CYP51A1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glyoxylate metabolic process (GO:0046487)5.80777656
2behavioral response to nicotine (GO:0035095)5.16317394
3cellular ketone body metabolic process (GO:0046950)4.19559067
4cholesterol biosynthetic process (GO:0006695)4.07680412
5aldehyde catabolic process (GO:0046185)3.95256707
6negative regulation of execution phase of apoptosis (GO:1900118)3.92759597
7regulation of triglyceride catabolic process (GO:0010896)3.78365915
8sterol biosynthetic process (GO:0016126)3.76352021
9isoprenoid biosynthetic process (GO:0008299)3.75662835
10multicellular organism reproduction (GO:0032504)3.73295211
11ketone body metabolic process (GO:1902224)3.69057318
12DNA deamination (GO:0045006)3.62956122
13ubiquinone metabolic process (GO:0006743)3.60831774
14protein-chromophore linkage (GO:0018298)3.60058571
15water-soluble vitamin biosynthetic process (GO:0042364)3.58888904
16regulation of sequestering of triglyceride (GO:0010889)3.55930556
17serine family amino acid catabolic process (GO:0009071)3.55688012
18mannosylation (GO:0097502)3.52854387
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37501466
20response to pheromone (GO:0019236)3.33780151
21platelet dense granule organization (GO:0060155)3.32841780
222-oxoglutarate metabolic process (GO:0006103)3.30092583
23ubiquinone biosynthetic process (GO:0006744)3.27366818
24protein deneddylation (GO:0000338)3.24907921
25negative regulation of telomere maintenance (GO:0032205)3.21791564
26lymphocyte chemotaxis (GO:0048247)3.21191754
27positive regulation of meiosis (GO:0045836)3.20730228
28alanine transport (GO:0032328)3.18543470
29proteasome assembly (GO:0043248)3.17502641
30neurofilament cytoskeleton organization (GO:0060052)3.16860442
31gamma-aminobutyric acid transport (GO:0015812)3.15847657
32positive regulation of T cell cytokine production (GO:0002726)3.15174310
33metallo-sulfur cluster assembly (GO:0031163)2.97919015
34iron-sulfur cluster assembly (GO:0016226)2.97919015
35transmission of nerve impulse (GO:0019226)2.96021234
36interferon-gamma production (GO:0032609)2.95673195
37positive regulation of meiotic cell cycle (GO:0051446)2.95396270
38cofactor catabolic process (GO:0051187)2.93074458
39response to misfolded protein (GO:0051788)2.91244420
40arginine metabolic process (GO:0006525)2.87145582
41glycine metabolic process (GO:0006544)2.85889405
42auditory receptor cell stereocilium organization (GO:0060088)2.85078626
43synaptic transmission, cholinergic (GO:0007271)2.80390509
44S-adenosylmethionine metabolic process (GO:0046500)2.78220117
45oxaloacetate metabolic process (GO:0006107)2.77648528
46adenosine metabolic process (GO:0046085)2.76135449
47DNA double-strand break processing (GO:0000729)2.75707792
48serine family amino acid metabolic process (GO:0009069)2.74033243
49pyrimidine nucleobase catabolic process (GO:0006208)2.73360751
50sperm motility (GO:0030317)2.69151977
51regulation of cilium movement (GO:0003352)2.68153175
52rhodopsin mediated signaling pathway (GO:0016056)2.67111267
53coenzyme catabolic process (GO:0009109)2.66791287
54inositol phosphate-mediated signaling (GO:0048016)2.66029661
55neuron cell-cell adhesion (GO:0007158)2.61728994
56drug transmembrane transport (GO:0006855)2.61446144
57rRNA catabolic process (GO:0016075)2.61192840
58drug catabolic process (GO:0042737)2.60731644
59sperm capacitation (GO:0048240)2.60564053
60quinone biosynthetic process (GO:1901663)2.59338332
61protein polyglutamylation (GO:0018095)2.59297509
62primary amino compound metabolic process (GO:1901160)2.58128117
63sperm-egg recognition (GO:0035036)2.58079684
64C4-dicarboxylate transport (GO:0015740)2.57960473
65regulation of uterine smooth muscle contraction (GO:0070472)2.56718129
66histone H2A acetylation (GO:0043968)2.56152136
67regulation of meiosis I (GO:0060631)2.55668900
68T cell migration (GO:0072678)2.54538121
69heme transport (GO:0015886)2.53553642
70regulation of dendritic spine morphogenesis (GO:0061001)2.52578954
71kynurenine metabolic process (GO:0070189)2.52361051
72photoreceptor cell maintenance (GO:0045494)2.50402431
