ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of meiosis I (GO:0060631)	5.85715343
2	fatty acid elongation (GO:0030497)	4.86132047
3	male meiosis (GO:0007140)	4.65192066
4	dicarboxylic acid catabolic process (GO:0043649)	4.58164668
5	synapsis (GO:0007129)	4.40163663
6	regulation of cilium movement (GO:0003352)	4.36045209
7	microtubule depolymerization (GO:0007019)	4.24033930
8	histone exchange (GO:0043486)	4.14162726
9	nuclear pore complex assembly (GO:0051292)	4.14117987
10	negative regulation of meiosis (GO:0045835)	4.12787779
11	multicellular organism reproduction (GO:0032504)	4.04304674
12	motile cilium assembly (GO:0044458)	4.01659441
13	binding of sperm to zona pellucida (GO:0007339)	3.88333897
14	sperm-egg recognition (GO:0035036)	3.84762470
15	acrosome reaction (GO:0007340)	3.83851946
16	male sex determination (GO:0030238)	3.82265745
17	protein-DNA complex disassembly (GO:0032986)	3.75176610
18	nucleosome disassembly (GO:0006337)	3.75176610
19	pore complex assembly (GO:0046931)	3.75060871
20	one-carbon compound transport (GO:0019755)	3.73183119
21	DNA replication checkpoint (GO:0000076)	3.72577970
22	proline biosynthetic process (GO:0006561)	3.72284835
23	nuclear pore organization (GO:0006999)	3.71479486
24	DNA strand renaturation (GO:0000733)	3.63580293
25	mitotic chromosome condensation (GO:0007076)	3.62360813
26	regulation of translational fidelity (GO:0006450)	3.55086730
27	replication fork processing (GO:0031297)	3.52720489
28	DNA double-strand break processing (GO:0000729)	3.47828629
29	sex differentiation (GO:0007548)	3.45572379
30	cullin deneddylation (GO:0010388)	3.41629946
31	cilium or flagellum-dependent cell motility (GO:0001539)	3.41594594
32	axonemal dynein complex assembly (GO:0070286)	3.41055203
33	ribosome assembly (GO:0042255)	3.39626612
34	positive regulation of male gonad development (GO:2000020)	3.37294600
35	glutamine family amino acid biosynthetic process (GO:0009084)	3.36529230
36	coenzyme catabolic process (GO:0009109)	3.34959815
37	spermatid development (GO:0007286)	3.33921079
38	tRNA aminoacylation for protein translation (GO:0006418)	3.24259057
39	mitotic metaphase plate congression (GO:0007080)	3.21659024
40	sister chromatid cohesion (GO:0007062)	3.19842051
41	tRNA aminoacylation (GO:0043039)	3.16253148
42	amino acid activation (GO:0043038)	3.16253148
43	protein localization to kinetochore (GO:0034501)	3.16151533
44	glutamine family amino acid catabolic process (GO:0009065)	3.14739207
45	diterpenoid biosynthetic process (GO:0016102)	3.14619465
46	chromosome condensation (GO:0030261)	3.12204716
47	mitotic sister chromatid cohesion (GO:0007064)	3.11163040
48	DNA replication initiation (GO:0006270)	3.10677145
49	CENP-A containing nucleosome assembly (GO:0034080)	3.08755306
50	homocysteine metabolic process (GO:0050667)	3.07265419
51	chromosome organization involved in meiosis (GO:0070192)	3.05882798
52	cell-cell recognition (GO:0009988)	3.05828027
53	fusion of sperm to egg plasma membrane (GO:0007342)	3.05794396
54	mitochondrial RNA metabolic process (GO:0000959)	3.04181855
55	meiotic chromosome segregation (GO:0045132)	3.03382119
56	oxaloacetate metabolic process (GO:0006107)	3.02479945
57	metaphase plate congression (GO:0051310)	3.00598215
58	cellular zinc ion homeostasis (GO:0006882)	3.00270777
59	cellular response to leptin stimulus (GO:0044320)	2.99904671
60	protein localization to chromosome, centromeric region (GO:0071459)	2.99586278
61	sperm motility (GO:0030317)	2.99170788
62	protein deneddylation (GO:0000338)	2.95125116
63	peptidyl-lysine dimethylation (GO:0018027)	2.94958496
64	resolution of meiotic recombination intermediates (GO:0000712)	2.91567019
65	regulation of relaxation of muscle (GO:1901077)	2.89963889
66	intra-S DNA damage checkpoint (GO:0031573)	2.89112076
67	oogenesis (GO:0048477)	2.88210470
68	reproduction (GO:0000003)	2.87562858
69	mitotic sister chromatid segregation (GO:0000070)	2.86703983
70	polyamine biosynthetic process (GO:0006596)	2.86618030
71	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.84988929
72	DNA integration (GO:0015074)	2.84969328
73	meiotic nuclear division (GO:0007126)	2.83754626
74	DNA packaging (GO:0006323)	2.82893779
75	chromatin remodeling at centromere (GO:0031055)	2.81587060
76	chaperone-mediated protein complex assembly (GO:0051131)	2.81563920
