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.22789642
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22787573
72KDM2B_26808549_Chip-Seq_REH_Human1.21275935
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18409744
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18325372
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18266390
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17898254
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17897646
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15859661
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15281169
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14599230
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.14400613
82KDM2B_26808549_Chip-Seq_K562_Human1.13903967
83* AR_19668381_ChIP-Seq_PC3_Human1.13844706
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.13769743
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13499047
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12548549
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11356554
88P53_22387025_ChIP-Seq_ESCs_Mouse1.10891611
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.10773230
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10503512
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10476747
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.09766323
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09756547
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08974138
95P300_19829295_ChIP-Seq_ESCs_Human1.08070482
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07394605
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07217500
98TP53_22573176_ChIP-Seq_HFKS_Human1.06641139
99* CDX2_22108803_ChIP-Seq_LS180_Human1.06548808
100NANOG_19829295_ChIP-Seq_ESCs_Human1.05971226
101SOX2_19829295_ChIP-Seq_ESCs_Human1.05971226
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05813125
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05696025
104STAT3_23295773_ChIP-Seq_U87_Human1.05426053
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05120984
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05105622
107* AR_25329375_ChIP-Seq_VCAP_Human1.05036234
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04870837
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04653228
110* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03796447
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03757187
112OCT1_27270436_Chip-Seq_PROSTATE_Human1.02603199
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02562590
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.01681995
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01631160
116RNF2_27304074_Chip-Seq_NSC_Mouse1.01329217
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01258151
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.01027006
119ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00393932
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99408440
121ZNF274_21170338_ChIP-Seq_K562_Hela0.99120252
122* CTCF_27219007_Chip-Seq_Bcells_Human0.98906031
123ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98799286
124* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97062462
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.96486513
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95699267
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95539414
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93204086
129* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93011967
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.91513375
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.90737577
132TCF4_23295773_ChIP-Seq_U87_Human0.90490322
