CYP4F12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* epoxygenase P450 pathway (GO:0019373)6.43214181
2angiotensin maturation (GO:0002003)6.28422121
3exogenous drug catabolic process (GO:0042738)6.22815586
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.03578771
5drug catabolic process (GO:0042737)6.00496214
6ethanol oxidation (GO:0006069)5.71829975
7intestinal absorption (GO:0050892)5.66906861
8cellular glucuronidation (GO:0052695)5.50117712
9very-low-density lipoprotein particle assembly (GO:0034379)5.44493077
10glucuronate metabolic process (GO:0019585)5.29069790
11uronic acid metabolic process (GO:0006063)5.29069790
12* drug metabolic process (GO:0017144)5.13903855
13urea metabolic process (GO:0019627)5.10849444
14regulation of triglyceride catabolic process (GO:0010896)5.02050994
15NADH metabolic process (GO:0006734)4.89954190
16plasma lipoprotein particle assembly (GO:0034377)4.83649950
17omega-hydroxylase P450 pathway (GO:0097267)4.83181245
18bile acid and bile salt transport (GO:0015721)4.78815908
19urea cycle (GO:0000050)4.78121064
20ethanol metabolic process (GO:0006067)4.67079832
21nitrogen cycle metabolic process (GO:0071941)4.66784539
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.57663110
23regulation of bile acid biosynthetic process (GO:0070857)4.54737054
24phospholipid efflux (GO:0033700)4.54690260
25flavonoid metabolic process (GO:0009812)4.53189427
26regulation of fibrinolysis (GO:0051917)4.51737903
27positive regulation of lipoprotein lipase activity (GO:0051006)4.50585360
28positive regulation of triglyceride lipase activity (GO:0061365)4.50585360
29negative regulation of fibrinolysis (GO:0051918)4.47621400
30diacylglycerol metabolic process (GO:0046339)4.45875112
31regulation of cholesterol esterification (GO:0010872)4.44254810
32regulation of protein activation cascade (GO:2000257)4.42350959
33hormone catabolic process (GO:0042447)4.41543790
34fructose metabolic process (GO:0006000)4.37537968
35regulation of guanylate cyclase activity (GO:0031282)4.33648128
36protein-lipid complex assembly (GO:0065005)4.32311592
37plasma lipoprotein particle remodeling (GO:0034369)4.31804470
38protein-lipid complex remodeling (GO:0034368)4.31804470
39macromolecular complex remodeling (GO:0034367)4.31804470
40regulation of complement activation (GO:0030449)4.29729118
41lipoprotein transport (GO:0042953)4.27298446
42bile acid metabolic process (GO:0008206)4.21800177
43complement activation, alternative pathway (GO:0006957)4.18888596
44high-density lipoprotein particle remodeling (GO:0034375)4.17267885
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.08136901
46cholesterol efflux (GO:0033344)4.01508072
47alkaloid metabolic process (GO:0009820)4.00446992
48plasma lipoprotein particle organization (GO:0071827)3.95746350
49negative regulation of sterol transport (GO:0032372)3.88373801
50negative regulation of cholesterol transport (GO:0032375)3.88373801
51lipoprotein metabolic process (GO:0042157)3.86785902
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.82468670
53L-phenylalanine catabolic process (GO:0006559)3.82468670
54* fat-soluble vitamin biosynthetic process (GO:0042362)3.77833215
55reverse cholesterol transport (GO:0043691)3.76581446
56positive regulation of lipid catabolic process (GO:0050996)3.74892244
57protein-lipid complex subunit organization (GO:0071825)3.73071100
58regulation of systemic arterial blood pressure by hormone (GO:0001990)3.72364780
59regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.72364780
60endocrine process (GO:0050886)3.72364780
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.71564033
62L-phenylalanine metabolic process (GO:0006558)3.71564033
63regulation of cholesterol homeostasis (GO:2000188)3.66859900
64peptidyl-glutamic acid carboxylation (GO:0017187)3.66549433
65protein carboxylation (GO:0018214)3.66549433
66complement activation, classical pathway (GO:0006958)3.64619212
67intestinal cholesterol absorption (GO:0030299)3.59391074
68phenylpropanoid metabolic process (GO:0009698)3.57834859
69arginine metabolic process (GO:0006525)3.54269717
70low-density lipoprotein particle remodeling (GO:0034374)3.53611768
