CYP4B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.90684636
2axoneme assembly (GO:0035082)9.69613240
3aminoglycoside antibiotic metabolic process (GO:0030647)9.41751635
4left/right pattern formation (GO:0060972)8.58702124
5primary alcohol catabolic process (GO:0034310)8.24325408
6drug transport (GO:0015893)8.15439043
7phosphate ion transport (GO:0006817)7.85002003
8organic cation transport (GO:0015695)7.44843321
9regulation of cilium movement (GO:0003352)7.27126967
10ethanol metabolic process (GO:0006067)7.03571638
11lysine catabolic process (GO:0006554)7.03010814
12lysine metabolic process (GO:0006553)7.03010814
13vitamin transmembrane transport (GO:0035461)6.80276115
14phosphate ion transmembrane transport (GO:0035435)6.68336592
15glyoxylate metabolic process (GO:0046487)6.53541822
16left/right axis specification (GO:0070986)6.51306028
17quaternary ammonium group transport (GO:0015697)6.42413150
18one-carbon compound transport (GO:0019755)6.22971481
19cysteine metabolic process (GO:0006534)6.19001652
20diterpenoid biosynthetic process (GO:0016102)6.01515824
21microtubule bundle formation (GO:0001578)6.00481269
22ventricular system development (GO:0021591)5.99586809
23intraciliary transport (GO:0042073)5.77640207
24response to mercury ion (GO:0046689)5.69368016
25tricarboxylic acid metabolic process (GO:0072350)5.58248407
26cilium organization (GO:0044782)5.50791031
27cilium assembly (GO:0042384)5.33574168
28pyrimidine-containing compound transmembrane transport (GO:0072531)5.30446983
29nonribosomal peptide biosynthetic process (GO:0019184)5.29305238
30negative regulation of humoral immune response (GO:0002921)5.24719297
31response to xenobiotic stimulus (GO:0009410)5.23071790
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.21434486
33trivalent inorganic anion homeostasis (GO:0072506)5.20688029
34phosphate ion homeostasis (GO:0055062)5.20688029
35short-chain fatty acid metabolic process (GO:0046459)5.17261393
36renal absorption (GO:0070293)5.10203247
37excretion (GO:0007588)5.05918231
38vitamin D metabolic process (GO:0042359)5.04287681
39lung epithelium development (GO:0060428)4.94054756
40tolerance induction (GO:0002507)4.86404545
41branched-chain amino acid metabolic process (GO:0009081)4.85676188
42homocysteine metabolic process (GO:0050667)4.78844265
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.77447012
44L-phenylalanine metabolic process (GO:0006558)4.77447012
45toxin transport (GO:1901998)4.76962690
46glutathione biosynthetic process (GO:0006750)4.75706370
47aspartate family amino acid catabolic process (GO:0009068)4.74011060
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.70146315
49L-phenylalanine catabolic process (GO:0006559)4.70146315
50amino-acid betaine transport (GO:0015838)4.69145988
51carnitine transport (GO:0015879)4.69145988
52negative regulation of B cell mediated immunity (GO:0002713)4.62858654
53negative regulation of immunoglobulin mediated immune response (GO:0002890)4.62858654
54protein localization to cilium (GO:0061512)4.62275396
55centriole assembly (GO:0098534)4.58614567
56valine metabolic process (GO:0006573)4.53580009
57fatty acid beta-oxidation (GO:0006635)4.44443082
58establishment of apical/basal cell polarity (GO:0035089)4.44255061
59glomerular epithelial cell development (GO:0072310)4.42889770
60metanephric nephron tubule development (GO:0072234)4.42718761
61metanephric tubule development (GO:0072170)4.42718761
62negative regulation of T cell differentiation in thymus (GO:0033085)4.40479906
63regulation of interleukin-5 production (GO:0032674)4.39040505
64regulation of germinal center formation (GO:0002634)4.37674368
65serine family amino acid catabolic process (GO:0009071)4.37463947
66peptide catabolic process (GO:0043171)4.33226924
67amino-acid betaine metabolic process (GO:0006577)4.28024837
68cellular modified amino acid catabolic process (GO:0042219)4.27601349
69cellular component assembly involved in morphogenesis (GO:0010927)4.27153549
70sodium-independent organic anion transport (GO:0043252)4.27131217
71regulation of microtubule-based movement (GO:0060632)4.23993076
72terpenoid biosynthetic process (GO:0016114)4.21112950
73aromatic amino acid family catabolic process (GO:0009074)4.20274098
74serine family amino acid metabolic process (GO:0009069)4.18906566
75surfactant homeostasis (GO:0043129)4.18651539
76metanephric nephron epithelium development (GO:0072243)4.18100587
77sperm capacitation (GO:0048240)4.17390117
78retinoic acid metabolic process (GO:0042573)4.16356784
79glycoside metabolic process (GO:0016137)4.14821716
80microtubule-based movement (GO:0007018)4.11582664
81negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.11337944
82fatty acid oxidation (GO:0019395)4.11337328
83positive regulation of tolerance induction (GO:0002645)4.09964750
84proline metabolic process (GO:0006560)4.09705131
85lipid oxidation (GO:0034440)4.03064169
86branched-chain amino acid catabolic process (GO:0009083)3.97781385
87regulation of interleukin-13 production (GO:0032656)3.97370878
88cilium morphogenesis (GO:0060271)3.95864224
89cell projection assembly (GO:0030031)3.94894417
90carnitine metabolic process (GO:0009437)3.93813425
91modified amino acid transport (GO:0072337)3.88093202
92establishment of monopolar cell polarity (GO:0061162)3.85351398
93establishment or maintenance of monopolar cell polarity (GO:0061339)3.85351398
94fructose metabolic process (GO:0006000)3.83672421
95metanephric epithelium development (GO:0072207)3.83014316
96primary alcohol metabolic process (GO:0034308)3.82057360
97tryptophan catabolic process (GO:0006569)3.80459693
98indole-containing compound catabolic process (GO:0042436)3.80459693
99indolalkylamine catabolic process (GO:0046218)3.80459693
100peptide biosynthetic process (GO:0043043)3.77318681
101cellular ketone body metabolic process (GO:0046950)3.76683577
102cytoplasmic microtubule organization (GO:0031122)3.75640089
1032-oxoglutarate metabolic process (GO:0006103)3.74005794
104fatty acid catabolic process (GO:0009062)3.69252122
