CYP4F11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.76902967
2drug catabolic process (GO:0042737)7.54238739
3epoxygenase P450 pathway (GO:0019373)6.87135779
4cellular glucuronidation (GO:0052695)6.76135155
5omega-hydroxylase P450 pathway (GO:0097267)6.56940011
6glucuronate metabolic process (GO:0019585)6.44937919
7uronic acid metabolic process (GO:0006063)6.44937919
8polyketide metabolic process (GO:0030638)5.90661132
9doxorubicin metabolic process (GO:0044598)5.90661132
10daunorubicin metabolic process (GO:0044597)5.90661132
11flavonoid metabolic process (GO:0009812)5.79952868
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.72896769
13L-phenylalanine catabolic process (GO:0006559)5.72896769
14drug metabolic process (GO:0017144)5.65066518
15complement activation, alternative pathway (GO:0006957)5.43640470
16regulation of protein activation cascade (GO:2000257)5.39998405
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.29004923
18L-phenylalanine metabolic process (GO:0006558)5.29004923
19glyoxylate metabolic process (GO:0046487)5.26807434
20aminoglycoside antibiotic metabolic process (GO:0030647)5.25621121
21phenylpropanoid metabolic process (GO:0009698)5.25019322
22aromatic amino acid family catabolic process (GO:0009074)5.19821638
23regulation of complement activation (GO:0030449)5.14779459
24ethanol oxidation (GO:0006069)5.09353431
25primary alcohol catabolic process (GO:0034310)5.01541131
26oxidative demethylation (GO:0070989)4.93524613
27regulation of fibrinolysis (GO:0051917)4.82232810
28indole-containing compound catabolic process (GO:0042436)4.72643743
29indolalkylamine catabolic process (GO:0046218)4.72643743
30tryptophan catabolic process (GO:0006569)4.72643743
31bile acid biosynthetic process (GO:0006699)4.49929940
32ethanol metabolic process (GO:0006067)4.42686025
33negative regulation of fibrinolysis (GO:0051918)4.42145443
34bile acid metabolic process (GO:0008206)4.35303966
35regulation of triglyceride catabolic process (GO:0010896)4.27732708
36bile acid and bile salt transport (GO:0015721)4.12229116
37intestinal cholesterol absorption (GO:0030299)4.06964681
38serine family amino acid catabolic process (GO:0009071)4.05347319
39tryptophan metabolic process (GO:0006568)3.99572760
40cysteine metabolic process (GO:0006534)3.95125889
41S-adenosylmethionine metabolic process (GO:0046500)3.93077169
42cellular ketone body metabolic process (GO:0046950)3.91413594
43xenobiotic catabolic process (GO:0042178)3.87783907
44aromatic amino acid family metabolic process (GO:0009072)3.75557814
45tyrosine metabolic process (GO:0006570)3.75126587
46amino-acid betaine metabolic process (GO:0006577)3.71816717
47negative regulation of protein activation cascade (GO:2000258)3.70430189
48alkaloid metabolic process (GO:0009820)3.68518996
49retinoic acid metabolic process (GO:0042573)3.67391893
50indolalkylamine metabolic process (GO:0006586)3.65866323
51drug transmembrane transport (GO:0006855)3.65579850
52fibrinolysis (GO:0042730)3.65567479
53arginine metabolic process (GO:0006525)3.65436298
54peptidyl-glutamic acid carboxylation (GO:0017187)3.61165958
55protein carboxylation (GO:0018214)3.61165958
56kynurenine metabolic process (GO:0070189)3.60963126
57negative regulation of cholesterol transport (GO:0032375)3.57512058
58negative regulation of sterol transport (GO:0032372)3.57512058
59blood coagulation, intrinsic pathway (GO:0007597)3.55466232
60triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.54819760
61ketone body metabolic process (GO:1902224)3.52977056
62* xenobiotic metabolic process (GO:0006805)3.50508932
63urea metabolic process (GO:0019627)3.49020837
64high-density lipoprotein particle remodeling (GO:0034375)3.48888109
65heme transport (GO:0015886)3.46437010
66benzene-containing compound metabolic process (GO:0042537)3.41212658
67protein activation cascade (GO:0072376)3.39442791
68alpha-amino acid catabolic process (GO:1901606)3.37082018
69response to nitrosative stress (GO:0051409)3.34322465
70reverse cholesterol transport (GO:0043691)3.34267459
71acylglycerol homeostasis (GO:0055090)3.33043831
72triglyceride homeostasis (GO:0070328)3.33043831