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90248604
134CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90062325
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89874183
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89652252
137RXR_22108803_ChIP-Seq_LS180_Human0.89613318
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87769962
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.86726534
140SMAD_19615063_ChIP-ChIP_OVARY_Human0.86418444
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86237325
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86054121
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85775373
144CBX2_27304074_Chip-Seq_ESCs_Mouse0.85339199
145RXR_22158963_ChIP-Seq_LIVER_Mouse0.85244157
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.84779520
147YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83603520
148AHR_22903824_ChIP-Seq_MCF-7_Human0.82708915
149RUNX2_22187159_ChIP-Seq_PCA_Human0.81929669
150KLF4_19829295_ChIP-Seq_ESCs_Human0.81642635
151* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81503877
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80649806
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.80559828
154TP53_16413492_ChIP-PET_HCT116_Human0.80517531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.86549121
2MP0002822_catalepsy4.68497569
3MP0003880_abnormal_central_pattern4.59598448
4MP0003635_abnormal_synaptic_transmissio4.14719791
5MP0000569_abnormal_digit_pigmentation3.87471537
6MP0009745_abnormal_behavioral_response3.56672940
7MP0004270_analgesia3.50365585
8MP0002063_abnormal_learning/memory/cond3.36125705
9MP0002064_seizures3.18764337
10MP0009046_muscle_twitch2.86094409
11MP0002572_abnormal_emotion/affect_behav2.74947849
12MP0001968_abnormal_touch/_nociception2.71062437
13MP0001486_abnormal_startle_reflex2.59826581
14MP0005423_abnormal_somatic_nervous2.52618402
15MP0002272_abnormal_nervous_system2.52126884
16MP0003329_amyloid_beta_deposits2.32791976
17MP0001501_abnormal_sleep_pattern2.31584316
18MP0002734_abnormal_mechanical_nocicepti2.26826494
19MP0001986_abnormal_taste_sensitivity2.16169641
20MP0008877_abnormal_DNA_methylation2.03919572
21MP0002736_abnormal_nociception_after1.99921301
22MP0009780_abnormal_chondrocyte_physiolo1.92060980
23MP0001440_abnormal_grooming_behavior1.90980128
24MP0002733_abnormal_thermal_nociception1.80356673
25MP0005646_abnormal_pituitary_gland1.80182277
26MP0002909_abnormal_adrenal_gland1.78214159
27MP0001970_abnormal_pain_threshold1.72771721
28MP0008569_lethality_at_weaning1.69871632
29MP0004858_abnormal_nervous_system1.69414470
30MP0004924_abnormal_behavior1.67601593
31MP0005386_behavior/neurological_phenoty1.67601593
32MP0003011_delayed_dark_adaptation1.66805115
33MP0002735_abnormal_chemical_nociception1.65540359
34MP0004147_increased_porphyrin_level1.63707606
35MP0002067_abnormal_sensory_capabilities1.63491955
36MP0005253_abnormal_eye_physiology1.63124383
37MP0002102_abnormal_ear_morphology1.62667447
38MP0004811_abnormal_neuron_physiology1.60591472
39MP0002139_abnormal_hepatobiliary_system1.60221120
40MP0002557_abnormal_social/conspecific_i1.59227397
41MP0003879_abnormal_hair_cell1.54828501
42MP0001984_abnormal_olfaction1.53061380
43MP0005085_abnormal_gallbladder_physiolo1.52148783
44MP0001529_abnormal_vocalization1.50265855
45MP0003633_abnormal_nervous_system1.49702366
46MP0000427_abnormal_hair_cycle1.47437602
47MP0003646_muscle_fatigue1.45752886
48MP0003075_altered_response_to1.45340205
49MP0003690_abnormal_glial_cell1.43979174
50MP0004885_abnormal_endolymph1.43814466
51MP0010386_abnormal_urinary_bladder1.42280295
52MP0001485_abnormal_pinna_reflex1.40376250
53MP0000604_amyloidosis1.39332525
54MP0000955_abnormal_spinal_cord1.37711155