71positive regulation of fatty acid biosynthetic process (GO:0045723)3.47943463
72glyoxylate metabolic process (GO:0046487)3.45182775
73drug transport (GO:0015893)3.40101643
74vitamin transmembrane transport (GO:0035461)3.38946439
75drug transmembrane transport (GO:0006855)3.38727959
76protein activation cascade (GO:0072376)3.38531473
77acylglycerol homeostasis (GO:0055090)3.35740941
78triglyceride homeostasis (GO:0070328)3.35740941
79complement activation (GO:0006956)3.32223459
80maintenance of gastrointestinal epithelium (GO:0030277)3.32090784
81cholesterol homeostasis (GO:0042632)3.29577567
82fibrinolysis (GO:0042730)3.26947928
83proline metabolic process (GO:0006560)3.25069825
84sterol homeostasis (GO:0055092)3.23766494
85regulation of systemic arterial blood pressure (GO:0003073)3.22858979
86blood coagulation, intrinsic pathway (GO:0007597)3.17283413
87acute-phase response (GO:0006953)3.16945721
88glutamine family amino acid biosynthetic process (GO:0009084)3.15501654
89primary alcohol catabolic process (GO:0034310)3.15492113
90regulation of cholesterol metabolic process (GO:0090181)3.12329971
91* negative regulation of blood coagulation (GO:0030195)3.06433725
92* negative regulation of hemostasis (GO:1900047)3.06433725
93primary alcohol metabolic process (GO:0034308)3.05094255
94oxidative demethylation (GO:0070989)3.02363309
95positive regulation of guanylate cyclase activity (GO:0031284)3.01088465
96bile acid biosynthetic process (GO:0006699)2.97888089
97oxaloacetate metabolic process (GO:0006107)2.96688182
98glutamate metabolic process (GO:0006536)2.94979699
99* xenobiotic metabolic process (GO:0006805)2.90574651
100peptide catabolic process (GO:0043171)2.90455914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.75761083
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.47274445
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.00857675
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.77822820
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.69091989
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.66424594
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.63947193
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.29453131
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86248739
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.66639254
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.39201304
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.33056151
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.28707033
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.26463406
15* GATA4_25053715_ChIP-Seq_YYC3_Human2.22704822
16GATA6_25053715_ChIP-Seq_YYC3_Human2.04725758
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.96959819
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94914794
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.88929577
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.87722744
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81655161
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.78852276
23SOX2_20726797_ChIP-Seq_SW620_Human1.78797036
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69033377
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.68497681
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67777438
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62381596
28LXR_22292898_ChIP-Seq_THP-1_Human1.62317210
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.57682143
30GATA1_22025678_ChIP-Seq_K562_Human1.54520865
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45298254
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.44903439
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44063217
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.40090453
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38891107
36AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.38730899
37CLOCK_20551151_ChIP-Seq_293T_Human1.37698594
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.37443778
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.36218181
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31644371
