CYP7B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.50860999
2L-phenylalanine catabolic process (GO:0006559)7.50860999
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.17505404
4L-phenylalanine metabolic process (GO:0006558)7.17505404
5aromatic amino acid family catabolic process (GO:0009074)7.01107127
6indole-containing compound catabolic process (GO:0042436)6.60671389
7indolalkylamine catabolic process (GO:0046218)6.60671389
8tryptophan catabolic process (GO:0006569)6.60671389
9kynurenine metabolic process (GO:0070189)6.32693440
10glyoxylate metabolic process (GO:0046487)6.16455526
11tryptophan metabolic process (GO:0006568)6.15621482
12* bile acid biosynthetic process (GO:0006699)6.08859717
13complement activation, alternative pathway (GO:0006957)6.01977779
14regulation of protein activation cascade (GO:2000257)5.94279254
15regulation of complement activation (GO:0030449)5.66976127
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.65159055
17urea metabolic process (GO:0019627)5.59835715
18urea cycle (GO:0000050)5.59835715
19cysteine metabolic process (GO:0006534)5.59751259
20negative regulation of fibrinolysis (GO:0051918)5.38300792
21alpha-linolenic acid metabolic process (GO:0036109)5.37737525
22sulfur amino acid catabolic process (GO:0000098)5.36745186
23protein carboxylation (GO:0018214)5.31294859
24peptidyl-glutamic acid carboxylation (GO:0017187)5.31294859
25regulation of fibrinolysis (GO:0051917)5.29871307
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.24500788
27serine family amino acid catabolic process (GO:0009071)5.19836594
28nitrogen cycle metabolic process (GO:0071941)5.15243981
29aromatic amino acid family metabolic process (GO:0009072)5.06757918
30high-density lipoprotein particle remodeling (GO:0034375)5.00951492
31* bile acid metabolic process (GO:0008206)5.00154070
32homocysteine metabolic process (GO:0050667)4.96646031
33lysine metabolic process (GO:0006553)4.93907103
34lysine catabolic process (GO:0006554)4.93907103
35regulation of T-helper 1 cell differentiation (GO:0045625)4.87766504
36coenzyme catabolic process (GO:0009109)4.81023516
37alpha-amino acid catabolic process (GO:1901606)4.71345198
38cytolysis (GO:0019835)4.67235445
39indolalkylamine metabolic process (GO:0006586)4.64506284
40amino-acid betaine metabolic process (GO:0006577)4.61247681
41regulation of triglyceride catabolic process (GO:0010896)4.60009606
42tyrosine metabolic process (GO:0006570)4.59969934
43amine catabolic process (GO:0009310)4.56613926
44cellular biogenic amine catabolic process (GO:0042402)4.56613926
45glycine metabolic process (GO:0006544)4.48691845
46regulation of vitamin D biosynthetic process (GO:0060556)4.46774389
47reverse cholesterol transport (GO:0043691)4.44685953
48triglyceride homeostasis (GO:0070328)4.39015555
49acylglycerol homeostasis (GO:0055090)4.39015555
50protein-lipid complex remodeling (GO:0034368)4.37812845
51macromolecular complex remodeling (GO:0034367)4.37812845
52plasma lipoprotein particle remodeling (GO:0034369)4.37812845
53serine family amino acid metabolic process (GO:0009069)4.37778452
54cellular amino acid catabolic process (GO:0009063)4.36949264
55cellular glucuronidation (GO:0052695)4.36193584
56bile acid and bile salt transport (GO:0015721)4.33427049
57glutamate metabolic process (GO:0006536)4.32610756
58cellular ketone body metabolic process (GO:0046950)4.30660722
59ethanol oxidation (GO:0006069)4.28179913
60cellular modified amino acid catabolic process (GO:0042219)4.27106304
61cellular response to type I interferon (GO:0071357)4.26310147
62type I interferon signaling pathway (GO:0060337)4.26310147
63complement activation, classical pathway (GO:0006958)4.23684282
64imidazole-containing compound metabolic process (GO:0052803)4.22709478
65regulation of cholesterol esterification (GO:0010872)4.20784934
66dicarboxylic acid biosynthetic process (GO:0043650)4.18962428
67response to type I interferon (GO:0034340)4.17797646
68benzene-containing compound metabolic process (GO:0042537)4.14027960
69regulation of interferon-alpha production (GO:0032647)4.11909348
70serine family amino acid biosynthetic process (GO:0009070)4.11888102
71regulation of chronic inflammatory response (GO:0002676)4.10797998
72complement activation (GO:0006956)4.08059391
73regulation of cytokine secretion involved in immune response (GO:0002739)4.06290072
74negative regulation of sterol transport (GO:0032372)4.04091750
75negative regulation of cholesterol transport (GO:0032375)4.04091750
76phospholipid efflux (GO:0033700)3.98371489
77arginine metabolic process (GO:0006525)3.93671335
78aldehyde catabolic process (GO:0046185)3.93450621
79acetyl-CoA metabolic process (GO:0006084)3.93119848
80fibrinolysis (GO:0042730)3.92525761
81protein activation cascade (GO:0072376)3.91655045
82plasma lipoprotein particle clearance (GO:0034381)3.90661335
83urate metabolic process (GO:0046415)3.90219948
84positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.90068244
85glucuronate metabolic process (GO:0019585)3.89407196
86uronic acid metabolic process (GO:0006063)3.89407196
87cofactor catabolic process (GO:0051187)3.84111858
88regulation of immunoglobulin secretion (GO:0051023)3.80950304
89regulation of fever generation (GO:0031620)3.80316222
90regulation of bile acid biosynthetic process (GO:0070857)3.80195031
91cholesterol efflux (GO:0033344)3.79512305
92adhesion of symbiont to host cell (GO:0044650)3.78572245
93virion attachment to host cell (GO:0019062)3.78572245
94regulation of vitamin metabolic process (GO:0030656)3.77823523
95carboxylic acid catabolic process (GO:0046395)3.77648453
96organic acid catabolic process (GO:0016054)3.77648453
97drug transmembrane transport (GO:0006855)3.77168891
98low-density lipoprotein particle remodeling (GO:0034374)3.76597206
99blood coagulation, intrinsic pathway (GO:0007597)3.73459633
100ketone body metabolic process (GO:1902224)3.72147178
101short-chain fatty acid metabolic process (GO:0046459)3.70071962
102regulation of cholesterol homeostasis (GO:2000188)3.69366843
103branching involved in labyrinthine layer morphogenesis (GO:0060670)3.69022708
104aspartate family amino acid catabolic process (GO:0009068)3.65444345
