CYP7A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.75453987
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.75453987
3L-phenylalanine metabolic process (GO:0006558)7.38792762
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.38792762
5aromatic amino acid family catabolic process (GO:0009074)6.94753201
6phenylpropanoid metabolic process (GO:0009698)6.55676574
7indole-containing compound catabolic process (GO:0042436)6.21634434
8indolalkylamine catabolic process (GO:0046218)6.21634434
9tryptophan catabolic process (GO:0006569)6.21634434
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.21468713
11oxidative demethylation (GO:0070989)6.14789628
12kynurenine metabolic process (GO:0070189)6.06526013
13urea metabolic process (GO:0019627)5.92450670
14urea cycle (GO:0000050)5.92450670
15tryptophan metabolic process (GO:0006568)5.86437809
16* bile acid biosynthetic process (GO:0006699)5.84802123
17omega-hydroxylase P450 pathway (GO:0097267)5.84231797
18glyoxylate metabolic process (GO:0046487)5.63344463
19alpha-linolenic acid metabolic process (GO:0036109)5.55216997
20negative regulation of fibrinolysis (GO:0051918)5.53198867
21high-density lipoprotein particle remodeling (GO:0034375)5.48756320
22nitrogen cycle metabolic process (GO:0071941)5.43910394
23peptidyl-glutamic acid carboxylation (GO:0017187)5.38265577
24protein carboxylation (GO:0018214)5.38265577
25regulation of fibrinolysis (GO:0051917)5.35302867
26sulfur amino acid catabolic process (GO:0000098)5.34318362
27complement activation, alternative pathway (GO:0006957)5.32471108
28cysteine metabolic process (GO:0006534)5.28117238
29regulation of protein activation cascade (GO:2000257)5.26555289
30serine family amino acid catabolic process (GO:0009071)5.14635889
31alkaloid metabolic process (GO:0009820)5.12523706
32* bile acid metabolic process (GO:0008206)5.05373052
33aromatic amino acid family metabolic process (GO:0009072)5.04303020
34ethanol metabolic process (GO:0006067)5.03091115
35homocysteine metabolic process (GO:0050667)5.01635195
36tyrosine metabolic process (GO:0006570)4.95104482
37regulation of complement activation (GO:0030449)4.93996910
38negative regulation of blood coagulation (GO:0030195)4.88470400
39negative regulation of hemostasis (GO:1900047)4.88470400
40hormone catabolic process (GO:0042447)4.80850037
41regulation of cholesterol esterification (GO:0010872)4.79416885
42regulation of plasminogen activation (GO:0010755)4.79081297
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.75899980
44reverse cholesterol transport (GO:0043691)4.73949066
45regulation of triglyceride catabolic process (GO:0010896)4.73693154
46alpha-amino acid catabolic process (GO:1901606)4.73638606
47protein-lipid complex remodeling (GO:0034368)4.71921731
48macromolecular complex remodeling (GO:0034367)4.71921731
49plasma lipoprotein particle remodeling (GO:0034369)4.71921731
50amino-acid betaine metabolic process (GO:0006577)4.69169546
51lysine metabolic process (GO:0006553)4.66493640
52lysine catabolic process (GO:0006554)4.66493640
53negative regulation of protein activation cascade (GO:2000258)4.66362695
54triglyceride homeostasis (GO:0070328)4.56358829
55acylglycerol homeostasis (GO:0055090)4.56358829
56negative regulation of wound healing (GO:0061045)4.56347504
57negative regulation of sterol transport (GO:0032372)4.54077042
58negative regulation of cholesterol transport (GO:0032375)4.54077042
59acute-phase response (GO:0006953)4.47913445
60coenzyme catabolic process (GO:0009109)4.46548548
61cellular glucuronidation (GO:0052695)4.46235875
62bile acid and bile salt transport (GO:0015721)4.45790385
63glycine metabolic process (GO:0006544)4.45507253
64negative regulation of coagulation (GO:0050819)4.44678539
65negative regulation of complement activation (GO:0045916)4.44566627
66phospholipid efflux (GO:0033700)4.43553683
67regulation of humoral immune response (GO:0002920)4.41460960
68indolalkylamine metabolic process (GO:0006586)4.41191580
69imidazole-containing compound metabolic process (GO:0052803)4.36803180
70cellular amino acid catabolic process (GO:0009063)4.34301641
71plasma lipoprotein particle clearance (GO:0034381)4.32872918
72amine catabolic process (GO:0009310)4.32681849
73cellular biogenic amine catabolic process (GO:0042402)4.32681849
74cellular ketone body metabolic process (GO:0046950)4.31717600
75glutamate metabolic process (GO:0006536)4.26784985
76drug catabolic process (GO:0042737)4.23215582
77serine family amino acid metabolic process (GO:0009069)4.18707147
78benzene-containing compound metabolic process (GO:0042537)4.17473147
79cholesterol efflux (GO:0033344)4.17461491
80arginine metabolic process (GO:0006525)4.13165203
81cellular modified amino acid catabolic process (GO:0042219)4.09108635