55MP0002184_abnormal_innervation1.36952340
56MP0005360_urolithiasis1.35525745
57MP0002066_abnormal_motor_capabilities/c1.34846025
58MP0000778_abnormal_nervous_system1.34619489
59MP0001502_abnormal_circadian_rhythm1.28704457
60MP0005174_abnormal_tail_pigmentation1.26304152
61MP0006072_abnormal_retinal_apoptosis1.25627231
62MP0001905_abnormal_dopamine_level1.25560561
63MP0003631_nervous_system_phenotype1.24008406
64MP0008872_abnormal_physiological_respon1.22778225
65MP0002882_abnormal_neuron_morphology1.22272730
66MP0004142_abnormal_muscle_tone1.20719676
67MP0002638_abnormal_pupillary_reflex1.19706805
68MP0008874_decreased_physiological_sensi1.19023537
69MP0008875_abnormal_xenobiotic_pharmacok1.13792896
70MP0005535_abnormal_body_temperature1.10117004
71MP0006276_abnormal_autonomic_nervous1.09032442
72MP0000631_abnormal_neuroendocrine_gland1.07175230
73MP0000371_diluted_coat_color1.06000152
74MP0001177_atelectasis1.05701600
75MP0005365_abnormal_bile_salt1.03622933
76MP0002069_abnormal_eating/drinking_beha1.01468970
77MP0005167_abnormal_blood-brain_barrier1.01295172
78MP0005171_absent_coat_pigmentation1.00914414
79MP0000920_abnormal_myelination1.00310318
80MP0010329_abnormal_lipoprotein_level0.99658998
81MP0002090_abnormal_vision0.96966370
82MP0008057_abnormal_DNA_replication0.96931602
83MP0003950_abnormal_plasma_membrane0.95420337
84MP0005645_abnormal_hypothalamus_physiol0.94576745
85MP0002229_neurodegeneration0.94031795
86MP0008961_abnormal_basal_metabolism0.93385549
87MP0002152_abnormal_brain_morphology0.91755330
88MP0004215_abnormal_myocardial_fiber0.89539708
89MP0003632_abnormal_nervous_system0.88342665
90MP0005310_abnormal_salivary_gland0.88327723
91MP0000383_abnormal_hair_follicle0.87839884
92MP0000372_irregular_coat_pigmentation0.87067405
93MP0003787_abnormal_imprinting0.84436713
94MP0005647_abnormal_sex_gland0.84110547
95MP0005551_abnormal_eye_electrophysiolog0.83790056
96MP0002234_abnormal_pharynx_morphology0.82462926
97MP0003136_yellow_coat_color0.82428299
98MP0005410_abnormal_fertilization0.81522739
99MP0002928_abnormal_bile_duct0.80066334
100MP0002138_abnormal_hepatobiliary_system0.79761196
101MP0003634_abnormal_glial_cell0.79691013
102MP0000013_abnormal_adipose_tissue0.78773883
103MP0000751_myopathy0.78249099
104MP0004085_abnormal_heartbeat0.76925121
105MP0005670_abnormal_white_adipose0.75429287
106MP0000026_abnormal_inner_ear0.74788746
107MP0000230_abnormal_systemic_arterial0.71935297
108MP0002876_abnormal_thyroid_physiology0.70882801
109MP0003718_maternal_effect0.69515344
110MP0003119_abnormal_digestive_system0.69380960
111MP0003283_abnormal_digestive_organ0.68127878
112MP0005075_abnormal_melanosome_morpholog0.67316563
113MP0010234_abnormal_vibrissa_follicle0.66975532
114MP0003698_abnormal_male_reproductive0.66185472
115MP0005195_abnormal_posterior_eye0.64382732
116MP0000015_abnormal_ear_pigmentation0.64321080
117MP0005584_abnormal_enzyme/coenzyme_acti0.63871052
118MP0004130_abnormal_muscle_cell0.61679519
119MP0001963_abnormal_hearing_physiology0.61606011
120MP0005166_decreased_susceptibility_to0.60241516
121* MP0002118_abnormal_lipid_homeostasis0.60140713
122MP0004043_abnormal_pH_regulation0.60135959
123MP0003122_maternal_imprinting0.58243270
124MP0001188_hyperpigmentation0.57956254
125MP0005332_abnormal_amino_acid0.57654265
126MP0003137_abnormal_impulse_conducting0.57061314
127MP0005448_abnormal_energy_balance0.54995956
128MP0005499_abnormal_olfactory_system0.54359796
129MP0005394_taste/olfaction_phenotype0.54359796
130MP0001664_abnormal_digestion0.53999642
131MP0003172_abnormal_lysosome_physiology0.53924275
132MP0003195_calcinosis0.53848460
133MP0005409_darkened_coat_color0.53030342
134MP0004145_abnormal_muscle_electrophysio0.52335204
135MP0003252_abnormal_bile_duct0.52314876