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28585475
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.22423893
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22134255
44P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20513413
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20034775
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.19851614
47FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.16676964
48RACK7_27058665_Chip-Seq_MCF-7_Human1.16069534
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12482137
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11507233
51BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10606817
52ZNF263_19887448_ChIP-Seq_K562_Human1.09229299
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07375957
54* FOXA1_25552417_ChIP-Seq_VCAP_Human1.04688833
55BCOR_27268052_Chip-Seq_Bcells_Human1.04259932
56BCL6_27268052_Chip-Seq_Bcells_Human1.01818838
57CEBPB_22108803_ChIP-Seq_LS180_Human1.01425489
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00828303
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98835899
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96611644
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96236227
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95316042
63SA1_27219007_Chip-Seq_Bcells_Human0.94986244
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93128623
65GATA1_19941826_ChIP-Seq_K562_Human0.91359942
66GATA2_19941826_ChIP-Seq_K562_Human0.89802999
67DROSHA_22980978_ChIP-Seq_HELA_Human0.89747584
68RUNX1_27514584_Chip-Seq_MCF-7_Human0.89560432
69KLF5_25053715_ChIP-Seq_YYC3_Human0.89516856
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88726136
71RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88724205
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88418449
73SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88373468
74JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87482749
75DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87423749
76CTCF_27219007_Chip-Seq_Bcells_Human0.86925463
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86223578
78CDX2_22108803_ChIP-Seq_LS180_Human0.85647791
79TET1_21451524_ChIP-Seq_MESCs_Mouse0.84077935
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81980819
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.81379471
82ESR1_20079471_ChIP-ChIP_T-47D_Human0.79200134
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79038515
84IRF8_21731497_ChIP-ChIP_J774_Mouse0.78760752
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78500950
86TP63_22573176_ChIP-Seq_HFKS_Human0.78388165
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78166826
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76607893
89GATA1_19941827_ChIP-Seq_MEL_Mouse0.75785360
90GATA3_24758297_ChIP-Seq_MCF-7_Human0.75562694
91E2F1_20622854_ChIP-Seq_HELA_Human0.75467401
92SMC4_20622854_ChIP-Seq_HELA_Human0.75411780
93NANOG_20526341_ChIP-Seq_ESCs_Human0.75328825
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74040336
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73901810
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73366971
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73073616
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71929161
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71908372
100PHF8_20622854_ChIP-Seq_HELA_Human0.70756057

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.96221073
2MP0002139_abnormal_hepatobiliary_system7.24859613
3MP0005085_abnormal_gallbladder_physiolo5.28429553
4MP0005365_abnormal_bile_salt4.89088589
5MP0001666_abnormal_nutrient_absorption4.44187978
6MP0008875_abnormal_xenobiotic_pharmacok3.11009231
7MP0010329_abnormal_lipoprotein_level3.00238067
8MP0009840_abnormal_foam_cell2.95616784
9MP0003183_abnormal_peptide_metabolism2.84886026
10MP0004019_abnormal_vitamin_homeostasis2.78601783
11MP0003252_abnormal_bile_duct2.68001873
12MP0003868_abnormal_feces_composition2.45034362
13MP0003195_calcinosis2.40342749
14MP0010234_abnormal_vibrissa_follicle2.38540997
15MP0004264_abnormal_extraembryonic_tissu2.25224403
16MP0005332_abnormal_amino_acid2.17583635
17MP0005670_abnormal_white_adipose1.93203354
