CYP4F3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)5.84032301
2drug catabolic process (GO:0042737)5.44541671
3epoxygenase P450 pathway (GO:0019373)5.15507540
4complement activation, alternative pathway (GO:0006957)5.10552388
5detection of molecule of bacterial origin (GO:0032490)5.06482623
6disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.91744711
7killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.91744711
8omega-hydroxylase P450 pathway (GO:0097267)4.88145920
9regulation of fibrinolysis (GO:0051917)4.84093582
10regulation of protein activation cascade (GO:2000257)4.83972885
11negative regulation of fibrinolysis (GO:0051918)4.79532248
12detection of other organism (GO:0098543)4.72345625
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69975701
14positive regulation by symbiont of host defense response (GO:0052509)4.68925097
15modulation by symbiont of host defense response (GO:0052031)4.68925097
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.68925097
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.68925097
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.68925097
19modulation by symbiont of host immune response (GO:0052553)4.68925097
20negative regulation of cell killing (GO:0031342)4.65660313
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.65660313
22detection of external biotic stimulus (GO:0098581)4.63934055
23regulation of complement activation (GO:0030449)4.62766547
24leukocyte migration involved in inflammatory response (GO:0002523)4.58336176
25detection of bacterium (GO:0016045)4.44054933
26regulation of triglyceride catabolic process (GO:0010896)4.28577327
27macrophage activation involved in immune response (GO:0002281)4.12654155
28cellular extravasation (GO:0045123)4.09858404
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.09716003
30L-phenylalanine catabolic process (GO:0006559)4.07689728
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.07689728
32detection of biotic stimulus (GO:0009595)4.01709512
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.94133530
34glyoxylate metabolic process (GO:0046487)3.89899506
35positive regulation of gamma-delta T cell activation (GO:0046645)3.87510400
36neutrophil activation involved in immune response (GO:0002283)3.84063743
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.79719548
38ethanol oxidation (GO:0006069)3.78767446
39antigen processing and presentation of endogenous antigen (GO:0019883)3.76546348
40negative regulation of protein activation cascade (GO:2000258)3.69604856
41alkaloid metabolic process (GO:0009820)3.67113896
42drug metabolic process (GO:0017144)3.64010749
43response to peptidoglycan (GO:0032494)3.63362290
44negative regulation of B cell mediated immunity (GO:0002713)3.63244726
45negative regulation of immunoglobulin mediated immune response (GO:0002890)3.63244726
46cellular glucuronidation (GO:0052695)3.61632889
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.59766767
48response to host immune response (GO:0052572)3.59766767
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.58599669
50microglial cell activation (GO:0001774)3.56265447
51regulation of interferon-beta biosynthetic process (GO:0045357)3.54730752
52regulation of humoral immune response (GO:0002920)3.53747928
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.53686770
54L-phenylalanine metabolic process (GO:0006558)3.53686770
55urea metabolic process (GO:0019627)3.53682579
56neutrophil activation (GO:0042119)3.49937125
57imidazole-containing compound metabolic process (GO:0052803)3.48929615
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48727940
59regulation of B cell receptor signaling pathway (GO:0050855)3.48628656
60fibrinolysis (GO:0042730)3.44826076
61killing of cells of other organism (GO:0031640)3.43401319
62disruption of cells of other organism (GO:0044364)3.43401319
63protein carboxylation (GO:0018214)3.38295124
64peptidyl-glutamic acid carboxylation (GO:0017187)3.38295124
65glucuronate metabolic process (GO:0019585)3.37909041
66uronic acid metabolic process (GO:0006063)3.37909041
67neutrophil mediated immunity (GO:0002446)3.34369894