105drug catabolic process (GO:0042737)3.62198778
106NAD biosynthetic process (GO:0009435)3.57915707
107pyridine nucleotide biosynthetic process (GO:0019363)3.55185256
108nicotinamide nucleotide biosynthetic process (GO:0019359)3.55185256
109cholesterol homeostasis (GO:0042632)3.54690468
110plasma lipoprotein particle assembly (GO:0034377)3.54612968
111phospholipid homeostasis (GO:0055091)3.54249109
112negative regulation of protein activation cascade (GO:2000258)3.53796015
113exogenous drug catabolic process (GO:0042738)3.53510442
114heme transport (GO:0015886)3.51425527
115sterol homeostasis (GO:0055092)3.49547165
116adhesion of symbiont to host (GO:0044406)3.48037236
117positive regulation of chemokine biosynthetic process (GO:0045080)3.46317785
118NIK/NF-kappaB signaling (GO:0038061)3.43955476
119opsonization (GO:0008228)3.43944204
120CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.36112311
121positive regulation of interferon-alpha production (GO:0032727)3.35957720
122negative regulation of nitric oxide biosynthetic process (GO:0045019)3.33302495
123response to protozoan (GO:0001562)3.32849236
124regulation of membrane protein ectodomain proteolysis (GO:0051043)3.31905824
125positive regulation of heat generation (GO:0031652)3.30841676
126T-helper 1 type immune response (GO:0042088)3.27579690
127germinal center formation (GO:0002467)3.26030945
128negative regulation of interleukin-12 production (GO:0032695)3.23858532
129myeloid dendritic cell differentiation (GO:0043011)3.21868315
130regulation of heterotypic cell-cell adhesion (GO:0034114)3.20562457
131regulation of chemokine biosynthetic process (GO:0045073)3.19318024
132regulation of nitric oxide biosynthetic process (GO:0045428)3.14916201
133interferon-gamma-mediated signaling pathway (GO:0060333)3.14748059
134positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.12015016
135defense response to protozoan (GO:0042832)3.09850634
136positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.08844015
137omega-hydroxylase P450 pathway (GO:0097267)3.02110369
138positive regulation of nitric oxide biosynthetic process (GO:0045429)3.01296002
139mature B cell differentiation involved in immune response (GO:0002313)3.01049836
140regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99922596
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97525088
142regulation of mononuclear cell migration (GO:0071675)2.96658082
143macrophage activation involved in immune response (GO:0002281)2.93787208
144positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.93609011
145regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91524899
146positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.90747908
147response to peptidoglycan (GO:0032494)2.87462533
148fat-soluble vitamin biosynthetic process (GO:0042362)2.86217935
149positive regulation of type 2 immune response (GO:0002830)2.86176406
150regulation of T-helper cell differentiation (GO:0045622)2.81882150
151immunoglobulin mediated immune response (GO:0016064)2.81271523
152regulation of heat generation (GO:0031650)2.79313871
153activation of MAPKKK activity (GO:0000185)2.78733047
154negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.77834668
155regulation of interferon-gamma biosynthetic process (GO:0045072)2.76577247
156T cell lineage commitment (GO:0002360)2.76247017
157cellular response to interferon-alpha (GO:0035457)2.74383677
158interleukin-6-mediated signaling pathway (GO:0070102)2.71045425
159negative regulation of viral genome replication (GO:0045071)2.69779799
160regulation of macrophage chemotaxis (GO:0010758)2.69109340
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.66211314
162bone resorption (GO:0045453)2.64756850
163positive regulation of natural killer cell differentiation (GO:0032825)2.63852948
164myeloid dendritic cell activation (GO:0001773)2.63613495
165dendritic cell differentiation (GO:0097028)2.62768728
166polyketide metabolic process (GO:0030638)2.61125453
167doxorubicin metabolic process (GO:0044598)2.61125453
168daunorubicin metabolic process (GO:0044597)2.61125453
169negative regulation of myeloid cell apoptotic process (GO:0033033)2.60435376
170positive regulation of T-helper cell differentiation (GO:0045624)2.59772876
171cellular response to exogenous dsRNA (GO:0071360)2.58653351
172cellular response to lipopolysaccharide (GO:0071222)2.54512188
173epoxygenase P450 pathway (GO:0019373)2.54179685
174regulation of interleukin-12 production (GO:0032655)2.53976852
175positive regulation of humoral immune response (GO:0002922)2.53764761
176positive regulation of interferon-beta production (GO:0032728)2.53601479
177regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.52856767
178cellular response to thyroid hormone stimulus (GO:0097067)2.51256444
179regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.49165728
180acute-phase response (GO:0006953)2.48102312
181positive regulation of interleukin-12 production (GO:0032735)2.46624894
182cellular response to interferon-gamma (GO:0071346)2.46427427
183positive regulation of acute inflammatory response (GO:0002675)2.46368034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.20515923
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.13067706
3PPARA_22158963_ChIP-Seq_LIVER_Mouse7.04652860
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.35492567
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21668810
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.77108622
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.51356054
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03430379
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83718850
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.47358709
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.02028712
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70890740
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.69137842
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67315243
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.66292675
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.58580677
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38269423
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19333341