73* quinone metabolic process (GO:1901661)3.29808033
74glycine metabolic process (GO:0006544)3.28333150
75complement activation, classical pathway (GO:0006958)3.24661357
76macromolecular complex remodeling (GO:0034367)3.24166664
77plasma lipoprotein particle remodeling (GO:0034369)3.24166664
78protein-lipid complex remodeling (GO:0034368)3.24166664
79amine catabolic process (GO:0009310)3.23027879
80cellular biogenic amine catabolic process (GO:0042402)3.23027879
81L-methionine salvage (GO:0071267)3.22883006
82L-methionine biosynthetic process (GO:0071265)3.22883006
83amino acid salvage (GO:0043102)3.22883006
84serine family amino acid metabolic process (GO:0009069)3.21160196
85retinal metabolic process (GO:0042574)3.18748910
86nitrogen cycle metabolic process (GO:0071941)3.16347515
87imidazole-containing compound metabolic process (GO:0052803)3.16026228
88complement activation (GO:0006956)3.15947042
89acute-phase response (GO:0006953)3.15028157
90negative regulation of complement activation (GO:0045916)3.14762498
91primary alcohol metabolic process (GO:0034308)3.13949793
92regulation of humoral immune response (GO:0002920)3.08442326
93glutamate metabolic process (GO:0006536)3.06144722
94cholesterol efflux (GO:0033344)3.02743022
95sodium-independent organic anion transport (GO:0043252)3.01838641
96phospholipid efflux (GO:0033700)3.01203978
97arginine catabolic process (GO:0006527)2.99640913
98drug transport (GO:0015893)2.96825496
99negative regulation of hemostasis (GO:1900047)2.95863255
100negative regulation of blood coagulation (GO:0030195)2.95863255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse3.98680234
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.64901669
3GBX2_23144817_ChIP-Seq_PC3_Human2.75404155
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74312110
5VDR_22108803_ChIP-Seq_LS180_Human2.66077881
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.62448552
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.56784960
8IGF1R_20145208_ChIP-Seq_DFB_Human2.50203357
9ZNF274_21170338_ChIP-Seq_K562_Hela2.42952957
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40878875
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.18064892
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13658304
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06910044
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.05911439
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02145217
16ER_23166858_ChIP-Seq_MCF-7_Human1.95730589
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90292376
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89495833
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.86221292
20TAF15_26573619_Chip-Seq_HEK293_Human1.84963372
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81460659
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77721892
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76698267
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.74193271
25BCAT_22108803_ChIP-Seq_LS180_Human1.70121270
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.66072589
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65559444
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57049431
29STAT3_23295773_ChIP-Seq_U87_Human1.56860318
30CBP_20019798_ChIP-Seq_JUKART_Human1.53407814
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53407814
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49767953
33P300_19829295_ChIP-Seq_ESCs_Human1.48850469
34FUS_26573619_Chip-Seq_HEK293_Human1.47568659
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47329050
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46640023
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.44580471
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42698027
39SMAD4_21799915_ChIP-Seq_A2780_Human1.41655667
40* TCF4_23295773_ChIP-Seq_U87_Human1.40798875
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40735847
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40372463
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.40294774
44TCF4_22108803_ChIP-Seq_LS180_Human1.37859035
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36857355
