CYP4F29P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57039060
2positive regulation of gamma-delta T cell activation (GO:0046645)5.31161448
3regulation of B cell receptor signaling pathway (GO:0050855)5.08353677
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.06621567
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.80223970
6negative regulation of cell killing (GO:0031342)4.80223970
7antigen processing and presentation of endogenous antigen (GO:0019883)4.76628549
8regulation of histone H3-K27 methylation (GO:0061085)4.75830661
9peptide cross-linking (GO:0018149)4.64319542
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.56217156
11positive thymic T cell selection (GO:0045059)4.43629005
12B cell receptor signaling pathway (GO:0050853)4.39933813
13cilium or flagellum-dependent cell motility (GO:0001539)4.37954304
14motile cilium assembly (GO:0044458)4.35597118
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.35012554
16regulation of gamma-delta T cell differentiation (GO:0045586)4.26035560
17histone H3-K36 demethylation (GO:0070544)4.21949936
18axonemal dynein complex assembly (GO:0070286)4.11066654
19regulation of gamma-delta T cell activation (GO:0046643)4.07920044
20regulation of ARF GTPase activity (GO:0032312)4.06881246
21detection of bacterium (GO:0016045)3.82730381
22thymic T cell selection (GO:0045061)3.80201312
23leukocyte aggregation (GO:0070486)3.77327961
24positive T cell selection (GO:0043368)3.70321506
25fusion of sperm to egg plasma membrane (GO:0007342)3.68154948
26regulation of B cell differentiation (GO:0045577)3.64424555
27regulation of T-helper 2 cell differentiation (GO:0045628)3.59904878
28positive regulation of B cell differentiation (GO:0045579)3.56518788
29phosphatidylethanolamine biosynthetic process (GO:0006646)3.55088481
30detection of other organism (GO:0098543)3.53414492
31T cell selection (GO:0045058)3.53045479
32potassium ion export (GO:0071435)3.49473704
33response to interleukin-15 (GO:0070672)3.48862226
34macrophage activation involved in immune response (GO:0002281)3.40342470
35keratinization (GO:0031424)3.37972265
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32985806
37sperm motility (GO:0030317)3.27396120
38positive regulation of granulocyte differentiation (GO:0030854)3.26504421
39negative T cell selection (GO:0043383)3.25199619
40detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.23781118
41negative thymic T cell selection (GO:0045060)3.22912442
42regulation of mast cell degranulation (GO:0043304)3.19898978
43cellular response to interleukin-15 (GO:0071350)3.17835748
44phosphatidylethanolamine metabolic process (GO:0046337)3.17239697
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.16932133
46production of molecular mediator involved in inflammatory response (GO:0002532)3.13887099
47acrosome reaction (GO:0007340)3.08832123
48negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05768023
49negative regulation of T-helper cell differentiation (GO:0045623)3.05768023
50positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04047778
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.03399521
52immunoglobulin mediated immune response (GO:0016064)3.02911181
53mannose metabolic process (GO:0006013)3.02091324
54negative regulation of alpha-beta T cell activation (GO:0046636)3.01898017
55cilium movement (GO:0003341)3.01204908
56positive regulation of T cell mediated cytotoxicity (GO:0001916)3.00676544
57positive regulation of type 2 immune response (GO:0002830)3.00535009
58defense response to protozoan (GO:0042832)2.99892220
59mast cell activation involved in immune response (GO:0002279)2.98646703
60mast cell degranulation (GO:0043303)2.98646703
61detection of external biotic stimulus (GO:0098581)2.96210131
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.96163408
63epithelial cilium movement (GO:0003351)2.96121532
64centriole assembly (GO:0098534)2.95723057
65regulation of granulocyte differentiation (GO:0030852)2.94274922
66multicellular organism reproduction (GO:0032504)2.94109869
67regulation of mast cell activation involved in immune response (GO:0033006)2.93439960
