ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	8.40885049
2	muscle organ morphogenesis (GO:0048644)	6.88499886
3	ear development (GO:0043583)	6.45041131
4	regulation of somitogenesis (GO:0014807)	6.39279492
5	embryonic heart tube development (GO:0035050)	6.07464890
6	positive regulation of gastrulation (GO:2000543)	5.53432254
7	regulation of glucokinase activity (GO:0033131)	5.11822715
8	regulation of hexokinase activity (GO:1903299)	5.11822715
9	organelle membrane fusion (GO:0090174)	5.03328703
10	neuromuscular process controlling posture (GO:0050884)	4.80308491
11	positive regulation of vesicle fusion (GO:0031340)	4.67098300
12	magnesium ion transport (GO:0015693)	4.66319420
13	autophagic vacuole fusion (GO:0000046)	4.65454365
14	lymphangiogenesis (GO:0001946)	4.64646087
15	mesenchymal to epithelial transition (GO:0060231)	4.59531475
16	positive regulation of embryonic development (GO:0040019)	4.53530504
17	pyrimidine dimer repair (GO:0006290)	4.38249336
18	cysteine metabolic process (GO:0006534)	4.35819392
19	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	4.32401675
20	regulation of apoptotic process involved in morphogenesis (GO:1902337)	4.25955918
21	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	4.25014891
22	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.14457245
23	nitric oxide mediated signal transduction (GO:0007263)	4.12058136
24	endocardial cushion development (GO:0003197)	4.10859495
25	nucleoside diphosphate phosphorylation (GO:0006165)	4.08087168
26	regulation of stem cell maintenance (GO:2000036)	4.07263824
27	paraxial mesoderm development (GO:0048339)	4.05830032
28	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	4.01767664
29	peptide catabolic process (GO:0043171)	3.99958184
30	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.96935779
31	nephron tubule formation (GO:0072079)	3.91455326
32	positive regulation of prostaglandin secretion (GO:0032308)	3.89360077
33	establishment of endothelial barrier (GO:0061028)	3.82219047
34	axoneme assembly (GO:0035082)	3.80765168
35	establishment of apical/basal cell polarity (GO:0035089)	3.72861768
36	pattern specification involved in kidney development (GO:0061004)	3.68933592
37	protein K11-linked deubiquitination (GO:0035871)	3.66510285
38	neural tube formation (GO:0001841)	3.60619169
39	ventricular system development (GO:0021591)	3.59549904
40	lens fiber cell development (GO:0070307)	3.56377856
41	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.54371445
42	prenylation (GO:0097354)	3.53132040
43	protein prenylation (GO:0018342)	3.53132040
44	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.52157903
45	cardiovascular system development (GO:0072358)	3.51134768
46	positive regulation of icosanoid secretion (GO:0032305)	3.49986015
47	positive regulation of fatty acid transport (GO:2000193)	3.48866067
48	endoderm formation (GO:0001706)	3.41175176
49	mRNA transcription from RNA polymerase II promoter (GO:0042789)	3.40259163
50	dopaminergic neuron differentiation (GO:0071542)	3.37686198
51	establishment of monopolar cell polarity (GO:0061162)	3.37440400
52	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.37440400
53	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.33794835
54	negative regulation of mast cell activation (GO:0033004)	3.33332240
55	polarized epithelial cell differentiation (GO:0030859)	3.26877301
56	signal transduction involved in regulation of gene expression (GO:0023019)	3.20260997
57	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.18668873
58	mRNA transcription (GO:0009299)	3.16863983
59	ubiquinone biosynthetic process (GO:0006744)	3.16721637
60	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.16273483
61	regulation of prostaglandin secretion (GO:0032306)	3.15078906
62	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.14810974
63	ventricular septum development (GO:0003281)	3.14016783
64	positive regulation of fatty acid oxidation (GO:0046321)	3.11942244
65	multicellular organism reproduction (GO:0032504)	3.08720427
66	ubiquinone metabolic process (GO:0006743)	3.02405907
67	regulation of establishment of cell polarity (GO:2000114)	3.00274570
68	serine family amino acid biosynthetic process (GO:0009070)	2.99884264
69	embryonic epithelial tube formation (GO:0001838)	2.98618561
70	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	2.97277342
