ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	iron ion import (GO:0097286)	4.82529652
2	adaptation of signaling pathway (GO:0023058)	4.79542630
3	behavioral response to nicotine (GO:0035095)	4.18191205
4	response to pheromone (GO:0019236)	3.97355728
5	artery development (GO:0060840)	3.88762349
6	proline transport (GO:0015824)	3.81306145
7	reflex (GO:0060004)	3.76649931
8	biotin metabolic process (GO:0006768)	3.72453375
9	positive regulation of glycolytic process (GO:0045821)	3.71542407
10	detection of temperature stimulus (GO:0016048)	3.65692717
11	retinal metabolic process (GO:0042574)	3.64552309
12	L-fucose metabolic process (GO:0042354)	3.50536187
13	L-fucose catabolic process (GO:0042355)	3.50536187
14	fucose catabolic process (GO:0019317)	3.50536187
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.50116700
16	platelet dense granule organization (GO:0060155)	3.44504470
17	retina homeostasis (GO:0001895)	3.41649241
18	righting reflex (GO:0060013)	3.33382977
19	establishment of protein localization to Golgi (GO:0072600)	3.28634073
20	cellular ketone body metabolic process (GO:0046950)	3.25770492
21	axoneme assembly (GO:0035082)	3.25769762
22	negative regulation of systemic arterial blood pressure (GO:0003085)	3.23072963
23	ketone body metabolic process (GO:1902224)	3.20179271
24	import into cell (GO:0098657)	3.17856241
25	regulation of hexokinase activity (GO:1903299)	3.13294079
26	regulation of glucokinase activity (GO:0033131)	3.13294079
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.12798224
28	kidney morphogenesis (GO:0060993)	3.12411011
29	cilium or flagellum-dependent cell motility (GO:0001539)	3.10860928
30	protein homotrimerization (GO:0070207)	3.09213163
31	protein polyglutamylation (GO:0018095)	3.02315381
32	photoreceptor cell maintenance (GO:0045494)	3.00712201
33	protein targeting to Golgi (GO:0000042)	2.99893416
34	branched-chain amino acid catabolic process (GO:0009083)	2.99385098
35	pyrimidine nucleobase catabolic process (GO:0006208)	2.98547690
36	indole-containing compound catabolic process (GO:0042436)	2.98534983
37	indolalkylamine catabolic process (GO:0046218)	2.98534983
38	tryptophan catabolic process (GO:0006569)	2.98534983
39	adenosine metabolic process (GO:0046085)	2.96647302
40	protein localization to Golgi apparatus (GO:0034067)	2.94477228
41	piRNA metabolic process (GO:0034587)	2.93400857
42	indolalkylamine metabolic process (GO:0006586)	2.91704128
43	short-chain fatty acid metabolic process (GO:0046459)	2.89771004
44	retinol metabolic process (GO:0042572)	2.89521699
45	alanine transport (GO:0032328)	2.86046664
46	water-soluble vitamin biosynthetic process (GO:0042364)	2.85538642
47	nonmotile primary cilium assembly (GO:0035058)	2.84209137
48	protein K11-linked deubiquitination (GO:0035871)	2.84020130
49	branching involved in prostate gland morphogenesis (GO:0060442)	2.81322859
50	detection of light stimulus involved in visual perception (GO:0050908)	2.79536955
51	detection of light stimulus involved in sensory perception (GO:0050962)	2.79536955
52	benzene-containing compound metabolic process (GO:0042537)	2.79049037
53	respiratory chain complex IV assembly (GO:0008535)	2.78042116
54	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.77367780
55	mannosylation (GO:0097502)	2.76371702
56	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.75688525
57	inositol phosphate catabolic process (GO:0071545)	2.70836590
58	epithelial cilium movement (GO:0003351)	2.70794591
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70478627
60	prostate gland growth (GO:0060736)	2.69932158
61	cilium morphogenesis (GO:0060271)	2.68782201
62	nucleobase catabolic process (GO:0046113)	2.68742339
63	somite development (GO:0061053)	2.68240805
64	transepithelial transport (GO:0070633)	2.67541064
65	polyol catabolic process (GO:0046174)	2.63539458
66	kynurenine metabolic process (GO:0070189)	2.63118105
67	negative regulation of sodium ion transport (GO:0010766)	2.61057108
68	DNA methylation involved in gamete generation (GO:0043046)	2.59988468
69	regulation of cilium movement (GO:0003352)	2.59952843
70	mitotic cell cycle arrest (GO:0071850)	2.57181623
71	tryptophan metabolic process (GO:0006568)	2.55702061
72	regulation of neurotransmitter uptake (GO:0051580)	2.54948306
73	retinal ganglion cell axon guidance (GO:0031290)	2.52823467
