CYP4A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.78285127
2drug catabolic process (GO:0042737)9.33941589
3complement activation, alternative pathway (GO:0006957)8.67023770
4glyoxylate metabolic process (GO:0046487)8.35667882
5* epoxygenase P450 pathway (GO:0019373)8.35609771
6regulation of fibrinolysis (GO:0051917)8.18966143
7L-phenylalanine catabolic process (GO:0006559)8.15441784
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)8.15441784
9* omega-hydroxylase P450 pathway (GO:0097267)8.14016923
10regulation of protein activation cascade (GO:2000257)7.73298849
11negative regulation of fibrinolysis (GO:0051918)7.50475350
12ethanol oxidation (GO:0006069)7.44448259
13L-phenylalanine metabolic process (GO:0006558)7.38335847
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.38335847
15regulation of complement activation (GO:0030449)7.38239613
16urea metabolic process (GO:0019627)6.57603838
17drug metabolic process (GO:0017144)6.56890544
18protein carboxylation (GO:0018214)6.53028662
19peptidyl-glutamic acid carboxylation (GO:0017187)6.53028662
20fibrinolysis (GO:0042730)6.34211505
21oxidative demethylation (GO:0070989)6.19648486
22aromatic amino acid family catabolic process (GO:0009074)6.16665779
23negative regulation of cholesterol transport (GO:0032375)6.11030295
24negative regulation of sterol transport (GO:0032372)6.11030295
25serine family amino acid catabolic process (GO:0009071)6.07424175
26ethanol metabolic process (GO:0006067)5.98130051
27nitrogen cycle metabolic process (GO:0071941)5.97483989
28blood coagulation, intrinsic pathway (GO:0007597)5.96078290
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.90703935
30imidazole-containing compound metabolic process (GO:0052803)5.85657048
31bile acid biosynthetic process (GO:0006699)5.68974179
32urea cycle (GO:0000050)5.65600903
33regulation of triglyceride catabolic process (GO:0010896)5.56152205
34cellular glucuronidation (GO:0052695)5.49748297
35regulation of plasminogen activation (GO:0010755)5.49158584
36protein activation cascade (GO:0072376)5.31969687
37phenylpropanoid metabolic process (GO:0009698)5.31175610
38glucuronate metabolic process (GO:0019585)5.23247063
39uronic acid metabolic process (GO:0006063)5.23247063
40glycine metabolic process (GO:0006544)5.20755195
41complement activation (GO:0006956)5.09614735
42S-adenosylmethionine metabolic process (GO:0046500)5.02836673
43bile acid metabolic process (GO:0008206)5.02108322
44complement activation, classical pathway (GO:0006958)5.01278589
45opsonization (GO:0008228)5.00259282
46tyrosine metabolic process (GO:0006570)4.95236786
47negative regulation of hemostasis (GO:1900047)4.73854970
48negative regulation of blood coagulation (GO:0030195)4.73854970
49regulation of humoral immune response (GO:0002920)4.69073955
50glutamate metabolic process (GO:0006536)4.57856737
51bile acid and bile salt transport (GO:0015721)4.57659561
52acute-phase response (GO:0006953)4.52752576
53triglyceride homeostasis (GO:0070328)4.51206047
54acylglycerol homeostasis (GO:0055090)4.51206047
55positive regulation of lipoprotein lipase activity (GO:0051006)4.47891745
56positive regulation of triglyceride lipase activity (GO:0061365)4.47891745
57negative regulation of protein activation cascade (GO:2000258)4.45950649
58phospholipid efflux (GO:0033700)4.41163924
59indole-containing compound catabolic process (GO:0042436)4.39975996
60indolalkylamine catabolic process (GO:0046218)4.39975996
61tryptophan catabolic process (GO:0006569)4.39975996
62cytolysis (GO:0019835)4.37922217
63alkaloid metabolic process (GO:0009820)4.37030040
64plasma lipoprotein particle remodeling (GO:0034369)4.34697138
65protein-lipid complex remodeling (GO:0034368)4.34697138
66macromolecular complex remodeling (GO:0034367)4.34697138
67alpha-amino acid catabolic process (GO:1901606)4.30554438
68disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.29995793
69killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.29995793
70negative regulation of coagulation (GO:0050819)4.29820762
71response to mercury ion (GO:0046689)4.24965541
72negative regulation of wound healing (GO:0061045)4.23759366