68macrophage activation (GO:0042116)3.30719253
69response to interleukin-15 (GO:0070672)3.30673174
70blood coagulation, intrinsic pathway (GO:0007597)3.27992349
71negative regulation of complement activation (GO:0045916)3.27204810
72phospholipid efflux (GO:0033700)3.26558102
73oxidative demethylation (GO:0070989)3.25024307
74acute-phase response (GO:0006953)3.23942657
75protein activation cascade (GO:0072376)3.23262609
76response to host (GO:0075136)3.23176671
77response to host defenses (GO:0052200)3.23176671
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23176671
79bile acid and bile salt transport (GO:0015721)3.21642872
80respiratory burst (GO:0045730)3.20983265
81production of molecular mediator involved in inflammatory response (GO:0002532)3.20845298
82nitrogen cycle metabolic process (GO:0071941)3.17738059
83negative regulation of humoral immune response (GO:0002921)3.14467732
84bile acid biosynthetic process (GO:0006699)3.13732319
85complement activation (GO:0006956)3.13557763
86aromatic amino acid family catabolic process (GO:0009074)3.13102920
87negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.12895452
88positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.10410504
89leukocyte aggregation (GO:0070486)3.07507418
90regulation of gamma-delta T cell activation (GO:0046643)3.06450555
91positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.05817205
92cellular response to interleukin-15 (GO:0071350)3.03978158
93negative regulation of leukocyte mediated immunity (GO:0002704)3.03723396
94granulocyte activation (GO:0036230)3.03701503
95positive regulation of blood coagulation (GO:0030194)3.03662341
96positive regulation of hemostasis (GO:1900048)3.03662341
97negative regulation of cholesterol transport (GO:0032375)3.02713255
98negative regulation of sterol transport (GO:0032372)3.02713255
99phenylpropanoid metabolic process (GO:0009698)3.00429843
100opsonization (GO:0008228)3.00412808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.75026599
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.70676713
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.01159989
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.56212293
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.54495426
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.33422243
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.99319818
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97996021
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.96327003
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80282573
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.80191879
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77674701
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.73412136
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68124785
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.66293436
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.29981376
17RUNX_20019798_ChIP-Seq_JUKART_Human2.22025475
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21506508
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.16199450
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05036903
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04885019
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.03816485
23SPI1_23127762_ChIP-Seq_K562_Human1.99311977
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97123000
25* SPI1_23547873_ChIP-Seq_NB4_Human1.95052611
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92398484
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81967666
28VDR_24763502_ChIP-Seq_THP-1_Human1.79426692
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62338342
30SCL_19346495_ChIP-Seq_HPC-7_Human1.62152360
31VDR_24787735_ChIP-Seq_THP-1_Human1.60397027
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59058562
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58122328
34MYB_26560356_Chip-Seq_TH2_Human1.53152548
35GATA1_22025678_ChIP-Seq_K562_Human1.53030126
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51376939
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.48881227
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47746038