82ethanol oxidation (GO:0006069)4.08621739
83low-density lipoprotein particle remodeling (GO:0034374)4.06459926
84dicarboxylic acid biosynthetic process (GO:0043650)4.03254799
85fibrinolysis (GO:0042730)4.01157886
86serine family amino acid biosynthetic process (GO:0009070)4.00120257
87aldehyde catabolic process (GO:0046185)3.98589205
88uronic acid metabolic process (GO:0006063)3.96226288
89glucuronate metabolic process (GO:0019585)3.96226288
90plasma lipoprotein particle assembly (GO:0034377)3.93541649
91positive regulation of hemostasis (GO:1900048)3.88243248
92positive regulation of blood coagulation (GO:0030194)3.88243248
93cofactor catabolic process (GO:0051187)3.86633496
94blood coagulation, intrinsic pathway (GO:0007597)3.84021911
95epoxygenase P450 pathway (GO:0019373)3.83599972
96heme transport (GO:0015886)3.80010053
97flavonoid metabolic process (GO:0009812)3.78737945
98carboxylic acid catabolic process (GO:0046395)3.78227507
99organic acid catabolic process (GO:0016054)3.78227507
100exogenous drug catabolic process (GO:0042738)3.77331290
101negative regulation of lipase activity (GO:0060192)3.77071564
102phospholipid homeostasis (GO:0055091)3.74804730
103acute inflammatory response (GO:0002526)3.74703964
104positive regulation of lipid catabolic process (GO:0050996)3.74482978
105S-adenosylmethionine metabolic process (GO:0046500)3.74465169
106very-low-density lipoprotein particle assembly (GO:0034379)3.73741203
107ketone body metabolic process (GO:1902224)3.73519822
108acetyl-CoA metabolic process (GO:0006084)3.73156793
109complement activation, classical pathway (GO:0006958)3.72725714
110complement activation (GO:0006956)3.72272152
111short-chain fatty acid metabolic process (GO:0046459)3.70731172
112protein activation cascade (GO:0072376)3.69973662
113drug metabolic process (GO:0017144)3.68695928
114drug transmembrane transport (GO:0006855)3.66945226
115arginine catabolic process (GO:0006527)3.66702605
116* cholesterol homeostasis (GO:0042632)3.65219495
117* steroid catabolic process (GO:0006706)3.63632272
118positive regulation of triglyceride lipase activity (GO:0061365)3.61961559
119positive regulation of lipoprotein lipase activity (GO:0051006)3.61961559
120NAD biosynthetic process (GO:0009435)3.59386691
121* sterol homeostasis (GO:0055092)3.58968363
122positive regulation of coagulation (GO:0050820)3.58620739
123plasma lipoprotein particle organization (GO:0071827)3.57618038
124cytolysis (GO:0019835)3.56311697
125daunorubicin metabolic process (GO:0044597)3.52796371
126polyketide metabolic process (GO:0030638)3.52796371
127doxorubicin metabolic process (GO:0044598)3.52796371
128primary alcohol catabolic process (GO:0034310)3.52775662
129regulation of lipoprotein particle clearance (GO:0010984)3.52389984
130* xenobiotic metabolic process (GO:0006805)3.50951419
131negative regulation of humoral immune response (GO:0002921)3.48464809
132proline metabolic process (GO:0006560)3.45652601
133midgut development (GO:0007494)3.42878124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.43169252
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18034227
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.01025905
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.54903850
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.38857802
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.09401689
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.71435466
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06183283
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.99028927
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.12196595
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9422605
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91923007
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91341650
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.61599514
15HTT_18923047_ChIP-ChIP_STHdh_Human1.58536431
16CLOCK_20551151_ChIP-Seq_293T_Human1.55272677
17GATA1_22025678_ChIP-Seq_K562_Human1.46335665
18NFE2_27457419_Chip-Seq_LIVER_Mouse1.43928391
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39648603
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38361270
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25584830
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24905512
23SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19562003
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18302077
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.17434705
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17410105
27GBX2_23144817_ChIP-Seq_PC3_Human1.15580688
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13987989
29ER_23166858_ChIP-Seq_MCF-7_Human1.09657336
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.09333922