73cellular ketone body metabolic process (GO:0046950)4.22185450
74amino-acid betaine metabolic process (GO:0006577)4.21392600
75cholesterol efflux (GO:0033344)4.19455681
76high-density lipoprotein particle remodeling (GO:0034375)4.17748437
77serine family amino acid metabolic process (GO:0009069)4.15044557
78positive regulation of blood coagulation (GO:0030194)4.11115714
79positive regulation of hemostasis (GO:1900048)4.11115714
80aromatic amino acid family metabolic process (GO:0009072)4.06951015
81arginine metabolic process (GO:0006525)4.01448626
82flavonoid metabolic process (GO:0009812)3.92074246
83reverse cholesterol transport (GO:0043691)3.88703648
84positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.81888757
85negative regulation of lipase activity (GO:0060192)3.80680877
86positive regulation of coagulation (GO:0050820)3.77367723
87tryptophan metabolic process (GO:0006568)3.74131385
88regulation of cholesterol esterification (GO:0010872)3.73176848
89intestinal cholesterol absorption (GO:0030299)3.72365145
90negative regulation of complement activation (GO:0045916)3.70493529
91ketone body metabolic process (GO:1902224)3.70464908
92cellular amino acid catabolic process (GO:0009063)3.68260618
93serine family amino acid biosynthetic process (GO:0009070)3.65210735
94sodium-independent organic anion transport (GO:0043252)3.59868367
95cysteine metabolic process (GO:0006534)3.51792960
96positive regulation of lipid catabolic process (GO:0050996)3.46673086
97hormone catabolic process (GO:0042447)3.45626727
98* xenobiotic metabolic process (GO:0006805)3.45371636
99acute inflammatory response (GO:0002526)3.44640234
100heme transport (GO:0015886)3.41052372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse6.91286805
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.83596823
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.64887364
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.63428732
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.40585200
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.51436906
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.41367588
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.89503826
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.74775979
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46436485
11HTT_18923047_ChIP-ChIP_STHdh_Human2.11055058
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06475238
13* HNF4A_19822575_ChIP-Seq_HepG2_Human2.00071000
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9878781
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.96196763
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83863454
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82928953
18BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44731322
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30611840
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22512593
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.19236505
22BCAT_22108803_ChIP-Seq_LS180_Human1.16095222
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14003449
24AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11810073
25PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10954027
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09069274
27IRF1_19129219_ChIP-ChIP_H3396_Human1.01696669
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01575602
29IRF8_22096565_ChIP-ChIP_GC-B_Human0.98507866
30PIAS1_25552417_ChIP-Seq_VCAP_Human0.93472793
31CBP_21632823_ChIP-Seq_H3396_Human0.89852699
32AR_20517297_ChIP-Seq_VCAP_Human0.89565460
33RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88909964
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87972220
35POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87526679
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85001404
37* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84670932
38GATA1_22025678_ChIP-Seq_K562_Human0.83834874
39TP53_18474530_ChIP-ChIP_U2OS_Human0.81674298
40NFE2_27457419_Chip-Seq_LIVER_Mouse0.81540017
41TRIM28_21343339_ChIP-Seq_HEK293_Human0.80514617
