ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	auditory receptor cell differentiation (GO:0042491)	6.87601331
2	glycerophospholipid catabolic process (GO:0046475)	4.68041592
3	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.51152105
4	cellular response to leptin stimulus (GO:0044320)	4.47026961
5	cellular ketone body metabolic process (GO:0046950)	4.38940338
6	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	4.37316851
7	L-alpha-amino acid transmembrane transport (GO:1902475)	4.28208350
8	cerebellar Purkinje cell layer development (GO:0021680)	4.25474809
9	peptide hormone processing (GO:0016486)	4.25171307
10	toxin metabolic process (GO:0009404)	4.22469981
11	vascular smooth muscle contraction (GO:0014829)	4.07068929
12	artery smooth muscle contraction (GO:0014824)	4.02694880
13	insulin secretion (GO:0030073)	3.94342359
14	response to dietary excess (GO:0002021)	3.87431962
15	ketone body metabolic process (GO:1902224)	3.85107647
16	cellular zinc ion homeostasis (GO:0006882)	3.82877137
17	epithelial cell fate commitment (GO:0072148)	3.82732477
18	response to leptin (GO:0044321)	3.79116915
19	hair cell differentiation (GO:0035315)	3.74627533
20	astrocyte differentiation (GO:0048708)	3.70516887
21	macroautophagy (GO:0016236)	3.62740931
22	zinc ion homeostasis (GO:0055069)	3.61225235
23	negative regulation of execution phase of apoptosis (GO:1900118)	3.52785847
24	inner ear receptor cell differentiation (GO:0060113)	3.51291408
25	regulation of extracellular matrix disassembly (GO:0010715)	3.49631465
26	tonic smooth muscle contraction (GO:0014820)	3.43254418
27	nodal signaling pathway (GO:0038092)	3.42101746
28	nonmotile primary cilium assembly (GO:0035058)	3.32834712
29	endocrine pancreas development (GO:0031018)	3.32050170
30	negative regulation of cAMP-mediated signaling (GO:0043951)	3.28357706
31	mechanoreceptor differentiation (GO:0042490)	3.23101619
32	positive regulation of insulin secretion (GO:0032024)	3.18554141
33	positive regulation of gluconeogenesis (GO:0045722)	3.15691134
34	regulation of cilium movement (GO:0003352)	3.09265682
35	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.03564720
36	beta-amyloid metabolic process (GO:0050435)	2.99777007
37	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.97964819
38	vitamin D metabolic process (GO:0042359)	2.97741955
39	retinal rod cell development (GO:0046548)	2.97536045
40	cardiac left ventricle morphogenesis (GO:0003214)	2.96794572
41	toxin transport (GO:1901998)	2.90842644
42	amyloid precursor protein catabolic process (GO:0042987)	2.87950531
43	neuromuscular process controlling posture (GO:0050884)	2.86616024
44	brain morphogenesis (GO:0048854)	2.85006575
45	detection of calcium ion (GO:0005513)	2.84240056
46	limb development (GO:0060173)	2.83604530
47	appendage development (GO:0048736)	2.83604530
48	photoreceptor cell maintenance (GO:0045494)	2.81356801
49	reverse cholesterol transport (GO:0043691)	2.80378374
50	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.77198737
51	zinc ion transmembrane transport (GO:0071577)	2.76955465
52	phosphatidylcholine biosynthetic process (GO:0006656)	2.76550802
53	regulation of autophagic vacuole assembly (GO:2000785)	2.76522996
54	prenylation (GO:0097354)	2.68602062
55	protein prenylation (GO:0018342)	2.68602062
56	positive regulation of neurotransmitter transport (GO:0051590)	2.68557190
57	carnitine transport (GO:0015879)	2.67193462
58	amino-acid betaine transport (GO:0015838)	2.67193462
59	negative regulation of glycoprotein biosynthetic process (GO:0010561)	2.65403373
60	peptide hormone secretion (GO:0030072)	2.63625120
61	regulation of protein kinase C signaling (GO:0090036)	2.62039896
62	regulation of protein glycosylation (GO:0060049)	2.61662084
63	chondroitin sulfate catabolic process (GO:0030207)	2.59744877
64	peptide secretion (GO:0002790)	2.58414644
65	negative regulation of appetite (GO:0032099)	2.56400104
66	negative regulation of response to food (GO:0032096)	2.56400104
67	retinol metabolic process (GO:0042572)	2.55472010
68	regulation of respiratory system process (GO:0044065)	2.55367703
69	single strand break repair (GO:0000012)	2.54846269
70	positive regulation of peptide hormone secretion (GO:0090277)	2.54788179
71	neuron fate specification (GO:0048665)	2.54330514
72	regulation of neurotransmitter uptake (GO:0051580)	2.52414390