73positive regulation of interleukin-17 production (GO:0032740)2.49716782
74purine nucleobase biosynthetic process (GO:0009113)2.49172585
75piRNA metabolic process (GO:0034587)2.47817523
76oxidative demethylation (GO:0070989)2.47603014
77quinone metabolic process (GO:1901661)2.47305896
78positive regulation of cAMP-mediated signaling (GO:0043950)2.46416601
79basic amino acid transport (GO:0015802)2.46304113
80calcium ion import (GO:0070509)2.45588431
81protein complex biogenesis (GO:0070271)2.45327065
82mitochondrial RNA metabolic process (GO:0000959)2.45298093
83positive regulation of fatty acid oxidation (GO:0046321)2.45177357
84regulation of gene silencing by RNA (GO:0060966)2.44921357
85regulation of posttranscriptional gene silencing (GO:0060147)2.44921357
86regulation of gene silencing by miRNA (GO:0060964)2.44921357
87cilium or flagellum-dependent cell motility (GO:0001539)2.44364982
88serotonin metabolic process (GO:0042428)2.43888715
89cytokine biosynthetic process (GO:0042089)2.43568397
90presynaptic membrane assembly (GO:0097105)2.41811392
91regulation of mitochondrial translation (GO:0070129)2.40701203
92dopamine transport (GO:0015872)2.40013987
93bile acid and bile salt transport (GO:0015721)2.38773747
94mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.37308493
95dicarboxylic acid catabolic process (GO:0043649)2.37184170
96positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.36115181
97serine family amino acid biosynthetic process (GO:0009070)2.35630534
98cullin deneddylation (GO:0010388)2.35458944
99aspartate family amino acid catabolic process (GO:0009068)2.35290989
100reproduction (GO:0000003)2.35151421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.79346193
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.52343914
3VDR_22108803_ChIP-Seq_LS180_Human3.04566524
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85359330
5IGF1R_20145208_ChIP-Seq_DFB_Human2.82073821
6GBX2_23144817_ChIP-Seq_PC3_Human2.50030717
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49944799
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43211418
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39102040
10TAF15_26573619_Chip-Seq_HEK293_Human2.37658306
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.31484932
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28858510
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.14693030
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.10495949
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10434740
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10132319
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08280782
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.86152674
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79252659
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77671447
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75644549
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73763136
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71811324
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68806627
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.66253087
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65523261
27AR_20517297_ChIP-Seq_VCAP_Human1.64939574
28ER_23166858_ChIP-Seq_MCF-7_Human1.63105944
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63019976
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.60988456
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58915371
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.57136637
33FUS_26573619_Chip-Seq_HEK293_Human1.52263033
34MYC_18940864_ChIP-ChIP_HL60_Human1.51174015
35PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.50804084
36AR_21572438_ChIP-Seq_LNCaP_Human1.49422047
37TP53_22573176_ChIP-Seq_HFKS_Human1.49217912
38VDR_23849224_ChIP-Seq_CD4+_Human1.48713279
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46513516
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45726414
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.40277705
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40277705
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.39649673