105tryptophan metabolic process (GO:0006568)3.66959613
106sulfur amino acid catabolic process (GO:0000098)3.65357009
107hydrogen peroxide biosynthetic process (GO:0050665)3.63611483
108response to phenylpropanoid (GO:0080184)3.63321115
109nephron tubule development (GO:0072080)3.62638945
110glutathione metabolic process (GO:0006749)3.62473258
111response to growth hormone (GO:0060416)3.62370435
112acetyl-CoA metabolic process (GO:0006084)3.61932863
113retinol metabolic process (GO:0042572)3.57478239
114NADH metabolic process (GO:0006734)3.54258167
115nucleoside diphosphate phosphorylation (GO:0006165)3.48842977
116cellular amino acid catabolic process (GO:0009063)3.47870189
117beta-amyloid metabolic process (GO:0050435)3.47610273
118monocarboxylic acid catabolic process (GO:0072329)3.43279114
119establishment of planar polarity (GO:0001736)3.41529290
120establishment of tissue polarity (GO:0007164)3.41529290
121glutathione derivative metabolic process (GO:1901685)3.41225907
122glutathione derivative biosynthetic process (GO:1901687)3.41225907
123oligosaccharide catabolic process (GO:0009313)3.37407702
124multicellular organismal water homeostasis (GO:0050891)3.36244398
125flavonoid metabolic process (GO:0009812)3.35262660
126lateral ventricle development (GO:0021670)3.34957653
127alpha-amino acid catabolic process (GO:1901606)3.33916260
128NADP metabolic process (GO:0006739)3.33168928
129serine family amino acid biosynthetic process (GO:0009070)3.31214810
130organic acid catabolic process (GO:0016054)3.28266656
131carboxylic acid catabolic process (GO:0046395)3.28266656
132response to parathyroid hormone (GO:0071107)3.25476864
133ethanol oxidation (GO:0006069)3.23324139
134renal tubule development (GO:0061326)3.23291480
135ketone body metabolic process (GO:1902224)3.22170185
136O-glycan processing (GO:0016266)3.21967512
137reactive oxygen species biosynthetic process (GO:1903409)3.21084552
138glutamate metabolic process (GO:0006536)3.19818965
139chemical homeostasis within a tissue (GO:0048875)3.18262819
140vitamin transport (GO:0051180)3.14325128
141aromatic amino acid family metabolic process (GO:0009072)3.08812250
142negative regulation of inclusion body assembly (GO:0090084)3.06244922
143regulation of cholesterol homeostasis (GO:2000188)3.05489134
144tricarboxylic acid cycle (GO:0006099)3.05419649
145polyol transport (GO:0015791)3.05238500
146biotin metabolic process (GO:0006768)3.04330399
147nephron epithelium development (GO:0072009)3.03505232
148regulation of tolerance induction (GO:0002643)3.00056041
149axonemal dynein complex assembly (GO:0070286)20.5932678
150carnitine transmembrane transport (GO:1902603)2.99616143
151iron ion import (GO:0097286)2.99175855
152aldehyde catabolic process (GO:0046185)2.99160247
153calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.96781326
154response to thyroid hormone (GO:0097066)2.95495601
155microtubule polymerization or depolymerization (GO:0031109)2.95463941
156hormone catabolic process (GO:0042447)2.94880902
157indole-containing compound metabolic process (GO:0042430)2.93494476
158glucuronate metabolic process (GO:0019585)2.92666148
159hydrogen peroxide catabolic process (GO:0042744)2.92518763
160sodium ion homeostasis (GO:0055078)2.91934173
161water homeostasis (GO:0030104)2.91883088
162positive regulation of smoothened signaling pathway (GO:0045880)2.90661123
163microtubule depolymerization (GO:0007019)2.89511645
164regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88123526
165progesterone metabolic process (GO:0042448)2.80170397
166dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.72082055
167regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.66861032
168regulation of microtubule depolymerization (GO:0031114)2.61826694
169determination of left/right symmetry (GO:0007368)2.60073112
170phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.59676056
171sperm motility (GO:0030317)2.59278579
172apical protein localization (GO:0045176)2.58485095
173oligosaccharide biosynthetic process (GO:0009312)2.58117608
174lateral sprouting from an epithelium (GO:0060601)2.57770572
175hydrogen peroxide metabolic process (GO:0042743)2.57300093
176regulation of autophagic vacuole assembly (GO:2000785)2.56358341
177regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.55946890
178phenol-containing compound catabolic process (GO:0019336)2.52575082
179phosphatidylcholine biosynthetic process (GO:0006656)2.50994423
180regulation of apoptotic cell clearance (GO:2000425)2.50765179
181regulation of response to osmotic stress (GO:0047484)2.50268409
182determination of bilateral symmetry (GO:0009855)2.50108294
183hypotonic response (GO:0006971)2.46118793
184smoothened signaling pathway (GO:0007224)2.44401156
185specification of symmetry (GO:0009799)2.43857943
186cilium or flagellum-dependent cell motility (GO:0001539)16.7571040
187cilium movement (GO:0003341)14.5002774
188motile cilium assembly (GO:0044458)13.8769772
189epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.3656580
190epithelial cilium movement (GO:0003351)12.5649202
191urate metabolic process (GO:0046415)10.2189853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.06793436
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.33044206
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.86745086
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.22108822
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.76132031
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.36451273
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.32634339
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.95892735
9DROSHA_22980978_ChIP-Seq_HELA_Human2.95171171
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.86578748
11CLOCK_20551151_ChIP-Seq_293T_Human2.82325930
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.71523148
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61805118
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.41243167
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.33330038