73	photoreceptor cell differentiation (GO:0046530)	2.52119847
74	eye photoreceptor cell differentiation (GO:0001754)	2.52119847
75	regulation of vacuole organization (GO:0044088)	2.50574871
76	response to auditory stimulus (GO:0010996)	2.50240281
77	potassium ion export (GO:0071435)	2.50062626
78	glucosamine-containing compound catabolic process (GO:1901072)	2.49984142
79	synaptic vesicle maturation (GO:0016188)	2.49875598
80	potassium ion homeostasis (GO:0055075)	2.49768716
81	vasodilation (GO:0042311)	2.49415380
82	branched-chain amino acid catabolic process (GO:0009083)	2.47597677
83	positive regulation of peptide secretion (GO:0002793)	2.47539980
84	ethanol oxidation (GO:0006069)	2.46847372
85	peptide metabolic process (GO:0006518)	2.46154314
86	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.44885187
87	L-phenylalanine catabolic process (GO:0006559)	2.44885187
88	heme transport (GO:0015886)	2.42984119
89	mitochondrial calcium ion homeostasis (GO:0051560)	2.42836964
90	renal absorption (GO:0070293)	2.41682453
91	glandular epithelial cell differentiation (GO:0002067)	2.41269898
92	neuron cell-cell adhesion (GO:0007158)	2.41200163
93	innervation (GO:0060384)	2.40749793
94	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.40224626
95	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.39062392
96	regulation of execution phase of apoptosis (GO:1900117)	2.38820237
97	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.37941474
98	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.37641800
99	preassembly of GPI anchor in ER membrane (GO:0016254)	2.36776334
100	C-terminal protein lipidation (GO:0006501)	2.36619099

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.40661249
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.62860891
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.49693105
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.29620186
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.85241536
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.25534146
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.03528787
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92268955
9	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.88814188
10	HTT_18923047_ChIP-ChIP_STHdh_Human	1.80151352
11	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.77366125
12	TAF15_26573619_Chip-Seq_HEK293_Human	1.74527006
13	ZNF274_21170338_ChIP-Seq_K562_Hela	1.71032763
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64690865
15	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.64511581
16	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61666394
17	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60125554
18	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.51159033
19	REST_21632747_ChIP-Seq_MESCs_Mouse	1.49249206
20	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.48901630
21	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47995148
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47869439
23	P300_19829295_ChIP-Seq_ESCs_Human	1.45457448
24	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44866644
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44413204
26	STAT3_23295773_ChIP-Seq_U87_Human	1.44266142
27	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.43408985
28	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.42644116
29	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.42107371
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41253391
31	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.37668132
32	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.36621432
33	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.34157239
34	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32746534
35	FUS_26573619_Chip-Seq_HEK293_Human	1.32278570
36	VDR_22108803_ChIP-Seq_LS180_Human	1.32123342
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.31400079
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.29938452
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29638707
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.29638707
41	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.27853940
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27451817
43	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22893045
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21183671
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20952207
