CYP4F30P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus (GO:0016048)9.18007012
2import into cell (GO:0098657)9.07541806
3retinal metabolic process (GO:0042574)8.07316253
4protein homotrimerization (GO:0070207)7.48756952
5adaptation of signaling pathway (GO:0023058)7.33683089
6biotin metabolic process (GO:0006768)7.29229121
7branching involved in prostate gland morphogenesis (GO:0060442)7.27809820
8retina homeostasis (GO:0001895)6.89788163
9positive regulation of glycolytic process (GO:0045821)6.64679771
10prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.12627116
11artery development (GO:0060840)5.61681247
12polyamine biosynthetic process (GO:0006596)5.33811733
13negative regulation of protein localization to cell surface (GO:2000009)5.19951623
14lung lobe morphogenesis (GO:0060463)5.15797651
15negative regulation of sodium ion transport (GO:0010766)4.91994801
16copper ion transport (GO:0006825)4.91698264
17retinol metabolic process (GO:0042572)4.90120186
18negative regulation of systemic arterial blood pressure (GO:0003085)4.82564246
19regulation of transcription from RNA polymerase III promoter (GO:0006359)4.76321091
20response to cold (GO:0009409)4.63698444
21negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.59331918
22establishment of protein localization to Golgi (GO:0072600)4.46265290
23prostate gland epithelium morphogenesis (GO:0060740)4.30115352
24UDP-N-acetylglucosamine metabolic process (GO:0006047)4.28504044
25negative regulation of potassium ion transmembrane transport (GO:1901380)4.17209114
26lung vasculature development (GO:0060426)4.17182527
27positive regulation of glycogen biosynthetic process (GO:0045725)4.06513269
28negative regulation of fatty acid transport (GO:2000192)4.03289871
29regulation of fatty acid beta-oxidation (GO:0031998)4.00579802
30regulation of establishment or maintenance of cell polarity (GO:0032878)4.00100633
31misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.99857192
32exocrine pancreas development (GO:0031017)3.99161706
33cilium or flagellum-dependent cell motility (GO:0001539)3.97902480
34positive regulation of steroid hormone secretion (GO:2000833)3.92910855
35zinc ion homeostasis (GO:0055069)3.92099368
36positive regulation of filopodium assembly (GO:0051491)3.90319717
37regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.82972456
38branched-chain amino acid catabolic process (GO:0009083)3.81780563
39protein targeting to Golgi (GO:0000042)3.80727673
40diterpenoid biosynthetic process (GO:0016102)3.80289607
41cellular biogenic amine biosynthetic process (GO:0042401)3.79130719
42mammary gland development (GO:0030879)3.78538323
43retrograde transport, vesicle recycling within Golgi (GO:0000301)3.78048906
44zinc ion transmembrane transport (GO:0071577)3.73000386
45endothelial cell chemotaxis (GO:0035767)3.69115542
46positive regulation of glycogen metabolic process (GO:0070875)3.65565829
47regulation of receptor binding (GO:1900120)3.62265668
48amine biosynthetic process (GO:0009309)3.61319218
49Golgi to plasma membrane transport (GO:0006893)3.59473263
50protein trimerization (GO:0070206)3.57923602
51regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.55532062
52short-chain fatty acid metabolic process (GO:0046459)3.55131228
53peptidyl-lysine dimethylation (GO:0018027)3.52769713
54positive regulation of fatty acid beta-oxidation (GO:0032000)3.51754048
55lipid translocation (GO:0034204)3.51294338
56phospholipid translocation (GO:0045332)3.51294338
57polyamine metabolic process (GO:0006595)3.47471057
58regulation of glycolytic process (GO:0006110)3.43386743
59coenzyme A metabolic process (GO:0015936)3.38347557
60primary alcohol metabolic process (GO:0034308)3.35871162
61branched-chain amino acid metabolic process (GO:0009081)3.31865608
62protein localization to Golgi apparatus (GO:0034067)3.25589830
63regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.25225820
64opsonization (GO:0008228)3.21553771
65benzene-containing compound metabolic process (GO:0042537)3.21483375
66pharyngeal system development (GO:0060037)3.17661805
67regulation of fatty acid oxidation (GO:0046320)3.16185718
68positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.12710994
69insulin-like growth factor receptor signaling pathway (GO:0048009)3.11663900
70adenosine metabolic process (GO:0046085)3.11156527
71ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.08879477
72mitotic cell cycle arrest (GO:0071850)3.08838692
73monoubiquitinated protein deubiquitination (GO:0035520)3.06675323
74epithelial cell maturation (GO:0002070)3.05304886
75lung epithelial cell differentiation (GO:0060487)3.02302120
76righting reflex (GO:0060013)2.99758365
77carnitine transmembrane transport (GO:1902603)2.96715261
78regulation of clathrin-mediated endocytosis (GO:2000369)2.93172582
79protein targeting to vacuole (GO:0006623)2.91445403
80protein targeting to lysosome (GO:0006622)2.91445403
81establishment of protein localization to vacuole (GO:0072666)2.91445403
82regulation of tight junction assembly (GO:2000810)2.90664296
83anterior/posterior axis specification, embryo (GO:0008595)2.90608672
84lung cell differentiation (GO:0060479)2.90038988
85positive regulation of fatty acid oxidation (GO:0046321)2.88937116
86retina vasculature morphogenesis in camera-type eye (GO:0061299)2.88684634
87regulation of establishment of cell polarity (GO:2000114)2.86499658
88detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.84985625
89methionine metabolic process (GO:0006555)2.83615156
90lung secretory cell differentiation (GO:0061140)2.82015470
91protein import into peroxisome matrix (GO:0016558)2.80157699
92endocrine hormone secretion (GO:0060986)2.76986695
93prostate gland growth (GO:0060736)2.74568244
94carnitine transport (GO:0015879)2.74319645
95amino-acid betaine transport (GO:0015838)2.74319645
96fatty acid elongation (GO:0030497)2.74031570
97terpenoid biosynthetic process (GO:0016114)2.73778777
98carnitine shuttle (GO:0006853)2.72214378
99regulation of steroid hormone secretion (GO:2000831)2.72174980
100iron ion import (GO:0097286)12.7602046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse8.79258698
2PIAS1_25552417_ChIP-Seq_VCAP_Human4.37947295
3AR_21909140_ChIP-Seq_LNCAP_Human4.34012137
4AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human3.24234910
5AR_21915096_ChIP-Seq_LNCaP-1F5_Human3.22833868
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.21877426
7FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human3.20002918
8IGF1R_20145208_ChIP-Seq_DFB_Human3.18984478
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.10047362
10AR_21572438_ChIP-Seq_LNCaP_Human2.93832333
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.38401119
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31984253
13ZNF274_21170338_ChIP-Seq_K562_Hela2.29883736
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15157037
15VDR_22108803_ChIP-Seq_LS180_Human2.11760199
16FOXA1_25552417_ChIP-Seq_VCAP_Human2.06186566
17ZNF217_24962896_ChIP-Seq_MCF-7_Human2.03268523
18FOXM1_26456572_ChIP-Seq_MCF-7_Human1.94426792
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86460608
20AHR_22903824_ChIP-Seq_MCF-7_Human1.84642441
21EZH2_22144423_ChIP-Seq_EOC_Human1.74528030
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69021964
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68045988
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66783462
25ARNT_22903824_ChIP-Seq_MCF-7_Human1.66229040
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.65983632
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60218115
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60218115
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.59659609
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56822234
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.55603136
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55355299
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54434683
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52604979
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52604979
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49253054
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46793390
38ER_23166858_ChIP-Seq_MCF-7_Human1.41172339
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40857146
40FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.40183030
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37931198
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37479660
43PRDM14_20953172_ChIP-Seq_ESCs_Human1.35663359
44CHD1_26751641_Chip-Seq_LNCaP_Human1.30694443
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.30606937
46EWS_26573619_Chip-Seq_HEK293_Human1.27437310
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27069145
48AR_25329375_ChIP-Seq_VCAP_Human1.26820500
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.25821416
50P300_19829295_ChIP-Seq_ESCs_Human1.25204424
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23988962
52TCF4_23295773_ChIP-Seq_U87_Human1.23036020
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18370563
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.14932280
55GATA3_24758297_ChIP-Seq_MCF-7_Human1.14587314
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14133762
57PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13988750
58GF1B_26923725_Chip-Seq_HPCs_Mouse1.13920778
59STAT3_23295773_ChIP-Seq_U87_Human1.13465355
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13385252
61IRF1_19129219_ChIP-ChIP_H3396_Human1.11174799
62RUNX2_22187159_ChIP-Seq_PCA_Human1.09959996
63OCT1_27270436_Chip-Seq_PROSTATE_Human1.09919730
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07931185
65CBP_20019798_ChIP-Seq_JUKART_Human1.07931185
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.07779838
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07703851
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06669508
69SMAD4_21799915_ChIP-Seq_A2780_Human1.05867735
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05398082
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05094339
72TCF4_22108803_ChIP-Seq_LS180_Human1.01496701
73RXR_22108803_ChIP-Seq_LS180_Human1.00165884
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99259196
75CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98591882
76KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96310752
77SMAD3_21741376_ChIP-Seq_EPCs_Human0.94890199
78DROSHA_22980978_ChIP-Seq_HELA_Human0.94420167
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93718849
80AR_19668381_ChIP-Seq_PC3_Human0.92175462
81EP300_21415370_ChIP-Seq_HL-1_Mouse0.91948151
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.91830565
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91677631
84YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91085514
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90879158
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90541718
87SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90140349
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89862366
89CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87805614
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.87127810
91CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85338899
92TAL1_26923725_Chip-Seq_HPCs_Mouse0.84780340
93GBX2_23144817_ChIP-Seq_PC3_Human0.83557497
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83557236
95GATA4_25053715_ChIP-Seq_YYC3_Human0.81380290
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80624047
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79515810
98CDX2_22108803_ChIP-Seq_LS180_Human0.78893523
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.78673195
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78277874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation7.36666886
2MP0005167_abnormal_blood-brain_barrier6.79111674
3MP0002736_abnormal_nociception_after6.68436888
4MP0004043_abnormal_pH_regulation6.47029441
5MP0001968_abnormal_touch/_nociception4.47427120
6MP0002735_abnormal_chemical_nociception4.10704124
7MP0002234_abnormal_pharynx_morphology3.36563085
8MP0002733_abnormal_thermal_nociception2.49116319
9MP0005085_abnormal_gallbladder_physiolo2.24422660
10MP0004858_abnormal_nervous_system2.22724085
11MP0005310_abnormal_salivary_gland2.12174187
12MP0002638_abnormal_pupillary_reflex2.00849231
13MP0002166_altered_tumor_susceptibility1.93733688
14MP0005083_abnormal_biliary_tract1.91581927