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03419464
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01662780
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8463340
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97675451
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93204140
24* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93118224
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92026569
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88775637
27VDR_24787735_ChIP-Seq_THP-1_Human1.76476364
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.73831772
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71719662
30HTT_18923047_ChIP-ChIP_STHdh_Human1.62826658
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.61577685
32SCL_19346495_ChIP-Seq_HPC-7_Human1.53812906
33NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53066423
34CLOCK_20551151_ChIP-Seq_293T_Human1.49767371
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46357131
36GATA1_22025678_ChIP-Seq_K562_Human1.41623498
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.40787597
38HNF4A_19822575_ChIP-Seq_HepG2_Human1.39643427
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39207369
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38906581
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36405147
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26194941
43TP53_16413492_ChIP-PET_HCT116_Human1.22658591
44TP53_18474530_ChIP-ChIP_U2OS_Human1.21347833
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.19953024
46RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19928505
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19411460
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17067899
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12579320
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.09999074
51EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09911875
52* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08910635
53* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07707338
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07535645
55PU1_27457419_Chip-Seq_LIVER_Mouse1.05734443
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05321480
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04953403
58GATA1_19941826_ChIP-Seq_K562_Human1.04907865
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.04884492
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02069183
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00633267
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00320916
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00111673
64* CJUN_26792858_Chip-Seq_BT549_Human0.99845809
65* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99258805
66RUNX_20019798_ChIP-Seq_JUKART_Human0.96585545
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96198952
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96137812
69SOX2_18555785_Chip-Seq_ESCs_Mouse0.95524177
70* E2F1_18555785_Chip-Seq_ESCs_Mouse0.95508099
71ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95382520
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94083680
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94034197
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93712821
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92729608
76BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92188764
77KLF4_18555785_Chip-Seq_ESCs_Mouse0.90907944
78ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90893284
79* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.90819067
80CMYC_18555785_Chip-Seq_ESCs_Mouse0.90561845
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.89953817
82* NMYC_18555785_Chip-Seq_ESCs_Mouse0.89835916
83VDR_24763502_ChIP-Seq_THP-1_Human0.89390395
84IGF1R_20145208_ChIP-Seq_DFB_Human0.89168497
85SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88467083
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88294341
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87690558
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86621806
89SOX2_20726797_ChIP-Seq_SW620_Human0.86470804
90STAT3_18555785_Chip-Seq_ESCs_Mouse0.85498523
91EP300_21415370_ChIP-Seq_HL-1_Mouse0.85474906
92TAL1_26923725_Chip-Seq_HPCs_Mouse0.84243840
93OCT4_18555785_Chip-Seq_ESCs_Mouse0.84077904
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83066713
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.82463173
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82373307
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82128560
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81582976
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81547694
100TP63_23658742_ChIP-Seq_EP156T_Human0.80787215
101ZFX_18555785_Chip-Seq_ESCs_Mouse0.80768952
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79926858
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79926858
104* P53_22387025_ChIP-Seq_ESCs_Mouse0.79848805
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.79430708
106PU_27001747_Chip-Seq_BMDM_Mouse0.79216030
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78878257
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78505917
109GBX2_23144817_ChIP-Seq_PC3_Human0.78397666
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77737369
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74419219
112GATA4_25053715_ChIP-Seq_YYC3_Human0.73284847
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71571797
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70655755
115GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.70602023
116TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.70028231
117RARA_24833708_ChIP-Seq_LIVER_Mouse0.69508234
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69167280
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68294323
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68246594
121RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65582741
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.63211249
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.63177279
124RARB_24833708_ChIP-Seq_LIVER_Mouse0.60262647
125AR_20517297_ChIP-Seq_VCAP_Human0.59008058