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08291365
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01636536
33CRX_20693478_ChIP-Seq_RETINA_Mouse1.00168485
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97984199
35CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97821028
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96438139
37RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94567353
38EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93593953
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92863073
40OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90201748
41IRF8_22096565_ChIP-ChIP_GC-B_Human0.89811242
42IGF1R_20145208_ChIP-Seq_DFB_Human0.89693611
43GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88245387
44* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88242303
45SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88227967
46HNFA_21074721_ChIP-Seq_CACO-2_Human0.87070156
47AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86916757
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85370833
49SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84725843
50ESRRB_18555785_Chip-Seq_ESCs_Mouse0.83383366
51SOX2_21211035_ChIP-Seq_LN229_Human0.83035044
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82755386
53OCT4_18555785_Chip-Seq_ESCs_Mouse0.82729120
54GATA6_21074721_ChIP-Seq_CACO-2_Human0.82479967
55EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.80853460
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80635298
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80284822
58GATA4_25053715_ChIP-Seq_YYC3_Human0.79496382
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79415789
60PHF8_20622853_ChIP-Seq_HELA_Human0.78903818
61STAT3_18555785_Chip-Seq_ESCs_Mouse0.78074096
62PU1_27457419_Chip-Seq_LIVER_Mouse0.77530846
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77437566
64KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77341906
65ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77200105
66RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75708564
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75532427
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75129743
69SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74505221
70ZNF263_19887448_ChIP-Seq_K562_Human0.74170577
71RAC3_21632823_ChIP-Seq_H3396_Human0.73717262
72KLF4_18555785_Chip-Seq_ESCs_Mouse0.73065553
73ZFX_18555785_Chip-Seq_ESCs_Mouse0.73003120
74RARA_24833708_ChIP-Seq_LIVER_Mouse0.72853329
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72350973
76NANOG_19829295_ChIP-Seq_ESCs_Human0.71851825
77SOX2_19829295_ChIP-Seq_ESCs_Human0.71851825
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71807808
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.71642907
80POU3F2_20337985_ChIP-ChIP_501MEL_Human0.70275345
81ERA_21632823_ChIP-Seq_H3396_Human0.70265903
82CBX2_22325352_ChIP-Seq_293T-Rex_Human0.69896715
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69708900
84P53_22387025_ChIP-Seq_ESCs_Mouse0.69124964
85SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68821896
86NFYA_21822215_ChIP-Seq_K562_Human0.68269870
87GATA3_21867929_ChIP-Seq_CD8_Mouse0.68069280
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.67520949
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66249505
90NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66249505
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.66230357
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.66230357
93P300_18555785_Chip-Seq_ESCs_Mouse0.66089796
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.65849685
95TP53_18474530_ChIP-ChIP_U2OS_Human0.65795070
96SOX2_18555785_Chip-Seq_ESCs_Mouse0.65494173
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65352212
98NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.65231835
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64610681
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.64314485
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.63921538
102CTCF_18555785_Chip-Seq_ESCs_Mouse0.63557315
103SOX2_20726797_ChIP-Seq_SW620_Human0.62886829
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.62525964
105NMYC_18555785_Chip-Seq_ESCs_Mouse0.62365086
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.62135065
107RARB_24833708_ChIP-Seq_LIVER_Mouse0.61273787
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60051431
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59274914
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58593401
111CEBPB_22108803_ChIP-Seq_LS180_Human0.57555674
112TAF15_26573619_Chip-Seq_HEK293_Human0.56050805
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56038794
114EGR1_19032775_ChIP-ChIP_M12_Human0.54329843
