ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glyoxylate metabolic process (GO:0046487)	5.80777656
2	behavioral response to nicotine (GO:0035095)	5.16317394
3	cellular ketone body metabolic process (GO:0046950)	4.19559067
4	cholesterol biosynthetic process (GO:0006695)	4.07680412
5	aldehyde catabolic process (GO:0046185)	3.95256707
6	negative regulation of execution phase of apoptosis (GO:1900118)	3.92759597
7	regulation of triglyceride catabolic process (GO:0010896)	3.78365915
8	sterol biosynthetic process (GO:0016126)	3.76352021
9	isoprenoid biosynthetic process (GO:0008299)	3.75662835
10	multicellular organism reproduction (GO:0032504)	3.73295211
11	ketone body metabolic process (GO:1902224)	3.69057318
12	DNA deamination (GO:0045006)	3.62956122
13	ubiquinone metabolic process (GO:0006743)	3.60831774
14	protein-chromophore linkage (GO:0018298)	3.60058571
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.58888904
16	regulation of sequestering of triglyceride (GO:0010889)	3.55930556
17	serine family amino acid catabolic process (GO:0009071)	3.55688012
18	mannosylation (GO:0097502)	3.52854387
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.37501466
20	response to pheromone (GO:0019236)	3.33780151
21	platelet dense granule organization (GO:0060155)	3.32841780
22	2-oxoglutarate metabolic process (GO:0006103)	3.30092583
23	ubiquinone biosynthetic process (GO:0006744)	3.27366818
24	protein deneddylation (GO:0000338)	3.24907921
25	negative regulation of telomere maintenance (GO:0032205)	3.21791564
26	lymphocyte chemotaxis (GO:0048247)	3.21191754
27	positive regulation of meiosis (GO:0045836)	3.20730228
28	alanine transport (GO:0032328)	3.18543470
29	proteasome assembly (GO:0043248)	3.17502641
30	neurofilament cytoskeleton organization (GO:0060052)	3.16860442
31	gamma-aminobutyric acid transport (GO:0015812)	3.15847657
32	positive regulation of T cell cytokine production (GO:0002726)	3.15174310
33	metallo-sulfur cluster assembly (GO:0031163)	2.97919015
34	iron-sulfur cluster assembly (GO:0016226)	2.97919015
35	transmission of nerve impulse (GO:0019226)	2.96021234
36	interferon-gamma production (GO:0032609)	2.95673195
37	positive regulation of meiotic cell cycle (GO:0051446)	2.95396270
38	cofactor catabolic process (GO:0051187)	2.93074458
39	response to misfolded protein (GO:0051788)	2.91244420
40	arginine metabolic process (GO:0006525)	2.87145582
41	glycine metabolic process (GO:0006544)	2.85889405
42	auditory receptor cell stereocilium organization (GO:0060088)	2.85078626
43	synaptic transmission, cholinergic (GO:0007271)	2.80390509
44	S-adenosylmethionine metabolic process (GO:0046500)	2.78220117
45	oxaloacetate metabolic process (GO:0006107)	2.77648528
46	adenosine metabolic process (GO:0046085)	2.76135449
47	DNA double-strand break processing (GO:0000729)	2.75707792
48	serine family amino acid metabolic process (GO:0009069)	2.74033243
49	pyrimidine nucleobase catabolic process (GO:0006208)	2.73360751
50	sperm motility (GO:0030317)	2.69151977
51	regulation of cilium movement (GO:0003352)	2.68153175
52	rhodopsin mediated signaling pathway (GO:0016056)	2.67111267
53	coenzyme catabolic process (GO:0009109)	2.66791287
54	inositol phosphate-mediated signaling (GO:0048016)	2.66029661
55	neuron cell-cell adhesion (GO:0007158)	2.61728994
56	drug transmembrane transport (GO:0006855)	2.61446144
57	rRNA catabolic process (GO:0016075)	2.61192840
58	drug catabolic process (GO:0042737)	2.60731644
59	sperm capacitation (GO:0048240)	2.60564053
60	quinone biosynthetic process (GO:1901663)	2.59338332
61	protein polyglutamylation (GO:0018095)	2.59297509
62	primary amino compound metabolic process (GO:1901160)	2.58128117
63	sperm-egg recognition (GO:0035036)	2.58079684
64	C4-dicarboxylate transport (GO:0015740)	2.57960473
65	regulation of uterine smooth muscle contraction (GO:0070472)	2.56718129
66	histone H2A acetylation (GO:0043968)	2.56152136
67	regulation of meiosis I (GO:0060631)	2.55668900
68	T cell migration (GO:0072678)	2.54538121
69	heme transport (GO:0015886)	2.53553642
70	regulation of dendritic spine morphogenesis (GO:0061001)	2.52578954
71	kynurenine metabolic process (GO:0070189)	2.52361051
72	photoreceptor cell maintenance (GO:0045494)	2.50402431
73	positive regulation of interleukin-17 production (GO:0032740)	2.49716782
