CYP4F22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.68017887
2keratinocyte differentiation (GO:0030216)8.43133357
3sphingosine metabolic process (GO:0006670)8.32772604
4hair cycle (GO:0042633)8.06311746
5molting cycle (GO:0042303)8.06311746
6diol metabolic process (GO:0034311)8.05824323
7sphingoid metabolic process (GO:0046519)7.70299512
8multicellular organismal water homeostasis (GO:0050891)7.51101996
9epidermal cell differentiation (GO:0009913)6.49412388
10peptide cross-linking (GO:0018149)6.42260228
11water homeostasis (GO:0030104)6.21809918
12linoleic acid metabolic process (GO:0043651)6.04697222
13detection of bacterium (GO:0016045)5.55106606
14epidermis development (GO:0008544)5.49868073
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.23955377
16lipoxygenase pathway (GO:0019372)5.23359630
17phosphatidylserine acyl-chain remodeling (GO:0036150)5.20876984
18phosphatidylinositol acyl-chain remodeling (GO:0036149)5.08212703
19detection of other organism (GO:0098543)5.07523961
20keratinocyte proliferation (GO:0043616)4.99371269
21long-chain fatty acid biosynthetic process (GO:0042759)4.70267649
22regulation of natural killer cell differentiation (GO:0032823)4.43422545
23phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.30640988
24intermediate filament organization (GO:0045109)4.22067788
25response to phenylpropanoid (GO:0080184)4.21831638
26L-phenylalanine catabolic process (GO:0006559)4.02332104
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.02332104
28skin morphogenesis (GO:0043589)3.98288531
29protein-chromophore linkage (GO:0018298)3.96972106
30negative regulation of glycoprotein biosynthetic process (GO:0010561)3.90329408
31negative regulation of interferon-gamma production (GO:0032689)3.86036441
32L-phenylalanine metabolic process (GO:0006558)3.78782385
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.78782385
34phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.73320730
35phosphatidylcholine acyl-chain remodeling (GO:0036151)3.71090099
36intermediate filament cytoskeleton organization (GO:0045104)3.51075469
37detection of external biotic stimulus (GO:0098581)3.42385396
38fibrinolysis (GO:0042730)3.40686198
39regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.38978984
40tyrosine metabolic process (GO:0006570)3.37184177
41intermediate filament-based process (GO:0045103)3.34093966
42sulfate transmembrane transport (GO:1902358)3.29316000
43phospholipid efflux (GO:0033700)3.28752482
44positive regulation of keratinocyte differentiation (GO:0045618)3.22639767
45phosphatidylserine metabolic process (GO:0006658)3.22628500
46response to mercury ion (GO:0046689)3.15665733
47embryonic process involved in female pregnancy (GO:0060136)3.15625786
48sphingolipid biosynthetic process (GO:0030148)3.13367412
49negative regulation of glycoprotein metabolic process (GO:1903019)3.12865030
50gap junction assembly (GO:0016264)3.10632194
51epithelial cell differentiation involved in prostate gland development (GO:0060742)3.09935222
52one-carbon compound transport (GO:0019755)3.07765472
53DNA methylation involved in gamete generation (GO:0043046)3.07647278
54regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.05877845
55detection of biotic stimulus (GO:0009595)2.98007791
56positive regulation of epidermal cell differentiation (GO:0045606)2.97992412
57negative regulation of stem cell proliferation (GO:2000647)2.94878819
58primary alcohol catabolic process (GO:0034310)2.89126937
59fatty acid elongation (GO:0030497)2.88999283
60CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.85036324
61T-helper cell differentiation (GO:0042093)2.85036324
62ectoderm development (GO:0007398)2.83803323
63positive regulation of epidermis development (GO:0045684)2.82884949
64regulation of protein glycosylation (GO:0060049)2.81994632
65regulation of triglyceride catabolic process (GO:0010896)2.81170557
66flavonoid metabolic process (GO:0009812)2.79473500
67regulation of interleukin-5 production (GO:0032674)2.79239196
68urea metabolic process (GO:0019627)2.72658793
69regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.71923307
70alditol phosphate metabolic process (GO:0052646)2.71245318
71hair follicle morphogenesis (GO:0031069)2.69894413
72regulation of hair follicle development (GO:0051797)2.68628067
73paraxial mesoderm development (GO:0048339)2.68601312
74urea cycle (GO:0000050)2.66346759
75sulfate transport (GO:0008272)2.66096891
76negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.65354977
77regulation of keratinocyte differentiation (GO:0045616)2.65051182
78lipopolysaccharide biosynthetic process (GO:0009103)2.64379699
79ceramide biosynthetic process (GO:0046513)2.61321112
80epoxygenase P450 pathway (GO:0019373)2.58331253
81regulation of keratinocyte proliferation (GO:0010837)2.55599139
82biotin metabolic process (GO:0006768)2.55545865
83membrane lipid biosynthetic process (GO:0046467)2.54689072
84heme transport (GO:0015886)2.54262113
85SMAD protein complex assembly (GO:0007183)2.53506936
86regulation of protein activation cascade (GO:2000257)2.53358479
87hemidesmosome assembly (GO:0031581)2.52486575
88epithelium development (GO:0060429)2.51534034
89regulation of hair cycle (GO:0042634)2.49730683
90positive regulation of monocyte chemotaxis (GO:0090026)2.47375896
91regulation of complement activation (GO:0030449)2.47222062
92defense response to fungus (GO:0050832)2.46968834
93regulation of meiosis I (GO:0060631)2.46808442
94positive regulation of cholesterol efflux (GO:0010875)2.46575782
95phospholipid catabolic process (GO:0009395)2.43213679
96keratinocyte development (GO:0003334)2.41132170
97polarized epithelial cell differentiation (GO:0030859)2.39575553
98keratinization (GO:0031424)15.9029591
99establishment of skin barrier (GO:0061436)12.3951741
100regulation of water loss via skin (GO:0033561)10.9323524

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.96156504
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.58229492
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.50725349
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.44342292
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.27378156
6TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.51074979
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.46804117
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37434951
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.35472007
10AR_21572438_ChIP-Seq_LNCaP_Human2.30405764
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18220165
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13460260
13LXR_22292898_ChIP-Seq_THP-1_Human2.03321246
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00766369
15SOX9_24532713_ChIP-Seq_HFSC_Mouse1.95889614
16RACK7_27058665_Chip-Seq_MCF-7_Human1.90091304
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88632509
18RUNX1_27514584_Chip-Seq_MCF-7_Human1.86455239
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82241012
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81927264
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.78728918
22EGR1_19032775_ChIP-ChIP_M12_Human1.78548607
23TP63_22573176_ChIP-Seq_HFKS_Human1.76247997
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65954557
25SMC4_20622854_ChIP-Seq_HELA_Human1.65061443
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56400533
27CTCF_27219007_Chip-Seq_Bcells_Human1.55944239
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.47441165
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47300300
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47300300
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45001922
32E2F1_20622854_ChIP-Seq_HELA_Human1.44103468
33BCOR_27268052_Chip-Seq_Bcells_Human1.42332799
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40229022
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.38562246
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38406178
37ATF3_27146783_Chip-Seq_COLON_Human1.37411878
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37376935
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35108408
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.34601743