115AR_20517297_ChIP-Seq_VCAP_Human0.52387510
116* FOXA1_25552417_ChIP-Seq_VCAP_Human0.51629609
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51604147
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51459194
119CBP_21632823_ChIP-Seq_H3396_Human0.50832003
120STAT1_17558387_ChIP-Seq_HELA_Human0.50342821
121MYC_19915707_ChIP-ChIP_AK7_Human0.49040641
122ESET_19884257_ChIP-Seq_ESCs_Mouse0.48897020
123LXR_22292898_ChIP-Seq_THP-1_Human0.48616630
124P53_21459846_ChIP-Seq_SAOS-2_Human0.47442749
125* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47113963
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45784059
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.43919572
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.43660971
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.43554476
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.43491960
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42427517
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.42283256
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41798656
134GATA1_19941826_ChIP-Seq_K562_Human0.40893050
135PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.40232229
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.39825780
137BCAT_22108803_ChIP-Seq_LS180_Human0.39758592
138GATA2_19941826_ChIP-Seq_K562_Human0.39469620
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.39276549
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.39142137
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.38963018
142ERG_21242973_ChIP-ChIP_JURKAT_Human0.38755675
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38699582
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38201410
145TAF2_19829295_ChIP-Seq_ESCs_Human0.38105198
146GATA6_25053715_ChIP-Seq_YYC3_Human0.37730276
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.36071782
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.36017245
149CDX2_22108803_ChIP-Seq_LS180_Human0.35476790
150LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35147561
151IRF1_19129219_ChIP-ChIP_H3396_Human0.34549568
152STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.34093272
153NCOR_22424771_ChIP-Seq_293T_Human0.33732426
154ERG_20517297_ChIP-Seq_VCAP_Human0.33523418
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.33192377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.37999999
2MP0005360_urolithiasis7.67223017
3* MP0005085_abnormal_gallbladder_physiolo6.41140787
4* MP0005365_abnormal_bile_salt5.94791766
5MP0008875_abnormal_xenobiotic_pharmacok5.54871382
6MP0003806_abnormal_nucleotide_metabolis4.10709646
7MP0003252_abnormal_bile_duct4.03283384
8MP0010329_abnormal_lipoprotein_level3.57503468
9MP0005083_abnormal_biliary_tract3.26250000
10MP0009840_abnormal_foam_cell3.21070088
11MP0003195_calcinosis2.87153736
12MP0005332_abnormal_amino_acid2.82594077
13* MP0001666_abnormal_nutrient_absorption2.33990709
14MP0003191_abnormal_cellular_cholesterol2.17454462
15* MP0000609_abnormal_liver_physiology2.15780478
16* MP0002118_abnormal_lipid_homeostasis2.09193560
17MP0002138_abnormal_hepatobiliary_system2.01295306
18* MP0004019_abnormal_vitamin_homeostasis1.94490605
19MP0005319_abnormal_enzyme/_coenzyme1.85223460
20MP0001764_abnormal_homeostasis1.72238888
21MP0009697_abnormal_copulation1.62870859
22MP0005584_abnormal_enzyme/coenzyme_acti1.56776414
23* MP0003868_abnormal_feces_composition1.54467837
24MP0005451_abnormal_body_composition1.48843632
25MP0010386_abnormal_urinary_bladder1.38498893
26MP0003011_delayed_dark_adaptation1.32357688
27MP0003656_abnormal_erythrocyte_physiolo1.28483689
28MP0003186_abnormal_redox_activity1.27274072
29MP0009643_abnormal_urine_homeostasis1.23228557
30* MP0000598_abnormal_liver_morphology1.18199524
31MP0005647_abnormal_sex_gland1.12401878
32MP0003705_abnormal_hypodermis_morpholog1.10942865
33MP0009764_decreased_sensitivity_to1.09860095
34MP0009763_increased_sensitivity_to1.04588874
35MP0002254_reproductive_system_inflammat1.03386296
36MP0000604_amyloidosis1.02847191
37MP0005670_abnormal_white_adipose0.95560596
38MP0001915_intracranial_hemorrhage0.94969095
39MP0002132_abnormal_respiratory_system0.92026981
40MP0010368_abnormal_lymphatic_system0.91896074
41MP0005636_abnormal_mineral_homeostasis0.89638360
42MP0008469_abnormal_protein_level0.89239981
43MP0005408_hypopigmentation0.88121897
44MP0005084_abnormal_gallbladder_morpholo0.87951388
45MP0009642_abnormal_blood_homeostasis0.87550430
46MP0009765_abnormal_xenobiotic_induced0.82303287
47MP0005376_homeostasis/metabolism_phenot0.80319279
48MP0006036_abnormal_mitochondrial_physio0.79569504
49MP0002078_abnormal_glucose_homeostasis0.78392951
50MP0002876_abnormal_thyroid_physiology0.78053077
51MP0005220_abnormal_exocrine_pancreas0.77272913
