CYP4Z1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1white fat cell differentiation (GO:0050872)7.10270923
2keratinocyte development (GO:0003334)6.63064082
3negative regulation of neurotransmitter secretion (GO:0046929)6.28788291
4positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)5.94664391
5smooth muscle tissue development (GO:0048745)5.60779266
6negative regulation of oligodendrocyte differentiation (GO:0048715)5.31516091
7retina homeostasis (GO:0001895)5.27247004
8lactate metabolic process (GO:0006089)5.13588981
9cartilage condensation (GO:0001502)5.11285925
10cell aggregation (GO:0098743)5.11285925
11negative regulation of JUN kinase activity (GO:0043508)5.01234458
12photoreceptor cell differentiation (GO:0046530)5.00159804
13eye photoreceptor cell differentiation (GO:0001754)5.00159804
14positive regulation of macroautophagy (GO:0016239)4.81459369
15regulation of Rac protein signal transduction (GO:0035020)4.80309599
16forebrain morphogenesis (GO:0048853)4.45714692
17glutathione biosynthetic process (GO:0006750)4.42950831
18sympathetic nervous system development (GO:0048485)4.42885475
19face development (GO:0060324)4.36331342
20Golgi to endosome transport (GO:0006895)4.29317908
21regulation of neurotransmitter uptake (GO:0051580)4.23624925
22negative regulation of transcription regulatory region DNA binding (GO:2000678)4.10976792
23NLS-bearing protein import into nucleus (GO:0006607)4.10804833
24nonribosomal peptide biosynthetic process (GO:0019184)4.10096049
25negative regulation of neurotransmitter transport (GO:0051589)3.99776694
26negative regulation of stem cell proliferation (GO:2000647)3.93425705
27myelination in peripheral nervous system (GO:0022011)3.88300863
28peripheral nervous system axon ensheathment (GO:0032292)3.88300863
29Rap protein signal transduction (GO:0032486)3.84528476
30negative regulation of circadian rhythm (GO:0042754)3.83516382
31motile cilium assembly (GO:0044458)3.82799851
32multicellular organism reproduction (GO:0032504)3.82131499
33phosphatidylinositol 3-kinase signaling (GO:0014065)3.79952874
34astrocyte development (GO:0014002)3.77350416
35negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.77293354
36ovulation from ovarian follicle (GO:0001542)3.74795394
37pharyngeal system development (GO:0060037)3.74570590
38phenylpropanoid metabolic process (GO:0009698)3.66949540
39regulation of protein polyubiquitination (GO:1902914)3.59946128
40axonemal dynein complex assembly (GO:0070286)3.58397258
41histone H3 deacetylation (GO:0070932)3.55798251
42regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.54473334
43peroxisome fission (GO:0016559)3.41990495
44regulation of respiratory burst (GO:0060263)3.34890697
45cellular response to gamma radiation (GO:0071480)3.32451188
46fusion of sperm to egg plasma membrane (GO:0007342)3.31520855
47regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.27351902
48positive regulation of protein autophosphorylation (GO:0031954)3.23257272
49positive regulation of response to extracellular stimulus (GO:0032106)3.23180898
50positive regulation of response to nutrient levels (GO:0032109)3.23180898
51positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.22938335
52regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.22938335
53lung lobe morphogenesis (GO:0060463)3.20370697
54transcytosis (GO:0045056)3.17968194
55sphingomyelin metabolic process (GO:0006684)3.15347469
56reproductive system development (GO:0061458)3.14353719
57regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.14205446
58negative regulation of osteoclast differentiation (GO:0045671)3.12312014
59phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.12302042
60proline biosynthetic process (GO:0006561)3.11956452
61detection of light stimulus involved in sensory perception (GO:0050962)3.10796811
62detection of light stimulus involved in visual perception (GO:0050908)3.10796811
63cytoskeletal anchoring at plasma membrane (GO:0007016)3.09520724
64retina layer formation (GO:0010842)3.07347242
65negative regulation of bone mineralization (GO:0030502)3.04889859
66reproduction (GO:0000003)3.00636374
67response to hydroperoxide (GO:0033194)2.98955770
