Rank | Gene Set | Z-score |
---|---|---|
1 | exogenous drug catabolic process (GO:0042738) | 7.76902967 |
2 | drug catabolic process (GO:0042737) | 7.54238739 |
3 | epoxygenase P450 pathway (GO:0019373) | 6.87135779 |
4 | cellular glucuronidation (GO:0052695) | 6.76135155 |
5 | omega-hydroxylase P450 pathway (GO:0097267) | 6.56940011 |
6 | glucuronate metabolic process (GO:0019585) | 6.44937919 |
7 | uronic acid metabolic process (GO:0006063) | 6.44937919 |
8 | polyketide metabolic process (GO:0030638) | 5.90661132 |
9 | doxorubicin metabolic process (GO:0044598) | 5.90661132 |
10 | daunorubicin metabolic process (GO:0044597) | 5.90661132 |
11 | flavonoid metabolic process (GO:0009812) | 5.79952868 |
12 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 5.72896769 |
13 | L-phenylalanine catabolic process (GO:0006559) | 5.72896769 |
14 | drug metabolic process (GO:0017144) | 5.65066518 |
15 | complement activation, alternative pathway (GO:0006957) | 5.43640470 |
16 | regulation of protein activation cascade (GO:2000257) | 5.39998405 |
17 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 5.29004923 |
18 | L-phenylalanine metabolic process (GO:0006558) | 5.29004923 |
19 | glyoxylate metabolic process (GO:0046487) | 5.26807434 |
20 | aminoglycoside antibiotic metabolic process (GO:0030647) | 5.25621121 |
21 | phenylpropanoid metabolic process (GO:0009698) | 5.25019322 |
22 | aromatic amino acid family catabolic process (GO:0009074) | 5.19821638 |
23 | regulation of complement activation (GO:0030449) | 5.14779459 |
24 | ethanol oxidation (GO:0006069) | 5.09353431 |
25 | primary alcohol catabolic process (GO:0034310) | 5.01541131 |
26 | oxidative demethylation (GO:0070989) | 4.93524613 |
27 | regulation of fibrinolysis (GO:0051917) | 4.82232810 |
28 | indole-containing compound catabolic process (GO:0042436) | 4.72643743 |
29 | indolalkylamine catabolic process (GO:0046218) | 4.72643743 |
30 | tryptophan catabolic process (GO:0006569) | 4.72643743 |
31 | bile acid biosynthetic process (GO:0006699) | 4.49929940 |
32 | ethanol metabolic process (GO:0006067) | 4.42686025 |
33 | negative regulation of fibrinolysis (GO:0051918) | 4.42145443 |
34 | bile acid metabolic process (GO:0008206) | 4.35303966 |
35 | regulation of triglyceride catabolic process (GO:0010896) | 4.27732708 |
36 | bile acid and bile salt transport (GO:0015721) | 4.12229116 |
37 | intestinal cholesterol absorption (GO:0030299) | 4.06964681 |
38 | serine family amino acid catabolic process (GO:0009071) | 4.05347319 |
39 | tryptophan metabolic process (GO:0006568) | 3.99572760 |
40 | cysteine metabolic process (GO:0006534) | 3.95125889 |
41 | S-adenosylmethionine metabolic process (GO:0046500) | 3.93077169 |
42 | cellular ketone body metabolic process (GO:0046950) | 3.91413594 |
43 | xenobiotic catabolic process (GO:0042178) | 3.87783907 |
44 | aromatic amino acid family metabolic process (GO:0009072) | 3.75557814 |
45 | tyrosine metabolic process (GO:0006570) | 3.75126587 |
46 | amino-acid betaine metabolic process (GO:0006577) | 3.71816717 |
47 | negative regulation of protein activation cascade (GO:2000258) | 3.70430189 |
48 | alkaloid metabolic process (GO:0009820) | 3.68518996 |
49 | retinoic acid metabolic process (GO:0042573) | 3.67391893 |
50 | indolalkylamine metabolic process (GO:0006586) | 3.65866323 |
51 | drug transmembrane transport (GO:0006855) | 3.65579850 |
52 | fibrinolysis (GO:0042730) | 3.65567479 |
53 | arginine metabolic process (GO:0006525) | 3.65436298 |
54 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.61165958 |
55 | protein carboxylation (GO:0018214) | 3.61165958 |
56 | kynurenine metabolic process (GO:0070189) | 3.60963126 |
57 | negative regulation of cholesterol transport (GO:0032375) | 3.57512058 |
58 | negative regulation of sterol transport (GO:0032372) | 3.57512058 |
59 | blood coagulation, intrinsic pathway (GO:0007597) | 3.55466232 |
60 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.54819760 |
61 | ketone body metabolic process (GO:1902224) | 3.52977056 |
62 | * xenobiotic metabolic process (GO:0006805) | 3.50508932 |
63 | urea metabolic process (GO:0019627) | 3.49020837 |
64 | high-density lipoprotein particle remodeling (GO:0034375) | 3.48888109 |