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21306503
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.19542979
18CDX2_20551321_ChIP-Seq_CACO-2_Human2.17821504
19GATA1_22025678_ChIP-Seq_K562_Human2.17586858
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.06857602
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.06337826
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94218209
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76601538
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74774461
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.74524352
26VDR_22108803_ChIP-Seq_LS180_Human1.70785585
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69972634
28* ARNT_22903824_ChIP-Seq_MCF-7_Human1.68762754
29FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67043288
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63784335
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58988875
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58730787
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54983903
34STAT1_20625510_ChIP-Seq_HELA_Human1.51896327
35KLF5_25053715_ChIP-Seq_YYC3_Human1.50603551
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.49633518
37GATA4_25053715_ChIP-Seq_YYC3_Human1.49123574
38PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.48872580
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45361350
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.42302512
41LXR_22292898_ChIP-Seq_THP-1_Human1.42271591
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40218342
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40118030
44RACK7_27058665_Chip-Seq_MCF-7_Human1.39149096
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38622248
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.35869426
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.35869426
48FOXA1_25552417_ChIP-Seq_VCAP_Human1.35421606
49CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35189417
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34309905
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.32951389
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31646428
53SOX2_20726797_ChIP-Seq_SW620_Human1.31501131
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.29500437
55HNF4A_19822575_ChIP-Seq_HepG2_Human1.29351294
56AR_21909140_ChIP-Seq_LNCAP_Human1.29062025
57GATA3_24758297_ChIP-Seq_MCF-7_Human1.26992121
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25474167
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.22104753
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20951692
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20670258
62TP53_18474530_ChIP-ChIP_U2OS_Human1.20335981
63* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19728747
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19395986
65* ETV1_20927104_ChIP-Seq_GIST48_Human1.19265859
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18967032
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18931794
68SMRT_27268052_Chip-Seq_Bcells_Human1.18750130
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18495370
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17599871
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15891920
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15496361
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14712740
74* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12865835
75* PHF8_20622853_ChIP-Seq_HELA_Human1.11397055
76GATA6_25053715_ChIP-Seq_YYC3_Human1.08244613
77* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07761182
78* HNFA_21074721_ChIP-Seq_CACO-2_Human1.06871175
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06787464
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05752333
81CTCF_27219007_Chip-Seq_Bcells_Human1.04090008
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01591598
83FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01561697
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.01388291
85EGR1_19032775_ChIP-ChIP_M12_Human1.00521236
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00099422
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98324383
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98299938
89* RBPJ_21746931_ChIP-Seq_IB4_Human0.96664694
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95192888
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94630439
92STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94406368
93RXR_22108803_ChIP-Seq_LS180_Human0.93635226
94* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93209056
95AR_21572438_ChIP-Seq_LNCaP_Human0.93092156
96CEBPB_22108803_ChIP-Seq_LS180_Human0.93040661
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91246520
98* GATA6_21074721_ChIP-Seq_CACO-2_Human0.90836716
99SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90761285
100IRF8_22096565_ChIP-ChIP_GC-B_Human0.90366115
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.90304394
102YY1_22570637_ChIP-Seq_MALME-3M_Human0.90069977
103CREB1_26743006_Chip-Seq_LNCaP_Human0.89440149
104TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88478944
105CTCF_20526341_ChIP-Seq_ESCs_Human0.88365928
106* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.87522925
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86694182
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86655032
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85524888
110CJUN_26792858_Chip-Seq_BT549_Human0.85506293
111SMAD4_21799915_ChIP-Seq_A2780_Human0.85046704
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.84744729
113BCAT_22108803_ChIP-Seq_LS180_Human0.84537978
114* NFYA_21822215_ChIP-Seq_K562_Human0.84012945
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83019105
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82700231
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82700231
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82592341
119GATA2_19941826_ChIP-Seq_K562_Human0.82242757