126TAF15_26573619_Chip-Seq_HEK293_Human0.57693608
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57134961
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56426283
129BCAT_22108803_ChIP-Seq_LS180_Human0.56381980
130EGR1_19032775_ChIP-ChIP_M12_Human0.54497223
131CBP_21632823_ChIP-Seq_H3396_Human0.54187124
132CEBPB_22108803_ChIP-Seq_LS180_Human0.53996910
133* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.53849994
134* MYC_19915707_ChIP-ChIP_AK7_Human0.53382153
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.53364095
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52673168
137ZNF263_19887448_ChIP-Seq_K562_Human0.50643812
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.50113260
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.49905265
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.49711251
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49517273
142ESET_19884257_ChIP-Seq_ESCs_Mouse0.49473336
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.49099031
144ERG_21242973_ChIP-ChIP_JURKAT_Human0.48981102
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.48755044
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.48536260
147LXR_22292898_ChIP-Seq_THP-1_Human0.46975659
148STAT1_17558387_ChIP-Seq_HELA_Human0.46698720
149* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.46556807
150FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45703890
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.45417765
152* TAF2_19829295_ChIP-Seq_ESCs_Human0.43690003
153PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43352238
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.42288904
155P53_21459846_ChIP-Seq_SAOS-2_Human0.42037540
156STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41288301
157MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.41276602
158MYC_27129775_Chip-Seq_CORNEA_Mouse0.41136599
159ESR1_20079471_ChIP-ChIP_T-47D_Human0.41047360
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40869263
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.39615932
162FOXH1_21741376_ChIP-Seq_EPCs_Human0.38847134
163FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.38170072
164* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.37896354
165ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.37789838
166CDX2_22108803_ChIP-Seq_LS180_Human0.37254457
167NCOR_22424771_ChIP-Seq_293T_Human0.36240023
168FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.36124864
169EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.35885109
170PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.35817609
171OCT4_21477851_ChIP-Seq_ESCs_Mouse0.35295173
172PPAR_26484153_Chip-Seq_NCI-H1993_Human0.35142955
173CRX_20693478_ChIP-Seq_RETINA_Mouse0.34743844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.29074563
2MP0005360_urolithiasis7.77056631
3MP0005085_abnormal_gallbladder_physiolo6.50491920
4MP0005365_abnormal_bile_salt6.17008881
5MP0003303_peritoneal_inflammation4.92672739
6MP0008875_abnormal_xenobiotic_pharmacok4.73340851
7MP0003806_abnormal_nucleotide_metabolis4.40747602
8MP0003252_abnormal_bile_duct4.09428902
9MP0010329_abnormal_lipoprotein_level3.45100388
10MP0003300_gastrointestinal_ulcer3.08279404
11MP0005332_abnormal_amino_acid2.92046333
12MP0009840_abnormal_foam_cell2.90766571
13MP0002148_abnormal_hypersensitivity_rea2.89843697
14MP0005083_abnormal_biliary_tract2.86065760
15MP0003195_calcinosis2.82409872
16MP0001666_abnormal_nutrient_absorption2.61042339
17MP0009785_altered_susceptibility_to2.56457199
18MP0004510_myositis2.54495521
19MP0001835_abnormal_antigen_presentation2.50670116
20MP0001790_abnormal_immune_system2.39127580
21MP0005387_immune_system_phenotype2.39127580
22MP0002138_abnormal_hepatobiliary_system2.20991739
23MP0003436_decreased_susceptibility_to2.20250254
24MP0006054_spinal_hemorrhage2.17501385
25MP0003191_abnormal_cellular_cholesterol2.16692874
26MP0004019_abnormal_vitamin_homeostasis2.16006224
27MP0008438_abnormal_cutaneous_collagen2.15448061
28MP0005397_hematopoietic_system_phenotyp2.10253699
29MP0001545_abnormal_hematopoietic_system2.10253699
30MP0000609_abnormal_liver_physiology2.07625928
31* MP0002118_abnormal_lipid_homeostasis2.01221137
32MP0003868_abnormal_feces_composition2.01140177
33MP0008004_abnormal_stomach_pH1.99792008
34MP0005275_abnormal_skin_tensile1.98270071
35MP0005000_abnormal_immune_tolerance1.95590592
36MP0005025_abnormal_response_to1.88576603
37MP0005319_abnormal_enzyme/_coenzyme1.84675433
38MP0002419_abnormal_innate_immunity1.81248056
39MP0002332_abnormal_exercise_endurance1.81226328
40MP0004947_skin_inflammation1.79312320
41MP0003453_abnormal_keratinocyte_physiol1.74445096
42MP0001800_abnormal_humoral_immune1.67351862
43MP0001764_abnormal_homeostasis1.67273102
44MP0005671_abnormal_response_to1.67075000
45MP0001542_abnormal_bone_strength1.66964514
46MP0000685_abnormal_immune_system1.64892232
47MP0000465_gastrointestinal_hemorrhage1.63985764
48MP0005023_abnormal_wound_healing1.61210984
49MP0005584_abnormal_enzyme/coenzyme_acti1.57705575
50MP0001533_abnormal_skeleton_physiology1.56483465
51MP0002452_abnormal_antigen_presenting1.55102003
52MP0009697_abnormal_copulation1.53642772
53MP0002723_abnormal_immune_serum1.50111571
54MP0003183_abnormal_peptide_metabolism1.45932790
55MP0000343_altered_response_to1.44161163
56MP0003011_delayed_dark_adaptation1.34690950
57MP0003091_abnormal_cell_migration1.34277792
58MP0009643_abnormal_urine_homeostasis1.30736309
59MP0000920_abnormal_myelination1.26446057
60MP0003186_abnormal_redox_activity1.25131445
61MP0001845_abnormal_inflammatory_respons1.23518622
62MP0010352_gastrointestinal_tract_polyps1.22513437
63MP0003705_abnormal_hypodermis_morpholog1.21120174
64MP0005167_abnormal_blood-brain_barrier1.17298026
65MP0010155_abnormal_intestine_physiology1.13829093
66MP0002998_abnormal_bone_remodeling1.13369335
67MP0000598_abnormal_liver_morphology1.12320907
68MP0003656_abnormal_erythrocyte_physiolo1.10571412
69MP0001819_abnormal_immune_cell1.06544139
70MP0009764_decreased_sensitivity_to1.06487132
71MP0005451_abnormal_body_composition1.06036876
72MP0002420_abnormal_adaptive_immunity1.05530436
73MP0002254_reproductive_system_inflammat1.04841092