65 | heme transport (GO:0015886) | 3.46437010 |
66 | benzene-containing compound metabolic process (GO:0042537) | 3.41212658 |
67 | protein activation cascade (GO:0072376) | 3.39442791 |
68 | alpha-amino acid catabolic process (GO:1901606) | 3.37082018 |
69 | response to nitrosative stress (GO:0051409) | 3.34322465 |
70 | reverse cholesterol transport (GO:0043691) | 3.34267459 |
71 | acylglycerol homeostasis (GO:0055090) | 3.33043831 |
72 | triglyceride homeostasis (GO:0070328) | 3.33043831 |
73 | * quinone metabolic process (GO:1901661) | 3.29808033 |
74 | glycine metabolic process (GO:0006544) | 3.28333150 |
75 | complement activation, classical pathway (GO:0006958) | 3.24661357 |
76 | macromolecular complex remodeling (GO:0034367) | 3.24166664 |
77 | plasma lipoprotein particle remodeling (GO:0034369) | 3.24166664 |
78 | protein-lipid complex remodeling (GO:0034368) | 3.24166664 |
79 | amine catabolic process (GO:0009310) | 3.23027879 |
80 | cellular biogenic amine catabolic process (GO:0042402) | 3.23027879 |
81 | L-methionine salvage (GO:0071267) | 3.22883006 |
82 | L-methionine biosynthetic process (GO:0071265) | 3.22883006 |
83 | amino acid salvage (GO:0043102) | 3.22883006 |
84 | serine family amino acid metabolic process (GO:0009069) | 3.21160196 |
85 | retinal metabolic process (GO:0042574) | 3.18748910 |
86 | nitrogen cycle metabolic process (GO:0071941) | 3.16347515 |
87 | imidazole-containing compound metabolic process (GO:0052803) | 3.16026228 |
88 | complement activation (GO:0006956) | 3.15947042 |
89 | acute-phase response (GO:0006953) | 3.15028157 |
90 | negative regulation of complement activation (GO:0045916) | 3.14762498 |
91 | primary alcohol metabolic process (GO:0034308) | 3.13949793 |
92 | regulation of humoral immune response (GO:0002920) | 3.08442326 |
93 | glutamate metabolic process (GO:0006536) | 3.06144722 |
94 | cholesterol efflux (GO:0033344) | 3.02743022 |
95 | sodium-independent organic anion transport (GO:0043252) | 3.01838641 |
96 | phospholipid efflux (GO:0033700) | 3.01203978 |
97 | arginine catabolic process (GO:0006527) | 2.99640913 |
98 | drug transport (GO:0015893) | 2.96825496 |
99 | negative regulation of hemostasis (GO:1900047) | 2.95863255 |
100 | negative regulation of blood coagulation (GO:0030195) | 2.95863255 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 3.98680234 |
2 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 3.64901669 |
3 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.75404155 |
4 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.74312110 |
5 | VDR_22108803_ChIP-Seq_LS180_Human | 2.66077881 |
6 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 2.62448552 |
7 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 2.56784960 |
8 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.50203357 |
9 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.42952957 |
10 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.40878875 |
11 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 2.18064892 |
12 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.13658304 |
13 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.06910044 |
14 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 2.05911439 |
15 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.02145217 |
16 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.95730589 |
17 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.90292376 |
18 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.89495833 |
19 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.86221292 |
20 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.84963372 |
21 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.81460659 |
22 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.77721892 |
23 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.76698267 |
24 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.74193271 |
25 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.70121270 |
26 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.66072589 |
27 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.65559444 |
28 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.57049431 |