120GATA1_19941826_ChIP-Seq_K562_Human0.82226065
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.82173347
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81696968
123ZNF263_19887448_ChIP-Seq_K562_Human0.81342753
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81284716
125* SMAD3_21741376_ChIP-Seq_HESCs_Human0.80803024
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80710655
127SOX2_21211035_ChIP-Seq_LN229_Human0.80567360
128* TBL1_22424771_ChIP-Seq_293T_Human0.80554484
129* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80230267
130P68_20966046_ChIP-Seq_HELA_Human0.80136558
131AHR_22903824_ChIP-Seq_MCF-7_Human0.79085752
132P300_27268052_Chip-Seq_Bcells_Human0.78857938
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.78857007
134* NFYB_21822215_ChIP-Seq_K562_Human0.78470555
135* TP63_23658742_ChIP-Seq_EP156T_Human0.77970757
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76300919
137CSB_26484114_Chip-Seq_FIBROBLAST_Human0.74908938
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.73790880
139CDX2_22108803_ChIP-Seq_LS180_Human0.73789645
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73608220
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.72842387
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72556184
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.71431841
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70927644
145TP63_22573176_ChIP-Seq_HFKS_Human0.70877667
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69778621
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69350817
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.68576968
149CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.68446272
150SMC4_20622854_ChIP-Seq_HELA_Human0.68230916
151SOX2_18692474_ChIP-Seq_MEFs_Mouse0.68027373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.10711676
2MP0002653_abnormal_ependyma_morphology5.42005021
3MP0002139_abnormal_hepatobiliary_system5.23525222
4MP0004043_abnormal_pH_regulation5.13464090
5MP0002132_abnormal_respiratory_system4.85853897
6MP0002138_abnormal_hepatobiliary_system4.59496685
7MP0004019_abnormal_vitamin_homeostasis4.54756328
8MP0005332_abnormal_amino_acid4.39095447
9MP0008875_abnormal_xenobiotic_pharmacok3.60904760
10MP0009643_abnormal_urine_homeostasis3.60337843
11MP0001984_abnormal_olfaction3.56750936
12MP0002277_abnormal_respiratory_mucosa3.45904032
13MP0001765_abnormal_ion_homeostasis3.39942108
14MP0001958_emphysema3.18895555
15MP0004133_heterotaxia3.05801069
16MP0008789_abnormal_olfactory_epithelium2.99100735
17MP0005636_abnormal_mineral_homeostasis2.80848103
18MP0003195_calcinosis2.76342856
19MP0001756_abnormal_urination2.66266647
20MP0002136_abnormal_kidney_physiology2.65195683
21MP0005085_abnormal_gallbladder_physiolo2.55505398
22MP0000383_abnormal_hair_follicle2.53049015
23MP0005365_abnormal_bile_salt2.51586420
24MP0000566_synostosis2.49304950
25MP0003252_abnormal_bile_duct2.47132060
26MP0005623_abnormal_meninges_morphology2.39883366
27MP0005377_hearing/vestibular/ear_phenot2.25975955
28MP0003878_abnormal_ear_physiology2.25975955
29MP0010678_abnormal_skin_adnexa2.22721290
30MP0005058_abnormal_lysosome_morphology2.04714653
31MP0005499_abnormal_olfactory_system1.88336769
32MP0005394_taste/olfaction_phenotype1.88336769
33MP0003186_abnormal_redox_activity1.74289744
34MP0003300_gastrointestinal_ulcer1.73652954
35MP0003724_increased_susceptibility_to1.72473200
36MP0003656_abnormal_erythrocyte_physiolo1.71183194
37MP0002282_abnormal_trachea_morphology1.67826167
38MP0008995_early_reproductive_senescence1.66146937
39MP0003191_abnormal_cellular_cholesterol1.60402028
40MP0005584_abnormal_enzyme/coenzyme_acti1.58852613
41MP0002909_abnormal_adrenal_gland1.57638990
42MP0010368_abnormal_lymphatic_system1.53199272
43MP0002160_abnormal_reproductive_system1.47935765
44MP0005319_abnormal_enzyme/_coenzyme1.47412578
45MP0003806_abnormal_nucleotide_metabolis1.43420853
46MP0005167_abnormal_blood-brain_barrier1.40358567
47MP0008961_abnormal_basal_metabolism1.39312030
48MP0001879_abnormal_lymphatic_vessel1.39244839
49MP0005084_abnormal_gallbladder_morpholo1.35619304
50MP0000465_gastrointestinal_hemorrhage1.35081479
51MP0005670_abnormal_white_adipose1.34677607
52MP0004883_abnormal_blood_vessel1.34000449
53MP0004885_abnormal_endolymph1.32809546
54MP0005164_abnormal_response_to1.32145697
55MP0004147_increased_porphyrin_level1.22063078
56MP0000538_abnormal_urinary_bladder1.21950250
57MP0004782_abnormal_surfactant_physiolog1.20534759
58MP0000230_abnormal_systemic_arterial1.18253549
59MP0001346_abnormal_lacrimal_gland1.17505576
60MP0005666_abnormal_adipose_tissue1.17200615
61MP0010155_abnormal_intestine_physiology1.13888936
62MP0002168_other_aberrant_phenotype1.13502194
63MP0001666_abnormal_nutrient_absorption1.12812040
64MP0005248_abnormal_Harderian_gland1.11733507
65MP0010329_abnormal_lipoprotein_level1.11733115
66MP0004272_abnormal_basement_membrane1.11721378
67MP0002118_abnormal_lipid_homeostasis1.10765774
68MP0006036_abnormal_mitochondrial_physio1.07296052
69MP0002135_abnormal_kidney_morphology1.03026832
70MP0003950_abnormal_plasma_membrane1.01091424
71MP0002638_abnormal_pupillary_reflex0.99853781
72MP0010234_abnormal_vibrissa_follicle0.99786996
73MP0002928_abnormal_bile_duct0.99090565
74MP0002796_impaired_skin_barrier0.98582120
75MP0009764_decreased_sensitivity_to0.96509664
76MP0005451_abnormal_body_composition0.95652023
77MP0002249_abnormal_larynx_morphology0.95409043
78MP0000681_abnormal_thyroid_gland0.92490425
79MP0002896_abnormal_bone_mineralization0.91192146
80MP0006054_spinal_hemorrhage0.89823802
81MP0002876_abnormal_thyroid_physiology0.89815431
82MP0000609_abnormal_liver_physiology0.86189914
83MP0001764_abnormal_homeostasis0.85833272
84MP0003705_abnormal_hypodermis_morpholog0.85801744
85MP0005503_abnormal_tendon_morphology0.84569983
86MP0005535_abnormal_body_temperature0.83990860
87MP0003638_abnormal_response/metabolism_0.82529416
88MP0002405_respiratory_system_inflammati0.81531849
89MP0001542_abnormal_bone_strength0.79670831
90MP0004264_abnormal_extraembryonic_tissu0.78590201