136MP0002837_dystrophic_cardiac_calcinosis0.51577797
137MP0004742_abnormal_vestibular_system0.51335016
138MP0002752_abnormal_somatic_nervous0.51109562

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.94154006
2Focal motor seizures (HP:0011153)7.49805025
3Focal seizures (HP:0007359)5.57810390
4Visual hallucinations (HP:0002367)4.76484535
5Epileptic encephalopathy (HP:0200134)4.38964792
6Atonic seizures (HP:0010819)4.00400354
7Generalized tonic-clonic seizures (HP:0002069)3.88656916
8Absence seizures (HP:0002121)3.86402194
9Febrile seizures (HP:0002373)3.81864772
10Action tremor (HP:0002345)3.76184075
11Pancreatic cysts (HP:0001737)3.65688488
12Progressive cerebellar ataxia (HP:0002073)3.59294785
13Impaired vibration sensation in the lower limbs (HP:0002166)3.58138719
14Supranuclear gaze palsy (HP:0000605)3.57504191
15Torticollis (HP:0000473)3.56284450
16Poor eye contact (HP:0000817)3.55714163
17Dialeptic seizures (HP:0011146)3.55497889
18Ankle clonus (HP:0011448)3.50156624
19Neurofibrillary tangles (HP:0002185)3.47973815
20Dysdiadochokinesis (HP:0002075)3.38648243
21Pancreatic fibrosis (HP:0100732)3.36658177
22Postural instability (HP:0002172)3.36218033
23Abnormal social behavior (HP:0012433)3.35593315
24Impaired social interactions (HP:0000735)3.35593315
25Prostate neoplasm (HP:0100787)3.32851616
26Depression (HP:0000716)3.31476703
27Focal dystonia (HP:0004373)3.30864069
28Anxiety (HP:0000739)3.29392106
29Dysmetria (HP:0001310)3.27589975
30Urinary bladder sphincter dysfunction (HP:0002839)3.24897553
31Abnormality of the lower motor neuron (HP:0002366)3.24163427
32True hermaphroditism (HP:0010459)3.21707579
33Hyperventilation (HP:0002883)3.17077404
34Cerebral inclusion bodies (HP:0100314)3.14937744
35Pendular nystagmus (HP:0012043)3.12089464
36Broad-based gait (HP:0002136)3.10432349
37Craniofacial dystonia (HP:0012179)3.07889075
38Status epilepticus (HP:0002133)3.06917410
39Gaze-evoked nystagmus (HP:0000640)3.05111658
40Abnormal eating behavior (HP:0100738)2.93233539
41Intention tremor (HP:0002080)2.91179431
42Congenital stationary night blindness (HP:0007642)2.91173143
43Spastic gait (HP:0002064)2.84532981
44Abnormality of midbrain morphology (HP:0002418)2.81890751
45Molar tooth sign on MRI (HP:0002419)2.81890751
46Urinary urgency (HP:0000012)2.76049724
47Protruding tongue (HP:0010808)2.75302394
48Papilledema (HP:0001085)2.71907799
49Nephronophthisis (HP:0000090)2.71728361
50Scanning speech (HP:0002168)2.70651045
51Attenuation of retinal blood vessels (HP:0007843)2.69784397
52Hemiplegia (HP:0002301)2.64383710
53Mutism (HP:0002300)2.61929628
54Annular pancreas (HP:0001734)2.61130920
55Clumsiness (HP:0002312)2.59557594
56Bradykinesia (HP:0002067)2.58684276
57Abnormality of macular pigmentation (HP:0008002)2.58616710
58Truncal ataxia (HP:0002078)2.58414746
59Amblyopia (HP:0000646)2.58088273
60Megalencephaly (HP:0001355)2.57382227
61Impaired vibratory sensation (HP:0002495)2.56447856
62Abolished electroretinogram (ERG) (HP:0000550)2.55540268
63Congenital sensorineural hearing impairment (HP:0008527)2.52987751
64Increased corneal curvature (HP:0100692)2.52448846
65Keratoconus (HP:0000563)2.52448846
66Epileptiform EEG discharges (HP:0011182)2.49865850
67Stereotypic behavior (HP:0000733)2.47403193
68Fair hair (HP:0002286)2.46993958
69Abnormality of the renal cortex (HP:0011035)2.45503585
70Cystic liver disease (HP:0006706)2.43912057
71Abnormality of the hepatic vasculature (HP:0006707)2.43160063
72EEG with generalized epileptiform discharges (HP:0011198)2.42568687
73Hemiparesis (HP:0001269)2.42514704
74Abnormality of the renal medulla (HP:0100957)2.39337680
75Generalized myoclonic seizures (HP:0002123)2.37219196
76Hypsarrhythmia (HP:0002521)2.35558888