15MP0001765_abnormal_ion_homeostasis1.65667916
16MP0003718_maternal_effect1.63389301
17MP0001664_abnormal_digestion1.62671250
18MP0005647_abnormal_sex_gland1.59216932
19MP0002009_preneoplasia1.58937922
20MP0001188_hyperpigmentation1.50180101
21MP0003315_abnormal_perineum_morphology1.46876947
22MP0002822_catalepsy1.43037900
23MP0005551_abnormal_eye_electrophysiolog1.42705332
24MP0005253_abnormal_eye_physiology1.37278963
25MP0001970_abnormal_pain_threshold1.36821974
26MP0000230_abnormal_systemic_arterial1.35021284
27MP0002006_tumorigenesis1.29205908
28MP0002090_abnormal_vision1.27978491
29MP0005248_abnormal_Harderian_gland1.19094807
30MP0005636_abnormal_mineral_homeostasis1.17409751
31MP0000613_abnormal_salivary_gland1.13379031
32MP0005076_abnormal_cell_differentiation1.13367832
33MP0002160_abnormal_reproductive_system1.12622066
34MP0005365_abnormal_bile_salt1.11292106
35MP0008057_abnormal_DNA_replication1.10460812
36MP0001756_abnormal_urination1.09655829
37MP0003633_abnormal_nervous_system1.08261260
38MP0002928_abnormal_bile_duct1.05961438
39MP0005187_abnormal_penis_morphology1.04002209
40MP0009703_decreased_birth_body1.03693050
41MP0003890_abnormal_embryonic-extraembry1.02886637
42MP0005646_abnormal_pituitary_gland0.98091811
43MP0005220_abnormal_exocrine_pancreas0.96720590
44MP0003879_abnormal_hair_cell0.95544134
45MP0001919_abnormal_reproductive_system0.92853488
46MP0000537_abnormal_urethra_morphology0.91989915
47MP0002909_abnormal_adrenal_gland0.89163664
48MP0003866_abnormal_defecation0.88979109
49MP0000516_abnormal_urinary_system0.88799862
50MP0005367_renal/urinary_system_phenotyp0.88799862
51MP0003045_fibrosis0.88472207
52MP0006072_abnormal_retinal_apoptosis0.83915005
53MP0005410_abnormal_fertilization0.82625263
54MP0008961_abnormal_basal_metabolism0.82368041
55MP0000627_abnormal_mammary_gland0.80764498
56MP0000538_abnormal_urinary_bladder0.79494548
57MP0002075_abnormal_coat/hair_pigmentati0.78926976
58MP0004264_abnormal_extraembryonic_tissu0.77924180
59MP0003868_abnormal_feces_composition0.77598577
60MP0001879_abnormal_lymphatic_vessel0.77145600
61MP0002136_abnormal_kidney_physiology0.76953993
62MP0001502_abnormal_circadian_rhythm0.74162077
63MP0005389_reproductive_system_phenotype0.74131404
64MP0004742_abnormal_vestibular_system0.73360209
65MP0001501_abnormal_sleep_pattern0.71802938
66MP0010307_abnormal_tumor_latency0.70661647
67MP0000432_abnormal_head_morphology0.70653312
68MP0003698_abnormal_male_reproductive0.69712441
69MP0003936_abnormal_reproductive_system0.68922843
70MP0003631_nervous_system_phenotype0.68204048
71MP0005084_abnormal_gallbladder_morpholo0.67581442
72MP0005395_other_phenotype0.66237830
73MP0002067_abnormal_sensory_capabilities0.66178001
74MP0001666_abnormal_nutrient_absorption0.65915611
75MP0000631_abnormal_neuroendocrine_gland0.65452717
76MP0003252_abnormal_bile_duct0.64832114
77MP0001186_pigmentation_phenotype0.63794625
78MP0003953_abnormal_hormone_level0.61042655
79MP0004085_abnormal_heartbeat0.61030122
80MP0001542_abnormal_bone_strength0.59844017
81MP0010771_integument_phenotype0.54448503
82MP0005595_abnormal_vascular_smooth0.53437644
83MP0003136_yellow_coat_color0.53270921
84MP0005448_abnormal_energy_balance0.52446823
85MP0002557_abnormal_social/conspecific_i0.51724887
86MP0002108_abnormal_muscle_morphology0.51679433
87MP0002118_abnormal_lipid_homeostasis0.51003695
88MP0004019_abnormal_vitamin_homeostasis0.50816220
89MP0000477_abnormal_intestine_morphology0.50563724
90MP0005670_abnormal_white_adipose0.50335386
91MP0001929_abnormal_gametogenesis0.49845652
92MP0010386_abnormal_urinary_bladder0.48200178
93MP0005360_urolithiasis0.47238226
94MP0002078_abnormal_glucose_homeostasis0.47026604
95MP0004883_abnormal_blood_vessel0.46114333
96MP0002876_abnormal_thyroid_physiology0.45388086
97MP0002116_abnormal_craniofacial_bone0.44424629
98MP0004134_abnormal_chest_morphology0.44145889
99MP0001731_abnormal_postnatal_growth0.43569035
100MP0004924_abnormal_behavior0.43121603

Predicted human phenotypes

RankGene SetZ-score
1Renal tubular acidosis (HP:0001947)5.03445009
2Broad face (HP:0000283)4.81675592
3Fibular aplasia (HP:0002990)4.60807873