18MP0002138_abnormal_hepatobiliary_system1.93106097
19MP0010155_abnormal_intestine_physiology1.88181075
20MP0003191_abnormal_cellular_cholesterol1.82216748
21MP0002118_abnormal_lipid_homeostasis1.71819717
22MP0009379_abnormal_foot_pigmentation1.71575285
23MP0009643_abnormal_urine_homeostasis1.70794539
24MP0002876_abnormal_thyroid_physiology1.63723452
25MP0000609_abnormal_liver_physiology1.61709618
26MP0005409_darkened_coat_color1.59908193
27MP0004147_increased_porphyrin_level1.54584275
28MP0001764_abnormal_homeostasis1.50994700
29MP0003866_abnormal_defecation1.50184826
30MP0005451_abnormal_body_composition1.50140690
31MP0003806_abnormal_nucleotide_metabolis1.45526843
32MP0005636_abnormal_mineral_homeostasis1.35770755
33MP0001664_abnormal_digestion1.32642163
34MP0004043_abnormal_pH_regulation1.30809773
35MP0000566_synostosis1.21776963
36MP0002971_abnormal_brown_adipose1.20871874
37MP0003879_abnormal_hair_cell1.20270966
38MP0001765_abnormal_ion_homeostasis1.18743145
39MP0005319_abnormal_enzyme/_coenzyme1.13990406
40MP0005166_decreased_susceptibility_to1.12456945
41MP0005584_abnormal_enzyme/coenzyme_acti1.05402180
42MP0000678_abnormal_parathyroid_gland1.04882198
43MP0002136_abnormal_kidney_physiology1.02096545
44MP0001756_abnormal_urination0.99158343
45MP0000477_abnormal_intestine_morphology0.98156781
46MP0004782_abnormal_surfactant_physiolog0.93279057
47MP0010352_gastrointestinal_tract_polyps0.93187255
48MP0005448_abnormal_energy_balance0.92251742
49MP0002796_impaired_skin_barrier0.91047692
50MP0009642_abnormal_blood_homeostasis0.90407912
51MP0001663_abnormal_digestive_system0.89129850
52MP0002132_abnormal_respiratory_system0.88494033
53MP0008469_abnormal_protein_level0.87587895
54MP0005058_abnormal_lysosome_morphology0.87025223
55MP0005666_abnormal_adipose_tissue0.83388458
56MP0005535_abnormal_body_temperature0.83001855
57MP0009115_abnormal_fat_cell0.82627683
58MP0003724_increased_susceptibility_to0.80528809
59MP0000490_abnormal_crypts_of0.77984471
60MP0009785_altered_susceptibility_to0.77007723
61MP0000538_abnormal_urinary_bladder0.75764307
62MP0003436_decreased_susceptibility_to0.72333627
63MP0001873_stomach_inflammation0.71322759
64MP0002078_abnormal_glucose_homeostasis0.70097859
65MP0002166_altered_tumor_susceptibility0.68889607
66MP0001845_abnormal_inflammatory_respons0.68546293
67MP0002098_abnormal_vibrissa_morphology0.68361436
68MP0005381_digestive/alimentary_phenotyp0.68025018
69MP0000598_abnormal_liver_morphology0.67954907
70MP0008872_abnormal_physiological_respon0.67345208
71MP0005408_hypopigmentation0.65652136
72MP0004858_abnormal_nervous_system0.65425687
73MP0000249_abnormal_blood_vessel0.64642735
74MP0005334_abnormal_fat_pad0.62857440
75MP0000604_amyloidosis0.62476488
76MP0003638_abnormal_response/metabolism_0.60161223
77MP0005025_abnormal_response_to0.59135254
78MP0005376_homeostasis/metabolism_phenot0.58852919
79MP0003303_peritoneal_inflammation0.58183352
80MP0009780_abnormal_chondrocyte_physiolo0.57659604
81MP0009764_decreased_sensitivity_to0.56825421
82MP0000465_gastrointestinal_hemorrhage0.55305631
83MP0003172_abnormal_lysosome_physiology0.54965665
84MP0003953_abnormal_hormone_level0.53378162
85MP0000230_abnormal_systemic_arterial0.52416557
86MP0009763_increased_sensitivity_to0.51786641
87MP0003718_maternal_effect0.50413629
88MP0005501_abnormal_skin_physiology0.49167865
89MP0001501_abnormal_sleep_pattern0.48652390
90MP0002822_catalepsy0.48538448
91MP0005464_abnormal_platelet_physiology0.47430526
92MP0000462_abnormal_digestive_system0.46904589
93MP0002089_abnormal_postnatal_growth/wei0.46895085
94MP0004947_skin_inflammation0.45681792
95MP0003300_gastrointestinal_ulcer0.45474807
96MP0009697_abnormal_copulation0.44994022
97MP0003075_altered_response_to0.44118658
98MP0005375_adipose_tissue_phenotype0.41399312
99MP0001533_abnormal_skeleton_physiology0.41383468
100MP0009333_abnormal_splenocyte_physiolog0.40394880

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.45101408
2Hypobetalipoproteinemia (HP:0003563)6.70581901
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.49099860
4Deep venous thrombosis (HP:0002625)5.79264597