68positive regulation by symbiont of host defense response (GO:0052509)2.92068847
69modulation by symbiont of host defense response (GO:0052031)2.92068847
70modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92068847
71modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92068847
72positive regulation by organism of defense response of other organism involved in symbiotic interact2.92068847
73modulation by symbiont of host immune response (GO:0052553)2.92068847
74neutrophil activation involved in immune response (GO:0002283)2.90861438
75positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.86989530
76regulation of T cell mediated cytotoxicity (GO:0001914)2.85512271
77myeloid cell activation involved in immune response (GO:0002275)2.84930644
78negative regulation of alpha-beta T cell differentiation (GO:0046639)2.83928998
79positive regulation of interleukin-17 production (GO:0032740)2.83103726
80negative regulation of phagocytosis (GO:0050765)2.81854417
81leukocyte degranulation (GO:0043299)2.81741203
82regulation of interleukin-4 production (GO:0032673)2.81710826
83histone H3 deacetylation (GO:0070932)2.81240402
84poly(A)+ mRNA export from nucleus (GO:0016973)2.80355042
85negative regulation of stress fiber assembly (GO:0051497)2.80252923
86positive regulation of alpha-beta T cell differentiation (GO:0046638)2.80007079
87regulation of protein glycosylation (GO:0060049)2.78885167
88positive regulation of Rab GTPase activity (GO:0032851)2.78789227
89regulation of Rab GTPase activity (GO:0032313)2.78789227
90regulation of alpha-beta T cell proliferation (GO:0046640)2.77487035
91mast cell activation (GO:0045576)2.77307924
92positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.76486215
93male sex determination (GO:0030238)2.76421438
94positive regulation of Rap GTPase activity (GO:0032854)2.76028142
95antigen receptor-mediated signaling pathway (GO:0050851)2.75721709
96regulation of regulatory T cell differentiation (GO:0045589)2.74023582
97negative regulation of leukocyte mediated immunity (GO:0002704)2.73176146
98histone H3-K9 modification (GO:0061647)2.70590460
99CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.68190327
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.67294917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.40918883
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.29249009
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.22650992
4E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.54988675
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.39290287
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36599868
7RUNX_20019798_ChIP-Seq_JUKART_Human2.25718854
8SPI1_23127762_ChIP-Seq_K562_Human2.21680473
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18094109
10UTX_26944678_Chip-Seq_JUKART_Human2.17623115
11MYB_26560356_Chip-Seq_TH2_Human2.16292545
12MAF_26560356_Chip-Seq_TH2_Human2.15101980
13MAF_26560356_Chip-Seq_TH1_Human2.12482596
14LXR_22292898_ChIP-Seq_THP-1_Human2.11551580
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.10985150
16KDM2B_26808549_Chip-Seq_DND41_Human2.10959554
17MYB_26560356_Chip-Seq_TH1_Human2.07582080
18SMC4_20622854_ChIP-Seq_HELA_Human2.06792263
19SCL_19346495_ChIP-Seq_HPC-7_Human2.04931196
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.02594077
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00653330
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.98105923
23BCOR_27268052_Chip-Seq_Bcells_Human1.97799610
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94104921
25BCL6_27268052_Chip-Seq_Bcells_Human1.93261857
26VDR_21846776_ChIP-Seq_THP-1_Human1.89071338
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87655213
28EZH2_22144423_ChIP-Seq_EOC_Human1.87545128
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87329292
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.84672160
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.79973358
32E2F1_20622854_ChIP-Seq_HELA_Human1.79302216
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76120315
34P68_20966046_ChIP-Seq_HELA_Human1.71895512
35MYC_22102868_ChIP-Seq_BL_Human1.69900869
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.69332067