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44103816
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.44025586
41GATA3_26560356_Chip-Seq_TH2_Human1.43965470
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.43810963
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41260822
44MAF_26560356_Chip-Seq_TH1_Human1.40091610
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38153380
46MYB_26560356_Chip-Seq_TH1_Human1.37857628
47GATA3_27048872_Chip-Seq_THYMUS_Human1.36175348
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35598521
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32602364
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30177131
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29241075
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28282244
53VDR_21846776_ChIP-Seq_THP-1_Human1.27581907
54GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26185631
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24390759
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23104180
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22266383
58UTX_26944678_Chip-Seq_JUKART_Human1.21895699
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19758259
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17284334
61* FOXA2_19822575_ChIP-Seq_HepG2_Human1.16558950
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16376882
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12638628
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.09767079
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09086748
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08873691
67GATA1_19941826_ChIP-Seq_K562_Human1.07723998
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.04171765
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04113644
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03741907
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02840974
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01197177
73TCF7_22412390_ChIP-Seq_EML_Mouse1.00748144
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98102381
75PU_27001747_Chip-Seq_BMDM_Mouse0.97633421
76TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97373309
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97123684
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96752169
79* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95998169
80GATA2_19941826_ChIP-Seq_K562_Human0.95051574
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90660551
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90505111
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87541495
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86257961
85GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85633772
86MAF_26560356_Chip-Seq_TH2_Human0.84959954
87SPI1_20517297_ChIP-Seq_HL60_Human0.84881393
88BCL6_27268052_Chip-Seq_Bcells_Human0.82462476
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80332988
90SMRT_27268052_Chip-Seq_Bcells_Human0.79543195
91STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76986183
92BCOR_27268052_Chip-Seq_Bcells_Human0.76636786
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76590666
94CEBPB_22108803_ChIP-Seq_LS180_Human0.76505578
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.76325430
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75960042
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73812969
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73303579
99* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.71678438
100ER_23166858_ChIP-Seq_MCF-7_Human0.71096151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.40591490
2MP0003724_increased_susceptibility_to4.22837797
3MP0005085_abnormal_gallbladder_physiolo4.14122271
4MP0005365_abnormal_bile_salt3.37134953
5MP0003195_calcinosis3.34115649
6MP0003436_decreased_susceptibility_to3.31908226
7MP0005360_urolithiasis3.24941271
8MP0003252_abnormal_bile_duct3.16525871
9MP0003191_abnormal_cellular_cholesterol3.10602982
10MP0008875_abnormal_xenobiotic_pharmacok3.10393165
11MP0002138_abnormal_hepatobiliary_system3.04548796
12MP0003303_peritoneal_inflammation2.73789873