29 | STAT3_23295773_ChIP-Seq_U87_Human | 1.56860318 |
30 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.53407814 |
31 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.53407814 |
32 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.49767953 |
33 | P300_19829295_ChIP-Seq_ESCs_Human | 1.48850469 |
34 | FUS_26573619_Chip-Seq_HEK293_Human | 1.47568659 |
35 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.47329050 |
36 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.46640023 |
37 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.44580471 |
38 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 1.42698027 |
39 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.41655667 |
40 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.40798875 |
41 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.40735847 |
42 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.40372463 |
43 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.40294774 |
44 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.37859035 |
45 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.36857355 |
46 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.36630722 |
47 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.36507189 |
48 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.34474420 |
49 | AR_20517297_ChIP-Seq_VCAP_Human | 1.34300140 |
50 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.33826819 |
51 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.33377349 |
52 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.32828927 |
53 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.31668844 |
54 | AR_25329375_ChIP-Seq_VCAP_Human | 1.31555068 |
55 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.31128073 |
56 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.31128073 |
57 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.30639289 |
58 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.29246505 |
59 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.28126607 |
60 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.27687102 |
61 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.27585975 |
62 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.27152683 |
63 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.27057382 |
64 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.26513118 |
65 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.25584962 |
66 | * BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.25411597 |
67 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.22650528 |
68 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.22489338 |
69 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.22140021 |
70 | * FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.20804424 |
71 | * FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.20804424 |
72 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.20682002 |
73 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.19983408 |
74 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.16882376 |
75 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.15596807 |
76 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.15579195 |
77 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.14887105 |
78 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.14129322 |
79 | EWS_26573619_Chip-Seq_HEK293_Human | 1.14039876 |
80 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.13989481 |
81 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.13908396 |
82 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.12626131 |
83 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.12626131 |
84 | NCOR_22424771_ChIP-Seq_293T_Human | 1.12549897 |
85 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.12225466 |
86 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.11613080 |
87 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.11421427 |
88 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.07395006 |
89 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.06866409 |
90 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.06445416 |
91 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.05722086 |
92 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.04823326 |