37GATA1_19941826_ChIP-Seq_K562_Human1.68398808
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67591446
39TCF7_22412390_ChIP-Seq_EML_Mouse1.66742028
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65143013
41GATA3_27048872_Chip-Seq_THYMUS_Human1.64318727
42P300_27268052_Chip-Seq_Bcells_Human1.63422029
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63045189
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.61415819
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.61190025
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59493420
47VDR_24763502_ChIP-Seq_THP-1_Human1.58284707
48PHF8_20622854_ChIP-Seq_HELA_Human1.57662770
49SPI1_23547873_ChIP-Seq_NB4_Human1.57273703
50CTCF_27219007_Chip-Seq_Bcells_Human1.56829181
51CTCF_20526341_ChIP-Seq_ESCs_Human1.56818375
52SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.52648997
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52606531
54TP63_22573176_ChIP-Seq_HFKS_Human1.52168856
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52166309
56CTCF_21964334_ChIP-Seq_BJAB-B_Human1.50899730
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47376257
58RUNX1_27514584_Chip-Seq_MCF-7_Human1.46331047
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44813018
60RAC3_21632823_ChIP-Seq_H3396_Human1.39666245
61NANOG_20526341_ChIP-Seq_ESCs_Human1.39387648
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.37882436
63NCOR1_26117541_ChIP-Seq_K562_Human1.36913890
64CIITA_25753668_ChIP-Seq_RAJI_Human1.35075208
65GATA2_19941826_ChIP-Seq_K562_Human1.34652066
66STAT1_20625510_ChIP-Seq_HELA_Human1.34626077
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33554696
68ERA_21632823_ChIP-Seq_H3396_Human1.33359784
69SA1_27219007_Chip-Seq_Bcells_Human1.33087037
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.31274201
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30409327
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.29348745
73AR_21572438_ChIP-Seq_LNCaP_Human1.28499406
74CREB1_26743006_Chip-Seq_LNCaP_Human1.27114902
75DROSHA_22980978_ChIP-Seq_HELA_Human1.26939251
76SPI1_20517297_ChIP-Seq_HL60_Human1.25490287
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24059656
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23909741
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22988143
80RACK7_27058665_Chip-Seq_MCF-7_Human1.22398670
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20698456
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.20341208
83CTCF_21964334_Chip-Seq_Bcells_Human1.17754022
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15196874
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.14876138
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14366653
87GATA3_26560356_Chip-Seq_TH2_Human1.14292805
88P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14282887
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13887092
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.13382754
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10920899
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10889376
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05198450
94OCT4_20526341_ChIP-Seq_ESCs_Human1.04923820
95BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.03492966
96WDR5_24793694_ChIP-Seq_LNCAP_Human1.03206021
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02986463
98KDM2B_26808549_Chip-Seq_K562_Human1.01747162
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01613760
100OCT4_19829295_ChIP-Seq_ESCs_Human1.01443630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002132_abnormal_respiratory_system4.27894271
2MP0005410_abnormal_fertilization3.42098943
3MP0003763_abnormal_thymus_physiology3.13967059
4MP0010234_abnormal_vibrissa_follicle3.07524826
5MP0004043_abnormal_pH_regulation2.88755161
6MP0001835_abnormal_antigen_presentation2.86107187
7MP0005083_abnormal_biliary_tract2.72740118
8MP0003436_decreased_susceptibility_to2.64403534
9MP0001800_abnormal_humoral_immune2.58194308
10MP0004381_abnormal_hair_follicle2.56019200
11MP0003303_peritoneal_inflammation2.53705053
12MP0003724_increased_susceptibility_to2.47266146