74MP0002405_respiratory_system_inflammati1.03272033
75MP0005636_abnormal_mineral_homeostasis1.02225664
76MP0000604_amyloidosis1.01223170
77MP0010368_abnormal_lymphatic_system1.00095973
78MP0005503_abnormal_tendon_morphology1.00090911
79MP0005165_increased_susceptibility_to0.98737434
80MP0005171_absent_coat_pigmentation0.98272413
81MP0005164_abnormal_response_to0.97389962
82MP0002877_abnormal_melanocyte_morpholog0.96366464
83MP0009763_increased_sensitivity_to0.96046588
84MP0002876_abnormal_thyroid_physiology0.95170955
85* MP0005647_abnormal_sex_gland0.93534931
86MP0005310_abnormal_salivary_gland0.92375732
87MP0003448_altered_tumor_morphology0.88270805
88MP0008469_abnormal_protein_level0.87454567
89MP0005084_abnormal_gallbladder_morpholo0.87406425
90MP0009384_cardiac_valve_regurgitation0.87326684
91MP0000372_irregular_coat_pigmentation0.86528602
92MP0009278_abnormal_bone_marrow0.86230501
93MP0005670_abnormal_white_adipose0.85646245
94MP0009642_abnormal_blood_homeostasis0.84376150
95MP0003950_abnormal_plasma_membrane0.83935935
96MP0005220_abnormal_exocrine_pancreas0.83583108
97MP0005257_abnormal_intraocular_pressure0.83410360
98MP0001501_abnormal_sleep_pattern0.82267173
99MP0003279_aneurysm0.81332303
100MP0006036_abnormal_mitochondrial_physio0.80335248
101MP0005390_skeleton_phenotype0.80158731
102MP0005408_hypopigmentation0.78798610
103MP0005376_homeostasis/metabolism_phenot0.77737763
104MP0003690_abnormal_glial_cell0.77287608
105MP0005535_abnormal_body_temperature0.77119004
106MP0001851_eye_inflammation0.76920652
107MP0005197_abnormal_uvea_morphology0.76504969
108MP0000716_abnormal_immune_system0.76289714
109MP0003646_muscle_fatigue0.75937206
110MP0004381_abnormal_hair_follicle0.73647490
111MP0002078_abnormal_glucose_homeostasis0.72968031
112MP0009765_abnormal_xenobiotic_induced0.72671652
113MP0004130_abnormal_muscle_cell0.72036969
114MP0003045_fibrosis0.71971024
115MP0003329_amyloid_beta_deposits0.67332829
116MP0002933_joint_inflammation0.64006252
117MP0005266_abnormal_metabolism0.63116232
118MP0002971_abnormal_brown_adipose0.62968975
119MP0005334_abnormal_fat_pad0.62896290
120MP0002928_abnormal_bile_duct0.60276728
121MP0001756_abnormal_urination0.60222907
122MP0001661_extended_life_span0.59921232
123MP0006035_abnormal_mitochondrial_morpho0.59156508
124MP0000639_abnormal_adrenal_gland0.55721104
125MP0009379_abnormal_foot_pigmentation0.55493872
126MP0000579_abnormal_nail_morphology0.53276232
127MP0005166_decreased_susceptibility_to0.52774245
128MP0009053_abnormal_anal_canal0.52352177
129MP0002136_abnormal_kidney_physiology0.49508708
130MP0003075_altered_response_to0.48974652
131MP0005395_other_phenotype0.46157457
132MP0003638_abnormal_response/metabolism_0.44878672
133MP0005448_abnormal_energy_balance0.44582087
134MP0002796_impaired_skin_barrier0.44409747
135MP0004043_abnormal_pH_regulation0.43298318
136MP0003724_increased_susceptibility_to0.43115087
137MP0008874_decreased_physiological_sensi0.42067664
138MP0002822_catalepsy0.41828665
139MP0003718_maternal_effect0.41253676
140MP0005666_abnormal_adipose_tissue0.39962384
141MP0003953_abnormal_hormone_level0.39845627
142MP0000230_abnormal_systemic_arterial0.37399739
143MP0004782_abnormal_surfactant_physiolog0.37128856
144MP0002837_dystrophic_cardiac_calcinosis0.36671254
145MP0008873_increased_physiological_sensi0.35441437
146MP0005464_abnormal_platelet_physiology0.34059347
147MP0009672_abnormal_birth_weight0.33585968
148MP0001765_abnormal_ion_homeostasis0.33052383
149MP0005075_abnormal_melanosome_morpholog0.32448559
150MP0005058_abnormal_lysosome_morphology0.30828645
151MP0008872_abnormal_physiological_respon0.30311779
152MP0005595_abnormal_vascular_smooth0.30097338
153MP0002168_other_aberrant_phenotype0.29533578
154MP0005248_abnormal_Harderian_gland0.29050593
155MP0001853_heart_inflammation0.28960160
156MP0001881_abnormal_mammary_gland0.28597635
157MP0009115_abnormal_fat_cell0.26868129
158MP0004264_abnormal_extraembryonic_tissu0.24921139
159MP0000427_abnormal_hair_cycle0.24387387
160MP0002970_abnormal_white_adipose0.24307529
161MP0002060_abnormal_skin_morphology0.24267203
162MP0006082_CNS_inflammation0.24035719

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.19667649
2Deep venous thrombosis (HP:0002625)7.18962111
3* Intrahepatic cholestasis (HP:0001406)7.06790903
4Complement deficiency (HP:0004431)6.66287002
5Prolonged partial thromboplastin time (HP:0003645)6.51612820
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.45918496
7Xanthomatosis (HP:0000991)6.20864507
8Hypobetalipoproteinemia (HP:0003563)6.02033241
9Abnormality of liposaccharide metabolism (HP:0010968)5.33548190
10Abnormality of glycosphingolipid metabolism (HP:0004343)5.33548190
11Abnormality of glycolipid metabolism (HP:0010969)5.33548190
12Hyperlipoproteinemia (HP:0010980)5.24930171
13Abnormality of complement system (HP:0005339)4.83555190
14Hyperglycinemia (HP:0002154)4.71072952
15Joint hemorrhage (HP:0005261)4.66650475
16Hyperammonemia (HP:0001987)4.63290899
17Hypolipoproteinemia (HP:0010981)4.56437730
18Epidermoid cyst (HP:0200040)4.48671097
19Abnormality of the common coagulation pathway (HP:0010990)4.45176720
20Ketosis (HP:0001946)4.36611241
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.22925471
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.18676011
23Hyperglycinuria (HP:0003108)4.15764183
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.12765489
25Abnormality of glycine metabolism (HP:0010895)4.12270650
26Abnormality of serine family amino acid metabolism (HP:0010894)4.12270650
27Abnormality of aspartate family amino acid metabolism (HP:0010899)4.07831042
28Hypoalphalipoproteinemia (HP:0003233)4.00331952
29Abnormality of methionine metabolism (HP:0010901)3.99797826
30* Fat malabsorption (HP:0002630)3.95858227
31Abnormality of the intrinsic pathway (HP:0010989)3.88602436
32Optic neuritis (HP:0100653)3.83368865
33Retrobulbar optic neuritis (HP:0100654)3.83368865
34Conjugated hyperbilirubinemia (HP:0002908)3.74839394
35Orchitis (HP:0100796)3.71884105
36Hypoglycemic coma (HP:0001325)3.70438472
37Abnormality of pyrimidine metabolism (HP:0004353)3.63734932
38Loss of speech (HP:0002371)3.47818868
39Gastrointestinal stroma tumor (HP:0100723)3.40867012