4Hyperglycinuria (HP:0003108)4.38283569
5Abnormality of the nasal septum (HP:0000419)4.22289091
6Abnormality of the axillary hair (HP:0100134)3.98144902
7Abnormality of secondary sexual hair (HP:0009888)3.98144902
8Abnormality of the proximal phalanges of the hand (HP:0009834)3.94981123
9Long toe (HP:0010511)3.85237374
10Decreased circulating renin level (HP:0003351)3.67037160
11Broad-based gait (HP:0002136)3.56534330
12Genetic anticipation (HP:0003743)3.46884696
13Severe Myopia (HP:0011003)3.25125336
14Sparse lateral eyebrow (HP:0005338)3.21141578
15Progressive cerebellar ataxia (HP:0002073)3.17984777
16Hyperventilation (HP:0002883)3.11474496
17Ketoacidosis (HP:0001993)3.09916540
18Abnormality of glycine metabolism (HP:0010895)3.08505318
19Abnormality of serine family amino acid metabolism (HP:0010894)3.08505318
20Abnormality of the fingertips (HP:0001211)2.94607171
21Narrow palate (HP:0000189)2.89786337
22Generalized hypopigmentation of hair (HP:0011358)2.88102165
23Hypoplastic nipples (HP:0002557)2.82420358
24Gaze-evoked nystagmus (HP:0000640)2.80564192
25Buphthalmos (HP:0000557)2.79519619
26Clumsiness (HP:0002312)2.77067550
27Amelogenesis imperfecta (HP:0000705)2.68833230
28Azoospermia (HP:0000027)2.66446049
29Flat acetabular roof (HP:0003180)2.63455651
30Wide intermamillary distance (HP:0006610)2.60238939
31Obstructive sleep apnea (HP:0002870)2.57305969
32Hypoplasia of the uterus (HP:0000013)2.57017959
33Protruding tongue (HP:0010808)2.55732293
34Pancreatic cysts (HP:0001737)2.55153187
35Aplasia of the musculature (HP:0100854)2.54327840
36Aplasia/Hypoplasia of the ulna (HP:0006495)2.52790685
37Laryngomalacia (HP:0001601)2.47661197
38Hypoplasia of the ulna (HP:0003022)2.44261820
39Renal tubular dysfunction (HP:0000124)2.43495430
40Aplasia/Hypoplasia of the fibula (HP:0006492)2.43039129
41Overgrowth (HP:0001548)2.42451451
42Ketosis (HP:0001946)2.41037585
43Short humerus (HP:0005792)2.38888792
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.36933836
45Anal stenosis (HP:0002025)2.36532111
46Breast hypoplasia (HP:0003187)2.34709463
47Bronchomalacia (HP:0002780)2.33866672
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.33572861
49Seborrheic dermatitis (HP:0001051)2.31267423
50Pancreatic fibrosis (HP:0100732)2.25910761
51Abnormal tarsal ossification (HP:0008369)2.24407570
52Chronic hepatic failure (HP:0100626)2.23916920
53Nasal speech (HP:0001611)2.23624172
54Neoplasm of the heart (HP:0100544)2.22765058
55Papilledema (HP:0001085)2.17838852
56Germ cell neoplasia (HP:0100728)2.16758206
57Advanced eruption of teeth (HP:0006288)2.15145774
58Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.14842612
59Gonadotropin excess (HP:0000837)2.14104488
60Shallow orbits (HP:0000586)2.11340513
61Dysmetric saccades (HP:0000641)2.10012256
62Aplasia/hypoplasia of the humerus (HP:0006507)2.09561984
63Rectal prolapse (HP:0002035)2.07880136
64Decreased muscle mass (HP:0003199)2.07122177
65Short phalanx of the thumb (HP:0009660)2.06065625
66Abnormal hand bone ossification (HP:0010660)2.05895056
67Acute myeloid leukemia (HP:0004808)2.05848991
68Abnormal spermatogenesis (HP:0008669)2.04401128
69Fair hair (HP:0002286)2.03424159
70Intrahepatic cholestasis (HP:0001406)2.01378397
71Absent radius (HP:0003974)1.99481148
72Synostosis of carpal bones (HP:0005048)1.97768671
73Hypothermia (HP:0002045)1.96100176
74Abnormality of the renal medulla (HP:0100957)1.95016557
75Aplasia/hypoplasia of the femur (HP:0005613)1.94670762
76Abnormality of the ischium (HP:0003174)1.93051579
77Hypoplasia of the odontoid process (HP:0003311)1.92607937
78Cystic liver disease (HP:0006706)1.91861507
79Nephronophthisis (HP:0000090)1.91812305
80Aplasia involving forearm bones (HP:0009822)1.89698783
81Absent forearm bone (HP:0003953)1.89698783
82Aplasia involving bones of the upper limbs (HP:0009823)1.89550572
83Aplasia of the phalanges of the hand (HP:0009802)1.89550572
84Aplasia involving bones of the extremities (HP:0009825)1.89550572
85Abnormal foot bone ossification (HP:0010675)1.88481455
86Short 1st metacarpal (HP:0010034)1.88206536
87Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.88206536
88Abnormality of the right ventricle (HP:0001707)1.86424557
