ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	5.88578675
2	one-carbon compound transport (GO:0019755)	5.46088447
3	coenzyme catabolic process (GO:0009109)	4.72268272
4	cellular extravasation (GO:0045123)	4.54712965
5	fusion of sperm to egg plasma membrane (GO:0007342)	4.36566399
6	motile cilium assembly (GO:0044458)	4.34405878
7	histone H3-K9 demethylation (GO:0033169)	4.00683482
8	positive regulation of gamma-delta T cell activation (GO:0046645)	3.88942250
9	axonemal dynein complex assembly (GO:0070286)	3.80716853
10	regulation of gamma-delta T cell differentiation (GO:0045586)	3.76129790
11	potassium ion export (GO:0071435)	3.69355041
12	histone H3-K9 modification (GO:0061647)	3.62805379
13	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.61239788
14	regulation of protein polyubiquitination (GO:1902914)	3.58705598
15	regulation of ARF GTPase activity (GO:0032312)	3.58379272
16	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.56023749
17	sperm motility (GO:0030317)	3.54791891
18	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.45577801
19	histone H3-K9 methylation (GO:0051567)	3.45431537
20	negative regulation of erythrocyte differentiation (GO:0045647)	3.40248624
21	ventricular system development (GO:0021591)	3.30731522
22	regulation of gamma-delta T cell activation (GO:0046643)	3.29877914
23	cell wall macromolecule metabolic process (GO:0044036)	3.22008208
24	mannose metabolic process (GO:0006013)	3.19794709
25	multicellular organism reproduction (GO:0032504)	3.16041921
26	positive regulation of B cell differentiation (GO:0045579)	3.14542228
27	cell wall macromolecule catabolic process (GO:0016998)	3.12650511
28	antigen processing and presentation of endogenous antigen (GO:0019883)	3.12036726
29	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.09870752
30	phosphatidylethanolamine metabolic process (GO:0046337)	3.09204295
31	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	3.08579601
32	plasma membrane fusion (GO:0045026)	3.07782621
33	spermatid development (GO:0007286)	3.07626256
34	spermatid nucleus differentiation (GO:0007289)	3.01647991
35	axoneme assembly (GO:0035082)	3.01601636
36	negative regulation of inclusion body assembly (GO:0090084)	3.00643086
37	regulation of B cell receptor signaling pathway (GO:0050855)	3.00415383
38	male meiosis (GO:0007140)	2.98175209
39	polyol transport (GO:0015791)	2.97462397
40	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.96325104
41	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.96095159
42	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.92076365
43	negative regulation of cell killing (GO:0031342)	2.92076365
44	regulation of Rab GTPase activity (GO:0032313)	2.91601784
45	positive regulation of Rab GTPase activity (GO:0032851)	2.91601784
46	DNA methylation involved in gamete generation (GO:0043046)	2.90456994
47	B cell receptor signaling pathway (GO:0050853)	2.88075963
48	3-UTR-mediated mRNA stabilization (GO:0070935)	2.86061145
49	positive regulation of protein kinase C signaling (GO:0090037)	2.85548115
50	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.84762670
51	interkinetic nuclear migration (GO:0022027)	2.84610452
52	acrosome reaction (GO:0007340)	2.81559249
53	microglial cell activation (GO:0001774)	2.79921405
54	negative regulation of interleukin-8 production (GO:0032717)	2.77639441
55	carnitine metabolic process (GO:0009437)	2.75656697
56	positive regulation of Rap GTPase activity (GO:0032854)	2.74285542
57	regulation of B cell differentiation (GO:0045577)	2.74006193
58	response to interleukin-15 (GO:0070672)	2.73053640
59	histone H3-K36 demethylation (GO:0070544)	2.72877026
60	regulation of histone H3-K27 methylation (GO:0061085)	2.72038571
61	peptidyl-lysine dimethylation (GO:0018027)	2.70776915