68axoneme assembly (GO:0035082)2.98561883
69glutathione derivative biosynthetic process (GO:1901687)2.98186079
70glutathione derivative metabolic process (GO:1901685)2.98186079
71cilium movement (GO:0003341)2.96482064
72regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.94390589
73positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.94390589
74cilium or flagellum-dependent cell motility (GO:0001539)2.91044368
75regulation of macroautophagy (GO:0016241)2.90233326
76regulation of Rac GTPase activity (GO:0032314)2.90082563
77benzene-containing compound metabolic process (GO:0042537)2.89106905
78zinc ion transport (GO:0006829)2.88375517
79negative regulation of astrocyte differentiation (GO:0048712)2.87178487
80transepithelial transport (GO:0070633)2.85146260
81nephron tubule formation (GO:0072079)2.84434377
82indolalkylamine catabolic process (GO:0046218)2.83578980
83tryptophan catabolic process (GO:0006569)2.83578980
84indole-containing compound catabolic process (GO:0042436)2.83578980
85early endosome to late endosome transport (GO:0045022)2.82376413
86tryptophan metabolic process (GO:0006568)2.82154885
87negative regulation of cell-matrix adhesion (GO:0001953)2.81992439
88peptide biosynthetic process (GO:0043043)2.81984320
89positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.81477270
90negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.80743399
91negative regulation of biomineral tissue development (GO:0070168)2.80087929
92positive regulation of cell size (GO:0045793)2.78893288
93epithelial cilium movement (GO:0003351)2.78059830
94diol metabolic process (GO:0034311)2.76949404
95multicellular organismal water homeostasis (GO:0050891)2.76816062
96CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.73937733
97T-helper cell differentiation (GO:0042093)2.73937733
98epithelial cell differentiation involved in kidney development (GO:0035850)2.73392917
99positive regulation of cytokinesis (GO:0032467)2.72457006
100single strand break repair (GO:0000012)2.71814015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human5.49782101
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.36040705
3FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human4.14762987
4ZNF217_24962896_ChIP-Seq_MCF-7_Human3.91393548
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.64576270
6AHR_22903824_ChIP-Seq_MCF-7_Human3.40734799
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.20446892
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.16329655
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.90816710
10ARNT_22903824_ChIP-Seq_MCF-7_Human2.77783937
11FOXM1_26456572_ChIP-Seq_MCF-7_Human2.63022649
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18908615
13FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.10058836
14ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.08523104
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.06832978
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.05698161
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05070982
18FOXO3_23340844_ChIP-Seq_DLD1_Human1.98427853
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97882106
20ELF5_23300383_ChIP-Seq_T47D_Human1.85444298
21GATA3_24758297_ChIP-Seq_MCF-7_Human1.81284066
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70632817
23SOX9_24532713_ChIP-Seq_HFSC_Mouse1.66517025
24RUNX1_27514584_Chip-Seq_MCF-7_Human1.64624257
25* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.62688370
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61637713
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57782978
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.53157418
29FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.51197656
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47341023
31CJUN_26792858_Chip-Seq_BT549_Human1.47128739
32HOXB7_26014856_ChIP-Seq_BT474_Human1.45233304
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39456737
34GATA6_25053715_ChIP-Seq_YYC3_Human1.39372637
35FOXA1_25552417_ChIP-Seq_VCAP_Human1.38192041
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35001824
37* TBL1_22424771_ChIP-Seq_293T_Human1.32161349
38* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30635663
39SOX2_20726797_ChIP-Seq_SW620_Human1.21706130
40* BCAT_22108803_ChIP-Seq_LS180_Human1.21241597
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21018319
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19708591
43* TCF4_22108803_ChIP-Seq_LS180_Human1.18808465
44TCF4_18268006_ChIP-ChIP_LS174T_Human1.18321617
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17658298
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16411480
47TP63_23658742_ChIP-Seq_EP156T_Human1.15854126
48* PHF8_20622853_ChIP-Seq_HELA_Human1.15533995
49* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15529238
50ER_23166858_ChIP-Seq_MCF-7_Human1.14526082
51CBP_20019798_ChIP-Seq_JUKART_Human1.13147651
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13147651
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13074762
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.12724888
55VDR_22108803_ChIP-Seq_LS180_Human1.11925123
56* HNFA_21074721_ChIP-Seq_CACO-2_Human1.10068142
57SOX2_18555785_Chip-Seq_ESCs_Mouse1.10053026
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.08449096
59P53_22387025_ChIP-Seq_ESCs_Mouse1.08149166
60GATA4_25053715_ChIP-Seq_YYC3_Human1.07625639
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.07295546
62* GATA6_21074721_ChIP-Seq_CACO-2_Human1.06190397
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05575846
64* ETV1_20927104_ChIP-Seq_GIST48_Human1.05552583
65* RBPJ_21746931_ChIP-Seq_IB4_Human1.05551310
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04376166
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.03921164
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03196734
69AR_25329375_ChIP-Seq_VCAP_Human1.03064082
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02997059
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02669122
72* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02533818
73GBX2_23144817_ChIP-Seq_PC3_Human1.01584641
74ZFX_18555785_Chip-Seq_ESCs_Mouse1.00346244
75* CDX2_22108803_ChIP-Seq_LS180_Human1.00101530
76* NFYB_21822215_ChIP-Seq_K562_Human0.99350640
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98265360
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97883442
79OCT4_18555785_Chip-Seq_ESCs_Mouse0.97643782
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96973037
81* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96407175
82* NFYA_21822215_ChIP-Seq_K562_Human0.95884671
83RUNX2_22187159_ChIP-Seq_PCA_Human0.95460881
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95460322
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94784772
86SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93965909
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93807853
88STAT3_23295773_ChIP-Seq_U87_Human0.93698835
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92879462
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92639225
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92531077
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92531077
93LXR_22158963_ChIP-Seq_LIVER_Mouse0.92447312
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91624482
95P300_18555785_Chip-Seq_ESCs_Mouse0.91106583
96TP53_18474530_ChIP-ChIP_U2OS_Human0.90874842
97NMYC_18555785_Chip-Seq_ESCs_Mouse0.90798497
98PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89610566
99KLF5_25053715_ChIP-Seq_YYC3_Human0.89497399
100SMAD_19615063_ChIP-ChIP_OVARY_Human0.89107625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.85351929
2MP0003183_abnormal_peptide_metabolism4.63848766
3MP0002282_abnormal_trachea_morphology4.61818578
4MP0008995_early_reproductive_senescence4.14291130
5MP0005645_abnormal_hypothalamus_physiol3.92806119
6MP0003279_aneurysm3.59468772
7MP0003724_increased_susceptibility_to3.58264248
8MP0002166_altered_tumor_susceptibility3.55837939
9MP0005646_abnormal_pituitary_gland3.50130738
10MP0003045_fibrosis2.89517967
11MP0008961_abnormal_basal_metabolism2.83228810
12MP0001958_emphysema2.75594853
13MP0008057_abnormal_DNA_replication2.70564656
14MP0003195_calcinosis2.52025961
15MP0002006_tumorigenesis2.38134521
16MP0000613_abnormal_salivary_gland2.32577343