71	cilium or flagellum-dependent cell motility (GO:0001539)	2.92590228
72	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.91712393
73	eating behavior (GO:0042755)	2.87159067
74	regulation of respiratory system process (GO:0044065)	2.86399367
75	epithelial tube formation (GO:0072175)	2.84645523
76	RNA destabilization (GO:0050779)	2.79966177
77	endothelial cell development (GO:0001885)	2.76153187
78	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.74025415
79	mesonephros development (GO:0001823)	2.73890425
80	hyperosmotic salinity response (GO:0042538)	2.72583415
81	protein-cofactor linkage (GO:0018065)	2.70646232
82	establishment of epithelial cell polarity (GO:0090162)	2.70078846
83	interferon-gamma secretion (GO:0072643)	2.68095104
84	acrosome assembly (GO:0001675)	2.66122032
85	primary amino compound metabolic process (GO:1901160)	2.65740185
86	parturition (GO:0007567)	2.64912578
87	alanine transport (GO:0032328)	2.64614674
88	regulation of fatty acid oxidation (GO:0046320)	2.63279445
89	nodal signaling pathway (GO:0038092)	2.61506031
90	positive regulation by host of viral transcription (GO:0043923)	2.61200725
91	lymph node development (GO:0048535)	2.59945784
92	regulation of organ formation (GO:0003156)	2.59830246
93	piRNA metabolic process (GO:0034587)	2.58618368
94	ovulation from ovarian follicle (GO:0001542)	2.57665491
95	regulation of gastrulation (GO:0010470)	2.57086036
96	fusion of sperm to egg plasma membrane (GO:0007342)	2.56560899
97	type B pancreatic cell development (GO:0003323)	2.54130954
98	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.51469509
99	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.50885105
100	neuronal action potential (GO:0019228)	2.50649961

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.15120571
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.79492923
3	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	4.34315478
4	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	4.34315478
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	4.34315478
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.21689897
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.09605955
8	VDR_22108803_ChIP-Seq_LS180_Human	2.99849589
9	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.80207333
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42136672
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.05973219
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.02445182
13	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.90208687
14	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.79258710
15	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.78808472
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76627148
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72000808
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.69591614
19	P300_19829295_ChIP-Seq_ESCs_Human	1.66749938
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.64693592
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56678770
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.56434696
23	TP53_16413492_ChIP-PET_HCT116_Human	1.53141144
24	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.51358447
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.48929833
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.42912895
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42801622
28	TCF4_22108803_ChIP-Seq_LS180_Human	1.38382514
29	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37596421
30	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37596421
31	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.36705777
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35418142
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35358928
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35282402
35	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.30977137
36	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.29949055
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27088396
38	EGR1_19032775_ChIP-ChIP_M12_Human	1.26950991
39	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.25933110
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.25228113
41	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.25194258
42	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.25180523