77Decreased central vision (HP:0007663)2.34770710
78Chronic hepatic failure (HP:0100626)2.33777188
79Impaired smooth pursuit (HP:0007772)2.33589020
80Deep venous thrombosis (HP:0002625)2.31283470
81Severe visual impairment (HP:0001141)2.30653380
82Medial flaring of the eyebrow (HP:0010747)2.28892077
83Excessive salivation (HP:0003781)2.28641054
84Drooling (HP:0002307)2.28641054
85Ventricular fibrillation (HP:0001663)2.26760420
86Progressive inability to walk (HP:0002505)2.26158126
87Dysmetric saccades (HP:0000641)2.25949050
88Clonus (HP:0002169)2.25586361
89Resting tremor (HP:0002322)2.23365225
90Abnormality of the corticospinal tract (HP:0002492)2.22896118
91Genetic anticipation (HP:0003743)2.21351248
92Lower limb muscle weakness (HP:0007340)2.21294497
93Type II lissencephaly (HP:0007260)2.14728497
94Tetraplegia (HP:0002445)2.13413778
95Termporal pattern (HP:0011008)2.13039308
96Insidious onset (HP:0003587)2.13039308
97Bony spicule pigmentary retinopathy (HP:0007737)2.11868564
98Diplopia (HP:0000651)2.08257721
99Abnormality of binocular vision (HP:0011514)2.08257721
100Chorioretinal atrophy (HP:0000533)2.08054848
101Abnormality of ocular smooth pursuit (HP:0000617)2.07947499
102Gait imbalance (HP:0002141)2.06653020
103Limb ataxia (HP:0002070)2.02114846
104Generalized hypopigmentation of hair (HP:0011358)2.02016272
105Rigidity (HP:0002063)2.01323033
106Abnormality of saccadic eye movements (HP:0000570)2.00401633
107Aplasia/Hypoplasia of the tibia (HP:0005772)2.00144710
108Absent/shortened dynein arms (HP:0200106)1.99270992
109Dynein arm defect of respiratory motile cilia (HP:0012255)1.99270992
110Retinitis pigmentosa (HP:0000510)1.96959204
111Postural tremor (HP:0002174)1.96653832
112Delusions (HP:0000746)1.95450370
113Incomplete penetrance (HP:0003829)1.94953523
114Neuronal loss in central nervous system (HP:0002529)1.94183065
115Abnormality of the periventricular white matter (HP:0002518)1.93992621
116Bundle branch block (HP:0011710)1.93047263
117Spastic tetraparesis (HP:0001285)1.92811544
118Pointed chin (HP:0000307)1.92177105
119Hypochromic microcytic anemia (HP:0004840)1.91808034
120Gait ataxia (HP:0002066)1.91083063
121Polyphagia (HP:0002591)1.90918658
122Abnormal drinking behavior (HP:0030082)1.90829084
123Polydipsia (HP:0001959)1.90829084
124Tubular atrophy (HP:0000092)1.90239004
125Blue irides (HP:0000635)1.90032324
126Ankyloglossia (HP:0010296)1.89898870
127Sclerocornea (HP:0000647)1.89392448
128Fetal akinesia sequence (HP:0001989)1.89237536
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87322200
130Insomnia (HP:0100785)1.87297334
131Hyperlipoproteinemia (HP:0010980)1.86505192
132Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86418523
133Inability to walk (HP:0002540)1.86125194
134Lower limb amyotrophy (HP:0007210)1.85924826
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.85680131
136Abnormal gallbladder physiology (HP:0012438)1.84818953
137Cholecystitis (HP:0001082)1.84818953
138Pheochromocytoma (HP:0002666)1.84678050
139Absent speech (HP:0001344)1.83387711
140Limb dystonia (HP:0002451)1.83111442
141Abnormal ciliary motility (HP:0012262)1.82359490
142Widely spaced teeth (HP:0000687)1.81901000
143Psychosis (HP:0000709)1.81511499
144Delayed CNS myelination (HP:0002188)1.79973385
145Aplasia involving bones of the extremities (HP:0009825)1.78947622
146Aplasia of the phalanges of the hand (HP:0009802)1.78947622
147Congenital primary aphakia (HP:0007707)1.78508347
148Central scotoma (HP:0000603)1.78061275
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75719916
150Oculomotor apraxia (HP:0000657)1.75096087
151Furrowed tongue (HP:0000221)1.74166790
152Abnormality of alanine metabolism (HP:0010916)1.71523448