52MP0005058_abnormal_lysosome_morphology0.74317169
53MP0004130_abnormal_muscle_cell0.73775072
54MP0002971_abnormal_brown_adipose0.73373856
55MP0001661_extended_life_span0.69791988
56MP0003690_abnormal_glial_cell0.69565792
57MP0005334_abnormal_fat_pad0.69282545
58MP0005535_abnormal_body_temperature0.68936139
59MP0009053_abnormal_anal_canal0.64922426
60MP0005266_abnormal_metabolism0.64750090
61MP0003329_amyloid_beta_deposits0.62675209
62MP0000639_abnormal_adrenal_gland0.60466098
63MP0001756_abnormal_urination0.58301000
64MP0003879_abnormal_hair_cell0.57221340
65MP0005448_abnormal_energy_balance0.55114795
66MP0002928_abnormal_bile_duct0.52990070
67MP0008874_decreased_physiological_sensi0.52669149
68MP0005464_abnormal_platelet_physiology0.52080503
69MP0006035_abnormal_mitochondrial_morpho0.52017248
70MP0002089_abnormal_postnatal_growth/wei0.51962360
71MP0002822_catalepsy0.50095740
72MP0003718_maternal_effect0.48702458
73MP0003638_abnormal_response/metabolism_0.48649862
74MP0008873_increased_physiological_sensi0.48495401
75MP0005395_other_phenotype0.46927356
76MP0008872_abnormal_physiological_respon0.45852356
77MP0003436_decreased_susceptibility_to0.45451832
78MP0003724_increased_susceptibility_to0.45436103
79MP0004782_abnormal_surfactant_physiolog0.45340055
80MP0002136_abnormal_kidney_physiology0.44518756
81MP0005248_abnormal_Harderian_gland0.42996357
82MP0000579_abnormal_nail_morphology0.42928100
83MP0002282_abnormal_trachea_morphology0.42902399
84MP0001440_abnormal_grooming_behavior0.42275846
85MP0003953_abnormal_hormone_level0.40557168
86MP0003075_altered_response_to0.40390578
87MP0002837_dystrophic_cardiac_calcinosis0.40084356
88MP0005666_abnormal_adipose_tissue0.40039049
89MP0004381_abnormal_hair_follicle0.39128607
90MP0009785_altered_susceptibility_to0.37926487
91MP0001986_abnormal_taste_sensitivity0.37785826
92MP0005166_decreased_susceptibility_to0.37107335
93MP0005410_abnormal_fertilization0.35112729
94MP0005646_abnormal_pituitary_gland0.34944196
95MP0002638_abnormal_pupillary_reflex0.34409651
96MP0009384_cardiac_valve_regurgitation0.33965947
97MP0003183_abnormal_peptide_metabolism0.33344128
98MP0000230_abnormal_systemic_arterial0.32880495
99MP0001853_heart_inflammation0.32576841
100MP0009115_abnormal_fat_cell0.32255555
101MP0000249_abnormal_blood_vessel0.31694942
102MP0001881_abnormal_mammary_gland0.30959209
103MP0005551_abnormal_eye_electrophysiolog0.30456822
104MP0002970_abnormal_white_adipose0.30395719
105MP0004883_abnormal_blood_vessel0.30053634
106MP0002168_other_aberrant_phenotype0.29162606
107MP0005197_abnormal_uvea_morphology0.28516850
108MP0001845_abnormal_inflammatory_respons0.28100778
109MP0002796_impaired_skin_barrier0.28090812
110MP0006082_CNS_inflammation0.25892746
111MP0003959_abnormal_lean_body0.24108509
112MP0005164_abnormal_response_to0.23175949
113MP0000427_abnormal_hair_cycle0.22693003
114MP0005167_abnormal_blood-brain_barrier0.22654594
115MP0001324_abnormal_eye_pigmentation0.21804228
116MP0005187_abnormal_penis_morphology0.21663502
117MP0002135_abnormal_kidney_morphology0.21006884
118MP0003453_abnormal_keratinocyte_physiol0.20772425
119MP0004043_abnormal_pH_regulation0.19385591
120MP0000920_abnormal_myelination0.17912760
121MP0003631_nervous_system_phenotype0.17771256
122MP0003632_abnormal_nervous_system0.16933548
123MP0003633_abnormal_nervous_system0.16454627
124MP0002249_abnormal_larynx_morphology0.16432154
125MP0001944_abnormal_pancreas_morphology0.15682533
126MP0005645_abnormal_hypothalamus_physiol0.15515829
127MP0009780_abnormal_chondrocyte_physiolo0.14246236

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.57092726
2Deep venous thrombosis (HP:0002625)7.46857607
3Intrahepatic cholestasis (HP:0001406)7.34667463
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.88803126
5Prolonged partial thromboplastin time (HP:0003645)6.65729962
6Hypobetalipoproteinemia (HP:0003563)6.49754610
7Xanthomatosis (HP:0000991)6.35480842
8Hyperlipoproteinemia (HP:0010980)5.61389898
9Complement deficiency (HP:0004431)5.30292569
10Joint hemorrhage (HP:0005261)4.84406036
11Hypolipoproteinemia (HP:0010981)4.82514477
12Epidermoid cyst (HP:0200040)4.79660063
13Hyperammonemia (HP:0001987)4.66843996
14Reduced antithrombin III activity (HP:0001976)4.48168718
15Abnormality of methionine metabolism (HP:0010901)4.47747028
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44074219
17Hyperglycinemia (HP:0002154)4.38901393
18Abnormality of the common coagulation pathway (HP:0010990)4.34527448
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.32727803
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.31327109
21Ketosis (HP:0001946)4.27163246
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.25762821
23Hypoalphalipoproteinemia (HP:0003233)4.19711932