5Complement deficiency (HP:0004431)5.70445497
6Systemic lupus erythematosus (HP:0002725)5.60313467
7Abnormality of proline metabolism (HP:0010907)5.16490075
8Hydroxyprolinuria (HP:0003080)5.16490075
9Abnormality of complement system (HP:0005339)4.84692395
10Malnutrition (HP:0004395)4.75501684
11Prolonged partial thromboplastin time (HP:0003645)4.72650790
12Xanthomatosis (HP:0000991)4.66312073
13Fat malabsorption (HP:0002630)4.30295828
14Abnormality of aromatic amino acid family metabolism (HP:0004338)4.24708429
15Conjugated hyperbilirubinemia (HP:0002908)4.12567375
16Hemorrhage of the eye (HP:0011885)4.08626755
17Glomerulonephritis (HP:0000099)4.02230775
18Hypolipoproteinemia (HP:0010981)3.78737073
19Joint hemorrhage (HP:0005261)3.70270857
20Widely patent fontanelles and sutures (HP:0004492)3.57340043
21Hyperglycinuria (HP:0003108)3.55581277
22Acanthocytosis (HP:0001927)3.47551793
23Intrahepatic cholestasis (HP:0001406)3.36752389
24Abnormality of serine family amino acid metabolism (HP:0010894)3.35554443
25Abnormality of glycine metabolism (HP:0010895)3.35554443
26Ileus (HP:0002595)3.22169786
27Abnormality of vitamin metabolism (HP:0100508)3.22084802
28Hyperactive renin-angiotensin system (HP:0000841)3.19301591
29Hyperlipoproteinemia (HP:0010980)3.14211223
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.06354091
31Chronic diarrhea (HP:0002028)3.04813110
32Abnormality of the vitamin B12 metabolism (HP:0004341)2.99852876
33Nephritis (HP:0000123)2.99267493
34Hyperammonemia (HP:0001987)2.92441514
35Decreased circulating renin level (HP:0003351)2.91125477
36Steatorrhea (HP:0002570)2.89140997
37Alkalosis (HP:0001948)2.86565407
38Epidermoid cyst (HP:0200040)2.84667269
39Abnormality of vitamin B metabolism (HP:0004340)2.84199468
40Abnormality of pyrimidine metabolism (HP:0004353)2.83189160
41Abnormality of urine glucose concentration (HP:0011016)2.81167632
42Glycosuria (HP:0003076)2.81167632
43Pigmentary retinal degeneration (HP:0001146)2.80685080
44Confusion (HP:0001289)2.71692742
45Proximal tubulopathy (HP:0000114)2.70353721
46Potter facies (HP:0002009)2.65138096
47Facial shape deformation (HP:0011334)2.65138096
48Vascular calcification (HP:0004934)2.58847324
49Recurrent gram-negative bacterial infections (HP:0005420)2.54265329
50Abnormality of the common coagulation pathway (HP:0010990)2.52522866
51Metabolic alkalosis (HP:0200114)2.50849610
52Hypophosphatemia (HP:0002148)2.50372031
53Rickets (HP:0002748)2.50227342
54Wide cranial sutures (HP:0010537)2.47787125
55Hypercholesterolemia (HP:0003124)2.47009563
56Flat acetabular roof (HP:0003180)2.43110359
57Nausea (HP:0002018)2.41084715
58Abdominal distention (HP:0003270)2.39416090
59Abnormality of renin-angiotensin system (HP:0000847)2.35451635
60Abnormality of nucleobase metabolism (HP:0010932)2.34806303
61Eczematoid dermatitis (HP:0000976)2.32078168
62Nephrolithiasis (HP:0000787)2.29502437
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24935396
64Megaloblastic anemia (HP:0001889)2.22268108
65Cardiovascular calcification (HP:0011915)2.21030821
66Hypotension (HP:0002615)2.20976637
67Spontaneous abortion (HP:0005268)2.18950680
68Delayed CNS myelination (HP:0002188)2.18448048
69Metabolic acidosis (HP:0001942)2.18296846
70Gingival bleeding (HP:0000225)2.18000336
71Thin bony cortex (HP:0002753)2.17838909
72Poikilocytosis (HP:0004447)2.17726681
73Hyperphosphaturia (HP:0003109)2.16065833
74Abnormal urine phosphate concentration (HP:0012599)2.12888767
75Abnormality of purine metabolism (HP:0004352)2.12630827
76Increased purine levels (HP:0004368)2.09467303
77Hyperuricemia (HP:0002149)2.09467303
78Generalized aminoaciduria (HP:0002909)2.09447456
79Focal segmental glomerulosclerosis (HP:0000097)2.07637678
80Cerebral palsy (HP:0100021)2.02287516
81Amyloidosis (HP:0011034)2.00847086
82Hyperglycinemia (HP:0002154)2.00825738
83Hypophosphatemic rickets (HP:0004912)2.00670224
84Purpura (HP:0000979)1.99452542
85Abnormal tarsal ossification (HP:0008369)1.97504072
86Congenital sensorineural hearing impairment (HP:0008527)1.96821221
87Right ventricular cardiomyopathy (HP:0011663)1.96635699
88Skin nodule (HP:0200036)1.95332532
89Abnormal enzyme/coenzyme activity (HP:0012379)1.90777944