153Hyperalaninemia (HP:0003348)1.71523448
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71523448
155Bile duct proliferation (HP:0001408)1.69614426
156Abnormal biliary tract physiology (HP:0012439)1.69614426
157Genital tract atresia (HP:0001827)1.68508116
158Small hand (HP:0200055)1.67162974
159Renal cortical cysts (HP:0000803)1.66306246
160Cerebellar dysplasia (HP:0007033)1.63537476
161Congenital hepatic fibrosis (HP:0002612)1.63476746
162Abnormal respiratory motile cilium physiology (HP:0012261)1.60559269
163Macroglossia (HP:0000158)1.59527281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.46865095
2EPHA45.98760345
3NTRK34.26875106
4MAP3K93.84406094
5DAPK23.22011042
6BMPR1B2.68820035
7ACVR1B2.65857025
8KSR22.48094798
9MAP3K42.43765409
10PRKD32.40638313
11MINK12.39843398
12PAK62.34606854
13MARK12.17767953
14NTRK22.07319734
15CAMKK12.05071192
16MAP2K71.96909866
17NTRK11.94281879
18ADRBK21.91405400
19WNK31.85347299
20RIPK41.84572914
21GRK11.79882542
22MAP2K41.79868762
23MAP3K131.68798822
24DAPK11.67479066
25TNIK1.64452837
26ARAF1.62245715
27KSR11.58520593
28CDK51.58370514
29MKNK21.47729692
30PRPF4B1.40434081
31STK381.37940966
32MAP4K21.31567600
33FES1.31534695
34TAOK11.31495417
35INSRR1.30062659
36TYRO31.29769803
37MAP3K121.29116382
38MAP3K21.28247870
39SIK21.24610124
40PRKCG1.22393883
41GRK51.20883419
42PINK11.20264218
43CDK191.18893929
44ZAK1.17954329
45NUAK11.14304924
46PLK21.10434271
47STK391.07037473
48TAOK31.05577502
49STK38L1.03685077
50UHMK11.02025522
51SGK4940.97925221
52SGK2230.97925221
53CAMKK20.96706093
54PRKCH0.95234703
55ADRBK10.94918056
56RAF10.94546125
57CAMK10.94166618
58BCR0.93223542
59CASK0.93205672
60STK110.93153049
61CAMK2A0.92483761
62TXK0.91593816
63MAPK130.91578997
64CDK150.88632476
65CDK180.88353582
66WNK40.83274879
67PTK2B0.82983484
68CDK140.82727451
69TRIM280.82105225
70CAMK2B0.79235482
71PNCK0.78134071
72OXSR10.77305405
73PDPK10.76910847
74PHKG20.76672603
75PHKG10.76672603
76CDK11A0.76238286
77SGK20.75827459
78RET0.75587334
79PAK30.75396065
80PDK10.75247731
81MAP3K10.74547976
82SGK30.73502341
83ALK0.73058606
84TGFBR10.72869365
85TNK20.72404990
86LMTK20.71679919
87SGK10.70785177
88LATS20.70641357
89BMPR20.70542436
90STK30.70284110
91MARK20.69200547
92PRKCZ0.62026567
93CSNK1G20.59384147
94MAP3K70.59085558
95PKN10.56670673
96MAPKAPK50.56502958
97DAPK30.54543839
98CAMK2G0.54393925
99NEK60.54368723
100RPS6KA30.53710758
101MKNK10.53679937
102DYRK1A0.53172535
103PIK3CG0.52957166
104MAP2K10.50076156
105NEK10.49820760
106CAMK40.49114077
107PIK3CA0.48350247
108FGFR20.47532021
109RIPK10.47282218
110BRSK10.46551241
111FYN0.45365449
112AKT30.43465614
113ERBB20.41634253
114PRKAA20.41298946
115CAMK2D0.40910297
116MAPK100.39759343
117CSNK1A1L0.39014946
118FGR0.38797895
119PRKCE0.38685209
120ICK0.38295068
121PRKG10.38088252
122CSNK1D0.37849083
123CSNK1G10.37586484
124CDC42BPA0.37054874
125CAMK1G0.36411629
126BRAF0.35648215
127PRKACA0.35626767
128TEC0.33739684
129MAPK120.33510916
130CSNK1A10.32752947
131PRKCA0.32675247
132PRKCB0.31664458
133CSNK1G30.31011634
134MOS0.30489863
135PRKACG0.30334676
136PRKAA10.30073831
137FER0.27721005
138MAP2K60.26948148
139MUSK0.25764718
140MAPKAPK30.24702595
141DYRK20.24101332
142TIE10.24018425

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29936888
2Nitrogen metabolism_Homo sapiens_hsa009103.09008057
3Synaptic vesicle cycle_Homo sapiens_hsa047212.98108568
4Olfactory transduction_Homo sapiens_hsa047402.79551615
5GABAergic synapse_Homo sapiens_hsa047272.63887138
6Circadian entrainment_Homo sapiens_hsa047132.50089607
7Glutamatergic synapse_Homo sapiens_hsa047242.42309199
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36975877
9Morphine addiction_Homo sapiens_hsa050322.36695532
10Long-term potentiation_Homo sapiens_hsa047202.34756529
