ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular extravasation (GO:0045123)	9.08730164
2	regulation of chemokine biosynthetic process (GO:0045073)	8.04521616
3	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	6.90234937
4	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	6.73486384
5	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	6.65511938
6	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	6.65511938
7	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	6.35365222
8	ether lipid metabolic process (GO:0046485)	6.29766952
9	cellular ketone body metabolic process (GO:0046950)	5.90137999
10	male meiosis (GO:0007140)	5.85882032
11	positive regulation of chemokine biosynthetic process (GO:0045080)	5.60269918
12	neutrophil mediated immunity (GO:0002446)	5.53025910
13	synapsis (GO:0007129)	5.44127784
14	ketone body metabolic process (GO:1902224)	5.31705373
15	microglial cell activation (GO:0001774)	5.19137156
16	regulation of MHC class II biosynthetic process (GO:0045346)	4.93448421
17	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.85280096
18	sensory perception of smell (GO:0007608)	4.76898539
19	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.70878552
20	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	4.69341327
21	modulation of growth of symbiont involved in interaction with host (GO:0044144)	4.69341327
22	regulation of growth of symbiont in host (GO:0044126)	4.69341327
23	negative regulation of growth of symbiont in host (GO:0044130)	4.69341327
24	ventricular system development (GO:0021591)	4.65643775
25	DNA methylation involved in gamete generation (GO:0043046)	4.55979565
26	detection of chemical stimulus involved in sensory perception (GO:0050907)	4.52252611
27	motile cilium assembly (GO:0044458)	4.42482616
28	regulation of phosphoprotein phosphatase activity (GO:0043666)	4.29421529
29	regulation of interleukin-8 biosynthetic process (GO:0045414)	4.25685459
30	epithelial cilium movement (GO:0003351)	4.17983518
31	pyrimidine nucleotide catabolic process (GO:0006244)	4.17713174
32	induction of positive chemotaxis (GO:0050930)	3.99161061
33	spermatid development (GO:0007286)	3.98797769
34	regulation of tumor necrosis factor biosynthetic process (GO:0042534)	3.97841338
35	piRNA metabolic process (GO:0034587)	3.96778566
36	myeloid leukocyte mediated immunity (GO:0002444)	3.93820992
37	negative regulation of chemokine production (GO:0032682)	3.92919542
38	alanine transport (GO:0032328)	3.91713137
39	regulation of oxidative phosphorylation (GO:0002082)	3.89498505
40	diacylglycerol metabolic process (GO:0046339)	3.85888569
41	short-chain fatty acid metabolic process (GO:0046459)	3.81905665
42	sperm motility (GO:0030317)	3.71838053
43	macrophage chemotaxis (GO:0048246)	3.71195725
44	negative regulation of interleukin-8 production (GO:0032717)	3.63720464
45	chromosome organization involved in meiosis (GO:0070192)	3.63093645
46	cilium or flagellum-dependent cell motility (GO:0001539)	3.54352205
47	acrosome reaction (GO:0007340)	3.49388062
48	axonemal dynein complex assembly (GO:0070286)	3.47767955
49	histone deubiquitination (GO:0016578)	3.43629647
50	L-serine transport (GO:0015825)	3.41510598
51	glial cell migration (GO:0008347)	3.38783654
52	TOR signaling (GO:0031929)	3.37949742
53	peroxisome fission (GO:0016559)	3.34467940
54	positive regulation of catecholamine secretion (GO:0033605)	3.33370370
55	centriole assembly (GO:0098534)	3.25333241
56	cilium movement (GO:0003341)	3.25202164
57	detection of chemical stimulus (GO:0009593)	3.23806699
58	glutamine family amino acid catabolic process (GO:0009065)	3.23080682
59	potassium ion export (GO:0071435)	3.22863091
60	glycerol ether metabolic process (GO:0006662)	3.18595598
61	organic cation transport (GO:0015695)	3.17017446
62	tryptophan catabolic process (GO:0006569)	3.12918691
63	indole-containing compound catabolic process (GO:0042436)	3.12918691
64	indolalkylamine catabolic process (GO:0046218)	3.12918691
65	striated muscle atrophy (GO:0014891)	3.12323514
66	inflammatory response to antigenic stimulus (GO:0002437)	3.08839089
67	L-alpha-amino acid transmembrane transport (GO:1902475)	3.08026650
68	regulation of oxidative stress-induced neuron death (GO:1903203)	3.01970138
69	regulation of memory T cell differentiation (GO:0043380)	3.01408413