74	purine nucleobase biosynthetic process (GO:0009113)	2.49172585
75	piRNA metabolic process (GO:0034587)	2.47817523
76	oxidative demethylation (GO:0070989)	2.47603014
77	quinone metabolic process (GO:1901661)	2.47305896
78	positive regulation of cAMP-mediated signaling (GO:0043950)	2.46416601
79	basic amino acid transport (GO:0015802)	2.46304113
80	calcium ion import (GO:0070509)	2.45588431
81	protein complex biogenesis (GO:0070271)	2.45327065
82	mitochondrial RNA metabolic process (GO:0000959)	2.45298093
83	positive regulation of fatty acid oxidation (GO:0046321)	2.45177357
84	regulation of gene silencing by RNA (GO:0060966)	2.44921357
85	regulation of posttranscriptional gene silencing (GO:0060147)	2.44921357
86	regulation of gene silencing by miRNA (GO:0060964)	2.44921357
87	cilium or flagellum-dependent cell motility (GO:0001539)	2.44364982
88	serotonin metabolic process (GO:0042428)	2.43888715
89	cytokine biosynthetic process (GO:0042089)	2.43568397
90	presynaptic membrane assembly (GO:0097105)	2.41811392
91	regulation of mitochondrial translation (GO:0070129)	2.40701203
92	dopamine transport (GO:0015872)	2.40013987
93	bile acid and bile salt transport (GO:0015721)	2.38773747
94	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.37308493
95	dicarboxylic acid catabolic process (GO:0043649)	2.37184170
96	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	2.36115181
97	serine family amino acid biosynthetic process (GO:0009070)	2.35630534
98	cullin deneddylation (GO:0010388)	2.35458944
99	aspartate family amino acid catabolic process (GO:0009068)	2.35290989
100	reproduction (GO:0000003)	2.35151421

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.79346193
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.52343914
3	VDR_22108803_ChIP-Seq_LS180_Human	3.04566524
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.85359330
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.82073821
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.50030717
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.49944799
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.43211418
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.39102040
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.37658306
11	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.31484932
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.28858510
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14693030
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.10495949
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.10434740
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.10132319
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.08280782
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.86152674
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79252659
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77671447
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.75644549
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73763136
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.71811324
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68806627
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.66253087
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.65523261
27	AR_20517297_ChIP-Seq_VCAP_Human	1.64939574
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.63105944
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.63019976
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.60988456
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58915371
32	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.57136637
33	FUS_26573619_Chip-Seq_HEK293_Human	1.52263033
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.51174015
35	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.50804084
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.49422047
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.49217912
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.48713279
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46513516
40	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.45726414
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40277705
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40277705
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.39649673
44	EWS_26573619_Chip-Seq_HEK293_Human	1.37941373