44EWS_26573619_Chip-Seq_HEK293_Human1.37941373
45SOX2_19829295_ChIP-Seq_ESCs_Human1.35129789
46NANOG_19829295_ChIP-Seq_ESCs_Human1.35129789
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34229871
48CBP_20019798_ChIP-Seq_JUKART_Human1.34229871
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29067446
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.25775051
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23329549
52TAF2_19829295_ChIP-Seq_ESCs_Human1.22352321
53NCOR_22424771_ChIP-Seq_293T_Human1.21894188
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21078478
55P300_19829295_ChIP-Seq_ESCs_Human1.20253462
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.19718144
57EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19401004
58AR_25329375_ChIP-Seq_VCAP_Human1.19181776
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18156754
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17125154
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16291939
62SMAD4_21799915_ChIP-Seq_A2780_Human1.13185038
63GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.12483386
64REST_21632747_ChIP-Seq_MESCs_Mouse1.12353073
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10873766
66NFYB_21822215_ChIP-Seq_K562_Human1.10435004
67PHF8_20622853_ChIP-Seq_HELA_Human1.10314296
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08863988
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08557724
70HTT_18923047_ChIP-ChIP_STHdh_Human1.08465032
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07400228
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07291356
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05176058
74BCAT_22108803_ChIP-Seq_LS180_Human1.04752799
75RAC3_21632823_ChIP-Seq_H3396_Human1.03297433
76HNFA_21074721_ChIP-Seq_CACO-2_Human1.03214524
77ELK1_19687146_ChIP-ChIP_HELA_Human1.02907011
78RUNX2_22187159_ChIP-Seq_PCA_Human1.02747741
79MYC_19829295_ChIP-Seq_ESCs_Human1.01441756
80SALL1_21062744_ChIP-ChIP_HESCs_Human0.99852584
81CRX_20693478_ChIP-Seq_RETINA_Mouse0.99757795
82TCF4_23295773_ChIP-Seq_U87_Human0.99650891
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99557070
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99467136
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99417229
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98544829
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.98288394
88FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96930254
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96784240
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96683847
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96159291
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95430216
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.94906561
94ERG_20517297_ChIP-Seq_VCAP_Human0.94770975
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94638403
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92943088
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91702471
98TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91311157
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90600798
100ETV1_20927104_ChIP-Seq_GIST48_Human0.89604596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex4.30050955
2MP0002653_abnormal_ependyma_morphology3.91367336
3MP0009697_abnormal_copulation3.80424369
4MP0010386_abnormal_urinary_bladder3.60518368
5MP0003646_muscle_fatigue3.08417433
6MP0001529_abnormal_vocalization2.82910183
7MP0002822_catalepsy2.61756867
8MP0001764_abnormal_homeostasis2.53409965
9MP0003195_calcinosis2.51111513
10MP0002735_abnormal_chemical_nociception2.45404766
11MP0004043_abnormal_pH_regulation2.39703301
12MP0005085_abnormal_gallbladder_physiolo2.39370330
13MP0008875_abnormal_xenobiotic_pharmacok2.39224246
14MP0002139_abnormal_hepatobiliary_system2.19982373
15MP0002876_abnormal_thyroid_physiology2.13429271
16MP0005551_abnormal_eye_electrophysiolog2.12649862
17MP0003806_abnormal_nucleotide_metabolis2.10762549
18MP0001661_extended_life_span2.07346962
19MP0004742_abnormal_vestibular_system2.06466160
20MP0005253_abnormal_eye_physiology2.04411469
