CYP4F8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033397.09187027
2nephron tubule formation (GO:0072079)5.85973451
3reproduction (GO:0000003)5.42662082
4pattern specification involved in kidney development (GO:0061004)5.39394777
5collecting duct development (GO:0072044)5.29270050
6regulation of hippo signaling (GO:0035330)5.22964164
7mesonephros development (GO:0001823)5.14084752
8negative regulation of metanephros development (GO:0072217)5.10954028
9urogenital system development (GO:0001655)5.02387431
10regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.96547093
11negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.95218836
12mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.90301980
13metanephric nephron tubule development (GO:0072234)4.74095335
14metanephric tubule development (GO:0072170)4.74095335
15maintenance of gastrointestinal epithelium (GO:0030277)4.35589805
16regulation of mesenchymal cell apoptotic process (GO:2001053)4.18358202
17metanephric nephron epithelium development (GO:0072243)4.06052552
18regulation of apoptotic process involved in morphogenesis (GO:1902337)3.96941237
19metanephric epithelium development (GO:0072207)3.74235594
20behavioral response to nicotine (GO:0035095)3.72961777
21endocrine hormone secretion (GO:0060986)3.71879258
22sodium-independent organic anion transport (GO:0043252)3.62594002
23cell differentiation involved in metanephros development (GO:0072202)3.58211051
24positive regulation of digestive system process (GO:0060456)3.51145322
25positive regulation of glomerulus development (GO:0090193)3.46828311
26specification of organ identity (GO:0010092)3.45410246
27negative regulation of kidney development (GO:0090185)3.38092591
28urinary tract smooth muscle contraction (GO:0014848)3.37329647
29embryonic epithelial tube formation (GO:0001838)3.35922205
30positive regulation of action potential (GO:0045760)3.33595071
31nephron tubule development (GO:0072080)3.25515220
32positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.24442184
33positive regulation of metanephros development (GO:0072216)3.21643661
34fucose catabolic process (GO:0019317)3.15812776
35L-fucose metabolic process (GO:0042354)3.15812776
36L-fucose catabolic process (GO:0042355)3.15812776
37smooth muscle contraction (GO:0006939)3.15430134
38indole-containing compound catabolic process (GO:0042436)3.15297432
39indolalkylamine catabolic process (GO:0046218)3.15297432
40tryptophan catabolic process (GO:0006569)3.15297432
41regulation of acrosome reaction (GO:0060046)3.15232552
42positive regulation of fatty acid transport (GO:2000193)3.14657184
43epithelial tube formation (GO:0072175)3.13465972
44cardiovascular system development (GO:0072358)3.10300299
45cranial nerve structural organization (GO:0021604)3.09335607
46fibroblast migration (GO:0010761)3.06777865
47epithelial structure maintenance (GO:0010669)3.05130531
48negative regulation of reactive oxygen species metabolic process (GO:2000378)3.01965475
49regulation of action potential (GO:0098900)3.00585243
50regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.98442345
51renal tubule development (GO:0061326)2.98335842
52cellular ketone body metabolic process (GO:0046950)2.94704379
53positive regulation of fatty acid oxidation (GO:0046321)2.92623605
54indolalkylamine metabolic process (GO:0006586)2.92326229
55regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.91709348
56kynurenine metabolic process (GO:0070189)2.89819032
57mesenchymal to epithelial transition (GO:0060231)2.87509304
58regulation of fatty acid oxidation (GO:0046320)2.86816068
59mesenchymal cell differentiation involved in kidney development (GO:0072161)2.86276473
60mesenchymal cell differentiation involved in renal system development (GO:2001012)2.86276473
61cellular response to ATP (GO:0071318)2.85992785
62axoneme assembly (GO:0035082)2.82927477
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.80203680
64negative regulation of translation, ncRNA-mediated (GO:0040033)2.80203680
65regulation of translation, ncRNA-mediated (GO:0045974)2.80203680
66regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.77446439