46	TCF4_23295773_ChIP-Seq_U87_Human	1.20526972
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.20371786
48	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.19549697
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18715596
50	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.17735700
51	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.17663191
52	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.13786939
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13328255
54	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.13090142
55	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.13030422
56	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.12056086
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.12014956
58	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11758511
59	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.11095993
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.10833205
61	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10599359
62	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.10525152
63	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10229646
64	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.09223467
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08638343
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08354314
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07520830
68	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05975369
69	AR_25329375_ChIP-Seq_VCAP_Human	1.05332549
70	CDX2_22108803_ChIP-Seq_LS180_Human	1.05262308
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04875493
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04875493
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04858277
74	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.04838266
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.03990335
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02154551
77	STAT1_17558387_ChIP-Seq_HELA_Human	1.02013184
78	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01664336
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.01323238
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01122228
81	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.00986595
82	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.00802538
83	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.00635373
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00227720
85	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.00003789
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99772524
87	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.99707062
88	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99294585
89	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99148584
90	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.99070844
91	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.98654848
92	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.96142090
93	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.96142090
94	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96080631
95	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.95783963
96	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.94387170
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94310160
98	AR_20517297_ChIP-Seq_VCAP_Human	0.92976915
99	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.92811507
100	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.92255465

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009780_abnormal_chondrocyte_physiolo	5.74989901
2	MP0002837_dystrophic_cardiac_calcinosis	3.96467820
3	MP0005379_endocrine/exocrine_gland_phen	3.66816897
4	MP0002139_abnormal_hepatobiliary_system	3.64129169
5	MP0002909_abnormal_adrenal_gland	3.49422368
6	MP0005645_abnormal_hypothalamus_physiol	3.17582482
7	MP0000013_abnormal_adipose_tissue	3.16798273
8	MP0004019_abnormal_vitamin_homeostasis	3.06308388
9	MP0002254_reproductive_system_inflammat	2.86946696
10	MP0003879_abnormal_hair_cell	2.32506940
11	MP0003787_abnormal_imprinting	2.32221153
12	MP0002163_abnormal_gland_morphology	2.28515341
13	MP0003011_delayed_dark_adaptation	2.16024111
14	MP0001984_abnormal_olfaction	2.14803208
15	MP0004270_analgesia	2.02358540
16	MP0001944_abnormal_pancreas_morphology	2.00199167
17	MP0010329_abnormal_lipoprotein_level	1.91897381