13MP0001873_stomach_inflammation2.43456931
14MP0001790_abnormal_immune_system2.26157514
15MP0005387_immune_system_phenotype2.26157514
16MP0005671_abnormal_response_to2.21719048
17MP0005000_abnormal_immune_tolerance2.13825874
18MP0002420_abnormal_adaptive_immunity2.11598800
19MP0000465_gastrointestinal_hemorrhage2.09841675
20MP0001819_abnormal_immune_cell2.08861685
21MP0002723_abnormal_immune_serum2.07791518
22MP0003878_abnormal_ear_physiology2.06743206
23MP0005377_hearing/vestibular/ear_phenot2.06743206
24MP0002452_abnormal_antigen_presenting1.95080949
25MP0005025_abnormal_response_to1.92240838
26MP0008004_abnormal_stomach_pH1.91295532
27MP0005397_hematopoietic_system_phenotyp1.91199902
28MP0001545_abnormal_hematopoietic_system1.91199902
29MP0002398_abnormal_bone_marrow1.80546213
30MP0002796_impaired_skin_barrier1.78039860
31MP0002419_abnormal_innate_immunity1.74102326
32MP0009785_altered_susceptibility_to1.73254174
33MP0005075_abnormal_melanosome_morpholog1.67754122
34MP0000685_abnormal_immune_system1.65517112
35MP0009278_abnormal_bone_marrow1.65140972
36MP0000703_abnormal_thymus_morphology1.64712679
37MP0000716_abnormal_immune_system1.64409744
38MP0002653_abnormal_ependyma_morphology1.59017621
39MP0000678_abnormal_parathyroid_gland1.56843455
40MP0002405_respiratory_system_inflammati1.53884448
41MP0005464_abnormal_platelet_physiology1.53190283
42MP0008995_early_reproductive_senescence1.50584489
43MP0002722_abnormal_immune_system1.49085499
44MP0003698_abnormal_male_reproductive1.48388395
45MP0006082_CNS_inflammation1.40090291
46MP0003172_abnormal_lysosome_physiology1.39875210
47MP0002138_abnormal_hepatobiliary_system1.34514867
48MP0000689_abnormal_spleen_morphology1.33551130
49MP0001929_abnormal_gametogenesis1.32395567
50MP0002429_abnormal_blood_cell1.31598740
51MP0010155_abnormal_intestine_physiology1.30881110
52MP0003011_delayed_dark_adaptation1.27316543
53MP0000467_abnormal_esophagus_morphology1.26525109
54MP0002095_abnormal_skin_pigmentation1.24500588
55MP0000015_abnormal_ear_pigmentation1.23956136
56MP0005451_abnormal_body_composition1.21828071
57MP0002277_abnormal_respiratory_mucosa1.20585934
58MP0000371_diluted_coat_color1.20110393
59MP0005310_abnormal_salivary_gland1.18364190
60MP0005670_abnormal_white_adipose1.16836460
61MP0004947_skin_inflammation1.15510447
62MP0003806_abnormal_nucleotide_metabolis1.14925456
63MP0004883_abnormal_blood_vessel1.13511160
64MP0001851_eye_inflammation1.12013758
65MP0001764_abnormal_homeostasis1.08868831
66MP0000569_abnormal_digit_pigmentation1.04104554
67MP0000470_abnormal_stomach_morphology1.04065049
68MP0003191_abnormal_cellular_cholesterol1.01101287
69MP0001845_abnormal_inflammatory_respons1.00880338
70MP0005166_decreased_susceptibility_to0.98384958
71MP0002148_abnormal_hypersensitivity_rea0.97603805
72MP0001765_abnormal_ion_homeostasis0.96413330
73MP0004264_abnormal_extraembryonic_tissu0.95308482
74MP0001533_abnormal_skeleton_physiology0.91584629
75MP0003866_abnormal_defecation0.87467404
76MP0008961_abnormal_basal_metabolism0.86785200
77MP0005501_abnormal_skin_physiology0.85895295
78MP0009333_abnormal_splenocyte_physiolog0.85157360
79MP0001663_abnormal_digestive_system0.84362740
80MP0008469_abnormal_protein_level0.83565464
81MP0006036_abnormal_mitochondrial_physio0.82426436
82MP0003283_abnormal_digestive_organ0.80495798
83MP0009115_abnormal_fat_cell0.78195299
84MP0005058_abnormal_lysosome_morphology0.75437820
85MP0003453_abnormal_keratinocyte_physiol0.75261520
86MP0004808_abnormal_hematopoietic_stem0.73741089
87MP0009840_abnormal_foam_cell0.72664879
88MP0003045_fibrosis0.69809189
89MP0006035_abnormal_mitochondrial_morpho0.67806823
90MP0002933_joint_inflammation0.66358682
91MP0005535_abnormal_body_temperature0.66245535
92MP0001145_abnormal_male_reproductive0.64816436
93MP0002161_abnormal_fertility/fecundity0.64273646
94MP0005164_abnormal_response_to0.64270995
95MP0002210_abnormal_sex_determination0.62947948
96MP0000490_abnormal_crypts_of0.62499559
97MP0005666_abnormal_adipose_tissue0.62167328
98MP0003183_abnormal_peptide_metabolism0.59493751
99MP0000858_altered_metastatic_potential0.59286384
100MP0005381_digestive/alimentary_phenotyp0.57852578