62	diacylglycerol metabolic process (GO:0046339)	2.69991738
63	reproduction (GO:0000003)	2.65343183
64	piRNA metabolic process (GO:0034587)	2.64490207
65	negative regulation of histone acetylation (GO:0035067)	2.63867931
66	intracellular estrogen receptor signaling pathway (GO:0030520)	2.63562758
67	leukocyte aggregation (GO:0070486)	2.62977107
68	positive regulation of gluconeogenesis (GO:0045722)	2.59367160
69	positive thymic T cell selection (GO:0045059)	2.58155487
70	thymic T cell selection (GO:0045061)	2.56905971
71	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.56082288
72	positive regulation of granulocyte differentiation (GO:0030854)	2.54633162
73	defense response to protozoan (GO:0042832)	2.53494582
74	ether lipid metabolic process (GO:0046485)	2.53462431
75	definitive hemopoiesis (GO:0060216)	2.52480112
76	sperm capacitation (GO:0048240)	2.52240038
77	synapsis (GO:0007129)	2.49912029
78	opioid receptor signaling pathway (GO:0038003)	2.49628753
79	carnitine transport (GO:0015879)	2.49139706
80	amino-acid betaine transport (GO:0015838)	2.49139706
81	cilium movement (GO:0003341)	2.48744770
82	gamma-aminobutyric acid transport (GO:0015812)	2.47596943
83	regulation of MHC class II biosynthetic process (GO:0045346)	2.46301089
84	cell-cell recognition (GO:0009988)	2.44196180
85	establishment of protein localization to Golgi (GO:0072600)	2.43809812
86	sperm-egg recognition (GO:0035036)	2.43262608
87	negative regulation of phagocytosis (GO:0050765)	2.42510613
88	skeletal muscle adaptation (GO:0043501)	2.40478661
89	short-chain fatty acid metabolic process (GO:0046459)	2.39818825
90	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.39796765
91	alanine transport (GO:0032328)	2.36516866
92	megakaryocyte development (GO:0035855)	2.36475840
93	chromosome organization involved in meiosis (GO:0070192)	2.34765979
94	TOR signaling (GO:0031929)	2.34348440
95	histone lysine demethylation (GO:0070076)	2.34174005
96	positive regulation of vascular permeability (GO:0043117)	2.33936869
97	synaptonemal complex assembly (GO:0007130)	2.33924351
98	growth hormone receptor signaling pathway (GO:0060396)	2.33871964
99	mast cell activation involved in immune response (GO:0002279)	2.33728353
100	mast cell degranulation (GO:0043303)	2.33728353

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.47263809
2	AR_21572438_ChIP-Seq_LNCaP_Human	2.85842503
3	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.75052448
4	DROSHA_22980978_ChIP-Seq_HELA_Human	2.61233965
5	RUNX_20019798_ChIP-Seq_JUKART_Human	2.54032747
6	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.43555336
7	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.43317326
8	SCL_19346495_ChIP-Seq_HPC-7_Human	2.34685920
9	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.23858886
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.20056436
11	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.17520516
12	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	2.11412057
13	SPI1_23127762_ChIP-Seq_K562_Human	2.11005376
14	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	2.10897649
15	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.07764099
16	SMC4_20622854_ChIP-Seq_HELA_Human	2.07329574
17	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.98192115
18	MYB_26560356_Chip-Seq_TH1_Human	1.85294777
19	VDR_21846776_ChIP-Seq_THP-1_Human	1.83328150
20	P68_20966046_ChIP-Seq_HELA_Human	1.80361139
21	LXR_22292898_ChIP-Seq_THP-1_Human	1.78872711
22	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.76858158
23	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.75460232
24	MYB_26560356_Chip-Seq_TH2_Human	1.74600803
25	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.72465577
26	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.71864474
