CYP4X1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.11732222
2motile cilium assembly (GO:0044458)8.31392003
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.01099820
4epithelial cilium movement (GO:0003351)7.41894675
5axoneme assembly (GO:0035082)5.86419229
6regulation of cilium movement (GO:0003352)5.36835422
7left/right pattern formation (GO:0060972)5.31708386
8neuron cell-cell adhesion (GO:0007158)4.84483992
9primary alcohol catabolic process (GO:0034310)4.74996669
10presynaptic membrane assembly (GO:0097105)4.54414572
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.37226713
12postsynaptic membrane organization (GO:0001941)4.29790972
13presynaptic membrane organization (GO:0097090)4.19103134
14left/right axis specification (GO:0070986)4.18821790
15ethanol metabolic process (GO:0006067)4.07974226
16vitamin transmembrane transport (GO:0035461)3.98606284
17positive regulation of synapse assembly (GO:0051965)3.92973766
18ventricular system development (GO:0021591)3.92308445
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.92083647
20protein localization to synapse (GO:0035418)3.89169896
21microtubule bundle formation (GO:0001578)3.85066731
22glutamate receptor signaling pathway (GO:0007215)3.83188439
23positive regulation of dendritic spine morphogenesis (GO:0061003)3.77277246
24one-carbon compound transport (GO:0019755)3.75397590
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68942157
26regulation of microtubule-based movement (GO:0060632)3.68653304
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.67745925
28diterpenoid biosynthetic process (GO:0016102)3.65895085
29startle response (GO:0001964)3.62727854
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.61071797
31regulation of glutamate receptor signaling pathway (GO:1900449)3.57453405
32transmission of nerve impulse (GO:0019226)3.56559205
33intraciliary transport (GO:0042073)3.51992849
34vocalization behavior (GO:0071625)3.51588360
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.51338206
36righting reflex (GO:0060013)3.50059668
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.49866301
38regulation of interleukin-5 production (GO:0032674)3.46831309
39cilium organization (GO:0044782)3.44571819
40regulation of synapse assembly (GO:0051963)3.43589193
41neuron recognition (GO:0008038)3.39554925
42glutamate secretion (GO:0014047)3.37802530
43regulation of interleukin-13 production (GO:0032656)3.36781538
44cilium assembly (GO:0042384)3.35231122
45sodium ion homeostasis (GO:0055078)3.34197534
46synaptic transmission, glutamatergic (GO:0035249)3.33823837
47apical protein localization (GO:0045176)3.32335380
48regulation of short-term neuronal synaptic plasticity (GO:0048172)3.30258362
49axonal fasciculation (GO:0007413)3.26875169
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.23306062
51microtubule-based movement (GO:0007018)3.22228444
52neuron-neuron synaptic transmission (GO:0007270)3.21448102
53cerebral cortex radially oriented cell migration (GO:0021799)3.20923084
54G-protein coupled receptor internalization (GO:0002031)3.16268922
55ethanol oxidation (GO:0006069)3.15052142
56lung epithelium development (GO:0060428)3.14081704
57positive regulation of dendritic spine development (GO:0060999)3.11787867
58response to xenobiotic stimulus (GO:0009410)3.10344238
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07104670
60central nervous system projection neuron axonogenesis (GO:0021952)3.05250643
61long-chain fatty acid biosynthetic process (GO:0042759)3.03199637
62positive regulation of action potential (GO:0045760)3.02336987
63negative regulation of inclusion body assembly (GO:0090084)2.99428651
64response to pheromone (GO:0019236)2.99427400
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98891208
66aldehyde catabolic process (GO:0046185)2.97786156
67regulation of postsynaptic membrane potential (GO:0060078)2.97589854
68regulation of synaptic vesicle exocytosis (GO:2000300)2.95590968
69positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95526504
70opioid receptor signaling pathway (GO:0038003)2.92174638
71neuronal action potential propagation (GO:0019227)2.91042163
72urinary tract smooth muscle contraction (GO:0014848)2.90950006
73regulation of respiratory system process (GO:0044065)2.90845144
74synaptic vesicle maturation (GO:0016188)2.88423474
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87454010
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.83561126
77limb bud formation (GO:0060174)2.81260880
78regulation of synaptic transmission, glutamatergic (GO:0051966)2.80957812
79protein localization to cilium (GO:0061512)2.80572189
80positive regulation of protein homodimerization activity (GO:0090073)2.80194326
81inner ear receptor stereocilium organization (GO:0060122)2.79205235
82regulation of respiratory gaseous exchange (GO:0043576)2.78137608
83cellular component assembly involved in morphogenesis (GO:0010927)2.76725195
84cytoplasmic microtubule organization (GO:0031122)2.76679487
85neurotransmitter-gated ion channel clustering (GO:0072578)2.76074052
86neurotransmitter secretion (GO:0007269)2.73747559
87parturition (GO:0007567)2.72887004
88negative regulation of immunoglobulin mediated immune response (GO:0002890)2.71398561
89negative regulation of B cell mediated immunity (GO:0002713)2.71398561
90regulation of synapse structural plasticity (GO:0051823)2.71287490
91short-term memory (GO:0007614)2.71181707
92regulation of vesicle fusion (GO:0031338)2.70511498
93cerebellar granule cell differentiation (GO:0021707)2.69760198
94reflex (GO:0060004)2.69200651
95carnitine metabolic process (GO:0009437)2.68687356
96neuronal action potential (GO:0019228)2.65857613
97sperm capacitation (GO:0048240)2.64558441