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)5.09608993
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.09608993
3Nasal polyposis (HP:0100582)4.84653322
4Colitis (HP:0002583)4.31574748
5Oral leukoplakia (HP:0002745)4.27433001
6Abnormality of the nasal mucosa (HP:0000433)4.13499465
7Abnormal ciliary motility (HP:0012262)4.08382719
8Gastrointestinal inflammation (HP:0004386)3.96555629
9Inflammation of the large intestine (HP:0002037)3.92323632
10Type II lissencephaly (HP:0007260)3.90892584
11Pustule (HP:0200039)3.80723009
12Abnormal respiratory epithelium morphology (HP:0012253)3.76090281
13Abnormal respiratory motile cilium morphology (HP:0005938)3.76090281
14Increased IgE level (HP:0003212)3.74697938
15Recurrent bacterial skin infections (HP:0005406)3.72918986
16Abnormal respiratory motile cilium physiology (HP:0012261)3.64479369
17Panhypogammaglobulinemia (HP:0003139)3.57202896
18Gastrointestinal stroma tumor (HP:0100723)3.55074674
19Eczematoid dermatitis (HP:0000976)3.50516863
20Recurrent sinusitis (HP:0011108)3.50496578
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.44202117
22Chronic obstructive pulmonary disease (HP:0006510)3.30720558
23Obstructive lung disease (HP:0006536)3.30720558
24Retinal dysplasia (HP:0007973)3.28233768
25Recurrent abscess formation (HP:0002722)3.23934505
26Prolonged bleeding time (HP:0003010)3.13053120
27Meningitis (HP:0001287)3.07080831
28Vasculitis (HP:0002633)3.06838578
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.00479331
30Severe visual impairment (HP:0001141)2.81662016
31Myositis (HP:0100614)2.76321727
32Seborrheic dermatitis (HP:0001051)2.75480655
33Bronchiectasis (HP:0002110)2.74985515
34Recurrent fungal infections (HP:0002841)2.73338140
35Abnormality of macrophages (HP:0004311)2.68471705
36Infertility (HP:0000789)2.63618012
37Agammaglobulinemia (HP:0004432)2.61040679
38Papilledema (HP:0001085)2.60561928
39Male infertility (HP:0003251)2.54801976
40Gonadal dysgenesis (HP:0000133)2.52782390
41Gastrointestinal infarctions (HP:0005244)2.51394402
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51225230
43Recurrent otitis media (HP:0000403)2.49376295
44Abnormality of the columella (HP:0009929)2.48543098
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47999773
46Lip pit (HP:0100267)2.46623958
47Granulocytopenia (HP:0001913)2.45038144
48Emphysema (HP:0002097)2.41455909
49Recurrent skin infections (HP:0001581)2.40523401
50Lymphopenia (HP:0001888)2.40482940
51Ventricular fibrillation (HP:0001663)2.37341917
52Papilloma (HP:0012740)2.36024356
53Verrucae (HP:0200043)2.36024356
54Urticaria (HP:0001025)2.34887308
55Chronic sinusitis (HP:0011109)2.31536950
56Recurrent gram-negative bacterial infections (HP:0005420)2.27154776
57Rhinitis (HP:0012384)2.26682834
58Optic neuritis (HP:0100653)2.23882408
59Retrobulbar optic neuritis (HP:0100654)2.23882408
60Restrictive lung disease (HP:0002091)2.22281998
61Chronic mucocutaneous candidiasis (HP:0002728)2.21408976
62Recurrent cutaneous fungal infections (HP:0011370)2.21408976
63Resting tremor (HP:0002322)2.20143582
64Encephalitis (HP:0002383)2.19615676
65Orchitis (HP:0100796)2.19368166
66Elevated erythrocyte sedimentation rate (HP:0003565)2.16187261
67Abnormality of the fingertips (HP:0001211)2.15418310
68Abnormality of nail color (HP:0100643)2.14932077
69Calf muscle hypertrophy (HP:0008981)2.14206871
70Recurrent viral infections (HP:0004429)2.12254741
71Stomatitis (HP:0010280)2.09261142
72Postural instability (HP:0002172)2.08165720
73Epistaxis (HP:0000421)2.08074367
74Spontaneous hematomas (HP:0007420)2.07663185
75Abnormal rod and cone electroretinograms (HP:0008323)2.06613594
76Severe combined immunodeficiency (HP:0004430)2.05996655
77Erythroderma (HP:0001019)2.05933574
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.05893192
79Keratoconjunctivitis sicca (HP:0001097)2.04627114
80Petechiae (HP:0000967)2.03695157
81Stomach cancer (HP:0012126)2.02272895
82Abnormality of DNA repair (HP:0003254)2.00892735
83Gangrene (HP:0100758)1.98776145
84Recurrent pneumonia (HP:0006532)1.97865740
85Recurrent bronchitis (HP:0002837)1.97508118
86Abnormality of the heme biosynthetic pathway (HP:0010472)1.96088569