24Fat malabsorption (HP:0002630)4.10305584
25Abnormality of pyrimidine metabolism (HP:0004353)4.07705630
26Hyperglycinuria (HP:0003108)3.92937872
27Abnormality of glycine metabolism (HP:0010895)3.92098914
28Abnormality of serine family amino acid metabolism (HP:0010894)3.92098914
29Abnormality of complement system (HP:0005339)3.86339964
30Hypercholesterolemia (HP:0003124)3.77887606
31Conjugated hyperbilirubinemia (HP:0002908)3.76567452
32Hypoglycemic coma (HP:0001325)3.76333364
33Abnormality of the intrinsic pathway (HP:0010989)3.75841739
34Osteomalacia (HP:0002749)3.60786138
35Hyperbilirubinemia (HP:0002904)3.38535063
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35130435
37Abnormality of fatty-acid metabolism (HP:0004359)3.25552013
38Delayed CNS myelination (HP:0002188)3.13998616
39Abnormality of serum amino acid levels (HP:0003112)3.13330019
40Abnormality of nucleobase metabolism (HP:0010932)3.12497093
41Steatorrhea (HP:0002570)3.07516643
42Myocardial infarction (HP:0001658)2.98901372
43Hepatocellular carcinoma (HP:0001402)2.97813025
44Ketoacidosis (HP:0001993)2.96237841
45Skin nodule (HP:0200036)2.93454898
46Abnormality of the Achilles tendon (HP:0005109)2.87990256
47Hypochromic microcytic anemia (HP:0004840)2.87760104
48Spontaneous abortion (HP:0005268)2.76915028
49Metabolic acidosis (HP:0001942)2.72748477
50Systemic lupus erythematosus (HP:0002725)2.67668178
51Pulmonary embolism (HP:0002204)2.65871034
52Acanthocytosis (HP:0001927)2.65117570
53Abnormality of purine metabolism (HP:0004352)2.64892825
54Arthropathy (HP:0003040)2.62985681
55Lethargy (HP:0001254)2.62732890
56Vascular calcification (HP:0004934)2.58885366
57Purpura (HP:0000979)2.54472751
58Hyperphosphaturia (HP:0003109)2.53178909
59Cerebral edema (HP:0002181)2.51434703
60Spastic diplegia (HP:0001264)2.51245240
61Glomerulonephritis (HP:0000099)2.51157554
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50911585
63Dicarboxylic aciduria (HP:0003215)2.50911585
64Glycosuria (HP:0003076)2.48483063
65Abnormality of urine glucose concentration (HP:0011016)2.48483063
66Abnormal gallbladder morphology (HP:0012437)2.47538519
67Mitral stenosis (HP:0001718)2.46533351
68Hypoglycemic seizures (HP:0002173)2.43695464
69Irritability (HP:0000737)2.41019790
70Fair hair (HP:0002286)2.40094747
71Gout (HP:0001997)2.39719194
72Cholelithiasis (HP:0001081)2.39050901
73Neonatal onset (HP:0003623)2.37638384
74Recurrent gram-negative bacterial infections (HP:0005420)2.31178482
75Cardiovascular calcification (HP:0011915)2.29526915
76Cholecystitis (HP:0001082)2.27824543
77Abnormal gallbladder physiology (HP:0012438)2.27824543
78Bile duct proliferation (HP:0001408)2.26523568
79Abnormal biliary tract physiology (HP:0012439)2.26523568
80Menorrhagia (HP:0000132)2.20295443
81Esophageal varix (HP:0002040)2.18334426
82Lower limb hyperreflexia (HP:0002395)2.16856979
83Brushfield spots (HP:0001088)2.16516913
84Increased serum ferritin (HP:0003281)2.16125215
85Abnormal pupillary function (HP:0007686)2.14037130
86Amyloidosis (HP:0011034)2.12775482
87Gingival bleeding (HP:0000225)2.10050939
88Enlarged kidneys (HP:0000105)2.09474229
89Pancreatitis (HP:0001733)2.09312562
90Gangrene (HP:0100758)2.07792928
91Poikilocytosis (HP:0004447)2.07086600
92Malnutrition (HP:0004395)2.06869269
93Late onset (HP:0003584)2.04693318
94Sensorimotor neuropathy (HP:0007141)2.03411298
95Vomiting (HP:0002013)2.03392240
96Elevated alkaline phosphatase (HP:0003155)2.01600310
97Abnormal urine phosphate concentration (HP:0012599)2.00822699
98Achilles tendon contracture (HP:0001771)1.99781016
99Opisthotonus (HP:0002179)1.99600169
100Thrombophlebitis (HP:0004418)1.99182051
101Abnormality of the gallbladder (HP:0005264)1.99014140
102Hyperinsulinemic hypoglycemia (HP:0000825)1.96607865
103Generalized aminoaciduria (HP:0002909)1.96524659
104Hemorrhage of the eye (HP:0011885)1.96396638
105Alkalosis (HP:0001948)1.94297012
106Proximal tubulopathy (HP:0000114)1.90233173
107Abnormality of proline metabolism (HP:0010907)1.90172653
108Hydroxyprolinuria (HP:0003080)1.90172653
109Rickets (HP:0002748)1.90123241
110Abnormality of alkaline phosphatase activity (HP:0004379)1.88926072
111Retinal atrophy (HP:0001105)1.87415578
112Abnormal cartilage morphology (HP:0002763)1.87232368
113Hypophosphatemic rickets (HP:0004912)1.85766145
114Abnormality of iron homeostasis (HP:0011031)1.84872942
115Status epilepticus (HP:0002133)1.84512750
116Renal cortical cysts (HP:0000803)1.83911780
117Hyperglycemia (HP:0003074)1.82939647
118Abnormality of transition element cation homeostasis (HP:0011030)1.82233542
119Decreased subcutaneous fat (HP:0001002)1.80812511
120Abnormal enzyme/coenzyme activity (HP:0012379)1.80626286
121Elevated hepatic transaminases (HP:0002910)1.79140830
122Nephritis (HP:0000123)1.77988314