98membrane depolarization (GO:0051899)2.63753185
99adult walking behavior (GO:0007628)2.63101488
100axon ensheathment in central nervous system (GO:0032291)2.62909177
101central nervous system myelination (GO:0022010)2.62909177
102central nervous system neuron axonogenesis (GO:0021955)2.62360739
103regulation of synapse organization (GO:0050807)2.62173703
104locomotory exploration behavior (GO:0035641)2.62097277
105dendritic spine morphogenesis (GO:0060997)2.60643406
106primary alcohol metabolic process (GO:0034308)2.60487136
107neuron remodeling (GO:0016322)2.59643848
108retinoic acid metabolic process (GO:0042573)2.59253115
109nucleoside diphosphate phosphorylation (GO:0006165)2.59030006
110developmental pigmentation (GO:0048066)2.58486068
111establishment of apical/basal cell polarity (GO:0035089)2.57910431
112long-term memory (GO:0007616)2.57753452
113negative regulation of humoral immune response (GO:0002921)2.57128980
114L-amino acid import (GO:0043092)2.56596040
115synaptic vesicle exocytosis (GO:0016079)2.56529513
116regulation of neurotransmitter levels (GO:0001505)2.55359338
117pyrimidine-containing compound transmembrane transport (GO:0072531)2.54668581
118cilium morphogenesis (GO:0060271)2.54644261
119learning (GO:0007612)2.53727532
120behavioral response to ethanol (GO:0048149)2.53726658
121neurotransmitter biosynthetic process (GO:0042136)2.53044969
122regulation of dendritic spine development (GO:0060998)2.52830391
123lateral ventricle development (GO:0021670)2.52676285
124epithelial cell differentiation involved in kidney development (GO:0035850)2.52464442
125regulation of synaptic transmission, GABAergic (GO:0032228)2.52116539
126adult behavior (GO:0030534)2.51642486
127cellular sodium ion homeostasis (GO:0006883)2.51231152
128retinol metabolic process (GO:0042572)2.50100035
129terpenoid biosynthetic process (GO:0016114)2.49666379
130exogenous drug catabolic process (GO:0042738)2.49452490
131auditory receptor cell stereocilium organization (GO:0060088)2.49336039
132membrane hyperpolarization (GO:0060081)2.48791906
133positive regulation of vesicle fusion (GO:0031340)2.48400887
134regulation of dendritic spine morphogenesis (GO:0061001)2.48142641
135cranial nerve structural organization (GO:0021604)2.47831098
136glomerular epithelial cell development (GO:0072310)2.47400478
137response to dietary excess (GO:0002021)2.47033741
138synapse assembly (GO:0007416)2.45986951
139negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.45780221
140regulation of synaptic vesicle transport (GO:1902803)2.43136669
141cell projection assembly (GO:0030031)2.42390033
142establishment of planar polarity (GO:0001736)2.41784507
143establishment of tissue polarity (GO:0007164)2.41784507
144regulation of synapse maturation (GO:0090128)2.40884611
145regulation of glutamate secretion (GO:0014048)2.40723662
146regulation of microtubule depolymerization (GO:0031114)2.40418991
147cranial nerve morphogenesis (GO:0021602)2.40163590
148cell proliferation in forebrain (GO:0021846)2.39776465
149microtubule polymerization or depolymerization (GO:0031109)2.39755776
150multicellular organismal water homeostasis (GO:0050891)2.39657660
151asymmetric protein localization (GO:0008105)2.39554385
152retinal cone cell development (GO:0046549)2.38710769
153regulation of voltage-gated calcium channel activity (GO:1901385)2.38682294
154regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.38673814
155adult locomotory behavior (GO:0008344)2.38428489
156response to histamine (GO:0034776)2.38242212
157cochlea development (GO:0090102)2.38133391
158potassium ion homeostasis (GO:0055075)2.38025500
159serotonin receptor signaling pathway (GO:0007210)2.37653226
160associative learning (GO:0008306)2.37214585
161regulation of sodium ion transmembrane transport (GO:1902305)2.37082791
162behavioral response to nicotine (GO:0035095)2.36962598
163sympathetic nervous system development (GO:0048485)2.36847870
164cerebellar Purkinje cell differentiation (GO:0021702)2.36398641
165positive regulation of uterine smooth muscle contraction (GO:0070474)2.36107836
166regulation of sodium ion transmembrane transporter activity (GO:2000649)2.35903000
167positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.35871090
168negative regulation of activin receptor signaling pathway (GO:0032926)2.35714697
169female gonad development (GO:0008585)2.35414503
170quaternary ammonium group transport (GO:0015697)2.35405828
171regulation of pigment cell differentiation (GO:0050932)2.34599062
172positive regulation of membrane potential (GO:0045838)2.34508787
173mesenchymal cell differentiation involved in renal system development (GO:2001012)2.33871565
174mesenchymal cell differentiation involved in kidney development (GO:0072161)2.33871565
175dendrite development (GO:0016358)2.33816027
176neuromuscular synaptic transmission (GO:0007274)2.33495458
177neurotransmitter catabolic process (GO:0042135)2.33150217
178regulation of platelet aggregation (GO:0090330)2.32618804
179exploration behavior (GO:0035640)2.32381598
180membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32164691
181regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.31808713
182regulation of cell communication by electrical coupling (GO:0010649)2.31689671
183metanephric mesenchyme development (GO:0072075)2.31357874
184axonemal dynein complex assembly (GO:0070286)12.6396097
185cilium or flagellum-dependent cell motility (GO:0001539)11.2678043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63905146
2GBX2_23144817_ChIP-Seq_PC3_Human4.51812180
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87091265
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79866416