17MP0001501_abnormal_sleep_pattern2.04943255
18MP0005187_abnormal_penis_morphology2.02638071
19MP0005310_abnormal_salivary_gland2.01386279
20MP0005275_abnormal_skin_tensile2.00288491
21MP0002108_abnormal_muscle_morphology1.94414994
22MP0000767_abnormal_smooth_muscle1.88960628
23MP0001879_abnormal_lymphatic_vessel1.88165931
24MP0010234_abnormal_vibrissa_follicle1.86598897
25MP0001873_stomach_inflammation1.82585327
26MP0003786_premature_aging1.81223312
27MP0002168_other_aberrant_phenotype1.78003561
28MP0003828_pulmonary_edema1.72959058
29MP0005503_abnormal_tendon_morphology1.71252965
30MP0005670_abnormal_white_adipose1.63516288
31MP0004264_abnormal_extraembryonic_tissu1.60038436
32MP0001502_abnormal_circadian_rhythm1.49199666
33MP0010307_abnormal_tumor_latency1.38230561
34MP0002098_abnormal_vibrissa_morphology1.37016297
35MP0003191_abnormal_cellular_cholesterol1.35325627
36MP0005410_abnormal_fertilization1.32641157
37MP0010386_abnormal_urinary_bladder1.32188710
38MP0003950_abnormal_plasma_membrane1.31860439
39MP0003938_abnormal_ear_development1.25824738
40MP0009780_abnormal_chondrocyte_physiolo1.22272034
41MP0000427_abnormal_hair_cycle1.17792177
42MP0004085_abnormal_heartbeat1.16397052
43MP0005647_abnormal_sex_gland1.14955498
44MP0002796_impaired_skin_barrier1.14937690
45MP0000377_abnormal_hair_follicle1.14731366
46MP0003941_abnormal_skin_development1.13913273
47MP0001853_heart_inflammation1.12900615
48MP0002751_abnormal_autonomic_nervous1.12560209
49MP0005395_other_phenotype1.11104331
50MP0003943_abnormal_hepatobiliary_system1.10672500
51MP0002277_abnormal_respiratory_mucosa1.09666628
52MP0005083_abnormal_biliary_tract1.09134730
53MP0000647_abnormal_sebaceous_gland1.08917699
54MP0005388_respiratory_system_phenotype1.03677217
55MP0002133_abnormal_respiratory_system1.03677217
56MP0003638_abnormal_response/metabolism_1.02496443
57MP0008875_abnormal_xenobiotic_pharmacok1.02092094
58MP0004134_abnormal_chest_morphology1.00713951
59MP0002127_abnormal_cardiovascular_syste1.00044039
60MP0003690_abnormal_glial_cell0.95359214
61MP0006138_congestive_heart_failure0.89247742
62MP0002653_abnormal_ependyma_morphology0.84062015
63MP0005551_abnormal_eye_electrophysiolog0.83332838
64MP0004084_abnormal_cardiac_muscle0.82063893
65MP0004782_abnormal_surfactant_physiolog0.79801662
66MP0010678_abnormal_skin_adnexa0.79376881
67MP0000163_abnormal_cartilage_morphology0.79153282
68MP0000733_abnormal_muscle_development0.78835840
69MP0004043_abnormal_pH_regulation0.77768842
70MP0005377_hearing/vestibular/ear_phenot0.76625801
71MP0003878_abnormal_ear_physiology0.76625801
72MP0005167_abnormal_blood-brain_barrier0.75932116
73MP0001666_abnormal_nutrient_absorption0.75711350
74MP0001485_abnormal_pinna_reflex0.75005581
75MP0001765_abnormal_ion_homeostasis0.74343099
76MP0001324_abnormal_eye_pigmentation0.73508370
77MP0005636_abnormal_mineral_homeostasis0.73382916
78MP0009643_abnormal_urine_homeostasis0.72146255
79MP0000639_abnormal_adrenal_gland0.70787839
80MP0000537_abnormal_urethra_morphology0.69789886
81MP0009384_cardiac_valve_regurgitation0.67944991
82MP0002115_abnormal_skeleton_extremities0.66919476
83MP0009785_altered_susceptibility_to0.66764908
84MP0002933_joint_inflammation0.65568229
85MP0000383_abnormal_hair_follicle0.62434451
86MP0000678_abnormal_parathyroid_gland0.62354086
87MP0002254_reproductive_system_inflammat0.61967250
88MP0005166_decreased_susceptibility_to0.60342979
89MP0008438_abnormal_cutaneous_collagen0.60324967
90MP0004036_abnormal_muscle_relaxation0.59727646
91MP0002060_abnormal_skin_morphology0.59709485
92MP0001756_abnormal_urination0.59115662
93MP0000627_abnormal_mammary_gland0.57553028
94MP0004381_abnormal_hair_follicle0.56522498
95MP0003795_abnormal_bone_structure0.56446685
96MP0004147_increased_porphyrin_level0.54667669
97MP0005508_abnormal_skeleton_morphology0.54512518
98MP0000538_abnormal_urinary_bladder0.51608630
99MP0002132_abnormal_respiratory_system0.51227880
100MP0001177_atelectasis0.51021661

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous abortion (HP:0005268)7.16977862
2Pulmonary artery stenosis (HP:0004415)6.26075847
3Chronic sinusitis (HP:0011109)6.22801113
4Abnormal cartilage morphology (HP:0002763)6.02792613