74	GPI anchor metabolic process (GO:0006505)	2.52202943
75	protein-cofactor linkage (GO:0018065)	2.51708111
76	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.51250063
77	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.50792716
78	inositol phosphate dephosphorylation (GO:0046855)	2.50792716
79	pharyngeal system development (GO:0060037)	2.49757898
80	neuronal action potential (GO:0019228)	2.49375402
81	retinal cone cell development (GO:0046549)	2.48590792
82	DNA deamination (GO:0045006)	2.48496451
83	terpenoid biosynthetic process (GO:0016114)	2.48129501
84	nephron epithelium morphogenesis (GO:0072088)	2.47401854
85	nephron tubule morphogenesis (GO:0072078)	2.47401854
86	cornea development in camera-type eye (GO:0061303)	2.47297573
87	positive regulation of steroid hormone secretion (GO:2000833)	2.46195350
88	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.44021390
89	lung lobe morphogenesis (GO:0060463)	2.43814382
90	branched-chain amino acid metabolic process (GO:0009081)	2.42784448
91	protein localization to cilium (GO:0061512)	2.40907605
92	prenylation (GO:0097354)	2.40048860
93	protein prenylation (GO:0018342)	2.40048860
94	cAMP catabolic process (GO:0006198)	2.39330252
95	cilium organization (GO:0044782)	2.37564349
96	cilium movement (GO:0003341)	2.35649534
97	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.35584409
98	reciprocal DNA recombination (GO:0035825)	2.32620138
99	reciprocal meiotic recombination (GO:0007131)	2.32620138
100	protein-chromophore linkage (GO:0018298)	2.32024698

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.74287379
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.66833476
3	VDR_22108803_ChIP-Seq_LS180_Human	3.06188823
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.89957403
5	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.77910962
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.67220771
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.57446848
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.53564869
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.53425585
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.50472913
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.46949119
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.45768941
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.40312951
14	EWS_26573619_Chip-Seq_HEK293_Human	2.18570350
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.18295995
16	P300_19829295_ChIP-Seq_ESCs_Human	2.05988763
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97388546
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93462710
19	FUS_26573619_Chip-Seq_HEK293_Human	1.90562807
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.89249884
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.82311974
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79817691
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.79253497
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79216136
25	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.76536303
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.71136491
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.69392038
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.64407905
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.61622992
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.57957359
31	STAT3_23295773_ChIP-Seq_U87_Human	1.57017880
32	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.53008367
33	AR_25329375_ChIP-Seq_VCAP_Human	1.52729339
34	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.51760108
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.50661948
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50207790
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49539227
38	TCF4_23295773_ChIP-Seq_U87_Human	1.49328024
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48435544
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46883489
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.46188806
42	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.43729007
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.43145808
44	TCF4_22108803_ChIP-Seq_LS180_Human	1.43140804
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42053020