27	MAF_26560356_Chip-Seq_TH1_Human	1.67428496
28	BCOR_27268052_Chip-Seq_Bcells_Human	1.66836021
29	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.64405596
30	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.60230709
31	MAF_26560356_Chip-Seq_TH2_Human	1.58505067
32	E2F1_20622854_ChIP-Seq_HELA_Human	1.58224322
33	UTX_26944678_Chip-Seq_JUKART_Human	1.58065373
34	TCF7_22412390_ChIP-Seq_EML_Mouse	1.57872964
35	BCL6_27268052_Chip-Seq_Bcells_Human	1.57688368
36	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.56013599
37	GATA1_19941826_ChIP-Seq_K562_Human	1.55505686
38	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.55033437
39	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.52794162
40	TP63_22573176_ChIP-Seq_HFKS_Human	1.47072255
41	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.46973464
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.45239501
43	VDR_24763502_ChIP-Seq_THP-1_Human	1.44887457
44	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.44620946
45	OCT4_20526341_ChIP-Seq_ESCs_Human	1.44563012
46	ERA_21632823_ChIP-Seq_H3396_Human	1.44436397
47	PHF8_20622854_ChIP-Seq_HELA_Human	1.43990914
48	KDM2B_26808549_Chip-Seq_DND41_Human	1.42676098
49	CTCF_20526341_ChIP-Seq_ESCs_Human	1.39847124
50	RAC3_21632823_ChIP-Seq_H3396_Human	1.37925727
51	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.37924387
52	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.37560543
53	CTCF_27219007_Chip-Seq_Bcells_Human	1.36159934
54	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.35576972
55	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.35307287
56	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.34864915
57	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34732693
58	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.34222232
59	GATA2_19941826_ChIP-Seq_K562_Human	1.33991012
60	MYC_22102868_ChIP-Seq_BL_Human	1.33211234
61	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.31039179
62	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.29730035
63	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.29483961
64	GATA3_27048872_Chip-Seq_THYMUS_Human	1.28792477
65	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.28773900
66	P300_27268052_Chip-Seq_Bcells_Human	1.28647817
67	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.28570488
68	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.28567299
69	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.27365694
70	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.24257454
71	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.22820939
72	STAT1_20625510_ChIP-Seq_HELA_Human	1.22297085
73	VDR_22108803_ChIP-Seq_LS180_Human	1.21843724
74	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.21032165
75	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.17833833
76	CREB1_26743006_Chip-Seq_LNCaP_Human	1.17729647
77	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.16383049
78	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15466928
79	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14611269
80	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.13132750
81	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12681392
82	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.12313210
83	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.08691793
84	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.08377004
85	SA1_27219007_Chip-Seq_Bcells_Human	1.06950177
86	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.06503829
87	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06368564
88	SPI1_20517297_ChIP-Seq_HL60_Human	1.05871162
89	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.05113273
90	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.04248622