89Aplasia/hypoplasia of the uterus (HP:0008684)1.85347806
90Lip pit (HP:0100267)1.83533253
91Congenital glaucoma (HP:0001087)1.81838016
92Depressed nasal tip (HP:0000437)1.80460742
93Abnormality of the fibula (HP:0002991)1.80154112
94Mixed hearing impairment (HP:0000410)1.79542050
95Tracheomalacia (HP:0002779)1.77450473
96True hermaphroditism (HP:0010459)1.76919222
97Adactyly (HP:0009776)1.76856142
98Abnormal hair whorl (HP:0010721)1.76392443
99Shawl scrotum (HP:0000049)1.73479119
100Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73337999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT39.97567615
2CAMK1D4.02594180
3FRK3.42534284
4EEF2K3.04588500
5SGK23.04485441
6CAMK1G2.98568404
7DAPK22.96108273
8STK38L2.81608086
9SGK4942.31725461
10SGK2232.31725461
11LATS12.26478409
12STK382.24316597
13TAOK32.03752245
14SGK32.02574484
15MARK21.89976287
16STK391.82427188
17TNK21.77915959
18MAP3K131.68873603
19WNK41.66529683
20ACVR1B1.65359146
21BMPR1B1.57840038
22MAPKAPK31.46522505
23CDC42BPA1.44186326
24PRKAA21.20588797
25CDK121.16060432
26MYLK1.12326540
27ERBB21.00186481
28OXSR10.99344113
29NME10.98841263
30BRD40.88990261
31MAP3K70.87343883
32PRKAA10.83504951
33DMPK0.78601364
34TRIB30.78301393
35MTOR0.77849805
36MAP3K40.77804154
37NLK0.72992583
38PINK10.72779428
39MELK0.69726479
40NEK60.69648411
41TRPM70.69303538
42BRSK20.68224090
43STK30.64689897
44WNK10.63515334
45ERBB30.63300274
46SGK10.61436773
47MAPK130.58346599
48DAPK10.54442964
49CSNK1A1L0.54374662
50PKN20.52487574
51PDGFRB0.52280754
52TEC0.50681673
53NUAK10.48371345
54FER0.45751222
55PAK20.43987030
56FGFR30.41781252
57MAPK150.40301642
58OBSCN0.39724639
59GRK70.39503337
60RPS6KB20.39250656
61MKNK20.38256297
62WNK30.37606480
63CHUK0.37571665
64CAMK10.37372251
65TGFBR10.36924516
66DAPK30.36764935
67BRAF0.35974984
68EIF2AK30.32535174
69INSRR0.32385907
70MAP2K70.30612355
71RPS6KA20.30413825
72MAP3K20.30317440
73MAP2K20.29959321
74GSK3A0.29723016
75STK110.28902744
76MAPKAPK50.28234447
77AKT10.27873525
78PIK3CA0.26555574
79MAP2K60.26019405
80PRKD30.24181601
81PRKACA0.23273407
82NEK20.23268516
83GSK3B0.23173629
84MAP4K20.22646749
85PDK10.21669292
86MAPK10.21264185
87EIF2AK10.21015377
88TLK10.21008110
89RPS6KA30.20975539
90EIF2AK20.20644471
91TGFBR20.20187047
92PRKACG0.19862617
93RPS6KB10.19227297
94CAMKK20.18480819
95RPS6KA50.18364680
96MARK30.18083591
97CDK10.18065297
98MAPK80.17955564
99MAPK140.17493030
100MOS0.17367158

Predicted pathways (KEGG)

RankGene SetZ-score
1ABC transporters_Homo sapiens_hsa020103.65298658
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.45010118
3Bile secretion_Homo sapiens_hsa049762.96843216
4beta-Alanine metabolism_Homo sapiens_hsa004102.79565175
5Prostate cancer_Homo sapiens_hsa052152.56856421
6Butanoate metabolism_Homo sapiens_hsa006502.54361668
7Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.18229780
8Fatty acid biosynthesis_Homo sapiens_hsa000612.16123010
9mTOR signaling pathway_Homo sapiens_hsa041501.93986337
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92945726
11Mineral absorption_Homo sapiens_hsa049781.90200430
12Histidine metabolism_Homo sapiens_hsa003401.87082459
13Olfactory transduction_Homo sapiens_hsa047401.86115425
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.84980414
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.84663270
16Vitamin digestion and absorption_Homo sapiens_hsa049771.74007731
17Lysine degradation_Homo sapiens_hsa003101.72494778
18Longevity regulating pathway - mammal_Homo sapiens_hsa042111.71016916
19Arginine and proline metabolism_Homo sapiens_hsa003301.66751409
20Tryptophan metabolism_Homo sapiens_hsa003801.61265591
21Fatty acid metabolism_Homo sapiens_hsa012121.54194089
22Ovarian steroidogenesis_Homo sapiens_hsa049131.50676394
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49795019
24FoxO signaling pathway_Homo sapiens_hsa040681.47828406
25AMPK signaling pathway_Homo sapiens_hsa041521.46426908
26Circadian rhythm_Homo sapiens_hsa047101.38552935
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.38020084
28Type II diabetes mellitus_Homo sapiens_hsa049301.34501312
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.32853671