93 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.04222705 |
94 | CJUN_26792858_Chip-Seq_BT549_Human | 1.02841724 |
95 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.02823473 |
96 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.02780306 |
97 | TP53_16413492_ChIP-PET_HCT116_Human | 1.01881076 |
98 | * GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.01725686 |
99 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.01338487 |
100 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.01035093 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 6.54766177 |
2 | MP0008875_abnormal_xenobiotic_pharmacok | 6.49055008 |
3 | MP0005360_urolithiasis | 5.74115154 |
4 | MP0005085_abnormal_gallbladder_physiolo | 5.25614457 |
5 | MP0003195_calcinosis | 5.23218463 |
6 | MP0005365_abnormal_bile_salt | 4.73637236 |
7 | MP0003252_abnormal_bile_duct | 3.87715384 |
8 | MP0002138_abnormal_hepatobiliary_system | 3.46920015 |
9 | MP0001666_abnormal_nutrient_absorption | 2.72311453 |
10 | MP0002876_abnormal_thyroid_physiology | 2.44454014 |
11 | MP0010329_abnormal_lipoprotein_level | 2.41039586 |
12 | MP0003806_abnormal_nucleotide_metabolis | 2.35062660 |
13 | MP0005332_abnormal_amino_acid | 2.32305577 |
14 | MP0009697_abnormal_copulation | 2.27363876 |
15 | MP0003868_abnormal_feces_composition | 2.07111306 |
16 | MP0004019_abnormal_vitamin_homeostasis | 2.05679406 |
17 | MP0004043_abnormal_pH_regulation | 1.96509249 |
18 | MP0008872_abnormal_physiological_respon | 1.84966948 |
19 | MP0001764_abnormal_homeostasis | 1.68196188 |
20 | MP0009840_abnormal_foam_cell | 1.61873977 |
21 | MP0005551_abnormal_eye_electrophysiolog | 1.43745302 |
22 | MP0009780_abnormal_chondrocyte_physiolo | 1.42065113 |
23 | MP0005646_abnormal_pituitary_gland | 1.41653098 |
24 | MP0002118_abnormal_lipid_homeostasis | 1.35391246 |
25 | MP0000383_abnormal_hair_follicle | 1.31140478 |
26 | MP0000609_abnormal_liver_physiology | 1.24418183 |
27 | MP0002736_abnormal_nociception_after | 1.17042716 |
28 | MP0005636_abnormal_mineral_homeostasis | 1.15778093 |
29 | MP0009643_abnormal_urine_homeostasis | 1.14986269 |
30 | MP0003718_maternal_effect | 1.14856413 |
31 | MP0001501_abnormal_sleep_pattern | 1.13812743 |
32 | MP0001968_abnormal_touch/_nociception | 1.11526766 |
33 | MP0010386_abnormal_urinary_bladder | 1.10173739 |
34 | MP0000427_abnormal_hair_cycle | 1.07809843 |
35 | MP0005187_abnormal_penis_morphology | 1.05750391 |
36 | MP0001984_abnormal_olfaction | 1.04868244 |
37 | MP0010678_abnormal_skin_adnexa | 1.04574333 |
38 | MP0005395_other_phenotype | 1.04555371 |
39 | MP0005319_abnormal_enzyme/_coenzyme | 1.04082134 |
40 | MP0003191_abnormal_cellular_cholesterol | 1.03052331 |
41 | MP0009764_decreased_sensitivity_to | 0.94990091 |
42 | MP0003646_muscle_fatigue | 0.94473535 |
43 | MP0003011_delayed_dark_adaptation | 0.93358749 |
44 | MP0002168_other_aberrant_phenotype | 0.88693329 |
45 | MP0002234_abnormal_pharynx_morphology | 0.87298378 |
46 | MP0005645_abnormal_hypothalamus_physiol | 0.87294055 |
47 | MP0002928_abnormal_bile_duct | 0.85763513 |
48 | MP0002653_abnormal_ependyma_morphology | 0.85328479 |
49 | MP0002909_abnormal_adrenal_gland | 0.83216169 |
50 | MP0001661_extended_life_span | 0.81408138 |
51 | MP0003186_abnormal_redox_activity | 0.80165509 |
52 | MP0005670_abnormal_white_adipose | 0.78995653 |
53 | MP0005083_abnormal_biliary_tract | 0.76351188 |
54 | MP0005408_hypopigmentation | 0.75190575 |
55 | MP0002282_abnormal_trachea_morphology | 0.74118598 |
56 | MP0004782_abnormal_surfactant_physiolog | 0.73956473 |
57 | MP0000569_abnormal_digit_pigmentation | 0.71127689 |
58 | MP0005253_abnormal_eye_physiology | 0.70313457 |
59 | MP0009642_abnormal_blood_homeostasis | 0.69748200 |
60 | MP0001756_abnormal_urination | 0.69472388 |
61 | MP0004147_increased_porphyrin_level | 0.69462995 |
62 | MP0002098_abnormal_vibrissa_morphology | 0.67764659 |
63 | MP0003656_abnormal_erythrocyte_physiolo | 0.67040591 |
64 | MP0002102_abnormal_ear_morphology | 0.66912567 |
65 | MP0000538_abnormal_urinary_bladder | 0.65028716 |
66 | MP0005376_homeostasis/metabolism_phenot | 0.64850643 |
67 | MP0009745_abnormal_behavioral_response | 0.63869038 |