87Basal cell carcinoma (HP:0002671)1.91829802
88Chest pain (HP:0100749)1.90190286
89Facial hemangioma (HP:0000329)1.88258755
90Bronchitis (HP:0012387)1.87716126
91Keratoconjunctivitis (HP:0001096)1.86836523
92Chronic otitis media (HP:0000389)1.85867655
93Palmoplantar hyperkeratosis (HP:0000972)1.85502006
94Mediastinal lymphadenopathy (HP:0100721)1.81779946
95Abnormality of T cells (HP:0002843)1.81645579
96Easy fatigability (HP:0003388)1.80963190
97Muscle hypertrophy of the lower extremities (HP:0008968)1.80931230
98Cellulitis (HP:0100658)1.80243230
99Sepsis (HP:0100806)1.80177106
100Hypertensive crisis (HP:0100735)1.77758649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.31425212
2RIPK44.05456390
3MARK33.25124960
4PINK12.65676238
5NME22.55079204
6TNK22.53612062
7GRK62.33816592
8BTK2.16714917
9TXK2.14803822
10BLK2.12103638
11TRIB32.09672618
12MAP3K131.90494805
13MAPK151.84837501
14TYK21.84664622
15ZAP701.80715281
16IRAK41.79214798
17CDK191.73219260
18MAP3K31.67347995
19MAP3K21.66205433
20MAP3K101.62935597
21ERN11.51575511
22PRPF4B1.50528898
23HCK1.48785553
24FES1.47104867
25MARK21.46453052
26ITK1.45383041
27CLK11.41503467
28SIK21.40313590
29CSK1.37135638
30CDK31.33706469
31TAOK11.33020338
32KSR21.32406170
33SYK1.30311228
34MAP4K21.27559028
35PDPK11.26850325
36PDK11.26774146
37MAP2K31.24275371
38MAP3K71.22616267
39STK381.22588847
40PRKCQ1.17032976
41JAK31.16284046
42MAP3K11.13637217
43TAOK31.13173283
44TEC1.12654659
45CDK41.12244807
46LATS11.07867604
47NTRK31.07778237
48SIK31.06076723
49PLK41.02821148
50NME11.02636056
51MELK0.99554202
52NEK20.96300200
53PNCK0.94466299
54FGR0.88362658
55MAPK120.86834786
56PRKG20.85120275
57BMPR20.83105441
58JAK20.82746553
59LYN0.80622581
60MAP2K60.79722604
61BRD40.79255908
62CDC42BPA0.78280730
63PTK60.76849064
64HIPK20.75928954
65PTK2B0.71413787
66LCK0.71014689
67SIK10.68413668
68NTRK20.66449876
69EPHB10.64809754
70NEK60.56735523
71IKBKE0.55257487
72IRAK20.54329944
73DYRK30.51889703
74JAK10.51478474
75MYLK0.50704721
76MAPK110.49700063
77LMTK20.49532814
78RET0.48432077
79IKBKB0.47710861
80LRRK20.47442073
81STK100.46151675
82BMX0.45558908
83MAPKAPK30.45021252
84ERBB30.44803670
85SGK2230.44533644
86SGK4940.44533644
87ARAF0.44152935
88ICK0.42620197
89CSF1R0.39307779
90RPS6KB10.38407413
91TBK10.37922395
92PIM10.36234628
93RPS6KA10.35233723
94MATK0.34299088
95STK110.33722562
96MAP3K80.31165800
97GRK10.30688779
98MAP3K60.30552107
99PIK3CG0.30228102
100RPS6KC10.30155222

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.47509568
2Autoimmune thyroid disease_Homo sapiens_hsa053203.03939494
3Allograft rejection_Homo sapiens_hsa053303.01183788
4B cell receptor signaling pathway_Homo sapiens_hsa046622.66872331
5Primary immunodeficiency_Homo sapiens_hsa053402.61605831
6Olfactory transduction_Homo sapiens_hsa047402.40244006
7Leishmaniasis_Homo sapiens_hsa051402.30045387
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.27968805
9Type I diabetes mellitus_Homo sapiens_hsa049402.15673521
10Acute myeloid leukemia_Homo sapiens_hsa052212.01785777
11T cell receptor signaling pathway_Homo sapiens_hsa046601.98923847
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.98758458
13Staphylococcus aureus infection_Homo sapiens_hsa051501.97443730
14Antigen processing and presentation_Homo sapiens_hsa046121.96663395
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.84475090
16Osteoclast differentiation_Homo sapiens_hsa043801.81712837
17Asthma_Homo sapiens_hsa053101.76092847
18Viral myocarditis_Homo sapiens_hsa054161.69264640
19Hematopoietic cell lineage_Homo sapiens_hsa046401.62623980
20Herpes simplex infection_Homo sapiens_hsa051681.47155512
21Tuberculosis_Homo sapiens_hsa051521.44651815
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.44184886
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35086550
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24705378
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24605606
26Toxoplasmosis_Homo sapiens_hsa051451.24038581
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20090099
28Influenza A_Homo sapiens_hsa051641.15237522
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.13034516
