CYP4F23P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cell proliferation involved in kidney development (GO:1901722)5.27963223
2opsonization (GO:0008228)5.18890064
3endothelial cell chemotaxis (GO:0035767)5.00954968
4intestinal epithelial cell development (GO:0060576)4.81837870
5calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.72417956
6ear development (GO:0043583)4.65790786
7desmosome organization (GO:0002934)4.64855521
8COPI coating of Golgi vesicle (GO:0048205)4.62124420
9Golgi transport vesicle coating (GO:0048200)4.62124420
10proline biosynthetic process (GO:0006561)4.49136075
11mammary gland epithelial cell differentiation (GO:0060644)4.22892943
12epithelial cell maturation (GO:0002070)3.99647969
13uterus development (GO:0060065)3.91056623
14negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.84016654
15proline metabolic process (GO:0006560)3.83563925
16phosphate ion homeostasis (GO:0055062)3.82395930
17trivalent inorganic anion homeostasis (GO:0072506)3.82395930
18positive regulation of cellular amine metabolic process (GO:0033240)3.80517962
19positive regulation of keratinocyte differentiation (GO:0045618)3.79768747
20branching involved in mammary gland duct morphogenesis (GO:0060444)3.68415648
21cellular zinc ion homeostasis (GO:0006882)3.65062784
22negative regulation of cell size (GO:0045792)3.63060539
23regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.59137729
24prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.58637013
25regulation of cholesterol biosynthetic process (GO:0045540)3.57228379
26glutathione biosynthetic process (GO:0006750)3.54101846
27biotin metabolic process (GO:0006768)3.46976287
28primary alcohol catabolic process (GO:0034310)3.46134684
29positive regulation of glomerulus development (GO:0090193)3.44989259
30negative regulation of transcription by competitive promoter binding (GO:0010944)3.38677853
31cardiac right ventricle morphogenesis (GO:0003215)3.38124153
32norepinephrine metabolic process (GO:0042415)3.36686063
33face development (GO:0060324)3.33545745
34lung secretory cell differentiation (GO:0061140)3.33274057
35pantothenate metabolic process (GO:0015939)3.33205041
36maternal placenta development (GO:0001893)3.30685415
37L-phenylalanine metabolic process (GO:0006558)3.28758469
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.28758469
39endocrine hormone secretion (GO:0060986)3.24237722
40response to food (GO:0032094)3.24035679
41peptidyl-tyrosine autophosphorylation (GO:0038083)3.23751271
42regulation of water loss via skin (GO:0033561)3.20733853
43purine nucleotide transport (GO:0015865)3.18286933
44nonribosomal peptide biosynthetic process (GO:0019184)3.17651444
45regulation of establishment or maintenance of cell polarity (GO:0032878)3.17565042
46negative regulation of kidney development (GO:0090185)3.13360093
47keratinocyte development (GO:0003334)3.07461885
48mRNA cleavage (GO:0006379)3.04556920
49semaphorin-plexin signaling pathway (GO:0071526)3.00484084
50positive regulation of hormone metabolic process (GO:0032352)3.00382078
51cell aggregation (GO:0098743)2.99957426
52cartilage condensation (GO:0001502)2.99957426
53regulation of autophagic vacuole assembly (GO:2000785)2.98801784
54regulation of transforming growth factor beta1 production (GO:0032908)2.98224113
55xenobiotic catabolic process (GO:0042178)2.96413348
56COPII vesicle coating (GO:0048208)2.95363066
57facial nerve structural organization (GO:0021612)2.94455173
58diol metabolic process (GO:0034311)2.94065378
59regulation of interleukin-13 production (GO:0032656)2.93674401
60white fat cell differentiation (GO:0050872)2.93281331
61insulin-like growth factor receptor signaling pathway (GO:0048009)2.91412627
62positive regulation of epidermal cell differentiation (GO:0045606)2.90233061
63regulation of apoptotic cell clearance (GO:2000425)2.89208032
64lung epithelial cell differentiation (GO:0060487)2.85968680
65intracellular estrogen receptor signaling pathway (GO:0030520)2.85415810
66lung epithelium development (GO:0060428)2.85104372
67vagina development (GO:0060068)2.84848568
68maintenance of gastrointestinal epithelium (GO:0030277)2.84033427
69bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83831880
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.82657828
71multicellular organismal water homeostasis (GO:0050891)2.82224009
72exocrine pancreas development (GO:0031017)2.81592139
73lung cell differentiation (GO:0060479)2.79533335
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.78280142
75epithelial cell-cell adhesion (GO:0090136)2.75079797
76GDP-mannose metabolic process (GO:0019673)2.74158216
77cellular anion homeostasis (GO:0030002)2.73264392
78mammary gland alveolus development (GO:0060749)2.71620531
79regulation of interleukin-8 secretion (GO:2000482)2.71089784
80positive regulation of histone deacetylation (GO:0031065)2.70191318
81branching involved in prostate gland morphogenesis (GO:0060442)2.67948255
82regulation of hydrogen peroxide metabolic process (GO:0010310)2.67745055
83response to lead ion (GO:0010288)2.67055319
84negative regulation of cell fate commitment (GO:0010454)2.65991721
85ectoderm development (GO:0007398)2.65896540
86positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.65850099
87apical protein localization (GO:0045176)2.65232888
88nephron tubule formation (GO:0072079)2.61211268
89interferon-gamma secretion (GO:0072643)2.61183962
90dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.60575411
91zinc ion transmembrane transport (GO:0071577)2.59952983
92regulation of cholesterol metabolic process (GO:0090181)2.58422689
93regulation of fatty acid beta-oxidation (GO:0031998)2.57637094
94regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.57233338
95regulation of Cdc42 GTPase activity (GO:0043088)2.56992989
96glutathione derivative metabolic process (GO:1901685)2.55680747
97glutathione derivative biosynthetic process (GO:1901687)2.55680747
98dicarboxylic acid biosynthetic process (GO:0043650)2.54648984
99short-chain fatty acid metabolic process (GO:0046459)2.54351389
100ethanol metabolic process (GO:0006067)2.54144927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human6.83730547
2ESR2_21235772_ChIP-Seq_MCF-7_Human5.45948603
3ESR1_21235772_ChIP-Seq_MCF-7_Human5.05812099
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.52158427
5TFAP2C_20629094_ChIP-Seq_MCF-7_Human3.59291354
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.51409772
7RACK7_27058665_Chip-Seq_MCF-7_Human3.33444774
8ESR1_15608294_ChIP-ChIP_MCF-7_Human3.22552649
9RUNX1_27514584_Chip-Seq_MCF-7_Human3.06993144
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.63490714
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.47834724
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.43509302
13AHR_22903824_ChIP-Seq_MCF-7_Human2.35180093
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.26223430
15ZNF263_19887448_ChIP-Seq_K562_Human2.24635208
16GATA3_24758297_ChIP-Seq_MCF-7_Human2.20701362
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12740666
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11557335
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05521142
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02785358
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.98786019
22LXR_22292898_ChIP-Seq_THP-1_Human1.95270955
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94639189
24ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.92822143
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.80801117
26GATA6_25053715_ChIP-Seq_YYC3_Human1.79913393
27ELF5_23300383_ChIP-Seq_T47D_Human1.78662355
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77494831
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.71775638
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71510889
31CREB1_26743006_Chip-Seq_LNCaP_Human1.70276204
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.67768900
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65424749
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63129081
35SMC4_20622854_ChIP-Seq_HELA_Human1.60429886
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59539500
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.57617840
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.56007994
39CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.55237068
40P68_20966046_ChIP-Seq_HELA_Human1.51108843
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.49765616
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46967470
43SOX2_20726797_ChIP-Seq_SW620_Human1.46295401
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.41861827
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.41735945
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39638196
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33015090
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.30452367
49KDM5A_27292631_Chip-Seq_BREAST_Human1.30446367
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28015598
51CHD1_26751641_Chip-Seq_LNCaP_Human1.25508746
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23985751
53ATF3_27146783_Chip-Seq_COLON_Human1.22673166
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21340007
55CTCF_27219007_Chip-Seq_Bcells_Human1.21287042
56SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20125811
57KDM2B_26808549_Chip-Seq_K562_Human1.18665475
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.17308808
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15697477
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14524344
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13387801
62TCF7_22412390_ChIP-Seq_EML_Mouse1.13277385
63KDM2B_26808549_Chip-Seq_DND41_Human1.11845374
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11555675
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.07838153
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07491743
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06047516
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03921652
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03547367
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03498761
71KLF5_25053715_ChIP-Seq_YYC3_Human1.03315386
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02518981
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01919086
74ERA_21632823_ChIP-Seq_H3396_Human1.01210557
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01104115
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00546565
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.00538455
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00185536
79TP63_22573176_ChIP-Seq_HFKS_Human0.96992353
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96183659
81FOXA1_25552417_ChIP-Seq_VCAP_Human0.92644062
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91723207
83PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91515078
84SA1_27219007_Chip-Seq_ERYTHROID_Human0.91380604
85RARB_24833708_ChIP-Seq_LIVER_Mouse0.90584662
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90474226
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90296323
88BCOR_27268052_Chip-Seq_Bcells_Human0.89399609
89GATA4_25053715_ChIP-Seq_YYC3_Human0.88999227
90PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86356155
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86089344
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85329196
93SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84830242
94E2F1_20622854_ChIP-Seq_HELA_Human0.84537338
95CTCF_21964334_Chip-Seq_Bcells_Human0.83720251
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83482026
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83303086
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83301007
99AR_21909140_ChIP-Seq_LNCAP_Human0.82778697
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.81380563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.15815430
2MP0004264_abnormal_extraembryonic_tissu3.99205726
3MP0004381_abnormal_hair_follicle3.65084318
4MP0009780_abnormal_chondrocyte_physiolo3.25815368
5MP0005646_abnormal_pituitary_gland3.23479871
6MP0003183_abnormal_peptide_metabolism2.85745532
7MP0002822_catalepsy2.85686527
8MP0010386_abnormal_urinary_bladder2.83517761
9MP0001873_stomach_inflammation2.46843476
10MP0002282_abnormal_trachea_morphology2.45125764
11MP0002277_abnormal_respiratory_mucosa2.39929141
12MP0005083_abnormal_biliary_tract2.31651255
13MP0002796_impaired_skin_barrier2.27201351