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35129789
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35129789
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34229871
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.34229871
49	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.29067446
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25775051
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23329549
52	TAF2_19829295_ChIP-Seq_ESCs_Human	1.22352321
53	NCOR_22424771_ChIP-Seq_293T_Human	1.21894188
54	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.21078478
55	P300_19829295_ChIP-Seq_ESCs_Human	1.20253462
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19718144
57	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.19401004
58	AR_25329375_ChIP-Seq_VCAP_Human	1.19181776
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18156754
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17125154
61	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.16291939
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.13185038
63	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.12483386
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12353073
65	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10873766
66	NFYB_21822215_ChIP-Seq_K562_Human	1.10435004
67	PHF8_20622853_ChIP-Seq_HELA_Human	1.10314296
68	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.08863988
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08557724
70	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08465032
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07400228
72	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.07291356
73	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.05176058
74	BCAT_22108803_ChIP-Seq_LS180_Human	1.04752799
75	RAC3_21632823_ChIP-Seq_H3396_Human	1.03297433
76	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.03214524
77	ELK1_19687146_ChIP-ChIP_HELA_Human	1.02907011
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02747741
79	MYC_19829295_ChIP-Seq_ESCs_Human	1.01441756
80	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.99852584
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99757795
82	TCF4_23295773_ChIP-Seq_U87_Human	0.99650891
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99557070
84	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99467136
85	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99417229
86	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98544829
87	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.98288394
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96930254
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96784240
90	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96683847
91	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.96159291
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95430216
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94906561
94	ERG_20517297_ChIP-Seq_VCAP_Human	0.94770975
95	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94638403
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92943088
97	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.91702471
98	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.91311157
99	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.90600798
100	ETV1_20927104_ChIP-Seq_GIST48_Human	0.89604596

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	4.30050955
2	MP0002653_abnormal_ependyma_morphology	3.91367336
3	MP0009697_abnormal_copulation	3.80424369
4	MP0010386_abnormal_urinary_bladder	3.60518368
5	MP0003646_muscle_fatigue	3.08417433
6	MP0001529_abnormal_vocalization	2.82910183
7	MP0002822_catalepsy	2.61756867
8	MP0001764_abnormal_homeostasis	2.53409965
9	MP0003195_calcinosis	2.51111513
10	MP0002735_abnormal_chemical_nociception	2.45404766
11	MP0004043_abnormal_pH_regulation	2.39703301
12	MP0005085_abnormal_gallbladder_physiolo	2.39370330
13	MP0008875_abnormal_xenobiotic_pharmacok	2.39224246
14	MP0002139_abnormal_hepatobiliary_system	2.19982373
15	MP0002876_abnormal_thyroid_physiology	2.13429271
16	MP0005551_abnormal_eye_electrophysiolog	2.12649862
17	MP0003806_abnormal_nucleotide_metabolis	2.10762549
18	MP0001661_extended_life_span	2.07346962
19	MP0004742_abnormal_vestibular_system	2.06466160
20	MP0005253_abnormal_eye_physiology	2.04411469