41P68_20966046_ChIP-Seq_HELA_Human1.32640646
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.31798072
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.30677763
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.29507327
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29358372
46GATA3_24758297_ChIP-Seq_MCF-7_Human1.28668608
47ZNF263_19887448_ChIP-Seq_K562_Human1.27371017
48STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.26467350
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25496433
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25429805
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25186897
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24995733
53KLF5_25053715_ChIP-Seq_YYC3_Human1.22693903
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21682898
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16948011
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16314090
57TP63_23658742_ChIP-Seq_EP156T_Human1.14926363
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14566905
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14453020
60SPI1_20517297_ChIP-Seq_HL60_Human1.11651663
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11042258
62TCF7_22412390_ChIP-Seq_EML_Mouse1.11030296
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10613545
64CTCF_20526341_ChIP-Seq_ESCs_Human1.10031817
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09489598
66* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07354419
67JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05758105
68FOXH1_21741376_ChIP-Seq_ESCs_Human1.05174700
69BCL6_27268052_Chip-Seq_Bcells_Human1.05014382
70RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02868980
71STAT1_20625510_ChIP-Seq_HELA_Human1.02226863
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01336884
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99771934
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99598547
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98814152
76RAC3_21632823_ChIP-Seq_H3396_Human0.94599335
77ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94014977
78PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93597546
79CREB1_26743006_Chip-Seq_LNCaP_Human0.91599512
80PHF8_20622854_ChIP-Seq_HELA_Human0.91581401
81RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91452551
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91185866
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90021724
84OCT4_20526341_ChIP-Seq_ESCs_Human0.88530866
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87943965
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87927802
87* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87731301
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87436498
89CEBPB_22108803_ChIP-Seq_LS180_Human0.85920786
90YY1_22570637_ChIP-Seq_MALME-3M_Human0.85015122
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84844844
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.84712056
93AHR_22903824_ChIP-Seq_MCF-7_Human0.84276815
94* P53_21459846_ChIP-Seq_SAOS-2_Human0.84169660
95GATA4_25053715_ChIP-Seq_YYC3_Human0.81500306
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80989829
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79766392
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79413615
99SA1_27219007_Chip-Seq_Bcells_Human0.79375661
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78828572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.81927685
2MP0005275_abnormal_skin_tensile5.16619242
3MP0004381_abnormal_hair_follicle5.00058322
4MP0005501_abnormal_skin_physiology4.32253326
5MP0000579_abnormal_nail_morphology4.22571005
6MP0003705_abnormal_hypodermis_morpholog3.83190214
7MP0010234_abnormal_vibrissa_follicle3.71705918
8MP0002837_dystrophic_cardiac_calcinosis2.96176076
9MP0005171_absent_coat_pigmentation2.77721256
10MP0005377_hearing/vestibular/ear_phenot2.64701197
11MP0003878_abnormal_ear_physiology2.64701197
12MP0003453_abnormal_keratinocyte_physiol2.63806858
13MP0005075_abnormal_melanosome_morpholog2.60730363