77	tricarboxylic acid cycle (GO:0006099)	2.81350916
78	sister chromatid segregation (GO:0000819)	2.81283732
79	histone H2A acetylation (GO:0043968)	2.78422702
80	proline metabolic process (GO:0006560)	2.78211827
81	protein-cofactor linkage (GO:0018065)	2.77036993
82	rRNA methylation (GO:0031167)	2.76873142
83	microtubule polymerization or depolymerization (GO:0031109)	2.76161469
84	AMP metabolic process (GO:0046033)	2.74919881
85	gonadal mesoderm development (GO:0007506)	2.74591832
86	succinate metabolic process (GO:0006105)	2.73557396
87	rRNA modification (GO:0000154)	2.71655846
88	oxidative phosphorylation (GO:0006119)	2.70303603
89	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.68906223
90	ATP-dependent chromatin remodeling (GO:0043044)	2.68851041
91	single fertilization (GO:0007338)	2.67504616
92	positive regulation of p38MAPK cascade (GO:1900745)	2.66943101
93	response to misfolded protein (GO:0051788)	2.66268386
94	negative regulation of meiotic cell cycle (GO:0051447)	2.65334191
95	regulation of inclusion body assembly (GO:0090083)	2.64447514
96	microtubule severing (GO:0051013)	2.63985157
97	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.62712364
98	DNA catabolic process, exonucleolytic (GO:0000738)	2.61689623
99	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.59949249
100	gas transport (GO:0015669)	2.57338859

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.14141495
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.29733533
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.80010740
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.38745761
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.24964054
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.22674467
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.12169954
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.05293844
9	AR_21909140_ChIP-Seq_LNCAP_Human	2.91032622
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.80693598
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.79402644
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.70743657
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.61456426
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.45700714
15	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.44458606
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44162988
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.39232084
18	ZNF263_19887448_ChIP-Seq_K562_Human	2.35288003
19	DCP1A_22483619_ChIP-Seq_HELA_Human	2.31080492
20	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.29093800
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.18033931
22	IGF1R_20145208_ChIP-Seq_DFB_Human	2.16971844
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.99149359
24	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.93967808
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88878615
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.86749267
27	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.81732844
28	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.78389790
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.78083747
30	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.77551146
31	VDR_22108803_ChIP-Seq_LS180_Human	1.73229122
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.72412513
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64490947
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.64136261
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.62882880
36	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.62600681
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.60996137
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.58897198
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.57575822
40	KDM5A_27292631_Chip-Seq_BREAST_Human	1.56150112
41	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.54889684
42	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.52605028
43	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.52385925
44	XRN2_22483619_ChIP-Seq_HELA_Human	1.51794839
45	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.49506072
46	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.43048228
47	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.42485753