18	MP0005174_abnormal_tail_pigmentation	1.82313089
19	MP0003136_yellow_coat_color	1.74089735
20	MP0005646_abnormal_pituitary_gland	1.70635166
21	MP0005167_abnormal_blood-brain_barrier	1.68284476
22	MP0002693_abnormal_pancreas_physiology	1.67308935
23	MP0001756_abnormal_urination	1.66481155
24	MP0005332_abnormal_amino_acid	1.66379970
25	MP0005551_abnormal_eye_electrophysiolog	1.65303844
26	MP0002876_abnormal_thyroid_physiology	1.61393957
27	MP0005636_abnormal_mineral_homeostasis	1.58930560
28	MP0003122_maternal_imprinting	1.56441859
29	MP0001986_abnormal_taste_sensitivity	1.55312211
30	MP0006072_abnormal_retinal_apoptosis	1.53009612
31	MP0002734_abnormal_mechanical_nocicepti	1.49890526
32	MP0003172_abnormal_lysosome_physiology	1.49720434
33	MP0009046_muscle_twitch	1.48923437
34	MP0002064_seizures	1.47368772
35	MP0002272_abnormal_nervous_system	1.47360132
36	MP0001485_abnormal_pinna_reflex	1.46262501
37	MP0003633_abnormal_nervous_system	1.43773077
38	MP0000631_abnormal_neuroendocrine_gland	1.42745717
39	MP0004885_abnormal_endolymph	1.42439829
40	MP0001765_abnormal_ion_homeostasis	1.37661431
41	MP0005248_abnormal_Harderian_gland	1.36485849
42	MP0001502_abnormal_circadian_rhythm	1.36423707
43	MP0000003_abnormal_adipose_tissue	1.34930937
44	MP0001970_abnormal_pain_threshold	1.33044900
45	MP0005058_abnormal_lysosome_morphology	1.32087985
46	MP0002638_abnormal_pupillary_reflex	1.30252658
47	MP0009745_abnormal_behavioral_response	1.30087523
48	MP0006054_spinal_hemorrhage	1.28073432
49	MP0005670_abnormal_white_adipose	1.27456477
50	MP0005253_abnormal_eye_physiology	1.27148006
51	MP0003690_abnormal_glial_cell	1.23327568
52	MP0000372_irregular_coat_pigmentation	1.21225280
53	MP0000639_abnormal_adrenal_gland	1.20635599
54	MP0003868_abnormal_feces_composition	1.19855721
55	MP0002078_abnormal_glucose_homeostasis	1.18619325
56	MP0002572_abnormal_emotion/affect_behav	1.18513321
57	MP0002090_abnormal_vision	1.17202059
58	MP0001486_abnormal_startle_reflex	1.16745928
59	MP0002733_abnormal_thermal_nociception	1.14688686
60	MP0003121_genomic_imprinting	1.10822954
61	MP0004133_heterotaxia	1.10175105
62	MP0002938_white_spotting	1.05960468
63	MP0009840_abnormal_foam_cell	1.05757679
64	MP0001968_abnormal_touch/_nociception	1.05249668
65	MP0003953_abnormal_hormone_level	1.03619369
66	MP0001664_abnormal_digestion	1.02804542
67	MP0005535_abnormal_body_temperature	1.02752409
68	MP0001529_abnormal_vocalization	0.99690355
69	MP0001501_abnormal_sleep_pattern	0.98929598
70	MP0005448_abnormal_energy_balance	0.97080413
71	MP0003634_abnormal_glial_cell	0.96555430
72	MP0002557_abnormal_social/conspecific_i	0.95711701
73	MP0002118_abnormal_lipid_homeostasis	0.95000566
74	MP0004142_abnormal_muscle_tone	0.94454826
75	MP0003631_nervous_system_phenotype	0.93216972
76	MP0005365_abnormal_bile_salt	0.91416211
77	MP0002138_abnormal_hepatobiliary_system	0.87196801
78	MP0008877_abnormal_DNA_methylation	0.85439745
79	MP0002653_abnormal_ependyma_morphology	0.85306695
80	MP0002063_abnormal_learning/memory/cond	0.84990186
81	MP0004085_abnormal_heartbeat	0.82961141
82	MP0002229_neurodegeneration	0.79183299
83	MP0001963_abnormal_hearing_physiology	0.76318909
84	MP0002127_abnormal_cardiovascular_syste	0.76187058
85	MP0005386_behavior/neurological_phenoty	0.75947103
86	MP0004924_abnormal_behavior	0.75947103
87	MP0003632_abnormal_nervous_system	0.74446426
88	MP0003635_abnormal_synaptic_transmissio	0.72937232
89	MP0003183_abnormal_peptide_metabolism	0.71397296
90	MP0005084_abnormal_gallbladder_morpholo	0.70727695
91	MP0004215_abnormal_myocardial_fiber	0.69545719
92	MP0001764_abnormal_homeostasis	0.69087098
93	MP0002295_abnormal_pulmonary_circulatio	0.68496516
94	MP0005220_abnormal_exocrine_pancreas	0.67813394
95	MP0000230_abnormal_systemic_arterial	0.67736267
96	MP0000920_abnormal_myelination	0.67032126
97	MP0002069_abnormal_eating/drinking_beha	0.65670112
98	MP0000026_abnormal_inner_ear	0.64954836
99	MP0001270_distended_abdomen	0.64867180
100	MP0004147_increased_porphyrin_level	0.64344821

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Polyphagia (HP:0002591)	4.10898506
2	Hyperglycemia (HP:0003074)	3.79286730
3	Hemiparesis (HP:0001269)	3.77506400
4	Congenital malformation of the right heart (HP:0011723)	3.62827234
5	Double outlet right ventricle (HP:0001719)	3.62827234
6	Congenital sensorineural hearing impairment (HP:0008527)	3.61805430