5Deep philtrum (HP:0002002)5.80515707
6Concave nail (HP:0001598)5.75163161
7Recurrent bronchitis (HP:0002837)5.73659368
8Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)5.34962256
9Abnormality of the parathyroid morphology (HP:0011766)4.98421911
10Abnormality of the nasal septum (HP:0000419)4.90436541
11Astrocytoma (HP:0009592)4.65062103
12Abnormality of the astrocytes (HP:0100707)4.65062103
13Bronchitis (HP:0012387)4.61441699
14Flat capital femoral epiphysis (HP:0003370)4.60049708
15Sparse lateral eyebrow (HP:0005338)4.57158804
16Abnormality of the epiphyses of the hand (HP:0005924)4.56716017
17Abnormality of nail color (HP:0100643)4.51251519
18Short hallux (HP:0010109)4.39012582
19Pheochromocytoma (HP:0002666)4.32695083
20Abnormality involving the epiphyses of the upper limbs (HP:0003839)4.22095300
21Aplasia/Hypoplasia of the hallux (HP:0008362)4.04319274
22Nasal speech (HP:0001611)3.82438956
23Aqueductal stenosis (HP:0002410)3.77815931
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.75926742
25Abnormality of macular pigmentation (HP:0008002)3.75856073
26Infantile muscular hypotonia (HP:0008947)3.73785193
27Abnormality of the proximal phalanges of the hand (HP:0009834)3.68543997
28Abnormality of Sharpey fibers (HP:0100685)3.63187612
29Neuroendocrine neoplasm (HP:0100634)3.62765939
30Glioma (HP:0009733)3.59407778
31Chondrocalcinosis (HP:0000934)3.56921427
32Tubulointerstitial nephritis (HP:0001970)3.54116023
33Birth length less than 3rd percentile (HP:0003561)3.51631735
34Overgrowth (HP:0001548)3.50420918
35Cone-rod dystrophy (HP:0000548)3.49275667
36Hamartoma of the eye (HP:0010568)3.45741524
37Tracheal stenosis (HP:0002777)3.26141072
38Lip pit (HP:0100267)3.19325475
39Dyschromatopsia (HP:0007641)3.12355834
40Abnormality of the femoral head (HP:0003368)3.05445996
41Subcapsular cataract (HP:0000523)3.04940890
42Chronic bronchitis (HP:0004469)2.98215999
43Absent/shortened dynein arms (HP:0200106)2.94713959
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.94713959
45Hypoplasia of the capital femoral epiphysis (HP:0003090)2.88708713
46Epiphyseal stippling (HP:0010655)2.83421448
47Abnormality of the epiphysis of the femoral head (HP:0010574)2.78741676
48Rhabdomyosarcoma (HP:0002859)2.76662469
49Irregular epiphyses (HP:0010582)2.71074707
50Recurrent otitis media (HP:0000403)2.69658575
51Underdeveloped nasal alae (HP:0000430)2.62961102
52Macroorchidism (HP:0000053)2.61858705
53Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.61522894
54Posterior subcapsular cataract (HP:0007787)2.60345623
55Meningioma (HP:0002858)2.60043511
56Abnormality of femoral epiphyses (HP:0006499)2.57695986
57Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.57695986
58Abnormal respiratory motile cilium physiology (HP:0012261)2.56398039
59Follicular hyperkeratosis (HP:0007502)2.55600671
60Central scotoma (HP:0000603)2.54691052
61Abnormal delivery (HP:0001787)2.50654667
62Alopecia of scalp (HP:0002293)2.40459738
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.35104532
64Absent epiphyses (HP:0010577)2.35104532
65Relative macrocephaly (HP:0004482)2.28119789
66Abnormal ciliary motility (HP:0012262)2.28038881
67Rhinitis (HP:0012384)2.23917751
68Arterial tortuosity (HP:0005116)2.20538985
69Neoplasm of the peripheral nervous system (HP:0100007)2.08726910
70Vascular tortuosity (HP:0004948)2.06120173
71Hyperkalemia (HP:0002153)2.04580380
72Exostoses (HP:0100777)2.03189070
73Abnormal respiratory motile cilium morphology (HP:0005938)2.00271367
74Abnormal respiratory epithelium morphology (HP:0012253)2.00271367
75Decreased central vision (HP:0007663)1.99373464
76Short thumb (HP:0009778)1.97133465
77Hyperactive renin-angiotensin system (HP:0000841)1.96107409
78Cubitus valgus (HP:0002967)1.95952831
79Abnormal epiphyseal ossification (HP:0010656)1.95946417
80Hypothermia (HP:0002045)1.95108136
81Bronchiectasis (HP:0002110)1.91173388
82Midline defect of the nose (HP:0004122)1.85825583
83Neoplasm of striated muscle (HP:0009728)1.85026282
84Pili torti (HP:0003777)1.84918236
85Soft skin (HP:0000977)1.74784393
86Renal salt wasting (HP:0000127)1.73595638
87Stridor (HP:0010307)1.69695566