48	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.37427249
49	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.35249023
50	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.32797174
51	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.30151643
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.29824521
53	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.29731667
54	CIITA_25753668_ChIP-Seq_RAJI_Human	1.28825082
55	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.26194214
56	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.25992546
57	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.25910551
58	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.25391878
59	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25345083
60	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.24361090
61	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.23905370
62	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.22950134
63	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22064052
64	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.20566164
65	NCOR1_26117541_ChIP-Seq_K562_Human	1.19297468
66	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.16440646
67	GATA1_19941826_ChIP-Seq_K562_Human	1.10941452
68	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.10161761
69	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.08660712
70	FUS_26573619_Chip-Seq_HEK293_Human	1.07479901
71	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.04409537
72	ER_23166858_ChIP-Seq_MCF-7_Human	1.04143772
73	MYC_18940864_ChIP-ChIP_HL60_Human	1.03196641
74	CTCF_20526341_ChIP-Seq_ESCs_Human	0.99619941
75	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.99264496
76	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.98944772
77	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.96485154
78	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.95912082
79	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.92929048
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92268007
81	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91911680
82	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.89298122
83	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.87951774
84	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.87633961
85	CBP_20019798_ChIP-Seq_JUKART_Human	0.87626142
86	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.87626142
87	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.87461596
88	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87238008
89	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.87055750
90	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.86899643
91	PHF8_20622853_ChIP-Seq_HELA_Human	0.86015382
92	ERG_20517297_ChIP-Seq_VCAP_Human	0.85524063
93	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.84693708
94	TFEB_21752829_ChIP-Seq_HELA_Human	0.84227642
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.83984624
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.83734846
97	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.81362164
98	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.81094180
99	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.80705371
100	ETV1_20927104_ChIP-Seq_GIST48_Human	0.80661212

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	5.32243117
2	MP0008995_early_reproductive_senescence	3.42633521
3	MP0001661_extended_life_span	3.40585420
4	MP0003806_abnormal_nucleotide_metabolis	3.27665819
5	MP0008058_abnormal_DNA_repair	3.12604596
6	MP0005645_abnormal_hypothalamus_physiol	3.02504080
7	MP0003693_abnormal_embryo_hatching	2.73925363
8	MP0001929_abnormal_gametogenesis	2.58328908
9	MP0002132_abnormal_respiratory_system	2.57773302
10	MP0004957_abnormal_blastocyst_morpholog	2.51956565
11	MP0003718_maternal_effect	2.47915207
12	MP0003111_abnormal_nucleus_morphology	2.39415963
13	MP0008004_abnormal_stomach_pH	2.38442478
14	MP0010094_abnormal_chromosome_stability	2.34054149
15	MP0001984_abnormal_olfaction	2.22050026
16	MP0003698_abnormal_male_reproductive	2.19270706
17	MP0003077_abnormal_cell_cycle	2.12137536
18	MP0001502_abnormal_circadian_rhythm	2.11198981
19	MP0009697_abnormal_copulation	2.10706014
20	MP0000751_myopathy	2.04297684
21	MP0006035_abnormal_mitochondrial_morpho	2.01922110