43	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24930422
44	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.24506289
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.24143075
46	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.23778757
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.21629315
48	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21512227
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21512227
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.21493975
51	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.21149309
52	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19278060
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.18788141
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16454364
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16063304
56	GBX2_23144817_ChIP-Seq_PC3_Human	1.16009813
57	EWS_26573619_Chip-Seq_HEK293_Human	1.15838171
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.15823613
59	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15771091
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15246706
61	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.14691863
62	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.14592566
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14388062
64	AR_25329375_ChIP-Seq_VCAP_Human	1.10598281
65	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.09284417
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09259253
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.08818382
68	ERA_21632823_ChIP-Seq_H3396_Human	1.08809258
69	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.07496497
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.05495666
71	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04699163
72	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.04107706
73	TCF4_23295773_ChIP-Seq_U87_Human	1.03116420
74	FUS_26573619_Chip-Seq_HEK293_Human	1.03013813
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02570608
76	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.02562266
77	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.01358617
78	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.01262340
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01240636
80	STAT3_23295773_ChIP-Seq_U87_Human	0.98786908
81	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.96324041
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95602894
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95057327
84	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.94842002
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94364812
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93087372
87	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.92563926
88	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.92411960
89	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92230761
90	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.92155097
91	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.91392861
92	IRF1_19129219_ChIP-ChIP_H3396_Human	0.91080560
93	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.90965951
94	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.90470544
95	SMAD4_21799915_ChIP-Seq_A2780_Human	0.89726219
96	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.89188074
97	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.89088088
98	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.88494658
99	NANOG_19829295_ChIP-Seq_ESCs_Human	0.86257259
100	SOX2_19829295_ChIP-Seq_ESCs_Human	0.86257259

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	6.00606899
2	MP0010386_abnormal_urinary_bladder	4.07387571
3	MP0003183_abnormal_peptide_metabolism	4.01158433
4	MP0002277_abnormal_respiratory_mucosa	3.94184640
5	MP0003941_abnormal_skin_development	3.83536467
6	MP0006054_spinal_hemorrhage	3.44857516
7	MP0003136_yellow_coat_color	3.27938552
8	MP0001879_abnormal_lymphatic_vessel	3.01803087
9	MP0002089_abnormal_postnatal_growth/wei	2.85127869
10	MP0004133_heterotaxia	2.71309189
11	MP0010030_abnormal_orbit_morphology	2.45737868
12	MP0005409_darkened_coat_color	2.42611091
13	MP0002876_abnormal_thyroid_physiology	2.28911563
14	MP0001299_abnormal_eye_distance/	2.12786446
15	MP0001502_abnormal_circadian_rhythm	2.10281783
16	MP0005257_abnormal_intraocular_pressure	2.05478891