14MP0002098_abnormal_vibrissa_morphology2.18595062
15MP0002132_abnormal_respiratory_system2.00895733
16MP0000538_abnormal_urinary_bladder2.00288353
17MP0002249_abnormal_larynx_morphology1.97221460
18MP0001348_abnormal_lacrimal_gland1.92294872
19MP0005645_abnormal_hypothalamus_physiol1.90658291
20MP0000678_abnormal_parathyroid_gland1.89671170
21MP0008995_early_reproductive_senescence1.88736557
22MP0002089_abnormal_postnatal_growth/wei1.84721887
23MP0003279_aneurysm1.82112964
24MP0000627_abnormal_mammary_gland1.78139435
25MP0003195_calcinosis1.73689078
26MP0000613_abnormal_salivary_gland1.71258462
27MP0002009_preneoplasia1.70148081
28MP0001666_abnormal_nutrient_absorption1.66624676
29MP0001664_abnormal_digestion1.62285789
30MP0005503_abnormal_tendon_morphology1.61826140
31MP0008872_abnormal_physiological_respon1.60528460
32MP0002166_altered_tumor_susceptibility1.56496509
33MP0001881_abnormal_mammary_gland1.55739977
34MP0005076_abnormal_cell_differentiation1.50414405
35MP0008961_abnormal_basal_metabolism1.48854307
36MP0004782_abnormal_surfactant_physiolog1.48444557
37MP0000427_abnormal_hair_cycle1.46028575
38MP0003938_abnormal_ear_development1.45947573
39MP0000462_abnormal_digestive_system1.44172297
40MP0002108_abnormal_muscle_morphology1.44069378
41MP0005220_abnormal_exocrine_pancreas1.35823061
42MP0005670_abnormal_white_adipose1.34675418
43MP0003638_abnormal_response/metabolism_1.34166893
44MP0010678_abnormal_skin_adnexa1.31918904
45MP0010030_abnormal_orbit_morphology1.31394809
46MP0003942_abnormal_urinary_system1.29418795
47MP0003191_abnormal_cellular_cholesterol1.29205661
48MP0003936_abnormal_reproductive_system1.29020801
49MP0000566_synostosis1.24651061
50MP0008875_abnormal_xenobiotic_pharmacok1.24349312
51MP0003123_paternal_imprinting1.22371210
52MP0005377_hearing/vestibular/ear_phenot1.21699518
53MP0003878_abnormal_ear_physiology1.21699518
54MP0000377_abnormal_hair_follicle1.21643984
55MP0001919_abnormal_reproductive_system1.20899366
56MP0008004_abnormal_stomach_pH1.18415185
57MP0000383_abnormal_hair_follicle1.16992561
58MP0000534_abnormal_ureter_morphology1.15603861
59MP0005365_abnormal_bile_salt1.12767521
60MP0000767_abnormal_smooth_muscle1.09867494
61MP0000537_abnormal_urethra_morphology1.06759299
62MP0005410_abnormal_fertilization1.04697282
63MP0001849_ear_inflammation1.03351239
64MP0001756_abnormal_urination1.03266167
65MP0003941_abnormal_skin_development1.02930144
66MP0002254_reproductive_system_inflammat1.02190743
67MP0003315_abnormal_perineum_morphology1.00482555
68MP0001346_abnormal_lacrimal_gland1.00480819
69MP0000470_abnormal_stomach_morphology0.99316402
70MP0002160_abnormal_reproductive_system0.98712114
71MP0009840_abnormal_foam_cell0.98207538
72MP0002751_abnormal_autonomic_nervous0.95413883
73MP0005058_abnormal_lysosome_morphology0.94199723
74MP0004043_abnormal_pH_regulation0.94053213
75MP0005501_abnormal_skin_physiology0.91733793
76MP0005248_abnormal_Harderian_gland0.90146304
77MP0000681_abnormal_thyroid_gland0.89837514
78MP0001765_abnormal_ion_homeostasis0.88473027
79MP0001727_abnormal_embryo_implantation0.87458993
80MP0001270_distended_abdomen0.85437264
81MP0005647_abnormal_sex_gland0.85379651
82MP0000467_abnormal_esophagus_morphology0.84072401
83MP0003705_abnormal_hypodermis_morpholog0.83759167
84MP0003045_fibrosis0.81344351
85MP0003172_abnormal_lysosome_physiology0.79870955
86MP0003300_gastrointestinal_ulcer0.77566847
87MP0008260_abnormal_autophagy0.77490831
88MP0000477_abnormal_intestine_morphology0.77399822
89MP0005085_abnormal_gallbladder_physiolo0.75470370
90MP0000371_diluted_coat_color0.74552961
91MP0001216_abnormal_epidermal_layer0.74357345
92MP0002168_other_aberrant_phenotype0.73572781
93MP0004858_abnormal_nervous_system0.72634236
94MP0002932_abnormal_joint_morphology0.71741809
95MP0001485_abnormal_pinna_reflex0.70984713
96MP0002006_tumorigenesis0.70744412
97MP0003866_abnormal_defecation0.69994544
98MP0005409_darkened_coat_color0.68490665
99MP0009672_abnormal_birth_weight0.67592531
100MP0000163_abnormal_cartilage_morphology0.67027017

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.15960348
2Sparse lateral eyebrow (HP:0005338)4.88739810