14MP0001216_abnormal_epidermal_layer2.56523386
15MP0002098_abnormal_vibrissa_morphology2.48802478
16MP0002060_abnormal_skin_morphology2.48656801
17MP0002653_abnormal_ependyma_morphology2.45074516
18MP0003136_yellow_coat_color2.39257244
19MP0010771_integument_phenotype2.29213615
20MP0000377_abnormal_hair_follicle2.28731833
21MP0000383_abnormal_hair_follicle2.26482640
22MP0010678_abnormal_skin_adnexa2.11488943
23MP0003045_fibrosis2.07143895
24MP0003191_abnormal_cellular_cholesterol2.06186282
25MP0003941_abnormal_skin_development2.05678246
26MP0004947_skin_inflammation2.00604634
27MP0005365_abnormal_bile_salt1.90182220
28MP0009379_abnormal_foot_pigmentation1.82046348
29MP0000467_abnormal_esophagus_morphology1.74106126
30MP0000427_abnormal_hair_cycle1.69467843
31MP0004264_abnormal_extraembryonic_tissu1.68650342
32MP0005085_abnormal_gallbladder_physiolo1.65968522
33MP0000647_abnormal_sebaceous_gland1.65661753
34MP0005409_darkened_coat_color1.57290509
35MP0002095_abnormal_skin_pigmentation1.53175867
36MP0000566_synostosis1.52844185
37MP0002138_abnormal_hepatobiliary_system1.44173399
38MP0000367_abnormal_coat/_hair1.40946302
39MP0009931_abnormal_skin_appearance1.40361812
40MP0003890_abnormal_embryonic-extraembry1.38484025
41MP0003879_abnormal_hair_cell1.32752787
42MP0003646_muscle_fatigue1.31611326
43MP0005076_abnormal_cell_differentiation1.28279605
44MP0009780_abnormal_chondrocyte_physiolo1.24034804
45MP0001188_hyperpigmentation1.20458389
46MP0005670_abnormal_white_adipose1.18898595
47MP0010352_gastrointestinal_tract_polyps1.13580717
48MP0004885_abnormal_endolymph1.06897954
49MP0005360_urolithiasis1.06625874
50MP0005174_abnormal_tail_pigmentation1.01145898
51MP0000015_abnormal_ear_pigmentation1.01023388
52MP0003011_delayed_dark_adaptation1.00131044
53MP0002139_abnormal_hepatobiliary_system0.98289344
54MP0004782_abnormal_surfactant_physiolog0.95224339
55MP0001191_abnormal_skin_condition0.93764965
56MP0009053_abnormal_anal_canal0.89301285
57MP0003566_abnormal_cell_adhesion0.87007099
58MP0001243_abnormal_dermal_layer0.86446755
59MP0003763_abnormal_thymus_physiology0.80605879
60MP0003300_gastrointestinal_ulcer0.79827183
61MP0000465_gastrointestinal_hemorrhage0.78875471
62MP0004185_abnormal_adipocyte_glucose0.77394705
63MP0002168_other_aberrant_phenotype0.76648892
64MP0008875_abnormal_xenobiotic_pharmacok0.75827752
65MP0003195_calcinosis0.70929097
66MP0002254_reproductive_system_inflammat0.69502953
67MP0002075_abnormal_coat/hair_pigmentati0.66513979
68MP0002009_preneoplasia0.65819398
69MP0005666_abnormal_adipose_tissue0.65417778
70MP0000569_abnormal_digit_pigmentation0.64944207
71MP0000762_abnormal_tongue_morphology0.64252937
72MP0001186_pigmentation_phenotype0.59708078
73MP0009840_abnormal_foam_cell0.55380829
74MP0008260_abnormal_autophagy0.53362726
75MP0009333_abnormal_splenocyte_physiolog0.52742457
76MP0010329_abnormal_lipoprotein_level0.47890235
77MP0001851_eye_inflammation0.47561243
78MP0005023_abnormal_wound_healing0.47504383
79MP0004043_abnormal_pH_regulation0.47437783
80MP0009115_abnormal_fat_cell0.46780437
81MP0002971_abnormal_brown_adipose0.45809741
82MP0003638_abnormal_response/metabolism_0.45493824
83MP0001666_abnormal_nutrient_absorption0.44705231
84MP0004233_abnormal_muscle_weight0.44505557
85MP0001661_extended_life_span0.44256579
86MP0002249_abnormal_larynx_morphology0.40738766
87MP0002118_abnormal_lipid_homeostasis0.40268615
88MP0005451_abnormal_body_composition0.38988192
89MP0001784_abnormal_fluid_regulation0.38947597
90MP0005367_renal/urinary_system_phenotyp0.36892661
91MP0000516_abnormal_urinary_system0.36892661
92MP0000534_abnormal_ureter_morphology0.36841548
93MP0005319_abnormal_enzyme/_coenzyme0.36622342
94MP0010030_abnormal_orbit_morphology0.36039809
95MP0003252_abnormal_bile_duct0.32123187
96MP0001340_abnormal_eyelid_morphology0.31852933
97MP0000470_abnormal_stomach_morphology0.31833264
98MP0000627_abnormal_mammary_gland0.31769027
99MP0001756_abnormal_urination0.30874996
100MP0001533_abnormal_skeleton_physiology0.30175782

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)7.98032745