17	MP0002160_abnormal_reproductive_system	2.05339208
18	MP0001346_abnormal_lacrimal_gland	2.05214799
19	MP0005503_abnormal_tendon_morphology	1.95983708
20	MP0009384_cardiac_valve_regurgitation	1.91127147
21	MP0008995_early_reproductive_senescence	1.84612570
22	MP0004043_abnormal_pH_regulation	1.83470498
23	MP0002177_abnormal_outer_ear	1.71086223
24	MP0000733_abnormal_muscle_development	1.69224510
25	MP0002638_abnormal_pupillary_reflex	1.54945391
26	MP0002138_abnormal_hepatobiliary_system	1.51662455
27	MP0005389_reproductive_system_phenotype	1.46812294
28	MP0002928_abnormal_bile_duct	1.44376618
29	MP0005083_abnormal_biliary_tract	1.42060702
30	MP0003879_abnormal_hair_cell	1.41065903
31	MP0003937_abnormal_limbs/digits/tail_de	1.38547857
32	MP0002396_abnormal_hematopoietic_system	1.37575580
33	MP0008877_abnormal_DNA_methylation	1.36075682
34	MP0003195_calcinosis	1.26720075
35	MP0009250_abnormal_appendicular_skeleto	1.24444813
36	MP0008875_abnormal_xenobiotic_pharmacok	1.24434762
37	MP0002282_abnormal_trachea_morphology	1.22570651
38	MP0005646_abnormal_pituitary_gland	1.21777113
39	MP0005084_abnormal_gallbladder_morpholo	1.21662561
40	MP0005187_abnormal_penis_morphology	1.21242851
41	MP0002098_abnormal_vibrissa_morphology	1.19663876
42	MP0010352_gastrointestinal_tract_polyps	1.16432966
43	MP0000631_abnormal_neuroendocrine_gland	1.15812335
44	MP0003252_abnormal_bile_duct	1.14546891
45	MP0002075_abnormal_coat/hair_pigmentati	1.14351972
46	MP0008789_abnormal_olfactory_epithelium	1.14351708
47	MP0003938_abnormal_ear_development	1.14039656
48	MP0005085_abnormal_gallbladder_physiolo	1.12645133
49	MP0001485_abnormal_pinna_reflex	1.11067180
50	MP0002735_abnormal_chemical_nociception	1.06230958
51	MP0002009_preneoplasia	1.05904174
52	MP0003950_abnormal_plasma_membrane	1.05480150
53	MP0009046_muscle_twitch	1.01989576
54	MP0005394_taste/olfaction_phenotype	1.01833087
55	MP0005499_abnormal_olfactory_system	1.01833087
56	MP0003646_muscle_fatigue	1.00870053
57	MP0002736_abnormal_nociception_after	1.00217593
58	MP0000371_diluted_coat_color	0.98902559
59	MP0004019_abnormal_vitamin_homeostasis	0.91317272
60	MP0005197_abnormal_uvea_morphology	0.89066830
61	MP0005508_abnormal_skeleton_morphology	0.87987632
62	MP0001905_abnormal_dopamine_level	0.86858676
63	MP0002127_abnormal_cardiovascular_syste	0.85853706
64	MP0008961_abnormal_basal_metabolism	0.84765604
65	MP0001919_abnormal_reproductive_system	0.84639116
66	MP0005647_abnormal_sex_gland	0.83894118
67	MP0001186_pigmentation_phenotype	0.83462249
68	MP0008872_abnormal_physiological_respon	0.83201540
69	MP0001968_abnormal_touch/_nociception	0.83100610
70	MP0002111_abnormal_tail_morphology	0.82582744
71	MP0005645_abnormal_hypothalamus_physiol	0.81918025
72	MP0000685_abnormal_immune_system	0.81883203
73	MP0005410_abnormal_fertilization	0.81119478
74	MP0000534_abnormal_ureter_morphology	0.79925582
75	MP0002909_abnormal_adrenal_gland	0.79524402
76	MP0002733_abnormal_thermal_nociception	0.79110020
77	MP0002734_abnormal_mechanical_nocicepti	0.78666637
78	MP0001270_distended_abdomen	0.75407041
79	MP0003936_abnormal_reproductive_system	0.73179793
80	MP0002233_abnormal_nose_morphology	0.72550385
81	MP0001324_abnormal_eye_pigmentation	0.71835211
82	MP0003633_abnormal_nervous_system	0.71580844
83	MP0000613_abnormal_salivary_gland	0.71305775
84	MP0002116_abnormal_craniofacial_bone	0.70998358
85	MP0000003_abnormal_adipose_tissue	0.70484557
86	MP0005551_abnormal_eye_electrophysiolog	0.70417992
87	MP0005171_absent_coat_pigmentation	0.67839461
88	MP0000049_abnormal_middle_ear	0.65266542
89	MP0003942_abnormal_urinary_system	0.64329514
90	MP0008775_abnormal_heart_ventricle	0.62897327
91	MP0003718_maternal_effect	0.60248035
92	MP0003045_fibrosis	0.58967046
93	MP0000428_abnormal_craniofacial_morphol	0.58907379
94	MP0000762_abnormal_tongue_morphology	0.57845294
95	MP0001881_abnormal_mammary_gland	0.56714687
96	MP0009745_abnormal_behavioral_response	0.56561069
97	MP0002272_abnormal_nervous_system	0.55976384
98	MP0002249_abnormal_larynx_morphology	0.55725691
99	MP0000639_abnormal_adrenal_gland	0.54332304
100	MP0000230_abnormal_systemic_arterial	0.53944165

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplastic ischia (HP:0003175)	5.43353705
2	Fibular aplasia (HP:0002990)	5.14351909
3	Bell-shaped thorax (HP:0001591)	5.13459916
4	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	4.96526842