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36630722
47CDX2_22108803_ChIP-Seq_LS180_Human1.36507189
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34474420
49AR_20517297_ChIP-Seq_VCAP_Human1.34300140
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33826819
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33377349
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32828927
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.31668844
54AR_25329375_ChIP-Seq_VCAP_Human1.31555068
55NANOG_19829295_ChIP-Seq_ESCs_Human1.31128073
56SOX2_19829295_ChIP-Seq_ESCs_Human1.31128073
57AHR_22903824_ChIP-Seq_MCF-7_Human1.30639289
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29246505
59GATA4_25053715_ChIP-Seq_YYC3_Human1.28126607
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27687102
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27585975
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27152683
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27057382
64* HNF4A_19822575_ChIP-Seq_HepG2_Human1.26513118
65* FOXA2_19822575_ChIP-Seq_HepG2_Human1.25584962
66* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25411597
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22650528
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22489338
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.22140021
70* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20804424
71* FOXA1_25329375_ChIP-Seq_VCAP_Human1.20804424
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20682002
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.19983408
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16882376
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.15596807
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15579195
77HTT_18923047_ChIP-ChIP_STHdh_Human1.14887105
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.14129322
79EWS_26573619_Chip-Seq_HEK293_Human1.14039876
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13989481
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13908396
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12626131
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12626131
84NCOR_22424771_ChIP-Seq_293T_Human1.12549897
85RUNX2_22187159_ChIP-Seq_PCA_Human1.12225466
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11613080
87CDX2_20551321_ChIP-Seq_CACO-2_Human1.11421427
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07395006
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.06866409
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06445416
91TP53_18474530_ChIP-ChIP_U2OS_Human1.05722086
92AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04823326
93P53_22387025_ChIP-Seq_ESCs_Mouse1.04222705
94CJUN_26792858_Chip-Seq_BT549_Human1.02841724
95TP53_22573176_ChIP-Seq_HFKS_Human1.02823473
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02780306
97TP53_16413492_ChIP-PET_HCT116_Human1.01881076
98* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01725686
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.01338487
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01035093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.54766177
2MP0008875_abnormal_xenobiotic_pharmacok6.49055008
3MP0005360_urolithiasis5.74115154
4MP0005085_abnormal_gallbladder_physiolo5.25614457
5MP0003195_calcinosis5.23218463
6MP0005365_abnormal_bile_salt4.73637236
7MP0003252_abnormal_bile_duct3.87715384
8MP0002138_abnormal_hepatobiliary_system3.46920015
9MP0001666_abnormal_nutrient_absorption2.72311453
10MP0002876_abnormal_thyroid_physiology2.44454014
11MP0010329_abnormal_lipoprotein_level2.41039586
12MP0003806_abnormal_nucleotide_metabolis2.35062660
13MP0005332_abnormal_amino_acid2.32305577
14MP0009697_abnormal_copulation2.27363876
15MP0003868_abnormal_feces_composition2.07111306
16MP0004019_abnormal_vitamin_homeostasis2.05679406
17MP0004043_abnormal_pH_regulation1.96509249
18MP0008872_abnormal_physiological_respon1.84966948
19MP0001764_abnormal_homeostasis1.68196188
20MP0009840_abnormal_foam_cell1.61873977
21MP0005551_abnormal_eye_electrophysiolog1.43745302