7	Ketoacidosis (HP:0001993)	3.53928437
8	Increased CSF protein (HP:0002922)	3.31492867
9	Hypoglycemic coma (HP:0001325)	3.30014161
10	Large for gestational age (HP:0001520)	3.20518987
11	Intestinal atresia (HP:0011100)	3.17341402
12	Medial flaring of the eyebrow (HP:0010747)	3.16187304
13	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.09334749
14	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.05527017
15	Abnormality of alanine metabolism (HP:0010916)	3.05527017
16	Hyperalaninemia (HP:0003348)	3.05527017
17	Proximal tubulopathy (HP:0000114)	2.98569633
18	Hypoglycemic seizures (HP:0002173)	2.78417072
19	Abnormality of polysaccharide metabolism (HP:0011012)	2.77513496
20	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.77513496
21	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.77513496
22	Abnormality of vitamin B metabolism (HP:0004340)	2.75422084
23	Mucopolysacchariduria (HP:0008155)	2.74780991
24	Urinary glycosaminoglycan excretion (HP:0003541)	2.74780991
25	Constricted visual fields (HP:0001133)	2.74718726
26	Late onset (HP:0003584)	2.74694749
27	Abnormal eating behavior (HP:0100738)	2.73168532
28	Hyperinsulinemic hypoglycemia (HP:0000825)	2.72949241
29	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.72868449
30	Joint hemorrhage (HP:0005261)	2.60986696
31	Ketosis (HP:0001946)	2.60972462
32	Progressive neurologic deterioration (HP:0002344)	2.52438042
33	Abnormality of vitamin metabolism (HP:0100508)	2.47478236
34	Agitation (HP:0000713)	2.46502771
35	Type II lissencephaly (HP:0007260)	2.44771012
36	Prolonged partial thromboplastin time (HP:0003645)	2.44660170
37	Intention tremor (HP:0002080)	2.43078024
38	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.42409630
39	3-Methylglutaconic aciduria (HP:0003535)	2.42063395
40	Hyperglycinemia (HP:0002154)	2.40821261
41	Cardiomegaly (HP:0001640)	2.38486379
42	Abnormality of binocular vision (HP:0011514)	2.33691449
43	Diplopia (HP:0000651)	2.33691449
44	Prominent supraorbital ridges (HP:0000336)	2.33353020
45	Fetal akinesia sequence (HP:0001989)	2.29755491
46	Abnormality of urine glucose concentration (HP:0011016)	2.27508062
47	Glycosuria (HP:0003076)	2.27508062
48	Hyperphosphatemia (HP:0002905)	2.23356770
49	Pheochromocytoma (HP:0002666)	2.23053759
50	Absent speech (HP:0001344)	2.21527797
51	J-shaped sella turcica (HP:0002680)	2.20565183
52	Septate vagina (HP:0001153)	2.16489599
53	Anxiety (HP:0000739)	2.16430368
54	Gait imbalance (HP:0002141)	2.15827200
55	Pancreatic fibrosis (HP:0100732)	2.14868191
56	Growth hormone excess (HP:0000845)	2.12724917
57	Limb hypertonia (HP:0002509)	2.12371638
58	Methylmalonic acidemia (HP:0002912)	2.12276498
59	Vascular calcification (HP:0004934)	2.11803450
60	Gingival bleeding (HP:0000225)	2.11791604
61	Abolished electroretinogram (ERG) (HP:0000550)	2.09982344
62	Abnormality of liposaccharide metabolism (HP:0010968)	2.08152002
63	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.08152002
64	Abnormality of glycolipid metabolism (HP:0010969)	2.08152002
65	Congenital primary aphakia (HP:0007707)	2.07816654
66	Hyperlipoproteinemia (HP:0010980)	2.05390476
67	Attenuation of retinal blood vessels (HP:0007843)	2.02178504
68	Neuroendocrine neoplasm (HP:0100634)	2.00912904
69	Hypokinesia (HP:0002375)	1.97342743
70	True hermaphroditism (HP:0010459)	1.94268656
71	Anteriorly placed anus (HP:0001545)	1.93939673
72	Hyperventilation (HP:0002883)	1.93605519
73	Resting tremor (HP:0002322)	1.92357815
74	Diminished movement (HP:0002374)	1.91992824
75	Abnormality of serine family amino acid metabolism (HP:0010894)	1.91876969
76	Abnormality of glycine metabolism (HP:0010895)	1.91876969
77	Neoplasm of the heart (HP:0100544)	1.91764515
78	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.91326946
79	Prolonged QT interval (HP:0001657)	1.91264499
80	Pancreatic cysts (HP:0001737)	1.91051265
81	Tubular atrophy (HP:0000092)	1.90713736
82	Poor suck (HP:0002033)	1.90231811
83	Abnormality of fatty-acid metabolism (HP:0004359)	1.90141576
84	Delayed CNS myelination (HP:0002188)	1.87671798
85	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.87305332
86	Hypoplasia of the fovea (HP:0007750)	1.87305332
87	Nephronophthisis (HP:0000090)	1.80765588
88	Cerebellar dysplasia (HP:0007033)	1.79804038
89	Abnormality of renal excretion (HP:0011036)	1.79569399
90	Renal cortical cysts (HP:0000803)	1.77385057