3Spontaneous abortion (HP:0005268)4.05810180
4J-shaped sella turcica (HP:0002680)4.01474143
5Lip pit (HP:0100267)3.66229933
6Pulmonary artery stenosis (HP:0004415)3.50127652
7Septate vagina (HP:0001153)3.41230806
8Abnormal cartilage morphology (HP:0002763)3.40823087
9Chronic sinusitis (HP:0011109)3.38537461
10Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)3.28595242
11Macroorchidism (HP:0000053)3.21190597
12Right ventricular cardiomyopathy (HP:0011663)3.14028876
13Deep philtrum (HP:0002002)3.08617075
14Infantile muscular hypotonia (HP:0008947)3.08243084
15Abnormality of the astrocytes (HP:0100707)3.04079725
16Astrocytoma (HP:0009592)3.04079725
17Aplasia of the musculature (HP:0100854)2.98612317
18Nasal speech (HP:0001611)2.97840390
19Ependymoma (HP:0002888)2.96810856
20Testicular atrophy (HP:0000029)2.92157501
21Ileus (HP:0002595)2.90005469
22Tracheal stenosis (HP:0002777)2.86844525
23Hypoparathyroidism (HP:0000829)2.76844525
24Flat capital femoral epiphysis (HP:0003370)2.75498233
25Lymphangioma (HP:0100764)2.75130119
26Asymmetry of the thorax (HP:0001555)2.73591521
27Tented upper lip vermilion (HP:0010804)2.72218605
28Abnormality of the epiphyses of the hand (HP:0005924)2.69257955
29Hamartoma of the eye (HP:0010568)2.68836388
30Flat acetabular roof (HP:0003180)2.68246198
31Large eyes (HP:0001090)2.67376945
32Diaphragmatic weakness (HP:0009113)2.65073104
33Deep venous thrombosis (HP:0002625)2.64792939
34Generalized amyotrophy (HP:0003700)2.61904547
35Breast carcinoma (HP:0003002)2.57504278
36Thin bony cortex (HP:0002753)2.56462156
37Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.50393670
38Epiphyseal stippling (HP:0010655)2.41447682
39Hyperkalemia (HP:0002153)2.40899129
40Abnormality of the nasal septum (HP:0000419)2.40028574
41Spinal cord compression (HP:0002176)2.38469281
42Testicular neoplasm (HP:0010788)2.37330090
43High pitched voice (HP:0001620)2.30687305
44Amelogenesis imperfecta (HP:0000705)2.28521598
45Glomerulonephritis (HP:0000099)2.28241294
46Broad nasal tip (HP:0000455)2.28071415
47Abnormality of the proximal phalanges of the hand (HP:0009834)2.27017530
48Pili torti (HP:0003777)2.25712158
49Congenital ichthyosiform erythroderma (HP:0007431)2.25459779
50Abnormality of chloride homeostasis (HP:0011422)2.24652476
51Abnormality of nail color (HP:0100643)2.23249206
52Curly hair (HP:0002212)2.22638182
53Germ cell neoplasia (HP:0100728)2.21675170
54Glioma (HP:0009733)2.21207510
55Male infertility (HP:0003251)2.20151657
56Easy fatigability (HP:0003388)2.17991938
57Ankyloglossia (HP:0010296)2.15400283
58Hyperacusis (HP:0010780)2.15225358
59Abnormality of the parathyroid morphology (HP:0011766)2.13375643
60Abnormality of the femoral head (HP:0003368)2.10690707
61Recurrent bronchitis (HP:0002837)2.09535955
62Exostoses (HP:0100777)2.03921810
63Short hallux (HP:0010109)2.02102904
64Papilledema (HP:0001085)2.01225666
65Cervical subluxation (HP:0003308)2.00801559
66Azoospermia (HP:0000027)1.99969286
67Flattened epiphyses (HP:0003071)1.99321189
68Congenital glaucoma (HP:0001087)1.99243198
69Severe Myopia (HP:0011003)1.98492908
70Hydroxyprolinuria (HP:0003080)1.97845886
71Abnormality of proline metabolism (HP:0010907)1.97845886
72Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.95384549
73High anterior hairline (HP:0009890)1.91949093
74Hypokinesia (HP:0002375)1.90422139
75Enlarged penis (HP:0000040)1.87362758
76Abnormality of the epiphysis of the femoral head (HP:0010574)1.86576001
77Bulbar palsy (HP:0001283)1.85743723
78Hypoplasia of the odontoid process (HP:0003311)1.85092196
79Increased neuronal autofluorescent lipopigment (HP:0002074)1.85081847
80Pseudobulbar signs (HP:0002200)1.80815008
81Nuclear cataract (HP:0100018)1.80472518
82Abnormal epiphyseal ossification (HP:0010656)1.80332041
83Abnormality of the dental root (HP:0006486)1.79673398
84Taurodontia (HP:0000679)1.79673398
85Abnormality of permanent molar morphology (HP:0011071)1.79673398
86Bronchitis (HP:0012387)1.79319249
87Cerebral aneurysm (HP:0004944)1.78997622
88Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78919063
89Axonal loss (HP:0003447)1.78725526