91	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.03932313
92	OCT4_19829295_ChIP-Seq_ESCs_Human	1.03486461
93	CEBPB_22108803_ChIP-Seq_LS180_Human	1.03032918
94	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.02645476
95	RACK7_27058665_Chip-Seq_MCF-7_Human	1.00714546
96	MYC_19829295_ChIP-Seq_ESCs_Human	1.00243997
97	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.00022402
98	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.99149994
99	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.98526516
100	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.94708193

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	4.46064270
2	MP0003136_yellow_coat_color	4.14341982
3	MP0003303_peritoneal_inflammation	3.11940071
4	MP0008004_abnormal_stomach_pH	2.98211088
5	MP0003763_abnormal_thymus_physiology	2.92901249
6	MP0002132_abnormal_respiratory_system	2.86584797
7	MP0009278_abnormal_bone_marrow	2.76254033
8	MP0009840_abnormal_foam_cell	2.48479423
9	MP0005083_abnormal_biliary_tract	2.45593173
10	MP0003191_abnormal_cellular_cholesterol	2.31564861
11	MP0002138_abnormal_hepatobiliary_system	2.29670813
12	MP0005397_hematopoietic_system_phenotyp	2.26849710
13	MP0001545_abnormal_hematopoietic_system	2.26849710
14	MP0003436_decreased_susceptibility_to	2.24456649
15	MP0004264_abnormal_extraembryonic_tissu	2.03026473
16	MP0001986_abnormal_taste_sensitivity	2.01052869
17	MP0003698_abnormal_male_reproductive	1.91637263
18	MP0001873_stomach_inflammation	1.88656701
19	MP0001664_abnormal_digestion	1.82490603
20	MP0001929_abnormal_gametogenesis	1.66128253
21	MP0005670_abnormal_white_adipose	1.64765165
22	MP0005451_abnormal_body_composition	1.64292733
23	MP0000678_abnormal_parathyroid_gland	1.63533728
24	MP0001800_abnormal_humoral_immune	1.63000653
25	MP0005085_abnormal_gallbladder_physiolo	1.61861651
26	MP0005464_abnormal_platelet_physiology	1.58826326
27	MP0008995_early_reproductive_senescence	1.50392302
28	MP0004381_abnormal_hair_follicle	1.50021802
29	MP0005310_abnormal_salivary_gland	1.49522132
30	MP0004043_abnormal_pH_regulation	1.48525938
31	MP0003045_fibrosis	1.46835675
32	MP0005365_abnormal_bile_salt	1.46507159
33	MP0003878_abnormal_ear_physiology	1.43701219
34	MP0005377_hearing/vestibular/ear_phenot	1.43701219
35	MP0001968_abnormal_touch/_nociception	1.43043753
36	MP0005671_abnormal_response_to	1.42062197
37	MP0002405_respiratory_system_inflammati	1.38290932
38	MP0003724_increased_susceptibility_to	1.37544933
39	MP0001835_abnormal_antigen_presentation	1.37176018
40	MP0004808_abnormal_hematopoietic_stem	1.28469344
41	MP0002420_abnormal_adaptive_immunity	1.27308484
42	MP0002723_abnormal_immune_serum	1.26691868
43	MP0000703_abnormal_thymus_morphology	1.25615675
44	MP0001819_abnormal_immune_cell	1.24874856
45	MP0002009_preneoplasia	1.23177877
46	MP0002398_abnormal_bone_marrow	1.22983337
47	MP0002928_abnormal_bile_duct	1.21555292
48	MP0005666_abnormal_adipose_tissue	1.19702660
49	MP0005025_abnormal_response_to	1.15911630
50	MP0002419_abnormal_innate_immunity	1.14665061
51	MP0005000_abnormal_immune_tolerance	1.14631113
52	MP0005387_immune_system_phenotype	1.11025510
53	MP0001790_abnormal_immune_system	1.11025510
54	MP0004130_abnormal_muscle_cell	1.07617960
55	MP0002933_joint_inflammation	1.07084710
56	MP0003183_abnormal_peptide_metabolism	1.05168263
57	MP0002452_abnormal_antigen_presenting	1.03585099
58	MP0000716_abnormal_immune_system	1.01937506
59	MP0002722_abnormal_immune_system	1.00197721
60	MP0001663_abnormal_digestive_system	0.98265608
61	MP0003943_abnormal_hepatobiliary_system	0.97864111
62	MP0005058_abnormal_lysosome_morphology	0.95859293
63	MP0008877_abnormal_DNA_methylation	0.95721730
64	MP0004484_altered_response_of	0.94796832
65	MP0009115_abnormal_fat_cell	0.94014881
66	MP0005535_abnormal_body_temperature	0.91888230