40Abnormality of fatty-acid metabolism (HP:0004359)3.33625625
41Purpura (HP:0000979)3.32723611
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30143081
43Petechiae (HP:0000967)3.29507757
44Dysostosis multiplex (HP:0000943)3.28940766
45Ketoacidosis (HP:0001993)3.24417625
46Delayed CNS myelination (HP:0002188)3.23947946
47Hypercholesterolemia (HP:0003124)3.23525287
48Recurrent gram-negative bacterial infections (HP:0005420)3.22046281
49Systemic lupus erythematosus (HP:0002725)3.20010025
50Abnormality of serum amino acid levels (HP:0003112)3.18044513
51Hyperbilirubinemia (HP:0002904)3.16042062
52Keratoconjunctivitis sicca (HP:0001097)3.13347295
53Abnormality of nucleobase metabolism (HP:0010932)3.10441868
54Spontaneous abortion (HP:0005268)3.05525282
55Hypochromic microcytic anemia (HP:0004840)3.05132973
56Myocardial infarction (HP:0001658)3.01687075
57Gangrene (HP:0100758)2.98339431
58Hepatocellular carcinoma (HP:0001402)2.96404169
59Gout (HP:0001997)2.95833629
60Nephritis (HP:0000123)2.90911214
61Keratoconjunctivitis (HP:0001096)2.88972975
62Autoimmune thrombocytopenia (HP:0001973)2.88068747
63Vacuolated lymphocytes (HP:0001922)2.87466211
64Myositis (HP:0100614)2.87154352
65Abnormality of purine metabolism (HP:0004352)2.83795336
66Skin nodule (HP:0200036)2.81266897
67Metabolic acidosis (HP:0001942)2.79736467
68Recurrent bronchitis (HP:0002837)2.77612388
69Interstitial pulmonary disease (HP:0006530)2.75447862
70* Steatorrhea (HP:0002570)2.72271807
71Joint swelling (HP:0001386)2.71867998
72Lethargy (HP:0001254)2.66202888
73IgA deficiency (HP:0002720)2.65683323
74Vasculitis (HP:0002633)2.61115672
75Vascular calcification (HP:0004934)2.59392267
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58311691
77Dicarboxylic aciduria (HP:0003215)2.58311691
78Abnormality of macrophages (HP:0004311)2.56209287
79Abnormality of polysaccharide metabolism (HP:0011012)2.55515543
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55515543
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55515543
82Eczematoid dermatitis (HP:0000976)2.51477265
83Spastic diplegia (HP:0001264)2.49545220
84Parakeratosis (HP:0001036)2.49007548
85Sensorimotor neuropathy (HP:0007141)2.48335028
86Increased serum ferritin (HP:0003281)2.48309895
87Increased IgE level (HP:0003212)2.45213006
88Disinhibition (HP:0000734)2.43407160
89Autoimmune hemolytic anemia (HP:0001890)2.41932962
90Urinary glycosaminoglycan excretion (HP:0003541)2.40530449
91Mucopolysacchariduria (HP:0008155)2.40530449
92Mitral stenosis (HP:0001718)2.39899010
93Hypergammaglobulinemia (HP:0010702)2.39561125
94Mediastinal lymphadenopathy (HP:0100721)2.39424715
95Hypoglycemic seizures (HP:0002173)2.38861306
96Cerebral edema (HP:0002181)2.37920986
97Irritability (HP:0000737)2.37823836
98Acanthocytosis (HP:0001927)2.37774846
99Abnormal gallbladder morphology (HP:0012437)2.37150057
100Basal ganglia calcification (HP:0002135)2.34083734
101Vertebral compression fractures (HP:0002953)2.33504537
102Cholelithiasis (HP:0001081)2.33147619
103Increased IgM level (HP:0003496)2.32860812
104Cardiovascular calcification (HP:0011915)2.32155321
105Enlarged kidneys (HP:0000105)2.29526701
106Cholecystitis (HP:0001082)2.29154678
107Abnormal gallbladder physiology (HP:0012438)2.29154678
108Erythema (HP:0010783)2.27476016
109Emphysema (HP:0002097)2.27345692
110Malnutrition (HP:0004395)2.22312988
111Neurofibrillary tangles (HP:0002185)2.21997873
112Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.21557724
113Hematochezia (HP:0002573)2.20979251
114Pancreatitis (HP:0001733)2.19638904
115Amyloidosis (HP:0011034)2.16186961
116Thoracolumbar scoliosis (HP:0002944)2.15847188
117Glomerulonephritis (HP:0000099)2.15370235
118Generalized aminoaciduria (HP:0002909)2.14437755
119Hypoplasia of the iris (HP:0007676)2.13357697
120Vomiting (HP:0002013)2.12648711
121Pulmonary infiltrates (HP:0002113)2.11413864
122Osteolytic defects of the phalanges of the hand (HP:0009771)2.10905993
123Osteolytic defects of the hand bones (HP:0009699)2.10905993
124Recurrent sinusitis (HP:0011108)2.09964171
125Late onset (HP:0003584)2.08998957
126Opisthotonus (HP:0002179)2.08035029
127Rickets (HP:0002748)2.06551392
128Prolonged neonatal jaundice (HP:0006579)2.06279898
129Gingival bleeding (HP:0000225)2.05690601
130* Neonatal onset (HP:0003623)2.05653820
131Esophageal varix (HP:0002040)2.05616829
132Thrombophlebitis (HP:0004418)2.04519226
133Erythroderma (HP:0001019)2.03204851
134Recurrent bacterial skin infections (HP:0005406)2.02857405
135Increased cerebral lipofuscin (HP:0011813)2.02002680
136Brushfield spots (HP:0001088)2.01641337
137Abnormality of the gallbladder (HP:0005264)2.01429706
138Recurrent pneumonia (HP:0006532)1.97668792
139Status epilepticus (HP:0002133)1.97114208
140Abnormality of the vasculature of the conjunctiva (HP:0008054)1.94971810
141Arthralgia (HP:0002829)1.94885534
142Hyperinsulinemic hypoglycemia (HP:0000825)1.94106785
143Abnormality of the basal ganglia (HP:0002134)1.93675451
144Menorrhagia (HP:0000132)1.93395858
145Abnormality of the periventricular white matter (HP:0002518)1.92687297
146Alkalosis (HP:0001948)1.92094042
147Progressive neurologic deterioration (HP:0002344)1.90435839
148Abnormality of the pleura (HP:0002103)1.90305469
149Hemorrhage of the eye (HP:0011885)1.89872496
150Increased purine levels (HP:0004368)1.88743803
151Hyperuricemia (HP:0002149)1.88743803
152Abnormality of the pericardium (HP:0001697)1.87674425
153Spondylolisthesis (HP:0003302)1.87062837
154Pulmonary embolism (HP:0002204)1.85046117
155Onycholysis (HP:0001806)1.84852682
156Hypophosphatemic rickets (HP:0004912)1.84330924
157Dry hair (HP:0011359)1.83611111
158Abnormal cartilage morphology (HP:0002763)1.83590255
159Hydroxyprolinuria (HP:0003080)1.81960303
160Abnormality of proline metabolism (HP:0010907)1.81960303
161Recurrent lower respiratory tract infections (HP:0002783)1.81944386
162Confusion (HP:0001289)1.81934707
163Proximal tubulopathy (HP:0000114)1.81820831
164B lymphocytopenia (HP:0010976)1.81168390
165Stomatitis (HP:0010280)1.79888245
166Renal cortical cysts (HP:0000803)1.79716302
167Cellulitis (HP:0100658)1.78104490
168Abnormality of vitamin metabolism (HP:0100508)1.77709226
169Albinism (HP:0001022)1.76681306