68 | MP0004133_heterotaxia | 0.62916056 |
69 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.62727731 |
70 | MP0000647_abnormal_sebaceous_gland | 0.62094289 |
71 | MP0005167_abnormal_blood-brain_barrier | 0.61140071 |
72 | MP0009046_muscle_twitch | 0.60951328 |
73 | MP0001765_abnormal_ion_homeostasis | 0.60168216 |
74 | MP0006276_abnormal_autonomic_nervous | 0.59899912 |
75 | MP0001986_abnormal_taste_sensitivity | 0.59512000 |
76 | MP0002136_abnormal_kidney_physiology | 0.59438313 |
77 | MP0003638_abnormal_response/metabolism_ | 0.58653427 |
78 | MP0002078_abnormal_glucose_homeostasis | 0.58219586 |
79 | MP0002160_abnormal_reproductive_system | 0.57628587 |
80 | MP0005386_behavior/neurological_phenoty | 0.56563696 |
81 | MP0004924_abnormal_behavior | 0.56563696 |
82 | MP0000566_synostosis | 0.55956394 |
83 | MP0000598_abnormal_liver_morphology | 0.53632286 |
84 | MP0000372_irregular_coat_pigmentation | 0.53014767 |
85 | MP0010368_abnormal_lymphatic_system | 0.52681225 |
86 | MP0003950_abnormal_plasma_membrane | 0.52532843 |
87 | MP0001529_abnormal_vocalization | 0.51855920 |
88 | MP0008469_abnormal_protein_level | 0.51614841 |
89 | MP0003943_abnormal_hepatobiliary_system | 0.50472479 |
90 | MP0005448_abnormal_energy_balance | 0.50323548 |
91 | MP0001485_abnormal_pinna_reflex | 0.49688870 |
92 | MP0003953_abnormal_hormone_level | 0.49320268 |
93 | MP0005266_abnormal_metabolism | 0.48680323 |
94 | MP0002272_abnormal_nervous_system | 0.48286060 |
95 | MP0005220_abnormal_exocrine_pancreas | 0.48103603 |
96 | MP0002132_abnormal_respiratory_system | 0.48087916 |
97 | MP0005410_abnormal_fertilization | 0.47696266 |
98 | MP0005647_abnormal_sex_gland | 0.47457037 |
99 | MP0002837_dystrophic_cardiac_calcinosis | 0.46800730 |
100 | MP0002971_abnormal_brown_adipose | 0.46396975 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.41695325 |
2 | Complement deficiency (HP:0004431) | 5.68887058 |
3 | Prolonged partial thromboplastin time (HP:0003645) | 5.53537113 |
4 | Conjugated hyperbilirubinemia (HP:0002908) | 5.27302313 |
5 | Hypobetalipoproteinemia (HP:0003563) | 5.13681861 |
6 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 4.96201579 |
7 | Deep venous thrombosis (HP:0002625) | 4.80221473 |
8 | Abnormality of complement system (HP:0005339) | 4.22373492 |
9 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.01541991 |
10 | Intrahepatic cholestasis (HP:0001406) | 3.73738215 |
11 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.50588723 |
12 | Absent/shortened dynein arms (HP:0200106) | 3.50588723 |
13 | Glomerulonephritis (HP:0000099) | 3.37729965 |
14 | Joint hemorrhage (HP:0005261) | 3.19051754 |
15 | Hyperglycinuria (HP:0003108) | 3.18650817 |
16 | Hyperlipoproteinemia (HP:0010980) | 3.12814590 |
17 | Abnormality of glycine metabolism (HP:0010895) | 3.11069064 |
18 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.11069064 |
19 | Fair hair (HP:0002286) | 3.08368676 |
20 | Systemic lupus erythematosus (HP:0002725) | 3.08255795 |
21 | Pancreatic cysts (HP:0001737) | 3.06746751 |
22 | Xanthomatosis (HP:0000991) | 3.00775882 |
23 | Abnormality of proline metabolism (HP:0010907) | 2.97918830 |
24 | Hydroxyprolinuria (HP:0003080) | 2.97918830 |
25 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.95836207 |
26 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.95823094 |
27 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.95823094 |
28 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.94978954 |
29 | Fat malabsorption (HP:0002630) | 2.94904921 |
30 | Generalized aminoaciduria (HP:0002909) | 2.92539946 |
31 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.87388989 |
32 | Spontaneous abortion (HP:0005268) | 2.83958451 |
33 | Epidermoid cyst (HP:0200040) | 2.83788963 |
34 | Hyperglycinemia (HP:0002154) | 2.80724866 |
35 | Decreased central vision (HP:0007663) | 2.79663025 |
36 | Abnormal ciliary motility (HP:0012262) | 2.75586100 |
37 | Abnormality of the renal cortex (HP:0011035) | 2.73040910 |
38 | Vascular calcification (HP:0004934) | 2.72430327 |
39 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.71480158 |
40 | Hypolipoproteinemia (HP:0010981) | 2.67399191 |
41 | True hermaphroditism (HP:0010459) | 2.63862626 |