123Abnormality of vitamin metabolism (HP:0100508)1.75722468
124Atrioventricular block (HP:0001678)1.73741811
125Beaking of vertebral bodies (HP:0004568)1.65529166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.01643837
2SIK14.78084816
3FGFR44.43266154
4ERN13.81503054
5INSRR3.26618631
6ERBB43.15271696
7TAOK33.06396533
8BMPR1B2.55782202
9PKN22.49416337
10MAP2K42.44648464
11WNK32.19981554
12MST1R2.13141463
13FLT32.03526334
14MAPK111.96841199
15MUSK1.84808785
16STK161.76788033
17MARK11.72600616
18LATS11.71626437
19NTRK31.70511693
20PDK21.70224669
21PIK3CG1.69597847
22ACVR1B1.65526248
23TYK21.65139073
24EIF2AK31.63370325
25TRIB31.60730644
26FGFR21.50619236
27ABL21.50024809
28PRKG11.49957816
29FRK1.48326798
30DAPK21.46094757
31PTK61.39763873
32NEK91.38663102
33JAK21.27562208
34KDR1.25750869
35ADRBK21.24009935
36MAP3K71.23333770
37CAMKK21.23032280
38PRKACA1.22968919
39PRKAA21.19187814
40TXK1.18715322
41CSNK1D1.16834484
42PINK11.13646168
43MAP3K141.13104187
44CDK81.12082941
45SGK11.11513814
46PRKCE1.11095842
47ERBB21.09925515
48GRK61.09553359
49MAP2K31.06309741
50MAPK41.05693430
51MAPK131.04804377
52TBK11.04438435
53WNK41.04228482
54JAK11.03588423
55PRKCB1.01445563
56TNK21.00498936
57CLK10.97898592
58PRKCZ0.96354617
59MAP3K100.94144576
60CASK0.90598952
61PIM20.88273144
62MAP3K30.87741882
63MAPK120.85732382
64DYRK20.85415518
65STK38L0.85127830
66MET0.83715886
67CDK60.80045687
68MYLK0.79979113
69PRKACG0.76578189
70MAPK150.74910753
71MAP2K60.74665776
72KIT0.74457391
73CAMK2G0.73755072
74CSK0.73525533
75TIE10.72535826
76RPS6KA30.72147736
77PRPF4B0.71560360
78EPHB10.70947665
79GRK70.70051915
80MAP2K20.69161005
81DYRK1B0.69062158
82MAP3K110.68921773
83SGK30.68838683
84CSNK1A10.68782542
85CAMK1D0.67554262
86ZAP700.67102938
87EPHA30.67096060
88GSK3A0.66806282
89PRKACB0.66145155
90PRKAA10.65630378
91IRAK30.64557826
92MAPK70.63552910
93CSNK2A20.63340310
94CSF1R0.62595296
95EPHA40.60895351
96TGFBR20.60528787
97MAP4K20.60269516
98FGFR30.60177316
99MAP3K120.58786692
100IKBKE0.58263115
101CAMK1G0.57877666
102RIPK10.57483157
103OXSR10.55468724
104PRKCQ0.54420492
105TAOK20.54153103
106MAP3K130.53659472
107SGK20.53419807
108ZAK0.52826270
109BCR0.51399764
110TGFBR10.50955383
111CSNK1G10.50456809
112PKN10.50212452
113LMTK20.50021180
114RET0.49428037
115CSNK2A10.49116166
116SRC0.48762515
117EIF2AK20.48011450
118MAPK100.48009780
119PTK20.47994882
120IGF1R0.47580033
121DYRK1A0.47360321
122MAP3K50.47321900
123PRKCI0.46118275
124PDPK10.45726196
125GRK10.45416229
126NLK0.44426534
127CAMKK10.44082213
128STK380.42152589
129MAP3K60.41984986
130CDK40.40785153
131MAPKAPK30.40668451
132PBK0.40383115
133PRKCG0.39984564
134MAP2K10.36655815
135SGK2230.35607070
136SGK4940.35607070
137PIK3CA0.35329817
138EGFR0.34214411
139MTOR0.32620417
140CSNK1G20.31883540
141PDK10.30206981
142IRAK20.30108158
143CAMK40.29784241
144ICK0.29615858
145PRKCA0.28122565
146AKT30.26945547
147CSNK1G30.24700475
148LATS20.23971078
149ABL10.23677041
150IRAK10.23331814
151MAP3K20.20356708
152ITK0.18713364
153MAPK30.18252969
154PDK30.17948943

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.38893819
2Nitrogen metabolism_Homo sapiens_hsa009103.77950395
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.53852646
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45047502
5Arginine biosynthesis_Homo sapiens_hsa002203.17731788
6Complement and coagulation cascades_Homo sapiens_hsa046102.71642112
7Tryptophan metabolism_Homo sapiens_hsa003802.70568011
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66145528
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54172103
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54052046
11Fatty acid degradation_Homo sapiens_hsa000712.42872192
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32788815
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32759629
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.21933249
15Butanoate metabolism_Homo sapiens_hsa006502.09161663
16Peroxisome_Homo sapiens_hsa041462.04538505
17Chemical carcinogenesis_Homo sapiens_hsa052042.01376753
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.99800262
19Caffeine metabolism_Homo sapiens_hsa002321.98141958
20* Steroid hormone biosynthesis_Homo sapiens_hsa001401.90753851
21Histidine metabolism_Homo sapiens_hsa003401.89436898
22Propanoate metabolism_Homo sapiens_hsa006401.88087072
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.82527438
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79336233
25Staphylococcus aureus infection_Homo sapiens_hsa051501.75864857
26* PPAR signaling pathway_Homo sapiens_hsa033201.75075143
27Retinol metabolism_Homo sapiens_hsa008301.74737454
28Fatty acid metabolism_Homo sapiens_hsa012121.73159366
29beta-Alanine metabolism_Homo sapiens_hsa004101.70524929