67organic cation transport (GO:0015695)2.71006696
68ketone body metabolic process (GO:1902224)2.69579186
69regulation of stem cell maintenance (GO:2000036)2.68295321
70DNA deamination (GO:0045006)2.67946266
71positive regulation of sodium ion transmembrane transport (GO:1902307)2.67686303
72regulation of acyl-CoA biosynthetic process (GO:0050812)2.63337590
73fatty acid derivative transport (GO:1901571)2.61792051
74icosanoid transport (GO:0071715)2.61792051
75positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.61166266
76cranial nerve morphogenesis (GO:0021602)2.60929179
77anterior/posterior axis specification, embryo (GO:0008595)2.59983673
78tryptophan metabolic process (GO:0006568)2.59603634
79nephron tubule morphogenesis (GO:0072078)2.58700918
80nephron epithelium morphogenesis (GO:0072088)2.58700918
81tonic smooth muscle contraction (GO:0014820)2.56203192
82cornea development in camera-type eye (GO:0061303)2.56156292
83brain morphogenesis (GO:0048854)2.55761436
84establishment of protein localization to Golgi (GO:0072600)2.52727570
85response to pheromone (GO:0019236)2.52724824
86transcytosis (GO:0045056)2.51462203
87detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.49746551
88cochlea development (GO:0090102)2.49075916
89coenzyme catabolic process (GO:0009109)2.48332044
90polarized epithelial cell differentiation (GO:0030859)2.46419158
91detection of light stimulus involved in sensory perception (GO:0050962)2.46112409
92detection of light stimulus involved in visual perception (GO:0050908)2.46112409
93epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44218870
94metanephric mesenchyme development (GO:0072075)2.42077905
95nephron epithelium development (GO:0072009)2.40297757
96benzene-containing compound metabolic process (GO:0042537)2.39451138
97reflex (GO:0060004)2.38710667
98atrial cardiac muscle cell action potential (GO:0086014)2.38401536
99positive regulation of heat generation (GO:0031652)2.38383559
100sexual reproduction (GO:0019953)15.1740112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.37610862
2EZH2_22144423_ChIP-Seq_EOC_Human3.35789200
3ZNF274_21170338_ChIP-Seq_K562_Hela2.92936409
4GBX2_23144817_ChIP-Seq_PC3_Human2.52835353
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33134727
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13769800
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04484769
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01662587
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01498822
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91584950
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90169534
12FLI1_27457419_Chip-Seq_LIVER_Mouse1.85083463
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69920666
14STAT3_23295773_ChIP-Seq_U87_Human1.68687527
15AR_25329375_ChIP-Seq_VCAP_Human1.66001383
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.65541583
17ER_23166858_ChIP-Seq_MCF-7_Human1.64471812
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62529666
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60361133
20SMAD4_21799915_ChIP-Seq_A2780_Human1.59451362
21DROSHA_22980978_ChIP-Seq_HELA_Human1.57534243
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57479505
23P300_19829295_ChIP-Seq_ESCs_Human1.56595123
24IGF1R_20145208_ChIP-Seq_DFB_Human1.56269690
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55670250
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.55524980
27RUNX2_22187159_ChIP-Seq_PCA_Human1.53606943
28AHR_22903824_ChIP-Seq_MCF-7_Human1.52363144
29TCF4_23295773_ChIP-Seq_U87_Human1.51441514
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51251081
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51019728
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50026893
33IRF1_19129219_ChIP-ChIP_H3396_Human1.41821626
34TAF15_26573619_Chip-Seq_HEK293_Human1.41689873
35FUS_26573619_Chip-Seq_HEK293_Human1.40667510
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40502336
37ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38588753
38CDX2_22108803_ChIP-Seq_LS180_Human1.38538726
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37090060