22MP0009780_abnormal_chondrocyte_physiolo1.42065113
23MP0005646_abnormal_pituitary_gland1.41653098
24MP0002118_abnormal_lipid_homeostasis1.35391246
25MP0000383_abnormal_hair_follicle1.31140478
26MP0000609_abnormal_liver_physiology1.24418183
27MP0002736_abnormal_nociception_after1.17042716
28MP0005636_abnormal_mineral_homeostasis1.15778093
29MP0009643_abnormal_urine_homeostasis1.14986269
30MP0003718_maternal_effect1.14856413
31MP0001501_abnormal_sleep_pattern1.13812743
32MP0001968_abnormal_touch/_nociception1.11526766
33MP0010386_abnormal_urinary_bladder1.10173739
34MP0000427_abnormal_hair_cycle1.07809843
35MP0005187_abnormal_penis_morphology1.05750391
36MP0001984_abnormal_olfaction1.04868244
37MP0010678_abnormal_skin_adnexa1.04574333
38MP0005395_other_phenotype1.04555371
39MP0005319_abnormal_enzyme/_coenzyme1.04082134
40MP0003191_abnormal_cellular_cholesterol1.03052331
41MP0009764_decreased_sensitivity_to0.94990091
42MP0003646_muscle_fatigue0.94473535
43MP0003011_delayed_dark_adaptation0.93358749
44MP0002168_other_aberrant_phenotype0.88693329
45MP0002234_abnormal_pharynx_morphology0.87298378
46MP0005645_abnormal_hypothalamus_physiol0.87294055
47MP0002928_abnormal_bile_duct0.85763513
48MP0002653_abnormal_ependyma_morphology0.85328479
49MP0002909_abnormal_adrenal_gland0.83216169
50MP0001661_extended_life_span0.81408138
51MP0003186_abnormal_redox_activity0.80165509
52MP0005670_abnormal_white_adipose0.78995653
53MP0005083_abnormal_biliary_tract0.76351188
54MP0005408_hypopigmentation0.75190575
55MP0002282_abnormal_trachea_morphology0.74118598
56MP0004782_abnormal_surfactant_physiolog0.73956473
57MP0000569_abnormal_digit_pigmentation0.71127689
58MP0005253_abnormal_eye_physiology0.70313457
59MP0009642_abnormal_blood_homeostasis0.69748200
60MP0001756_abnormal_urination0.69472388
61MP0004147_increased_porphyrin_level0.69462995
62MP0002098_abnormal_vibrissa_morphology0.67764659
63MP0003656_abnormal_erythrocyte_physiolo0.67040591
64MP0002102_abnormal_ear_morphology0.66912567
65MP0000538_abnormal_urinary_bladder0.65028716
66MP0005376_homeostasis/metabolism_phenot0.64850643
67MP0009745_abnormal_behavioral_response0.63869038
68MP0004133_heterotaxia0.62916056
69MP0005584_abnormal_enzyme/coenzyme_acti0.62727731
70MP0000647_abnormal_sebaceous_gland0.62094289
71MP0005167_abnormal_blood-brain_barrier0.61140071
72MP0009046_muscle_twitch0.60951328
73MP0001765_abnormal_ion_homeostasis0.60168216
74MP0006276_abnormal_autonomic_nervous0.59899912
75MP0001986_abnormal_taste_sensitivity0.59512000
76MP0002136_abnormal_kidney_physiology0.59438313
77MP0003638_abnormal_response/metabolism_0.58653427
78MP0002078_abnormal_glucose_homeostasis0.58219586
79MP0002160_abnormal_reproductive_system0.57628587
80MP0005386_behavior/neurological_phenoty0.56563696
81MP0004924_abnormal_behavior0.56563696
82MP0000566_synostosis0.55956394
83MP0000598_abnormal_liver_morphology0.53632286
84MP0000372_irregular_coat_pigmentation0.53014767
85MP0010368_abnormal_lymphatic_system0.52681225
86MP0003950_abnormal_plasma_membrane0.52532843
87MP0001529_abnormal_vocalization0.51855920
88MP0008469_abnormal_protein_level0.51614841
89MP0003943_abnormal_hepatobiliary_system0.50472479
90MP0005448_abnormal_energy_balance0.50323548
91MP0001485_abnormal_pinna_reflex0.49688870
92MP0003953_abnormal_hormone_level0.49320268
93MP0005266_abnormal_metabolism0.48680323
94MP0002272_abnormal_nervous_system0.48286060
95MP0005220_abnormal_exocrine_pancreas0.48103603
96MP0002132_abnormal_respiratory_system0.48087916
97MP0005410_abnormal_fertilization0.47696266
98MP0005647_abnormal_sex_gland0.47457037
99MP0002837_dystrophic_cardiac_calcinosis0.46800730
100MP0002971_abnormal_brown_adipose0.46396975

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)6.41695325
2Complement deficiency (HP:0004431)5.68887058
3Prolonged partial thromboplastin time (HP:0003645)5.53537113
4Conjugated hyperbilirubinemia (HP:0002908)5.27302313
5Hypobetalipoproteinemia (HP:0003563)5.13681861
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.96201579
7Deep venous thrombosis (HP:0002625)4.80221473
8Abnormality of complement system (HP:0005339)4.22373492
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01541991