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41949004
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.41949004
48	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.40281490
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39481439
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.38172107
51	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.37975793
52	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.36342378
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34301692
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33571932
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33544677
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32358303
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30820884
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30820884
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30405131
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.30354073
61	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27100330
62	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25064792
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24430768
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23913059
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23764246
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23459253
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23459253
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.22146251
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20831000
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20831000
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.20541753
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19194306
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14481495
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14384844
75	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.14152891
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13595562
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12463622
78	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12350654
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12235797
80	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.11614328
81	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11379513
82	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.11096879
83	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10376509
84	CDX2_22108803_ChIP-Seq_LS180_Human	1.09831433
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08048505
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06997126
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06953662
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06929736
89	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.06697661
90	AR_20517297_ChIP-Seq_VCAP_Human	1.05443578
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.03987866
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03267676
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03236299
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03079600
95	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02380107
96	MYC_18940864_ChIP-ChIP_HL60_Human	0.99790584
97	AHR_22903824_ChIP-Seq_MCF-7_Human	0.99684956
98	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.99171086
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96742333
100	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.96604806

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	4.57794846
2	MP0002736_abnormal_nociception_after	3.81858813
3	MP0004043_abnormal_pH_regulation	3.75567229
4	MP0005167_abnormal_blood-brain_barrier	3.24297306
5	MP0001968_abnormal_touch/_nociception	3.19922544
6	MP0002102_abnormal_ear_morphology	2.99115225
7	MP0002234_abnormal_pharynx_morphology	2.70251856
8	MP0002638_abnormal_pupillary_reflex	2.57891242
9	MP0005551_abnormal_eye_electrophysiolog	2.56038162
10	MP0008877_abnormal_DNA_methylation	2.36818211
11	MP0003195_calcinosis	2.36272869
12	MP0002735_abnormal_chemical_nociception	2.31382641
13	MP0006072_abnormal_retinal_apoptosis	2.08978708
14	MP0005253_abnormal_eye_physiology	2.03145591
15	MP0000569_abnormal_digit_pigmentation	1.90502066
16	MP0005646_abnormal_pituitary_gland	1.87242053
17	MP0005084_abnormal_gallbladder_morpholo	1.86090025
18	MP0002733_abnormal_thermal_nociception	1.85767363