67	MP0001765_abnormal_ion_homeostasis	0.91389415
68	MP0003950_abnormal_plasma_membrane	0.90907407
69	MP0003011_delayed_dark_adaptation	0.90256954
70	MP0003646_muscle_fatigue	0.89565095
71	MP0003656_abnormal_erythrocyte_physiolo	0.89463001
72	MP0002653_abnormal_ependyma_morphology	0.88346777
73	MP0005647_abnormal_sex_gland	0.88248604
74	MP0008874_decreased_physiological_sensi	0.87723987
75	MP0000470_abnormal_stomach_morphology	0.87314736
76	MP0002161_abnormal_fertility/fecundity	0.86321474
77	MP0004147_increased_porphyrin_level	0.84782720
78	MP0002210_abnormal_sex_determination	0.84502690
79	MP0001145_abnormal_male_reproductive	0.83599138
80	MP0000689_abnormal_spleen_morphology	0.82758268
81	MP0002160_abnormal_reproductive_system	0.82609078
82	MP0006138_congestive_heart_failure	0.80133215
83	MP0002429_abnormal_blood_cell	0.79188986
84	MP0002277_abnormal_respiratory_mucosa	0.78911601
85	MP0003172_abnormal_lysosome_physiology	0.78694248
86	MP0010155_abnormal_intestine_physiology	0.78282488
87	MP0006082_CNS_inflammation	0.77324135
88	MP0004036_abnormal_muscle_relaxation	0.75791184
89	MP0000609_abnormal_liver_physiology	0.74596871
90	MP0001501_abnormal_sleep_pattern	0.73853075
91	MP0001845_abnormal_inflammatory_respons	0.71215453
92	MP0002118_abnormal_lipid_homeostasis	0.69612044
93	MP0000465_gastrointestinal_hemorrhage	0.67290138
94	MP0001764_abnormal_homeostasis	0.67174744
95	MP0001485_abnormal_pinna_reflex	0.66339805
96	MP0005551_abnormal_eye_electrophysiolog	0.65598524
97	MP0001533_abnormal_skeleton_physiology	0.64859147
98	MP0004947_skin_inflammation	0.64755048
99	MP0000653_abnormal_sex_gland	0.63953592
100	MP0008469_abnormal_protein_level	0.63777671

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	7.81726981
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.81726981
3	Abnormal ciliary motility (HP:0012262)	5.16739389
4	Abnormal respiratory motile cilium physiology (HP:0012261)	4.74344664
5	Abnormal respiratory epithelium morphology (HP:0012253)	4.46030750
6	Abnormal respiratory motile cilium morphology (HP:0005938)	4.46030750
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.95059118
8	Nasal polyposis (HP:0100582)	3.76777270
9	Colitis (HP:0002583)	3.74121099
10	Panhypogammaglobulinemia (HP:0003139)	3.61622915
11	Abnormality of the fingertips (HP:0001211)	3.52623890
12	Gastrointestinal inflammation (HP:0004386)	3.42743051
13	Inflammation of the large intestine (HP:0002037)	3.35981644
14	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.30481442
15	Abnormality of macrophages (HP:0004311)	3.20383208
16	Progressive cerebellar ataxia (HP:0002073)	3.15958172
17	Granulocytopenia (HP:0001913)	3.14393820
18	Gonadal dysgenesis (HP:0000133)	3.06161129
19	Abnormality of the nasal mucosa (HP:0000433)	2.98978368
20	Papilledema (HP:0001085)	2.96650967
21	Decreased central vision (HP:0007663)	2.96383608
22	Bony spicule pigmentary retinopathy (HP:0007737)	2.85850393
23	Infertility (HP:0000789)	2.84926038
24	Cerebellar dysplasia (HP:0007033)	2.83627134
25	Prolonged bleeding time (HP:0003010)	2.74439689
26	Recurrent sinusitis (HP:0011108)	2.73848585
27	Chronic obstructive pulmonary disease (HP:0006510)	2.72360746
28	Obstructive lung disease (HP:0006536)	2.72360746
29	Thrombocytosis (HP:0001894)	2.72334282
30	Abnormality of the common coagulation pathway (HP:0010990)	2.71230303
31	Increased IgE level (HP:0003212)	2.67844373
32	Eosinophilia (HP:0001880)	2.63755762
33	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.63497260
34	Male infertility (HP:0003251)	2.62977241
35	Type II lissencephaly (HP:0007260)	2.49343786
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.45375067
37	Hyperkalemia (HP:0002153)	2.42962065
38	Abnormality of the columella (HP:0009929)	2.42546466