70	multicellular organism reproduction (GO:0032504)	3.00021046
71	relaxation of smooth muscle (GO:0044557)	2.96362101
72	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.94090882
73	ether metabolic process (GO:0018904)	2.91995195
74	resolution of meiotic recombination intermediates (GO:0000712)	2.91228954
75	C4-dicarboxylate transport (GO:0015740)	2.91086803
76	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition	2.89674909
77	disruption of cells of other organism (GO:0044364)	2.89496899
78	killing of cells of other organism (GO:0031640)	2.89496899
79	nucleosome disassembly (GO:0006337)	2.87853944
80	protein-DNA complex disassembly (GO:0032986)	2.87853944
81	basic amino acid transport (GO:0015802)	2.86644418
82	regulation of autophagic vacuole assembly (GO:2000785)	2.86582347
83	binding of sperm to zona pellucida (GO:0007339)	2.85875408
84	oxidative demethylation (GO:0070989)	2.84896508
85	centriole replication (GO:0007099)	2.83033399
86	serine transport (GO:0032329)	2.81464161
87	glutathione biosynthetic process (GO:0006750)	2.81228098
88	sensory perception of chemical stimulus (GO:0007606)	2.81036453
89	coenzyme catabolic process (GO:0009109)	2.80636366
90	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.80079185
91	polyamine biosynthetic process (GO:0006596)	2.79228862
92	DNA double-strand break processing (GO:0000729)	2.78964522
93	positive regulation of megakaryocyte differentiation (GO:0045654)	2.78870789
94	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.76339938
95	macrophage activation (GO:0042116)	2.76306408
96	activation of protein kinase B activity (GO:0032148)	2.75429275
97	skeletal muscle adaptation (GO:0043501)	2.75243054
98	muscle atrophy (GO:0014889)	2.74471173
99	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2.74231564
100	amino-acid betaine transport (GO:0015838)	2.71747529

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	5.04165913
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.55442235
3	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	4.41046971
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.98182588
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.63525569
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.61989450
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.78988563
8	SCL_19346495_ChIP-Seq_HPC-7_Human	2.66373923
9	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.59499966
10	E2F7_22180533_ChIP-Seq_HELA_Human	2.48939692
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.30730680
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.28492588
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.21324060
14	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.16153148
15	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.88890577
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.86951565
17	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.85154883
18	VDR_22108803_ChIP-Seq_LS180_Human	1.82537951
19	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.80668734
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.74307512
21	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.72951541
22	SPI1_20517297_ChIP-Seq_HL60_Human	1.69228962
23	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.66398653
24	OCT4_20526341_ChIP-Seq_ESCs_Human	1.64676195
25	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.64595462
26	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.62432006
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62261842
28	ERA_21632823_ChIP-Seq_H3396_Human	1.58384565
29	RAC3_21632823_ChIP-Seq_H3396_Human	1.57107591
30	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.54279662
31	CTCF_20526341_ChIP-Seq_ESCs_Human	1.52713640
32	FUS_26573619_Chip-Seq_HEK293_Human	1.52321314
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48853949
34	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.43693801
35	SMC4_20622854_ChIP-Seq_HELA_Human	1.41189438
36	GATA1_22025678_ChIP-Seq_K562_Human	1.38696212
37	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.37800867
38	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.37550215
39	MYC_19829295_ChIP-Seq_ESCs_Human	1.36580969
40	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.36327787
41	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.36148424
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34991342