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.77142404
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67912359
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.63838181
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54943261
9* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.50811392
10TAF15_26573619_Chip-Seq_HEK293_Human2.50536773
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42088937
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.36266504
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.32803313
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23562311
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23547246
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22817997
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18016314
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.16601141
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14024741
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09359387
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09359387
22IGF1R_20145208_ChIP-Seq_DFB_Human2.09211325
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07316073
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97419181
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96436982
26AR_21572438_ChIP-Seq_LNCaP_Human1.96174926
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.94177122
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92125668
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.90112382
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88270379
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85356380
32RNF2_27304074_Chip-Seq_NSC_Mouse1.84681472
33P300_19829295_ChIP-Seq_ESCs_Human1.84391036
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83210411
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.81191169
36VDR_22108803_ChIP-Seq_LS180_Human1.80986835
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.79673642
38REST_21632747_ChIP-Seq_MESCs_Mouse1.79596874
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.78563559
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77002698
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76888455
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75444029
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74700390
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74613852
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69134494
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66235313
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.66213533
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.66132254
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.63950684
50* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63587587
51SMAD4_21799915_ChIP-Seq_A2780_Human1.63270312
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63132500
53AHR_22903824_ChIP-Seq_MCF-7_Human1.60982250
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60729858
55FUS_26573619_Chip-Seq_HEK293_Human1.60022977
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.58997968
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57974535
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56225886
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54264079
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.52460320
61P53_22387025_ChIP-Seq_ESCs_Mouse1.49847773
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.47653187
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46503342
64DROSHA_22980978_ChIP-Seq_HELA_Human1.46291185
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.45230296
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.44904628
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.44603518
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44422747
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.42826752
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.42581983
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.41835318
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.41316226
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40042768
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37932615
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.37625913
76P300_18555785_Chip-Seq_ESCs_Mouse1.37547510
77* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35465750
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34124431
79* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33499868
80* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33499868
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32659496
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32214111
83ER_23166858_ChIP-Seq_MCF-7_Human1.31751964
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.31029227
85STAT3_23295773_ChIP-Seq_U87_Human1.29306653
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28106497
87EWS_26573619_Chip-Seq_HEK293_Human1.27877042
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27333056
89SOX2_18555785_Chip-Seq_ESCs_Mouse1.26991469
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26022265
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23443667
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22166260
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22014260
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21857063
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.20509296
96TCF4_23295773_ChIP-Seq_U87_Human1.20037572
97TP53_18474530_ChIP-ChIP_U2OS_Human1.19276791
98AR_25329375_ChIP-Seq_VCAP_Human1.18974930
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18420373
100KLF4_18555785_Chip-Seq_ESCs_Mouse1.18175489
101PU1_27457419_Chip-Seq_LIVER_Mouse1.17911004
102RUNX2_22187159_ChIP-Seq_PCA_Human1.17235539