39	Increased serum ferritin (HP:0003281)	2.40683311
40	Exercise-induced myalgia (HP:0003738)	2.38107304
41	Hypertriglyceridemia (HP:0002155)	2.37253031
42	Pustule (HP:0200039)	2.34400700
43	Eczematoid dermatitis (HP:0000976)	2.34071941
44	Epistaxis (HP:0000421)	2.31579871
45	Bronchiectasis (HP:0002110)	2.31230985
46	Hepatitis (HP:0012115)	2.27331828
47	Attenuation of retinal blood vessels (HP:0007843)	2.24295019
48	Meningitis (HP:0001287)	2.23485997
49	Recurrent fungal infections (HP:0002841)	2.22637668
50	Easy fatigability (HP:0003388)	2.22278625
51	Stomach cancer (HP:0012126)	2.18419024
52	Seborrheic dermatitis (HP:0001051)	2.15317414
53	Spontaneous abortion (HP:0005268)	2.12364760
54	Abnormality of macular pigmentation (HP:0008002)	2.11600268
55	Chronic sinusitis (HP:0011109)	2.08410987
56	Gingival bleeding (HP:0000225)	2.07731068
57	Abnormality of eosinophils (HP:0001879)	2.05446403
58	Cone-rod dystrophy (HP:0000548)	2.03341225
59	Myositis (HP:0100614)	2.01783012
60	Rhinitis (HP:0012384)	2.00124912
61	Asymmetric septal hypertrophy (HP:0001670)	2.00080688
62	Germ cell neoplasia (HP:0100728)	1.97929572
63	Bowel incontinence (HP:0002607)	1.96850281
64	Hypochromic anemia (HP:0001931)	1.96719944
65	Spontaneous hematomas (HP:0007420)	1.94460659
66	Hypoplasia of the thymus (HP:0000778)	1.94393425
67	Agammaglobulinemia (HP:0004432)	1.90185519
68	Gastrointestinal infarctions (HP:0005244)	1.88636105
69	Gastrointestinal stroma tumor (HP:0100723)	1.87645785
70	Recurrent viral infections (HP:0004429)	1.85113052
71	Abnormality of iron homeostasis (HP:0011031)	1.83951994
72	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.83773285
73	Clumsiness (HP:0002312)	1.82829539
74	Lip pit (HP:0100267)	1.81317312
75	Recurrent gram-negative bacterial infections (HP:0005420)	1.80022461
76	Large for gestational age (HP:0001520)	1.78991511
77	Severe visual impairment (HP:0001141)	1.78629248
78	Bile duct proliferation (HP:0001408)	1.77518698
79	Abnormal biliary tract physiology (HP:0012439)	1.77518698
80	Abnormal large intestine physiology (HP:0012700)	1.77137102
81	Chronic hepatic failure (HP:0100626)	1.75275669
82	Amelogenesis imperfecta (HP:0000705)	1.74693502
83	Brushfield spots (HP:0001088)	1.72901411
84	Encephalitis (HP:0002383)	1.72804239
85	Recurrent bacterial skin infections (HP:0005406)	1.71820966
86	Abnormal hemoglobin (HP:0011902)	1.70592761
87	Diplopia (HP:0000651)	1.70313400
88	Abnormality of binocular vision (HP:0011514)	1.70313400
89	Abnormality of transition element cation homeostasis (HP:0011030)	1.70249843
90	Elevated erythrocyte sedimentation rate (HP:0003565)	1.69638764
91	Hypochromic microcytic anemia (HP:0004840)	1.68842225
92	Viral hepatitis (HP:0006562)	1.68424756
93	Genetic anticipation (HP:0003743)	1.68227763
94	Vasculitis (HP:0002633)	1.68066368
95	Reticulocytosis (HP:0001923)	1.65414843
96	Recurrent abscess formation (HP:0002722)	1.63981646
97	Hemiplegia (HP:0002301)	1.63028449
98	Polycythemia (HP:0001901)	1.62300780
99	Abnormality of T cell physiology (HP:0011840)	1.61499655
100	Hyperthyroidism (HP:0000836)	1.61224138

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	2.87983762
2	RIPK4	2.75992205
3	MAP4K1	2.73475910
4	TRIB3	2.65184110
5	FRK	2.40199430
6	MARK3	2.36706710
7	MAP3K13	2.27946920
8	MAP2K3	2.08810083
9	CDK3	1.98729294
10	MAP3K2	1.95736302
11	TNK2	1.93666805
12	KSR2	1.89472871
13	STK38	1.89051598
14	MAP3K3	1.77264555
15	MAP3K7	1.75996837
16	NEK2	1.71822066
17	PRKG2	1.60580338
18	CDK19	1.60468998
19	CDK12	1.53969470
20	ZAP70	1.45942536
21	SIK2	1.43520489
22	ERN1	1.42431068
23	MAP3K1	1.41844103
24	JAK3	1.36514314
25	PTK2B	1.32279859
26	BTK	1.28213062
27	PDPK1	1.28200950
28	GRK6	1.27498027
29	SIK1	1.25701637
30	MAP4K2	1.24332561
31	PDK1	1.22353652
32	EEF2K	1.17727179
33	TAOK3	1.15802112
34	PINK1	1.13200820