21	MP0000372_irregular_coat_pigmentation	1.84007136
22	MP0005645_abnormal_hypothalamus_physiol	1.83670323
23	MP0003252_abnormal_bile_duct	1.73251908
24	MP0002138_abnormal_hepatobiliary_system	1.72002077
25	MP0001485_abnormal_pinna_reflex	1.65124125
26	MP0004142_abnormal_muscle_tone	1.59119385
27	MP0000538_abnormal_urinary_bladder	1.58761400
28	MP0005360_urolithiasis	1.55103845
29	MP0005365_abnormal_bile_salt	1.52057370
30	MP0006072_abnormal_retinal_apoptosis	1.51117212
31	MP0005332_abnormal_amino_acid	1.49180393
32	MP0001986_abnormal_taste_sensitivity	1.47638502
33	MP0002102_abnormal_ear_morphology	1.44399226
34	MP0000749_muscle_degeneration	1.43307740
35	MP0001905_abnormal_dopamine_level	1.39998269
36	MP0003868_abnormal_feces_composition	1.37195303
37	MP0008872_abnormal_physiological_respon	1.35942920
38	MP0004133_heterotaxia	1.32689876
39	MP0010329_abnormal_lipoprotein_level	1.27277943
40	MP0003718_maternal_effect	1.24724168
41	MP0005671_abnormal_response_to	1.24527292
42	MP0001502_abnormal_circadian_rhythm	1.23716047
43	MP0005167_abnormal_blood-brain_barrier	1.18936017
44	MP0003011_delayed_dark_adaptation	1.18200651
45	MP0001968_abnormal_touch/_nociception	1.16834040
46	MP0009745_abnormal_behavioral_response	1.13862378
47	MP0001486_abnormal_startle_reflex	1.12832430
48	MP0002736_abnormal_nociception_after	1.12125607
49	MP0002572_abnormal_emotion/affect_behav	1.07093904
50	MP0003045_fibrosis	1.05754931
51	MP0005187_abnormal_penis_morphology	1.01077477
52	MP0006276_abnormal_autonomic_nervous	1.00233673
53	MP0002272_abnormal_nervous_system	0.99745315
54	MP0006036_abnormal_mitochondrial_physio	0.99729295
55	MP0005410_abnormal_fertilization	0.99426672
56	MP0003638_abnormal_response/metabolism_	0.98968916
57	MP0002733_abnormal_thermal_nociception	0.97308234
58	MP0009643_abnormal_urine_homeostasis	0.97088591
59	MP0002064_seizures	0.96131974
60	MP0004019_abnormal_vitamin_homeostasis	0.95716371
61	MP0003890_abnormal_embryonic-extraembry	0.93497862
62	MP0003941_abnormal_skin_development	0.92525897
63	MP0004134_abnormal_chest_morphology	0.92246393
64	MP0000751_myopathy	0.91155614
65	MP0002067_abnormal_sensory_capabilities	0.89898080
66	MP0001970_abnormal_pain_threshold	0.88989870
67	MP0002909_abnormal_adrenal_gland	0.88427299
68	MP0005377_hearing/vestibular/ear_phenot	0.87549427
69	MP0003878_abnormal_ear_physiology	0.87549427
70	MP0002090_abnormal_vision	0.86980510
71	MP0004215_abnormal_myocardial_fiber	0.85554037
72	MP0005084_abnormal_gallbladder_morpholo	0.85250009
73	MP0002557_abnormal_social/conspecific_i	0.84850859
74	MP0003879_abnormal_hair_cell	0.84267199
75	MP0005386_behavior/neurological_phenoty	0.83545601
76	MP0004924_abnormal_behavior	0.83545601
77	MP0003635_abnormal_synaptic_transmissio	0.83173818
78	MP0002752_abnormal_somatic_nervous	0.82142785
79	MP0009046_muscle_twitch	0.81566139
80	MP0002928_abnormal_bile_duct	0.80079148
81	MP0006292_abnormal_olfactory_placode	0.79965681
82	MP0002837_dystrophic_cardiac_calcinosis	0.78636486
83	MP0004130_abnormal_muscle_cell	0.77905060
84	MP0001756_abnormal_urination	0.77175589
85	MP0005376_homeostasis/metabolism_phenot	0.76604452
86	MP0005391_vision/eye_phenotype	0.74878952
87	MP0004885_abnormal_endolymph	0.74701887
88	MP0005195_abnormal_posterior_eye	0.74090698
89	MP0005636_abnormal_mineral_homeostasis	0.72916697
90	MP0005395_other_phenotype	0.72675110
91	MP0000613_abnormal_salivary_gland	0.71199057
92	MP0000955_abnormal_spinal_cord	0.70541469
93	MP0001963_abnormal_hearing_physiology	0.70405009
94	MP0009785_altered_susceptibility_to	0.69851054
95	MP0001501_abnormal_sleep_pattern	0.67798859
96	MP0005266_abnormal_metabolism	0.67410320
97	MP0004145_abnormal_muscle_electrophysio	0.66317389
98	MP0002229_neurodegeneration	0.65236331
99	MP0005646_abnormal_pituitary_gland	0.62711503
100	MP0000427_abnormal_hair_cycle	0.61894109

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperalaninemia (HP:0003348)	4.09222849
2	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.09222849
3	Abnormality of alanine metabolism (HP:0010916)	4.09222849
4	Methylmalonic acidemia (HP:0002912)	3.49501432
5	Hyperglycinemia (HP:0002154)	3.49072207
6	Abnormality of midbrain morphology (HP:0002418)	3.26477403
7	Molar tooth sign on MRI (HP:0002419)	3.26477403
8	Decreased circulating renin level (HP:0003351)	3.25350273
9	Bifid tongue (HP:0010297)	3.16746355