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79760051
43* PHF8_20622853_ChIP-Seq_HELA_Human0.79026751
44* HNFA_21074721_ChIP-Seq_CACO-2_Human0.78817621
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78683800
46ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78623215
47CEBPB_22108803_ChIP-Seq_LS180_Human0.78501405
48GATA4_25053715_ChIP-Seq_YYC3_Human0.75984999
49KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73947261
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73184470
51EZH2_27294783_Chip-Seq_NPCs_Mouse0.73161846
52ER_23166858_ChIP-Seq_MCF-7_Human0.72907805
53SOX2_21211035_ChIP-Seq_LN229_Human0.71526919
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71121365
55* NFYA_21822215_ChIP-Seq_K562_Human0.70801051
56MYC_19829295_ChIP-Seq_ESCs_Human0.70252610
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69489511
58GBX2_23144817_ChIP-Seq_PC3_Human0.69173661
59FOXA1_25552417_ChIP-Seq_VCAP_Human0.68958166
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68707315
61P53_21459846_ChIP-Seq_SAOS-2_Human0.67485094
62CDX2_22108803_ChIP-Seq_LS180_Human0.66588826
63* RAC3_21632823_ChIP-Seq_H3396_Human0.66577931
64* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.65606907
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.63512195
66CRX_20693478_ChIP-Seq_RETINA_Mouse0.62444322
67CDX2_20551321_ChIP-Seq_CACO-2_Human0.61802732
68TAF2_19829295_ChIP-Seq_ESCs_Human0.61685360
69FOXH1_21741376_ChIP-Seq_EPCs_Human0.61153960
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61067263
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60797808
72SUZ12_27294783_Chip-Seq_NPCs_Mouse0.60721699
73SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.60647860
74* GATA6_21074721_ChIP-Seq_CACO-2_Human0.60502674
75ERG_20517297_ChIP-Seq_VCAP_Human0.60493580
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.60193973
77* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.59901006
78KLF5_20875108_ChIP-Seq_MESCs_Mouse0.59434683
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.59251530
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58393057
81* ETV1_20927104_ChIP-Seq_GIST48_Human0.58055913
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.57657156
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.57472769
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.57012672
85OCT4_21477851_ChIP-Seq_ESCs_Mouse0.54877478
86DROSHA_22980978_ChIP-Seq_HELA_Human0.54741455
87P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.54364665
88NANOG_19829295_ChIP-Seq_ESCs_Human0.54161873
89SOX2_19829295_ChIP-Seq_ESCs_Human0.54161873
90RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53854990
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.53671147
92CBP_20019798_ChIP-Seq_JUKART_Human0.53671147
93TCF4_22108803_ChIP-Seq_LS180_Human0.53258751
94NCOR_22424771_ChIP-Seq_293T_Human0.52900650
95SPI1_20517297_ChIP-Seq_HL60_Human0.52810326
96OCT4_18555785_Chip-Seq_ESCs_Mouse0.52320061
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.52313785
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.52285506
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.51841111
100* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.51426136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.32585763
2MP0005360_urolithiasis6.60394939
3MP0005085_abnormal_gallbladder_physiolo6.21342499
4MP0003195_calcinosis6.10364164
5MP0008875_abnormal_xenobiotic_pharmacok5.88207729
6MP0005365_abnormal_bile_salt5.40224502
7MP0002138_abnormal_hepatobiliary_system4.46845552
8MP0003252_abnormal_bile_duct4.07607122
9MP0001666_abnormal_nutrient_absorption3.02302277
10MP0010329_abnormal_lipoprotein_level2.87902465
11MP0003868_abnormal_feces_composition2.72493105
12MP0005332_abnormal_amino_acid2.63086734
13MP0009697_abnormal_copulation2.53430385
14MP0003191_abnormal_cellular_cholesterol2.26765542
15MP0003806_abnormal_nucleotide_metabolis2.23515096
16MP0010368_abnormal_lymphatic_system2.02299832
17MP0002876_abnormal_thyroid_physiology1.82754334
18MP0009840_abnormal_foam_cell1.81638140
19MP0000609_abnormal_liver_physiology1.78823225