91MP0002089_abnormal_postnatal_growth/wei0.78556922
92MP0010030_abnormal_orbit_morphology0.77800384
93MP0002734_abnormal_mechanical_nocicepti0.76967766
94MP0002233_abnormal_nose_morphology0.76442369
95MP0009379_abnormal_foot_pigmentation0.75692209
96MP0009642_abnormal_blood_homeostasis0.75524992
97MP0003453_abnormal_keratinocyte_physiol0.75018526
98MP0003303_peritoneal_inflammation0.72567875
99MP0005165_increased_susceptibility_to0.71945373
100MP0001661_extended_life_span0.71429411
101MP0002735_abnormal_chemical_nociception0.70891055
102MP0001485_abnormal_pinna_reflex0.70617725
103MP0005083_abnormal_biliary_tract0.68725789
104MP0005387_immune_system_phenotype0.68592322
105MP0001790_abnormal_immune_system0.68592322
106MP0005023_abnormal_wound_healing0.67776042
107MP0008469_abnormal_protein_level0.66661620
108MP0005253_abnormal_eye_physiology0.66387149
109MP0003136_yellow_coat_color0.65624404
110MP0005501_abnormal_skin_physiology0.63858288
111MP0005551_abnormal_eye_electrophysiolog0.63815515
112MP0005375_adipose_tissue_phenotype0.63561535
113MP0005389_reproductive_system_phenotype0.62145254
114MP0005408_hypopigmentation0.61747030
115MP0000598_abnormal_liver_morphology0.60561714
116MP0004130_abnormal_muscle_cell0.60157498
117MP0003283_abnormal_digestive_organ0.59238937
118MP0006082_CNS_inflammation0.58700985
119MP0001664_abnormal_digestion0.58513182
120MP0002295_abnormal_pulmonary_circulatio0.58375477
121MP0009765_abnormal_xenobiotic_induced0.57434484
122MP0000467_abnormal_esophagus_morphology0.57279972
123MP0000747_muscle_weakness0.56649556
124MP0000249_abnormal_blood_vessel0.56553157
125MP0002098_abnormal_vibrissa_morphology0.56234415
126MP0003566_abnormal_cell_adhesion0.56139003
127MP0009763_increased_sensitivity_to0.56063361
128MP0005595_abnormal_vascular_smooth0.56015810
129MP0001502_abnormal_circadian_rhythm0.55797370
130MP0003172_abnormal_lysosome_physiology0.55721644
131MP0003828_pulmonary_edema0.55497372
132MP0002998_abnormal_bone_remodeling0.50802760
133MP0000013_abnormal_adipose_tissue0.50793029
134MP0005220_abnormal_exocrine_pancreas0.50248051
135MP0005395_other_phenotype0.50218950
136MP0008004_abnormal_stomach_pH0.49183496
137MP0001849_ear_inflammation0.48672405
138MP0000371_diluted_coat_color0.48634178
139MP0002133_abnormal_respiratory_system0.47804184
140MP0005388_respiratory_system_phenotype0.47804184
141MP0005646_abnormal_pituitary_gland0.47454214
142MP0004484_altered_response_of0.47444774
143MP0000343_altered_response_to0.47314492
144MP0009046_muscle_twitch0.46081067
145MP0003646_muscle_fatigue0.46048118
146MP0002078_abnormal_glucose_homeostasis0.45317965
147MP0005166_decreased_susceptibility_to0.44864115
148MP0001324_abnormal_eye_pigmentation0.43955305
149MP0003075_altered_response_to0.43927686
150MP0001270_distended_abdomen0.43762012
151MP0001929_abnormal_gametogenesis0.43603989
152MP0000026_abnormal_inner_ear0.43282681
153MP0001663_abnormal_digestive_system0.43242456
154MP0008872_abnormal_physiological_respon0.43097731
155MP0000678_abnormal_parathyroid_gland0.42348684
156MP0002115_abnormal_skeleton_extremities0.42334246
157MP0002971_abnormal_brown_adipose0.42298583
158MP0001177_atelectasis0.42226820
159MP0006138_congestive_heart_failure0.41709459
160MP0003329_amyloid_beta_deposits0.41359559
161MP0009780_abnormal_chondrocyte_physiolo0.39866755
162MP0003795_abnormal_bone_structure0.39022014

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)8.15677348
2Bronchiectasis (HP:0002110)7.37151450
3Hyperactive renin-angiotensin system (HP:0000841)6.99580683
4Hypokalemic alkalosis (HP:0001949)6.90227090
5Increased circulating renin level (HP:0000848)6.84861963
6Gout (HP:0001997)6.64901672
7Nasal polyposis (HP:0100582)6.56703423
8Metabolic alkalosis (HP:0200114)6.29093505
9Hypomagnesemia (HP:0002917)5.96174126
10Abnormality of chloride homeostasis (HP:0011422)5.90799750
11Polyuria (HP:0000103)5.69609214
12Abnormality of the nasal mucosa (HP:0000433)5.57777718
13Abnormal urine output (HP:0012590)5.50366156
14Abnormality of renal excretion (HP:0011036)5.45723613
15Proximal tubulopathy (HP:0000114)5.25244367
16Abnormality of magnesium homeostasis (HP:0004921)5.06203509
17Abnormality of renin-angiotensin system (HP:0000847)4.74094053
18Increased purine levels (HP:0004368)4.71754836
19Hyperuricemia (HP:0002149)4.71754836
20Renal salt wasting (HP:0000127)4.68103989
21Polydipsia (HP:0001959)4.62893261
22Abnormal drinking behavior (HP:0030082)4.62893261
23Alkalosis (HP:0001948)4.56768187
24Abnormality of purine metabolism (HP:0004352)4.56301838
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.55216049
26Hyperglycinuria (HP:0003108)4.54188892
27Hyperaldosteronism (HP:0000859)4.52191823
28Bronchitis (HP:0012387)4.51617009
29Recurrent sinusitis (HP:0011108)4.32898300
30Generalized aminoaciduria (HP:0002909)4.23852143
31Tetany (HP:0001281)4.21365619
32Chronic sinusitis (HP:0011109)4.17650144
33Infertility (HP:0000789)4.15521232
34Male infertility (HP:0003251)3.87288008
35Recurrent otitis media (HP:0000403)3.85559179
36Abnormality of glycine metabolism (HP:0010895)3.76644512
37Abnormality of serine family amino acid metabolism (HP:0010894)3.76644512
38Glycosuria (HP:0003076)3.62253619
39Abnormality of urine glucose concentration (HP:0011016)3.62253619
40Ketoacidosis (HP:0001993)3.61770304
41Hypercalciuria (HP:0002150)3.61274411
42Occipital encephalocele (HP:0002085)3.44915377
43Hypokalemia (HP:0002900)3.38973058
44Abnormality of nucleobase metabolism (HP:0010932)3.34120851
45Pancreatic fibrosis (HP:0100732)3.33251684
46Ketosis (HP:0001946)3.30412124
47True hermaphroditism (HP:0010459)3.28660234
48Vascular calcification (HP:0004934)3.23371073
49Renal tubular acidosis (HP:0001947)3.16783765
50Hydroxyprolinuria (HP:0003080)3.13445854
51Abnormality of proline metabolism (HP:0010907)3.13445854
52Hyperphosphaturia (HP:0003109)3.09254403
53Chronic otitis media (HP:0000389)3.04235449
54Atelectasis (HP:0100750)3.02688867
55Abnormal urine phosphate concentration (HP:0012599)2.98160552