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37090060
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36900743
42AR_21572438_ChIP-Seq_LNCaP_Human1.36646165
43TP53_16413492_ChIP-PET_HCT116_Human1.36605222
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36249214
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35271719
46CBP_20019798_ChIP-Seq_JUKART_Human1.35271719
47BCAT_22108803_ChIP-Seq_LS180_Human1.34544215
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33244594
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33186221
50TCF4_22108803_ChIP-Seq_LS180_Human1.30567571
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.29484717
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26541629
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.26320879
54SMAD3_21741376_ChIP-Seq_HESCs_Human1.25405333
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.23879148
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23708116
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22996584
58SOX2_19829295_ChIP-Seq_ESCs_Human1.20888399
59NANOG_19829295_ChIP-Seq_ESCs_Human1.20888399
60GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.19940803
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.19662085
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18301847
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17220845
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17142185
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.16683496
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16384524
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14668030
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13028790
69RNF2_27304074_Chip-Seq_NSC_Mouse1.12572412
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12500875
71EWS_26573619_Chip-Seq_HEK293_Human1.12484581
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.12460315
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12014599
74REST_21632747_ChIP-Seq_MESCs_Mouse1.11298089
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.10379411
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08576069
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08318995
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.07560946
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.07269844
80* HOXB7_26014856_ChIP-Seq_BT474_Human1.07175517
81AR_20517297_ChIP-Seq_VCAP_Human1.05953407
82SMAD4_21741376_ChIP-Seq_HESCs_Human1.05873392
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.04877733
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03592635
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03376947
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.03376947
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02712473
88OCT1_27270436_Chip-Seq_PROSTATE_Human1.02685099
89KDM2B_26808549_Chip-Seq_REH_Human1.00181719
90* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99144918
91CEBPB_22108803_ChIP-Seq_LS180_Human0.97262146
92WDR5_24793694_ChIP-Seq_LNCAP_Human0.97159738
93EZH2_27294783_Chip-Seq_ESCs_Mouse0.96833487
94* GATA3_21878914_ChIP-Seq_MCF-7_Human0.96447071
95NCOR_22424771_ChIP-Seq_293T_Human0.96257529
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.95928589
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.95768506
98SOX2_21211035_ChIP-Seq_LN229_Gbm0.94903086
99OCT4_20526341_ChIP-Seq_ESCs_Human0.94791617
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.94305648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder4.59759400
2MP0002653_abnormal_ependyma_morphology3.76940305
3MP0002876_abnormal_thyroid_physiology3.32691233
4MP0005670_abnormal_white_adipose3.08622663
5MP0005646_abnormal_pituitary_gland2.79174337
6MP0002638_abnormal_pupillary_reflex2.62596222
7MP0001501_abnormal_sleep_pattern2.46448365
8MP0003195_calcinosis2.37492283
9MP0000538_abnormal_urinary_bladder2.24691708
10MP0001968_abnormal_touch/_nociception2.20817559
11MP0002837_dystrophic_cardiac_calcinosis2.17261623
12MP0005551_abnormal_eye_electrophysiolog2.00553185
13MP0008875_abnormal_xenobiotic_pharmacok2.00486812
14MP0001756_abnormal_urination1.96302884
15MP0000427_abnormal_hair_cycle1.91930543