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30776703
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29444995
32Retinol metabolism_Homo sapiens_hsa008301.22852788
33Renin-angiotensin system_Homo sapiens_hsa046141.20923250
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.19835242
35Linoleic acid metabolism_Homo sapiens_hsa005911.10861807
36Nitrogen metabolism_Homo sapiens_hsa009101.10790409
37Pancreatic secretion_Homo sapiens_hsa049721.10253517
38MicroRNAs in cancer_Homo sapiens_hsa052061.07992830
39Phenylalanine metabolism_Homo sapiens_hsa003601.07524457
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.06722730
41Propanoate metabolism_Homo sapiens_hsa006401.06372671
42cAMP signaling pathway_Homo sapiens_hsa040241.03068212
43Insulin resistance_Homo sapiens_hsa049311.00234849
44Renin secretion_Homo sapiens_hsa049240.95675524
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89267283
46Inositol phosphate metabolism_Homo sapiens_hsa005620.85386849
47Fatty acid degradation_Homo sapiens_hsa000710.84714676
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83131569
49Insulin secretion_Homo sapiens_hsa049110.81056454
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80998796
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79893099
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.79173218
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76806559
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.76037885
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74414426
56Salivary secretion_Homo sapiens_hsa049700.73721369
57Long-term depression_Homo sapiens_hsa047300.73617480
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72157573
59Oxytocin signaling pathway_Homo sapiens_hsa049210.69905925
60Chemical carcinogenesis_Homo sapiens_hsa052040.69892990
61Dorso-ventral axis formation_Homo sapiens_hsa043200.69651884
62Glucagon signaling pathway_Homo sapiens_hsa049220.69290860
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67186285
64Adherens junction_Homo sapiens_hsa045200.63664978
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61044637
66Insulin signaling pathway_Homo sapiens_hsa049100.58718169
67Sphingolipid metabolism_Homo sapiens_hsa006000.57654980
68Selenocompound metabolism_Homo sapiens_hsa004500.56715223
69Endometrial cancer_Homo sapiens_hsa052130.55609390
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55151029
71Hedgehog signaling pathway_Homo sapiens_hsa043400.54059736
72TGF-beta signaling pathway_Homo sapiens_hsa043500.52652345
73Phototransduction_Homo sapiens_hsa047440.50809123
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50808942
75Glycerolipid metabolism_Homo sapiens_hsa005610.49403524
76Circadian entrainment_Homo sapiens_hsa047130.48022604
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47938118
78Arachidonic acid metabolism_Homo sapiens_hsa005900.47352004
79Melanoma_Homo sapiens_hsa052180.46944046
80Cholinergic synapse_Homo sapiens_hsa047250.46357990
81Serotonergic synapse_Homo sapiens_hsa047260.46192288
82Glioma_Homo sapiens_hsa052140.45823162
83Acute myeloid leukemia_Homo sapiens_hsa052210.45208440
84MAPK signaling pathway_Homo sapiens_hsa040100.42634351
85Arginine biosynthesis_Homo sapiens_hsa002200.41226532
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40937360
87Taste transduction_Homo sapiens_hsa047420.40806215
88Amphetamine addiction_Homo sapiens_hsa050310.40580370
89Thyroid cancer_Homo sapiens_hsa052160.40431668
90Morphine addiction_Homo sapiens_hsa050320.40321900
91Glutathione metabolism_Homo sapiens_hsa004800.39685958
92Choline metabolism in cancer_Homo sapiens_hsa052310.38172057
93Calcium signaling pathway_Homo sapiens_hsa040200.38020737
94Peroxisome_Homo sapiens_hsa041460.36539634
95ErbB signaling pathway_Homo sapiens_hsa040120.36510739
96Tyrosine metabolism_Homo sapiens_hsa003500.35903233
97Tight junction_Homo sapiens_hsa045300.35457121
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34439008
99Ether lipid metabolism_Homo sapiens_hsa005650.34074404
100Oocyte meiosis_Homo sapiens_hsa041140.33582727

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