42 | Chronic hepatic failure (HP:0100626) | 2.59878349 |
43 | Abnormality of serum amino acid levels (HP:0003112) | 2.59435903 |
44 | Hyperammonemia (HP:0001987) | 2.55658617 |
45 | Pancreatic fibrosis (HP:0100732) | 2.52277361 |
46 | Bile duct proliferation (HP:0001408) | 2.48184179 |
47 | Abnormal biliary tract physiology (HP:0012439) | 2.48184179 |
48 | Abnormality of the common coagulation pathway (HP:0010990) | 2.41748620 |
49 | Abnormality of methionine metabolism (HP:0010901) | 2.41256822 |
50 | Ketosis (HP:0001946) | 2.37724952 |
51 | Generalized hypopigmentation of hair (HP:0011358) | 2.37633754 |
52 | Attenuation of retinal blood vessels (HP:0007843) | 2.37498148 |
53 | Renal cortical cysts (HP:0000803) | 2.36988348 |
54 | Congenital stationary night blindness (HP:0007642) | 2.36858661 |
55 | Steatorrhea (HP:0002570) | 2.36779662 |
56 | Nephritis (HP:0000123) | 2.35937361 |
57 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.31335866 |
58 | Rhinitis (HP:0012384) | 2.30107197 |
59 | Abnormality of the intrinsic pathway (HP:0010989) | 2.29950566 |
60 | Rickets (HP:0002748) | 2.28901919 |
61 | Delayed CNS myelination (HP:0002188) | 2.28702619 |
62 | Hypothermia (HP:0002045) | 2.26989017 |
63 | Hypophosphatemic rickets (HP:0004912) | 2.25680751 |
64 | Abnormality of alanine metabolism (HP:0010916) | 2.25072584 |
65 | Hyperalaninemia (HP:0003348) | 2.25072584 |
66 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.25072584 |
67 | Abolished electroretinogram (ERG) (HP:0000550) | 2.24162401 |
68 | Metabolic acidosis (HP:0001942) | 2.22100364 |
69 | Abnormality of vitamin metabolism (HP:0100508) | 2.21842064 |
70 | Cardiovascular calcification (HP:0011915) | 2.20317378 |
71 | Hyperventilation (HP:0002883) | 2.19167358 |
72 | Tubular atrophy (HP:0000092) | 2.16021449 |
73 | Abnormality of midbrain morphology (HP:0002418) | 2.15183811 |
74 | Molar tooth sign on MRI (HP:0002419) | 2.15183811 |
75 | Glycosuria (HP:0003076) | 2.15145486 |
76 | Abnormality of urine glucose concentration (HP:0011016) | 2.15145486 |
77 | Cystic liver disease (HP:0006706) | 2.13906209 |
78 | Abnormality of macular pigmentation (HP:0008002) | 2.12056641 |
79 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.07779423 |
80 | Chronic bronchitis (HP:0004469) | 2.02294910 |
81 | Arthropathy (HP:0003040) | 2.01679775 |
82 | Nephronophthisis (HP:0000090) | 2.01454567 |
83 | Abnormality of the renal medulla (HP:0100957) | 2.01197675 |
84 | Decreased circulating renin level (HP:0003351) | 1.99444098 |
85 | Ketoacidosis (HP:0001993) | 1.99308308 |
86 | Alkalosis (HP:0001948) | 1.96266861 |
87 | Mitral stenosis (HP:0001718) | 1.95763542 |
88 | Enlarged kidneys (HP:0000105) | 1.94334193 |
89 | Keratoconus (HP:0000563) | 1.92028388 |
90 | Increased corneal curvature (HP:0100692) | 1.92028388 |
91 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.86691643 |
92 | Lethargy (HP:0001254) | 1.85477055 |
93 | Hepatocellular carcinoma (HP:0001402) | 1.82843518 |
94 | Chorioretinal atrophy (HP:0000533) | 1.80798445 |
95 | Hyperbilirubinemia (HP:0002904) | 1.79583481 |
96 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.76112137 |
97 | Medial flaring of the eyebrow (HP:0010747) | 1.75501520 |
98 | Congenital hepatic fibrosis (HP:0002612) | 1.74989634 |
99 | Facial shape deformation (HP:0011334) | 1.72136961 |
100 | Potter facies (HP:0002009) | 1.72136961 |
Rank | Gene Set | Z-score |
---|---|---|
1 | FRK | 6.31931748 |
2 | ADRBK2 | 2.86268091 |
3 | ACVR1B | 2.71027902 |
4 | MAP4K2 | 2.69227266 |
5 | MST1R | 2.55789597 |
6 | BMPR1B | 2.39339601 |
7 | STK39 | 2.33333862 |
8 | MST4 | 2.23599664 |
9 | WNK3 | 2.21305688 |
10 | WNK4 | 2.21183978 |
11 | GRK1 | 2.17908138 |
12 | EIF2AK3 | 2.05710668 |
13 | EPHA2 | 2.04110596 |
14 | PINK1 | 2.01742142 |
15 | BCR | 1.90868574 |
16 | FER | 1.73696966 |
17 | TAOK3 | 1.73075112 |
18 | OXSR1 | 1.66449225 |
19 | MET | 1.62620703 |
20 | MUSK | 1.61270126 |
21 | MAPKAPK3 | 1.60831710 |
22 | ZAK | 1.60101997 |
23 | TLK1 | 1.57973294 |
24 | TRIM28 | 1.56331879 |
25 | INSRR | 1.53578528 |
26 | NUAK1 | 1.50930683 |
27 | PIK3CA | 1.49668803 |
28 | ERBB3 | 1.47786578 |
29 | PRKCE | 1.38682043 |
30 | LMTK2 | 1.28550941 |
31 | MAPK13 | 1.27168868 |