88Polar cataract (HP:0010696)1.69667969
89Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69090431
90Choroideremia (HP:0001139)1.68555546
91Prostate neoplasm (HP:0100787)1.67338095
92Diaphragmatic weakness (HP:0009113)1.64457214
93Absent toe (HP:0010760)1.62328796
94Severe Myopia (HP:0011003)1.61191210
95Amelogenesis imperfecta (HP:0000705)1.58602664
96Papilledema (HP:0001085)1.58128323
97Patchy hypopigmentation of hair (HP:0011365)1.57420113
98Paraparesis (HP:0002385)1.57195028
99Chorioretinal atrophy (HP:0000533)1.56869071
100Aplasia cutis congenita (HP:0001057)1.55580157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST48.05701735
2STK245.79749007
3BRSK25.34726379
4PIK3CG4.11123334
5EPHA23.37767932
6WEE13.32551058
7BRSK12.40312701
8INSRR2.20926640
9STK392.18741185
10TNK22.15123354
11MAPKAPK31.96911875
12MAPK151.90461874
13FER1.86819835
14OXSR11.77863632
15PRKCI1.69042906
16GRK11.66196222
17TRIM281.58971123
18PTK2B1.52538300
19STK101.52065268
20LRRK21.39828584
21TEC1.39468748
22BMPR21.37641081
23TGFBR21.37504683
24DYRK31.23571505
25ILK1.21373749
26PAK31.20881530
27FRK1.14716667
28STK38L1.06935888
29EEF2K1.05495216
30PKN20.97810298
31TSSK60.93616530
32LATS10.92230620
33NUAK10.91728345
34MET0.88835953
35SIK30.87319724
36PLK40.82328323
37MKNK20.81912500
38MAP3K70.79980661
39ERBB30.78957579
40AKT30.76693559
41PAK40.68978365
42ERBB20.68799839
43MAP3K20.67992438
44PTK20.67601410
45GRK50.67046343
46PRKAA20.57998919
47MST1R0.57032530
48MATK0.52273155
49RPS6KB20.52105487
50BTK0.51443166
51PRKCQ0.50832617
52OBSCN0.50150494
53ITK0.48274485
54MAPKAPK50.41432424
55TESK10.41251479
56CSNK1E0.40262949
57IKBKB0.40054088
58MUSK0.37788259
59MYLK0.37554046
60TRPM70.37464482
61SIK10.36645652
62CDK30.35536071
63ROCK10.33311032
64TAF10.32814325
65TIE10.32257601
66PRKD10.30890065
67NEK60.30827171
68VRK20.29832428
69EGFR0.28755426
70PDGFRB0.28111517
71NME10.27855430
72TBK10.27770175
73PRKAA10.27522389
74CAMK1G0.25385054
75BMX0.25378812
76NTRK30.24861456
77AKT20.24451097
78ADRBK10.24377416
79MARK20.23571383
80MTOR0.23308377
81IGF1R0.22440651
82RPS6KA20.21248964
83MAP3K130.20625498
84MAP2K10.20063990
85CDK120.20029573
86FGFR10.18639241
87MAP3K120.18572595
88CAMK1D0.17352563
89CAMK10.16939291
90TAOK30.15205512
91BCR0.14888715
92CSNK1D0.13692985
93CAMK2D0.13589655
94CHUK0.13273124
95PRKCE0.11158088
96PLK20.10635499
97JAK10.09851506
98PRKCG0.09842172
99MAPK70.09696940
100MAPK80.09517611

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047103.45851925
2Caffeine metabolism_Homo sapiens_hsa002323.39024501
3Sphingolipid metabolism_Homo sapiens_hsa006002.82491725
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.65079944
5Salivary secretion_Homo sapiens_hsa049702.48993760
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.47016915
7ABC transporters_Homo sapiens_hsa020102.42801675
8Glutathione metabolism_Homo sapiens_hsa004802.28169193
9Tyrosine metabolism_Homo sapiens_hsa003502.20187809
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11708819
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.01284285
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94900048
13Peroxisome_Homo sapiens_hsa041461.81388034
14Proteasome_Homo sapiens_hsa030501.68978812
15ECM-receptor interaction_Homo sapiens_hsa045121.67934965
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.65059984
17Fatty acid biosynthesis_Homo sapiens_hsa000611.55795708
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51373243
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49884060
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48079811
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43319434
22Chemical carcinogenesis_Homo sapiens_hsa052041.42080642
23Histidine metabolism_Homo sapiens_hsa003401.39158070
24Mineral absorption_Homo sapiens_hsa049781.36200286
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35468714
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.34922234
27Tryptophan metabolism_Homo sapiens_hsa003801.34198531
28Phenylalanine metabolism_Homo sapiens_hsa003601.31170607
29Nitrogen metabolism_Homo sapiens_hsa009101.25055598
30Olfactory transduction_Homo sapiens_hsa047401.24595212
31Fatty acid degradation_Homo sapiens_hsa000711.21190888