2Palmoplantar hyperkeratosis (HP:0000972)7.72958662
3Palmar hyperkeratosis (HP:0010765)7.27105067
4* Congenital ichthyosiform erythroderma (HP:0007431)6.64044283
5* Erythroderma (HP:0001019)6.30128123
6* Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.24504709
7Plantar hyperkeratosis (HP:0007556)6.17686724
8Hypotrichosis (HP:0001006)6.08474370
9Erythema (HP:0010783)5.90788690
10Onycholysis (HP:0001806)5.23508263
11Oral leukoplakia (HP:0002745)4.97801191
12Alopecia of scalp (HP:0002293)4.93746738
13Amelogenesis imperfecta (HP:0000705)4.90373018
14Thick nail (HP:0001805)4.84524152
15Corneal erosion (HP:0200020)4.67636298
16Woolly hair (HP:0002224)4.66006825
17Conjunctival hamartoma (HP:0100780)4.61942245
18Abnormality of the axillary hair (HP:0100134)4.21044554
19Abnormality of secondary sexual hair (HP:0009888)4.21044554
20* Gangrene (HP:0100758)4.21023600
21* Parakeratosis (HP:0001036)4.19655785
22Right ventricular cardiomyopathy (HP:0011663)4.18374218
23* Palmoplantar keratoderma (HP:0000982)3.95095168
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.92915586
25Hypohidrosis (HP:0000966)3.50849196
26Ectropion (HP:0000656)3.50846535
27Abnormal blistering of the skin (HP:0008066)3.41354223
28Pili torti (HP:0003777)3.39915977
29Nail dystrophy (HP:0008404)3.19552041
30Eczematoid dermatitis (HP:0000976)3.12919623
31Sparse eyelashes (HP:0000653)3.09571484
32Abnormal hair laboratory examination (HP:0003328)2.98991594
33Hamartoma of the eye (HP:0010568)2.87879301
34Lip pit (HP:0100267)2.85369698
35Fragile nails (HP:0001808)2.78014095
36Absent eyelashes (HP:0000561)2.73093662
37Abnormality of the salivary glands (HP:0010286)2.65700373
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.60263360
39* Pruritus (HP:0000989)2.55604001
40Follicular hyperkeratosis (HP:0007502)2.54950364
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48349849
42Pustule (HP:0200039)2.44098897
43Deep venous thrombosis (HP:0002625)2.36793076
44Axonal loss (HP:0003447)2.27681721
45Absent hair (HP:0002298)2.27580623
46Septate vagina (HP:0001153)2.27116270
47* Lack of skin elasticity (HP:0100679)2.17751865
48Sparse scalp hair (HP:0002209)2.17569776
49Furrowed tongue (HP:0000221)2.10044076
50Brittle hair (HP:0002299)2.07345380
51Blepharitis (HP:0000498)2.06501929
52Keratoconjunctivitis sicca (HP:0001097)2.02943658
53Acanthosis nigricans (HP:0000956)2.02384812
54Seborrheic dermatitis (HP:0001051)2.01460466
55Abnormality of nail color (HP:0100643)10.2316608
56* Dehydration (HP:0001944)1.97712819
57Multifactorial inheritance (HP:0001426)1.95997894
58Hypergammaglobulinemia (HP:0010702)1.95231261
59Slow-growing hair (HP:0002217)1.91995780
60Abnormality of hair growth rate (HP:0011363)1.91995780
61Hamartoma (HP:0010566)1.89869611
62Hyperhidrosis (HP:0000975)1.88521376
63Fine hair (HP:0002213)1.88260054
64Complement deficiency (HP:0004431)1.88000485
65Urticaria (HP:0001025)1.85533062
66Natal tooth (HP:0000695)1.83765413
67Laryngomalacia (HP:0001601)1.83344171
68Abnormality of the distal phalanges of the toes (HP:0010182)1.82803895
69Advanced eruption of teeth (HP:0006288)1.82622471
70Focal motor seizures (HP:0011153)1.80198146
71Abnormality of complement system (HP:0005339)1.77096638
72Ridged nail (HP:0001807)1.77020181
73Spontaneous hematomas (HP:0007420)1.76704499
74Keratoconjunctivitis (HP:0001096)1.74659258
75Purpura (HP:0000979)1.74590539
76Neonatal death (HP:0003811)1.72869371
77Esophageal varix (HP:0002040)1.66928903
78Milia (HP:0001056)1.65718660
79Vertebral arch anomaly (HP:0008438)1.59140911
80Selective tooth agenesis (HP:0001592)1.59100219
81Glomerulonephritis (HP:0000099)1.55126800
82Rectal prolapse (HP:0002035)1.53572583
83Melanocytic nevus (HP:0000995)1.53065617
84Skin ulcer (HP:0200042)1.51527005
85Peripheral hypomyelination (HP:0007182)1.50333223
86Segmental peripheral demyelination/remyelination (HP:0003481)1.49506657
87Increased neuronal autofluorescent lipopigment (HP:0002074)1.49296536
88Abnormality of the fingertips (HP:0001211)1.48295184
89Proximal amyotrophy (HP:0007126)1.45986335
90Onion bulb formation (HP:0003383)1.42475484