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.34991342
44	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.34427068
45	SPI1_23127762_ChIP-Seq_K562_Human	1.34133703
46	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33064875
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32817228
48	STAT1_20625510_ChIP-Seq_HELA_Human	1.31525901
49	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.28309661
50	GATA1_19941826_ChIP-Seq_K562_Human	1.26324068
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.24696946
52	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.21160262
53	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21151677
54	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.21107660
55	NCOR_22424771_ChIP-Seq_293T_Human	1.16723847
56	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.16216730
57	PHF8_20622854_ChIP-Seq_HELA_Human	1.15800954
58	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.15230158
59	GATA2_19941826_ChIP-Seq_K562_Human	1.14604599
60	CTCF_27219007_Chip-Seq_Bcells_Human	1.13226123
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12820633
62	ERG_20517297_ChIP-Seq_VCAP_Human	1.10468822
63	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.09896089
64	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.08347887
65	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06445831
66	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.06059525
67	BCAT_22108803_ChIP-Seq_LS180_Human	1.06025200
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05460615
69	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05392237
70	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.04079314
71	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04079314
72	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03574262
73	PHF8_20622853_ChIP-Seq_HELA_Human	1.03307025
74	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.02719754
75	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.02266346
76	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02112855
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02058052
78	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.00839113
79	BCL6_27268052_Chip-Seq_Bcells_Human	0.99597736
80	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.98914460
81	TBL1_22424771_ChIP-Seq_293T_Human	0.98802780
82	P68_20966046_ChIP-Seq_HELA_Human	0.98602561
83	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.98596771
84	MAF_26560356_Chip-Seq_TH2_Human	0.97457087
85	EZH2_22144423_ChIP-Seq_EOC_Human	0.96949907
86	DCP1A_22483619_ChIP-Seq_HELA_Human	0.96862986
87	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.96755399
88	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.96166495
89	E2F1_20622854_ChIP-Seq_HELA_Human	0.95978249
90	STAT1_17558387_ChIP-Seq_HELA_Human	0.95473281
91	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94826624
92	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93412507
93	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.93089636
94	P300_27268052_Chip-Seq_Bcells_Human	0.91134470
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.90697972
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.90106836
97	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.88372937
98	OCT4_19829295_ChIP-Seq_ESCs_Human	0.88191014
99	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.88092411
100	STAT3_23295773_ChIP-Seq_U87_Human	0.87818268

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.83852077
2	MP0003123_paternal_imprinting	3.67025440
3	MP0008877_abnormal_DNA_methylation	3.52146514
4	MP0002132_abnormal_respiratory_system	3.42919032
5	MP0008995_early_reproductive_senescence	3.23178034
6	MP0008004_abnormal_stomach_pH	3.16704642
7	MP0003950_abnormal_plasma_membrane	3.02465206
8	MP0004147_increased_porphyrin_level	2.92145647
9	MP0005377_hearing/vestibular/ear_phenot	2.62989608
10	MP0003878_abnormal_ear_physiology	2.62989608
11	MP0003303_peritoneal_inflammation	2.50649306
12	MP0000015_abnormal_ear_pigmentation	2.44045684
13	MP0005174_abnormal_tail_pigmentation	2.41916116
14	MP0005075_abnormal_melanosome_morpholog	2.35125122
15	MP0009697_abnormal_copulation	2.29059390
16	MP0001929_abnormal_gametogenesis	2.23876638
17	MP0005083_abnormal_biliary_tract	2.14903691
18	MP0003698_abnormal_male_reproductive	2.14424371