19	MP0002876_abnormal_thyroid_physiology	1.71252541
20	MP0000631_abnormal_neuroendocrine_gland	1.62932080
21	MP0008995_early_reproductive_senescence	1.62211830
22	MP0001501_abnormal_sleep_pattern	1.55098297
23	MP0002938_white_spotting	1.52971202
24	MP0004885_abnormal_endolymph	1.52305355
25	MP0004742_abnormal_vestibular_system	1.51736838
26	MP0003880_abnormal_central_pattern	1.48374683
27	MP0003787_abnormal_imprinting	1.47894088
28	MP0005085_abnormal_gallbladder_physiolo	1.46104972
29	MP0002837_dystrophic_cardiac_calcinosis	1.45490099
30	MP0003136_yellow_coat_color	1.45069609
31	MP0001970_abnormal_pain_threshold	1.40521686
32	MP0002928_abnormal_bile_duct	1.40178901
33	MP0005645_abnormal_hypothalamus_physiol	1.39921171
34	MP0009046_muscle_twitch	1.39813312
35	MP0000372_irregular_coat_pigmentation	1.37910804
36	MP0001485_abnormal_pinna_reflex	1.36769666
37	MP0005083_abnormal_biliary_tract	1.29377288
38	MP0004147_increased_porphyrin_level	1.29373567
39	MP0003718_maternal_effect	1.23916975
40	MP0005310_abnormal_salivary_gland	1.23231369
41	MP0001486_abnormal_startle_reflex	1.23189831
42	MP0009745_abnormal_behavioral_response	1.22404836
43	MP0000427_abnormal_hair_cycle	1.21666128
44	MP0001984_abnormal_olfaction	1.21193629
45	MP0003646_muscle_fatigue	1.19334683
46	MP0002557_abnormal_social/conspecific_i	1.18918982
47	MP0002909_abnormal_adrenal_gland	1.11765107
48	MP0002272_abnormal_nervous_system	1.09921741
49	MP0008057_abnormal_DNA_replication	1.09174779
50	MP0004133_heterotaxia	1.09103200
51	MP0000613_abnormal_salivary_gland	1.07913157
52	MP0001919_abnormal_reproductive_system	1.06512762
53	MP0005365_abnormal_bile_salt	1.04107003
54	MP0002572_abnormal_emotion/affect_behav	1.01688734
55	MP0008872_abnormal_physiological_respon	1.01537080
56	MP0005386_behavior/neurological_phenoty	1.00801786
57	MP0004924_abnormal_behavior	1.00801786
58	MP0002067_abnormal_sensory_capabilities	0.99899507
59	MP0002822_catalepsy	0.99210825
60	MP0002752_abnormal_somatic_nervous	0.96626545
61	MP0005389_reproductive_system_phenotype	0.96432049
62	MP0000230_abnormal_systemic_arterial	0.94406805
63	MP0002090_abnormal_vision	0.92946572
64	MP0005636_abnormal_mineral_homeostasis	0.92733700
65	MP0002653_abnormal_ependyma_morphology	0.92172467
66	MP0005379_endocrine/exocrine_gland_phen	0.92066631
67	MP0005195_abnormal_posterior_eye	0.92038236
68	MP0000026_abnormal_inner_ear	0.91998902
69	MP0001765_abnormal_ion_homeostasis	0.91845182
70	MP0008875_abnormal_xenobiotic_pharmacok	0.91589302
71	MP0005174_abnormal_tail_pigmentation	0.91572038
72	MP0002160_abnormal_reproductive_system	0.89929580
73	MP0003283_abnormal_digestive_organ	0.89850565
74	MP0002751_abnormal_autonomic_nervous	0.89295354
75	MP0010386_abnormal_urinary_bladder	0.88859710
76	MP0008058_abnormal_DNA_repair	0.88669191
77	MP0003122_maternal_imprinting	0.88558061
78	MP0001756_abnormal_urination	0.88304737
79	MP0001502_abnormal_circadian_rhythm	0.86502268
80	MP0000516_abnormal_urinary_system	0.85285451
81	MP0005367_renal/urinary_system_phenotyp	0.85285451
82	MP0002064_seizures	0.84706174
83	MP0006292_abnormal_olfactory_placode	0.83252366
84	MP0001764_abnormal_homeostasis	0.83210242
85	MP0004019_abnormal_vitamin_homeostasis	0.82728169
86	MP0002184_abnormal_innervation	0.82358805
87	MP0005647_abnormal_sex_gland	0.81954456
88	MP0005248_abnormal_Harderian_gland	0.81936273
89	MP0000383_abnormal_hair_follicle	0.81136920
90	MP0001905_abnormal_dopamine_level	0.80504824
91	MP0003698_abnormal_male_reproductive	0.80093157
92	MP0000778_abnormal_nervous_system	0.79680290
93	MP0005391_vision/eye_phenotype	0.79530708
94	MP0002229_neurodegeneration	0.77650760
95	MP0001986_abnormal_taste_sensitivity	0.77486528
96	MP0004142_abnormal_muscle_tone	0.76628860
97	MP0003633_abnormal_nervous_system	0.76243128
98	MP0001529_abnormal_vocalization	0.75661844
99	MP0009780_abnormal_chondrocyte_physiolo	0.73931809
100	MP0003121_genomic_imprinting	0.73902313

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.32208754
2	Pancreatic fibrosis (HP:0100732)	4.09246133
3	True hermaphroditism (HP:0010459)	3.80485727
4	Molar tooth sign on MRI (HP:0002419)	3.70468574
5	Abnormality of midbrain morphology (HP:0002418)	3.70468574
6	Nephronophthisis (HP:0000090)	3.46855541
7	Hyperventilation (HP:0002883)	3.23851362
8	Abnormality of the renal cortex (HP:0011035)	3.21577896