21MP0000372_irregular_coat_pigmentation1.84007136
22MP0005645_abnormal_hypothalamus_physiol1.83670323
23MP0003252_abnormal_bile_duct1.73251908
24MP0002138_abnormal_hepatobiliary_system1.72002077
25MP0001485_abnormal_pinna_reflex1.65124125
26MP0004142_abnormal_muscle_tone1.59119385
27MP0000538_abnormal_urinary_bladder1.58761400
28MP0005360_urolithiasis1.55103845
29MP0005365_abnormal_bile_salt1.52057370
30MP0006072_abnormal_retinal_apoptosis1.51117212
31MP0005332_abnormal_amino_acid1.49180393
32MP0001986_abnormal_taste_sensitivity1.47638502
33MP0002102_abnormal_ear_morphology1.44399226
34MP0000749_muscle_degeneration1.43307740
35MP0001905_abnormal_dopamine_level1.39998269
36MP0003868_abnormal_feces_composition1.37195303
37MP0008872_abnormal_physiological_respon1.35942920
38MP0004133_heterotaxia1.32689876
39MP0010329_abnormal_lipoprotein_level1.27277943
40MP0003718_maternal_effect1.24724168
41MP0005671_abnormal_response_to1.24527292
42MP0001502_abnormal_circadian_rhythm1.23716047
43MP0005167_abnormal_blood-brain_barrier1.18936017
44MP0003011_delayed_dark_adaptation1.18200651
45MP0001968_abnormal_touch/_nociception1.16834040
46MP0009745_abnormal_behavioral_response1.13862378
47MP0001486_abnormal_startle_reflex1.12832430
48MP0002736_abnormal_nociception_after1.12125607
49MP0002572_abnormal_emotion/affect_behav1.07093904
50MP0003045_fibrosis1.05754931
51MP0005187_abnormal_penis_morphology1.01077477
52MP0006276_abnormal_autonomic_nervous1.00233673
53MP0002272_abnormal_nervous_system0.99745315
54MP0006036_abnormal_mitochondrial_physio0.99729295
55MP0005410_abnormal_fertilization0.99426672
56MP0003638_abnormal_response/metabolism_0.98968916
57MP0002733_abnormal_thermal_nociception0.97308234
58MP0009643_abnormal_urine_homeostasis0.97088591
59MP0002064_seizures0.96131974
60MP0004019_abnormal_vitamin_homeostasis0.95716371
61MP0003890_abnormal_embryonic-extraembry0.93497862
62MP0003941_abnormal_skin_development0.92525897
63MP0004134_abnormal_chest_morphology0.92246393
64MP0000751_myopathy0.91155614
65MP0002067_abnormal_sensory_capabilities0.89898080
66MP0001970_abnormal_pain_threshold0.88989870
67MP0002909_abnormal_adrenal_gland0.88427299
68MP0005377_hearing/vestibular/ear_phenot0.87549427
69MP0003878_abnormal_ear_physiology0.87549427
70MP0002090_abnormal_vision0.86980510
71MP0004215_abnormal_myocardial_fiber0.85554037
72MP0005084_abnormal_gallbladder_morpholo0.85250009
73MP0002557_abnormal_social/conspecific_i0.84850859
74MP0003879_abnormal_hair_cell0.84267199
75MP0005386_behavior/neurological_phenoty0.83545601
76MP0004924_abnormal_behavior0.83545601
77MP0003635_abnormal_synaptic_transmissio0.83173818
78MP0002752_abnormal_somatic_nervous0.82142785
79MP0009046_muscle_twitch0.81566139
80MP0002928_abnormal_bile_duct0.80079148
81MP0006292_abnormal_olfactory_placode0.79965681
82MP0002837_dystrophic_cardiac_calcinosis0.78636486
83MP0004130_abnormal_muscle_cell0.77905060
84MP0001756_abnormal_urination0.77175589
85MP0005376_homeostasis/metabolism_phenot0.76604452
86MP0005391_vision/eye_phenotype0.74878952
87MP0004885_abnormal_endolymph0.74701887
88MP0005195_abnormal_posterior_eye0.74090698
89MP0005636_abnormal_mineral_homeostasis0.72916697
90MP0005395_other_phenotype0.72675110
91MP0000613_abnormal_salivary_gland0.71199057
92MP0000955_abnormal_spinal_cord0.70541469
93MP0001963_abnormal_hearing_physiology0.70405009
94MP0009785_altered_susceptibility_to0.69851054
95MP0001501_abnormal_sleep_pattern0.67798859
96MP0005266_abnormal_metabolism0.67410320
97MP0004145_abnormal_muscle_electrophysio0.66317389
98MP0002229_neurodegeneration0.65236331
99MP0005646_abnormal_pituitary_gland0.62711503
100MP0000427_abnormal_hair_cycle0.61894109

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)4.09222849
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.09222849
3Abnormality of alanine metabolism (HP:0010916)4.09222849
4Methylmalonic acidemia (HP:0002912)3.49501432
5Hyperglycinemia (HP:0002154)3.49072207
6Abnormality of midbrain morphology (HP:0002418)3.26477403
7Molar tooth sign on MRI (HP:0002419)3.26477403
8Decreased circulating renin level (HP:0003351)3.25350273