56Abnormality of potassium homeostasis (HP:0011042)2.97939429
57Delayed epiphyseal ossification (HP:0002663)2.94593944
58Nephrolithiasis (HP:0000787)2.92351910
59Cardiovascular calcification (HP:0011915)2.91516117
60Cystic liver disease (HP:0006706)2.76463196
61Abnormality of fatty-acid metabolism (HP:0004359)2.74311888
62Pancreatic cysts (HP:0001737)2.72669657
63Hypophosphatemia (HP:0002148)2.67967332
64Hyperglycinemia (HP:0002154)2.67450618
65Rickets (HP:0002748)2.65957948
66Molar tooth sign on MRI (HP:0002419)2.65235350
67Abnormality of midbrain morphology (HP:0002418)2.65235350
68Nephrocalcinosis (HP:0000121)2.63285305
69Widely patent fontanelles and sutures (HP:0004492)2.62263264
70Nephronophthisis (HP:0000090)2.62058172
71Hyperammonemia (HP:0001987)2.56626933
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56061775
73Delayed CNS myelination (HP:0002188)2.55891281
74Dicarboxylic aciduria (HP:0003215)2.50188157
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50188157
76Vacuolated lymphocytes (HP:0001922)2.49635282
77Metaphyseal cupping (HP:0003021)2.48845102
78Dehydration (HP:0001944)2.46886856
79Hyponatremia (HP:0002902)2.42028352
80Metabolic acidosis (HP:0001942)2.38386940
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36428369
82Chronic hepatic failure (HP:0100626)2.36000776
83Tubulointerstitial fibrosis (HP:0005576)2.34010928
84Abnormal enzyme/coenzyme activity (HP:0012379)2.32360669
85Facial shape deformation (HP:0011334)2.32086057
86Potter facies (HP:0002009)2.32086057
87Abnormality of sodium homeostasis (HP:0010931)2.31142987
88Malnutrition (HP:0004395)2.31110058
89Tubulointerstitial nephritis (HP:0001970)2.30919889
90Lymphangioma (HP:0100764)2.27731259
91Vomiting (HP:0002013)2.27598717
92Postaxial foot polydactyly (HP:0001830)2.26558424
93Thin bony cortex (HP:0002753)2.23934342
94Abnormality of alkaline phosphatase activity (HP:0004379)2.23310448
95Enlarged kidneys (HP:0000105)2.14628397
96Abnormality of the renal medulla (HP:0100957)2.11538615
97Adrenal overactivity (HP:0002717)2.11128782
98Interstitial pulmonary disease (HP:0006530)2.10496611
99Tachypnea (HP:0002789)2.09953053
100Chondrocalcinosis (HP:0000934)2.09769167
101Decreased circulating renin level (HP:0003351)2.09226107
102Abnormality of renal resorption (HP:0011038)2.08119701
103Hyperkalemia (HP:0002153)2.05999375
104Methylmalonic aciduria (HP:0012120)2.03905410
105Abnormal tarsal ossification (HP:0008369)2.03764324
106Bell-shaped thorax (HP:0001591)2.03160174
107Congenital hepatic fibrosis (HP:0002612)2.02114907
108Recurrent bronchitis (HP:0002837)2.01325525
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3114301
110Abnormal respiratory motile cilium morphology (HP:0005938)11.1013098
111Abnormal respiratory epithelium morphology (HP:0012253)11.1013098
112Abnormal respiratory motile cilium physiology (HP:0012261)10.7896449
113Dynein arm defect of respiratory motile cilia (HP:0012255)10.7682481
114Absent/shortened dynein arms (HP:0200106)10.7682481
115Abnormal ciliary motility (HP:0012262)10.5109116
116Rhinitis (HP:0012384)10.0565278
117Lethargy (HP:0001254)1.97808359
118Visceral angiomatosis (HP:0100761)1.97717960
119Confusion (HP:0001289)1.95486839
120Abnormality of Sharpey fibers (HP:0100685)1.94929456
121Glomerulosclerosis (HP:0000096)1.94573231
122Xanthomatosis (HP:0000991)1.94340167
123Sensorimotor neuropathy (HP:0007141)1.93127055
124Renal tubular dysfunction (HP:0000124)1.89735344
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.88703293
126Male pseudohermaphroditism (HP:0000037)1.86982918
127Nausea (HP:0002018)1.84747886
128Bilateral sensorineural hearing impairment (HP:0008619)1.84725531
129Hypotension (HP:0002615)1.84511347
130Anencephaly (HP:0002323)1.84226127
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.82996645
132Elevated alkaline phosphatase (HP:0003155)1.81273853
133Abnormality of the costochondral junction (HP:0000919)1.81064484
134Hemangiomatosis (HP:0007461)1.79012422
135Absent frontal sinuses (HP:0002688)1.77782154
136Asplenia (HP:0001746)1.75277573
137Aplasia/Hypoplasia of the spleen (HP:0010451)1.75026630
138Tubular atrophy (HP:0000092)1.74137942
139Intrahepatic cholestasis (HP:0001406)1.73341079
140Medial flaring of the eyebrow (HP:0010747)1.71661912
141Irritability (HP:0000737)1.71265173
142Cavernous hemangioma (HP:0001048)1.70567635
143Nephropathy (HP:0000112)1.68729371
144Bicornuate uterus (HP:0000813)1.67105197
145Furrowed tongue (HP:0000221)1.62668400
146Congenital primary aphakia (HP:0007707)1.56640959
147Gait imbalance (HP:0002141)1.53923092
148Tubulointerstitial abnormality (HP:0001969)1.52279892
149Glucose intolerance (HP:0000833)1.52036012
150Sclerocornea (HP:0000647)1.50720173
151Oculomotor apraxia (HP:0000657)1.50135298
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.40111049
153Postaxial hand polydactyly (HP:0001162)1.39615705
154Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.34981460
155Nephrogenic diabetes insipidus (HP:0009806)1.34446230
156Abnormality of the distal phalanges of the toes (HP:0010182)1.32570874
157Decreased central vision (HP:0007663)1.28510543
158Stage 5 chronic kidney disease (HP:0003774)1.28068907
159Muscle fiber splitting (HP:0003555)1.27842714
160Abnormality of permanent molar morphology (HP:0011071)1.25712055
161Abnormality of the dental root (HP:0006486)1.25712055
162Taurodontia (HP:0000679)1.25712055
163Lip pit (HP:0100267)1.25503545
164Short thorax (HP:0010306)1.24794533
165Cone-rod dystrophy (HP:0000548)1.23838070
166Hand muscle atrophy (HP:0009130)1.21334862
167Aplasia of the musculature (HP:0100854)1.20786444
168Short nail (HP:0001799)1.19448603
169Median cleft lip (HP:0000161)1.19168703
170Bifid scrotum (HP:0000048)1.18818389
171Distal lower limb muscle weakness (HP:0009053)1.18070533
172Abnormality of the dental pulp (HP:0006479)1.17435253
173Abnormality of molar morphology (HP:0011070)1.16779869
174Abnormality of molar (HP:0011077)1.16779869
175Abnormality of monocarboxylic acid metabolism (HP:0010996)1.16392766
176Preaxial hand polydactyly (HP:0001177)1.12350290