22	MP0002210_abnormal_sex_determination	1.98655240
23	MP0004147_increased_porphyrin_level	1.96953285
24	MP0000647_abnormal_sebaceous_gland	1.95183251
25	MP0008007_abnormal_cellular_replicative	1.91488940
26	MP0002160_abnormal_reproductive_system	1.89346541
27	MP0003315_abnormal_perineum_morphology	1.80481019
28	MP0001968_abnormal_touch/_nociception	1.70769905
29	MP0008932_abnormal_embryonic_tissue	1.70264915
30	MP0000383_abnormal_hair_follicle	1.68824455
31	MP0008877_abnormal_DNA_methylation	1.59164224
32	MP0001764_abnormal_homeostasis	1.54278408
33	MP0006036_abnormal_mitochondrial_physio	1.51558094
34	MP0001145_abnormal_male_reproductive	1.49268527
35	MP0004233_abnormal_muscle_weight	1.46020871
36	MP0003786_premature_aging	1.42902331
37	MP0005187_abnormal_penis_morphology	1.42491036
38	MP0005253_abnormal_eye_physiology	1.37316217
39	MP0000653_abnormal_sex_gland	1.36758669
40	MP0003186_abnormal_redox_activity	1.35150512
41	MP0003136_yellow_coat_color	1.32945024
42	MP0008260_abnormal_autophagy	1.31036216
43	MP0004145_abnormal_muscle_electrophysio	1.30323759
44	MP0002161_abnormal_fertility/fecundity	1.28388524
45	MP0008775_abnormal_heart_ventricle	1.28093282
46	MP0003656_abnormal_erythrocyte_physiolo	1.27585538
47	MP0001853_heart_inflammation	1.20777539
48	MP0002736_abnormal_nociception_after	1.18400058
49	MP0000678_abnormal_parathyroid_gland	1.12679960
50	MP0002734_abnormal_mechanical_nocicepti	1.10424822
51	MP0000427_abnormal_hair_cycle	1.09685754
52	MP0001905_abnormal_dopamine_level	1.09211371
53	MP0001529_abnormal_vocalization	1.07988761
54	MP0000358_abnormal_cell_content/	1.07764883
55	MP0003045_fibrosis	1.05943177
56	MP0005332_abnormal_amino_acid	1.05662660
57	MP0006072_abnormal_retinal_apoptosis	1.04443164
58	MP0005389_reproductive_system_phenotype	1.03159389
59	MP0000747_muscle_weakness	0.97124704
60	MP0005395_other_phenotype	0.97076087
61	MP0000579_abnormal_nail_morphology	0.96981081
62	MP0010678_abnormal_skin_adnexa	0.96331594
63	MP0001730_embryonic_growth_arrest	0.94755415
64	MP0002080_prenatal_lethality	0.90548492
65	MP0001727_abnormal_embryo_implantation	0.90354886
66	MP0000313_abnormal_cell_death	0.89550341
67	MP0005499_abnormal_olfactory_system	0.89189897
68	MP0005394_taste/olfaction_phenotype	0.89189897
69	MP0002095_abnormal_skin_pigmentation	0.89139407
70	MP0008770_decreased_survivor_rate	0.88950438
71	MP0004264_abnormal_extraembryonic_tissu	0.87823158
72	MP0003936_abnormal_reproductive_system	0.87820785
73	MP0005083_abnormal_biliary_tract	0.87194388
74	MP0009046_muscle_twitch	0.87140484
75	MP0005551_abnormal_eye_electrophysiolog	0.87100051
76	MP0002751_abnormal_autonomic_nervous	0.86237203
77	MP0008789_abnormal_olfactory_epithelium	0.85692962
78	MP0000749_muscle_degeneration	0.83674283
79	MP0006276_abnormal_autonomic_nervous	0.82387326
80	MP0000350_abnormal_cell_proliferation	0.75926729
81	MP0004084_abnormal_cardiac_muscle	0.75870822
82	MP0004782_abnormal_surfactant_physiolog	0.75660726
83	MP0000627_abnormal_mammary_gland	0.73455700
84	MP0002638_abnormal_pupillary_reflex	0.73343615
85	MP0005380_embryogenesis_phenotype	0.72124590
86	MP0001672_abnormal_embryogenesis/_devel	0.72124590
87	MP0005647_abnormal_sex_gland	0.71689254
88	MP0001986_abnormal_taste_sensitivity	0.70295678
89	MP0004215_abnormal_myocardial_fiber	0.69688406
90	MP0005636_abnormal_mineral_homeostasis	0.67264247
91	MP0003221_abnormal_cardiomyocyte_apopto	0.66318507
92	MP0004043_abnormal_pH_regulation	0.66051145
93	MP0001545_abnormal_hematopoietic_system	0.65951599
94	MP0005397_hematopoietic_system_phenotyp	0.65951599
95	MP0002084_abnormal_developmental_patter	0.62292377
96	MP0001919_abnormal_reproductive_system	0.61548562
97	MP0005535_abnormal_body_temperature	0.61236017
98	MP0002735_abnormal_chemical_nociception	0.61180603
99	MP0002269_muscular_atrophy	0.61088981
100	MP0001697_abnormal_embryo_size	0.60971644

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Unilateral renal agenesis (HP:0000122)	5.01254114
2	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.57482255
3	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.57482255
4	Pili torti (HP:0003777)	4.20193980
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.39847970
6	Absent/shortened dynein arms (HP:0200106)	3.39847970
7	Ependymoma (HP:0002888)	3.39023479