103RARB_27405468_Chip-Seq_BRAIN_Mouse1.15931420
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.15877612
105ZFX_18555785_Chip-Seq_ESCs_Mouse1.15553688
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15110804
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14930433
108KDM2B_26808549_Chip-Seq_REH_Human1.14483756
109SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13881602
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.13825412
111REST_18959480_ChIP-ChIP_MESCs_Mouse1.12717084
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11693697
113ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11542135
114BCAT_22108803_ChIP-Seq_LS180_Human1.11417644
115* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10829281
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.10667192
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09354536
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08278478
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06733513
120* ETV1_20927104_ChIP-Seq_GIST48_Human1.05288862
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05205039
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04964911
123SMAD4_21741376_ChIP-Seq_HESCs_Human1.03762808
124P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03751933
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02603626
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01713609
127* CTCF_27219007_Chip-Seq_Bcells_Human1.01625984
128* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00396008
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99536662
130* PHF8_20622853_ChIP-Seq_HELA_Human0.98083237
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97328329
132SOX2_20726797_ChIP-Seq_SW620_Human0.96692354
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.95906513
134* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93935580
135SMAD4_21741376_ChIP-Seq_EPCs_Human0.92854479
136AR_19668381_ChIP-Seq_PC3_Human0.92260112
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92037541
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92011780
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.90967276
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89964348
141TCF4_22108803_ChIP-Seq_LS180_Human0.89586871
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89578089
143TP63_23658742_ChIP-Seq_EP156T_Human0.87036489
144* TBL1_22424771_ChIP-Seq_293T_Human0.86726832
145CDX2_20551321_ChIP-Seq_CACO-2_Human0.85593346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.37453711
2MP0001188_hyperpigmentation3.78228110
3MP0008875_abnormal_xenobiotic_pharmacok3.77873042
4MP0004859_abnormal_synaptic_plasticity3.46487618
5MP0003136_yellow_coat_color2.73576189
6MP0002653_abnormal_ependyma_morphology2.68588528
7MP0006292_abnormal_olfactory_placode2.65254198
8MP0002735_abnormal_chemical_nociception2.61063702
9MP0005423_abnormal_somatic_nervous2.60839663
10MP0009745_abnormal_behavioral_response2.57906849
11MP0009780_abnormal_chondrocyte_physiolo2.56745347
12MP0003635_abnormal_synaptic_transmissio2.54248458
13MP0005623_abnormal_meninges_morphology2.50839839
14MP0001968_abnormal_touch/_nociception2.49436805
15MP0001486_abnormal_startle_reflex2.48772666
16MP0006276_abnormal_autonomic_nervous2.41263172
17MP0002102_abnormal_ear_morphology2.40705145
18MP0005645_abnormal_hypothalamus_physiol2.36720091
19MP0005409_darkened_coat_color2.35239763
20MP0009046_muscle_twitch2.30750160
21MP0005503_abnormal_tendon_morphology2.17216576
22MP0005646_abnormal_pituitary_gland2.14653114
23MP0004043_abnormal_pH_regulation2.14144975
24MP0002272_abnormal_nervous_system2.13576529
25MP0002572_abnormal_emotion/affect_behav2.10960747
26MP0002063_abnormal_learning/memory/cond2.09887725
27MP0002064_seizures2.08090157
28MP0002736_abnormal_nociception_after2.05240593
29MP0005171_absent_coat_pigmentation2.04071810
30MP0004742_abnormal_vestibular_system1.99627966
31MP0000778_abnormal_nervous_system1.96981028
32MP0001984_abnormal_olfaction1.94552065
33MP0004270_analgesia1.93212312
34MP0000566_synostosis1.90009090
35MP0001986_abnormal_taste_sensitivity1.89369095
36MP0002132_abnormal_respiratory_system1.88465794
37MP0004381_abnormal_hair_follicle1.82844317
38MP0000015_abnormal_ear_pigmentation1.81771490
39MP0002638_abnormal_pupillary_reflex1.80909762
40MP0002734_abnormal_mechanical_nocicepti1.79180717
41MP0002067_abnormal_sensory_capabilities1.77125059
42MP0001529_abnormal_vocalization1.72611541
43MP0002184_abnormal_innervation1.70702133
44MP0001440_abnormal_grooming_behavior1.68112778
45MP0002876_abnormal_thyroid_physiology1.67576917
46MP0001346_abnormal_lacrimal_gland1.65139527
47MP0001501_abnormal_sleep_pattern1.63091577
48MP0002557_abnormal_social/conspecific_i1.61875536
49MP0010386_abnormal_urinary_bladder1.58162334
50MP0004133_heterotaxia1.54108702
51MP0001502_abnormal_circadian_rhythm1.50094513
52MP0001905_abnormal_dopamine_level1.49464276
53MP0005275_abnormal_skin_tensile1.47875261
54MP0005551_abnormal_eye_electrophysiolog1.47686925
55MP0001970_abnormal_pain_threshold1.45895748
56MP0002277_abnormal_respiratory_mucosa1.42759086
57MP0005174_abnormal_tail_pigmentation1.39942944
58MP0003329_amyloid_beta_deposits1.38387220
59MP0002733_abnormal_thermal_nociception1.38113871
60MP0001963_abnormal_hearing_physiology1.36111951
61MP0004142_abnormal_muscle_tone1.35896087
62MP0000751_myopathy1.35574361
63MP0000026_abnormal_inner_ear1.34309826
64MP0003787_abnormal_imprinting1.33454039
65MP0008995_early_reproductive_senescence1.32108752
66MP0000569_abnormal_digit_pigmentation1.27689972
67MP0008260_abnormal_autophagy1.25654344
68MP0002160_abnormal_reproductive_system1.25559935
69MP0002909_abnormal_adrenal_gland1.23572076