10Intrahepatic cholestasis (HP:0001406)3.73738215
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.50588723
12Absent/shortened dynein arms (HP:0200106)3.50588723
13Glomerulonephritis (HP:0000099)3.37729965
14Joint hemorrhage (HP:0005261)3.19051754
15Hyperglycinuria (HP:0003108)3.18650817
16Hyperlipoproteinemia (HP:0010980)3.12814590
17Abnormality of glycine metabolism (HP:0010895)3.11069064
18Abnormality of serine family amino acid metabolism (HP:0010894)3.11069064
19Fair hair (HP:0002286)3.08368676
20Systemic lupus erythematosus (HP:0002725)3.08255795
21Pancreatic cysts (HP:0001737)3.06746751
22Xanthomatosis (HP:0000991)3.00775882
23Abnormality of proline metabolism (HP:0010907)2.97918830
24Hydroxyprolinuria (HP:0003080)2.97918830
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.95836207
26Abnormal respiratory epithelium morphology (HP:0012253)2.95823094
27Abnormal respiratory motile cilium morphology (HP:0005938)2.95823094
28Abnormality of aspartate family amino acid metabolism (HP:0010899)2.94978954
29Fat malabsorption (HP:0002630)2.94904921
30Generalized aminoaciduria (HP:0002909)2.92539946
31Abnormality of pyrimidine metabolism (HP:0004353)2.87388989
32Spontaneous abortion (HP:0005268)2.83958451
33Epidermoid cyst (HP:0200040)2.83788963
34Hyperglycinemia (HP:0002154)2.80724866
35Decreased central vision (HP:0007663)2.79663025
36Abnormal ciliary motility (HP:0012262)2.75586100
37Abnormality of the renal cortex (HP:0011035)2.73040910
38Vascular calcification (HP:0004934)2.72430327
39Abnormal respiratory motile cilium physiology (HP:0012261)2.71480158
40Hypolipoproteinemia (HP:0010981)2.67399191
41True hermaphroditism (HP:0010459)2.63862626
42Chronic hepatic failure (HP:0100626)2.59878349
43Abnormality of serum amino acid levels (HP:0003112)2.59435903
44Hyperammonemia (HP:0001987)2.55658617
45Pancreatic fibrosis (HP:0100732)2.52277361
46Bile duct proliferation (HP:0001408)2.48184179
47Abnormal biliary tract physiology (HP:0012439)2.48184179
48Abnormality of the common coagulation pathway (HP:0010990)2.41748620
49Abnormality of methionine metabolism (HP:0010901)2.41256822
50Ketosis (HP:0001946)2.37724952
51Generalized hypopigmentation of hair (HP:0011358)2.37633754
52Attenuation of retinal blood vessels (HP:0007843)2.37498148
53Renal cortical cysts (HP:0000803)2.36988348
54Congenital stationary night blindness (HP:0007642)2.36858661
55Steatorrhea (HP:0002570)2.36779662
56Nephritis (HP:0000123)2.35937361
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.31335866
58Rhinitis (HP:0012384)2.30107197
59Abnormality of the intrinsic pathway (HP:0010989)2.29950566
60Rickets (HP:0002748)2.28901919
61Delayed CNS myelination (HP:0002188)2.28702619
62Hypothermia (HP:0002045)2.26989017
63Hypophosphatemic rickets (HP:0004912)2.25680751
64Abnormality of alanine metabolism (HP:0010916)2.25072584
65Hyperalaninemia (HP:0003348)2.25072584
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25072584
67Abolished electroretinogram (ERG) (HP:0000550)2.24162401
68Metabolic acidosis (HP:0001942)2.22100364
69Abnormality of vitamin metabolism (HP:0100508)2.21842064
70Cardiovascular calcification (HP:0011915)2.20317378
71Hyperventilation (HP:0002883)2.19167358
72Tubular atrophy (HP:0000092)2.16021449
73Abnormality of midbrain morphology (HP:0002418)2.15183811
74Molar tooth sign on MRI (HP:0002419)2.15183811
75Glycosuria (HP:0003076)2.15145486
76Abnormality of urine glucose concentration (HP:0011016)2.15145486
77Cystic liver disease (HP:0006706)2.13906209
78Abnormality of macular pigmentation (HP:0008002)2.12056641
79Abnormality of sulfur amino acid metabolism (HP:0004339)2.07779423
80Chronic bronchitis (HP:0004469)2.02294910
81Arthropathy (HP:0003040)2.01679775
82Nephronophthisis (HP:0000090)2.01454567
83Abnormality of the renal medulla (HP:0100957)2.01197675
84Decreased circulating renin level (HP:0003351)1.99444098
85Ketoacidosis (HP:0001993)1.99308308
86Alkalosis (HP:0001948)1.96266861
87Mitral stenosis (HP:0001718)1.95763542
88Enlarged kidneys (HP:0000105)1.94334193
89Keratoconus (HP:0000563)1.92028388
90Increased corneal curvature (HP:0100692)1.92028388