170Arterial thrombosis (HP:0004420)1.76216501
171Abnormality of transition element cation homeostasis (HP:0011030)1.75302825
172Recurrent viral infections (HP:0004429)1.74153131
173Abnormality of B cell number (HP:0010975)1.73569980
174Abnormality of iron homeostasis (HP:0011031)1.73158677
175Back pain (HP:0003418)1.72185527
176Mutism (HP:0002300)1.72044333
177Polyneuropathy (HP:0001271)1.70354611
178Hemoptysis (HP:0002105)1.70023805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.06727452
2ERN14.83404199
3FGFR44.48978160
4SIK14.06611656
5ERBB43.97551750
6DDR23.81236253
7PIM23.36356721
8TAOK33.06952331
9INSRR3.04476742
10MATK2.62011302
11GRK72.40762949
12MAP2K42.39000552
13BMPR22.38261182
14MAPK112.25952347
15NME22.22663325
16KIT2.22455897
17IKBKB2.16354714
18MST1R1.99244715
19LATS11.88203621
20DAPK31.85528273
21MOS1.81215421
22TRIB31.78891815
23PIK3CG1.66389619
24PRPF4B1.64279822
25JAK31.59735555
26NEK11.54483110
27ABL21.50461742
28TYK21.46830827
29CHUK1.42590613
30PDGFRA1.41424897
31BLK1.38063072
32ADRBK21.37891948
33IRAK41.34152859
34NEK91.33837562
35MAP3K71.30974746
36PTK61.30932737
37DAPK21.29394572
38FLT31.26325980
39CDC42BPA1.26299019
40FRK1.26255394
41EPHA41.26061333
42FGFR21.25814621
43JAK21.23114334
44PINK11.22681614
45ERBB21.22210597
46PKN21.18730000
47PIM11.18293633
48TESK11.18169052
49MAPKAPK51.12106466
50GRK61.11694364
51MAP4K11.10912512
52STK38L1.10335101
53PRKAA21.07043952
54TAOK11.01426158
55MAPK150.99333545
56MAPK120.98651567
57JAK10.97761926
58MAPK40.95776215
59PRKCZ0.94701378
60KDR0.92031224
61TXK0.91675414
62CAMK2G0.91535769
63RIPK40.87981676
64ARAF0.85433118
65LYN0.85084021
66SYK0.84075896
67MAP3K140.83621380
68MET0.82638817
69TIE10.81445933
70EPHA30.81139970
71MAPK70.80390155
72SGK30.80230124
73IRAK30.78972688
74TBK10.78942508
75PBK0.77430545
76CDK60.76168638
77MAP3K100.76139661
78PKN10.75501018
79MAP2K30.74069478
80PRKACG0.72982325
81SGK20.72641493
82EPHB10.72118769
83PRKAA10.69632397
84CSNK1A1L0.65980094
85PRKCG0.65938706
86GSK3A0.65220810
87SCYL20.64396652
88MAP3K30.63376373
89CLK10.63082252
90SGK4940.60950391
91SGK2230.60950391
92MAP3K130.59888048
93PDPK10.57671971
94FGR0.56421823
95FGFR30.55988998
96CSNK1G20.55581939
97MAP2K60.55243374
98PTK20.54451188
99DYRK30.54214024
100VRK10.53438854
101EIF2AK30.53353803
102LATS20.50297360
103ABL10.50263890
104MAP3K110.49974338
105IGF1R0.49785206
106MARK30.49440274
107CDK90.48783705
108HIPK20.48534283
109MAP3K60.48079370
110PRKCQ0.47883548
111DYRK1B0.47451763
112GRK50.46978078
113RPS6KA50.46594273
114CSNK1G30.46310054
115INSR0.46086123
116CAMK1D0.45361629
117MAP2K10.45073306
118TGFBR10.44908300
119TAF10.44407360
120TAOK20.43605803
121PRKCD0.43526963
122EIF2AK20.42076397
123MAP3K50.40372987
124LCK0.40315874
125WNK30.40273211
126TGFBR20.39635726
127CSF1R0.39305014
128EGFR0.38201274
129STK240.38090357
130WNK40.37808059
131GRK10.37270420
132STK100.36715599
133CSK0.36443404
134DAPK10.36343034
135CSNK1G10.35809470
136PAK30.35665391
137PRKCH0.34924831
138RIPK10.34379372
139AKT30.34328147
140PRKCA0.33706400
141IRAK10.33544190
142RET0.32898907
143MAP3K10.32338527
144CAMK40.31030146
145PDK10.30324498
146PDGFRB0.30214518
147PDK30.29812245
148PDK40.29812245
149IKBKE0.29395568
150CDK40.29374115
151TRIM280.29089982
152MAPK30.28728472
153STK380.25247837
154CCNB10.24932651
155IRAK20.23949962
156MAPKAPK20.23490669
157FER0.23311860
158MTOR0.23300397
159MAP3K20.22902006
160ROCK20.22458324

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.67664166
2Nitrogen metabolism_Homo sapiens_hsa009103.53458631
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37300952
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.19606523
5Arginine biosynthesis_Homo sapiens_hsa002203.03496142
6Complement and coagulation cascades_Homo sapiens_hsa046102.89758499
7Asthma_Homo sapiens_hsa053102.83343844
8Tryptophan metabolism_Homo sapiens_hsa003802.76952377
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72473015
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58602706
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.56777082
12Fatty acid degradation_Homo sapiens_hsa000712.54276600
13Allograft rejection_Homo sapiens_hsa053302.52827328
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47332225
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47204031
16Butanoate metabolism_Homo sapiens_hsa006502.26510292
17Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23103888
18Peroxisome_Homo sapiens_hsa041462.19493598
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15516228
20NF-kappa B signaling pathway_Homo sapiens_hsa040642.10004823
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.01202956
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98130490
23Malaria_Homo sapiens_hsa051441.97755587
24Propanoate metabolism_Homo sapiens_hsa006401.97333994
25Autoimmune thyroid disease_Homo sapiens_hsa053201.90710687
26TNF signaling pathway_Homo sapiens_hsa046681.90463825
27Other glycan degradation_Homo sapiens_hsa005111.90147999
28PPAR signaling pathway_Homo sapiens_hsa033201.86445428
29Pertussis_Homo sapiens_hsa051331.83032965
30Fatty acid metabolism_Homo sapiens_hsa012121.82084218
31Histidine metabolism_Homo sapiens_hsa003401.81403095
32Chemical carcinogenesis_Homo sapiens_hsa052041.79152690
33Rheumatoid arthritis_Homo sapiens_hsa053231.79002723
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75883257
35* Steroid hormone biosynthesis_Homo sapiens_hsa001401.74749783
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73616899
37beta-Alanine metabolism_Homo sapiens_hsa004101.68021253
38Caffeine metabolism_Homo sapiens_hsa002321.67649488
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.66821305
40Graft-versus-host disease_Homo sapiens_hsa053321.66418545
41Retinol metabolism_Homo sapiens_hsa008301.65901316
42Staphylococcus aureus infection_Homo sapiens_hsa051501.64013057
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63954197
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63096218
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61544536
46Osteoclast differentiation_Homo sapiens_hsa043801.60073736
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57007408
48Leishmaniasis_Homo sapiens_hsa051401.55352589