16MP0002282_abnormal_trachea_morphology1.84760780
17MP0008004_abnormal_stomach_pH1.83827499
18MP0000631_abnormal_neuroendocrine_gland1.83112827
19MP0004145_abnormal_muscle_electrophysio1.76539041
20MP0001984_abnormal_olfaction1.75610455
21MP0001664_abnormal_digestion1.75422200
22MP0003879_abnormal_hair_cell1.74943053
23MP0008872_abnormal_physiological_respon1.70780293
24MP0003938_abnormal_ear_development1.62922322
25MP0001485_abnormal_pinna_reflex1.60294668
26MP0008877_abnormal_DNA_methylation1.59501362
27MP0004043_abnormal_pH_regulation1.59115045
28MP0005360_urolithiasis1.59014761
29MP0000383_abnormal_hair_follicle1.55423473
30MP0000566_synostosis1.52120352
31MP0005645_abnormal_hypothalamus_physiol1.52106013
32MP0003646_muscle_fatigue1.51677539
33MP0002736_abnormal_nociception_after1.47649954
34MP0000230_abnormal_systemic_arterial1.45934691
35MP0002138_abnormal_hepatobiliary_system1.44786761
36MP0000516_abnormal_urinary_system1.44659487
37MP0005367_renal/urinary_system_phenotyp1.44659487
38MP0003136_yellow_coat_color1.43037275
39MP0000372_irregular_coat_pigmentation1.38972705
40MP0008961_abnormal_basal_metabolism1.37016763
41MP0001502_abnormal_circadian_rhythm1.35901759
42MP0009745_abnormal_behavioral_response1.35803525
43MP0001919_abnormal_reproductive_system1.31823538
44MP0000534_abnormal_ureter_morphology1.31616682
45MP0004885_abnormal_endolymph1.31197689
46MP0002272_abnormal_nervous_system1.27368912
47MP0006072_abnormal_retinal_apoptosis1.26018479
48MP0005253_abnormal_eye_physiology1.25858234
49MP0003045_fibrosis1.23217424
50MP0003787_abnormal_imprinting1.22178353
51MP0000569_abnormal_digit_pigmentation1.20039116
52MP0009046_muscle_twitch1.11079966
53MP0002102_abnormal_ear_morphology1.09369009
54MP0009780_abnormal_chondrocyte_physiolo1.08273920
55MP0005389_reproductive_system_phenotype1.07655965
56MP0001486_abnormal_startle_reflex1.05735031
57MP0000647_abnormal_sebaceous_gland1.02927586
58MP0005332_abnormal_amino_acid1.01127458
59MP0000026_abnormal_inner_ear0.99956334
60MP0001270_distended_abdomen0.98125925
61MP0003936_abnormal_reproductive_system0.98088205
62MP0000013_abnormal_adipose_tissue0.96556652
63MP0001986_abnormal_taste_sensitivity0.95564992
64MP0005085_abnormal_gallbladder_physiolo0.95527165
65MP0002735_abnormal_chemical_nociception0.93242212
66MP0004147_increased_porphyrin_level0.92835045
67MP0001970_abnormal_pain_threshold0.90189124
68MP0004133_heterotaxia0.87091627
69MP0002572_abnormal_emotion/affect_behav0.86945732
70MP0001963_abnormal_hearing_physiology0.86787862
71MP0005075_abnormal_melanosome_morpholog0.86762979
72MP0002067_abnormal_sensory_capabilities0.86350582
73MP0000049_abnormal_middle_ear0.85753279
74MP0002733_abnormal_thermal_nociception0.85623081
75MP0002928_abnormal_bile_duct0.84347383
76MP0002938_white_spotting0.84089736
77MP0002160_abnormal_reproductive_system0.83813549
78MP0004142_abnormal_muscle_tone0.83461091
79MP0002693_abnormal_pancreas_physiology0.81641890
80MP0005174_abnormal_tail_pigmentation0.81458680
81MP0004036_abnormal_muscle_relaxation0.81137094
82MP0002557_abnormal_social/conspecific_i0.80576955
83MP0002064_seizures0.80564874
84MP0000778_abnormal_nervous_system0.80462391
85MP0003953_abnormal_hormone_level0.80295195
86MP0005386_behavior/neurological_phenoty0.80285602
87MP0004924_abnormal_behavior0.80285602
88MP0004742_abnormal_vestibular_system0.80048020
89MP0002277_abnormal_respiratory_mucosa0.79338700
90MP0003950_abnormal_plasma_membrane0.78412117
91MP0001944_abnormal_pancreas_morphology0.77967544
92MP0003137_abnormal_impulse_conducting0.77836163
93MP0004381_abnormal_hair_follicle0.77134043
94MP0002254_reproductive_system_inflammat0.76506580
95MP0004130_abnormal_muscle_cell0.74141866
96MP0002168_other_aberrant_phenotype0.73342335
97MP0010678_abnormal_skin_adnexa0.72547321
98MP0002229_neurodegeneration0.71761367
99MP0001324_abnormal_eye_pigmentation0.71330215
100MP0005620_abnormal_muscle_contractility0.71238873

Predicted human phenotypes

RankGene SetZ-score
1Progressive cerebellar ataxia (HP:0002073)6.09775858
2Abnormality of secondary sexual hair (HP:0009888)4.22440177
3Abnormality of the axillary hair (HP:0100134)4.22440177