5	Abnormality of the ischium (HP:0003174)	4.83493561
6	Mesomelia (HP:0003027)	4.65098344
7	Hypomagnesemia (HP:0002917)	4.61926811
8	Tetany (HP:0001281)	4.55822584
9	Abnormal drinking behavior (HP:0030082)	4.41197720
10	Polydipsia (HP:0001959)	4.41197720
11	2-3 toe syndactyly (HP:0004691)	4.27291803
12	Nonimmune hydrops fetalis (HP:0001790)	4.26851349
13	Long clavicles (HP:0000890)	4.20081339
14	Wrist flexion contracture (HP:0001239)	4.10162982
15	Stomach cancer (HP:0012126)	3.74193243
16	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.67856675
17	Abnormality of magnesium homeostasis (HP:0004921)	3.64790423
18	Abnormality of the pubic bones (HP:0003172)	3.63960188
19	Lymphangioma (HP:0100764)	3.59212558
20	Type I diabetes mellitus (HP:0100651)	3.48105879
21	Abnormal finger flexion creases (HP:0006143)	3.17964484
22	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.10751753
23	Absent eyebrow (HP:0002223)	3.03429158
24	Cutaneous finger syndactyly (HP:0010554)	2.99956385
25	Nonprogressive disorder (HP:0003680)	2.94887649
26	Absent phalangeal crease (HP:0006109)	2.93881881
27	Abnormality of the columella (HP:0009929)	2.93544858
28	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.93463695
29	Birth length less than 3rd percentile (HP:0003561)	2.69340012
30	Polyuria (HP:0000103)	2.68014745
31	Pancreatic fibrosis (HP:0100732)	2.67373515
32	Pendular nystagmus (HP:0012043)	2.63070436
33	Split foot (HP:0001839)	2.61056734
34	Anencephaly (HP:0002323)	2.54968252
35	Microglossia (HP:0000171)	2.53854641
36	Hypothermia (HP:0002045)	2.52857386
37	Hypoplastic iliac wings (HP:0002866)	2.52468339
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.51814004
39	Microtia (HP:0008551)	2.51096111
40	Thyroid-stimulating hormone excess (HP:0002925)	2.49885571
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.49322808
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.49322808
43	Cupped ear (HP:0000378)	2.48169225
44	Decreased central vision (HP:0007663)	2.48025466
45	Alveolar cell carcinoma (HP:0006519)	2.47393121
46	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.44839999
47	Gaze-evoked nystagmus (HP:0000640)	2.43123839
48	Venous insufficiency (HP:0005293)	2.42951886
49	Late onset (HP:0003584)	2.38348829
50	Tubular atrophy (HP:0000092)	2.34274724
51	Renal tubular acidosis (HP:0001947)	2.31562345
52	Cutaneous syndactyly (HP:0012725)	2.30373464
53	Absent hair (HP:0002298)	2.26601474
54	Pancreatic cysts (HP:0001737)	2.21629522
55	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.20134273
56	Abnormality of alanine metabolism (HP:0010916)	2.20134273
57	Hyperalaninemia (HP:0003348)	2.20134273
58	Spinal muscular atrophy (HP:0007269)	2.20018145
59	Aplasia of the musculature (HP:0100854)	2.18457737
60	Neoplasm of the tracheobronchial system (HP:0100552)	2.17360759
61	Cleft eyelid (HP:0000625)	2.15086778
62	Abnormal urine output (HP:0012590)	2.15082489
63	Aplasia/Hypoplasia of the scapulae (HP:0006713)	2.13772055
64	Hypoplastic scapulae (HP:0000882)	2.13772055
65	Barrel-shaped chest (HP:0001552)	2.13617297
66	True hermaphroditism (HP:0010459)	2.12552902
67	Diastasis recti (HP:0001540)	2.11701506
68	Breast aplasia (HP:0100783)	2.10860762
69	Palpebral edema (HP:0100540)	2.10451388
70	Abnormality of the middle phalanges of the toes (HP:0010183)	2.06288846
71	Depressed nasal tip (HP:0000437)	2.05165044
72	Anhidrosis (HP:0000970)	2.04904784
73	Concave nail (HP:0001598)	2.01489619
74	Conical tooth (HP:0000698)	2.00050128
75	Facial edema (HP:0000282)	1.95147836
76	Absent eyelashes (HP:0000561)	1.95110306
77	Periorbital edema (HP:0100539)	1.94927654
78	Rhinitis (HP:0012384)	1.93390691
79	Abnormality of renal excretion (HP:0011036)	1.93272464
80	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92316771
81	Increased corneal curvature (HP:0100692)	1.91686454
82	Keratoconus (HP:0000563)	1.91686454
83	Congenital hepatic fibrosis (HP:0002612)	1.89513399
84	Chronic bronchitis (HP:0004469)	1.86569128
85	Hypercalciuria (HP:0002150)	1.85959655
86	Adactyly (HP:0009776)	1.85268417
87	Hyperuricemia (HP:0002149)	1.85203879
88	Increased purine levels (HP:0004368)	1.85203879
89	Subacute progressive viral hepatitis (HP:0006572)	1.84190307
90	Nephritis (HP:0000123)	1.81245971
91	Abnormal respiratory motile cilium physiology (HP:0012261)	1.80794895