20MP0002118_abnormal_lipid_homeostasis1.67424301
21MP0001764_abnormal_homeostasis1.59965463
22MP0004019_abnormal_vitamin_homeostasis1.47584573
23MP0005670_abnormal_white_adipose1.47492447
24MP0009053_abnormal_anal_canal1.24349349
25MP0009643_abnormal_urine_homeostasis1.21331664
26MP0001661_extended_life_span1.15697462
27MP0005319_abnormal_enzyme/_coenzyme1.14269780
28MP0002132_abnormal_respiratory_system1.11385330
29MP0003656_abnormal_erythrocyte_physiolo1.11365104
30MP0009764_decreased_sensitivity_to1.09323428
31MP0005408_hypopigmentation1.00868669
32MP0000598_abnormal_liver_morphology1.00825763
33MP0008872_abnormal_physiological_respon0.98997806
34MP0005584_abnormal_enzyme/coenzyme_acti0.98519197
35MP0002971_abnormal_brown_adipose0.93417104
36MP0002168_other_aberrant_phenotype0.91420937
37MP0005636_abnormal_mineral_homeostasis0.90357681
38MP0002282_abnormal_trachea_morphology0.88880861
39MP0004043_abnormal_pH_regulation0.87828576
40MP0009642_abnormal_blood_homeostasis0.83392011
41MP0005395_other_phenotype0.83117702
42MP0009763_increased_sensitivity_to0.82938213
43MP0003879_abnormal_hair_cell0.81283835
44MP0005376_homeostasis/metabolism_phenot0.80536281
45MP0005451_abnormal_body_composition0.79840412
46MP0003186_abnormal_redox_activity0.79494431
47MP0008469_abnormal_protein_level0.74692813
48MP0000604_amyloidosis0.74159540
49MP0002249_abnormal_larynx_morphology0.73481036
50MP0005535_abnormal_body_temperature0.72846354
51MP0003690_abnormal_glial_cell0.66023716
52MP0003011_delayed_dark_adaptation0.63995234
53MP0005266_abnormal_metabolism0.62682782
54MP0005187_abnormal_penis_morphology0.61571364
55MP0001756_abnormal_urination0.61516736
56MP0001915_intracranial_hemorrhage0.61336128
57MP0002078_abnormal_glucose_homeostasis0.61300261
58MP0005334_abnormal_fat_pad0.60772174
59MP0004130_abnormal_muscle_cell0.59993982
60MP0008874_decreased_physiological_sensi0.58775280
61MP0002136_abnormal_kidney_physiology0.50783488
62MP0005083_abnormal_biliary_tract0.49954108
63MP0004782_abnormal_surfactant_physiolog0.49612850
64MP0003638_abnormal_response/metabolism_0.47269709
65MP0005464_abnormal_platelet_physiology0.47020457
66MP0009785_altered_susceptibility_to0.45655078
67MP0005166_decreased_susceptibility_to0.45324790
68MP0009765_abnormal_xenobiotic_induced0.45242793
69MP0002928_abnormal_bile_duct0.43258624
70MP0005448_abnormal_energy_balance0.40852337
71MP0006036_abnormal_mitochondrial_physio0.40458924
72MP0000249_abnormal_blood_vessel0.38939857
73MP0003075_altered_response_to0.38350950
74MP0000467_abnormal_esophagus_morphology0.37790898
75MP0004883_abnormal_blood_vessel0.37704563
76MP0005023_abnormal_wound_healing0.36615609
77MP0002332_abnormal_exercise_endurance0.36570499
78MP0000566_synostosis0.35925604
79MP0005220_abnormal_exocrine_pancreas0.34476303
80MP0003953_abnormal_hormone_level0.32249379
81MP0001986_abnormal_taste_sensitivity0.32175949
82MP0001545_abnormal_hematopoietic_system0.32110043
83MP0005397_hematopoietic_system_phenotyp0.32110043
84MP0005164_abnormal_response_to0.30376425
85MP0005084_abnormal_gallbladder_morpholo0.28665699
86MP0000639_abnormal_adrenal_gland0.26279833
87MP0009115_abnormal_fat_cell0.25245050
88MP0005647_abnormal_sex_gland0.24920717
89MP0005058_abnormal_lysosome_morphology0.21754417
90MP0005646_abnormal_pituitary_gland0.21595732
91MP0003718_maternal_effect0.21404672
92MP0006292_abnormal_olfactory_placode0.20160862
93MP0001851_eye_inflammation0.19587161
94MP0001944_abnormal_pancreas_morphology0.19432928
95MP0002135_abnormal_kidney_morphology0.18338460
96MP0003705_abnormal_hypodermis_morpholog0.18333320
97MP0001845_abnormal_inflammatory_respons0.18290031
98MP0005666_abnormal_adipose_tissue0.17784949
99MP0002970_abnormal_white_adipose0.17326153
100MP0005377_hearing/vestibular/ear_phenot0.17289896

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.40749062
2Prolonged partial thromboplastin time (HP:0003645)9.11632207
3Abnormality of aromatic amino acid family metabolism (HP:0004338)8.48075232
4Abnormality of complement system (HP:0005339)8.07865339
5Hypobetalipoproteinemia (HP:0003563)7.03749358
6Systemic lupus erythematosus (HP:0002725)6.51730741