4Hypothermia (HP:0002045)4.12969837
5Pancreatic cysts (HP:0001737)4.09262338
6Thyroid-stimulating hormone excess (HP:0002925)3.88801289
7Shawl scrotum (HP:0000049)3.77255914
8Genetic anticipation (HP:0003743)3.60796842
9Pancreatic fibrosis (HP:0100732)3.58976187
10Hyperventilation (HP:0002883)3.55459977
11True hermaphroditism (HP:0010459)3.34346795
12Decreased circulating renin level (HP:0003351)3.29904089
13Molar tooth sign on MRI (HP:0002419)3.26527244
14Abnormality of midbrain morphology (HP:0002418)3.26527244
15Polydipsia (HP:0001959)3.16073235
16Abnormal drinking behavior (HP:0030082)3.16073235
17Cerebral palsy (HP:0100021)3.06417231
18Nephronophthisis (HP:0000090)3.05974059
19Gaze-evoked nystagmus (HP:0000640)3.01579997
20Potter facies (HP:0002009)3.00482111
21Facial shape deformation (HP:0011334)3.00482111
22Chorioretinal atrophy (HP:0000533)2.99959193
23Abnormality of macular pigmentation (HP:0008002)2.89469784
24Abnormality of the renal medulla (HP:0100957)2.85898553
25Hypoplastic nipples (HP:0002557)2.81397903
26Congenital stationary night blindness (HP:0007642)2.81154141
27Aortic aneurysm (HP:0004942)2.80822270
28Chronic hepatic failure (HP:0100626)2.79785955
29Abnormality of the renal cortex (HP:0011035)2.79208669
30Clubbing of toes (HP:0100760)2.78781054
31Cystic liver disease (HP:0006706)2.71665806
32Large for gestational age (HP:0001520)2.63406898
33Medial flaring of the eyebrow (HP:0010747)2.53913772
34Genital tract atresia (HP:0001827)2.53625056
35Protruding tongue (HP:0010808)2.52226025
36Vaginal atresia (HP:0000148)2.50258434
37Aplasia of the musculature (HP:0100854)2.48415914
38Broad-based gait (HP:0002136)2.45363128
39Tubular atrophy (HP:0000092)2.45053714
40Type II lissencephaly (HP:0007260)2.45011616
41Clumsiness (HP:0002312)2.44881069
42Prolonged QT interval (HP:0001657)2.41000209
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.40827609
44Fair hair (HP:0002286)2.34850058
45Congenital sensorineural hearing impairment (HP:0008527)2.34622656
46Polyuria (HP:0000103)2.29072451
47Nephrogenic diabetes insipidus (HP:0009806)2.26525329
48Breast hypoplasia (HP:0003187)2.24528710
49Hypoplasia of the ulna (HP:0003022)2.22103367
50Attenuation of retinal blood vessels (HP:0007843)2.21461444
51Aplasia/Hypoplasia involving the musculature (HP:0001460)2.20063501
52Sparse lateral eyebrow (HP:0005338)2.17039289
53Abnormality of alanine metabolism (HP:0010916)2.16990903
54Hyperalaninemia (HP:0003348)2.16990903
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16990903
56Macroglossia (HP:0000158)2.12423762
57Abnormality of renin-angiotensin system (HP:0000847)2.11814143
58Abolished electroretinogram (ERG) (HP:0000550)2.10409161
59Patellar aplasia (HP:0006443)2.10009465
60Hyperpituitarism (HP:0010514)2.09058042
61Hypoplastic labia majora (HP:0000059)2.06250944
62Neoplasm of the heart (HP:0100544)2.06181672
63Aplasia/Hypoplasia of the ulna (HP:0006495)2.02529510
64Gait imbalance (HP:0002141)2.02032906
65Renal dysplasia (HP:0000110)2.00748056
66Optic nerve coloboma (HP:0000588)1.98701004
67Hyperaldosteronism (HP:0000859)1.94027033
68Bicornuate uterus (HP:0000813)1.94024695
69Macular degeneration (HP:0000608)1.93222256
70Aplasia/Hypoplasia of the patella (HP:0006498)1.92983064
71Congenital primary aphakia (HP:0007707)1.92807368
72Absent speech (HP:0001344)1.91582862
73Absent radius (HP:0003974)1.90352470
74Aplasia involving forearm bones (HP:0009822)1.90075027
75Absent forearm bone (HP:0003953)1.90075027
76Widely spaced teeth (HP:0000687)1.89951481
77Furrowed tongue (HP:0000221)1.88067290
78Inability to walk (HP:0002540)1.87923321
79Pigmentary retinal degeneration (HP:0001146)1.87780961
80Abnormality of the nasal septum (HP:0000419)1.87686361
81Generalized hypopigmentation of hair (HP:0011358)1.85344486
82Morphological abnormality of the pyramidal tract (HP:0002062)1.84923514
83Bronchomalacia (HP:0002780)1.84598362
84Abnormality of the labia majora (HP:0012881)1.83496566
85Progressive inability to walk (HP:0002505)1.81832420
86Cerebellar dysplasia (HP:0007033)1.81732974
87Postaxial hand polydactyly (HP:0001162)1.79905364
88Bile duct proliferation (HP:0001408)1.79229186