32Pancreatic secretion_Homo sapiens_hsa049721.18670743
33Retinol metabolism_Homo sapiens_hsa008301.16928560
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15543342
35Amphetamine addiction_Homo sapiens_hsa050311.12588507
36Fatty acid metabolism_Homo sapiens_hsa012121.11381771
37Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98819871
38Phototransduction_Homo sapiens_hsa047440.98262616
39Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98160835
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97053392
41B cell receptor signaling pathway_Homo sapiens_hsa046620.96714179
42Sulfur metabolism_Homo sapiens_hsa009200.96609111
43Tight junction_Homo sapiens_hsa045300.96588833
44Linoleic acid metabolism_Homo sapiens_hsa005910.93438804
45Arginine and proline metabolism_Homo sapiens_hsa003300.91077850
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89308176
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88258211
48Prostate cancer_Homo sapiens_hsa052150.86439518
49beta-Alanine metabolism_Homo sapiens_hsa004100.85695882
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85690853
51Dilated cardiomyopathy_Homo sapiens_hsa054140.82501873
52Renin secretion_Homo sapiens_hsa049240.82201601
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81092258
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78509411
55Taste transduction_Homo sapiens_hsa047420.75768127
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74317674
57Ovarian steroidogenesis_Homo sapiens_hsa049130.71169360
58Focal adhesion_Homo sapiens_hsa045100.69268370
59Calcium signaling pathway_Homo sapiens_hsa040200.68036605
60PPAR signaling pathway_Homo sapiens_hsa033200.66998669
61Inositol phosphate metabolism_Homo sapiens_hsa005620.66920667
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.66601023
63Complement and coagulation cascades_Homo sapiens_hsa046100.65248911
64cAMP signaling pathway_Homo sapiens_hsa040240.64975875
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64937281
66Circadian entrainment_Homo sapiens_hsa047130.64847398
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64755280
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60920191
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60636161
70Estrogen signaling pathway_Homo sapiens_hsa049150.59954747
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58756644
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58616859
73N-Glycan biosynthesis_Homo sapiens_hsa005100.58126939
74Proteoglycans in cancer_Homo sapiens_hsa052050.56658360
75T cell receptor signaling pathway_Homo sapiens_hsa046600.55712633
76Glycerolipid metabolism_Homo sapiens_hsa005610.55363353
77Fanconi anemia pathway_Homo sapiens_hsa034600.55209804
78Starch and sucrose metabolism_Homo sapiens_hsa005000.53346675
79Regulation of autophagy_Homo sapiens_hsa041400.52624768
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50964520
81Hepatitis C_Homo sapiens_hsa051600.50854654
82Protein digestion and absorption_Homo sapiens_hsa049740.48878831
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47736222
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.45919394
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45675317
86Propanoate metabolism_Homo sapiens_hsa006400.45666696
87Fatty acid elongation_Homo sapiens_hsa000620.44754119
88Gastric acid secretion_Homo sapiens_hsa049710.43709959
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41225289
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40311608
91FoxO signaling pathway_Homo sapiens_hsa040680.40256319
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39176915
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37425191
94Ether lipid metabolism_Homo sapiens_hsa005650.36189995
95Butanoate metabolism_Homo sapiens_hsa006500.34888071
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33905433
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33769659
98Arachidonic acid metabolism_Homo sapiens_hsa005900.33677371
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.31208882
100Lysine degradation_Homo sapiens_hsa003100.30387617

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