91	Abnormality of the common coagulation pathway (HP:0010990)	1.75802795
92	Truncus arteriosus (HP:0001660)	1.74738300
93	Insulin-resistant diabetes mellitus (HP:0000831)	1.74295025
94	Occipital encephalocele (HP:0002085)	1.73669194
95	Sensorimotor neuropathy (HP:0007141)	1.73570431
96	Hyperammonemia (HP:0001987)	1.73258309
97	Atrioventricular canal defect (HP:0006695)	1.73079953
98	Cardiovascular calcification (HP:0011915)	1.72824225
99	Unilateral renal agenesis (HP:0000122)	1.72759803
100	Gaze-evoked nystagmus (HP:0000640)	1.72597418

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.81737536
2	WNK3	4.57479692
3	LATS1	4.37072325
4	PRKD3	4.06410451
5	DAPK2	3.36794208
6	FRK	2.83179579
7	MAP3K9	2.73933780
8	UHMK1	2.62492666
9	CASK	2.23159811
10	PINK1	2.18992067
11	NTRK3	2.06520620
12	ARAF	1.97789501
13	MAP2K6	1.80549401
14	PHKG2	1.73907364
15	PHKG1	1.73907364
16	TRPM7	1.68113494
17	STK3	1.65061230
18	TNK2	1.52331651
19	PAK3	1.51430697
20	TRIM28	1.48973150
21	MAPK13	1.46794571
22	PAK6	1.42907577
23	NUAK1	1.41176165
24	CAMK2D	1.40139872
25	MAP3K13	1.36041136
26	GRK1	1.34619239
27	BCKDK	1.31329368
28	MET	1.28259046
29	ACVR1B	1.25139505
30	KSR2	1.24227391
31	BMPR1B	1.17716787
32	NTRK2	1.15823947
33	STK24	1.13687514
34	EPHB1	1.06274403
35	ADRBK2	1.04971885
36	TAOK3	1.03505051
37	PTK2B	0.95932987
38	MST4	0.95398114
39	TIE1	0.91910139
40	PRKCE	0.85656827
41	DYRK1B	0.84177802
42	PDK2	0.82594842
43	CDC42BPA	0.82525874
44	MOS	0.80373671
45	CSNK1G3	0.77924050
46	MYLK	0.72448765
47	TNIK	0.67473613
48	RAF1	0.67431317
49	PRKD2	0.66779891
50	EPHA4	0.66556077
51	CSNK1A1L	0.65467583
52	EPHA3	0.65205561
53	CSNK1G1	0.63349872
54	FER	0.63167253
55	FGFR2	0.61697969
56	STK38L	0.61486585
57	CAMK2G	0.60239172
58	WNK4	0.60194779
59	CSNK1G2	0.58734212
60	CAMK2A	0.58534462
61	TAOK1	0.57980913
62	PRKCG	0.57576801
63	DAPK1	0.55533685
64	STK4	0.54427358
65	PDGFRB	0.53594285
66	MARK1	0.53248479
67	CDK3	0.52281729
68	MAPK15	0.50114271
69	INSRR	0.47718910
70	STK16	0.47717866
71	KSR1	0.47694419
72	MAP3K4	0.47067976
73	ROCK2	0.44487556
74	FGFR4	0.43241969
75	BMX	0.41342639
76	PRKCH	0.40969788
77	NLK	0.40712853
78	MAP2K1	0.40001469
79	CAMK1	0.39144239
80	GSK3A	0.37997125
81	CDK5	0.37648206
82	YES1	0.37071613
83	STK39	0.36739512
84	ERBB2	0.36099477
85	TGFBR1	0.35393423
86	ROCK1	0.34872873
87	CSNK1A1	0.34694602
88	DAPK3	0.34668060
89	CAMK2B	0.34575495
90	PDPK1	0.34079844
91	PRKAA2	0.33684278
92	PRKAA1	0.33558492
93	RPS6KA2	0.33136345
94	PRKG1	0.32976234
95	TYRO3	0.32431108
96	FGFR3	0.31834750
97	CAMK1D	0.31544182
98	PRKACA	0.30302339
99	OBSCN	0.29077390
100	PDK1	0.28678799

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.48204019
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76362263
3	Insulin secretion_Homo sapiens_hsa04911	2.60254547
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.42628645
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.40233317
6	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.37842891
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.18770834
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.15185965
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.10334653
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.99926470
11	Butanoate metabolism_Homo sapiens_hsa00650	1.98907878
12	Sulfur metabolism_Homo sapiens_hsa00920	1.94188222
13	Folate biosynthesis_Homo sapiens_hsa00790	1.91721407
14	Fatty acid elongation_Homo sapiens_hsa00062	1.85979470
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.70847240
16	Fatty acid metabolism_Homo sapiens_hsa01212	1.66133822
17	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.65639666
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.52167268
19	Peroxisome_Homo sapiens_hsa04146	1.49653453
20	Collecting duct acid secretion_Homo sapiens_hsa04966	1.48360872
21	Renin secretion_Homo sapiens_hsa04924	1.47610837
22	Circadian entrainment_Homo sapiens_hsa04713	1.42497373
23	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.42027908
24	Fatty acid degradation_Homo sapiens_hsa00071	1.41832920
25	Sphingolipid metabolism_Homo sapiens_hsa00600	1.39066641
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.33045017
27	Propanoate metabolism_Homo sapiens_hsa00640	1.33044960
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.32092722
29	GABAergic synapse_Homo sapiens_hsa04727	1.31427952
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.25417869