90Hypoalphalipoproteinemia (HP:0003233)1.88714887
91Pancreatitis (HP:0001733)1.88555683
92Gout (HP:0001997)1.87957165
93Abnormality of alkaline phosphatase activity (HP:0004379)1.86559447
94Abnormality of sulfur amino acid metabolism (HP:0004339)1.81185560
95Irritability (HP:0000737)1.80620727
96Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80344089
97Dicarboxylic aciduria (HP:0003215)1.80344089
98Hepatocellular carcinoma (HP:0001402)1.79847925
99Glomerulosclerosis (HP:0000096)1.78048042
100Hyperbilirubinemia (HP:0002904)1.74715314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.00799987
2ERN14.96688932
3ACVR1B4.88597542
4RIPK13.74631943
5FGFR43.65578620
6EPHA23.33830507
7PRKG22.54893982
8FGFR32.41653715
9PIK3CA2.32849525
10TYK21.98152300
11MAP3K21.90427356
12MET1.84083060
13PTK61.71487811
14EPHA31.66413925
15GRK61.56071932
16EPHB11.50508364
17PRKAA21.33343782
18MAP4K11.31956227
19LMTK21.29465340
20TRIB31.27556415
21STK391.23222974
22DYRK1B1.21980130
23MAP3K11.21691851
24SIK11.21407718
25PDPK11.19288530
26MAP3K31.17528213
27DDR21.14963315
28AKT31.14266270
29ERBB21.10323240
30MAPK111.08744756
31MAP3K101.08705733
32RIPK41.03318584
33STK241.01758569
34TAOK11.00772885
35MATK0.97379904
36FER0.96709480
37MAP2K60.95559308
38MAP2K20.92867698
39NLK0.90229125
40CDC42BPA0.87475405
41MAP3K120.86634240
42PDK10.85550929
43ICK0.83951240
44MYLK0.80865015
45MAP3K110.79108689
46PRKACG0.78986275
47MAPKAPK30.77915784
48OXSR10.77633394
49RET0.76964664
50PRPF4B0.76228314
51TBK10.75723007
52PDK20.72402270
53CSK0.71972353
54TESK20.71970228
55IRAK10.71032831
56EPHB20.69739759
57JAK10.68670416
58ZAP700.68150001
59PRKCZ0.67156930
60PDGFRA0.62259089
61EPHA40.62047224
62MAP3K70.61519647
63SMG10.59952067
64WNK40.59054069
65MAP3K60.58828367
66MST40.58384011
67JAK20.57115944
68TGFBR20.55075950
69CSF1R0.54249458
70FGR0.52956108
71YES10.52934193
72SRC0.48652042
73FRK0.47058087
74BLK0.45577481
75IRAK40.43866638
76KSR20.42698781
77IGF1R0.42340300
78IKBKE0.42215957
79FGFR20.41572601
80TESK10.40770258
81PRKCA0.39784776
82FYN0.38855649
83CDK60.38108210
84EEF2K0.35776671
85PRKAA10.34537561
86LATS10.32903473
87PTK20.32722027
88MAP2K30.30420793
89FGFR10.29644569
90JAK30.29131742
91ABL20.28395438
92BMX0.28036892
93DAPK20.27622425
94MAPKAPK20.27306369
95LYN0.25873052
96CAMK2D0.25767631
97MAP2K40.25701915
98SYK0.24797725
99TNK20.24592817
100IRAK30.24212525

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.74192835
2Caffeine metabolism_Homo sapiens_hsa002323.36376605
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18160753
4Fat digestion and absorption_Homo sapiens_hsa049753.10940120
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.89261557
6Retinol metabolism_Homo sapiens_hsa008302.83286430
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71188927
8Histidine metabolism_Homo sapiens_hsa003402.69872738
9Chemical carcinogenesis_Homo sapiens_hsa052042.66746807
10Arginine biosynthesis_Homo sapiens_hsa002202.58872602
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.56697334
12Vitamin digestion and absorption_Homo sapiens_hsa049772.53149263
13Complement and coagulation cascades_Homo sapiens_hsa046102.33795387
14Fatty acid degradation_Homo sapiens_hsa000712.28584741
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.28344286
16Renin-angiotensin system_Homo sapiens_hsa046142.22946320
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.15238920
18Starch and sucrose metabolism_Homo sapiens_hsa005002.13013785
19PPAR signaling pathway_Homo sapiens_hsa033202.01347364
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.99441108
21Phenylalanine metabolism_Homo sapiens_hsa003601.98752610
22Bile secretion_Homo sapiens_hsa049761.89971420
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84834628
24Linoleic acid metabolism_Homo sapiens_hsa005911.84658071
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69863850
26Tryptophan metabolism_Homo sapiens_hsa003801.60240664
27Mineral absorption_Homo sapiens_hsa049781.59841759
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58706490
29Tyrosine metabolism_Homo sapiens_hsa003501.57796551
30Sulfur metabolism_Homo sapiens_hsa009201.44711930