10	Generalized aminoaciduria (HP:0002909)	3.02044863
11	Pancreatic cysts (HP:0001737)	2.98081674
12	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.95308752
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.95308752
14	Bilateral microphthalmos (HP:0007633)	2.92235705
15	Mesangial abnormality (HP:0001966)	2.90904799
16	Hyperglycinuria (HP:0003108)	2.88018435
17	Methylmalonic aciduria (HP:0012120)	2.81833517
18	Attenuation of retinal blood vessels (HP:0007843)	2.77773439
19	Aplastic anemia (HP:0001915)	2.66981854
20	True hermaphroditism (HP:0010459)	2.57311063
21	Increased serum pyruvate (HP:0003542)	2.51811090
22	Abnormality of serum amino acid levels (HP:0003112)	2.47564058
23	Epidermoid cyst (HP:0200040)	2.47445251
24	Myelomeningocele (HP:0002475)	2.45727765
25	Increased serum lactate (HP:0002151)	2.45602995
26	Chronic bronchitis (HP:0004469)	2.44808828
27	Acute encephalopathy (HP:0006846)	2.43419668
28	Hypokalemia (HP:0002900)	2.40786862
29	Ulnar claw (HP:0001178)	2.40331229
30	Abolished electroretinogram (ERG) (HP:0000550)	2.39637474
31	Hepatocellular necrosis (HP:0001404)	2.39113864
32	Pancreatic fibrosis (HP:0100732)	2.39008454
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.37665265
34	Hepatic necrosis (HP:0002605)	2.37199164
35	Exocrine pancreatic insufficiency (HP:0001738)	2.36406164
36	Hypoproteinemia (HP:0003075)	2.36293611
37	Abnormality of serine family amino acid metabolism (HP:0010894)	2.34240388
38	Abnormality of glycine metabolism (HP:0010895)	2.34240388
39	Lactic acidosis (HP:0003128)	2.31360387
40	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31324085
41	Pendular nystagmus (HP:0012043)	2.30971566
42	Metabolic acidosis (HP:0001942)	2.30153481
43	Type II lissencephaly (HP:0007260)	2.28866091
44	Increased CSF lactate (HP:0002490)	2.26665077
45	Hypokalemic alkalosis (HP:0001949)	2.25206392
46	Abnormal biliary tract physiology (HP:0012439)	2.23401246
47	Bile duct proliferation (HP:0001408)	2.23401246
48	Gait imbalance (HP:0002141)	2.21947719
49	Type I transferrin isoform profile (HP:0003642)	2.21264794
50	Abnormality of glycolysis (HP:0004366)	2.20596702
51	Reduced antithrombin III activity (HP:0001976)	2.20572226
52	Mitochondrial inheritance (HP:0001427)	2.19897526
53	Acute necrotizing encephalopathy (HP:0006965)	2.19703057
54	Nephrogenic diabetes insipidus (HP:0009806)	2.19351531
55	Lissencephaly (HP:0001339)	2.18004946
56	Ketoacidosis (HP:0001993)	2.16830908
57	Hyperlipoproteinemia (HP:0010980)	2.15556386
58	Brushfield spots (HP:0001088)	2.14224409
59	Multiple enchondromatosis (HP:0005701)	2.13314152
60	Congenital primary aphakia (HP:0007707)	2.10966655
61	Neonatal respiratory distress (HP:0002643)	2.10733945
62	Recurrent corneal erosions (HP:0000495)	2.09930021
63	Horizontal nystagmus (HP:0000666)	2.09287628
64	Congenital stationary night blindness (HP:0007642)	2.09060425
65	Chorioretinal atrophy (HP:0000533)	2.08858142
66	Dicarboxylic aciduria (HP:0003215)	2.05961694
67	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.05961694
68	Vaginal atresia (HP:0000148)	2.05359978
69	Global brain atrophy (HP:0002283)	2.05330066
70	Hyperammonemia (HP:0001987)	2.04751583
71	Confusion (HP:0001289)	2.04731345
72	Medial flaring of the eyebrow (HP:0010747)	2.03261890
73	Anencephaly (HP:0002323)	2.02424964
74	Bilateral sensorineural hearing impairment (HP:0008619)	2.01380978
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00326202
76	Genital tract atresia (HP:0001827)	1.99871481
77	Alkalosis (HP:0001948)	1.97883799
78	Hyperactive renin-angiotensin system (HP:0000841)	1.95463906
79	Large for gestational age (HP:0001520)	1.95396508
80	Abnormal drinking behavior (HP:0030082)	1.94645327
81	Polydipsia (HP:0001959)	1.94645327
82	Abnormality of vitamin metabolism (HP:0100508)	1.94148288
83	Epiphyseal stippling (HP:0010655)	1.92061331
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.91599845
85	Optic disc pallor (HP:0000543)	1.90903975
86	Bicornuate uterus (HP:0000813)	1.90681909
87	Increased intramyocellular lipid droplets (HP:0012240)	1.89794026
88	Hyperkalemia (HP:0002153)	1.89692909
89	Lethargy (HP:0001254)	1.89438112
90	Renal Fanconi syndrome (HP:0001994)	1.89273995
91	Progressive macrocephaly (HP:0004481)	1.87303318
92	Unilateral renal agenesis (HP:0000122)	1.87029401