11Amphetamine addiction_Homo sapiens_hsa050312.29736679
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.29280322
13Salivary secretion_Homo sapiens_hsa049702.00591882
14Dopaminergic synapse_Homo sapiens_hsa047281.91730650
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90693383
16Linoleic acid metabolism_Homo sapiens_hsa005911.84852076
17Insulin secretion_Homo sapiens_hsa049111.82014937
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76173722
19Ether lipid metabolism_Homo sapiens_hsa005651.75651456
20Cholinergic synapse_Homo sapiens_hsa047251.73938054
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70698141
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69144218
23Cocaine addiction_Homo sapiens_hsa050301.68462443
24Gastric acid secretion_Homo sapiens_hsa049711.68320712
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63168503
26ABC transporters_Homo sapiens_hsa020101.53944039
27Renin secretion_Homo sapiens_hsa049241.49724088
28Arginine biosynthesis_Homo sapiens_hsa002201.48761921
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47852368
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.47513956
31Caffeine metabolism_Homo sapiens_hsa002321.45130277
32Oxytocin signaling pathway_Homo sapiens_hsa049211.43852928
33Calcium signaling pathway_Homo sapiens_hsa040201.41609789
34Taste transduction_Homo sapiens_hsa047421.36900752
35Serotonergic synapse_Homo sapiens_hsa047261.32924273
36Propanoate metabolism_Homo sapiens_hsa006401.32285909
37Long-term depression_Homo sapiens_hsa047301.30858964
38Bile secretion_Homo sapiens_hsa049761.28116692
39GnRH signaling pathway_Homo sapiens_hsa049121.21232726
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20487229
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18983282
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18405288
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14037295
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13765755
45cAMP signaling pathway_Homo sapiens_hsa040241.13592694
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13224836
47Butanoate metabolism_Homo sapiens_hsa006501.12925322
48Gap junction_Homo sapiens_hsa045401.09410392
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07729434
50Retinol metabolism_Homo sapiens_hsa008301.07599126
51Histidine metabolism_Homo sapiens_hsa003401.04520794
52Collecting duct acid secretion_Homo sapiens_hsa049661.03670546
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00224098
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00095417
55Type II diabetes mellitus_Homo sapiens_hsa049300.99387862
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97656938
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96672215
58beta-Alanine metabolism_Homo sapiens_hsa004100.91627343
59Glioma_Homo sapiens_hsa052140.89747666
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87399477
61Estrogen signaling pathway_Homo sapiens_hsa049150.86831021
62* Primary bile acid biosynthesis_Homo sapiens_hsa001200.84009502
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83979927
64Chemical carcinogenesis_Homo sapiens_hsa052040.83454676
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81608521
66Melanogenesis_Homo sapiens_hsa049160.80447949
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79349954
68Axon guidance_Homo sapiens_hsa043600.77905478
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.77114888
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76064008
71Homologous recombination_Homo sapiens_hsa034400.74434526
72ErbB signaling pathway_Homo sapiens_hsa040120.74420763
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73881577
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.69336171