70MP0009379_abnormal_foot_pigmentation1.23397179
71MP0002882_abnormal_neuron_morphology1.19711021
72MP0002752_abnormal_somatic_nervous1.18280744
73MP0000955_abnormal_spinal_cord1.17883201
74MP0003122_maternal_imprinting1.17717389
75MP0001765_abnormal_ion_homeostasis1.15576093
76MP0000631_abnormal_neuroendocrine_gland1.10942465
77MP0002282_abnormal_trachea_morphology1.10894917
78MP0005386_behavior/neurological_phenoty1.10450615
79MP0004924_abnormal_behavior1.10450615
80MP0005379_endocrine/exocrine_gland_phen1.08309010
81MP0005187_abnormal_penis_morphology1.07597927
82MP0002751_abnormal_autonomic_nervous1.04521985
83MP0004019_abnormal_vitamin_homeostasis1.04473463
84MP0005394_taste/olfaction_phenotype1.02385899
85MP0005499_abnormal_olfactory_system1.02385899
86MP0008569_lethality_at_weaning1.01336464
87MP0004885_abnormal_endolymph1.01198190
88MP0002066_abnormal_motor_capabilities/c0.99152187
89MP0005253_abnormal_eye_physiology0.98637790
90MP0001879_abnormal_lymphatic_vessel0.98526503
91MP0001485_abnormal_pinna_reflex0.97813747
92MP0005636_abnormal_mineral_homeostasis0.96839684
93MP0005451_abnormal_body_composition0.96620724
94MP0003633_abnormal_nervous_system0.95906045
95MP0002139_abnormal_hepatobiliary_system0.94638313
96MP0003938_abnormal_ear_development0.94569070
97MP0004145_abnormal_muscle_electrophysio0.94176558
98MP0002168_other_aberrant_phenotype0.94019187
99MP0004215_abnormal_myocardial_fiber0.92903467
100MP0002796_impaired_skin_barrier0.92099383
101MP0003879_abnormal_hair_cell0.90776958
102MP0006072_abnormal_retinal_apoptosis0.89044895
103MP0001664_abnormal_digestion0.88832519
104MP0002229_neurodegeneration0.87944743
105MP0003890_abnormal_embryonic-extraembry0.87779074
106MP0001299_abnormal_eye_distance/0.86250467
107MP0000579_abnormal_nail_morphology0.86121837
108MP0002163_abnormal_gland_morphology0.85634399
109MP0000383_abnormal_hair_follicle0.82068967
110MP0004264_abnormal_extraembryonic_tissu0.81097463
111MP0010678_abnormal_skin_adnexa0.79432380
112MP0008877_abnormal_DNA_methylation0.79258046
113MP0008789_abnormal_olfactory_epithelium0.77263074
114MP0004085_abnormal_heartbeat0.77150928
115MP0010030_abnormal_orbit_morphology0.76163038
116MP0000372_irregular_coat_pigmentation0.75970913
117MP0002108_abnormal_muscle_morphology0.75793615
118MP0004484_altered_response_of0.75102161
119MP0005075_abnormal_melanosome_morpholog0.75024468
120MP0003690_abnormal_glial_cell0.74375017
121MP0002095_abnormal_skin_pigmentation0.74144172
122MP0002152_abnormal_brain_morphology0.73850565
123MP0000538_abnormal_urinary_bladder0.73373863
124MP0005165_increased_susceptibility_to0.72911463
125MP0005389_reproductive_system_phenotype0.72772227
126MP0005248_abnormal_Harderian_gland0.72627137
127MP0002822_catalepsy0.72311180
128MP0003941_abnormal_skin_development0.70551525
129MP0005083_abnormal_biliary_tract0.70093912
130MP0004811_abnormal_neuron_physiology0.69229438
131MP0000049_abnormal_middle_ear0.69159304
132MP0005395_other_phenotype0.67847128
133MP0005085_abnormal_gallbladder_physiolo0.67432788
134MP0002090_abnormal_vision0.67422755
135MP0008874_decreased_physiological_sensi0.66308524
136MP0003632_abnormal_nervous_system0.66021724
137MP0000920_abnormal_myelination0.65994309
138MP0010329_abnormal_lipoprotein_level0.65594127
139MP0000681_abnormal_thyroid_gland0.61091414
140MP0002069_abnormal_eating/drinking_beha0.59615510
141MP0005195_abnormal_posterior_eye0.59449540
142MP0003631_nervous_system_phenotype0.59440655
143MP0002938_white_spotting0.59291473
144MP0000462_abnormal_digestive_system0.58416865
145MP0003137_abnormal_impulse_conducting0.58068546
146MP0003121_genomic_imprinting0.57407485

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)8.71513372
2Chronic bronchitis (HP:0004469)6.98995983
3Focal motor seizures (HP:0011153)6.02046307
4Bronchiectasis (HP:0002110)5.96798368
5Nasal polyposis (HP:0100582)4.84452259
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.79569367
7Febrile seizures (HP:0002373)4.77047324
8Abnormality of the nasal mucosa (HP:0000433)4.16352036
9Chromsome breakage (HP:0040012)4.03345567
10Infertility (HP:0000789)3.93896359
11Bronchitis (HP:0012387)3.75187005
12Hyperactive renin-angiotensin system (HP:0000841)3.63218845
13Chronic sinusitis (HP:0011109)3.47370395
14Occipital encephalocele (HP:0002085)3.39306221
15Duplicated collecting system (HP:0000081)3.33164574
16Recurrent sinusitis (HP:0011108)3.24863825
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.14299949
18Absent/shortened dynein arms (HP:0200106)3.14299949
19Recurrent otitis media (HP:0000403)3.12287399
20Broad-based gait (HP:0002136)3.08880234
21Abnormality of the renal collecting system (HP:0004742)3.06495630
22Male infertility (HP:0003251)3.04513832
23Epileptic encephalopathy (HP:0200134)2.97953766
24Focal seizures (HP:0007359)2.92956562
25Exotropia (HP:0000577)2.83279907
26Abnormal ciliary motility (HP:0012262)2.81679617
27Upper limb muscle weakness (HP:0003484)2.80069044
28Myokymia (HP:0002411)2.70313944
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.69003049
30Hyperventilation (HP:0002883)2.68105077
31Protruding tongue (HP:0010808)2.67993913
32Septo-optic dysplasia (HP:0100842)2.67817843
33Progressive cerebellar ataxia (HP:0002073)2.66405835
34Hypothermia (HP:0002045)2.63246165
35Congenital stationary night blindness (HP:0007642)2.62103880
36Absent speech (HP:0001344)2.57348042
37Fair hair (HP:0002286)2.56466707
38Atonic seizures (HP:0010819)2.48461550
39Medial flaring of the eyebrow (HP:0010747)2.46527229
40Generalized tonic-clonic seizures (HP:0002069)2.46468380
41Polyphagia (HP:0002591)2.44213394
42Abnormal hair whorl (HP:0010721)2.43368482
43Prostate neoplasm (HP:0100787)2.42449112
44True hermaphroditism (HP:0010459)2.39368055