93	Abnormality of macular pigmentation (HP:0008002)	1.86938257
94	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.85066771
95	Abnormality of renin-angiotensin system (HP:0000847)	1.84541147
96	Ketosis (HP:0001946)	1.81445285
97	Decreased central vision (HP:0007663)	1.80483279
98	Abnormality of the pubic bones (HP:0003172)	1.80241334
99	Abnormality of potassium homeostasis (HP:0011042)	1.76345838
100	IgM deficiency (HP:0002850)	1.75707579

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	4.22852609
2	FRK	4.03187058
3	INSRR	3.68032539
4	SIK2	2.98471720
5	VRK2	2.83642254
6	PDK2	2.55838062
7	MAP3K12	2.46118187
8	NEK9	2.42110865
9	PNCK	2.21382054
10	CCNB1	2.12003062
11	MAPKAPK3	2.05784106
12	ADRBK2	2.00690061
13	ZAK	1.87354579
14	PIK3CG	1.84636336
15	MAP4K2	1.82734310
16	PRKD3	1.82243855
17	GRK1	1.53359595
18	TEC	1.52542487
19	TLK1	1.48811983
20	WNK4	1.42226251
21	PIM2	1.41396585
22	NEK1	1.39788303
23	NUAK1	1.38875947
24	TAOK3	1.35268379
25	PINK1	1.34054520
26	MAPKAPK5	1.31615519
27	OBSCN	1.28273547
28	MAP4K1	1.26795756
29	KDR	1.25767699
30	MST4	1.21850155
31	STK38L	1.17991868
32	CSNK1G3	1.17459342
33	EPHA4	1.17033972
34	TSSK6	1.16579208
35	MAPK13	1.15795352
36	MAP3K11	1.13445043
37	MARK1	1.07697198
38	OXSR1	1.07260376
39	PHKG1	1.06585230
40	PHKG2	1.06585230
41	TNK2	1.05256985
42	VRK1	1.00607791
43	ITK	1.00376186
44	SIK3	0.96316007
45	RPS6KA5	0.91181491
46	CDC7	0.87149838
47	BCKDK	0.86300825
48	MUSK	0.86133460
49	DYRK2	0.85525238
50	CSNK1G2	0.82743174
51	CSNK1A1L	0.80792625
52	TAF1	0.75868003
53	CSNK1G1	0.75413693
54	MAP2K7	0.72384714
55	PRKCQ	0.71960363
56	MINK1	0.70177867
57	DAPK3	0.69409082
58	PRKCG	0.67535133
59	LIMK1	0.65767790
60	ERBB3	0.64748581
61	ADRBK1	0.62873297
62	NEK2	0.56140456
63	NME1	0.55806832
64	STK38	0.52948449
65	GRK5	0.50606152
66	AKT2	0.50246781
67	MAP3K5	0.49792352
68	PRKAA1	0.49777457
69	PTK2B	0.49257106
70	PRKAA2	0.49228726
71	EPHA3	0.48477721
72	DAPK1	0.48469375
73	CAMK2A	0.48344148
74	IGF1R	0.47093539
75	PRKG2	0.45711803
76	MYLK	0.45042202
77	FLT3	0.44183669
78	LCK	0.44168261
79	CDK9	0.43631375
80	MAPK15	0.41432738
81	NEK6	0.41248331
82	CAMK1G	0.40647213
83	PRKCE	0.40639038
84	PRKACA	0.39872849
85	MKNK1	0.39686109
86	CSNK1A1	0.38656908
87	NTRK1	0.37635002
88	SYK	0.37263202
89	PASK	0.36687721
90	CAMK4	0.35591505
91	TBK1	0.35556050
92	AURKA	0.32970818
93	PRKCA	0.32787798
94	PRKG1	0.32691895
95	PBK	0.32060343
96	GRK6	0.31073578
97	ABL1	0.30533255
98	EPHB1	0.29004175
99	TRPM7	0.27724916
100	PLK1	0.27706742

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Steroid biosynthesis_Homo sapiens_hsa00100	3.08766864
2	Selenocompound metabolism_Homo sapiens_hsa00450	3.00480812
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.95512496
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.59646231
5	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.50049784
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.42242770
7	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.39549558
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.15172003
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.03813379
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.03410615
11	Butanoate metabolism_Homo sapiens_hsa00650	2.03320390
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.95057304
13	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.92204145
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.91245229
15	Proteasome_Homo sapiens_hsa03050	1.89339239
16	Peroxisome_Homo sapiens_hsa04146	1.88929167
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.83461153
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.80255980
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.79453125
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.64923389
21	Sulfur metabolism_Homo sapiens_hsa00920	1.63289764
22	Propanoate metabolism_Homo sapiens_hsa00640	1.54584510
23	Pyruvate metabolism_Homo sapiens_hsa00620	1.53039004
24	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.52132533
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.49643803
26	Sulfur relay system_Homo sapiens_hsa04122	1.49379309
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.48758606
28	Retinol metabolism_Homo sapiens_hsa00830	1.48078761
29	Protein export_Homo sapiens_hsa03060	1.46562159
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43907690
31	Parkinsons disease_Homo sapiens_hsa05012	1.41162010