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.23112225
32	Morphine addiction_Homo sapiens_hsa05032	1.20757945
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.19388310
34	Histidine metabolism_Homo sapiens_hsa00340	1.12724213
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05582608
36	Amphetamine addiction_Homo sapiens_hsa05031	1.03714099
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.01217848
38	Glutamatergic synapse_Homo sapiens_hsa04724	1.00756595
39	Arginine and proline metabolism_Homo sapiens_hsa00330	1.00716509
40	Lysosome_Homo sapiens_hsa04142	1.00687543
41	Olfactory transduction_Homo sapiens_hsa04740	1.00495671
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00288658
43	Other glycan degradation_Homo sapiens_hsa00511	0.99304940
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96687484
45	Cocaine addiction_Homo sapiens_hsa05030	0.96653666
46	Mineral absorption_Homo sapiens_hsa04978	0.95840010
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.95591323
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94950564
49	Gastric acid secretion_Homo sapiens_hsa04971	0.94296559
50	Retinol metabolism_Homo sapiens_hsa00830	0.93793342
51	ABC transporters_Homo sapiens_hsa02010	0.92917401
52	Serotonergic synapse_Homo sapiens_hsa04726	0.92319731
53	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.91839177
54	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.91449737
55	Long-term depression_Homo sapiens_hsa04730	0.90611119
56	Bile secretion_Homo sapiens_hsa04976	0.89032646
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88091697
58	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.85960710
59	Glucagon signaling pathway_Homo sapiens_hsa04922	0.85596311
60	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.85265650
61	Salivary secretion_Homo sapiens_hsa04970	0.84817670
62	Glutathione metabolism_Homo sapiens_hsa00480	0.84060622
63	Oxidative phosphorylation_Homo sapiens_hsa00190	0.81225548
64	cAMP signaling pathway_Homo sapiens_hsa04024	0.80803337
65	Vibrio cholerae infection_Homo sapiens_hsa05110	0.80736596
66	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79858208
67	PPAR signaling pathway_Homo sapiens_hsa03320	0.79088253
68	Type I diabetes mellitus_Homo sapiens_hsa04940	0.78218173
69	Complement and coagulation cascades_Homo sapiens_hsa04610	0.77098233
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75136015
71	Arginine biosynthesis_Homo sapiens_hsa00220	0.71209949
72	Nicotine addiction_Homo sapiens_hsa05033	0.69950747
73	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.69537542
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68949072
75	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.67974439
76	Protein export_Homo sapiens_hsa03060	0.66790188
77	Phototransduction_Homo sapiens_hsa04744	0.66609785
78	Circadian rhythm_Homo sapiens_hsa04710	0.63360456
79	Linoleic acid metabolism_Homo sapiens_hsa00591	0.60295990
80	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.59291428
81	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.59031535
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57747983
83	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.57612997
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57369473
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56512337
86	Taste transduction_Homo sapiens_hsa04742	0.54077426
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.52327779
88	Metabolic pathways_Homo sapiens_hsa01100	0.51548264
89	Cholinergic synapse_Homo sapiens_hsa04725	0.50196388
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50119410
91	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.49347235
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.48302472
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.47530073
94	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.44913813
95	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.44812196
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.42541309
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41882801
98	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40455960
99	Renin-angiotensin system_Homo sapiens_hsa04614	0.40252696
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.38588794

CYP4F24P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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