9	Hypothermia (HP:0002045)	3.20337870
10	Type II lissencephaly (HP:0007260)	3.20232427
11	Hyperglycinuria (HP:0003108)	3.13613539
12	Abnormality of the renal medulla (HP:0100957)	3.08706431
13	Broad-based gait (HP:0002136)	3.06535315
14	Congenital stationary night blindness (HP:0007642)	3.05769595
15	Medial flaring of the eyebrow (HP:0010747)	2.94314793
16	Gaze-evoked nystagmus (HP:0000640)	2.86093971
17	Attenuation of retinal blood vessels (HP:0007843)	2.74511562
18	Chronic hepatic failure (HP:0100626)	2.60539475
19	Cystic liver disease (HP:0006706)	2.57177481
20	Abnormal drinking behavior (HP:0030082)	2.50739868
21	Polydipsia (HP:0001959)	2.50739868
22	Ketoacidosis (HP:0001993)	2.50476036
23	Abnormality of serine family amino acid metabolism (HP:0010894)	2.48155440
24	Abnormality of glycine metabolism (HP:0010895)	2.48155440
25	Gait imbalance (HP:0002141)	2.46159802
26	Tubular atrophy (HP:0000092)	2.46052263
27	Cerebellar dysplasia (HP:0007033)	2.41868912
28	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.40792115
29	Renal cortical cysts (HP:0000803)	2.36342008
30	Congenital primary aphakia (HP:0007707)	2.34723333
31	Decreased circulating renin level (HP:0003351)	2.32701357
32	Inability to walk (HP:0002540)	2.27625989
33	Sclerocornea (HP:0000647)	2.25077146
34	Abnormality of the nasal septum (HP:0000419)	2.24188527
35	Abnormality of the pons (HP:0007361)	2.21663379
36	Progressive inability to walk (HP:0002505)	2.21450269
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.20202142
38	Large for gestational age (HP:0001520)	2.19987543
39	Fibular aplasia (HP:0002990)	2.18499281
40	Hypoplasia of the pons (HP:0012110)	2.17783658
41	Abolished electroretinogram (ERG) (HP:0000550)	2.17423951
42	Ketosis (HP:0001946)	2.17388592
43	Genital tract atresia (HP:0001827)	2.16507582
44	Febrile seizures (HP:0002373)	2.15557331
45	Nephrogenic diabetes insipidus (HP:0009806)	2.13272337
46	Generalized hypopigmentation of hair (HP:0011358)	2.13042006
47	Pendular nystagmus (HP:0012043)	2.12966882
48	Fair hair (HP:0002286)	2.11049510
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10670291
50	Optic nerve hypoplasia (HP:0000609)	2.08365484
51	Methylmalonic acidemia (HP:0002912)	2.07846160
52	Abnormality of macular pigmentation (HP:0008002)	2.06275401
53	Postaxial foot polydactyly (HP:0001830)	2.04983056
54	Severe Myopia (HP:0011003)	2.03761418
55	Aplasia/hypoplasia of the uterus (HP:0008684)	2.03594510
56	Lissencephaly (HP:0001339)	2.03291705
57	Stomach cancer (HP:0012126)	2.02935238
58	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.02886052
59	Azoospermia (HP:0000027)	2.01950614
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01231720
61	Short tibia (HP:0005736)	2.00938325
62	Progressive cerebellar ataxia (HP:0002073)	2.00934734
63	Absent speech (HP:0001344)	2.00082447
64	Postaxial hand polydactyly (HP:0001162)	1.99644378
65	Vaginal atresia (HP:0000148)	1.98941238
66	Polyuria (HP:0000103)	1.97771379
67	Decreased central vision (HP:0007663)	1.97050740
68	Pachygyria (HP:0001302)	1.94714850
69	Increased corneal curvature (HP:0100692)	1.93886055
70	Keratoconus (HP:0000563)	1.93886055
71	Anencephaly (HP:0002323)	1.93750714
72	Intestinal atresia (HP:0011100)	1.92955467
73	Male pseudohermaphroditism (HP:0000037)	1.92248506
74	Absent/shortened dynein arms (HP:0200106)	1.91699828
75	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.91699828
76	Furrowed tongue (HP:0000221)	1.90670599
77	Bile duct proliferation (HP:0001408)	1.85004388
78	Abnormal biliary tract physiology (HP:0012439)	1.85004388
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.81707241
80	Congenital hepatic fibrosis (HP:0002612)	1.80707189
81	Colon cancer (HP:0003003)	1.80448205
82	Bilateral microphthalmos (HP:0007633)	1.80205820
83	Congenital, generalized hypertrichosis (HP:0004540)	1.79893983
84	Hypoplasia of the uterus (HP:0000013)	1.79240205
85	Tachypnea (HP:0002789)	1.79029014
86	Hyperglycinemia (HP:0002154)	1.78655046
87	Disproportionate short-trunk short stature (HP:0003521)	1.77341348
88	Acute encephalopathy (HP:0006846)	1.76294926
89	Amelogenesis imperfecta (HP:0000705)	1.76194300
90	Anterior segment dysgenesis (HP:0007700)	1.75898490
91	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.74983289
92	Acute necrotizing encephalopathy (HP:0006965)	1.72840501