13MP0009785_altered_susceptibility_to2.60146146
14MP0002419_abnormal_innate_immunity2.52315104
15MP0001835_abnormal_antigen_presentation2.43106948
16MP0002132_abnormal_respiratory_system2.34922004
17MP0005025_abnormal_response_to2.26392392
18MP0000685_abnormal_immune_system2.14550268
19MP0001800_abnormal_humoral_immune2.07323248
20MP0010329_abnormal_lipoprotein_level1.88604657
21MP0005387_immune_system_phenotype1.86428767
22MP0001790_abnormal_immune_system1.86428767
23MP0005000_abnormal_immune_tolerance1.83726679
24MP0005464_abnormal_platelet_physiology1.83556143
25MP0009764_decreased_sensitivity_to1.81424007
26MP0002723_abnormal_immune_serum1.78072668
27MP0005451_abnormal_body_composition1.71786884
28MP0005671_abnormal_response_to1.71619699
29MP0006082_CNS_inflammation1.66049360
30MP0001533_abnormal_skeleton_physiology1.66044952
31MP0002420_abnormal_adaptive_immunity1.64722848
32MP0001666_abnormal_nutrient_absorption1.63269383
33MP0001819_abnormal_immune_cell1.63136328
34MP0002452_abnormal_antigen_presenting1.61639709
35MP0003656_abnormal_erythrocyte_physiolo1.56353852
36MP0008469_abnormal_protein_level1.55862379
37MP0003806_abnormal_nucleotide_metabolis1.52639610
38MP0004883_abnormal_blood_vessel1.50393075
39MP0003183_abnormal_peptide_metabolism1.49517726
40MP0008260_abnormal_autophagy1.48614958
41MP0000609_abnormal_liver_physiology1.47679058
42MP0001845_abnormal_inflammatory_respons1.44620131
43MP0002277_abnormal_respiratory_mucosa1.42110690
44MP0003300_gastrointestinal_ulcer1.40948526
45MP0002148_abnormal_hypersensitivity_rea1.36855200
46MP0003172_abnormal_lysosome_physiology1.33104444
47MP0002405_respiratory_system_inflammati1.32775314
48MP0010155_abnormal_intestine_physiology1.26947603
49MP0009840_abnormal_foam_cell1.26833716
50MP0003868_abnormal_feces_composition1.26227333
51MP0005164_abnormal_response_to1.26016639
52MP0002118_abnormal_lipid_homeostasis1.25261433
53MP0004381_abnormal_hair_follicle1.23761044
54MP0000716_abnormal_immune_system1.21202559
55MP0002398_abnormal_bone_marrow1.14064237
56MP0005319_abnormal_enzyme/_coenzyme1.13781783
57MP0005332_abnormal_amino_acid1.13185399
58MP0003866_abnormal_defecation1.12716316
59MP0000689_abnormal_spleen_morphology1.10422928
60MP0003828_pulmonary_edema1.09849029
61MP0009763_increased_sensitivity_to1.08154838
62MP0003690_abnormal_glial_cell1.07093992
63MP0003075_altered_response_to1.06973228
64MP0001851_eye_inflammation1.05872935
65MP0002722_abnormal_immune_system1.02026473
66MP0003763_abnormal_thymus_physiology0.99626226
67MP0005397_hematopoietic_system_phenotyp0.98309966
68MP0001545_abnormal_hematopoietic_system0.98309966
69MP0000465_gastrointestinal_hemorrhage0.93511955
70MP0002876_abnormal_thyroid_physiology0.92603388
71MP0005376_homeostasis/metabolism_phenot0.92487155
72MP0002396_abnormal_hematopoietic_system0.92249108
73MP0002429_abnormal_blood_cell0.90590751
74MP0001764_abnormal_homeostasis0.90582614
75MP0000858_altered_metastatic_potential0.89960408
76MP0004947_skin_inflammation0.87684058
77MP0009333_abnormal_splenocyte_physiolog0.86976053
78MP0005166_decreased_susceptibility_to0.86228076
79MP0000604_amyloidosis0.85596227
80MP0004019_abnormal_vitamin_homeostasis0.85529586
81MP0003878_abnormal_ear_physiology0.85385832
82MP0005377_hearing/vestibular/ear_phenot0.85385832
83MP0001986_abnormal_taste_sensitivity0.85120893
84MP0005584_abnormal_enzyme/coenzyme_acti0.81471400
85MP0004130_abnormal_muscle_cell0.80916133
86MP0009642_abnormal_blood_homeostasis0.79834947
87MP0000569_abnormal_digit_pigmentation0.77819776
88MP0003045_fibrosis0.76861584
89MP0000598_abnormal_liver_morphology0.76790963
90MP0009765_abnormal_xenobiotic_induced0.76560047
91MP0002928_abnormal_bile_duct0.75637603
92MP0003011_delayed_dark_adaptation0.75012430
93MP0005535_abnormal_body_temperature0.73508879
94MP0009278_abnormal_bone_marrow0.72605145
95MP0008874_decreased_physiological_sensi0.72105724
96MP0001663_abnormal_digestive_system0.67731459
97MP0000703_abnormal_thymus_morphology0.67227650
98MP0005310_abnormal_salivary_gland0.67210184
99MP0009643_abnormal_urine_homeostasis0.66981246
100MP0000249_abnormal_blood_vessel0.66113358