45Generalized hypopigmentation of hair (HP:0011358)2.38504149
46Abnormal respiratory epithelium morphology (HP:0012253)2.38401955
47Abnormal respiratory motile cilium morphology (HP:0005938)2.38401955
48Gait imbalance (HP:0002141)2.33941167
49Renal salt wasting (HP:0000127)2.31753467
50Decreased central vision (HP:0007663)2.30746295
51Abnormal respiratory motile cilium physiology (HP:0012261)2.29652396
52Chronic hepatic failure (HP:0100626)2.28641823
53Parakeratosis (HP:0001036)2.25922011
54Esotropia (HP:0000565)2.20497734
55Cystic liver disease (HP:0006706)2.19225191
56Dialeptic seizures (HP:0011146)2.19050526
57Absence seizures (HP:0002121)2.18249608
58Torticollis (HP:0000473)2.18017215
59Bell-shaped thorax (HP:0001591)2.17856079
60Nephrogenic diabetes insipidus (HP:0009806)2.16045592
61Osteomalacia (HP:0002749)2.13838645
62Inability to walk (HP:0002540)2.12265517
63Pancreatic fibrosis (HP:0100732)2.11951175
64Sleep apnea (HP:0010535)2.11740648
65Abnormality of DNA repair (HP:0003254)2.09598189
66Decreased circulating renin level (HP:0003351)2.08106247
67Congenital primary aphakia (HP:0007707)2.07795270
68Optic nerve hypoplasia (HP:0000609)2.07689547
69Congenital sensorineural hearing impairment (HP:0008527)2.07599334
70Hyperkalemia (HP:0002153)2.04329639
71Duplication of thumb phalanx (HP:0009942)2.04073372
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03399350
73Abnormality of alanine metabolism (HP:0010916)2.03399350
74Hyperalaninemia (HP:0003348)2.03399350
75Abnormality of midbrain morphology (HP:0002418)2.03169222
76Molar tooth sign on MRI (HP:0002419)2.03169222
77Reduced antithrombin III activity (HP:0001976)2.02980187
78Blue irides (HP:0000635)2.02957470
79Limb dystonia (HP:0002451)2.02106899
80Abnormality of the septum pellucidum (HP:0007375)2.02079819
81Drooling (HP:0002307)2.01625393
82Excessive salivation (HP:0003781)2.01625393
83Progressive inability to walk (HP:0002505)2.00967881
84Absent septum pellucidum (HP:0001331)1.99901200
85Nephronophthisis (HP:0000090)1.98716588
86Cupped ear (HP:0000378)1.98251866
87Gaze-evoked nystagmus (HP:0000640)1.97445037
88Male pseudohermaphroditism (HP:0000037)1.96675779
89Chronic otitis media (HP:0000389)1.96489501
90Ependymoma (HP:0002888)1.95646117
91Nonprogressive disorder (HP:0003680)1.95626614
92Genital tract atresia (HP:0001827)1.94476655
93Vaginal atresia (HP:0000148)1.91622731
94Pancreatic cysts (HP:0001737)1.90977612
95Cutaneous finger syndactyly (HP:0010554)1.90899875
96White forelock (HP:0002211)1.89530882
97Microvesicular hepatic steatosis (HP:0001414)1.89368316
98Hyperaldosteronism (HP:0000859)1.88535560
99Dysdiadochokinesis (HP:0002075)1.87879642
100Abnormality of the salivary glands (HP:0010286)1.87095944
101Abnormal eating behavior (HP:0100738)1.85189748
102Hypoproteinemia (HP:0003075)1.84587483
103Fetal akinesia sequence (HP:0001989)1.83727328
104Renal agenesis (HP:0000104)1.83325748
105Action tremor (HP:0002345)1.82903054
106Aplasia/Hypoplasia of the lens (HP:0008063)1.82810789
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.82574094
108Postaxial foot polydactyly (HP:0001830)1.82110817
109Tubulointerstitial nephritis (HP:0001970)1.81929754
110Muscle fiber splitting (HP:0003555)1.81498639
111Ankle clonus (HP:0011448)1.78958987
112Anencephaly (HP:0002323)1.77947596
113Type I transferrin isoform profile (HP:0003642)1.77778610
114Thyroid-stimulating hormone excess (HP:0002925)1.76447991
115Abnormality of incisor morphology (HP:0011063)1.76034032
116Keratoconus (HP:0000563)1.75538813
117Increased corneal curvature (HP:0100692)1.75538813
118Patchy hypopigmentation of hair (HP:0011365)1.75490873
119Abnormality of the preputium (HP:0100587)1.75334775
120Abnormality of secondary sexual hair (HP:0009888)1.74073343
121Abnormality of the axillary hair (HP:0100134)1.74073343
122Atelectasis (HP:0100750)1.73567892
123Ulnar claw (HP:0001178)1.73554771
124Palpebral edema (HP:0100540)1.72744220
125Abnormality of salivation (HP:0100755)1.72313140
126Preaxial hand polydactyly (HP:0001177)1.72034000
127Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71084721
128Gastroesophageal reflux (HP:0002020)1.69544322
129Hypomagnesemia (HP:0002917)1.69501718
130Lip pit (HP:0100267)1.69167688
131Agnosia (HP:0010524)1.69001676
132Cutaneous syndactyly (HP:0012725)1.68932967
133Abnormality of the renal medulla (HP:0100957)1.68486025
134Growth hormone deficiency (HP:0000824)1.68268884
135Focal dystonia (HP:0004373)1.64929258
136Abnormality of monocarboxylic acid metabolism (HP:0010996)1.63407253
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.63288315
138Craniofacial dystonia (HP:0012179)1.63088758
139Bifid scrotum (HP:0000048)1.60868297
140Abnormality of the astrocytes (HP:0100707)1.59558572
141Astrocytoma (HP:0009592)1.59558572
142Urinary urgency (HP:0000012)1.58197129
143Abnormality of renin-angiotensin system (HP:0000847)1.52912879
144Recurrent bronchitis (HP:0002837)1.52568333
145Hypokalemic alkalosis (HP:0001949)1.50452544
146Taurodontia (HP:0000679)1.49527398
147Abnormality of permanent molar morphology (HP:0011071)1.49527398
148Abnormality of the dental root (HP:0006486)1.49527398
149Congenital hepatic fibrosis (HP:0002612)1.49019309
150Complement deficiency (HP:0004431)1.46993475
151Nephropathy (HP:0000112)1.46962171
152Akinesia (HP:0002304)1.44264758
153Abnormality of molar (HP:0011077)1.39331043
154Abnormality of molar morphology (HP:0011070)1.39331043
155Papilledema (HP:0001085)1.39157706
156Sclerocornea (HP:0000647)1.38383018
157Obstructive sleep apnea (HP:0002870)1.37674859
158Hand muscle atrophy (HP:0009130)1.33998396
159Popliteal pterygium (HP:0009756)1.33042999
160Abnormality of chloride homeostasis (HP:0011422)1.32555362