92	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.80264904
93	Patellar aplasia (HP:0006443)	1.79500681
94	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.78607361
95	Prominent supraorbital ridges (HP:0000336)	1.77360755
96	Hyperthyroidism (HP:0000836)	1.76946369
97	Aplasia/Hypoplasia of the breasts (HP:0010311)	1.76280377
98	Furrowed tongue (HP:0000221)	1.76186632
99	Hypotrichosis (HP:0001006)	1.75428387
100	Abnormality of the antihelix (HP:0009738)	1.75174634

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	5.17713759
2	TAOK3	4.76602657
3	MAP3K10	4.38718057
4	MAP2K7	3.72695200
5	PNCK	3.40616739
6	FRK	3.03046897
7	PINK1	3.02128095
8	INSRR	2.96675593
9	BRSK2	2.70015222
10	STK24	2.29044669
11	NUAK1	2.20094818
12	MKNK2	2.11402027
13	CSF1R	1.72846135
14	CCNB1	1.67710627
15	MAPK15	1.59671803
16	IRAK1	1.53513308
17	LIMK1	1.51361281
18	WNK3	1.51167238
19	PAK3	1.41728291
20	STK3	1.36911519
21	ADRBK2	1.30951067
22	NEK6	1.28115591
23	MAPKAPK3	1.28055709
24	NEK9	1.25384975
25	NEK2	1.24464443
26	ACVR1B	1.21937443
27	BMPR1B	1.21383995
28	PKN2	1.21264468
29	DMPK	1.18721616
30	GRK1	1.16468583
31	TLK1	1.11813849
32	RPS6KA4	1.07561283
33	MAP4K2	1.05919071
34	MKNK1	1.01600437
35	MAP3K14	0.98184265
36	TAOK1	0.92968807
37	RPS6KB2	0.82639437
38	PDK1	0.81756020
39	ADRBK1	0.80742249
40	MELK	0.78646440
41	PRKCI	0.77864806
42	IKBKE	0.77557216
43	MUSK	0.77029650
44	WNK4	0.75068503
45	PRKCG	0.74863353
46	PRKCQ	0.72089927
47	PDPK1	0.71122867
48	MARK3	0.70860198
49	PKN1	0.70793820
50	MAPK12	0.70232168
51	CHUK	0.67315510
52	MAP3K5	0.64537861
53	ZAK	0.63641568
54	WEE1	0.63599878
55	PLK3	0.62340058
56	IKBKB	0.61452537
57	TGFBR1	0.59312871
58	PTK6	0.59022612
59	TEC	0.58854079
60	CSNK1A1	0.58728001
61	PRKAA2	0.58316921
62	MAP3K13	0.55569559
63	PTK2B	0.55443456
64	MAP3K4	0.54622400
65	PLK2	0.54240908
66	PLK1	0.52443374
67	CDK3	0.51940635
68	CAMK2A	0.50908920
69	CHEK2	0.48863786
70	TBK1	0.48062787
71	BRSK1	0.47116467
72	EIF2AK2	0.47099614
73	TTK	0.45134340
74	DYRK1A	0.43640018
75	AKT3	0.40535679
76	TIE1	0.40094316
77	GSK3A	0.39003307
78	PRKCE	0.38676167
79	SGK1	0.38002228
80	STK39	0.37532908
81	CAMK1G	0.37502319
82	STK38L	0.36978991
83	IGF1R	0.35461876
84	EIF2AK3	0.35440700
85	CDC7	0.35268211
86	PIM1	0.34712490
87	MAP3K3	0.34360284
88	PIK3CA	0.33022228
89	MAPK13	0.30708265
90	CAMK1	0.30550345
91	IRAK4	0.30491460
92	MET	0.29578741
93	TESK1	0.27947787
94	ILK	0.27002368
95	RPS6KB1	0.26732414
96	FGFR1	0.26318044
97	TRIB3	0.25911878
98	FGFR2	0.25745772
99	DYRK3	0.25528990
100	MYLK	0.24428447

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	6.11152397
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	5.22919841
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.32726955
4	Caffeine metabolism_Homo sapiens_hsa00232	2.39714086
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.16535759
6	Sulfur relay system_Homo sapiens_hsa04122	2.07102165
7	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.05134987
8	Basal transcription factors_Homo sapiens_hsa03022	2.01984990
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.98082886
10	Propanoate metabolism_Homo sapiens_hsa00640	1.95548734
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.77303152
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.75945437
13	Phototransduction_Homo sapiens_hsa04744	1.65350709
14	Circadian entrainment_Homo sapiens_hsa04713	1.60562485
15	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.55618019
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.52435034
17	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.42871367
18	Homologous recombination_Homo sapiens_hsa03440	1.41841828
19	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.36698442
20	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.34038725
21	Taste transduction_Homo sapiens_hsa04742	1.31487877
22	Salivary secretion_Homo sapiens_hsa04970	1.29510536
23	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.28470944
24	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.26079457
25	ABC transporters_Homo sapiens_hsa02010	1.25952672
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.25615401
27	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.24479625
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.20177751
29	African trypanosomiasis_Homo sapiens_hsa05143	1.19969129
30	Retinol metabolism_Homo sapiens_hsa00830	1.17795977