19	MP0001545_abnormal_hematopoietic_system	2.10642713
20	MP0005397_hematopoietic_system_phenotyp	2.10642713
21	MP0009840_abnormal_foam_cell	2.05465457
22	MP0005058_abnormal_lysosome_morphology	2.02359473
23	MP0000537_abnormal_urethra_morphology	2.02062208
24	MP0003315_abnormal_perineum_morphology	2.00648770
25	MP0006036_abnormal_mitochondrial_physio	1.93998899
26	MP0001986_abnormal_taste_sensitivity	1.92808776
27	MP0003172_abnormal_lysosome_physiology	1.90409479
28	MP0009278_abnormal_bone_marrow	1.87946356
29	MP0003136_yellow_coat_color	1.75581996
30	MP0001968_abnormal_touch/_nociception	1.62019878
31	MP0003718_maternal_effect	1.60533782
32	MP0004885_abnormal_endolymph	1.60005882
33	MP0002210_abnormal_sex_determination	1.51789140
34	MP0008058_abnormal_DNA_repair	1.51596910
35	MP0008057_abnormal_DNA_replication	1.49165253
36	MP0002160_abnormal_reproductive_system	1.45509188
37	MP0002638_abnormal_pupillary_reflex	1.43997867
38	MP0003121_genomic_imprinting	1.43699989
39	MP0002095_abnormal_skin_pigmentation	1.40671370
40	MP0004084_abnormal_cardiac_muscle	1.39917205
41	MP0009046_muscle_twitch	1.35488406
42	MP0003656_abnormal_erythrocyte_physiolo	1.35233808
43	MP0001661_extended_life_span	1.33657051
44	MP0005464_abnormal_platelet_physiology	1.30726744
45	MP0000678_abnormal_parathyroid_gland	1.27588112
46	MP0001145_abnormal_male_reproductive	1.26647511
47	MP0002161_abnormal_fertility/fecundity	1.21897537
48	MP0008775_abnormal_heart_ventricle	1.20217890
49	MP0001486_abnormal_startle_reflex	1.18586643
50	MP0005647_abnormal_sex_gland	1.12837577
51	MP0000653_abnormal_sex_gland	1.12694596
52	MP0003045_fibrosis	1.09443222
53	MP0001764_abnormal_homeostasis	1.09178269
54	MP0010094_abnormal_chromosome_stability	1.08803576
55	MP0002139_abnormal_hepatobiliary_system	1.07992207
56	MP0001664_abnormal_digestion	1.07741752
57	MP0001984_abnormal_olfaction	1.07175651
58	MP0003806_abnormal_nucleotide_metabolis	1.06558861
59	MP0000372_irregular_coat_pigmentation	1.05059669
60	MP0001727_abnormal_embryo_implantation	1.00512182
61	MP0003786_premature_aging	0.99770583
62	MP0003646_muscle_fatigue	0.98717976
63	MP0003122_maternal_imprinting	0.97424639
64	MP0001905_abnormal_dopamine_level	0.96459489
65	MP0001188_hyperpigmentation	0.96444759
66	MP0003787_abnormal_imprinting	0.91673841
67	MP0005551_abnormal_eye_electrophysiolog	0.91436294
68	MP0004019_abnormal_vitamin_homeostasis	0.91176659
69	MP0005365_abnormal_bile_salt	0.90621827
70	MP0002736_abnormal_nociception_after	0.82243841
71	MP0004036_abnormal_muscle_relaxation	0.80904054
72	MP0008007_abnormal_cellular_replicative	0.79439206
73	MP0004883_abnormal_blood_vessel	0.77086110
74	MP0005409_darkened_coat_color	0.74591737
75	MP0005253_abnormal_eye_physiology	0.73759078
76	MP0006035_abnormal_mitochondrial_morpho	0.72560249
77	MP0005332_abnormal_amino_acid	0.72290905
78	MP0003191_abnormal_cellular_cholesterol	0.71515203
79	MP0004381_abnormal_hair_follicle	0.71230942
80	MP0004215_abnormal_myocardial_fiber	0.71156881
81	MP0002735_abnormal_chemical_nociception	0.69128142
82	MP0005376_homeostasis/metabolism_phenot	0.68660618
83	MP0001529_abnormal_vocalization	0.67036825
84	MP0005266_abnormal_metabolism	0.65930054
85	MP0005360_urolithiasis	0.65546318
86	MP0008875_abnormal_xenobiotic_pharmacok	0.64619098
87	MP0005389_reproductive_system_phenotype	0.60489124
88	MP0004145_abnormal_muscle_electrophysio	0.58501443
89	MP0001963_abnormal_hearing_physiology	0.57030387
90	MP0001502_abnormal_circadian_rhythm	0.56369920
91	MP0003635_abnormal_synaptic_transmissio	0.55168946
92	MP0009745_abnormal_behavioral_response	0.53521065
93	MP0002064_seizures	0.52442425
94	MP0005395_other_phenotype	0.50155499
95	MP0006138_congestive_heart_failure	0.50148150
96	MP0006072_abnormal_retinal_apoptosis	0.48838192
97	MP0002876_abnormal_thyroid_physiology	0.47319080
98	MP0005164_abnormal_response_to	0.46898491
99	MP0003195_calcinosis	0.46680060
100	MP0000681_abnormal_thyroid_gland	0.46030476

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thrombocytosis (HP:0001894)	5.58348234
2	Eosinophilia (HP:0001880)	4.09514510
3	Granulocytopenia (HP:0001913)	4.01598752
4	Resting tremor (HP:0002322)	3.88931403
5	Acanthocytosis (HP:0001927)	3.85499879
6	Absent/shortened dynein arms (HP:0200106)	3.53541502
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.53541502
8	Cerebellar dysplasia (HP:0007033)	3.43961286