7Joint hemorrhage (HP:0005261)6.50342784
8Conjugated hyperbilirubinemia (HP:0002908)6.47972360
9Hyperlipoproteinemia (HP:0010980)5.84032054
10Xanthomatosis (HP:0000991)5.21449136
11Glomerulonephritis (HP:0000099)5.06874109
12Abnormality of pyrimidine metabolism (HP:0004353)5.04456470
13Intrahepatic cholestasis (HP:0001406)4.92494979
14Recurrent gram-negative bacterial infections (HP:0005420)4.82379240
15Spontaneous abortion (HP:0005268)4.25848455
16Abnormality of the intrinsic pathway (HP:0010989)4.25356291
17Hypolipoproteinemia (HP:0010981)4.16603811
18Abnormality of the common coagulation pathway (HP:0010990)4.09240938
19Nephritis (HP:0000123)3.85778338
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.76384713
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.70198547
22Abnormality of methionine metabolism (HP:0010901)3.63062312
23Hyperglycinemia (HP:0002154)3.46231343
24Hypoalphalipoproteinemia (HP:0003233)3.39515675
25Generalized aminoaciduria (HP:0002909)3.26989853
26Delayed CNS myelination (HP:0002188)3.20854615
27Abnormality of glycine metabolism (HP:0010895)3.11848216
28Abnormality of serine family amino acid metabolism (HP:0010894)3.11848216
29Hyperammonemia (HP:0001987)3.05652637
30Fair hair (HP:0002286)2.95716981
31Abnormality of nucleobase metabolism (HP:0010932)2.94852641
32Neonatal hypoglycemia (HP:0001998)2.94762823
33Fat malabsorption (HP:0002630)2.92119374
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.88700734
35Hypercholesterolemia (HP:0003124)2.86923969
36Gingival bleeding (HP:0000225)2.80133580
37Epidermoid cyst (HP:0200040)2.79630863
38Mitral stenosis (HP:0001718)2.78631995
39Vascular calcification (HP:0004934)2.76019996
40Rickets (HP:0002748)2.67188252
41Abnormality of serum amino acid levels (HP:0003112)2.66215476
42Abnormality of sulfur amino acid metabolism (HP:0004339)2.63801542
43Hyperglycinuria (HP:0003108)2.63263509
44Hemorrhage of the eye (HP:0011885)2.63142730
45Thrombophlebitis (HP:0004418)2.62327183
46Osteomalacia (HP:0002749)2.52082649
47Hyperbilirubinemia (HP:0002904)2.50241449
48Alkalosis (HP:0001948)2.44978909
49Cardiovascular calcification (HP:0011915)2.43241927
50Purpura (HP:0000979)2.42593819
51Hepatocellular carcinoma (HP:0001402)2.33253187
52Pulmonary embolism (HP:0002204)2.32696121
53Menorrhagia (HP:0000132)2.29241337
54Steatorrhea (HP:0002570)2.27946358
55Ketosis (HP:0001946)2.20301348
56Hyperphosphaturia (HP:0003109)2.20106794
57Gout (HP:0001997)2.19283378
58Metabolic acidosis (HP:0001942)2.18933662
59Generalized hypopigmentation of hair (HP:0011358)2.06701554
60Abnormality of monocarboxylic acid metabolism (HP:0010996)10.0969094
61Complement deficiency (HP:0004431)10.0704844
62Abnormality of purine metabolism (HP:0004352)1.98784220
63Cholelithiasis (HP:0001081)1.97611241
64Abnormality of urine glucose concentration (HP:0011016)1.96885966
65Glycosuria (HP:0003076)1.96885966
66Reduced antithrombin III activity (HP:0001976)1.94083375
67Elevated alkaline phosphatase (HP:0003155)1.93598937
68Irritability (HP:0000737)1.93342953
69Arthropathy (HP:0003040)1.89151166
70Abnormality of vitamin metabolism (HP:0100508)1.88345025
71Myocardial infarction (HP:0001658)1.86709387
72Abnormal gallbladder morphology (HP:0012437)1.86013913
73Blue irides (HP:0000635)1.84138172
74Hypophosphatemic rickets (HP:0004912)1.82754496
75Abnormal enzyme/coenzyme activity (HP:0012379)1.81840455
76Gangrene (HP:0100758)1.78661407
77Abnormality of alkaline phosphatase activity (HP:0004379)1.77358881
78Joint swelling (HP:0001386)1.77355831
79Impaired platelet aggregation (HP:0003540)1.76896657
80Abnormal platelet function (HP:0011869)1.76896657
81Cholecystitis (HP:0001082)1.75971993
82Abnormal gallbladder physiology (HP:0012438)1.75971993
83Abnormal urine phosphate concentration (HP:0012599)1.75355650
84Increased mean platelet volume (HP:0011877)1.74034454
85Enlarged kidneys (HP:0000105)1.73271058
86Abnormality of the Achilles tendon (HP:0005109)1.72359349
87Abnormality of proline metabolism (HP:0010907)1.71963975
88Hydroxyprolinuria (HP:0003080)1.71963975
89Abnormality of iron homeostasis (HP:0011031)1.71596771