8	Hyperthyroidism (HP:0000836)	3.31327975
9	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.23278300
10	Truncus arteriosus (HP:0001660)	3.18129037
11	Abnormal respiratory motile cilium physiology (HP:0012261)	3.13422159
12	Abnormal ciliary motility (HP:0012262)	3.00180360
13	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.97023828
14	Cholecystitis (HP:0001082)	2.95198110
15	Abnormal gallbladder physiology (HP:0012438)	2.95198110
16	Infertility (HP:0000789)	2.91565693
17	Shoulder girdle muscle weakness (HP:0003547)	2.83862967
18	Abnormal hair laboratory examination (HP:0003328)	2.81775312
19	Abnormal respiratory epithelium morphology (HP:0012253)	2.79560600
20	Abnormal respiratory motile cilium morphology (HP:0005938)	2.79560600
21	Ragged-red muscle fibers (HP:0003200)	2.74499677
22	Male pseudohermaphroditism (HP:0000037)	2.68479685
23	Glioma (HP:0009733)	2.67701261
24	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.65194946
25	Chromsome breakage (HP:0040012)	2.59825203
26	Tubulointerstitial nephritis (HP:0001970)	2.59330343
27	Cerebellar dysplasia (HP:0007033)	2.58866562
28	Spastic tetraparesis (HP:0001285)	2.56904974
29	Decreased lacrimation (HP:0000633)	2.53301120
30	Hypoparathyroidism (HP:0000829)	2.47948759
31	Reticulocytosis (HP:0001923)	2.42684128
32	Neonatal respiratory distress (HP:0002643)	2.40683005
33	Atelectasis (HP:0100750)	2.35692414
34	Gonadal dysgenesis (HP:0000133)	2.34807986
35	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.26732599
36	Abnormality of the vocal cords (HP:0008777)	2.25975982
37	Methylmalonic aciduria (HP:0012120)	2.25647891
38	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.25336796
39	Septo-optic dysplasia (HP:0100842)	2.24979899
40	Hypoplasia of the uterus (HP:0000013)	2.22954083
41	Abnormality of the astrocytes (HP:0100707)	2.22927579
42	Astrocytoma (HP:0009592)	2.22927579
43	Facial cleft (HP:0002006)	2.21202345
44	Abnormality of reticulocytes (HP:0004312)	2.20785794
45	Abnormality of the preputium (HP:0100587)	2.19873891
46	Birth length less than 3rd percentile (HP:0003561)	2.19725252
47	Resting tremor (HP:0002322)	2.19034884
48	Insidious onset (HP:0003587)	2.18369939
49	Termporal pattern (HP:0011008)	2.18369939
50	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	2.18005077
51	Alacrima (HP:0000522)	2.16140044
52	Abnormality of homocysteine metabolism (HP:0010919)	2.14946781
53	Homocystinuria (HP:0002156)	2.14946781
54	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.13678741
55	Abnormality of cochlea (HP:0000375)	2.13582807
56	Poikilocytosis (HP:0004447)	2.13547728
57	Sex reversal (HP:0012245)	2.13100968
58	Abnormal sex determination (HP:0012244)	2.13100968
59	Abnormality of methionine metabolism (HP:0010901)	2.12867647
60	Thyroid-stimulating hormone excess (HP:0002925)	2.08624158
61	Type II lissencephaly (HP:0007260)	2.07461112
62	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.04433082
63	Follicular hyperkeratosis (HP:0007502)	2.04301661
64	Abnormality of macular pigmentation (HP:0008002)	2.02738406
65	Dry hair (HP:0011359)	2.02067887
66	Agnosia (HP:0010524)	2.00466941
67	Abnormality of the ileum (HP:0001549)	1.97872680
68	Polycythemia (HP:0001901)	1.96613944
69	Autoamputation (HP:0001218)	1.96368074
70	Hyperbilirubinemia (HP:0002904)	1.96082738
71	Ankyloglossia (HP:0010296)	1.95658225
72	Congenital primary aphakia (HP:0007707)	1.94546495
73	Recurrent corneal erosions (HP:0000495)	1.92877858
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92500970
75	Sensorimotor neuropathy (HP:0007141)	1.91729250
76	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.91342059
77	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.90062989
78	Duodenal stenosis (HP:0100867)	1.88727635
79	Small intestinal stenosis (HP:0012848)	1.88727635
80	Poor head control (HP:0002421)	1.88640367
81	High pitched voice (HP:0001620)	1.88293420
82	Abnormality of chromosome stability (HP:0003220)	1.86834188
83	Facial hemangioma (HP:0000329)	1.86180847
84	Meckel diverticulum (HP:0002245)	1.84890636
85	Bowel incontinence (HP:0002607)	1.83698660
86	Methylmalonic acidemia (HP:0002912)	1.83483750
87	Hypotelorism (HP:0000601)	1.82243911
88	Male infertility (HP:0003251)	1.81552026
89	Gait imbalance (HP:0002141)	1.80816290
90	Self-mutilation (HP:0000742)	1.79072484