93	Tented upper lip vermilion (HP:0010804)	1.72389144
94	Mitochondrial inheritance (HP:0001427)	1.67684890
95	Progressive macrocephaly (HP:0004481)	1.67526299
96	Hypomagnesemia (HP:0002917)	1.66356573
97	Increased CSF lactate (HP:0002490)	1.66005544
98	Abnormality of renal excretion (HP:0011036)	1.66002150
99	Hypoplasia of the ulna (HP:0003022)	1.65580937
100	Protruding tongue (HP:0010808)	1.64775402

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.59109479
2	AKT3	4.43725733
3	TAOK3	3.29400656
4	WNK3	3.09077898
5	MAP3K4	2.23866512
6	DAPK2	2.16396226
7	BMPR1B	2.16023259
8	CAMK1D	2.08725906
9	PINK1	2.05342267
10	ADRBK2	2.04464512
11	NUAK1	2.01007003
12	WNK4	1.97615473
13	GRK1	1.96193175
14	STK39	1.88847268
15	INSRR	1.82977534
16	ZAK	1.82063205
17	MAP4K2	1.75363393
18	TNIK	1.70839477
19	ERBB3	1.65869850
20	MAPK13	1.63738053
21	NME1	1.59693941
22	NTRK3	1.52282187
23	OXSR1	1.50112821
24	CAMK1G	1.48736879
25	SGK2	1.44220395
26	STK38L	1.38923644
27	ACVR1B	1.28811312
28	MARK1	1.21174632
29	BCR	1.17657089
30	CASK	1.16670692
31	TNK2	1.11383449
32	TLK1	1.10831102
33	MAP2K7	1.10172703
34	SGK223	1.09367961
35	SGK494	1.09367961
36	MKNK2	1.08645228
37	TXK	1.05493885
38	CAMKK2	0.96618822
39	TRIM28	0.92629086
40	LATS1	0.92252260
41	PAK3	0.85402618
42	DYRK2	0.81755456
43	PRKCE	0.80514703
44	FGFR2	0.78692678
45	ERBB2	0.77648858
46	EIF2AK3	0.76548973
47	MAPKAPK3	0.76063257
48	STK3	0.75940895
49	PHKG2	0.72482408
50	PHKG1	0.72482408
51	PRKAA2	0.71469225
52	ADRBK1	0.69949523
53	PRKCG	0.69822437
54	PNCK	0.69713136
55	PRKAA1	0.69498464
56	PIK3CA	0.67615562
57	SGK3	0.64828387
58	EIF2AK1	0.64211205
59	BRSK2	0.63970608
60	STK38	0.61115367
61	CSNK1G1	0.59165531
62	PLK2	0.59047390
63	MAP2K6	0.57035984
64	CSNK1G2	0.55503079
65	CSNK1A1L	0.54804558
66	PRKACA	0.53648185
67	FER	0.51137653
68	PLK3	0.51072984
69	MARK2	0.50662814
70	CAMK1	0.50325569
71	NLK	0.49738615
72	EIF2AK2	0.47398708
73	CSNK1A1	0.45551851
74	TEC	0.44498465
75	MKNK1	0.44213200
76	SGK1	0.42498430
77	WEE1	0.42480579
78	CSNK1D	0.42056648
79	PTK2B	0.40881985
80	MAPKAPK5	0.40081038
81	NTRK2	0.40015714
82	BCKDK	0.39834639
83	STK11	0.39799126
84	CAMK2A	0.38866589
85	VRK1	0.38758750
86	CSNK1G3	0.36599187
87	PRKCH	0.36416175
88	PRKCQ	0.36390957
89	TIE1	0.35800900
90	PLK4	0.33024816
91	PRKCA	0.32977454
92	ATM	0.32882866
93	SIK2	0.32118581
94	MAP2K2	0.31743716
95	PRKD3	0.31325191
96	TSSK6	0.30687586
97	CSNK1E	0.29263759
98	GRK5	0.28308102
99	IKBKB	0.28070467
100	PRKCZ	0.28003518

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.34821203
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.64241850
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.53861599
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.37832886
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27559976
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.27271312
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.19808607
8	Phototransduction_Homo sapiens_hsa04744	2.09050631
9	Propanoate metabolism_Homo sapiens_hsa00640	2.08441631
10	Selenocompound metabolism_Homo sapiens_hsa00450	1.95594268
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.92712558
12	ABC transporters_Homo sapiens_hsa02010	1.86980354
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.76031973
14	beta-Alanine metabolism_Homo sapiens_hsa00410	1.75738613
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.75729572
16	Basal transcription factors_Homo sapiens_hsa03022	1.75023351
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.72640355
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.71203059
19	Nicotine addiction_Homo sapiens_hsa05033	1.60268339
20	Protein export_Homo sapiens_hsa03060	1.60017947
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59595486
22	Olfactory transduction_Homo sapiens_hsa04740	1.52911124
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48135787
24	Homologous recombination_Homo sapiens_hsa03440	1.47668257
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.46442269
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.44007684
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.42941642
28	One carbon pool by folate_Homo sapiens_hsa00670	1.41945276
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.40989611
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.40417073