9Bifid tongue (HP:0010297)3.16746355
10Generalized aminoaciduria (HP:0002909)3.02044863
11Pancreatic cysts (HP:0001737)2.98081674
12Decreased activity of mitochondrial respiratory chain (HP:0008972)2.95308752
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.95308752
14Bilateral microphthalmos (HP:0007633)2.92235705
15Mesangial abnormality (HP:0001966)2.90904799
16Hyperglycinuria (HP:0003108)2.88018435
17Methylmalonic aciduria (HP:0012120)2.81833517
18Attenuation of retinal blood vessels (HP:0007843)2.77773439
19Aplastic anemia (HP:0001915)2.66981854
20True hermaphroditism (HP:0010459)2.57311063
21Increased serum pyruvate (HP:0003542)2.51811090
22Abnormality of serum amino acid levels (HP:0003112)2.47564058
23Epidermoid cyst (HP:0200040)2.47445251
24Myelomeningocele (HP:0002475)2.45727765
25Increased serum lactate (HP:0002151)2.45602995
26Chronic bronchitis (HP:0004469)2.44808828
27Acute encephalopathy (HP:0006846)2.43419668
28Hypokalemia (HP:0002900)2.40786862
29Ulnar claw (HP:0001178)2.40331229
30Abolished electroretinogram (ERG) (HP:0000550)2.39637474
31Hepatocellular necrosis (HP:0001404)2.39113864
32Pancreatic fibrosis (HP:0100732)2.39008454
33Abnormal mitochondria in muscle tissue (HP:0008316)2.37665265
34Hepatic necrosis (HP:0002605)2.37199164
35Exocrine pancreatic insufficiency (HP:0001738)2.36406164
36Hypoproteinemia (HP:0003075)2.36293611
37Abnormality of serine family amino acid metabolism (HP:0010894)2.34240388
38Abnormality of glycine metabolism (HP:0010895)2.34240388
39Lactic acidosis (HP:0003128)2.31360387
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31324085
41Pendular nystagmus (HP:0012043)2.30971566
42Metabolic acidosis (HP:0001942)2.30153481
43Type II lissencephaly (HP:0007260)2.28866091
44Increased CSF lactate (HP:0002490)2.26665077
45Hypokalemic alkalosis (HP:0001949)2.25206392
46Abnormal biliary tract physiology (HP:0012439)2.23401246
47Bile duct proliferation (HP:0001408)2.23401246
48Gait imbalance (HP:0002141)2.21947719
49Type I transferrin isoform profile (HP:0003642)2.21264794
50Abnormality of glycolysis (HP:0004366)2.20596702
51Reduced antithrombin III activity (HP:0001976)2.20572226
52Mitochondrial inheritance (HP:0001427)2.19897526
53Acute necrotizing encephalopathy (HP:0006965)2.19703057
54Nephrogenic diabetes insipidus (HP:0009806)2.19351531
55Lissencephaly (HP:0001339)2.18004946
56Ketoacidosis (HP:0001993)2.16830908
57Hyperlipoproteinemia (HP:0010980)2.15556386
58Brushfield spots (HP:0001088)2.14224409
59Multiple enchondromatosis (HP:0005701)2.13314152
60Congenital primary aphakia (HP:0007707)2.10966655
61Neonatal respiratory distress (HP:0002643)2.10733945
62Recurrent corneal erosions (HP:0000495)2.09930021
63Horizontal nystagmus (HP:0000666)2.09287628
64Congenital stationary night blindness (HP:0007642)2.09060425
65Chorioretinal atrophy (HP:0000533)2.08858142
66Dicarboxylic aciduria (HP:0003215)2.05961694
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05961694
68Vaginal atresia (HP:0000148)2.05359978
69Global brain atrophy (HP:0002283)2.05330066
70Hyperammonemia (HP:0001987)2.04751583
71Confusion (HP:0001289)2.04731345
72Medial flaring of the eyebrow (HP:0010747)2.03261890
73Anencephaly (HP:0002323)2.02424964
74Bilateral sensorineural hearing impairment (HP:0008619)2.01380978
75Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00326202
76Genital tract atresia (HP:0001827)1.99871481
77Alkalosis (HP:0001948)1.97883799
78Hyperactive renin-angiotensin system (HP:0000841)1.95463906
79Large for gestational age (HP:0001520)1.95396508
80Abnormal drinking behavior (HP:0030082)1.94645327
81Polydipsia (HP:0001959)1.94645327
82Abnormality of vitamin metabolism (HP:0100508)1.94148288
83Epiphyseal stippling (HP:0010655)1.92061331
84Abnormal rod and cone electroretinograms (HP:0008323)1.91599845
85Optic disc pallor (HP:0000543)1.90903975
86Bicornuate uterus (HP:0000813)1.90681909
87Increased intramyocellular lipid droplets (HP:0012240)1.89794026
88Hyperkalemia (HP:0002153)1.89692909
89Lethargy (HP:0001254)1.89438112
90Renal Fanconi syndrome (HP:0001994)1.89273995
91Progressive macrocephaly (HP:0004481)1.87303318