32 | MAP3K4 | 1.27144263 |
33 | IRAK1 | 1.19170746 |
34 | STK38L | 1.15318390 |
35 | CASK | 1.11795326 |
36 | PAK3 | 1.09650673 |
37 | DAPK2 | 1.05444487 |
38 | EPHA4 | 1.03792427 |
39 | PRKAA2 | 1.00669120 |
40 | EPHA3 | 0.97406581 |
41 | ADRBK1 | 0.91843961 |
42 | BRSK2 | 0.91701819 |
43 | TXK | 0.89330769 |
44 | LATS1 | 0.88526768 |
45 | ERBB4 | 0.87837943 |
46 | FLT3 | 0.86546682 |
47 | MAP2K7 | 0.84657059 |
48 | CSNK1A1L | 0.79055573 |
49 | PBK | 0.78603193 |
50 | PRKCI | 0.78527661 |
51 | CSNK1G1 | 0.78194419 |
52 | PHKG2 | 0.76373367 |
53 | PHKG1 | 0.76373367 |
54 | MAP2K6 | 0.76303034 |
55 | ERBB2 | 0.75920189 |
56 | NTRK3 | 0.75613767 |
57 | CAMKK2 | 0.74827173 |
58 | PRKCG | 0.72140537 |
59 | IGF1R | 0.70981570 |
60 | CSNK1G3 | 0.66429190 |
61 | NEK6 | 0.66169816 |
62 | BCKDK | 0.65643911 |
63 | PRKG2 | 0.64655065 |
64 | TGFBR1 | 0.64475366 |
65 | MAP2K1 | 0.62437495 |
66 | MAP3K2 | 0.61670494 |
67 | PTK2B | 0.60788437 |
68 | FGFR2 | 0.60747465 |
69 | NEK1 | 0.58653315 |
70 | PRKCZ | 0.58290183 |
71 | CSNK1G2 | 0.57334999 |
72 | STK38 | 0.56341293 |
73 | MAP3K12 | 0.55991695 |
74 | IKBKB | 0.55500968 |
75 | TRPM7 | 0.54221646 |
76 | MAPK15 | 0.53934945 |
77 | PRKACG | 0.53409608 |
78 | MAP2K4 | 0.52035101 |
79 | CAMK2A | 0.51984663 |
80 | PRKAA1 | 0.51971846 |
81 | TIE1 | 0.50879684 |
82 | CHUK | 0.49588256 |
83 | FGFR3 | 0.48350368 |
84 | EIF2AK1 | 0.47620807 |
85 | PRKACA | 0.46217429 |
86 | CSNK1A1 | 0.44882636 |
87 | CAMK2D | 0.44628196 |
88 | PRKCA | 0.44440247 |
89 | CSNK1D | 0.42457409 |
90 | MAP2K2 | 0.39964984 |
91 | PLK2 | 0.39933809 |
92 | PIK3CG | 0.39052056 |
93 | PRKCH | 0.38427549 |
94 | ABL1 | 0.38180780 |
95 | CAMK2B | 0.37875582 |
96 | MAPK11 | 0.36887960 |
97 | PRKCQ | 0.34259643 |
98 | SIK3 | 0.33871026 |
99 | PRKG1 | 0.33097809 |
100 | RPS6KB1 | 0.32446270 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.92417907 |
2 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 3.63505633 |
3 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.53234571 |
4 | Retinol metabolism_Homo sapiens_hsa00830 | 3.30786385 |
5 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 3.30645302 |
6 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 3.23322530 |
7 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 3.15960753 |
8 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 3.04305332 |
9 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.01643915 |
10 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.74119463 |
11 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.58139362 |
12 | Histidine metabolism_Homo sapiens_hsa00340 | 2.49792777 |
13 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 2.41917557 |
14 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 2.24651701 |
15 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.20216586 |
16 | Tyrosine metabolism_Homo sapiens_hsa00350 | 2.08192818 |
17 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.08139044 |
18 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.03106091 |
19 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.97257915 |
20 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.96571936 |
21 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.94234946 |
22 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.78325537 |
23 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.70200263 |
24 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.65650698 |
25 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.65284043 |
26 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.62636321 |
27 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.55521700 |
28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.55328146 |
29 | Bile secretion_Homo sapiens_hsa04976 | 1.50330985 |
30 | ABC transporters_Homo sapiens_hsa02010 | 1.50253871 |
31 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.45062209 |
32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.36943670 |
33 | Peroxisome_Homo sapiens_hsa04146 | 1.31709876 |
34 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.28941156 |
35 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.22180583 |
36 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.13968584 |