91Recurrent gram-negative bacterial infections (HP:0005420)1.86691643
92Lethargy (HP:0001254)1.85477055
93Hepatocellular carcinoma (HP:0001402)1.82843518
94Chorioretinal atrophy (HP:0000533)1.80798445
95Hyperbilirubinemia (HP:0002904)1.79583481
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76112137
97Medial flaring of the eyebrow (HP:0010747)1.75501520
98Congenital hepatic fibrosis (HP:0002612)1.74989634
99Facial shape deformation (HP:0011334)1.72136961
100Potter facies (HP:0002009)1.72136961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.31931748
2ADRBK22.86268091
3ACVR1B2.71027902
4MAP4K22.69227266
5MST1R2.55789597
6BMPR1B2.39339601
7STK392.33333862
8MST42.23599664
9WNK32.21305688
10WNK42.21183978
11GRK12.17908138
12EIF2AK32.05710668
13EPHA22.04110596
14PINK12.01742142
15BCR1.90868574
16FER1.73696966
17TAOK31.73075112
18OXSR11.66449225
19MET1.62620703
20MUSK1.61270126
21MAPKAPK31.60831710
22ZAK1.60101997
23TLK11.57973294
24TRIM281.56331879
25INSRR1.53578528
26NUAK11.50930683
27PIK3CA1.49668803
28ERBB31.47786578
29PRKCE1.38682043
30LMTK21.28550941
31MAPK131.27168868
32MAP3K41.27144263
33IRAK11.19170746
34STK38L1.15318390
35CASK1.11795326
36PAK31.09650673
37DAPK21.05444487
38EPHA41.03792427
39PRKAA21.00669120
40EPHA30.97406581
41ADRBK10.91843961
42BRSK20.91701819
43TXK0.89330769
44LATS10.88526768
45ERBB40.87837943
46FLT30.86546682
47MAP2K70.84657059
48CSNK1A1L0.79055573
49PBK0.78603193
50PRKCI0.78527661
51CSNK1G10.78194419
52PHKG20.76373367
53PHKG10.76373367
54MAP2K60.76303034
55ERBB20.75920189
56NTRK30.75613767
57CAMKK20.74827173
58PRKCG0.72140537
59IGF1R0.70981570
60CSNK1G30.66429190
61NEK60.66169816
62BCKDK0.65643911
63PRKG20.64655065
64TGFBR10.64475366
65MAP2K10.62437495
66MAP3K20.61670494
67PTK2B0.60788437
68FGFR20.60747465
69NEK10.58653315
70PRKCZ0.58290183
71CSNK1G20.57334999
72STK380.56341293
73MAP3K120.55991695
74IKBKB0.55500968
75TRPM70.54221646
76MAPK150.53934945
77PRKACG0.53409608
78MAP2K40.52035101
79CAMK2A0.51984663
80PRKAA10.51971846
81TIE10.50879684
82CHUK0.49588256
83FGFR30.48350368
84EIF2AK10.47620807
85PRKACA0.46217429
86CSNK1A10.44882636
87CAMK2D0.44628196
88PRKCA0.44440247
89CSNK1D0.42457409
90MAP2K20.39964984
91PLK20.39933809
92PIK3CG0.39052056
93PRKCH0.38427549
94ABL10.38180780
95CAMK2B0.37875582
96MAPK110.36887960
97PRKCQ0.34259643
98SIK30.33871026
99PRKG10.33097809
100RPS6KB10.32446270

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.92417907
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.63505633
3Caffeine metabolism_Homo sapiens_hsa002323.53234571
4Retinol metabolism_Homo sapiens_hsa008303.30786385
5Chemical carcinogenesis_Homo sapiens_hsa052043.30645302
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.23322530
7Pentose and glucuronate interconversions_Homo sapiens_hsa000403.15960753
8Steroid hormone biosynthesis_Homo sapiens_hsa001403.04305332
9Primary bile acid biosynthesis_Homo sapiens_hsa001203.01643915
10Complement and coagulation cascades_Homo sapiens_hsa046102.74119463
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58139362
12Histidine metabolism_Homo sapiens_hsa003402.49792777
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.41917557
14Phenylalanine metabolism_Homo sapiens_hsa003602.24651701
15Linoleic acid metabolism_Homo sapiens_hsa005912.20216586
16Tyrosine metabolism_Homo sapiens_hsa003502.08192818
17Tryptophan metabolism_Homo sapiens_hsa003802.08139044
18Butanoate metabolism_Homo sapiens_hsa006502.03106091
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97257915
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.96571936
21Fatty acid degradation_Homo sapiens_hsa000711.94234946
22Arginine biosynthesis_Homo sapiens_hsa002201.78325537
23Starch and sucrose metabolism_Homo sapiens_hsa005001.70200263
24beta-Alanine metabolism_Homo sapiens_hsa004101.65650698
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65284043
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.62636321
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55521700
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55328146
29Bile secretion_Homo sapiens_hsa049761.50330985
30ABC transporters_Homo sapiens_hsa020101.50253871