75Thyroid hormone synthesis_Homo sapiens_hsa049180.68755298
76Cardiac muscle contraction_Homo sapiens_hsa042600.68292329
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67244795
78Pancreatic secretion_Homo sapiens_hsa049720.64448351
79Selenocompound metabolism_Homo sapiens_hsa004500.63999643
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61877899
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61618488
82Arachidonic acid metabolism_Homo sapiens_hsa005900.61517508
83Fatty acid biosynthesis_Homo sapiens_hsa000610.61363071
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59617023
85Dorso-ventral axis formation_Homo sapiens_hsa043200.58803388
86Glucagon signaling pathway_Homo sapiens_hsa049220.58539016
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58058708
88Vitamin B6 metabolism_Homo sapiens_hsa007500.56483342
89Fanconi anemia pathway_Homo sapiens_hsa034600.55198406
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54415311
91Prion diseases_Homo sapiens_hsa050200.54384951
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.53826662
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53809204
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51408782
95Vibrio cholerae infection_Homo sapiens_hsa051100.51249777
96RNA polymerase_Homo sapiens_hsa030200.49978818
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49795839
98Sphingolipid metabolism_Homo sapiens_hsa006000.49105504
99Oocyte meiosis_Homo sapiens_hsa041140.48901649
100Choline metabolism in cancer_Homo sapiens_hsa052310.48714021
101PPAR signaling pathway_Homo sapiens_hsa033200.48638708
102Fatty acid metabolism_Homo sapiens_hsa012120.47646481
103Dilated cardiomyopathy_Homo sapiens_hsa054140.47129666
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43844923
105MAPK signaling pathway_Homo sapiens_hsa040100.43017918
106Peroxisome_Homo sapiens_hsa041460.42728383
107Phototransduction_Homo sapiens_hsa047440.40551057
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40026406
109Mineral absorption_Homo sapiens_hsa049780.39108407
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39074489
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.39048281
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38723718
113VEGF signaling pathway_Homo sapiens_hsa043700.38316422
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.37955280
115Rap1 signaling pathway_Homo sapiens_hsa040150.36637234
116Circadian rhythm_Homo sapiens_hsa047100.35576029
117Ras signaling pathway_Homo sapiens_hsa040140.34926732
118Regulation of autophagy_Homo sapiens_hsa041400.34517010
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34507112
120Glycerolipid metabolism_Homo sapiens_hsa005610.34479230
121Fatty acid degradation_Homo sapiens_hsa000710.34148055
122Ovarian steroidogenesis_Homo sapiens_hsa049130.33946934
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.33147556
124Lysine degradation_Homo sapiens_hsa003100.32114350
125Tryptophan metabolism_Homo sapiens_hsa003800.30771085
126Complement and coagulation cascades_Homo sapiens_hsa046100.30563008
127African trypanosomiasis_Homo sapiens_hsa051430.30324011
128Type I diabetes mellitus_Homo sapiens_hsa049400.29888157
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29764203
130Alcoholism_Homo sapiens_hsa050340.29431781
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29356363
132Insulin signaling pathway_Homo sapiens_hsa049100.28897396
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.28870733
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.28848729
135Non-small cell lung cancer_Homo sapiens_hsa052230.28637176
136Endocytosis_Homo sapiens_hsa041440.27326023

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