90Cerebral palsy (HP:0100021)1.69212597
91Proximal tubulopathy (HP:0000114)1.64790478
92Increased serum ferritin (HP:0003281)1.64762429
93Bifid scrotum (HP:0000048)1.64046676
94Epistaxis (HP:0000421)1.64038193
95Poikilocytosis (HP:0004447)1.62922536
96Hypochromic microcytic anemia (HP:0004840)1.61836942
97Atrioventricular block (HP:0001678)1.61613677
98Skin nodule (HP:0200036)1.61200260
99Lethargy (HP:0001254)1.58404595
100Neonatal onset (HP:0003623)1.57794268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.72735968
2ERN15.26900242
3OXSR13.29822687
4FGFR42.96139730
5BCKDK2.74143380
6PIK3CG2.63882859
7FRK2.60968926
8SIK12.39139924
9PIK3CA2.19997418
10TRIB32.19357516
11PRKACG2.15061204
12RIPK11.91229154
13NTRK31.90366083
14TYK21.88415114
15PRKAA21.85458049
16SGK21.68424145
17TIE11.67109292
18PRKCG1.66181254
19MAPK111.65251138
20EPHA31.63447184
21TAOK31.62754746
22INSRR1.52285673
23EPHA41.51550686
24SGK2231.49161128
25SGK4941.49161128
26WNK41.40178526
27MAP2K41.39905606
28TNK21.27890648
29SGK31.24455261
30IGF1R1.17350291
31MAP3K31.14523218
32PINK11.10048946
33ERBB21.03831135
34PRKAA11.01304151
35PRKACA1.00534287
36CAMKK20.98883462
37NLK0.98749897
38ADRBK20.97495712
39PRKCZ0.96438982
40DYRK1B0.95128087
41FER0.92900737
42PDPK10.91988924
43PRKG10.91311263
44JAK10.90598255
45FGFR30.87558566
46KDR0.84927090
47NEK90.84602321
48CSF1R0.84231644
49PRPF4B0.78508909
50MAPK70.74783043
51DAPK20.73225296
52FGFR20.72895923
53ABL20.71230806
54MAPKAPK30.70782898
55MAPK120.70498852
56TGFBR20.69049561
57MST1R0.68074931
58PKN20.66664800
59PDK10.66087359
60GRK10.66043495
61PRKCB0.62825606
62LATS10.62185713
63STK390.61902965
64PRKCA0.61775888
65CSNK1D0.60563918
66SGK10.60197608
67JAK20.59203207
68RPS6KA30.58093073
69AKT30.55927875
70MAPK40.54494094
71PRKACB0.52978267
72MAP4K20.52869958
73CSNK1A10.52712759
74STK380.52174649
75EPHB10.50797233
76STK38L0.48678098
77CDK60.47772597
78BLK0.44141658
79GSK3A0.43221621
80KIT0.42580993
81PRKCE0.41304329
82MYLK0.40827911
83BCR0.40616903
84TBK10.39857160
85MAP3K20.39832797
86SRC0.38945755
87CSNK1E0.38363103
88PDK20.38224773
89RET0.35376552
90DYRK1A0.34897643
91CAMKK10.32666931
92BRSK20.30530727
93CAMK40.30328022
94CSNK2A10.29030928
95MAP3K10.28889034
96TNIK0.28103950
97MAPK30.28070818
98CASK0.27626553
99PAK30.26791653
100MAP3K70.25015843

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.47339552
2Caffeine metabolism_Homo sapiens_hsa002324.33641780
3Complement and coagulation cascades_Homo sapiens_hsa046103.94819300
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.74525821
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.47742638
6* Retinol metabolism_Homo sapiens_hsa008303.29274092
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.21046687
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.93448813
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.87789069
10Chemical carcinogenesis_Homo sapiens_hsa052042.87557341
11Arginine biosynthesis_Homo sapiens_hsa002202.69488628
12Phenylalanine metabolism_Homo sapiens_hsa003602.56724893
13Tyrosine metabolism_Homo sapiens_hsa003502.50695864
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.48506619
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.47328924
16* Fatty acid degradation_Homo sapiens_hsa000712.44449960
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.34022747
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.23304938
19Histidine metabolism_Homo sapiens_hsa003402.16308501
20Butanoate metabolism_Homo sapiens_hsa006501.99273401
21Tryptophan metabolism_Homo sapiens_hsa003801.88716739
22Linoleic acid metabolism_Homo sapiens_hsa005911.82269750
23Bile secretion_Homo sapiens_hsa049761.69936697
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60400474
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.57803191
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55192542
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52181608
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.44333355
29Starch and sucrose metabolism_Homo sapiens_hsa005001.42419681
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.40260394