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)6.48380011
2Deep venous thrombosis (HP:0002625)5.85268934
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.74097592
4Orchitis (HP:0100796)5.22807447
5Eczematoid dermatitis (HP:0000976)5.14107519
6Myositis (HP:0100614)5.13992833
7Complement deficiency (HP:0004431)5.06960077
8Optic neuritis (HP:0100653)5.05693728
9Retrobulbar optic neuritis (HP:0100654)5.05693728
10Prolonged partial thromboplastin time (HP:0003645)5.03790632
11Hypochromic microcytic anemia (HP:0004840)4.94366193
12Recurrent abscess formation (HP:0002722)4.67325545
13Hypobetalipoproteinemia (HP:0003563)4.53266676
14Joint hemorrhage (HP:0005261)4.42664982
15Abnormality of complement system (HP:0005339)4.35630857
16Recurrent bacterial skin infections (HP:0005406)4.28903945
17Gingival bleeding (HP:0000225)4.22807355
18Abnormality of aromatic amino acid family metabolism (HP:0004338)4.22198339
19Systemic lupus erythematosus (HP:0002725)4.15753807
20Gastrointestinal infarctions (HP:0005244)3.99387515
21Hypochromic anemia (HP:0001931)3.93144215
22Conjugated hyperbilirubinemia (HP:0002908)3.91803383
23Keratoconjunctivitis sicca (HP:0001097)3.76617218
24Stomatitis (HP:0010280)3.75308256
25Hyperlipoproteinemia (HP:0010980)3.70629128
26Abnormality of macrophages (HP:0004311)3.69982660
27Abnormality of the common coagulation pathway (HP:0010990)3.61308624
28Keratoconjunctivitis (HP:0001096)3.54985302
29Pulmonary embolism (HP:0002204)3.45749109
30Elevated erythrocyte sedimentation rate (HP:0003565)3.29024010
31Meningitis (HP:0001287)3.28130941
32Glomerulonephritis (HP:0000099)3.23846868
33Obstructive lung disease (HP:0006536)3.20781161
34Chronic obstructive pulmonary disease (HP:0006510)3.20781161
35Gingivitis (HP:0000230)3.15405309
36Encephalitis (HP:0002383)3.12852240
37Anorexia (HP:0002039)3.09513035
38Abnormality of pyrimidine metabolism (HP:0004353)3.07474100
39Gangrene (HP:0100758)3.04200112
40Recurrent skin infections (HP:0001581)3.04056060
41Peritonitis (HP:0002586)3.01914013
42Recurrent fungal infections (HP:0002841)3.01611634
43Epistaxis (HP:0000421)2.99592136
44Spontaneous hematomas (HP:0007420)2.95509561
45Thrombophlebitis (HP:0004418)2.95247573
46Spontaneous abortion (HP:0005268)2.93044789
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.87650926
48Prolonged bleeding time (HP:0003010)2.87306296
49Vasculitis (HP:0002633)2.84666784
50Arterial thrombosis (HP:0004420)2.81729480
51Amyloidosis (HP:0011034)2.81411421
52Mediastinal lymphadenopathy (HP:0100721)2.78854970
53Microcytic anemia (HP:0001935)2.76536503
54Xanthomatosis (HP:0000991)2.75666314
55Hemoptysis (HP:0002105)2.73938007
56Urticaria (HP:0001025)2.68690695
57Episodic fever (HP:0001954)2.54913616
58Purpura (HP:0000979)2.53509336
59Chronic mucocutaneous candidiasis (HP:0002728)2.50250936
60Recurrent cutaneous fungal infections (HP:0011370)2.50250936
61Osteomalacia (HP:0002749)2.49398307
62Pulmonary infiltrates (HP:0002113)2.47290410
63Abnormality of iron homeostasis (HP:0011031)2.46245912
64Increased IgE level (HP:0003212)2.45203356
65Joint swelling (HP:0001386)2.41295082
66Abnormal platelet volume (HP:0011876)2.40491151
67Nephritis (HP:0000123)2.39992597
68Menorrhagia (HP:0000132)2.35528001
69Hypolipoproteinemia (HP:0010981)2.33324747
70Hemorrhage of the eye (HP:0011885)2.32157598
71Chest pain (HP:0100749)2.31136533
72Intrahepatic cholestasis (HP:0001406)2.28571772
73Abnormality of transition element cation homeostasis (HP:0011030)2.26116277
74Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.24579941
75Acne (HP:0001061)2.21022194
76Increased serum ferritin (HP:0003281)2.20352703
77Abnormality of the pleura (HP:0002103)2.15422455
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.11684722
79Hepatocellular carcinoma (HP:0001402)2.10977780
80Poikilocytosis (HP:0004447)2.09672766
81Arthropathy (HP:0003040)2.08637616
82Leukocytosis (HP:0001974)2.07280401
83Polycythemia (HP:0001901)2.05688142
84Toxemia of pregnancy (HP:0100603)2.04773242
85Abnormality of T cell number (HP:0011839)2.00651926
86Fat malabsorption (HP:0002630)2.00083876
87Acute hepatic failure (HP:0006554)1.98181361
88Rickets (HP:0002748)1.97838078