9	Type II lissencephaly (HP:0007260)	3.28590117
10	Poikilocytosis (HP:0004447)	3.21737921
11	Pigmentary retinal degeneration (HP:0001146)	3.21272711
12	Gonadal dysgenesis (HP:0000133)	3.17508716
13	Reduced antithrombin III activity (HP:0001976)	3.04291349
14	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.03835518
15	Congenital stationary night blindness (HP:0007642)	2.98468660
16	Abnormal respiratory epithelium morphology (HP:0012253)	2.96966990
17	Abnormal respiratory motile cilium morphology (HP:0005938)	2.96966990
18	Abnormal ciliary motility (HP:0012262)	2.95149941
19	Abnormality of eosinophils (HP:0001879)	2.90226737
20	Abnormal protein glycosylation (HP:0012346)	2.84578832
21	Abnormal glycosylation (HP:0012345)	2.84578832
22	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.84578832
23	Abnormal protein N-linked glycosylation (HP:0012347)	2.84578832
24	Hyperventilation (HP:0002883)	2.79067028
25	Dyskinesia (HP:0100660)	2.77316545
26	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.76041997
27	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.76041997
28	Abnormal sex determination (HP:0012244)	2.73186833
29	Sex reversal (HP:0012245)	2.73186833
30	Ureteral duplication (HP:0000073)	2.66763085
31	Brushfield spots (HP:0001088)	2.65467711
32	Hypoplasia of the uterus (HP:0000013)	2.64954164
33	Hyperthyroidism (HP:0000836)	2.63772297
34	Chromsome breakage (HP:0040012)	2.60616775
35	Truncus arteriosus (HP:0001660)	2.54811785
36	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.53627679
37	Abnormal respiratory motile cilium physiology (HP:0012261)	2.52354562
38	Type I transferrin isoform profile (HP:0003642)	2.52196744
39	Genetic anticipation (HP:0003743)	2.50160950
40	Abnormality of dental color (HP:0011073)	2.46039849
41	Postural instability (HP:0002172)	2.42181680
42	Periodontitis (HP:0000704)	2.39862148
43	Ventricular fibrillation (HP:0001663)	2.37356108
44	Chronic hepatic failure (HP:0100626)	2.37244070
45	Abnormality of the ileum (HP:0001549)	2.37173461
46	Progressive cerebellar ataxia (HP:0002073)	2.36622634
47	Limb hypertonia (HP:0002509)	2.36365909
48	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.35992161
49	Absent thumb (HP:0009777)	2.35175854
50	Decreased central vision (HP:0007663)	2.34118566
51	Abnormality of the columella (HP:0009929)	2.31929751
52	Male pseudohermaphroditism (HP:0000037)	2.31324398
53	Polyneuropathy (HP:0001271)	2.30456899
54	Atonic seizures (HP:0010819)	2.28010138
55	Hypobetalipoproteinemia (HP:0003563)	2.26391546
56	Protruding tongue (HP:0010808)	2.25417818
57	Abnormality of chromosome stability (HP:0003220)	2.25230202
58	Meckel diverticulum (HP:0002245)	2.23689340
59	Difficulty running (HP:0009046)	2.17418723
60	Albinism (HP:0001022)	2.15636498
61	Atelectasis (HP:0100750)	2.11820899
62	Abnormality of macular pigmentation (HP:0008002)	2.10976501
63	Abnormality of pyrimidine metabolism (HP:0004353)	2.10807855
64	Reticulocytosis (HP:0001923)	2.10222122
65	Acute lymphatic leukemia (HP:0006721)	2.03712492
66	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.03105890
67	Abnormality of male internal genitalia (HP:0000022)	2.00859363
68	Duodenal stenosis (HP:0100867)	1.99898485
69	Small intestinal stenosis (HP:0012848)	1.99898485
70	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.98567737
71	Spontaneous abortion (HP:0005268)	1.98222187
72	Macular degeneration (HP:0000608)	1.97907264
73	Infertility (HP:0000789)	1.97762682
74	Papilledema (HP:0001085)	1.97146523
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.96718955
76	Abnormal gallbladder physiology (HP:0012438)	1.95555414
77	Cholecystitis (HP:0001082)	1.95555414
78	Ileus (HP:0002595)	1.95529439
79	Thoracic kyphosis (HP:0002942)	1.95410919
80	Duplicated collecting system (HP:0000081)	1.94930705
81	Abnormality of the preputium (HP:0100587)	1.91441714
82	Mucopolysacchariduria (HP:0008155)	1.89319559
83	Urinary glycosaminoglycan excretion (HP:0003541)	1.89319559
84	Overfolded helix (HP:0000396)	1.88575281
85	Epiphyseal stippling (HP:0010655)	1.86785484
86	Ragged-red muscle fibers (HP:0003200)	1.86604373
87	Acute encephalopathy (HP:0006846)	1.85846294
88	Abnormality of polysaccharide metabolism (HP:0011012)	1.85548099
89	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.85548099
90	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.85548099