49Bile secretion_Homo sapiens_hsa049761.54954898
50Phenylalanine metabolism_Homo sapiens_hsa003601.53750242
51Selenocompound metabolism_Homo sapiens_hsa004501.52611885
52Tyrosine metabolism_Homo sapiens_hsa003501.45940192
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43874896
54Lysosome_Homo sapiens_hsa041421.41667879
55Influenza A_Homo sapiens_hsa051641.40531511
56Pyruvate metabolism_Homo sapiens_hsa006201.38500383
57Sulfur metabolism_Homo sapiens_hsa009201.37418521
58Fatty acid elongation_Homo sapiens_hsa000621.30471846
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.30299700
60Starch and sucrose metabolism_Homo sapiens_hsa005001.27413929
61Vitamin B6 metabolism_Homo sapiens_hsa007501.23114701
62Folate biosynthesis_Homo sapiens_hsa007901.20608515
63Biosynthesis of amino acids_Homo sapiens_hsa012301.19212388
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19009683
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15219075
66ABC transporters_Homo sapiens_hsa020101.15008651
67Steroid biosynthesis_Homo sapiens_hsa001001.14963505
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13640733
69Herpes simplex infection_Homo sapiens_hsa051681.13468959
70Carbon metabolism_Homo sapiens_hsa012001.13218226
71Type I diabetes mellitus_Homo sapiens_hsa049401.11243802
72Tuberculosis_Homo sapiens_hsa051521.10715072
73Cyanoamino acid metabolism_Homo sapiens_hsa004601.06883447
74Measles_Homo sapiens_hsa051621.06282569
75Fat digestion and absorption_Homo sapiens_hsa049751.05769260
76Maturity onset diabetes of the young_Homo sapiens_hsa049501.04117899
77Jak-STAT signaling pathway_Homo sapiens_hsa046301.03881232
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03418660
79Toxoplasmosis_Homo sapiens_hsa051451.02175767
80Sphingolipid metabolism_Homo sapiens_hsa006001.01691459
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99351272
82Sulfur relay system_Homo sapiens_hsa041220.96050916
83Arginine and proline metabolism_Homo sapiens_hsa003300.94956039
84Viral myocarditis_Homo sapiens_hsa054160.94909248
85Primary immunodeficiency_Homo sapiens_hsa053400.93978903
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92694523
87Legionellosis_Homo sapiens_hsa051340.92322754
88Vitamin digestion and absorption_Homo sapiens_hsa049770.91079249
89Hematopoietic cell lineage_Homo sapiens_hsa046400.90284288
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87766605
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84750123
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82905416
93Lysine degradation_Homo sapiens_hsa003100.80631792
94Prion diseases_Homo sapiens_hsa050200.73780353
95Salmonella infection_Homo sapiens_hsa051320.73703484
96Hepatitis B_Homo sapiens_hsa051610.70344287
97One carbon pool by folate_Homo sapiens_hsa006700.70074521
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69580469
99Glycerolipid metabolism_Homo sapiens_hsa005610.67002471
100Glutathione metabolism_Homo sapiens_hsa004800.66571091
101B cell receptor signaling pathway_Homo sapiens_hsa046620.65745931
102Antigen processing and presentation_Homo sapiens_hsa046120.61547317
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61141932
104Fatty acid biosynthesis_Homo sapiens_hsa000610.58355165
105Pentose phosphate pathway_Homo sapiens_hsa000300.54962374
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52225080
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50187569
108Phagosome_Homo sapiens_hsa041450.48124323
109Metabolic pathways_Homo sapiens_hsa011000.47219363
110Apoptosis_Homo sapiens_hsa042100.46447702
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44326457
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38380825
113Prolactin signaling pathway_Homo sapiens_hsa049170.35667661
114Viral carcinogenesis_Homo sapiens_hsa052030.34277263
115Epstein-Barr virus infection_Homo sapiens_hsa051690.29207056
116Chemokine signaling pathway_Homo sapiens_hsa040620.29129770
117ECM-receptor interaction_Homo sapiens_hsa045120.28867529
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26384148
119Fructose and mannose metabolism_Homo sapiens_hsa000510.26168003
120Shigellosis_Homo sapiens_hsa051310.24365506
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23192412
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.22554255
123Insulin resistance_Homo sapiens_hsa049310.21742161
124Acute myeloid leukemia_Homo sapiens_hsa052210.21736644
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.21399167
126Galactose metabolism_Homo sapiens_hsa000520.21386764
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18563144
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.15326288
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13658615
130Linoleic acid metabolism_Homo sapiens_hsa005910.13016606
131Glucagon signaling pathway_Homo sapiens_hsa049220.11730432
132Mineral absorption_Homo sapiens_hsa04978-0.2180995
133Protein digestion and absorption_Homo sapiens_hsa04974-0.2162120
134Bladder cancer_Homo sapiens_hsa05219-0.1994340
135Renin-angiotensin system_Homo sapiens_hsa04614-0.1785857
136Hepatitis C_Homo sapiens_hsa05160-0.1658823
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1592417
138Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1590507
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1580782
140Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1580503
141Amoebiasis_Homo sapiens_hsa05146-0.1541820
142Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1442245
143African trypanosomiasis_Homo sapiens_hsa05143-0.1371052
144Insulin signaling pathway_Homo sapiens_hsa04910-0.1223870
145Regulation of autophagy_Homo sapiens_hsa04140-0.1163503
146Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1154579
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1150632
148Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1099630
149Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0877554
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0841924
151Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0608954
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0402653
153AMPK signaling pathway_Homo sapiens_hsa04152-0.0095855

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