31Staphylococcus aureus infection_Homo sapiens_hsa051501.34345615
32PPAR signaling pathway_Homo sapiens_hsa033201.34340078
33beta-Alanine metabolism_Homo sapiens_hsa004101.31475617
34Prion diseases_Homo sapiens_hsa050201.30672953
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30477927
36Peroxisome_Homo sapiens_hsa041461.21336066
37Biosynthesis of amino acids_Homo sapiens_hsa012301.16735063
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10540348
39Vitamin B6 metabolism_Homo sapiens_hsa007501.05044756
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02279601
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01759363
42Pyruvate metabolism_Homo sapiens_hsa006201.01475704
43* Arachidonic acid metabolism_Homo sapiens_hsa005900.99459447
44Arginine and proline metabolism_Homo sapiens_hsa003300.96386217
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89797771
46One carbon pool by folate_Homo sapiens_hsa006700.88714420
47Propanoate metabolism_Homo sapiens_hsa006400.88301870
48Carbon metabolism_Homo sapiens_hsa012000.84092330
49ABC transporters_Homo sapiens_hsa020100.82065572
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79140617
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73231071
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.70174320
53Fat digestion and absorption_Homo sapiens_hsa049750.70002800
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63836953
55Fatty acid metabolism_Homo sapiens_hsa012120.62615551
56Sulfur relay system_Homo sapiens_hsa041220.44919303
57Lysine degradation_Homo sapiens_hsa003100.44901634
58Sulfur metabolism_Homo sapiens_hsa009200.42954867
59* Metabolic pathways_Homo sapiens_hsa011000.42844971
60Pertussis_Homo sapiens_hsa051330.31836165
61Glycerolipid metabolism_Homo sapiens_hsa005610.30481360
62Insulin resistance_Homo sapiens_hsa049310.26166520
63Glucagon signaling pathway_Homo sapiens_hsa049220.23563957
64Fructose and mannose metabolism_Homo sapiens_hsa000510.21118981
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20214660
66Pentose phosphate pathway_Homo sapiens_hsa000300.16559122
67Systemic lupus erythematosus_Homo sapiens_hsa053220.15349632
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10164116
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.08856671
70Fatty acid elongation_Homo sapiens_hsa000620.07163691
71Vitamin digestion and absorption_Homo sapiens_hsa049770.05712086
72AMPK signaling pathway_Homo sapiens_hsa041520.03804333
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.03172210
74Serotonergic synapse_Homo sapiens_hsa047260.02939329
75Mineral absorption_Homo sapiens_hsa049780.01869835
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01180790
77Glutathione metabolism_Homo sapiens_hsa004800.01016784
78Selenocompound metabolism_Homo sapiens_hsa004500.00712849
79* Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2776949
80Ether lipid metabolism_Homo sapiens_hsa00565-0.2730878
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2605928
82Type II diabetes mellitus_Homo sapiens_hsa04930-0.2471854
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.2449514
84Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2219716
85Sphingolipid metabolism_Homo sapiens_hsa00600-0.2120637
86GABAergic synapse_Homo sapiens_hsa04727-0.2105649
87Circadian rhythm_Homo sapiens_hsa04710-0.1704190
88Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1630225
89Insulin signaling pathway_Homo sapiens_hsa04910-0.1585109
90Other glycan degradation_Homo sapiens_hsa00511-0.1554567
91Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1491084
92African trypanosomiasis_Homo sapiens_hsa05143-0.0967642
93Steroid biosynthesis_Homo sapiens_hsa00100-0.0830915
94Nitrogen metabolism_Homo sapiens_hsa00910-0.0805781
95Folate biosynthesis_Homo sapiens_hsa00790-0.0800573
96Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0770108
97Renin-angiotensin system_Homo sapiens_hsa04614-0.0671398
98Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0608112
99Galactose metabolism_Homo sapiens_hsa00052-0.0566651
100Amoebiasis_Homo sapiens_hsa05146-0.0131917

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