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.40053407
32	Retinol metabolism_Homo sapiens_hsa00830	1.25876417
33	RNA polymerase_Homo sapiens_hsa03020	1.24480534
34	Peroxisome_Homo sapiens_hsa04146	1.21521984
35	Insulin secretion_Homo sapiens_hsa04911	1.19847593
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.15004926
37	Taste transduction_Homo sapiens_hsa04742	1.13712749
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.11828946
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11368490
40	Morphine addiction_Homo sapiens_hsa05032	1.10958107
41	RNA degradation_Homo sapiens_hsa03018	1.09817896
42	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.07099069
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06881226
44	Regulation of autophagy_Homo sapiens_hsa04140	1.06844062
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06316074
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04589374
47	Caffeine metabolism_Homo sapiens_hsa00232	1.04446545
48	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.04076967
49	Bile secretion_Homo sapiens_hsa04976	1.00260088
50	Histidine metabolism_Homo sapiens_hsa00340	1.00255398
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97863923
52	Parkinsons disease_Homo sapiens_hsa05012	0.97132003
53	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.95793782
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.95649105
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.95174277
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93789400
57	Mineral absorption_Homo sapiens_hsa04978	0.91811593
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.91715062
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84067213
60	Fatty acid degradation_Homo sapiens_hsa00071	0.83639737
61	Huntingtons disease_Homo sapiens_hsa05016	0.83439082
62	Serotonergic synapse_Homo sapiens_hsa04726	0.83172670
63	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.79758731
64	GABAergic synapse_Homo sapiens_hsa04727	0.78497220
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78288068
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.78258459
67	Circadian rhythm_Homo sapiens_hsa04710	0.78214515
68	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.77053171
69	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76731938
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74356313
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.73363412
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.72124963
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.71328270
74	Circadian entrainment_Homo sapiens_hsa04713	0.70650398
75	Purine metabolism_Homo sapiens_hsa00230	0.70575246
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.66059395
77	Metabolic pathways_Homo sapiens_hsa01100	0.64854059
78	Lysine degradation_Homo sapiens_hsa00310	0.62938727
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62608036
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.62313895
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.60944221
82	Sulfur metabolism_Homo sapiens_hsa00920	0.57124698
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57030955
84	Salivary secretion_Homo sapiens_hsa04970	0.56748210
85	Cocaine addiction_Homo sapiens_hsa05030	0.56575467
86	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.54403982
87	Alzheimers disease_Homo sapiens_hsa05010	0.52987847
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52324691
89	Glutathione metabolism_Homo sapiens_hsa00480	0.51520491
90	Fatty acid elongation_Homo sapiens_hsa00062	0.50155375
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.50106549
92	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.50047979
93	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.49617375
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.47597132
95	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.44898579
96	Cardiac muscle contraction_Homo sapiens_hsa04260	0.43999163
97	Amphetamine addiction_Homo sapiens_hsa05031	0.43946259
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.42244883
99	Long-term depression_Homo sapiens_hsa04730	0.41114478
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.41048430

CYP4F62P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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