89Abnormal biliary tract physiology (HP:0012439)1.79229186
90Abnormal urine output (HP:0012590)1.78504920
91Duplicated collecting system (HP:0000081)1.75301060
92Ketosis (HP:0001946)1.74120308
93Poor coordination (HP:0002370)1.72564412
94Abnormality of the renal collecting system (HP:0004742)1.72247687
95Conical tooth (HP:0000698)1.72104421
96Febrile seizures (HP:0002373)1.71795320
97Short tibia (HP:0005736)1.71631767
98Aplasia/Hypoplasia of the tongue (HP:0010295)1.70861273
99Congenital, generalized hypertrichosis (HP:0004540)1.68617174
100Congenital hepatic fibrosis (HP:0002612)1.67911590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT38.11743958
2FRK5.70952132
3PIK3CG4.77211526
4MYLK3.35129814
5BMPR1B3.01398315
6TAOK32.79681640
7ACVR1B2.43476160
8ADRBK22.29276913
9WNK31.70079512
10NUAK11.66830754
11GRK11.58519833
12PAK31.57318958
13INSRR1.54313224
14MAPK131.46021620
15TNK21.44465057
16PIK3CA1.42688124
17MAP4K21.41812485
18DMPK1.29362580
19WNK41.28133106
20TGFBR11.27691364
21MAPKAPK31.21284207
22CAMK1D1.20398365
23PINK11.19723016
24ZAK1.17272002
25TNIK1.13310621
26CAMK1G1.07239267
27MARK11.06560957
28TXK1.00413787
29DAPK20.99536038
30STK38L0.95437382
31LATS10.91593081
32FGFR20.87687447
33MAP3K40.86356419
34ADRBK10.85362552
35TLK10.84654540
36NLK0.83456878
37MKNK20.82906404
38MAPKAPK50.79247642
39CHUK0.78022132
40MAP2K60.75420184
41FER0.75148205
42PRKAA20.73191209
43STK390.72667065
44OXSR10.72118460
45MAP3K70.72057838
46PAK20.71865890
47CAMK10.70957533
48CASK0.70810056
49PRKCE0.63633484
50NME10.61300322
51IKBKB0.57167648
52STK380.56774732
53PTK2B0.52285468
54CDC42BPA0.52163182
55PRKAA10.51281676
56CAMKK20.51178554
57BCR0.47117430
58HIPK20.46457493
59PHKG20.46199052
60PHKG10.46199052
61PNCK0.45514359
62MAP2K10.44890717
63RPS6KA50.44783257
64NTRK30.44671686
65STK30.44511743
66TRPM70.42718975
67PRKCG0.41482128
68SGK20.40450845
69CSNK1A10.40439158
70STK110.40267316
71TEC0.39246722
72MAP2K20.38895322
73ROCK10.38541436
74CAMK40.37165871
75SIK20.36178596
76PRKCZ0.35357982
77MAP2K70.35213313
78PRKACA0.34699672
79IRAK10.34636290
80TRIM280.34480037
81PRKCI0.33056668
82MARK20.33023242
83RPS6KA60.32453463
84MAPK80.32242940
85MAPK10.31268967
86MKNK10.30600511
87CSNK1A1L0.30389161
88PRKACB0.29582252
89CAMK2A0.29260773
90PRKG10.27608248
91TIE10.27466604
92PRKCH0.26244417
93IGF1R0.25198740
94PRKCQ0.25008590
95EPHA30.24137387
96MAPK30.22950289
97PRKCA0.22630054
98CSNK1G10.21723815
99GSK3B0.21391235
100CSNK1D0.21313377

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.34134841
2Linoleic acid metabolism_Homo sapiens_hsa005912.82743539
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.70129488
4Phototransduction_Homo sapiens_hsa047442.54824143
5Butanoate metabolism_Homo sapiens_hsa006502.10073401
6Fatty acid biosynthesis_Homo sapiens_hsa000612.09337892
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07855753
8Vascular smooth muscle contraction_Homo sapiens_hsa042702.04773276
9Nitrogen metabolism_Homo sapiens_hsa009102.02836990
10Ether lipid metabolism_Homo sapiens_hsa005651.94691387
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88161588
12Circadian rhythm_Homo sapiens_hsa047101.84724487
13Taste transduction_Homo sapiens_hsa047421.83784844
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.81758147
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79825437
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78395463
17Tryptophan metabolism_Homo sapiens_hsa003801.70275569
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68123055
19Nicotine addiction_Homo sapiens_hsa050331.68084135
20Insulin secretion_Homo sapiens_hsa049111.65149717
21Propanoate metabolism_Homo sapiens_hsa006401.59329084
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54985164
23Selenocompound metabolism_Homo sapiens_hsa004501.54917566
24ABC transporters_Homo sapiens_hsa020101.45950481
25Circadian entrainment_Homo sapiens_hsa047131.43696936
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42028094
27Peroxisome_Homo sapiens_hsa041461.41694569
28Chemical carcinogenesis_Homo sapiens_hsa052041.40743132
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39609909