92Unilateral renal agenesis (HP:0000122)1.87029401
93Abnormality of macular pigmentation (HP:0008002)1.86938257
94Abnormality of the vitamin B12 metabolism (HP:0004341)1.85066771
95Abnormality of renin-angiotensin system (HP:0000847)1.84541147
96Ketosis (HP:0001946)1.81445285
97Decreased central vision (HP:0007663)1.80483279
98Abnormality of the pubic bones (HP:0003172)1.80241334
99Abnormality of potassium homeostasis (HP:0011042)1.76345838
100IgM deficiency (HP:0002850)1.75707579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.22852609
2FRK4.03187058
3INSRR3.68032539
4SIK22.98471720
5VRK22.83642254
6PDK22.55838062
7MAP3K122.46118187
8NEK92.42110865
9PNCK2.21382054
10CCNB12.12003062
11MAPKAPK32.05784106
12ADRBK22.00690061
13ZAK1.87354579
14PIK3CG1.84636336
15MAP4K21.82734310
16PRKD31.82243855
17GRK11.53359595
18TEC1.52542487
19TLK11.48811983
20WNK41.42226251
21PIM21.41396585
22NEK11.39788303
23NUAK11.38875947
24TAOK31.35268379
25PINK11.34054520
26MAPKAPK51.31615519
27OBSCN1.28273547
28MAP4K11.26795756
29KDR1.25767699
30MST41.21850155
31STK38L1.17991868
32CSNK1G31.17459342
33EPHA41.17033972
34TSSK61.16579208
35MAPK131.15795352
36MAP3K111.13445043
37MARK11.07697198
38OXSR11.07260376
39PHKG11.06585230
40PHKG21.06585230
41TNK21.05256985
42VRK11.00607791
43ITK1.00376186
44SIK30.96316007
45RPS6KA50.91181491
46CDC70.87149838
47BCKDK0.86300825
48MUSK0.86133460
49DYRK20.85525238
50CSNK1G20.82743174
51CSNK1A1L0.80792625
52TAF10.75868003
53CSNK1G10.75413693
54MAP2K70.72384714
55PRKCQ0.71960363
56MINK10.70177867
57DAPK30.69409082
58PRKCG0.67535133
59LIMK10.65767790
60ERBB30.64748581
61ADRBK10.62873297
62NEK20.56140456
63NME10.55806832
64STK380.52948449
65GRK50.50606152
66AKT20.50246781
67MAP3K50.49792352
68PRKAA10.49777457
69PTK2B0.49257106
70PRKAA20.49228726
71EPHA30.48477721
72DAPK10.48469375
73CAMK2A0.48344148
74IGF1R0.47093539
75PRKG20.45711803
76MYLK0.45042202
77FLT30.44183669
78LCK0.44168261
79CDK90.43631375
80MAPK150.41432738
81NEK60.41248331
82CAMK1G0.40647213
83PRKCE0.40639038
84PRKACA0.39872849
85MKNK10.39686109
86CSNK1A10.38656908
87NTRK10.37635002
88SYK0.37263202
89PASK0.36687721
90CAMK40.35591505
91TBK10.35556050
92AURKA0.32970818
93PRKCA0.32787798
94PRKG10.32691895
95PBK0.32060343
96GRK60.31073578
97ABL10.30533255
98EPHB10.29004175
99TRPM70.27724916
100PLK10.27706742

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.08766864
2Selenocompound metabolism_Homo sapiens_hsa004503.00480812
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95512496
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.59646231
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.50049784
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.42242770
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.39549558
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15172003
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03813379
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03410615
11Butanoate metabolism_Homo sapiens_hsa006502.03320390
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95057304
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.92204145
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91245229
15Proteasome_Homo sapiens_hsa030501.89339239
16Peroxisome_Homo sapiens_hsa041461.88929167
17Oxidative phosphorylation_Homo sapiens_hsa001901.83461153
18Linoleic acid metabolism_Homo sapiens_hsa005911.80255980
19Primary immunodeficiency_Homo sapiens_hsa053401.79453125
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.64923389
21Sulfur metabolism_Homo sapiens_hsa009201.63289764
22Propanoate metabolism_Homo sapiens_hsa006401.54584510
23Pyruvate metabolism_Homo sapiens_hsa006201.53039004
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52132533
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49643803
26Sulfur relay system_Homo sapiens_hsa041221.49379309
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.48758606
28Retinol metabolism_Homo sapiens_hsa008301.48078761
29Protein export_Homo sapiens_hsa030601.46562159
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43907690
31Parkinsons disease_Homo sapiens_hsa050121.41162010