91Difficulty walking (HP:0002355)1.42079779
92Visceral angiomatosis (HP:0100761)1.41578839
93Deformed sella turcica (HP:0002681)1.41035148
94Hypoplastic labia majora (HP:0000059)1.40184721
95Ulnar claw (HP:0001178)1.39912254
96Craniofacial hyperostosis (HP:0004493)1.37446547
97Duplicated collecting system (HP:0000081)1.37381303
98Paralysis (HP:0003470)1.36997093
99Papilloma (HP:0012740)1.36488308
100Verrucae (HP:0200043)1.36488308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS18.35390560
2LATS25.25892050
3STK38L5.16713113
4NME13.18934858
5EPHA22.80063686
6MAP2K22.78048974
7SIK12.56436422
8STK382.49443795
9PRKD32.47356567
10TRIB32.42007208
11MAP3K22.02639603
12MAPKAPK31.81024463
13EEF2K1.80679204
14MAP3K61.78496776
15NLK1.73274341
16ERN11.64241463
17TGFBR11.60927735
18MELK1.52923086
19STK31.35748163
20ACVR1B1.32025321
21SMG11.31586338
22IRAK31.24493232
23FER1.24391576
24KSR21.19197335
25RPS6KB21.14911490
26RIPK11.13748323
27PDPK11.13494200
28PRPF4B1.03882066
29GRK61.03526411
30TNK21.01641327
31PRKAA21.00600107
32MUSK0.96994992
33MAP3K30.90852823
34PIK3CG0.85760987
35ZAK0.82484730
36TAF10.80545912
37MAP3K10.78076155
38MAP2K10.76946205
39FGFR40.70982063
40MAPK70.70769082
41MAP2K60.70734779
42STK240.69150566
43PRKD10.64682758
44RET0.63335866
45EPHB10.63255866
46RPS6KA20.62284255
47IKBKB0.61566317
48CHUK0.59560646
49ICK0.59302645
50MST1R0.58659342
51FGFR10.55952192
52EPHA30.54713759
53PKN20.53832987
54MAP4K10.53730744
55RPS6KC10.50599794
56RPS6KL10.50599794
57MAP3K70.49498948
58PDGFRA0.49395367
59DYRK1B0.48442930
60PTK60.47308723
61FGFR30.46628373
62JAK10.45479995
63SGK4940.43355007
64SGK2230.43355007
65JAK30.41765735
66RPS6KA60.41197437
67IKBKE0.40284571
68TBK10.40002432
69PRKCI0.39302407
70PRKD20.38904365
71MTOR0.37731250
72HIPK20.36725338
73CDK120.36719562
74MAP2K30.34970430
75RPS6KB10.34874413
76MAPKAPK20.34786914
77IRAK40.34296955
78MARK20.33834455
79NEK60.33625694
80CSK0.33013536
81MAPK30.31197556
82LRRK20.30930339
83EIF2AK20.30719109
84TRPM70.30505153
85RIPK40.30352760
86TAOK10.29920086
87ADRBK10.29590696
88CSF1R0.26920917
89GRK50.26095475
90ZAP700.25534772
91PDGFRB0.23050359
92DAPK20.22885083
93FRK0.22413403
94MAPK120.22410406
95BMX0.22345493
96RPS6KA10.21060131
97STK100.20843303
98GSK3A0.20033143
99MAP3K140.18302290
100NEK20.17688209

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.37338578
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.28801938
3Linoleic acid metabolism_Homo sapiens_hsa005913.77639386
4Sphingolipid metabolism_Homo sapiens_hsa006003.23211392
5Phenylalanine metabolism_Homo sapiens_hsa003602.81260968
6Arachidonic acid metabolism_Homo sapiens_hsa005902.72936753
7Histidine metabolism_Homo sapiens_hsa003402.35709041
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29998153
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.20444327
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14984106
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01424451
12Phototransduction_Homo sapiens_hsa047441.97004101
13VEGF signaling pathway_Homo sapiens_hsa043701.94080943
14Complement and coagulation cascades_Homo sapiens_hsa046101.78763355
15Ether lipid metabolism_Homo sapiens_hsa005651.75818630
16Retinol metabolism_Homo sapiens_hsa008301.69106196
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66797826
18Tyrosine metabolism_Homo sapiens_hsa003501.65191102
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.60089552
20Dorso-ventral axis formation_Homo sapiens_hsa043201.54495023
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50513727
22Staphylococcus aureus infection_Homo sapiens_hsa051501.47490641
23Ovarian steroidogenesis_Homo sapiens_hsa049131.46996041
24Acute myeloid leukemia_Homo sapiens_hsa052211.43448909
25Chemical carcinogenesis_Homo sapiens_hsa052041.31164462
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29673565
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23670503
28Fatty acid elongation_Homo sapiens_hsa000621.22754897
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.20805719
30Thyroid cancer_Homo sapiens_hsa052161.20062727