91	Abnormal large intestine physiology (HP:0012700)	1.78709143
92	Urinary urgency (HP:0000012)	1.78279084
93	Poor coordination (HP:0002370)	1.77062875
94	Papilledema (HP:0001085)	1.76820978
95	Hand muscle atrophy (HP:0009130)	1.74654467
96	Reticulocytopenia (HP:0001896)	1.74555978
97	Type I transferrin isoform profile (HP:0003642)	1.73718754
98	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.73574622
99	Absent epiphyses (HP:0010577)	1.73574622
100	Pancreatic islet-cell hyperplasia (HP:0004510)	1.71471261

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.66477095
2	PINK1	3.66408147
3	EIF2AK1	2.88695902
4	NEK6	2.80774366
5	EIF2AK3	2.46950376
6	PBK	2.38760751
7	TLK1	2.38756860
8	PLK4	2.14581093
9	TTK	2.03052555
10	PDK2	10.0589450
11	NEK1	1.80694549
12	BUB1	1.61115341
13	MET	1.60442922
14	BMX	1.59389543
15	NEK2	1.57096156
16	PNCK	1.51769768
17	MARK3	1.51369013
18	CCNB1	1.38103949
19	WEE1	1.29496683
20	TSSK6	1.24420502
21	KSR2	1.22421805
22	PLK1	1.18969489
23	CLK1	1.14125843
24	STK38	1.10114045
25	SCYL2	1.08993158
26	LATS1	1.07876604
27	NTRK2	1.06015993
28	PTK2B	1.05789452
29	MAP3K2	1.03814172
30	CDC7	1.01788510
31	SRPK1	0.96719519
32	CDK19	0.94010773
33	IRAK3	0.90994292
34	RPS6KA5	0.89575910
35	NME2	0.88807616
36	CDK3	0.84153287
37	BMPR1B	0.84062429
38	RAF1	0.83165400
39	BRSK2	0.80933387
40	NTRK3	0.79931879
41	CDK8	0.77565545
42	STK4	0.74754767
43	ATR	0.74295758
44	MINK1	0.70847188
45	TEC	0.70191650
46	MATK	0.69439872
47	NME1	0.69031415
48	ATM	0.68505446
49	AURKB	0.68088446
50	INSRR	0.67658509
51	CDK12	0.65943755
52	PLK3	0.63135802
53	WNK3	0.62450746
54	PDPK1	0.60477197
55	CHEK1	0.59308939
56	MST4	0.57904630
57	MYLK	0.56654615
58	CHEK2	0.56366918
59	EEF2K	0.55057100
60	MAP3K6	0.53286848
61	ERBB3	0.53179904
62	CDK14	0.51367107
63	IRAK2	0.51293462
64	MST1R	0.50291062
65	PAK6	0.49331785
66	MAPK12	0.48515939
67	AURKA	0.47213942
68	CDK1	0.46248050
69	MAP3K4	0.45723059
70	PAK1	0.44584553
71	AKT2	0.44104488
72	BMPR2	0.43569039
73	YES1	0.42839500
74	MAP3K8	0.41829112
75	MAP2K7	0.41452173
76	BRSK1	0.41269308
77	BRD4	0.39885100
78	ARAF	0.39705336
79	CDK2	0.39406887
80	BCKDK	0.38355889
81	RET	0.37818502
82	MTOR	0.37100668
83	MAPK15	0.36775696
84	STK3	0.35466502
85	PAK2	0.35333525
86	NTRK1	0.34678700
87	KSR1	0.33580911
88	BRAF	0.32939852
89	PDK1	0.31160294
90	CDK11A	0.30380541
91	TRPM7	0.29712780
92	TESK2	0.28358327
93	PIM1	0.28160807
94	PASK	0.27510300
95	ITK	0.27160947
96	CSNK2A2	0.26088146
97	MAPK7	0.24778540
98	CDK15	0.24002004
99	MAP3K5	0.23022473
100	CSNK2A1	0.21688715

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.66082700
2	Fatty acid elongation_Homo sapiens_hsa00062	3.25210258
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.06457544
4	Homologous recombination_Homo sapiens_hsa03440	2.88638670
5	Mismatch repair_Homo sapiens_hsa03430	2.87269981
6	Pyruvate metabolism_Homo sapiens_hsa00620	2.66550542
7	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.56413488
8	Propanoate metabolism_Homo sapiens_hsa00640	2.51961942
9	One carbon pool by folate_Homo sapiens_hsa00670	2.50108905
10	DNA replication_Homo sapiens_hsa03030	2.44587923
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.43047393
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.33204290
13	Proteasome_Homo sapiens_hsa03050	2.32609248
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.16440110
15	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.12118320
16	RNA transport_Homo sapiens_hsa03013	2.05969262
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.91982000
18	Fatty acid metabolism_Homo sapiens_hsa01212	1.86261262
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.77967002
20	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.70923579
21	Arginine biosynthesis_Homo sapiens_hsa00220	1.62841134
22	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.62300709
23	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.59151095
24	Olfactory transduction_Homo sapiens_hsa04740	1.56250650
25	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.55512610
26	Butanoate metabolism_Homo sapiens_hsa00650	1.54046629
27	Carbon metabolism_Homo sapiens_hsa01200	1.53513909
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.50631643
29	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.41344953
30	Oocyte meiosis_Homo sapiens_hsa04114	1.39984846