35	RPS6KB2	1.12470489
36	PIK3CG	1.11190555
37	INSRR	1.11054708
38	MAP3K10	1.09221093
39	KIT	1.07981903
40	TYK2	1.07504835
41	EPHB1	1.05994538
42	MATK	1.05792487
43	RET	1.05210053
44	BMX	1.04336350
45	HCK	1.03165745
46	MARK2	0.99984484
47	NME1	0.94665422
48	PNCK	0.91165909
49	PRKCQ	0.90768423
50	FES	0.90700113
51	NTRK3	0.90518841
52	PRPF4B	0.90324090
53	OBSCN	0.90133769
54	ITK	0.87132297
55	NEK6	0.85976706
56	SYK	0.85938100
57	MAP2K6	0.83553341
58	HIPK2	0.82356153
59	TBK1	0.81243055
60	SMG1	0.80008899
61	MAPKAPK3	0.78358329
62	CAMKK1	0.78348316
63	CSF1R	0.76723554
64	IRAK4	0.76482052
65	PKN2	0.75757117
66	SGK2	0.75417938
67	FGR	0.74271823
68	JAK2	0.73632830
69	SGK3	0.73200944
70	RPS6KB1	0.71577789
71	RPS6KC1	0.71183619
72	RPS6KL1	0.71183619
73	LCK	0.70998494
74	DAPK2	0.70654365
75	RPS6KA6	0.70164447
76	SGK494	0.69095894
77	SGK223	0.69095894
78	CDC42BPA	0.67892860
79	BLK	0.65346609
80	BRD4	0.63217759
81	FGFR3	0.62563849
82	BMPR2	0.60246963
83	CDK8	0.59827435
84	STK11	0.59244314
85	LMTK2	0.58333147
86	CSK	0.56735552
87	TEC	0.56197431
88	MAPK11	0.56194538
89	MELK	0.55242464
90	MAPK12	0.54474549
91	MST1R	0.54323347
92	RPS6KA2	0.52875762
93	RAF1	0.52843637
94	CAMK1	0.52492945
95	PRKAA2	0.50764157
96	CDK4	0.49443230
97	PTK6	0.49256566
98	TRPM7	0.49252442
99	MAPK13	0.48771905
100	JAK1	0.47180069

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Olfactory transduction_Homo sapiens_hsa04740	2.38572670
2	ABC transporters_Homo sapiens_hsa02010	2.35114377
3	Allograft rejection_Homo sapiens_hsa05330	2.19052385
4	Acute myeloid leukemia_Homo sapiens_hsa05221	1.90950825
5	Graft-versus-host disease_Homo sapiens_hsa05332	1.86802354
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.80522442
7	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.67917483
8	Other glycan degradation_Homo sapiens_hsa00511	1.54504607
9	Leishmaniasis_Homo sapiens_hsa05140	1.47960673
10	mTOR signaling pathway_Homo sapiens_hsa04150	1.44233905
11	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.42859655
12	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.40129677
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.39962767
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.38088506
15	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.34852316
16	VEGF signaling pathway_Homo sapiens_hsa04370	1.33906450
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.31307284
18	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29813965
19	Platelet activation_Homo sapiens_hsa04611	1.28465042
20	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.25515414
21	Toxoplasmosis_Homo sapiens_hsa05145	1.24663873
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.20867419
23	PPAR signaling pathway_Homo sapiens_hsa03320	1.17811474
24	Choline metabolism in cancer_Homo sapiens_hsa05231	1.16745865
25	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.15604883
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.14058680
27	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.13838132
28	Salivary secretion_Homo sapiens_hsa04970	1.12717881
29	Fatty acid degradation_Homo sapiens_hsa00071	1.10790176
30	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.10672250
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.10212438
32	Asthma_Homo sapiens_hsa05310	1.09237438
33	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.08790759
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.08009722
35	Butanoate metabolism_Homo sapiens_hsa00650	1.07469498
36	Osteoclast differentiation_Homo sapiens_hsa04380	1.04790753
37	Insulin resistance_Homo sapiens_hsa04931	1.03144685
38	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.02828590
39	Non-small cell lung cancer_Homo sapiens_hsa05223	1.02730516
40	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.01575906