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30800566
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27790343
34Fatty acid metabolism_Homo sapiens_hsa012121.24935474
35Chemical carcinogenesis_Homo sapiens_hsa052041.21216485
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.19208496
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18608640
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17968640
39Arginine biosynthesis_Homo sapiens_hsa002201.16218492
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15617801
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15591220
42Tryptophan metabolism_Homo sapiens_hsa003801.14175794
43One carbon pool by folate_Homo sapiens_hsa006701.12176646
44Biosynthesis of amino acids_Homo sapiens_hsa012301.11891036
45Arachidonic acid metabolism_Homo sapiens_hsa005901.09144330
46Carbon metabolism_Homo sapiens_hsa012001.08504441
47Fatty acid elongation_Homo sapiens_hsa000621.05317610
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05242548
49Phototransduction_Homo sapiens_hsa047441.04394693
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.02134268
51Nicotine addiction_Homo sapiens_hsa050331.00502865
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97295678
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95168281
54Huntingtons disease_Homo sapiens_hsa050160.94597603
55Olfactory transduction_Homo sapiens_hsa047400.94176277
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93671346
57Fat digestion and absorption_Homo sapiens_hsa049750.93310516
58RNA polymerase_Homo sapiens_hsa030200.93192496
59Collecting duct acid secretion_Homo sapiens_hsa049660.92101218
60Taste transduction_Homo sapiens_hsa047420.90722018
61Basal transcription factors_Homo sapiens_hsa030220.88314997
62Ether lipid metabolism_Homo sapiens_hsa005650.87174564
63Systemic lupus erythematosus_Homo sapiens_hsa053220.85714725
64Nitrogen metabolism_Homo sapiens_hsa009100.84779159
65Bile secretion_Homo sapiens_hsa049760.83453368
66Alzheimers disease_Homo sapiens_hsa050100.83013483
67Glycerolipid metabolism_Homo sapiens_hsa005610.79589727
68Fatty acid degradation_Homo sapiens_hsa000710.78256541
69Cardiac muscle contraction_Homo sapiens_hsa042600.77041243
70Metabolic pathways_Homo sapiens_hsa011000.75886618
71Arginine and proline metabolism_Homo sapiens_hsa003300.67419396
72Non-homologous end-joining_Homo sapiens_hsa034500.67405155
73beta-Alanine metabolism_Homo sapiens_hsa004100.64069839
74GABAergic synapse_Homo sapiens_hsa047270.63407187
75Ovarian steroidogenesis_Homo sapiens_hsa049130.63354109
76Pentose phosphate pathway_Homo sapiens_hsa000300.62367480
77Alcoholism_Homo sapiens_hsa050340.60895139
78Phenylalanine metabolism_Homo sapiens_hsa003600.57562109
79Caffeine metabolism_Homo sapiens_hsa002320.55422408
80Homologous recombination_Homo sapiens_hsa034400.54913247
81Synaptic vesicle cycle_Homo sapiens_hsa047210.51028449
82Folate biosynthesis_Homo sapiens_hsa007900.50412263
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49944205
84Starch and sucrose metabolism_Homo sapiens_hsa005000.48605455
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.47920434
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47401352
87Morphine addiction_Homo sapiens_hsa050320.46424695
88Vitamin digestion and absorption_Homo sapiens_hsa049770.45335398
89Complement and coagulation cascades_Homo sapiens_hsa046100.43098774
90PPAR signaling pathway_Homo sapiens_hsa033200.41152528
91ABC transporters_Homo sapiens_hsa020100.40938120
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39196361
93Glutamatergic synapse_Homo sapiens_hsa047240.37778623
94Antigen processing and presentation_Homo sapiens_hsa046120.37640447
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34008311
96Glutathione metabolism_Homo sapiens_hsa004800.33179452
97Serotonergic synapse_Homo sapiens_hsa047260.31883572
98Sphingolipid metabolism_Homo sapiens_hsa006000.30345865
99Purine metabolism_Homo sapiens_hsa002300.29409376
100Fanconi anemia pathway_Homo sapiens_hsa034600.29110056

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