177Popliteal pterygium (HP:0009756)1.09828225
178Vaginal atresia (HP:0000148)1.08509282
179Genital tract atresia (HP:0001827)1.07898488
180Abnormality of the frontal sinuses (HP:0002687)1.07897855
181Obstructive sleep apnea (HP:0002870)1.07872142
182Spinal muscular atrophy (HP:0007269)1.07334776
183Fetal akinesia sequence (HP:0001989)1.07236362
184Alveolar cell carcinoma (HP:0006519)1.06842010
185Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.04912033
186Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.04515600
187Short femoral neck (HP:0100864)1.03332710
188Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.02391511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.51368849
2OXSR16.22485287
3WNK35.74100674
4EPHA24.68901746
5STK394.24713001
6TIE13.75231878
7BCKDK3.23031921
8MAPKAPK32.62666636
9KDR2.55345325
10NME12.22206938
11STK38L2.17704706
12TGFBR22.15598261
13PDK31.88177150
14PDK41.88177150
15MST1R1.79619026
16STK241.78273144
17EPHA31.75497889
18WNK11.67083441
19FGFR41.66634244
20EEF2K1.63083693
21SMG11.58754446
22SGK4941.50382643
23SGK2231.50382643
24NEK11.50355075
25PDK21.44905252
26ERN11.42681142
27LRRK21.42558600
28EPHB11.37064431
29MST41.35750678
30BCR1.31437048
31TRPM71.29673454
32TTK1.22393534
33NEK61.19986939
34MARK21.08733184
35STK381.06142171
36MAP3K31.05685076
37TLK11.01306457
38TRIB31.00930852
39RIPK10.96375180
40MYLK0.89356073
41EPHB20.88844067
42FER0.87512607
43ERBB30.86357029
44PAK40.86144820
45PTK60.86123984
46GSK3A0.85094961
47TESK10.83683058
48NLK0.83278325
49SGK30.80327783
50PINK10.80190646
51GRK60.75689313
52STK100.72175043
53TGFBR10.71418452
54MET0.71124514
55PTK20.70726206
56SGK20.69563436
57BRSK20.68923649
58MAP3K120.68844647
59IRAK10.67717404
60MAP3K70.66813275
61ERBB20.61746679
62PDPK10.58987986
63GRK10.58585484
64CAMKK10.58249998
65RIPK40.57343002
66HIPK20.55553203
67MAP3K20.55530152
68PTK2B0.54042836
69DYRK1B0.53928101
70MAP2K30.53196650
71MAPK150.50088202
72CDC42BPA0.50023928
73FRK0.48345135
74MAPK110.48153915
75ABL20.47193820
76RPS6KA20.46072201
77PRKCQ0.45803821
78PRKAA20.44126177
79INSRR0.42877461
80CSK0.42541336
81ICK0.42300493
82MUSK0.42143996
83PNCK0.41623292
84SGK10.41357743
85CAMK2G0.38823563
86PRKAA10.38332079
87MAP3K60.37911532
88JAK20.37837494
89STK160.34678321
90LATS10.33741793
91PRKCH0.33611288
92PRKD20.33231970
93PDGFRA0.32949758
94ADRBK10.32644957
95PAK30.32085810
96ZAP700.31952137
97ABL10.31830274
98PDK10.31560964
99JAK10.31474548
100RPS6KB20.30040925
101MAP3K40.30025193
102FGFR20.29441055
103DAPK20.29343688
104MAPKAPK50.28966257
105PRKCZ0.28116847
106TYK20.25428467
107LMTK20.25340363
108SIK10.24984805
109CHUK0.24103318
110PRKCD0.22974178
111NEK90.22830788
112AKT20.22810645
113ADRBK20.22626819
114NTRK10.22475263
115CAMK40.22140252
116MAPK120.21117019
117ROCK20.20983197
118PRKD10.19353628
119AURKA0.19289384
120PRKACG0.18959484
121MAP3K140.18838192
122CAMKK20.18780181
123IRAK30.17758597
124PRKCI0.17614697
125MAP3K110.17285969
126TTN0.16393953
127PRKG20.16346215
128MAP2K20.16203980
129STK110.15956759
130MAP2K10.15760898
131SRC0.15562908
132FGFR30.15459060
133OBSCN0.15449689
134PRKCE0.15187558
135EGFR0.14844012
136CAMK2A0.14181036
137ROCK10.13985244
138TBK10.13698232
139IGF1R0.13586608
140ERBB40.13205881
141BMX0.13202132
142MAP2K40.10399855
143INSR0.09665304
144PRKCA0.09624833
145PRKACA0.08736698
146PKN20.07735704
147MAPK40.07441375

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.59946306
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.50202605
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40365022
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.19517813
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.17118990
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.12311613
7Propanoate metabolism_Homo sapiens_hsa006403.03490016
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.94575522
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.92059822
10Fatty acid degradation_Homo sapiens_hsa000712.59735821
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.43771150
12Peroxisome_Homo sapiens_hsa041462.42163329
13Pyruvate metabolism_Homo sapiens_hsa006202.40115063
14Tryptophan metabolism_Homo sapiens_hsa003802.35802943
15Linoleic acid metabolism_Homo sapiens_hsa005912.21973514
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12873259
17Huntingtons disease_Homo sapiens_hsa050162.01867429
18beta-Alanine metabolism_Homo sapiens_hsa004101.97898674
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95178547
20Fatty acid metabolism_Homo sapiens_hsa012121.91868540
21Vitamin digestion and absorption_Homo sapiens_hsa049771.91863362
22Sulfur metabolism_Homo sapiens_hsa009201.89618488
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89598368
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83766086
25Collecting duct acid secretion_Homo sapiens_hsa049661.75907949
26Bile secretion_Homo sapiens_hsa049761.66809661
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65998182
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59130246
29Glutathione metabolism_Homo sapiens_hsa004801.53799718
30Carbon metabolism_Homo sapiens_hsa012001.53606339
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.52306231
32PPAR signaling pathway_Homo sapiens_hsa033201.50633493
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46807917
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41255907
35Histidine metabolism_Homo sapiens_hsa003401.40298903
36Arginine and proline metabolism_Homo sapiens_hsa003301.37804433
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34652843
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33294260
39Mineral absorption_Homo sapiens_hsa049781.25083175
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22069832
41Starch and sucrose metabolism_Homo sapiens_hsa005001.19540501
42Selenocompound metabolism_Homo sapiens_hsa004501.18394824
43Arginine biosynthesis_Homo sapiens_hsa002201.18363885
44Circadian rhythm_Homo sapiens_hsa047101.15134058
45Protein digestion and absorption_Homo sapiens_hsa049741.13471759