41	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.98371309
42	Influenza A_Homo sapiens_hsa05164	0.97564400
43	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.95623835
44	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.95498221
45	Renin secretion_Homo sapiens_hsa04924	0.93805109
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93279543
47	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.92168402
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.91874191
49	Glycerolipid metabolism_Homo sapiens_hsa00561	0.91500062
50	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.90176207
51	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.89846618
52	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.89016161
53	Type II diabetes mellitus_Homo sapiens_hsa04930	0.88332477
54	Tuberculosis_Homo sapiens_hsa05152	0.87790067
55	Estrogen signaling pathway_Homo sapiens_hsa04915	0.87333833
56	Insulin signaling pathway_Homo sapiens_hsa04910	0.85989267
57	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.85762758
58	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.85466664
59	Calcium signaling pathway_Homo sapiens_hsa04020	0.85405102
60	Measles_Homo sapiens_hsa05162	0.84398590
61	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.83721741
62	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.83694318
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.82432581
64	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.81667357
65	ErbB signaling pathway_Homo sapiens_hsa04012	0.81113847
66	African trypanosomiasis_Homo sapiens_hsa05143	0.78255565
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.77208405
68	Gap junction_Homo sapiens_hsa04540	0.76774308
69	Long-term potentiation_Homo sapiens_hsa04720	0.76451893
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75703890
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75513912
72	Gastric acid secretion_Homo sapiens_hsa04971	0.75330077
73	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.73572159
74	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.72881937
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.72113418
76	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.72020933
77	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.71936340
78	Endometrial cancer_Homo sapiens_hsa05213	0.70703002
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.67481497
80	MAPK signaling pathway_Homo sapiens_hsa04010	0.67213795
81	Circadian entrainment_Homo sapiens_hsa04713	0.65924407
82	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.65133557
83	Regulation of autophagy_Homo sapiens_hsa04140	0.64520699
84	Pancreatic secretion_Homo sapiens_hsa04972	0.64225451
85	Herpes simplex infection_Homo sapiens_hsa05168	0.63275857
86	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.63051096
87	GnRH signaling pathway_Homo sapiens_hsa04912	0.62450503
88	Long-term depression_Homo sapiens_hsa04730	0.61436156
89	FoxO signaling pathway_Homo sapiens_hsa04068	0.60740691
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.59035830
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58707301
92	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58029839
93	Apoptosis_Homo sapiens_hsa04210	0.56917647
94	Glucagon signaling pathway_Homo sapiens_hsa04922	0.55669123
95	Viral myocarditis_Homo sapiens_hsa05416	0.55030556
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.54933501
97	Glioma_Homo sapiens_hsa05214	0.53892223
98	Notch signaling pathway_Homo sapiens_hsa04330	0.53239886
99	Prolactin signaling pathway_Homo sapiens_hsa04917	0.52400055
100	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.52075263

CYP4F35P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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