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68005047
31Phenylalanine metabolism_Homo sapiens_hsa003601.61660927
32Selenocompound metabolism_Homo sapiens_hsa004501.60363666
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52871046
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51166148
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48040769
36Tyrosine metabolism_Homo sapiens_hsa003501.43314339
37* Bile secretion_Homo sapiens_hsa049761.41328176
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.33334028
39Pyruvate metabolism_Homo sapiens_hsa006201.32082761
40Starch and sucrose metabolism_Homo sapiens_hsa005001.31472326
41Sulfur metabolism_Homo sapiens_hsa009201.30766953
42Fatty acid elongation_Homo sapiens_hsa000621.25416470
43Biosynthesis of amino acids_Homo sapiens_hsa012301.22824291
44Steroid biosynthesis_Homo sapiens_hsa001001.21801888
45ABC transporters_Homo sapiens_hsa020101.20852074
46Folate biosynthesis_Homo sapiens_hsa007901.16763062
47Fat digestion and absorption_Homo sapiens_hsa049751.10578761
48Carbon metabolism_Homo sapiens_hsa012001.09288567
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04713467
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.01415320
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00236672
52Arginine and proline metabolism_Homo sapiens_hsa003300.96904355
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.94610843
54Vitamin B6 metabolism_Homo sapiens_hsa007500.88450646
55Sulfur relay system_Homo sapiens_hsa041220.87879473
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86969368
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83895252
58Vitamin digestion and absorption_Homo sapiens_hsa049770.82696540
59Lysine degradation_Homo sapiens_hsa003100.81554851
60One carbon pool by folate_Homo sapiens_hsa006700.75866893
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67996192
62Glycerolipid metabolism_Homo sapiens_hsa005610.65974209
63Glutathione metabolism_Homo sapiens_hsa004800.62054148
64Pentose phosphate pathway_Homo sapiens_hsa000300.53780367
65Fatty acid biosynthesis_Homo sapiens_hsa000610.51570881
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45648364
67* Metabolic pathways_Homo sapiens_hsa011000.44647028
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35858878
69Prion diseases_Homo sapiens_hsa050200.31740730
70Linoleic acid metabolism_Homo sapiens_hsa005910.24655688
71Insulin resistance_Homo sapiens_hsa049310.23353833
72Galactose metabolism_Homo sapiens_hsa000520.22196059
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21783095
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.21453217
75Fructose and mannose metabolism_Homo sapiens_hsa000510.21436915
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17320072
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.14409599
78Glucagon signaling pathway_Homo sapiens_hsa049220.10952459
79Other glycan degradation_Homo sapiens_hsa005110.07080471
80AMPK signaling pathway_Homo sapiens_hsa041520.02398041
81Serotonergic synapse_Homo sapiens_hsa047260.02013969
82Pertussis_Homo sapiens_hsa05133-0.2508857
83Amoebiasis_Homo sapiens_hsa05146-0.2463866
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2453445
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2328271
86Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2253696
87Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2175656
88Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2074604
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1962015
90Renin-angiotensin system_Homo sapiens_hsa04614-0.1941019
91Cocaine addiction_Homo sapiens_hsa05030-0.1880747
92Hepatitis C_Homo sapiens_hsa05160-0.1868836
93Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1714881
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1654801
95African trypanosomiasis_Homo sapiens_hsa05143-0.1548377
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1479409
97Regulation of autophagy_Homo sapiens_hsa04140-0.1440323
98Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1426272
99Type II diabetes mellitus_Homo sapiens_hsa04930-0.1386081
100Ether lipid metabolism_Homo sapiens_hsa00565-0.1319934
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0988879
102Insulin signaling pathway_Homo sapiens_hsa04910-0.0978873
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0975854
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0933932
105N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0831080
106Mineral absorption_Homo sapiens_hsa04978-0.0720293
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0550480
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0393348
109Sphingolipid metabolism_Homo sapiens_hsa00600-0.0317193

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