31Arachidonic acid metabolism_Homo sapiens_hsa005901.45062209
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36943670
33Peroxisome_Homo sapiens_hsa041461.31709876
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28941156
35Vitamin B6 metabolism_Homo sapiens_hsa007501.22180583
36Propanoate metabolism_Homo sapiens_hsa006401.13968584
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.11800426
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.10458562
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09809392
40Fat digestion and absorption_Homo sapiens_hsa049751.09514088
41PPAR signaling pathway_Homo sapiens_hsa033201.04993437
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01917051
43Arginine and proline metabolism_Homo sapiens_hsa003300.99741854
44Selenocompound metabolism_Homo sapiens_hsa004500.90993101
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88212573
46Sulfur metabolism_Homo sapiens_hsa009200.83691746
47Nitrogen metabolism_Homo sapiens_hsa009100.82555381
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79153035
49Glycerolipid metabolism_Homo sapiens_hsa005610.77564206
50One carbon pool by folate_Homo sapiens_hsa006700.75824566
51Staphylococcus aureus infection_Homo sapiens_hsa051500.75162164
52Glutathione metabolism_Homo sapiens_hsa004800.74994254
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74185920
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73931511
55Fatty acid metabolism_Homo sapiens_hsa012120.67210062
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65039786
57Pyruvate metabolism_Homo sapiens_hsa006200.64946579
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64131965
59Vitamin digestion and absorption_Homo sapiens_hsa049770.61462040
60Phototransduction_Homo sapiens_hsa047440.58276816
61Ether lipid metabolism_Homo sapiens_hsa005650.58067624
62Metabolic pathways_Homo sapiens_hsa011000.57683443
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48612707
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46379627
65Lysine degradation_Homo sapiens_hsa003100.40242236
66Biosynthesis of amino acids_Homo sapiens_hsa012300.38087183
67Mineral absorption_Homo sapiens_hsa049780.35884911
68Fatty acid biosynthesis_Homo sapiens_hsa000610.34681020
69Sphingolipid metabolism_Homo sapiens_hsa006000.32465222
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31545453
71Carbon metabolism_Homo sapiens_hsa012000.31474465
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30812339
73Serotonergic synapse_Homo sapiens_hsa047260.28194156
74Fructose and mannose metabolism_Homo sapiens_hsa000510.25993353
75Ovarian steroidogenesis_Homo sapiens_hsa049130.24802422
76Nicotine addiction_Homo sapiens_hsa050330.23938919
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23222379
78Olfactory transduction_Homo sapiens_hsa047400.22581619
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.17610953
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16595162
81Taste transduction_Homo sapiens_hsa047420.15742580
82Insulin resistance_Homo sapiens_hsa049310.15095992
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14053121
84Steroid biosynthesis_Homo sapiens_hsa001000.14004651
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.13355839
86Sulfur relay system_Homo sapiens_hsa041220.12811893
87Fatty acid elongation_Homo sapiens_hsa000620.12636243
88Circadian rhythm_Homo sapiens_hsa047100.10787994
89Renin-angiotensin system_Homo sapiens_hsa046140.07165282
90Glucagon signaling pathway_Homo sapiens_hsa049220.07001686
91Galactose metabolism_Homo sapiens_hsa000520.04404056
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04251837
93Prion diseases_Homo sapiens_hsa050200.03917849
94Salivary secretion_Homo sapiens_hsa049700.03022278
95Thyroid hormone synthesis_Homo sapiens_hsa049180.02264330
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.01891063
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.01433606
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01385935
99Insulin secretion_Homo sapiens_hsa04911-0.0058595
100Pertussis_Homo sapiens_hsa05133-0.0030790

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