31	Nicotine addiction_Homo sapiens_hsa05033	1.16623511
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.15709124
33	Tight junction_Homo sapiens_hsa04530	1.11872314
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.09979550
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09748537
36	Hepatitis C_Homo sapiens_hsa05160	1.08913164
37	Other glycan degradation_Homo sapiens_hsa00511	1.05292115
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.01380663
39	Olfactory transduction_Homo sapiens_hsa04740	0.99301966
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98584472
41	Histidine metabolism_Homo sapiens_hsa00340	0.95690734
42	p53 signaling pathway_Homo sapiens_hsa04115	0.94938871
43	Fatty acid degradation_Homo sapiens_hsa00071	0.94347544
44	Pyruvate metabolism_Homo sapiens_hsa00620	0.94073584
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93681588
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89229061
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88045350
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.87649741
49	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.87059223
50	Serotonergic synapse_Homo sapiens_hsa04726	0.86766085
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.86561125
52	Protein export_Homo sapiens_hsa03060	0.83753789
53	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.83262167
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.81270693
55	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.80000750
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78564027
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.74238044
58	Amphetamine addiction_Homo sapiens_hsa05031	0.69390111
59	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.66886902
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66225959
61	Cocaine addiction_Homo sapiens_hsa05030	0.66189976
62	Glutamatergic synapse_Homo sapiens_hsa04724	0.66131178
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62987560
64	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.62370571
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62004936
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61442617
67	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.61208372
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60575988
69	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60514836
70	Phenylalanine metabolism_Homo sapiens_hsa00360	0.60417644
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.57779873
72	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56450163
73	Circadian rhythm_Homo sapiens_hsa04710	0.56412105
74	Galactose metabolism_Homo sapiens_hsa00052	0.55517525
75	Morphine addiction_Homo sapiens_hsa05032	0.54866253
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54813093
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.53850327
78	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.52947010
79	Long-term depression_Homo sapiens_hsa04730	0.52468380
80	PPAR signaling pathway_Homo sapiens_hsa03320	0.50373582
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.48524464
82	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.48248000
83	TNF signaling pathway_Homo sapiens_hsa04668	0.46479407
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46035319
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.44715107
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42715250
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42562818
88	Pancreatic secretion_Homo sapiens_hsa04972	0.40914584
89	Purine metabolism_Homo sapiens_hsa00230	0.40357155
90	RNA polymerase_Homo sapiens_hsa03020	0.39876654
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38026274
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.36962794
93	Mineral absorption_Homo sapiens_hsa04978	0.36355920
94	Metabolic pathways_Homo sapiens_hsa01100	0.35205865
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.34699471
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34291842
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33138742
98	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.32943791
99	Huntingtons disease_Homo sapiens_hsa05016	0.32904936
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32601437

CYP51A1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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