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.30800566
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.27790343
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.24935474
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.21216485
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.19208496
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.18608640
38	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.17968640
39	Arginine biosynthesis_Homo sapiens_hsa00220	1.16218492
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.15617801
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.15591220
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.14175794
43	One carbon pool by folate_Homo sapiens_hsa00670	1.12176646
44	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.11891036
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.09144330
46	Carbon metabolism_Homo sapiens_hsa01200	1.08504441
47	Fatty acid elongation_Homo sapiens_hsa00062	1.05317610
48	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.05242548
49	Phototransduction_Homo sapiens_hsa04744	1.04394693
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02134268
51	Nicotine addiction_Homo sapiens_hsa05033	1.00502865
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.97295678
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95168281
54	Huntingtons disease_Homo sapiens_hsa05016	0.94597603
55	Olfactory transduction_Homo sapiens_hsa04740	0.94176277
56	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.93671346
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.93310516
58	RNA polymerase_Homo sapiens_hsa03020	0.93192496
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.92101218
60	Taste transduction_Homo sapiens_hsa04742	0.90722018
61	Basal transcription factors_Homo sapiens_hsa03022	0.88314997
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.87174564
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.85714725
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.84779159
65	Bile secretion_Homo sapiens_hsa04976	0.83453368
66	Alzheimers disease_Homo sapiens_hsa05010	0.83013483
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79589727
68	Fatty acid degradation_Homo sapiens_hsa00071	0.78256541
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77041243
70	Metabolic pathways_Homo sapiens_hsa01100	0.75886618
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.67419396
72	Non-homologous end-joining_Homo sapiens_hsa03450	0.67405155
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.64069839
74	GABAergic synapse_Homo sapiens_hsa04727	0.63407187
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63354109
76	Pentose phosphate pathway_Homo sapiens_hsa00030	0.62367480
77	Alcoholism_Homo sapiens_hsa05034	0.60895139
78	Phenylalanine metabolism_Homo sapiens_hsa00360	0.57562109
79	Caffeine metabolism_Homo sapiens_hsa00232	0.55422408
80	Homologous recombination_Homo sapiens_hsa03440	0.54913247
81	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.51028449
82	Folate biosynthesis_Homo sapiens_hsa00790	0.50412263
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.49944205
84	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.48605455
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47920434
86	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.47401352
87	Morphine addiction_Homo sapiens_hsa05032	0.46424695
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45335398
89	Complement and coagulation cascades_Homo sapiens_hsa04610	0.43098774
90	PPAR signaling pathway_Homo sapiens_hsa03320	0.41152528
91	ABC transporters_Homo sapiens_hsa02010	0.40938120
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.39196361
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.37778623
94	Antigen processing and presentation_Homo sapiens_hsa04612	0.37640447
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.34008311
96	Glutathione metabolism_Homo sapiens_hsa00480	0.33179452
97	Serotonergic synapse_Homo sapiens_hsa04726	0.31883572
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.30345865
99	Purine metabolism_Homo sapiens_hsa00230	0.29409376
100	Fanconi anemia pathway_Homo sapiens_hsa03460	0.29110056

CYP51A1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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