161Furrowed tongue (HP:0000221)1.31707043
162Aplasia of the musculature (HP:0100854)1.31231402
163Abnormality of the dental pulp (HP:0006479)1.31077859
164Labial hypoplasia (HP:0000066)1.30725003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.74726650
2CASK4.74418768
3MST43.55192909
4TNIK3.39369004
5PRPF4B3.14085746
6EPHA22.90665593
7NTRK32.84318263
8EPHA42.62932348
9MAP2K72.47380207
10MARK12.37943576
11TESK12.35717165
12STK162.31441407
13BRD41.99671914
14EPHA31.89563358
15MAPK131.86578530
16EIF2AK21.80044448
17MAP3K121.68866074
18MAP3K21.66009996
19MUSK1.64863737
20PDK21.63800145
21NEK61.56910213
22GRK71.55520072
23NTRK21.55301044
24ADRBK21.55095670
25INSRR1.52020519
26MAPKAPK31.49751288
27BMPR1B1.49749038
28SIK31.49744636
29CDK31.44652059
30PAK41.42474015
31ZAK1.39290885
32TSSK61.39133749
33GRK11.37205947
34TXK1.36829736
35IRAK31.31917029
36BMPR21.29935702
37MST1R1.29150988
38MAP3K41.27570319
39IRAK41.26461088
40FER1.23704437
41YES11.22915003
42WNK31.21099377
43MYLK1.18639725
44CAMKK11.16434814
45MAP4K21.15891630
46MKNK21.15301590
47LIMK11.14498815
48TTK1.14244386
49NUAK11.13807996
50PKN11.10072627
51OXSR11.08837226
52RIPK41.08799136
53PLK21.05191388
54BCR1.04373613
55AKT31.04326298
56CAMK2B1.02281093
57CAMKK20.99461389
58STK390.99348173
59CAMK2A0.98651821
60SIK20.95077344
61MET0.93410800
62FES0.92127727
63STK380.89938640
64PRKCE0.89785313
65STK240.87148403
66SGK20.86932818
67PAK30.85405162
68MINK10.85391541
69PRKCG0.85332537
70TNK20.84500693
71MAP2K40.84107490
72OBSCN0.83622179
73TAOK20.83120621
74SGK2230.82199749
75SGK4940.82199749
76RIPK10.78910425
77DYRK20.78760903
78MAP3K90.78721158
79PNCK0.78616553
80CLK10.77898438
81ARAF0.76056737
82LATS20.75649582
83CDK50.74446966
84PRKD20.74415712
85IRAK20.74044708
86MARK20.73033910
87PRKCI0.72410935
88MAP3K70.72021513
89DYRK1A0.71937085
90DAPK10.71631028
91NTRK10.67315254
92MAP3K140.66933997
93GRK50.64530648
94FGR0.62829245
95SGK10.62058201
96SRPK10.61998035
97EEF2K0.61605072
98CAMK2D0.57295385
99DAPK20.56864565
100PRKG10.56248845
101STK38L0.55867752
102UHMK10.54840487
103PTK2B0.54767022
104MAP3K30.54241309
105CAMK10.50978235
106KSR10.50188848
107MKNK10.49735688
108DYRK1B0.48913760
109WNK10.48758321
110PRKCZ0.46891015
111CDC42BPA0.46783275
112PRKACA0.45644555
113ADRBK10.45548170
114CSNK1A1L0.45318514
115PHKG20.45171193
116PHKG10.45171193
117NME10.44991465
118MAPK70.43944014
119IRAK10.43233281
120PDPK10.42776824
121STK110.42305707
122PRKCQ0.42068143
123TGFBR10.41816154
124CAMK2G0.41075821
125ERBB20.40998769
126MAPK120.40595407
127CSNK1G20.39098765
128LYN0.37998136
129MAP3K60.37953421
130PAK60.37891841
131CSNK1G30.37669912
132TIE10.37500111
133PRKAA10.36264449
134ROCK20.36071328
135TRPM70.35797383
136CSNK1D0.34109482
137ERBB30.34067625
138DAPK30.32848760
139RPS6KA30.32554219
140CSNK1E0.32428621
141CSNK1G10.31770726
142TRIM280.31660485
143PRKAA20.30996575
144CSNK1A10.30529166
145PRKCA0.30384785
146CDK190.29620079
147PRKCB0.28768106
148CDK180.27636242
149PINK10.27442977

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.52096046
2Phenylalanine metabolism_Homo sapiens_hsa003603.49165666
3Histidine metabolism_Homo sapiens_hsa003403.04955392
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.87557013
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.65951491
6Taste transduction_Homo sapiens_hsa047422.59257565
7Glutamatergic synapse_Homo sapiens_hsa047242.58602655
8Morphine addiction_Homo sapiens_hsa050322.55630935
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55329064
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.53561926
11Olfactory transduction_Homo sapiens_hsa047402.49286156
12Chemical carcinogenesis_Homo sapiens_hsa052042.39723339
13beta-Alanine metabolism_Homo sapiens_hsa004102.28270595
14Phototransduction_Homo sapiens_hsa047442.22719919
15Tyrosine metabolism_Homo sapiens_hsa003502.03088435
16GABAergic synapse_Homo sapiens_hsa047271.98902157
17* Serotonergic synapse_Homo sapiens_hsa047261.95593447
18Synaptic vesicle cycle_Homo sapiens_hsa047211.95276650
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93448563
20Amphetamine addiction_Homo sapiens_hsa050311.89319146
21Circadian entrainment_Homo sapiens_hsa047131.84753784
22Axon guidance_Homo sapiens_hsa043601.82844653
23Collecting duct acid secretion_Homo sapiens_hsa049661.71214207
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68033119
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65974923
26Calcium signaling pathway_Homo sapiens_hsa040201.64145957
27Long-term potentiation_Homo sapiens_hsa047201.58248520
28Salivary secretion_Homo sapiens_hsa049701.54735879
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48852023
30Renin secretion_Homo sapiens_hsa049241.48526995
31Dopaminergic synapse_Homo sapiens_hsa047281.44567375
32Long-term depression_Homo sapiens_hsa047301.44261184
33Retinol metabolism_Homo sapiens_hsa008301.44175525
34Insulin secretion_Homo sapiens_hsa049111.40122176
35Fanconi anemia pathway_Homo sapiens_hsa034601.38871213
36Oxidative phosphorylation_Homo sapiens_hsa001901.37580108
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35526439
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35374659
39Ether lipid metabolism_Homo sapiens_hsa005651.34111389
40Cholinergic synapse_Homo sapiens_hsa047251.30384127
41Sphingolipid metabolism_Homo sapiens_hsa006001.28642049
42Cocaine addiction_Homo sapiens_hsa050301.26628322
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23549893
44Caffeine metabolism_Homo sapiens_hsa002321.21280755
45Glutathione metabolism_Homo sapiens_hsa004801.19892572
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.17650389
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10741397
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09579638