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.34714281
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34371097
32Ovarian steroidogenesis_Homo sapiens_hsa049131.32300301
33Caffeine metabolism_Homo sapiens_hsa002321.28354667
34* Arachidonic acid metabolism_Homo sapiens_hsa005901.27374817
35beta-Alanine metabolism_Homo sapiens_hsa004101.27345480
36Morphine addiction_Homo sapiens_hsa050321.26653114
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.26379774
38Salivary secretion_Homo sapiens_hsa049701.25591015
39Serotonergic synapse_Homo sapiens_hsa047261.23084160
40Basal transcription factors_Homo sapiens_hsa030221.13813391
41Gastric acid secretion_Homo sapiens_hsa049711.13258516
42Olfactory transduction_Homo sapiens_hsa047401.12621984
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12193349
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09959416
45Histidine metabolism_Homo sapiens_hsa003401.09690549
46Retinol metabolism_Homo sapiens_hsa008301.05437569
47Calcium signaling pathway_Homo sapiens_hsa040201.01730356
48Dorso-ventral axis formation_Homo sapiens_hsa043201.00176199
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98267897
50Protein export_Homo sapiens_hsa030600.96379538
51Lysine degradation_Homo sapiens_hsa003100.91980450
52Glutamatergic synapse_Homo sapiens_hsa047240.91884296
53Glycerolipid metabolism_Homo sapiens_hsa005610.87616634
54Pancreatic secretion_Homo sapiens_hsa049720.87607574
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87502651
56Oxidative phosphorylation_Homo sapiens_hsa001900.86980078
57Oxytocin signaling pathway_Homo sapiens_hsa049210.86942419
58GABAergic synapse_Homo sapiens_hsa047270.81371654
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.80786773
60Fatty acid metabolism_Homo sapiens_hsa012120.78525184
61Fanconi anemia pathway_Homo sapiens_hsa034600.76059594
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75878592
63Thyroid hormone synthesis_Homo sapiens_hsa049180.75648688
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75273898
65RNA polymerase_Homo sapiens_hsa030200.74765573
66Homologous recombination_Homo sapiens_hsa034400.73142010
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71508912
68Cholinergic synapse_Homo sapiens_hsa047250.69935946
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69384512
70Regulation of autophagy_Homo sapiens_hsa041400.68465715
71Renin secretion_Homo sapiens_hsa049240.67904092
72Dopaminergic synapse_Homo sapiens_hsa047280.66411102
73Long-term depression_Homo sapiens_hsa047300.63658416
74Cardiac muscle contraction_Homo sapiens_hsa042600.59405925
75Fatty acid degradation_Homo sapiens_hsa000710.57412167
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56317401
77PPAR signaling pathway_Homo sapiens_hsa033200.56255918
78RNA degradation_Homo sapiens_hsa030180.55029365
79One carbon pool by folate_Homo sapiens_hsa006700.54674858
80cAMP signaling pathway_Homo sapiens_hsa040240.54018471
81Fat digestion and absorption_Homo sapiens_hsa049750.53666980
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53619606
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50849564
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48322315
85Collecting duct acid secretion_Homo sapiens_hsa049660.45624202
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43833824
87Mineral absorption_Homo sapiens_hsa049780.43149494
88Amphetamine addiction_Homo sapiens_hsa050310.42495095
89Cocaine addiction_Homo sapiens_hsa050300.41568708
90Sulfur metabolism_Homo sapiens_hsa009200.40592739
91Huntingtons disease_Homo sapiens_hsa050160.37500029
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35348070
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.34738237
94Protein digestion and absorption_Homo sapiens_hsa049740.34053778
95* Metabolic pathways_Homo sapiens_hsa011000.32524197
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32298917
97Parkinsons disease_Homo sapiens_hsa050120.31784060
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31126973
99Tight junction_Homo sapiens_hsa045300.30973306
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30960902

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