31	mRNA surveillance pathway_Homo sapiens_hsa03015	1.38759029
32	RNA polymerase_Homo sapiens_hsa03020	1.37920759
33	Spliceosome_Homo sapiens_hsa03040	1.37319649
34	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.35948445
35	Purine metabolism_Homo sapiens_hsa00230	1.34519778
36	Basal transcription factors_Homo sapiens_hsa03022	1.33466368
37	Glutathione metabolism_Homo sapiens_hsa00480	1.32965706
38	Cell cycle_Homo sapiens_hsa04110	1.30635739
39	Oxidative phosphorylation_Homo sapiens_hsa00190	1.25735310
40	Parkinsons disease_Homo sapiens_hsa05012	1.24876636
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.19087237
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18603401
43	Gap junction_Homo sapiens_hsa04540	1.15152479
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.14325122
45	RNA degradation_Homo sapiens_hsa03018	1.07353661
46	Other glycan degradation_Homo sapiens_hsa00511	1.03558940
47	Base excision repair_Homo sapiens_hsa03410	0.99547396
48	Huntingtons disease_Homo sapiens_hsa05016	0.94768163
49	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93755780
50	Fatty acid degradation_Homo sapiens_hsa00071	0.91867187
51	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.90452727
52	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.90333108
53	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89708611
54	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.88927120
55	Peroxisome_Homo sapiens_hsa04146	0.87485639
56	Pentose phosphate pathway_Homo sapiens_hsa00030	0.86820026
57	Lysine degradation_Homo sapiens_hsa00310	0.86221444
58	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.85093898
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.78359469
60	Sphingolipid metabolism_Homo sapiens_hsa00600	0.71162594
61	Alcoholism_Homo sapiens_hsa05034	0.70941764
62	Tyrosine metabolism_Homo sapiens_hsa00350	0.69491495
63	Metabolic pathways_Homo sapiens_hsa01100	0.66833190
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65654842
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.63692154
66	Apoptosis_Homo sapiens_hsa04210	0.60002566
67	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.58898383
68	Renin-angiotensin system_Homo sapiens_hsa04614	0.58224935
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57600695
70	ABC transporters_Homo sapiens_hsa02010	0.56750957
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51468104
72	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.50415970
73	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.50394194
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.49329051
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48657162
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47566461
77	Phagosome_Homo sapiens_hsa04145	0.47253401
78	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.47188404
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46894593
80	Alzheimers disease_Homo sapiens_hsa05010	0.45181959
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41631911
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40961240
83	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.40742246
84	Ribosome_Homo sapiens_hsa03010	0.38752972
85	Asthma_Homo sapiens_hsa05310	0.33885937
86	Taste transduction_Homo sapiens_hsa04742	0.33031829
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.32577158
88	Phototransduction_Homo sapiens_hsa04744	0.30255748
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29656259
90	Regulation of autophagy_Homo sapiens_hsa04140	0.29156524
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.28382880
92	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.26317282
93	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.26225712
94	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.25627923
95	Phenylalanine metabolism_Homo sapiens_hsa00360	0.25554844
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.24082741
97	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.21028716
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.19785273
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.17563432
100	Retinol metabolism_Homo sapiens_hsa00830	0.16412001

CYP4F32P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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