49Arginine biosynthesis_Homo sapiens_hsa002201.09127005
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07065930
51Alzheimers disease_Homo sapiens_hsa050101.04877059
52Oxytocin signaling pathway_Homo sapiens_hsa049211.04566098
53Pyruvate metabolism_Homo sapiens_hsa006201.04490849
54Fatty acid degradation_Homo sapiens_hsa000711.04122283
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02183266
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01551219
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00933380
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00644087
59Peroxisome_Homo sapiens_hsa041460.99722060
60Rheumatoid arthritis_Homo sapiens_hsa053230.99706935
61Autoimmune thyroid disease_Homo sapiens_hsa053200.99374629
62Regulation of autophagy_Homo sapiens_hsa041400.97501028
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97249558
64Complement and coagulation cascades_Homo sapiens_hsa046100.97091821
65Tight junction_Homo sapiens_hsa045300.96940960
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.96289477
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95437399
68Arginine and proline metabolism_Homo sapiens_hsa003300.94899370
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94731754
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91056054
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89889520
72Gastric acid secretion_Homo sapiens_hsa049710.89834085
73PPAR signaling pathway_Homo sapiens_hsa033200.89808444
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87321904
75African trypanosomiasis_Homo sapiens_hsa051430.86459622
76cAMP signaling pathway_Homo sapiens_hsa040240.86182760
77Graft-versus-host disease_Homo sapiens_hsa053320.84507746
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81722643
79Arachidonic acid metabolism_Homo sapiens_hsa005900.80885490
80ErbB signaling pathway_Homo sapiens_hsa040120.78128125
81Cardiac muscle contraction_Homo sapiens_hsa042600.77841926
82Linoleic acid metabolism_Homo sapiens_hsa005910.75231941
83Ovarian steroidogenesis_Homo sapiens_hsa049130.75169687
84Bile secretion_Homo sapiens_hsa049760.75153925
85Propanoate metabolism_Homo sapiens_hsa006400.74138045
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72605379
87Gap junction_Homo sapiens_hsa045400.72105302
88Huntingtons disease_Homo sapiens_hsa050160.71509088
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.71156488
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70757304
91Asthma_Homo sapiens_hsa053100.70682997
92GnRH signaling pathway_Homo sapiens_hsa049120.70087909
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69500458
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67610735
95Fatty acid elongation_Homo sapiens_hsa000620.67188306
96Ras signaling pathway_Homo sapiens_hsa040140.66554560
97Parkinsons disease_Homo sapiens_hsa050120.65474851
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63593345
99ABC transporters_Homo sapiens_hsa020100.63470657
100Circadian rhythm_Homo sapiens_hsa047100.63327933
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62521678
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61559139
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60774975
104Pancreatic secretion_Homo sapiens_hsa049720.60354949
105Melanogenesis_Homo sapiens_hsa049160.60169796
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60003124
107Vibrio cholerae infection_Homo sapiens_hsa051100.59718713
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59256115
109MAPK signaling pathway_Homo sapiens_hsa040100.58545212
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57975686
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57388531
112Choline metabolism in cancer_Homo sapiens_hsa052310.57331602
113Type I diabetes mellitus_Homo sapiens_hsa049400.57255248
114Phagosome_Homo sapiens_hsa041450.56036287
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55746874
116Allograft rejection_Homo sapiens_hsa053300.55673159
117Wnt signaling pathway_Homo sapiens_hsa043100.55461632
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52165547
119Tryptophan metabolism_Homo sapiens_hsa003800.51993044
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50638522
121Starch and sucrose metabolism_Homo sapiens_hsa005000.49467098
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.49429284
123Steroid biosynthesis_Homo sapiens_hsa001000.48480524
124Type II diabetes mellitus_Homo sapiens_hsa049300.47949115
125Inositol phosphate metabolism_Homo sapiens_hsa005620.46908783
126Fatty acid biosynthesis_Homo sapiens_hsa000610.45439991
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43021389
128Hematopoietic cell lineage_Homo sapiens_hsa046400.42639053
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.42279348
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.41849875
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.41042341
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39456688
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39204391
134Chemokine signaling pathway_Homo sapiens_hsa040620.38716738
135Butanoate metabolism_Homo sapiens_hsa006500.37648330
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37561807
137Estrogen signaling pathway_Homo sapiens_hsa049150.35611014
138Mineral absorption_Homo sapiens_hsa049780.34975578
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.34230839
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34068266
141Dilated cardiomyopathy_Homo sapiens_hsa054140.33471647
142Alcoholism_Homo sapiens_hsa050340.30626929
143Non-homologous end-joining_Homo sapiens_hsa034500.30584973
144Vitamin digestion and absorption_Homo sapiens_hsa049770.29537249

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