89T lymphocytopenia (HP:0005403)1.93417309
90Mitral stenosis (HP:0001718)1.89499409
91Cellulitis (HP:0100658)1.88656967
92Abnormality of glutamine family amino acid metabolism (HP:0010902)1.86335771
93Keratitis (HP:0000491)1.86066455
94Abnormality of the endocardium (HP:0004306)1.85347734
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84404136
96Skin rash (HP:0000988)1.83646225
97Abnormality of the peritoneum (HP:0002585)1.83047578
98Pustule (HP:0200039)1.82419059
99Periodontitis (HP:0000704)1.81692857
100Increased mean platelet volume (HP:0011877)1.81085956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.17709228
2IRAK43.46734494
3MAP2K33.12981358
4ERN13.09598829
5BLK2.99445741
6TYK22.83504639
7MAP4K12.82463626
8EPHB12.52266278
9GRK62.44282815
10CSK2.39362586
11TNK22.32220654
12FES2.07429435
13MAP3K31.94018149
14ZAP701.88313969
15TXK1.87190481
16TAOK11.80766439
17TAOK31.79604410
18IRAK11.70090263
19JAK21.60660699
20HCK1.59620606
21MAP3K21.57287833
22SYK1.52596436
23MAP3K111.50862839
24KSR21.50325548
25FGR1.49300914
26PRPF4B1.47318755
27BTK1.46588577
28YES11.46249235
29PIK3CG1.43917045
30EPHA31.42536824
31JAK31.41176693
32IKBKE1.41061062
33MAP3K11.38168700
34MAP2K41.31594813
35LYN1.27793993
36JAK11.26982491
37FRK1.22492378
38MAP3K61.14854424
39FGFR31.12234242
40FGFR41.11739355
41MAP3K141.10816242
42TBK11.05248990
43DAPK21.03557698
44IRAK21.01514050
45LCK0.98476493
46SIK30.93665109
47PDK10.93339358
48CSF1R0.91934915
49PTK60.91805391
50MAP2K60.90846028
51KIT0.89974966
52MARK30.88178164
53NLK0.87919168
54MATK0.87215671
55SIK20.86416750
56ITK0.85361723
57PDPK10.84026430
58PTK2B0.83906538
59MARK20.80039953
60STK110.76388499
61TEC0.76217415
62MAP3K50.75461637
63DYRK1B0.74519147
64SGK20.71461336
65SGK30.71215390
66STK380.69503324
67MAP3K70.69143166
68ACVR1B0.68614639
69CAMKK20.67167745
70BMPR20.66849996
71PRKD20.65787177
72KSR10.63708218
73WNK10.62545522
74PRKAA20.62505157
75MAP3K130.62348743
76PRKCZ0.62324960
77LRRK20.61884800
78RET0.61747334
79TGFBR20.60787433
80FYN0.60078600
81PRKCQ0.60069034
82IKBKB0.60060458
83RAF10.58349617
84STK100.54746240
85OXSR10.51837765
86TAOK20.48213202
87MAPK120.47963663
88CDK190.46683060
89HIPK20.43507262
90SIK10.40945709
91SGK2230.39814559
92SGK4940.39814559
93PAK30.39656906
94TRIB30.38808166
95PRKG20.37945506
96PIM10.35972254
97PRKACG0.35330242
98CAMKK10.35266357
99CAMK40.34164032
100ERBB20.33285353

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.08479941
2Complement and coagulation cascades_Homo sapiens_hsa046103.78270047
3Staphylococcus aureus infection_Homo sapiens_hsa051503.26136159
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.13721052
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88023518
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.84152232
7Retinol metabolism_Homo sapiens_hsa008302.84102800
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71534966
9Chemical carcinogenesis_Homo sapiens_hsa052042.49911854
10Drug metabolism - other enzymes_Homo sapiens_hsa009832.44653534
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.28510182
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.09909564
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05935359
14Fatty acid degradation_Homo sapiens_hsa000711.86922824
15Phenylalanine metabolism_Homo sapiens_hsa003601.81674377
16Linoleic acid metabolism_Homo sapiens_hsa005911.79141489
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71322096
18Histidine metabolism_Homo sapiens_hsa003401.70293132
19Leishmaniasis_Homo sapiens_hsa051401.69670405
20Osteoclast differentiation_Homo sapiens_hsa043801.64645688
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63254932
22Tyrosine metabolism_Homo sapiens_hsa003501.56843920
23Arginine biosynthesis_Homo sapiens_hsa002201.55846248
24Starch and sucrose metabolism_Homo sapiens_hsa005001.48525342
25Bile secretion_Homo sapiens_hsa049761.47833131
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47372740
27Butanoate metabolism_Homo sapiens_hsa006501.35482102
28Tryptophan metabolism_Homo sapiens_hsa003801.28565709
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22559299
30PPAR signaling pathway_Homo sapiens_hsa033201.17662659