31Fructose and mannose metabolism_Homo sapiens_hsa000511.42286829
32Arachidonic acid metabolism_Homo sapiens_hsa005901.37683384
33Arginine and proline metabolism_Homo sapiens_hsa003301.30496220
34Staphylococcus aureus infection_Homo sapiens_hsa051501.30271420
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27630692
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.26152769
37Butanoate metabolism_Homo sapiens_hsa006501.25075862
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20736044
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19381281
40Glycerolipid metabolism_Homo sapiens_hsa005611.15782032
41Protein digestion and absorption_Homo sapiens_hsa049741.10056188
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04979358
43Galactose metabolism_Homo sapiens_hsa000521.01928876
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97572948
45Peroxisome_Homo sapiens_hsa041460.97395272
46Fatty acid metabolism_Homo sapiens_hsa012120.97334024
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95309684
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94485326
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93676831
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92164816
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87109262
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85568212
53ABC transporters_Homo sapiens_hsa020100.81416158
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77861371
55Other glycan degradation_Homo sapiens_hsa005110.75984904
56beta-Alanine metabolism_Homo sapiens_hsa004100.69190613
57Pyruvate metabolism_Homo sapiens_hsa006200.67100948
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65604008
59Glutathione metabolism_Homo sapiens_hsa004800.61145791
60Fatty acid biosynthesis_Homo sapiens_hsa000610.58027046
61Biosynthesis of amino acids_Homo sapiens_hsa012300.57663759
62Propanoate metabolism_Homo sapiens_hsa006400.54438390
63Carbon metabolism_Homo sapiens_hsa012000.51189414
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.51116210
65Ether lipid metabolism_Homo sapiens_hsa005650.50455658
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49055841
67Insulin resistance_Homo sapiens_hsa049310.47147603
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45391767
69Sulfur relay system_Homo sapiens_hsa041220.44009328
70Vitamin B6 metabolism_Homo sapiens_hsa007500.42955489
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.40661469
72Sphingolipid metabolism_Homo sapiens_hsa006000.37794679
73Nitrogen metabolism_Homo sapiens_hsa009100.33672691
74Pertussis_Homo sapiens_hsa051330.32386796
75Metabolic pathways_Homo sapiens_hsa011000.31226750
76Pentose phosphate pathway_Homo sapiens_hsa000300.31061851
77Asthma_Homo sapiens_hsa053100.27133444
78Prion diseases_Homo sapiens_hsa050200.25953567
79Pancreatic secretion_Homo sapiens_hsa049720.25653323
80Glucagon signaling pathway_Homo sapiens_hsa049220.24153636
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.18760704
82Fatty acid elongation_Homo sapiens_hsa000620.18154421
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.16836898
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15988115
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13538561
86Renin secretion_Homo sapiens_hsa049240.13488828
87Allograft rejection_Homo sapiens_hsa053300.13178489
88AMPK signaling pathway_Homo sapiens_hsa041520.12947002
89Thyroid hormone synthesis_Homo sapiens_hsa049180.12372079
90Autoimmune thyroid disease_Homo sapiens_hsa053200.10531534
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.09824406
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09280976
93Hepatitis C_Homo sapiens_hsa051600.07561991
94Graft-versus-host disease_Homo sapiens_hsa053320.06409121
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05690552
96Folate biosynthesis_Homo sapiens_hsa007900.04815712
97African trypanosomiasis_Homo sapiens_hsa051430.04328416
98Lysine degradation_Homo sapiens_hsa003100.00669982
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130-0.0071506
100Type I diabetes mellitus_Homo sapiens_hsa04940-0.0052885

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