90Abnormality of the distal phalanges of the toes (HP:0010182)1.78378424
91Abnormality of carpal bone ossification (HP:0006257)1.78195950
92Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76959637
93Blue sclerae (HP:0000592)1.76719543
94Broad face (HP:0000283)1.75999454
95Hypophosphatemia (HP:0002148)1.75685270
96Short thumb (HP:0009778)1.75363172
97Abnormality of femoral epiphyses (HP:0006499)1.74805016
98Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.74805016
99Abnormality of dentin (HP:0010299)1.72415714
100Vascular calcification (HP:0004934)1.72352174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.83260609
2LMTK24.68796884
3SIK14.25027733
4PKN24.01643398
5EPHA23.75753198
6MAPKAPK33.50406619
7FER3.04674305
8PRKCI2.52119357
9MUSK2.38137891
10MST42.15962573
11INSRR2.10064308
12EEF2K2.08616888
13PTK22.00128302
14STK241.95795393
15TNK21.93170144
16RPS6KB21.86344255
17NME21.84275778
18ERN11.73132598
19SMG11.65409975
20MST1R1.63953880
21ILK1.58133172
22NME11.53536029
23LRRK21.46769915
24PAK31.44888425
25CHUK1.44076348
26PRKG21.40493171
27ICK1.31325297
28TAOK11.30547977
29MAPK151.29641536
30TESK11.19957627
31RPS6KA21.19425221
32NEK61.16808960
33FGFR41.12010677
34VRK21.09310279
35PIK3CA1.08740325
36MYLK1.06020147
37RIPK11.05562702
38FGFR11.03740455
39GRK61.02957806
40CDK71.02418944
41STK390.99565042
42STK38L0.97222362
43MAP2K60.96988694
44PAK40.92952390
45MAP2K10.92118995
46MTOR0.88110871
47PTK60.81526251
48MAP2K20.79328516
49EIF2AK10.76247953
50ERBB20.73672194
51TESK20.73051260
52MARK20.69980173
53MAP3K120.69342813
54RPS6KL10.65134969
55RPS6KC10.65134969
56SCYL20.64156682
57RPS6KB10.62519189
58AKT30.62385713
59PRKD10.62160724
60TRIM280.62106285
61MAP3K130.61332773
62PRKD20.60367173
63CDK120.60155667
64LATS20.59621998
65FGFR20.58230062
66MATK0.57508814
67MET0.54773437
68RPS6KA60.54460787
69ROCK10.53093698
70HIPK20.50588953
71MAPKAPK20.48110660
72STK380.48107736
73RET0.46055805
74IRAK30.45234759
75EIF2AK30.44978616
76SIK30.44780706
77PBK0.42880825
78DAPK10.42156609
79AKT20.39382916
80IKBKE0.39022488
81LATS10.38482146
82MELK0.36062009
83CAMK1D0.32135049
84PRKAA10.30762662
85MAPKAPK50.30163592
86PAK10.30109850
87CDK30.29327620
88RPS6KA10.27902043
89GSK3A0.26707761
90IKBKB0.26308660
91TLK10.22733072
92TSSK60.20520209
93WNK40.19530712
94CSNK1E0.17974280
95CAMK1G0.17355856
96PDPK10.17118593
97MAP3K70.16687773
98MAPK80.16255684
99TBK10.15874667
100PIM20.15747883

Predicted pathways (KEGG)

RankGene SetZ-score
1ABC transporters_Homo sapiens_hsa020102.52486018
2Glutathione metabolism_Homo sapiens_hsa004802.42223625
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11776498
4Tyrosine metabolism_Homo sapiens_hsa003502.07343563
5Tight junction_Homo sapiens_hsa045301.99900235
6Phenylalanine metabolism_Homo sapiens_hsa003601.94757431
7Fatty acid biosynthesis_Homo sapiens_hsa000611.94579670
8Fructose and mannose metabolism_Homo sapiens_hsa000511.92902496
9Sphingolipid metabolism_Homo sapiens_hsa006001.84797787
10Proteasome_Homo sapiens_hsa030501.79507066
11Vibrio cholerae infection_Homo sapiens_hsa051101.79226082
12Chemical carcinogenesis_Homo sapiens_hsa052041.77393261
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.71617528
14Hepatitis C_Homo sapiens_hsa051601.69932344
15Endometrial cancer_Homo sapiens_hsa052131.68277104
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67104075
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65751524
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.62697728
19Sulfur relay system_Homo sapiens_hsa041221.57540997
20Sulfur metabolism_Homo sapiens_hsa009201.54688740
21N-Glycan biosynthesis_Homo sapiens_hsa005101.53878399
22Fatty acid elongation_Homo sapiens_hsa000621.53323185
23Vitamin B6 metabolism_Homo sapiens_hsa007501.51417144
24AMPK signaling pathway_Homo sapiens_hsa041521.47387987
25Other glycan degradation_Homo sapiens_hsa005111.46965704
26Histidine metabolism_Homo sapiens_hsa003401.46732749
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.45013043
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43100030
29Estrogen signaling pathway_Homo sapiens_hsa049151.40692099
30Fatty acid metabolism_Homo sapiens_hsa012121.38916691