37 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.11800426 |
38 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.10458562 |
39 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.09809392 |
40 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.09514088 |
41 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.04993437 |
42 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.01917051 |
43 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.99741854 |
44 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.90993101 |
45 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.88212573 |
46 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.83691746 |
47 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.82555381 |
48 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.79153035 |
49 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.77564206 |
50 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.75824566 |
51 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.75162164 |
52 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.74994254 |
53 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.74185920 |
54 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.73931511 |
55 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.67210062 |
56 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.65039786 |
57 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.64946579 |
58 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.64131965 |
59 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.61462040 |
60 | Phototransduction_Homo sapiens_hsa04744 | 0.58276816 |
61 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.58067624 |
62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.57683443 |
63 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.48612707 |
64 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.46379627 |
65 | Lysine degradation_Homo sapiens_hsa00310 | 0.40242236 |
66 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.38087183 |
67 | Mineral absorption_Homo sapiens_hsa04978 | 0.35884911 |
68 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.34681020 |
69 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.32465222 |
70 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.31545453 |
71 | Carbon metabolism_Homo sapiens_hsa01200 | 0.31474465 |
72 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.30812339 |
73 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.28194156 |
74 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.25993353 |
75 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.24802422 |
76 | Nicotine addiction_Homo sapiens_hsa05033 | 0.23938919 |
77 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.23222379 |
78 | Olfactory transduction_Homo sapiens_hsa04740 | 0.22581619 |
79 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.17610953 |
80 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.16595162 |
81 | Taste transduction_Homo sapiens_hsa04742 | 0.15742580 |
82 | Insulin resistance_Homo sapiens_hsa04931 | 0.15095992 |
83 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.14053121 |
84 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.14004651 |
85 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.13355839 |
86 | Sulfur relay system_Homo sapiens_hsa04122 | 0.12811893 |
87 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.12636243 |
88 | Circadian rhythm_Homo sapiens_hsa04710 | 0.10787994 |
89 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.07165282 |
90 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.07001686 |
91 | Galactose metabolism_Homo sapiens_hsa00052 | 0.04404056 |
92 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.04251837 |
93 | Prion diseases_Homo sapiens_hsa05020 | 0.03917849 |
94 | Salivary secretion_Homo sapiens_hsa04970 | 0.03022278 |
95 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.02264330 |
96 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.01891063 |
97 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.01433606 |
98 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.01385935 |
99 | Insulin secretion_Homo sapiens_hsa04911 | -0.0058595 |
100 | Pertussis_Homo sapiens_hsa05133 | -0.0030790 |