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.19109720
32Bile secretion_Homo sapiens_hsa049761.16174551
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.08662394
34Fatty acid degradation_Homo sapiens_hsa000711.06367545
35beta-Alanine metabolism_Homo sapiens_hsa004101.05784680
36Sphingolipid signaling pathway_Homo sapiens_hsa040711.04816323
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02398624
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00141529
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98562889
40PPAR signaling pathway_Homo sapiens_hsa033200.98303217
41Fat digestion and absorption_Homo sapiens_hsa049750.96970422
42Tryptophan metabolism_Homo sapiens_hsa003800.91405082
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.89376310
44GnRH signaling pathway_Homo sapiens_hsa049120.88367372
45Arginine biosynthesis_Homo sapiens_hsa002200.88107002
46ABC transporters_Homo sapiens_hsa020100.87794282
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87707120
48Vitamin digestion and absorption_Homo sapiens_hsa049770.79154942
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74705722
50Choline metabolism in cancer_Homo sapiens_hsa052310.74166495
51Serotonergic synapse_Homo sapiens_hsa047260.70986357
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67527417
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64828992
54Bladder cancer_Homo sapiens_hsa052190.63996669
55Sulfur relay system_Homo sapiens_hsa041220.62099205
56Starch and sucrose metabolism_Homo sapiens_hsa005000.60189068
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59483169
58Pertussis_Homo sapiens_hsa051330.54678854
59Amoebiasis_Homo sapiens_hsa051460.54564146
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54233101
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.53192757
62Pancreatic cancer_Homo sapiens_hsa052120.51998744
63Glycerolipid metabolism_Homo sapiens_hsa005610.49747572
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46234484
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46063752
66Platelet activation_Homo sapiens_hsa046110.45572067
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45226123
68Lysine degradation_Homo sapiens_hsa003100.44725319
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44566477
70Chronic myeloid leukemia_Homo sapiens_hsa052200.43648388
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.43046800
72Hepatitis C_Homo sapiens_hsa051600.40999140
73Long-term depression_Homo sapiens_hsa047300.40196625
74Tuberculosis_Homo sapiens_hsa051520.38869988
75Circadian rhythm_Homo sapiens_hsa047100.36489663
76Butanoate metabolism_Homo sapiens_hsa006500.35334366
77Insulin resistance_Homo sapiens_hsa049310.35112995
78Notch signaling pathway_Homo sapiens_hsa043300.34506693
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32999110
80Estrogen signaling pathway_Homo sapiens_hsa049150.32253689
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31840754
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.30433498
83Arginine and proline metabolism_Homo sapiens_hsa003300.29637005
84Insulin signaling pathway_Homo sapiens_hsa049100.29623762
85AMPK signaling pathway_Homo sapiens_hsa041520.29399446
86Inositol phosphate metabolism_Homo sapiens_hsa005620.28850429
87ECM-receptor interaction_Homo sapiens_hsa045120.28584046
88p53 signaling pathway_Homo sapiens_hsa041150.28484280
89Fructose and mannose metabolism_Homo sapiens_hsa000510.27164920
90Glioma_Homo sapiens_hsa052140.26147926
91N-Glycan biosynthesis_Homo sapiens_hsa005100.25396446
92Viral myocarditis_Homo sapiens_hsa054160.25130882
93Prion diseases_Homo sapiens_hsa050200.23071266
94Fatty acid metabolism_Homo sapiens_hsa012120.22386826
95Galactose metabolism_Homo sapiens_hsa000520.21442192
96Taste transduction_Homo sapiens_hsa047420.21357075
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20350338
98Calcium signaling pathway_Homo sapiens_hsa040200.19810719
99Peroxisome_Homo sapiens_hsa041460.19796506
100MicroRNAs in cancer_Homo sapiens_hsa052060.19209639

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