30VEGF signaling pathway_Homo sapiens_hsa043701.12782087
31Phagosome_Homo sapiens_hsa041451.12383734
32Non-small cell lung cancer_Homo sapiens_hsa052231.11030892
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.10758273
34Measles_Homo sapiens_hsa051621.07532777
35Chemokine signaling pathway_Homo sapiens_hsa040621.05170607
36Choline metabolism in cancer_Homo sapiens_hsa052311.04208364
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02407112
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02378149
39Dorso-ventral axis formation_Homo sapiens_hsa043201.01156303
40Apoptosis_Homo sapiens_hsa042101.00742498
41Other glycan degradation_Homo sapiens_hsa005110.99358588
42Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98033516
43Sphingolipid signaling pathway_Homo sapiens_hsa040710.94475236
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94047075
45Platelet activation_Homo sapiens_hsa046110.90431536
46ABC transporters_Homo sapiens_hsa020100.89585844
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88290401
48Pentose phosphate pathway_Homo sapiens_hsa000300.88203106
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85500481
50Inositol phosphate metabolism_Homo sapiens_hsa005620.83002300
51Rheumatoid arthritis_Homo sapiens_hsa053230.79190158
52Endometrial cancer_Homo sapiens_hsa052130.78728503
53mTOR signaling pathway_Homo sapiens_hsa041500.75539790
54Hepatitis B_Homo sapiens_hsa051610.74322981
55Chronic myeloid leukemia_Homo sapiens_hsa052200.74172886
56Endocytosis_Homo sapiens_hsa041440.73886300
57Regulation of autophagy_Homo sapiens_hsa041400.70546612
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68044959
59Salivary secretion_Homo sapiens_hsa049700.67492509
60HTLV-I infection_Homo sapiens_hsa051660.66717144
61Malaria_Homo sapiens_hsa051440.65749207
62Gap junction_Homo sapiens_hsa045400.64096293
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63010815
64ErbB signaling pathway_Homo sapiens_hsa040120.62837356
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.62348029
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.61453719
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.60499312
68Long-term potentiation_Homo sapiens_hsa047200.57658858
69Glycerolipid metabolism_Homo sapiens_hsa005610.56355196
70Hepatitis C_Homo sapiens_hsa051600.55535064
71Epstein-Barr virus infection_Homo sapiens_hsa051690.55379517
72MAPK signaling pathway_Homo sapiens_hsa040100.55268999
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54999799
74Gastric acid secretion_Homo sapiens_hsa049710.54932196
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54898316
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.54819781
77Notch signaling pathway_Homo sapiens_hsa043300.51666742
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51394692
79Chemical carcinogenesis_Homo sapiens_hsa052040.51255948
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51177719
81African trypanosomiasis_Homo sapiens_hsa051430.47633751
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46573463
83Tyrosine metabolism_Homo sapiens_hsa003500.46333589
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46011798
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44918458
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44527578
87Estrogen signaling pathway_Homo sapiens_hsa049150.43961134
88GnRH signaling pathway_Homo sapiens_hsa049120.42592916
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.42095041
90Viral carcinogenesis_Homo sapiens_hsa052030.40687201
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40667985
92Insulin signaling pathway_Homo sapiens_hsa049100.38503278
93Pancreatic cancer_Homo sapiens_hsa052120.38070330
94TNF signaling pathway_Homo sapiens_hsa046680.38051041
95FoxO signaling pathway_Homo sapiens_hsa040680.38014681
96Prolactin signaling pathway_Homo sapiens_hsa049170.37296492
97Phenylalanine metabolism_Homo sapiens_hsa003600.37238037
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36392561
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34958380
100Renin secretion_Homo sapiens_hsa049240.34161958

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