91	Abnormality of the duodenum (HP:0002246)	1.84664047
92	Ocular albinism (HP:0001107)	1.84647305
93	Paralysis (HP:0003470)	1.83823951
94	Abnormally folded helix (HP:0008544)	1.83401268
95	Colitis (HP:0002583)	1.83193510
96	Retinal dysplasia (HP:0007973)	1.82816940
97	Abnormality of DNA repair (HP:0003254)	1.82529619
98	Hypergammaglobulinemia (HP:0010702)	1.82336248
99	Pancreatic fibrosis (HP:0100732)	1.81681569
100	Ankle clonus (HP:0011448)	1.80941798

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	6.77957746
2	PDK2	4.08346932
3	MARK3	3.80709664
4	CDK3	3.57670029
5	KSR2	3.10042415
6	NEK2	2.89092930
7	PLK4	2.47544878
8	ZAK	2.11560275
9	MAP3K2	2.10148661
10	TAOK3	1.94429360
11	NTRK3	1.93453639
12	CCNB1	1.92877508
13	PBK	1.80711770
14	RPS6KA5	1.76056788
15	RAF1	1.70205485
16	STK38	1.62529742
17	MAP4K2	1.60220373
18	PTK2B	1.53641041
19	ARAF	1.53557762
20	ADRBK2	1.47295363
21	FRK	1.41624523
22	MAP3K13	1.40501412
23	MYLK	1.39259386
24	CLK1	1.33888499
25	WEE1	1.31422960
26	PRKG2	1.28669626
27	MAP3K1	1.23759786
28	RPS6KA4	1.19318638
29	PLK2	1.16761424
30	PIK3CG	1.11722948
31	IRAK3	1.11001100
32	NEK6	1.02040929
33	MAP3K9	1.00633702
34	MAPK11	0.99713103
35	EIF2AK3	0.99384795
36	OBSCN	0.99080101
37	KSR1	0.97522894
38	TEC	0.95714606
39	STK38L	0.90335538
40	ATR	0.88812066
41	PRKAA1	0.86144207
42	TLK1	0.85763639
43	MAPK15	0.74943100
44	LATS1	0.74755538
45	PIK3CA	0.74530320
46	PRKCQ	0.74526195
47	FGR	0.70597356
48	NME2	0.69097140
49	PDPK1	0.66021232
50	SGK223	0.65700210
51	SGK494	0.65700210
52	EPHB1	0.64439359
53	BMX	0.64251832
54	FES	0.64070330
55	WNK3	0.59236622
56	YES1	0.59023776
57	BTK	0.58718409
58	ERBB3	0.58277722
59	EIF2AK1	0.56949024
60	IRAK2	0.54661652
61	PLK1	0.53141714
62	RET	0.50722356
63	STK4	0.50599963
64	ATM	0.49149190
65	CDC7	0.49135232
66	CDC42BPA	0.49088922
67	RPS6KB1	0.47705571
68	BRSK2	0.47451042
69	ITK	0.46714599
70	CSNK1G2	0.45568624
71	EGFR	0.44625044
72	PDK1	0.43775396
73	TYK2	0.42631479
74	CDK14	0.41954486
75	MAP3K8	0.41336575
76	ZAP70	0.40196011
77	KIT	0.39723621
78	TTK	0.39114074
79	CAMK1	0.38613314
80	MAP2K1	0.38488818
81	PAK1	0.38334414
82	MOS	0.37043217
83	CDK1	0.36749745
84	MAP2K7	0.36213036
85	MAPK12	0.36165298
86	GSK3B	0.34570953
87	CHEK1	0.34131647
88	TNK2	0.32889809
89	CAMK1G	0.31890709
90	CDK5	0.31692766
91	CSF1R	0.31320318
92	HCK	0.30101026
93	SIK2	0.29396968
94	GRK1	0.28908063
95	RIPK4	0.27619800
96	ICK	0.27246515
97	MTOR	0.26271311
98	ROCK1	0.25158076
99	DYRK3	0.23037706
100	CDK2	0.23014327

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.35954020
2	Olfactory transduction_Homo sapiens_hsa04740	4.05063145
3	Butanoate metabolism_Homo sapiens_hsa00650	3.90629773
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.92089642
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.82607438
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.76529768
7	Other glycan degradation_Homo sapiens_hsa00511	2.62479060
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.58570955
9	Propanoate metabolism_Homo sapiens_hsa00640	2.56930514
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.24275207
11	Homologous recombination_Homo sapiens_hsa03440	1.99181927
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.87075998
13	Gap junction_Homo sapiens_hsa04540	1.86083495
14	Pyruvate metabolism_Homo sapiens_hsa00620	1.80231158
15	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.75651939
16	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.61181518
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.59317645
18	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.59044362
19	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.57365610
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.52286159
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.50157044
22	Base excision repair_Homo sapiens_hsa03410	1.49662623
23	Glutathione metabolism_Homo sapiens_hsa00480	1.42121448
24	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.41937048
25	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.32373651
26	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.32109796
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.31408285
28	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.27041753
29	DNA replication_Homo sapiens_hsa03030	1.23909330
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.21124693