46Phenylalanine metabolism_Homo sapiens_hsa003601.12342903
47Other glycan degradation_Homo sapiens_hsa005111.12207137
48Lysine degradation_Homo sapiens_hsa003101.10192761
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10021343
50Nitrogen metabolism_Homo sapiens_hsa009101.09762377
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03798679
52Glycerolipid metabolism_Homo sapiens_hsa005611.02440138
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94992715
54Salivary secretion_Homo sapiens_hsa049700.93372990
55Folate biosynthesis_Homo sapiens_hsa007900.90318547
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86666112
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85914616
58Chemical carcinogenesis_Homo sapiens_hsa052040.83655746
59Renin-angiotensin system_Homo sapiens_hsa046140.80509694
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77273407
61Fatty acid elongation_Homo sapiens_hsa000620.76995255
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.75829328
63Biosynthesis of amino acids_Homo sapiens_hsa012300.72859590
64Adherens junction_Homo sapiens_hsa045200.68666794
65Hepatitis C_Homo sapiens_hsa051600.68127536
66Retinol metabolism_Homo sapiens_hsa008300.67805760
67Fructose and mannose metabolism_Homo sapiens_hsa000510.66608114
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.66441511
69Taste transduction_Homo sapiens_hsa047420.63914088
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.63437001
71Lysosome_Homo sapiens_hsa041420.63007487
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62532755
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61027594
74Phototransduction_Homo sapiens_hsa047440.58824018
75Pentose phosphate pathway_Homo sapiens_hsa000300.57074457
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.56617025
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56140607
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.53475484
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.53207171
80Notch signaling pathway_Homo sapiens_hsa043300.49933849
81Thyroid hormone synthesis_Homo sapiens_hsa049180.49529456
82ABC transporters_Homo sapiens_hsa020100.48646645
83Staphylococcus aureus infection_Homo sapiens_hsa051500.47903995
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45954783
85Ovarian steroidogenesis_Homo sapiens_hsa049130.45951490
86Metabolic pathways_Homo sapiens_hsa011000.45739674
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45539663
88Caffeine metabolism_Homo sapiens_hsa002320.44412779
89Oxidative phosphorylation_Homo sapiens_hsa001900.43650229
90Hematopoietic cell lineage_Homo sapiens_hsa046400.42410935
91Tyrosine metabolism_Homo sapiens_hsa003500.41339710
92Gastric acid secretion_Homo sapiens_hsa049710.40245134
93Asthma_Homo sapiens_hsa053100.37629371
94Serotonergic synapse_Homo sapiens_hsa047260.35414106
95Type I diabetes mellitus_Homo sapiens_hsa049400.35141512
96Dilated cardiomyopathy_Homo sapiens_hsa054140.35104522
97Olfactory transduction_Homo sapiens_hsa047400.34931310
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34011520
99Complement and coagulation cascades_Homo sapiens_hsa046100.33036190
100Allograft rejection_Homo sapiens_hsa053300.32745710
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.32563607
102Amoebiasis_Homo sapiens_hsa051460.31882040
103Fatty acid biosynthesis_Homo sapiens_hsa000610.31578241
104Arachidonic acid metabolism_Homo sapiens_hsa005900.31461503
105Pertussis_Homo sapiens_hsa051330.30931431
106Autoimmune thyroid disease_Homo sapiens_hsa053200.30427229
107Hedgehog signaling pathway_Homo sapiens_hsa043400.30371942
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30237702
109Ether lipid metabolism_Homo sapiens_hsa005650.29692729
110Sulfur relay system_Homo sapiens_hsa041220.27078320
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.26304225
112Pancreatic secretion_Homo sapiens_hsa049720.26214252
113Graft-versus-host disease_Homo sapiens_hsa053320.26208047
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25469372
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22285705
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21990473
117cAMP signaling pathway_Homo sapiens_hsa040240.21656414
118Vibrio cholerae infection_Homo sapiens_hsa051100.21300525
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.21003887
120Sphingolipid metabolism_Homo sapiens_hsa006000.20652010
121Insulin resistance_Homo sapiens_hsa049310.20508588
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20250006
123Steroid biosynthesis_Homo sapiens_hsa001000.19758049
124Basal cell carcinoma_Homo sapiens_hsa052170.18986004
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17586074
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16696051
127Parkinsons disease_Homo sapiens_hsa050120.16576771
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.15611344
129Cocaine addiction_Homo sapiens_hsa050300.14789149
130ECM-receptor interaction_Homo sapiens_hsa045120.14163778
131Hippo signaling pathway_Homo sapiens_hsa043900.13311727
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13204397
133Calcium signaling pathway_Homo sapiens_hsa040200.11567830
134Fat digestion and absorption_Homo sapiens_hsa049750.11299020
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11203564
136Choline metabolism in cancer_Homo sapiens_hsa052310.11129977
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10799643
138Galactose metabolism_Homo sapiens_hsa000520.08277318
139Rheumatoid arthritis_Homo sapiens_hsa053230.05635953
140AMPK signaling pathway_Homo sapiens_hsa041520.05569923
141Tight junction_Homo sapiens_hsa045300.02329126
142Bladder cancer_Homo sapiens_hsa052190.01901277
143Cardiac muscle contraction_Homo sapiens_hsa04260-0.0150634
144Phagosome_Homo sapiens_hsa04145-0.0125010
145Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0079826
146Focal adhesion_Homo sapiens_hsa04510-0.0008956
147alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0002084

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