31Tuberculosis_Homo sapiens_hsa051521.15010512
32* Arachidonic acid metabolism_Homo sapiens_hsa005901.10285713
33Malaria_Homo sapiens_hsa051441.07419134
34African trypanosomiasis_Homo sapiens_hsa051431.02477830
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01159413
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00597613
37B cell receptor signaling pathway_Homo sapiens_hsa046620.99817919
38ABC transporters_Homo sapiens_hsa020100.98171815
39NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92873719
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92710639
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91179206
42Pertussis_Homo sapiens_hsa051330.89283807
43Peroxisome_Homo sapiens_hsa041460.88012098
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.86707609
45Graft-versus-host disease_Homo sapiens_hsa053320.80407345
46Measles_Homo sapiens_hsa051620.80382225
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80240038
48Chemokine signaling pathway_Homo sapiens_hsa040620.79579916
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.76136268
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73509367
51beta-Alanine metabolism_Homo sapiens_hsa004100.72814915
52Allograft rejection_Homo sapiens_hsa053300.72528651
53Legionellosis_Homo sapiens_hsa051340.72070736
54Hematopoietic cell lineage_Homo sapiens_hsa046400.68213806
55Primary immunodeficiency_Homo sapiens_hsa053400.67619092
56Autoimmune thyroid disease_Homo sapiens_hsa053200.65849428
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64985863
58Insulin resistance_Homo sapiens_hsa049310.63022400
59Fat digestion and absorption_Homo sapiens_hsa049750.62456894
60Acute myeloid leukemia_Homo sapiens_hsa052210.61531724
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.60325423
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59661309
63T cell receptor signaling pathway_Homo sapiens_hsa046600.59350639
64Prion diseases_Homo sapiens_hsa050200.58506010
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.57500484
66Phagosome_Homo sapiens_hsa041450.57411137
67Influenza A_Homo sapiens_hsa051640.56758071
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56015893
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.55037504
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55020262
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54569911
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53706902
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52521387
74Platelet activation_Homo sapiens_hsa046110.52151533
75Hepatitis C_Homo sapiens_hsa051600.51403001
76Toxoplasmosis_Homo sapiens_hsa051450.48681142
77Type I diabetes mellitus_Homo sapiens_hsa049400.46360928
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45519585
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.45116756
80TNF signaling pathway_Homo sapiens_hsa046680.44443783
81Glycerolipid metabolism_Homo sapiens_hsa005610.43950248
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.43142388
83Non-small cell lung cancer_Homo sapiens_hsa052230.39905859
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37401644
85Herpes simplex infection_Homo sapiens_hsa051680.32670043
86FoxO signaling pathway_Homo sapiens_hsa040680.31835487
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31061341
88Antigen processing and presentation_Homo sapiens_hsa046120.31052797
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29465981
90Prolactin signaling pathway_Homo sapiens_hsa049170.29399704
91Amoebiasis_Homo sapiens_hsa051460.28932449
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25797062
93Hepatitis B_Homo sapiens_hsa051610.24992459
94Regulation of autophagy_Homo sapiens_hsa041400.23419595
95Dorso-ventral axis formation_Homo sapiens_hsa043200.22569684
96Fatty acid metabolism_Homo sapiens_hsa012120.20941002
97Type II diabetes mellitus_Homo sapiens_hsa049300.19860755
98Vitamin digestion and absorption_Homo sapiens_hsa049770.19641181
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18363548
100Other glycan degradation_Homo sapiens_hsa005110.16945637

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