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.18443351
32	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.15633206
33	Sphingolipid metabolism_Homo sapiens_hsa00600	1.13784688
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.11101712
35	Fatty acid elongation_Homo sapiens_hsa00062	1.05777190
36	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.04637209
37	Phagosome_Homo sapiens_hsa04145	1.03454075
38	Renin-angiotensin system_Homo sapiens_hsa04614	0.97449576
39	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.94519008
40	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93897746
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.92908620
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.89763934
43	Peroxisome_Homo sapiens_hsa04146	0.89454922
44	Fatty acid degradation_Homo sapiens_hsa00071	0.88719081
45	Purine metabolism_Homo sapiens_hsa00230	0.88594725
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83037943
47	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.82879099
48	Taste transduction_Homo sapiens_hsa04742	0.81218489
49	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80404290
50	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76662336
51	PPAR signaling pathway_Homo sapiens_hsa03320	0.75309586
52	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.73654598
53	Apoptosis_Homo sapiens_hsa04210	0.73118413
54	Arginine and proline metabolism_Homo sapiens_hsa00330	0.72201093
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72139333
56	Metabolic pathways_Homo sapiens_hsa01100	0.70684811
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.69474827
58	Mismatch repair_Homo sapiens_hsa03430	0.68912272
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.66771891
60	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.66249393
61	Basal transcription factors_Homo sapiens_hsa03022	0.65685167
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65324580
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.62681611
64	Endometrial cancer_Homo sapiens_hsa05213	0.61175251
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.60324160
66	Asthma_Homo sapiens_hsa05310	0.60273952
67	Carbon metabolism_Homo sapiens_hsa01200	0.59534312
68	Oocyte meiosis_Homo sapiens_hsa04114	0.58217261
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57675157
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.57065688
71	Lysosome_Homo sapiens_hsa04142	0.54475622
72	Retinol metabolism_Homo sapiens_hsa00830	0.53535421
73	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.52186185
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.52001590
75	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.50630446
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50558079
77	One carbon pool by folate_Homo sapiens_hsa00670	0.49284694
78	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49142988
79	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.49031903
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.48962432
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47354618
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.45462137
83	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45125720
84	Type II diabetes mellitus_Homo sapiens_hsa04930	0.43932861
85	Lysine degradation_Homo sapiens_hsa00310	0.43340422
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39611990
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.39423242
88	Linoleic acid metabolism_Homo sapiens_hsa00591	0.39073702
89	Acute myeloid leukemia_Homo sapiens_hsa05221	0.38879712
90	ABC transporters_Homo sapiens_hsa02010	0.38253994
91	Complement and coagulation cascades_Homo sapiens_hsa04610	0.35198807
92	Alcoholism_Homo sapiens_hsa05034	0.33545638
93	Oxidative phosphorylation_Homo sapiens_hsa00190	0.33170651
94	Regulation of autophagy_Homo sapiens_hsa04140	0.30796624
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.29344523
96	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.24685559
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.22127568
98	Pentose phosphate pathway_Homo sapiens_hsa00030	0.21698352
99	Rheumatoid arthritis_Homo sapiens_hsa05323	0.20584747
100	mTOR signaling pathway_Homo sapiens_hsa04150	0.20065970

CYP4F25P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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