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.35084711
32Notch signaling pathway_Homo sapiens_hsa043301.33540379
33Bile secretion_Homo sapiens_hsa049761.32659191
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31152870
35mTOR signaling pathway_Homo sapiens_hsa041501.20691228
36Prostate cancer_Homo sapiens_hsa052151.20087349
37Ovarian steroidogenesis_Homo sapiens_hsa049131.14673955
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13323667
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11105365
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.09745937
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06634124
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02613561
43Insulin signaling pathway_Homo sapiens_hsa049101.01947683
44Butanoate metabolism_Homo sapiens_hsa006501.01189630
45Pancreatic secretion_Homo sapiens_hsa049721.01156417
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99736852
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98649084
48Thyroid hormone synthesis_Homo sapiens_hsa049180.98511227
49Choline metabolism in cancer_Homo sapiens_hsa052310.97683797
50Prolactin signaling pathway_Homo sapiens_hsa049170.96351006
51Lysine degradation_Homo sapiens_hsa003100.94439560
52Peroxisome_Homo sapiens_hsa041460.92455347
53Acute myeloid leukemia_Homo sapiens_hsa052210.92302571
54Thyroid cancer_Homo sapiens_hsa052160.88140697
55Steroid biosynthesis_Homo sapiens_hsa001000.87743932
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86750613
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86144612
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85310905
59Caffeine metabolism_Homo sapiens_hsa002320.81556843
60beta-Alanine metabolism_Homo sapiens_hsa004100.80939472
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80252568
62Pentose phosphate pathway_Homo sapiens_hsa000300.79636035
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78345751
64Circadian rhythm_Homo sapiens_hsa047100.77826871
65Arachidonic acid metabolism_Homo sapiens_hsa005900.75339728
66Vitamin digestion and absorption_Homo sapiens_hsa049770.73542336
67Arginine and proline metabolism_Homo sapiens_hsa003300.73040686
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72836430
69Insulin resistance_Homo sapiens_hsa049310.70959667
70Proteoglycans in cancer_Homo sapiens_hsa052050.69565519
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69323784
72Non-small cell lung cancer_Homo sapiens_hsa052230.69305621
73VEGF signaling pathway_Homo sapiens_hsa043700.68375678
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.68038408
75ECM-receptor interaction_Homo sapiens_hsa045120.62877172
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.60812917
77Taste transduction_Homo sapiens_hsa047420.60736638
78ErbB signaling pathway_Homo sapiens_hsa040120.59263465
79Bladder cancer_Homo sapiens_hsa052190.58902012
80Lysosome_Homo sapiens_hsa041420.58488591
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.56815755
82Nitrogen metabolism_Homo sapiens_hsa009100.56100389
83Fatty acid degradation_Homo sapiens_hsa000710.52604273
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52406643
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51920060
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51590464
87B cell receptor signaling pathway_Homo sapiens_hsa046620.50635467
88Focal adhesion_Homo sapiens_hsa045100.50617778
89Chronic myeloid leukemia_Homo sapiens_hsa052200.47943791
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45683377
91Dorso-ventral axis formation_Homo sapiens_hsa043200.44889204
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44614350
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.44299099
94Endocytosis_Homo sapiens_hsa041440.43124764
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42682635
96Complement and coagulation cascades_Homo sapiens_hsa046100.41838914
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40597842
98Mineral absorption_Homo sapiens_hsa049780.39968175
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37132210
100Gastric acid secretion_Homo sapiens_hsa049710.34707135

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